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    Denture-Associated Oral Microbiome and Periodontal Disease Causing an Anaerobic Pyogenic Liver Abscess in an Immunocompetent Patient: A Case report and Review of the Literature.
    Gastroenterology Res 2018 Jun 31;11(3):241-246. Epub 2018 May 31.
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Saint Louis University School of Medicine, St Louis, MO, USA.
    Pyogenic liver abscesses (PLA) develop from the spread of infection through the portal circulation, biliary infections or arterial hematogenous seeding in the setting of systemic infections. PLA are often poly-microbial and are uncommonly reported to be due to anaerobic species. We report the case of a previously healthy, immunocompetent 63-year-old man with hepatic abscesses as a result of periodontal disease. Read More

    In Vitro Antifungal Susceptibility of Species Isolated from Iranian Patients with Denture Stomatitis.
    Biomed Res Int 2018 16;2018:3086586. Epub 2018 May 16.
    Department of Medical Mycology and Parasitology, School of Medicine, Babol University of Medical Sciences, Babol, Iran.
    Background: -associated denture stomatitis (CADS) is a common fungal infection in people who wear dentures. The main objective of this study was to make molecular identification of causative agents of CADS and in vitro antifungal susceptibility testing (AFST) in the Iranian patients with denture stomatitis.

    Methods: A total of 134 spp. Read More

    Chair-Side Direct Microscopy Procedure for Diagnosis of Oral Candidiasis in an Adolescent.
    Case Rep Dent 2018 29;2018:6561735. Epub 2018 Apr 29.
    Department of Pediatric Dentistry, Toulouse Dental School, University of Toulouse III, Toulouse University Hospital, Toulouse, France.
    Oral candidiasis is caused by fungi of the genus and one of the most common opportunistic fungal infections of the human oral cavity. Given the clinical variability of this disease, microbiological techniques are often required for clinical confirmation, as well as establishing a differential diagnosis with other diseases. The aim of this brief technical report is to illustrate a simple chair-side method, which can provide immediate microscopic diagnosis of this disease. Read More

    Role of laser or photodynamic therapy in treatment of denture stomatitis: A systematic review.
    J Prosthet Dent 2018 May 25. Epub 2018 May 25.
    Associate Professor, Dental Implants Research Center and Department of Prosthodontics, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.
    Statement Of Problem: Denture stomatitis (DS) is an inflammatory oral lesion that occurs mostly in elderly denture wearers and that can negatively affect their quality of life. The conventional treatment plan for DS is topical or systemic fungicidal drug therapy, which are not without side effects.

    Purpose: The purpose of this systematic review was to evaluate the clinical outcomes of using low-level laser therapy (LLLT) or photodynamic therapy (PDT) in the treatment of DS by reviewing high-quality published articles. Read More

    The severity of denture stomatitis as related to risk factors and different Candida spp.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Mar 22. Epub 2018 Mar 22.
    National Reference Medical Mycology Laboratory, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Serbia. Electronic address:
    Objectives: 1) To select patients with Candida-related denture stomatitis (DS) and to study possible risk factors associated with DS, 2) to evaluate the severity of DS according to Newton's classification, and 3) to investigate the association between the presence of non-albicans Candida spp. (NAC) or mixed Candida spp. and the severity of DS. Read More

    Mechanical and Physicochemical Properties of Newly Formed ZnO-PMMA Nanocomposites for Denture Bases.
    Nanomaterials (Basel) 2018 May 6;8(5). Epub 2018 May 6.
    Department of Prosthodontics, Medical University of Warsaw, 02-006 Warsaw, Poland.
    Aim: The aim of this study was to investigate the selected properties of zinc oxide- polymethyl methacrylate (ZnO-PMMA) nanocomposites that can influence the microorganism deposition on their surface.

    Materials And Methods: Non-commercial ZnO-NPs were prepared, characterized and used for the preparation of PMMA nanocomposite. Roughness, absorbability, contact angle and hardness of this new nanomaterial were evaluated. Read More

    Photodynamic inactivation of Candida ssp. on denture stomatitis. A clinical trial involving palatal mucosa and prosthesis disinfection.
    Photodiagnosis Photodyn Ther 2018 Jun 17;22:212-216. Epub 2018 Apr 17.
    Centro de Lasers e Aplicações, Instituto de Pesquisas Energéticas e Nucleares, IPEN-CNEN/SP, São Paulo, Brazil. Electronic address:
    Denture stomatitis (DS) is the most common oral fungal infection in denture wearers. Photodynamic inactivation (PDI) has been showing to be an effective technique in vivo against fungi, including fungal infections in the oral cavity. The disinfection of both oral mucosa and denture may represent a real advantage in terms of fungus control. Read More

    Photodynamic inactivation in the expression of the Candida albicans genes ALS3, HWP1, BCR1, TEC1, CPH1, and EFG1 in biofilms.
    Lasers Med Sci 2018 Mar 27. Epub 2018 Mar 27.
    Department of Biosciences and Oral Diagnosis, São Paulo State University (Unesp), Institute of Science and Technology, Campus of São José dos Campos, Engenheiro Francisco José Longo Avenue, 777, Jardim São Dimas, São José dos Campos, São Paulo, CEP 12245-000, Brazil.
    The objective of this study was to evaluate the effects of photodynamic inactivation (PDI) on Candida albicans biofilms, evaluating its effects on gene expression of ALS3, HWP1, BCR1, TEC1, CPH1, and EFG1 by yeast. Three samples of C. albicans were used in this study: a clinical sample from a patient with HIV (39S), a clinical sample from a patient with denture stomatitis lesion (Ca30), and a standard strain ATCC 18804. Read More

    New paste for severe stomatitis in patients undergoing head-and-neck cancer radiotherapy and/or chemotherapy with oral appliance.
    BMC Cancer 2018 03 2;18(1):245. Epub 2018 Mar 2.
    Department of Dentistry and Oral Surgery, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo, 663-8501, Japan.
    Background: The aim of the present study was to evaluate the physical properties of "admixture paste", which is a commercially available gel containing hinokitiol for use against severe stomatitis, and its characteristics as a moisturizing gel and denture adhesive.

    Methods: The admixture paste, which contained dexamethasone (Dexaltin®), gel for oral care (Refrecare H®) and petrolatum, and its 3 components, either alone or in different combinations, were subjected to viscosity, adhesiveness and elution testing to compare their physical properties. Viscosity was measured with a stress-controlled rheometer. Read More

    Management of denture stomatitis: a narrative review.
    J Biol Regul Homeost Agents 2018 Jan-Feb;32(2 Suppl. 1):113-116
    Multidisciplinary Department of Medical-Surgical and Dental Specialties, University of Campania Luigi Vanvitelli, Naples, Italy.
    Candida albicans is a typical commensal microorganism of the oral cavity that can become virulent in certain conditions and cause denture stomatitis (DS). Many conditions can predispose for DS, including local and systemic alterations. The therapeutical approach to DS is various and both topical and systemic alternatives can be considered. Read More

    Denture-associated biofilm infection in three-dimensional oral mucosal tissue models.
    J Med Microbiol 2018 Mar 11;67(3):364-375. Epub 2018 Jan 11.
    1​Oral and Biomedical Sciences, School of Dentistry, Cardiff University, Cardiff, UK.
    Purpose: In vitro analyses of virulence, pathogenicity and associated host cell responses are important components in the study of biofilm infections. The Candida-related infection, denture-associated oral candidosis, affects up to 60 % of denture wearers and manifests as inflammation of palatal tissues contacting the denture-fitting surface. Commercially available three-dimensional tissue models can be used to study infection, but their use is limited for many academic research institutions, primarily because of the substantial purchase costs. Read More

    Cytokine gene polymorphism in denture stomatitis patients: A clinical study.
    Oral Dis 2018 Feb 9. Epub 2018 Feb 9.
    Department of Prosthodontics, Faculty of Health, School of Dentistry, Witten/Herdecke University, Witten, Germany.
    Objective: This clinical study investigated the association between cytokine gene polymorphism and Candida growth in denture stomatitis (DS) patients.

    Subjects And Methods: Saliva and blood samples of 160 complete denture wearers (80 healthy controls and 80 with DS) were collected for mycological and gene polymorphism testing, respectively. Salivary Candida growth and TNF-α, TGF-β, IL-6, and IL-10 genotypes were investigated. Read More

    Effect of incorporation of surface pre-reacted glass ionomer filler in tissue conditioner on the inhibition of Candida albicans adhesion.
    Dent Mater J 2018 Jun 8;37(3):453-459. Epub 2018 Feb 8.
    Removable Partial Prosthodontics, Tokyo Medical and Dental University (TMDU).
    We investigated the effects of incorporation of surface pre-reacted glass ionomer (S-PRG) filler in tissue conditioner (TC) on Candida albicans adhesion. We prepared specimens containing 0, 5, 10, or 20 wt% of S-PRG filler, and measured the amount of C. albicans on the surface using a colony forming unit (CFU) assay and scanning electron microscopic images. Read More

    Evaluation of biofilm formation on various parts of implant material surfaces.
    Niger J Clin Pract 2018 Jan;21(1):33-37
    Department of Periodontology, Faculty of Dentistry, Ordu University, Ordu, Turkey.
    Aims: Candida albicans adhesion to any oral substrata is the first and essential stage in forming a pathogenic fungal biofilm. In general, yeast cells have remarkable potential to adhere to host surfaces, such as teeth or mucosa, and to artificial, non-biological surfaces, such as dental materials. C. Read More

    Evaluation of anti-enzyme properties of Origanum vulgare essential oil against oral Candida albicans.
    J Mycol Med 2018 Mar;28(1):94-100
    Department of restorative dentistry, school of dentistry, Federal university of Pelotas, 457, street Gonçalves Chaves, Downtown, 96015-560 Pelotas - RS, Brazil. Electronic address:
    This study aimed to evaluate the anti-enzymatic activity of Origanum vulgare (oregano) essential oil against 15 strains of Candida albicans. Candida albicans samples were isolated from the oral mucosa of patients with denture stomatitis treated in a Dentistry school on a public university. Preparation of the inoculum was performed with a suspension of C. Read More

    Superhydrophilic co-polymer coatings on denture surfaces reduce Candida albicans adhesion-An in vitro study.
    Arch Oral Biol 2018 Mar 27;87:143-150. Epub 2017 Dec 27.
    Department of Removable Partial Prosthodontics, Graduate School, Tokyo Medical and Dental University (TMDU), 1-5-45, Yushima, Bunkyo-ku, Tokyo, 113-8549, Japan. Electronic address:
    Objective: In this study, we aimed to investigate denture-base-resin coatings prepared with a crosslinkable co-polymer containing sulfobetaine methacrylamide (SBMAm) and the relationship between their surface characteristics and the initial adhesion of Candida albicans (C. albicans).

    Methods: Acrylic resin discs were coated with co-polymers containing various concentrations of SBMAm and N,N'-(4,7,10-trioxa-1,13-tridecadiamine) diacrylamide (JDA) as crosslinking agent. Read More

    Denture Stomatitis: Causes, Cures and Prevention.
    Prim Dent J 2017 Dec;6(4):46-51
    Removable dentures are worn by 20% of the UK population and two thirds of these individuals have denture stomatitis. Poor oral hygiene is commonplace among this group, as is smoking and xerostomia, which also contribute to the development of denture stomatitis. A complex polymicrobial biofilm is able to proliferate on the surface of denture materials and matures to form visible denture plaque. Read More

    Antimicrobial activity of denture adhesive associated with Equisetum giganteum- and Punica granatum-enriched fractions against Candida albicans biofilms on acrylic resin surfaces.
    Biofouling 2018 01 18;34(1):62-73. Epub 2017 Dec 18.
    a Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry , University of São Paulo , Bauru , Brazil.
    Candida biofilms adhere to the internal surface of removable dentures, which is an etiological factor in the pathogenesis of denture stomatitis (DS). Adhesive materials are used at the base of maxillary complete dentures to improve their retention and chewing qualities. This article reports the antimicrobial activity of the enriched fractions of Equisetum giganteum and Punica granatum incorporated into a denture adhesive against C. Read More

    Antimicrobial Photodynamic Therapy mediated by Photodithazine in the treatment of denture stomatitis: A case report.
    Photodiagnosis Photodyn Ther 2018 Mar 2;21:168-171. Epub 2017 Dec 2.
    Department of Dental Materials and Prosthodontics, São Paulo State University (Unesp), School of Dentistry, Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil. Electronic address:
    Antimicrobial Photodynamic Therapy (aPDT) mediated by Photodithazine (PDZ) has shown efficacy in the inactivation of Candida spp. in in vitro and in vivo studies. This preliminary study reports five clinical cases of patients with denture stomatitis (DS) treated with PDZ-mediated aPDT. Read More

    Adherence of to complete denture surfaces : A comparison of conventional and CAD/CAM complete dentures.
    J Adv Prosthodont 2017 Oct 16;9(5):402-408. Epub 2017 Oct 16.
    Department of Pathology, School of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Purpose: The goal of this study was to compare the adhesion of to the surfaces of CAD/CAM and conventionally fabricated complete denture bases.

    Materials And Methods: Twenty discs of acrylic resin poly (methyl methacrylate) were fabricated with CAD/CAM and conventional procedures (heat-polymerized acrylic resin). The specimens were divided into two groups: 10 discs were fabricated using the CAD/CAM procedure (Wieland Digital Denture Ivoclar Vivadent), and 10 discs were fabricated using a conventional flasking and pressure-pack technique. Read More

    Effect of Incorporation of Antifungal Agents on the Ultimate Tensile Strength of Temporary Soft Denture Liners.
    J Prosthodont 2018 Feb 14;27(2):177-181. Epub 2017 Nov 14.
    Department of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil.
    Purpose: To investigate the ultimate tensile strength of temporary soft denture liners modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm (SC5314) determined in previous microbiological research.

    Materials And Methods: Dumbbell-shaped specimens (n = 7) with a central cross-sectional area of 6 × 3 × 33 mm were produced by Softone and Trusoft, without (control) or with incorporation of drugs in powder form at MICs for C. albicans biofilm (per g of material powder): nystatin (0. Read More

    Hygiene practices in removable prosthodontics: A systematic review.
    Int J Dent Hyg 2018 May 9;16(2):179-201. Epub 2017 Nov 9.
    Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
    Objective: To systematically review the recent scientific evidence about the hygiene practices of removable prostheses relative to the effectiveness, colour and dimensional stability. This review aimed also to identify patients' attitudes and habits towards denture hygiene.

    Methods: Three electronic databases (MEDLINE/PubMed, Scopus and Cochrane Library) were screened, in English language, between January 1995 and December 2016. Read More

    Surface Roughness Changes in Denture Liners in Denture Stomatitis Patients.
    Int J Prosthodont 2017 November/December;30(6):561–564. Epub 2017 Oct 30.
    Purpose: This randomized clinical trial assessed how surface roughness (Ra) in resilient liners was affected by soft tissue health conditions and time-related aspects in patients with complete dentures.

    Methods: Specimens of acrylic resin (control) and denture liners (silicone-based or acrylic resin-based) were inserted into the dentures of patients with and without denture stomatitis (n = 30). Ra was evaluated before denture insertion and after 7, 14, and 21 days of prosthesis wearing. Read More

    Isolation of Candida spp. from denture-related stomatitis in Pará, Brazil.
    Braz J Microbiol 2018 Jan - Mar;49(1):148-151. Epub 2017 Jul 29.
    Evandro Chagas Institute, Bacteriology and Mycology Section, Mycology Laboratory, Belém, PA, Brazil.
    The aim of this study was to isolate and identify Candida species from the oral cavity of denture wearers with denture-related stomatitis who were attended at the University Federal of Pará (Belém City, Pará State, Brazil). A total of 36 denture wearers with denture-related stomatitis were included, and type I (50%), type II (33%) and type III (17%) stomatitis were observed. Candida spp. Read More

    Effect of Mixed with Tissue Conditioners in Varying Doses on Colonization and Inhibition of : An Study.
    Contemp Clin Dent 2017 Jul-Sep;8(3):446-450
    Department of Prosthodontics and Crown and Bridge, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
    Aims And Objectives: The study was conducted to evaluate the Colonization & Inhibition of Candida albicans in selected commercially available denture lining materials material by mixing them with varying concentrations and doses of tea tree oil.

    Materials And Methods: Five test discs of 10mm diameter and 1.5mm thickness were prepared using commercially available soft denture lining materials (Viscogel and GC-soft). Read More

    Antibiofilm Activity and Mechanism of Action of the Disinfectant Chloramine T on Candida spp., and Its Toxicity against Human Cells.
    Molecules 2017 Sep 17;22(9). Epub 2017 Sep 17.
    Graduate Program in Dentistry, School of Dentistry, Universidade Federal da Paraíba (UFPB), João Pessoa PB 58051900, Brazil.
    We evaluated the antifungal and anti-biofilm activity, mechanism of action and cytotoxicity of chloramine T trihydrate (CAT) against spp. The Minimum Inhibitory and Fungicidal Concentrations (MIC/MFC) of CAT were determined. Changes in CAT-treated growth kinetics and micromorphology were evaluated, as well as the mechanism of action, and its effects on biofilm. Read More

    Contact stomatitis.
    Clin Dermatol 2017 Sep - Oct;35(5):435-440. Epub 2017 Jun 24.
    Department of Dermatology, Mayo Clinic, Scottsdale, AZ.
    Contact stomatitis occurs in up to 10% of the population. Mechanical or chemical irritation, ill-fitting dentures, and dental fillings can induce irritant contact stomatitis. Type I hypersensitivity and type IV hypersensitivity to dental products and foods are frequently responsible for the allergic types of contact stomatitis. Read More

    In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans.
    J Oral Sci 2017 ;59(3):425-430
    Department of of Oral Medicine, Faculty of Dentistry, Rafsanjan University of Medical Sciences.
    This study investigated the antifungal effects of low-molecular-weight chitosan solution on Candida albicans in denture stomatitis in comparison with nystatin suspension. This randomized, sing-leblind clinical trial included 40 patients diagnosed with denture stomatitis. Patients were divided into two groups, wherein one was treated with chitosan and the other with nystatin for 2 weeks. Read More

    Antifungal and Mechanical Properties of Tissue Conditioner Containing Plant-Derived Component: An In Vitro Study.
    J Prosthodont 2017 Sep 13. Epub 2017 Sep 13.
    Department of Oral and Maxillofacial Prosthodontics and Oral Implantology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
    Purpose: To evaluate the antifungal activity and mechanical properties of a novel antifungal tissue conditioner containing Juncus powder.

    Materials And Methods: Juncus powder was mixed with GC tissue conditioner at concentrations of 2.5%, 5. Read More

    Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis.
    J Prosthodont 2017 Sep 5. Epub 2017 Sep 5.
    National Reference Medical Mycology Laboratory, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Serbia.
    Purpose: Denture stomatitis (DS) is a disease characterized by inflammation and erythema of the oral mucosa areas covered by the denture. Multifactorial etiological factors contribute to DS, but it seems that Candida plays the key role. The aim of the study was to evaluate the denture sonication method to: (i) increase the possibility of diagnosing patients with Candida-associated DS; (ii) detect and identify the mixed Candida spp. Read More

    Inhibitory effect of zirconium oxide nanoparticles on adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention.
    Int J Nanomedicine 2017 28;12:5409-5419. Epub 2017 Jul 28.
    Department of Biomedical Dental Sciences, College of Dentistry, University of Dammam, Dammam, Saudi Arabia.
    Background: Despite drawbacks, cold-cured acrylic resin is still the most common material used in denture repair. Zirconia nanoparticles were among the reinforcements added to increase the strength of the resin. The effect on due to the addition of zirconia nanoparticles to the resin has not been investigated. Read More

    Heat-Polymerized Resin Containing Dimethylaminododecyl Methacrylate Inhibits Candida albicans Biofilm.
    Materials (Basel) 2017 Apr 20;10(4). Epub 2017 Apr 20.
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
    The prevalence of stomatitis, especially caused by , has highlighted the need of new antifungal denture materials. This study aimed to develop an antifungal heat-curing resin containing quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM), and evaluate its physical performance and antifungal properties. The discs were prepared by incorporating DMADDM into the polymer liquid of a methyl methacrylate-based, heat-polymerizing resin at 0% (control), 5%, 10%, and 20% (/). Read More

    In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention.
    Int J Environ Res Public Health 2017 07 8;14(7). Epub 2017 Jul 8.
    Department of Prosthetic Dental Sciences, College of Dentistry, Kind Saud University, Riyadh 11692, Saudi Arabia.
    adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against . Eighty acrylic resin specimens were fabricated and divided into eight groups ( = 10) according to thymoquinone concentrations of 0. Read More

    The effect of enriching denture adhesives with chlorhexidine diacetate on the proliferation of Candida albicans: an in vitro analysis.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):45-52
    Senior Lecturer, Dept. of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
    Denture adhesives are widely used in dentistry. The growth of Candida albicans on the denture base is common on both jaws, particularly in elderly patients. A strong correlation has been found between the growth of Candida albicans and dentures, potentially leading to denture stomatitis. Read More

    Recent advances in tissue conditioners for prosthetic treatment: A review.
    Adv Clin Exp Med 2017 Jul;26(4):723-728
    Department of Prosthetic Dentistry, University of Medical Sciences, Poznań, Poland.
    Tissue conditioners (TCs) are short-term soft liners, formed in situ from a mixture of a polymer powder and a liquid plasticizer. This article reviews the recent advances in the composition, functions, clinical use, gelation process, and physical properties of TCs and their effects on denture bases and oral mucosa. TCs are used to improve the fit and function of an ill-fitting denture. Read More

    Oral Candida carriage and species prevalence in denture stomatitis patients with and without diabetes.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2):343-346
    Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe, University of Frankfurt, Frankfurt, Germany.
    The objective of this study was to assess the oral Candida carriage and species prevalence in denture stomatitis (DS) patients with and without diabetes mellitus (DM). To address the focused question “In patients receiving dentures, how does having diabetes compared to no diabetes influences the carriage and species prevalence of oral Candida?” Indexed databases were explored without time or language restrictions up to and including February 2017. Nine studies were included. Read More

    The effect of nanochitosans particles on biofilm formation.
    Curr Med Mycol 2016 Jun;2(2):28-33
    Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Background And Purpose: In people wearing dentures, the growth of various species under the prosthesis leads to the formation of biofilm, which can play the role of a reservoir for and other kinds of microbes. Since nano-chitosan particles can cause lasting antimicrobial activity, a more recent approach that utilizes acrylic resins with nano-chitosan particles is proposed. Therefore, we aimed to study the inhibitory effect of nano-chitosan particles on the biofilm formation of species in acrylic resins. Read More

    Phagocytosis and nitric oxide production by peritoneal adherent cells in response to Candida albicans in aging: a collaboration to elucidate the pathogenesis of denture stomatitis.
    J Appl Oral Sci 2017 May-Jun;25(3):265-273
    Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Cirurgia, Estomatologia, Patologia e Radiologia. Bauru, SP, Brasil.
    Objective: The aim of this study was to investigate the influence of aging on the internalization and the production of nitric oxide (NO) by peritoneal adherent cells (PAC), in response to Candida albicans (C. albicans).

    Material And Methods: PAC obtained from young and aged mice were challenged with dead or viable C. Read More

    The Effect of Treatment of Denture-related Stomatitis on Peripheral T Cells and Monocytes.
    Oral Health Prev Dent 2017;15(3):259-268
    Purpose: Systemic immune activation has been recently linked to chronic inflammatory disorders of the oral cavity, particularly to periodontitis. The purpose of this study was to determine whether treatment of a fungus-induced oral inflammation, namely denture-related stomatitis (DRS), can affect the activation of the systemic immune response.

    Materials And Methods: Peripheral blood from patients with denture-related stomatitis caused by Candida albicans infection (n = 15) was collected at three time points: before treatment with nystatin, at the end of therapy and 2 months after finishing therapy. Read More

    Efficacy of Neem Extract and Three Antimicrobial Agents Incorporated into Tissue Conditioner in Inhibiting the Growth of and .
    J Clin Diagn Res 2017 May 1;11(5):ZC97-ZC101. Epub 2017 May 1.
    Dean and Professor and Head, Department of Conservative Dentistry, New Horizon Dental College and Research Centre, Bilaspur, Chhattisgarh, India.
    Introduction: Denture stomatitis is an inflammatory condition which compromises the mucosal surface beneath dentures. The aetiology of denture stomatitis is usually multifactorial which varies from trauma from ill fitting denture to poor immune system. There are evidences that denture stomatitis is an outcome of multispecies biofilms that include and . Read More

    Photodvnamic Therapy in Endodontics.
    J Contemp Dent Pract 2017 Jun 1;18(6):534-538. Epub 2017 Jun 1.
    Department of Conservative Dentistry, Showa University Dental Hospital, Tokyo, Japan.
    Commonly used irrigants do not always eradicate the entire microbial flora in infected root canals. Therefore, several other strategies, such as photodynamic therapy (PDT) have been developed. Photoactivated disinfection is based on the interaction of a photosensitive antibacterial agent and a light source. Read More

    Nicotine Upregulates Coaggregation of Candida albicans and Streptococcus mutans.
    J Prosthodont 2017 Jun 9. Epub 2017 Jun 9.
    Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, IN.
    Purpose: Denture stomatitis is a condition of painless inflammation of denture-bearing mucosa. Reports indicate that nicotine, the major psychoactive ingredient in tobacco, increases growth of Streptococcus mutans and Candida albicans in denture biofilm. The purpose of this study was to determine the in vitro effects of nicotine on coaggregation of C. Read More

    The essential oil of Allium sativum as an alternative agent against Candida isolated from dental prostheses.
    Rev Iberoam Micol 2017 Jul - Sep;34(3):158-164. Epub 2017 Jun 1.
    Facultad de Estomatología Universidad Autónoma de San Luis Potosí, Mexico. Electronic address:
    Background: The colonization of the surfaces of dental prostheses by Candida albicans is associated with the development of denture stomatitis. In this context, the use of fluconazole has been proposed, but its disadvantage is microbial resistance. Meanwhile, the oil of Allium sativum has shown an effect in controlling biofilm formation by C. Read More

    Fabrication of denture base materials with antimicrobial properties.
    J Prosthet Dent 2018 Feb 26;119(2):292-298. Epub 2017 May 26.
    Associate Professor, Faculty of Chemical Engineering, Biotechnology Research Center, Sahand University of Technology, Tabriz, Iran.
    Statement Of Problem: Acrylic resin denture base resins are colonized by oral and nonoral bacteria and Candida species. This reservoir of microorganism causes denture stomatitis, which can be implicated in some life-threating infections in older denture wearers.

    Purpose: The purpose of this in vitro study was to incorporate quaternized N,N-dimethylaminoethyl methacrylate (DMAEMA) monomer into a denture base resin and investigate its antimicrobial and mechanical properties. Read More

    Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients.
    PLoS One 2017 11;12(5):e0176755. Epub 2017 May 11.
    Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago, Chile.
    Candida albicans biofilms play a key role in denture stomatitis, one of the most common oral pathologies in elderly people. Because biofilms are highly resistant to antifungals, new pharmacological strategies are needed. Aspirin and nitric oxide-donor molecules have both shown antibiofilm effects on C. Read More

    Prevalence of Chronic Erythematous Candidiasis in Lebanese Denture Wearers: a Clinico-microbiological Study.
    Mater Sociomed 2017 Mar;29(1):26-29
    Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon.
    Objective: Chronic erythematous candidiasis also known as denture-related stomatitis refers to inflammatory changes of the denture-bearing mucosa. The aim of this study was to evaluate the prevalence of chronic erythematous candidiasis in a Lebanese population using clinical and microbiological examinations.

    Materials And Methods: Ninety-eight patients wearing full acrylic maxillary denture (50 women and 48 men) were included in this study. Read More

    The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin.
    Sci Rep 2017 May 8;7(1):1547. Epub 2017 May 8.
    Department of Stomatology, Kunming General Hospital of Chengdu Military Command, Teaching Hospital of Kunming Medical University, Kunming, Yunnan, China.
    Poly-methyl methacrylate (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the prevention of denture stomatitis. This study evaluated the antifungal effects on Candida albicans ATCC90028, the cytotoxicity toward human dental pulp cells (HDPCs), and the mechanical properties of a silver bromide/cationic polymer nano-composite (AgBr/NPVP)-modified PMMA-based dental resin. AgBr/NPVP was added to the PMMA resin at 0. Read More

    Improving practice guidelines for the treatment of denture-related erythematous stomatitis: a study protocol for a randomized controlled trial.
    Trials 2017 May 5;18(1):211. Epub 2017 May 5.
    Faculty of Dental Medicine, Université de Montréal, Montreal, QC, Canada.
    Background: Denture-related erythematous stomatitis (DES) is a chronic biofilm-mediated disease, affecting one in every three complete denture wearers. Antifungals are the treatment most commonly prescribed by oral health professionals, based on the belief that colonization by Candida spp. is the main cause of DES. Read More

    Early Adhesion of Candida albicans onto Dental Acrylic Surfaces.
    J Dent Res 2017 Jul 1;96(8):917-923. Epub 2017 May 1.
    1 Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.
    Denture-associated stomatitis is a common candidal infection that may give rise to painful oral symptoms, as well as be a reservoir for infection at other sites of the body. As poly (methyl methacrylate) (PMMA) remains the main material employed in the fabrication of dentures, the aim of this research was to evaluate the adhesion of Candida albicans cells onto PMMA surfaces by employing an atomic force microscopy (AFM) single-cell force spectroscopy (SCFS) technique. For experiments, tipless AFM cantilevers were functionalized with PMMA microspheres and probed against C. Read More

    Equisetum giganteum influences the ability of Candida albicans in forming biofilms over the denture acrylic resin surface.
    Pharm Biol 2017 Dec;55(1):1698-1702
    c Department of Prosthodontics , Bauru School of Dentistry, University of São Paulo (USP) , Bauru , SP , Brazil.
    Context: Equisetum giganteum L. (Equisetaceae) is an endemic plant of Central and South America used in traditional medicine. Natural drugs have been frequently used in the treatment of a myriad of diseases, proving to be an alternative to synthetic chemicals, and have been intensively studied in the prevention of sicknesses, including oral diseases. Read More

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