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    Denture Stomatitis – A Clinical Update.
    Dent Update 2016 Jul-Aug;43(6):529-30, 533-5
    Denture stomatitis is a benign condition, usually asymptomatic, that can affect edentulous patients. Studies have reported a prevalence of denture stomatitis affecting over 75% of denture wearers and, whilst the aetiology may be multifactorial, Candida albicans has a strong association with the condition, along with denture trauma and poor denture hygiene being associated local risk factors. This paper describes the aetiology, diagnosis and treatment of denture stomatitis, with the aim of helping clinicians to provide appropriate management of this condition. Read More

    Adherence of Candida to complete denture surfaces in vitro: A comparison of conventional and CAD/CAM complete dentures.
    J Adv Prosthodont 2017 Oct 16;9(5):402-408. Epub 2017 Oct 16.
    Department of Pathology, School of Medicine, King Saud University, Riyadh, Saudi Arabia.
    Purpose: The goal of this study was to compare the adhesion of Candida albicans to the surfaces of CAD/CAM and conventionally fabricated complete denture bases.

    Materials And Methods: Twenty discs of acrylic resin poly (methyl methacrylate) were fabricated with CAD/CAM and conventional procedures (heat-polymerized acrylic resin). The specimens were divided into two groups: 10 discs were fabricated using the CAD/CAM procedure (Wieland Digital Denture Ivoclar Vivadent), and 10 discs were fabricated using a conventional flasking and pressure-pack technique. Read More

    Effect of Incorporation of Antifungal Agents on the Ultimate Tensile Strength of Temporary Soft Denture Liners.
    J Prosthodont 2017 Nov 14. Epub 2017 Nov 14.
    Department of Dentistry, State University of Ponta Grossa, Ponta Grossa, Brazil.
    Purpose: To investigate the ultimate tensile strength of temporary soft denture liners modified by minimum inhibitory concentrations (MICs) of antifungal agents for Candida albicans biofilm (SC5314) determined in previous microbiological research.

    Materials And Methods: Dumbbell-shaped specimens (n = 7) with a central cross-sectional area of 6 × 3 × 33 mm were produced by Softone and Trusoft, without (control) or with incorporation of drugs in powder form at MICs for C. albicans biofilm (per g of material powder): nystatin (0. Read More

    Hygiene practices in removable prosthodontics: A systematic review.
    Int J Dent Hyg 2017 Nov 9. Epub 2017 Nov 9.
    Department of Prosthodontics, School of Dentistry, Faculty of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece.
    Objective: To systematically review the recent scientific evidence about the hygiene practices of removable prostheses relative to the effectiveness, colour and dimensional stability. This review aimed also to identify patients' attitudes and habits towards denture hygiene.

    Methods: Three electronic databases (MEDLINE/PubMed, Scopus and Cochrane Library) were screened, in English language, between January 1995 and December 2016. Read More

    Surface Roughness Changes in Denture Liners in Denture Stomatitis Patients.
    Int J Prosthodont 2017 November/December;30(6):561–564. Epub 2017 Oct 30.
    Purpose: This randomized clinical trial assessed how surface roughness (Ra) in resilient liners was affected by soft tissue health conditions and time-related aspects in patients with complete dentures.

    Methods: Specimens of acrylic resin (control) and denture liners (silicone-based or acrylic resin-based) were inserted into the dentures of patients with and without denture stomatitis (n = 30). Ra was evaluated before denture insertion and after 7, 14, and 21 days of prosthesis wearing. Read More

    Isolation of Candida spp. from denture-related stomatitis in Pará, Brazil.
    Braz J Microbiol 2017 Jul 29. Epub 2017 Jul 29.
    Evandro Chagas Institute, Bacteriology and Mycology Section, Mycology Laboratory, Belém, Pará 67030-000, Brazil.
    The aim of this study was to isolate and identify Candida species from the oral cavity of denture wearers with denture-related stomatitis who were attended at the University Federal of Pará (Belém City, Pará State, Brazil). A total of 36 denture wearers with denture-related stomatitis were included, and type I (50%), type II (33%) and type III (17%) stomatitis were observed. Candida spp. Read More

    Effect of Melaleuca alternifolia Mixed with Tissue Conditioners in Varying Doses on Colonization and Inhibition of Candida albicans: An In Vitro Study.
    Contemp Clin Dent 2017 Jul-Sep;8(3):446-450
    Department of Prosthodontics and Crown and Bridge, KLE VK Institute of Dental Sciences, Belgaum, Karnataka, India.
    Aims And Objectives: The study was conducted to evaluate the Colonization & Inhibition of Candida albicans in selected commercially available denture lining materials material by mixing them with varying concentrations and doses of tea tree oil.

    Materials And Methods: Five test discs of 10mm diameter and 1.5mm thickness were prepared using commercially available soft denture lining materials (Viscogel and GC-soft). Read More

    Antibiofilm Activity and Mechanism of Action of the Disinfectant Chloramine T on Candida spp., and Its Toxicity against Human Cells.
    Molecules 2017 Sep 17;22(9). Epub 2017 Sep 17.
    Graduate Program in Dentistry, School of Dentistry, Universidade Federal da Paraíba (UFPB), João Pessoa PB 58051900, Brazil.
    We evaluated the antifungal and anti-biofilm activity, mechanism of action and cytotoxicity of chloramine T trihydrate (CAT) against Candida spp. The Minimum Inhibitory and Fungicidal Concentrations (MIC/MFC) of CAT were determined. Changes in CAT-treated C. Read More

    In vivo study of antifungal effects of low-molecular-weight chitosan against Candida albicans.
    J Oral Sci 2017 ;59(3):425-430
    Department of of Oral Medicine, Faculty of Dentistry, Rafsanjan University of Medical Sciences.
    This study investigated the antifungal effects of low-molecular-weight chitosan solution on Candida albicans in denture stomatitis in comparison with nystatin suspension. This randomized, sing-leblind clinical trial included 40 patients diagnosed with denture stomatitis. Patients were divided into two groups, wherein one was treated with chitosan and the other with nystatin for 2 weeks. Read More

    Antifungal and Mechanical Properties of Tissue Conditioner Containing Plant-Derived Component: An In Vitro Study.
    J Prosthodont 2017 Sep 13. Epub 2017 Sep 13.
    Department of Oral and Maxillofacial Prosthodontics and Oral Implantology, Institute of Biomedical Sciences, Tokushima University Graduate School, Tokushima, Japan.
    Purpose: To evaluate the antifungal activity and mechanical properties of a novel antifungal tissue conditioner containing Juncus powder.

    Materials And Methods: Juncus powder was mixed with GC tissue conditioner at concentrations of 2.5%, 5. Read More

    Laboratory-Based Investigation of Denture Sonication Method in Patients with Candida-Associated Denture Stomatitis.
    J Prosthodont 2017 Sep 5. Epub 2017 Sep 5.
    National Reference Medical Mycology Laboratory, Institute of Microbiology and Immunology, Faculty of Medicine, University of Belgrade, Serbia.
    Purpose: Denture stomatitis (DS) is a disease characterized by inflammation and erythema of the oral mucosa areas covered by the denture. Multifactorial etiological factors contribute to DS, but it seems that Candida plays the key role. The aim of the study was to evaluate the denture sonication method to: (i) increase the possibility of diagnosing patients with Candida-associated DS; (ii) detect and identify the mixed Candida spp. Read More

    Inhibitory effect of zirconium oxide nanoparticles on Candida albicans adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention.
    Int J Nanomedicine 2017 28;12:5409-5419. Epub 2017 Jul 28.
    Department of Biomedical Dental Sciences, College of Dentistry, University of Dammam, Dammam, Saudi Arabia.
    Background: Despite drawbacks, cold-cured acrylic resin is still the most common material used in denture repair. Zirconia nanoparticles were among the reinforcements added to increase the strength of the resin. The effect on Candida due to the addition of zirconia nanoparticles to the resin has not been investigated. Read More

    Heat-Polymerized Resin Containing Dimethylaminododecyl Methacrylate Inhibits Candida albicans Biofilm.
    Materials (Basel) 2017 Apr 20;10(4). Epub 2017 Apr 20.
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China.
    The prevalence of stomatitis, especially caused by Candida albicans, has highlighted the need of new antifungal denture materials. This study aimed to develop an antifungal heat-curing resin containing quaternary ammonium monomer (dimethylaminododecyl methacrylate, DMADDM), and evaluate its physical performance and antifungal properties. The discs were prepared by incorporating DMADDM into the polymer liquid of a methyl methacrylate-based, heat-polymerizing resin at 0% (control), 5%, 10%, and 20% (w/w). Read More

    In Vitro Evaluation of the Inhibitory Activity of Thymoquinone in Combatting Candida albicans in Denture Stomatitis Prevention.
    Int J Environ Res Public Health 2017 Jul 8;14(7). Epub 2017 Jul 8.
    Department of Prosthetic Dental Sciences, College of Dentistry, Kind Saud University, Riyadh 11692, Saudi Arabia.
    Candida albicans adhesion and proliferation on denture bases may lead to denture stomatitis, which is a common and recurrent problem in denture wearers. The goal of this study was to assess the inhibitory effect of thymoquinone incorporated in the polymethyl methacrylate denture base material against Candida albicans. Eighty acrylic resin specimens were fabricated and divided into eight groups (n = 10) according to thymoquinone concentrations of 0. Read More

    The effect of enriching denture adhesives with chlorhexidine diacetate on the proliferation of Candida albicans: an in vitro analysis.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2 Suppl 1):45-52
    Senior Lecturer, Dept. of Oral Rehabilitation, The Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Tel Aviv, Israel.
    Denture adhesives are widely used in dentistry. The growth of Candida albicans on the denture base is common on both jaws, particularly in elderly patients. A strong correlation has been found between the growth of Candida albicans and dentures, potentially leading to denture stomatitis. Read More

    Recent Advances in Tissue Conditioners for Prosthetic Treatment. A review.
    Adv Clin Exp Med 2017 Jun 27. Epub 2017 Jun 27.
    Department of Prosthetic Dentistry, University of Medical Sciences, Poznan.
    Tissue conditioners (TCs) are short term soft liners, formed in situ from the mixture of a polymer powder and a liquid plasticizer. The article reviews recent advances in composition, functions, clinical use, gelation process, and physical properties of TCs and their effects on denture bases and oral mucosa. TCs are used to improve the fit and function of an ill-fitting denture. Read More

    Oral Candida carriage and species prevalence in denture stomatitis patients with and without diabetes.
    J Biol Regul Homeost Agents 2017 Apr-Jun;31(2):343-346
    Department of Oral Surgery and Implant Dentistry, Dental School, Johann Wolfgang Goethe, University of Frankfurt, Frankfurt, Germany.
    The objective of this study was to assess the oral Candida carriage and species prevalence in denture stomatitis (DS) patients with and without diabetes mellitus (DM). To address the focused question “In patients receiving dentures, how does having diabetes compared to no diabetes influences the carriage and species prevalence of oral Candida?” Indexed databases were explored without time or language restrictions up to and including February 2017. Nine studies were included. Read More

    The effect of nanochitosans particles on Candida biofilm formation.
    Curr Med Mycol 2016 Jun;2(2):28-33
    Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
    Background And Purpose: In people wearing dentures, the growth of various Candida species under the prosthesis leads to the formation of biofilm, which can play the role of a reservoir for Candida and other kinds of microbes. Since nano-chitosan particles can cause lasting antimicrobial activity, a more recent approach that utilizes acrylic resins with nano-chitosan particles is proposed. Therefore, we aimed to study the inhibitory effect of nano-chitosan particles on the biofilm formation of Candida species in acrylic resins. Read More

    Phagocytosis and nitric oxide production by peritoneal adherent cells in response to Candida albicans in aging: a collaboration to elucidate the pathogenesis of denture stomatitis.
    J Appl Oral Sci 2017 May-Jun;25(3):265-273
    Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Cirurgia, Estomatologia, Patologia e Radiologia. Bauru, SP, Brasil.
    Objective: The aim of this study was to investigate the influence of aging on the internalization and the production of nitric oxide (NO) by peritoneal adherent cells (PAC), in response to Candida albicans (C. albicans).

    Material And Methods: PAC obtained from young and aged mice were challenged with dead or viable C. Read More

    The Effect of Treatment of Denture-related Stomatitis on Peripheral T Cells and Monocytes.
    Oral Health Prev Dent 2017;15(3):259-268
    Purpose: Systemic immune activation has been recently linked to chronic inflammatory disorders of the oral cavity, particularly to periodontitis. The purpose of this study was to determine whether treatment of a fungus-induced oral inflammation, namely denture-related stomatitis (DRS), can affect the activation of the systemic immune response.

    Materials And Methods: Peripheral blood from patients with denture-related stomatitis caused by Candida albicans infection (n = 15) was collected at three time points: before treatment with nystatin, at the end of therapy and 2 months after finishing therapy. Read More

    Efficacy of Neem Extract and Three Antimicrobial Agents Incorporated into Tissue Conditioner in Inhibiting the Growth of C. Albicans and S. Mutans.
    J Clin Diagn Res 2017 May 1;11(5):ZC97-ZC101. Epub 2017 May 1.
    Dean and Professor and Head, Department of Conservative Dentistry, New Horizon Dental College and Research Centre, Bilaspur, Chhattisgarh, India.
    Introduction: Denture stomatitis is an inflammatory condition which compromises the mucosal surface beneath dentures. The aetiology of denture stomatitis is usually multifactorial which varies from trauma from ill fitting denture to poor immune system. There are evidences that denture stomatitis is an outcome of multispecies biofilms that include Candida albicans and Streptococcus mutans. Read More

    Photodvnamic Therapy in Endodontics.
    J Contemp Dent Pract 2017 Jun 1;18(6):534-538. Epub 2017 Jun 1.
    Department of Conservative Dentistry, Showa University Dental Hospital, Tokyo, Japan.
    Commonly used irrigants do not always eradicate the entire microbial flora in infected root canals. Therefore, several other strategies, such as photodynamic therapy (PDT) have been developed. Photoactivated disinfection is based on the interaction of a photosensitive antibacterial agent and a light source. Read More

    Nicotine Upregulates Coaggregation of Candida albicans and Streptococcus mutans.
    J Prosthodont 2017 Jun 9. Epub 2017 Jun 9.
    Department of Biomedical and Applied Sciences, Indiana University School of Dentistry, Indianapolis, IN.
    Purpose: Denture stomatitis is a condition of painless inflammation of denture-bearing mucosa. Reports indicate that nicotine, the major psychoactive ingredient in tobacco, increases growth of Streptococcus mutans and Candida albicans in denture biofilm. The purpose of this study was to determine the in vitro effects of nicotine on coaggregation of C. Read More

    The essential oil of Allium sativum as an alternative agent against Candida isolated from dental prostheses.
    Rev Iberoam Micol 2017 Jul - Sep;34(3):158-164. Epub 2017 Jun 1.
    Facultad de Estomatología Universidad Autónoma de San Luis Potosí, Mexico. Electronic address:
    Background: The colonization of the surfaces of dental prostheses by Candida albicans is associated with the development of denture stomatitis. In this context, the use of fluconazole has been proposed, but its disadvantage is microbial resistance. Meanwhile, the oil of Allium sativum has shown an effect in controlling biofilm formation by C. Read More

    Fabrication of denture base materials with antimicrobial properties.
    J Prosthet Dent 2017 May 26. Epub 2017 May 26.
    Associate Professor, Faculty of Chemical Engineering, Biotechnology Research Center, Sahand University of Technology, Tabriz, Iran.
    Statement Of Problem: Acrylic resin denture base resins are colonized by oral and nonoral bacteria and Candida species. This reservoir of microorganism causes denture stomatitis, which can be implicated in some life-threating infections in older denture wearers.

    Purpose: The purpose of this in vitro study was to incorporate quaternized N,N-dimethylaminoethyl methacrylate (DMAEMA) monomer into a denture base resin and investigate its antimicrobial and mechanical properties. Read More

    Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients.
    PLoS One 2017 11;12(5):e0176755. Epub 2017 May 11.
    Institute for Research in Dental Sciences, Faculty of Dentistry, University of Chile, Santiago, Chile.
    Candida albicans biofilms play a key role in denture stomatitis, one of the most common oral pathologies in elderly people. Because biofilms are highly resistant to antifungals, new pharmacological strategies are needed. Aspirin and nitric oxide-donor molecules have both shown antibiofilm effects on C. Read More

    Prevalence of Chronic Erythematous Candidiasis in Lebanese Denture Wearers: a Clinico-microbiological Study.
    Mater Sociomed 2017 Mar;29(1):26-29
    Department of Oral and Maxillofacial Surgery, Faculty of Dental Medicine, Lebanese University, Beirut, Lebanon.
    Objective: Chronic erythematous candidiasis also known as denture-related stomatitis refers to inflammatory changes of the denture-bearing mucosa. The aim of this study was to evaluate the prevalence of chronic erythematous candidiasis in a Lebanese population using clinical and microbiological examinations.

    Materials And Methods: Ninety-eight patients wearing full acrylic maxillary denture (50 women and 48 men) were included in this study. Read More

    The antifungal effects and mechanical properties of silver bromide/cationic polymer nano-composite-modified Poly-methyl methacrylate-based dental resin.
    Sci Rep 2017 May 8;7(1):1547. Epub 2017 May 8.
    Department of Stomatology, Kunming General Hospital of Chengdu Military Command, Teaching Hospital of Kunming Medical University, Kunming, Yunnan, China.
    Poly-methyl methacrylate (PMMA)-based dental resins with strong and long-lasting antifungal properties are critical for the prevention of denture stomatitis. This study evaluated the antifungal effects on Candida albicans ATCC90028, the cytotoxicity toward human dental pulp cells (HDPCs), and the mechanical properties of a silver bromide/cationic polymer nano-composite (AgBr/NPVP)-modified PMMA-based dental resin. AgBr/NPVP was added to the PMMA resin at 0. Read More

    Improving practice guidelines for the treatment of denture-related erythematous stomatitis: a study protocol for a randomized controlled trial.
    Trials 2017 May 5;18(1):211. Epub 2017 May 5.
    Faculty of Dental Medicine, Université de Montréal, Montreal, QC, Canada.
    Background: Denture-related erythematous stomatitis (DES) is a chronic biofilm-mediated disease, affecting one in every three complete denture wearers. Antifungals are the treatment most commonly prescribed by oral health professionals, based on the belief that colonization by Candida spp. is the main cause of DES. Read More

    Early Adhesion of Candida albicans onto Dental Acrylic Surfaces.
    J Dent Res 2017 Jul 1;96(8):917-923. Epub 2017 May 1.
    1 Biomaterials and Tissue Engineering, UCL Eastman Dental Institute, University College London, London, UK.
    Denture-associated stomatitis is a common candidal infection that may give rise to painful oral symptoms, as well as be a reservoir for infection at other sites of the body. As poly (methyl methacrylate) (PMMA) remains the main material employed in the fabrication of dentures, the aim of this research was to evaluate the adhesion of Candida albicans cells onto PMMA surfaces by employing an atomic force microscopy (AFM) single-cell force spectroscopy (SCFS) technique. For experiments, tipless AFM cantilevers were functionalized with PMMA microspheres and probed against C. Read More

    Equisetum giganteum influences the ability of Candida albicans in forming biofilms over the denture acrylic resin surface.
    Pharm Biol 2017 Dec;55(1):1698-1702
    c Department of Prosthodontics , Bauru School of Dentistry, University of São Paulo (USP) , Bauru , SP , Brazil.
    Context: Equisetum giganteum L. (Equisetaceae) is an endemic plant of Central and South America used in traditional medicine. Natural drugs have been frequently used in the treatment of a myriad of diseases, proving to be an alternative to synthetic chemicals, and have been intensively studied in the prevention of sicknesses, including oral diseases. Read More

    Effects of trimethylsilane plasma coating on the hydrophobicity of denture base resin and adhesion of Candida albicans on resin surfaces.
    J Prosthet Dent 2017 Apr 20. Epub 2017 Apr 20.
    Professor, Department of Mechanical & Aerospace Engineering, University of Missouri, Columbia, Mo.
    Statement Of Problem: Candida-associated denture stomatitis is the most common oral mucosal lesion among denture wearers. Trimethylsilane (TMS) plasma coating may inhibit the growth of Candida albicans on denture surfaces.

    Purpose: The purpose of this in vitro study was to investigate whether TMS plasma coatings can effectively reduce C albicans adhesion on denture base acrylic resin surfaces. Read More

    Efficacy of Propolis on the Denture Stomatitis Treatment in Older Adults: A Multicentric Randomized Trial.
    Evid Based Complement Alternat Med 2017 15;2017:8971746. Epub 2017 Mar 15.
    University of Brasilia (UnB), Brasilia, DF, Brazil.
    Our hypothesis tested the efficacy and safety of a mucoadhesive oral gel formulation of Brazilian propolis extract compared to miconazole oral gel for the treatment of denture stomatitis due to Candida spp. infection in older adults. Forty patients were randomly allocated in a noninferiority clinical trial into two groups. Read More

    Comparison of Candida Albicans Adherence to Conventional Acrylic Denture Base Materials and Injection Molding Acrylic Materials.
    J Dent (Shiraz) 2017 Mar;18(1):61-64
    Dept. of Prosthodontics, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.
    Statement Of The Problem: Candida species are believed to play an important role in initiation and progression of denture stomatitis. The type of the denture material also influences the adhesion of candida and development of stomatitis.

    Purpose: The aim of this study was comparing the adherence of candida albicans to the conventional and injection molding acrylic denture base materials. Read More

    The antifungal activity and cytotoxicity of silver containing denture base material.
    Niger J Clin Pract 2017 Mar;20(3):290-295
    Department of Prosthodontics, Faculty of Dentistry, Istanbul University, Istanbul, Turkey.
    Objective: Denture base materials are susceptible to fungal adhesion, which is an important etiological issue in the pathogenesis of denture stomatitis. The purpose of this in vitro study was to evaluate the antifungal activity and cytotoxicity of denture base material containing silver microparticles.

    Materials And Methods: The polymethyl methacrylate (PMMA) denture base material was used, and silver microparticles were added to the polymer powder in different concentrations by volume (0%, 0. Read More

    Oral mucosal lesions in a Chilean elderly population: A retrospective study with a systematic review from thirteen countries.
    J Clin Exp Dent 2017 Feb 1;9(2):e276-e283. Epub 2017 Feb 1.
    Gerontology Program, Faculty of Medical Sciences, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
    Background: The oral examination is an essential part of the multidisciplinary medical care in elderly people. Oral mucosal lesions and normal variations of oral anatomy (OMLs) are very common in this people, but few studies have examined the frequency and prevalence of these conditions worldwide and less in Chile. The aim of this research was to evaluate the frequency of OMLs in a Chilean elderly population. Read More

    Diminished Antimicrobial Peptide and Antifungal Antibiotic Activities against Candida albicans in Denture Adhesive.
    Antibiotics (Basel) 2017 Feb 6;6(1). Epub 2017 Feb 6.
    Iowa Institute for Oral Health Research, College of Dentistry, The University of Iowa, Iowa City, IA 52242, USA.
    The underlying causes of denture stomatitis may be related to the long-term use of adhesives, which may predispose individuals to oral candidiasis. In this study, we hypothesize that antimicrobial peptides and antifungal antibiotics have diminished anti-Candida activities in denture adhesive. To show this, nine antimicrobial peptides and five antifungal antibiotics with and without 1. Read More

    Treatment of denture-related stomatitis improves endothelial function assessed by flow-mediated vascular dilation.
    Arch Med Sci 2017 Feb 18;13(1):66-74. Epub 2016 Dec 18.
    Department of Dental Prophylaxis and Experimental Dentistry, Dental School, Jagiellonian University, Krakow, Poland; Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.
    Introduction: The presence of oral inflammation has recently been linked with the pathogenesis of cardiovascular diseases. While numerous studies have described links between periodontitis and endothelial dysfunction, little is known about the influence of denture-related stomatitis (DRS) on cardiovascular risk. Therefore, the aim of this study was to determine whether the treatment of DRS can lead to improvement of the clinical measures of vascular dysfunction. Read More

    Efficacy of photodynamic therapy in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with denture stomatitis.
    Photodiagnosis Photodyn Ther 2017 Jun 24;18:50-53. Epub 2017 Jan 24.
    Department of Prosthetic Dental Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
    Objective: The aim was to assess the efficacy of antimicrobial photodynamic therapy (aPDT) in the inactivation of oral fungal colonization among cigarette smokers and non-smokers with denture stomatitis (DS).

    Methods: A questionnaire was used to gather demographic information. Clinical oral examination was performed to determine location of denture in the jaws and oral erythematous lesions. Read More

    Synthesis, Antifungal Activity, and Biocompatibility of Novel 1,4-Diazabicyclo[2.2.2]Octane (DABCO) Compounds and DABCO-Containing Denture Base Resins.
    Antimicrob Agents Chemother 2017 Apr 24;61(4). Epub 2017 Mar 24.
    Department of Prosthodontics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    The fungal pathogen Candida albicans causes a variety of oral infections, including denture stomatitis, which is characterized by inflammation of the oral mucosa in direct contact with dentures and affects a significant number of otherwise healthy denture wearers. While antifungal treatment reduces symptoms, infections are often recurrent. One strategy to address this problem is to incorporate compounds with fungicidal activities into denture materials to prevent colonization. Read More

    Repeated applications of photodynamic therapy on Candida glabrata biofilms formed in acrylic resin polymerized.
    Lasers Med Sci 2017 Apr 14;32(3):549-555. Epub 2017 Jan 14.
    Department of Biosciences and Oral Diagnosis, Institute of Science and Technology, UNESP - Univ. Estadual Paulista, Avenida Francisco José Longo 777, São José dos Campos, 12245-000, São Paulo, Brazil.
    Previous studies have been suggested that photodynamic therapy (PDT) can be used as an adjuvant treatment for denture stomatitis. In this study, we evaluated the effects of multiple sessions of PDT on Candida glabrata biofilms in specimens of polymerized acrylic resin formed after 5 days. Subsequently, four applications of PDT were performed on biofilms in 24-h intervals (days 6-9). Read More

    The Denture-Associated Oral Microbiome in Health and Stomatitis.
    mSphere 2016 Nov-Dec;1(6). Epub 2016 Dec 28.
    School of Dentistry, University of Los Angeles at Los Angeles, Los Angeles, California, USA.
    While investigation of the microbiome on natural oral surfaces has generated a wealth of information, few studies have examined the microbial communities colonizing dentures and their relationship to oral health. To address this knowledge gap, we characterized the bacterial community associated with dentures and remaining teeth in healthy individuals and patients with denture stomatitis. The microbiome compositions of matched denture and tooth plaque samples of 10 healthy individuals and 9 stomatitis patients were determined by 16S rRNA gene pyrosequencing. Read More

    Inhibitory effects of Lactobacillus rhamnosus and Lactobacillus casei on Candida biofilm of denture surface.
    Arch Oral Biol 2017 Apr 31;76:1-6. Epub 2016 Dec 31.
    Department of Oral Microbiology and Immunology, College of Dentistry, Republic of Korea. Electronic address:
    Objective: Candida albicans biofilm is associated with denture-related stomatitis and oral candidiasis of elderly. Probiotics are beneficial bacteria and have antibacterial activity against pathogenic bacteria. The purpose of this study was to investigate the antifungal activity of various probiotics against C. Read More

    Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity.
    J Med Microbiol 2017 Jan 6;66(1):54-60. Epub 2017 Feb 6.
    1​Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK 2​Institute of Healthcare Policy and Practice, School of Health, Nursing and Midwifery, University of the West of Scotland, UK.
    Approximately 20  % of the UK population wear some form of denture prosthesis, resulting in denture stomatitis in half of these individuals. Candida albicans is primarily attributed as the causative agent, due to its biofilm -forming ability. Recently, there has been increasing evidence of C. Read More

    Cationic porphyrin-mediated photodynamic inactivation of Candida biofilms and the effect of miconazole.
    J Physiol Pharmacol 2016 Oct;67(5):777-783
    Department of Oral Pathology, University of Medical Sciences, Poznan, Poland.
    The formation of biofilms by Candida and the increasing resistance of Candida species to antifungals contribute to the high recurrence rates of denture stomatitis. This increase has stimulated an interest in antimicrobial photodynamic therapy (aPDT) as an alternative treatment. We examined the photoactivity of the porphyrin-based photosensitizer, TMP-1363, against biofilms of C. Read More

    Mater Sociomed 2016 Oct 17;28(5):392-396. Epub 2016 Oct 17.
    Department of Oral Pathology and Diagnosis, Faculty of Dentistry, Lebanese University, Beirut, Lebanon.
    Background: Denture stomatitis is a common fungal oral infection of multifactorial etiology. Denture-related factors such as denture's age, hygiene, night wearing and colonization by Candida albicans are known to predispose to denture stomatitis. The aim of this study was to evaluate these factors and their relationship with the occurrence of denture stomatitis in a Lebanese population. Read More

    Effect of sodium hypochlorite and Ricinus communis solutions on control of denture biofilm: A randomized crossover clinical trial.
    J Prosthet Dent 2017 Jun 4;117(6):729-734. Epub 2016 Dec 4.
    Professor, Department of Dental Materials and Prosthodontics, Dental School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. Electronic address:
    Statement Of Problem: The prevalence of complete edentulism remains high in the elderly, and previous data have shown that poor denture hygiene is common among patients with edentulism.

    Purpose: The purpose of this randomized crossover trial was to evaluate the efficacy of denture cleansers in terms of biofilm removal, antimicrobial action, and the remission of denture stomatitis.

    Material And Methods: Fifty denture wearers with denture stomatitis were instructed to brush their dentures (brush and soap) and to soak them (20 minutes/14 days) in 4 solutions, as follows: C (control), 0. Read More

    Correlation between age and gender in Candida species infections of complete denture wearers: a retrospective analysis.
    Clin Interv Aging 2016 21;11:1707-1714. Epub 2016 Nov 21.
    Department of Orthodontics, Institute of Dentistry, Jagiellonian University Medical College, Kraków, Poland.
    Aim: Denture-related stomatitis is a disorder that often affects denture wearers. The purpose of this study was to evaluate the intensity, genera, and frequency of yeasts in the oral cavity of complete denture wearers in terms of subject gender and age.

    Materials And Methods: Nine hundred twenty patients (307 males and 613 females) with complete upper dentures were selected for the study and divided into four age groups: ≤50 years, 51-60, 61-70, and >70 years. Read More

    Inflammatory papillary hyperplasia: A systematic review.
    Med Oral Patol Oral Cir Bucal 2017 Jan 1;22(1):e36-e42. Epub 2017 Jan 1.
    University Campus of Bellvitge, Pabellón de Gobierno, 2nd floor, office 2:29, Feixa Llarga, s/n 08907, L'Hospitalet de Llobregat, Barcelona, España,
    Introduction: Inflammatory papillary hyperplasia (IPH) is a benign lesion of the palatal mucosa. It is usually found in denture-wearers but also has been reported in patients without a history of use of a maxillary prosthesis use.

    Objectives: The aim of this study is to review the literature to assess the prevalence of denture stomatitis and inflammatory papillary hyperplasia and the etiological factors associated. Read More

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