1,604 results match your criteria Denture Stomatitis


In Vitro Assessment of Artificial Aging on the Antifungal Activity of PMMA Denture Base Material Modified with ZrO Nanoparticles.

Int J Dent 2021 13;2021:5560443. Epub 2021 May 13.

Department of Substitutive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, P.O. Box 1982, Dammam 41441, Saudi Arabia.

The antifungal effect of zirconium dioxide nanoparticles (ZrONPs) incorporated into denture base material has been inadequately investigated; additionally, to the authors' knowledge, no studies have assessed the influence of artificial aging on the antifungal activity of these particles. . Heat-polymerized acrylic resin disks were fabricated and divided into four groups (0%, 1%, 2. Read More

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Efficacy of Rose Bengal and Curcumin mediated photodynamic therapy in the treatment of denture stomatitis in patients with habitual cigarette smokers: a randomized controlled clinical trial.

Photodiagnosis Photodyn Ther 2021 Jun 1:102380. Epub 2021 Jun 1.

Department of Prosthodontics, Riyadh Elm University, Riyadh, Saudi Arabia.

Background: Cigarette smoking in conjugation with bad oral hygiene is considered a typical predisposing factor for many oral diseases including denture stomatitis. This study investigated the effect of Rose Bengal (RB)-and Curcumin (CUR)-mediated photodynamic therapy (PDT) in comparison with nystatin therapy in the intervention of denture stomatitis in cigarette smokers.

Methods: Overall, 45 habitual cigarette smokers aged ∼58 years having denture stomatitis were categorized into three groups: Group-I - RB-mediated PDT, Group-II - CUR-mediated PDT, and Group-III - Nystatin therapy. Read More

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Determining growth inhibition of Candida albicans biofilm on denture materials after application of an organoselenium-containing dental sealant.

J Prosthet Dent 2021 May 30. Epub 2021 May 30.

Professor and Director of Cariology, Department of Comprehensive Dentistry, UT Health School of Dentistry, San Antonio, Texas. Electronic address:

Statement Of Problem: Denture stomatitis is a chronic inflammatory condition caused by the formation of Candida albicans biofilm on denture bases. It is associated with aggravating intraoral pain, itching, and burning sensations. It can also potentiate cardiovascular diseases and aspiration pneumonia. Read More

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Anti candidal efficacy of commercially available triphala, neem, denture cleanser and natural aloevera leaf on heat polymerized acrylic resin.

J Indian Prosthodont Soc 2021 Apr-Jun;21(2):167-172

Department of Prosthodontics and Crown and Bridge, School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India.

Aim: The aim of the study was to evaluate the anticandidal efficacy of Triphala, aloe vera, Neem, and denture cleanser on heat polymerized acrylic resin.

Settings And Designs: In vitro - experimental study.

Materials And Methods: In this study, forty denture wearer patients were selected and were divided into four groups consisting of ten patients, namely, Group I, Group II, Group III, and Group IV, in which dentures were cleansed with denture cleanser (tablets), Triphala (churna), aloe vera (leaf), and Neem (tablets), respectively, and stored in copper containers. Read More

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Microbicidal effect of 405-nm blue LED light on Candida albicans and Streptococcus mutans dual-species biofilms on denture base resin.

Lasers Med Sci 2021 Apr 30. Epub 2021 Apr 30.

Department of Oral Medicine and Stomatology, Tsurumi University School of Dental Medicine, 2-1-3, Tsurumi, Tsurumi-ku, Yokohama, Kanagawa, 230-8501, Japan.

This study investigated: (1) the microbicidal effect of 405-nm blue LED light irradiation on biofilm formed by Candida albicans hyphae and Streptococcus mutans under dual-species condition on denture base resin, (2) the generation of intracellular reactive oxygen species (ROS) induced by irradiation, and (3) the existence of intracellular porphyrins, which act as a photosensitizer. Denture base resin specimens were prepared and C. albicans and S. Read More

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Inhibition of and Mixed Salivary Bacterial Biofilms on Antimicrobial Loaded Phosphated Poly(methyl methacrylate).

Antibiotics (Basel) 2021 Apr 13;10(4). Epub 2021 Apr 13.

Department of Engineering, Norfolk State University, Norfolk, VA 23504, USA.

Biofilms play a crucial role in the development of -associated denture stomatitis. Inhibition of microbial adhesion to poly(methyl methacrylate) (PMMA) and phosphate containing PMMA has been examined in this work. and mixed salivary microbial biofilms were compared on naked and salivary pre-conditioned PMMA surfaces in the presence or absence of antimicrobials (Cetylpyridinium chloride [CPC], KSL-W, Histatin 5 [His 5]). Read More

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A novel acrylic resin palatal device contaminated with Candida albicans biofilm for denture stomatitis induction in Wistar rats.

J Appl Oral Sci 2021 19;29:e20200865. Epub 2021 Apr 19.

Universidade Estadual de Ponta Grossa, Departamento de Odontologia, Ponta Grossa, Paraná, Brasil.

Denture stomatitis is the most frequent oral lesion in removable prosthesis wearers, with high recurrence rates and a complex treatment.

Objective: This study describes a protocol to obtain and to contaminate a palatal device with Candida albicans biofilm that could be used for an animal model of denture stomatitis.

Methodology: Acrylic resin devices (N=41) were obtained from impressions of the palates of Wistar rats with individual trays and polyether. Read More

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The Effects of Nutraceuticals and Herbal Medicine on Candida albicans in Oral Candidiasis: A Comprehensive Review.

Adv Exp Med Biol 2021 ;1308:225-248

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Candida albicans is part of the healthy flora in the oral cavity. It can also cause opportunistic infection, which can be deleterious. The most typical type of chronic oral candidiasis is denture stomatitis, and C. Read More

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Gene expression of Candida albicans strains isolates from patients with denture stomatitis submitted to treatments with photodynamic therapy and nystatin.

Photodiagnosis Photodyn Ther 2021 Apr 12:102292. Epub 2021 Apr 12.

Department of Dental Materials and Prosthodontics, School of Dentistry at Araraquara, Univ Estadual Paulista - UNESP, Rua Humaitá, 1680, 14801-903, Araraquara, SP, Brazil. Electronic address:

The study evaluated the effect of antimicrobial photodynamic therapy (aPDT) and nystatin (NYS) in the expression of genes (ACT1, ALS1, CAP1, CAT1, EFG1, HWP1, LIP3, PLB1, SAP1, and SOD1) involved in the virulence of Candida albicans strains recovered from patients with denture stomatitis (DS). These strains were isolated from the patients before (initial) and after treatment (final), and 45 days after the treatments (follow-up). For gene expression analyses, RNA was isolated from the clinical strains, followed by cDNA synthesis and qPCR using specific primers for each target gene. Read More

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Oral Candidiasis and COVID-19 in Users of Removable Dentures: Is Special Oral Care Needed?

Gerontology 2021 Apr 14:1-6. Epub 2021 Apr 14.

Department of Restorative Dentistry, Faculty of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Brazil.

Elderly patients with systemic disorders and immunocompromised patients seem to have a higher risk of developing morbidity from COVID-19. Candida albicans (C. albicans) is a potentially dangerous pathogen for these patients, especially for denture wearers with prosthetic stomatitis who require mechanical ventilation. Read More

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Fibrin Biopolymer Incorporated with Antimicrobial Agents: A Proposal for Coating Denture Bases.

Materials (Basel) 2021 Mar 26;14(7). Epub 2021 Mar 26.

Department of Periodontics and Prosthodontics, Dental School of Bauru, FOB-USP-University of São Paulo, Al. Octávio Pinheiro Brisola, 9-75, Bauru 17012-901, Brazil.

The characteristics of the denture base surface, in combination with the oral environment, promote the colonization and development of biofilm, which is the main cause of denture stomatitis. This study evaluated the effectiveness of fibrin biopolymer with digluconate chlorhexidine or alcoholic extract to prevent biofilm. Conventional heat polymerized and pre-polymerized poly(methyl methacrylate) (PMMA) circular specimens (10 × 2 mm) were fabricated ( = 504) and randomly divided into groups: no treatment (control-CT), fibrin biopolymer coating (FB), fibrin biopolymer with (FBPg), or digluconate of chlorhexidine (FBCh) coating. Read More

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Efficacy of Toluidine Blue-Mediated Antimicrobial Photodynamic Therapy on spp. A Systematic Review.

Antibiotics (Basel) 2021 Mar 25;10(4). Epub 2021 Mar 25.

Laser Laboratory Dental Surgery Department, Medical University of Wroclaw, 50-425 Wroclaw, Poland.

The effectiveness of antimicrobial photodynamic therapy (aPDT) in the treatment of oral yeast infections was examined many times in recent years. The authors of this review tried to address the question: "Should TBO (toluidine blue ortho)-mediated aPDT be considered a possible alternative treatment for oral candidiasis?". PubMed/Medline and the Cochrane Central Register of Controlled Trials (CEN-TRAL) databases were searched from 1997 up to the 27th of October 2020 using a combination of the following keywords: (Candida OR Candidiasis oral OR Candidosis oral OR denture stomatitis) AND (toluidine blue OR photodynamic therapy OR aPDT OR photodynamic antimicrobial chemotherapy OR PACT OR photodynamic inactivation OR PDI). Read More

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Treatment of oral fungal infections using photodynamic therapy: Systematic review and meta-analysis.

Clin Exp Dent Res 2021 Jun 2;7(3):354-364. Epub 2021 Apr 2.

Department of Medicine, University of Cape Town, Cape Town, South Africa.

Objectives: This systematic review evaluated the evidence for the effectiveness of Photodynamic therapy (PDT) in treating oral fungal infections, as an alternative to conventional antifungal medications.

Methods: Five randomized control trials (168 participants) comparing the treatment of oral fungal infections using met with our inclusion criteria. Clinical and microbiological improvement was assessed by random-effects meta-analysis. Read More

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Phytotherapy in the management of denture stomatitis: A systematic review and meta-analysis of randomized controlled trials.

Phytother Res 2021 Mar 9. Epub 2021 Mar 9.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Medicinal plant extracts are commonly applied for infectious diseases and are perceived as alternatives to conventional antimicrobial agents. We aimed to confirm the efficacy of phytotherapy for denture stomatitis compared with conventional therapies and placebo. A comprehensive literature search was conducted in Pubmed, Embase, Cochrane Library (CENTRAL), Scopus, and Web of Science, in addition to manual searching. Read More

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Effect of local hygiene protocols on denture-related stomatitis, biofilm, microbial load, and odor: A randomized controlled trial.

J Prosthet Dent 2021 Mar 15. Epub 2021 Mar 15.

Titular professor, Department of Dental Materials and Prosthodontics, School of Dentistry of Ribeirao Preto, University of Sao Paulo (USP), Ribeirão Preto, SP, Brazil. Electronic address:

Statement Of Problem: Denture stomatitis affects complete denture wearers and is frequently treated with antifungals drugs, as well as treating the denture with sodium hypochlorite. Whether the limitations of these treatments can be overcome with local hygiene protocols that do not damage the denture materials or adversely affect the patient is unclear.

Purpose: The purpose of this randomized controlled trial was to evaluate the effect of denture hygiene protocols on complete denture wearers with denture stomatitis. Read More

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Oral Mucosa Changes Associated with Wearing Removable Acrylic Dentures.

Curr Health Sci J 2020 Oct-Dec;46(4):344-351. Epub 2020 Dec 31.

Prosthodontics Department, University of Medicine and Pharmacy of Craiova, Romania.

The main purpose of the study was to highlight the incidence of various changes in the oral mucosa associated with wearing removable acrylic dentures. Materials and method. The study was performed on a total of 45 subjects who presented at the Prosthodontics Clinic and the Oral Rehabilitation Clinic of Craiova Faculty of Dental Medicine during January 2018-May 2020. Read More

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December 2020

Comparison of Antifungal Efficacy of Zataria Multiflora and Nystatin for Treatment of Denture Stomatitis: A Randomized Clinical Trial.

J Dent (Shiraz) 2021 Mar;22(1):60-66

Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Statement Of The Problem: Zataria multiflora (ZM) is a thyme-like plant that belongs to the Lamiaceae family. It is native to the center and south of Iran, Pakistan, and Afghanistan. Evidence shows that ZM contains thymol and carvacrol and is therefore, effective for the treatment of many conditions especially fungal infections. Read More

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Antibiofilm and Protein-Repellent Polymethylmethacrylate Denture Base Acrylic Resin for Treatment of Denture Stomatitis.

Materials (Basel) 2021 Feb 25;14(5). Epub 2021 Feb 25.

Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA.

() biofilm is a common etiological factor in denture stomatitis. The purpose of this study was to investigate the effects of incorporating 2-methacryloyloxyethyl phosphorylcholine (MPC) as a protein repellent into a new high-impact denture acrylic (HIPA) resin on the surface roughness, solution pH, and biofilm adhesion to the denture base. The new acrylic denture resin base was formulated by mixing MPC into HIPA resin at mass fractions of 1. Read More

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February 2021

Correlation between the relative abundance of oral bacteria and Candida albicans in denture and dental plaques.

J Oral Biosci 2021 Jun 1;63(2):175-183. Epub 2021 Mar 1.

Department of Removable Prosthodontics, Chikusa-ku, Nagoya, 464-8650, Japan.

Objectives: The opportunistic fungus Candida albicans is a component of denture plaque and is associated with denture-related stomatitis. Inter-kingdom interactions between C. albicans and bacteria exist in such multi-species biofilms, which may affect the microbial composition of the plaque. Read More

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Surface morphology and in vitro leachability of soft liners modified by the incorporation of antifungals for denture stomatitis treatment.

J Appl Oral Sci 2021 Feb 26;28:e20200639. Epub 2021 Feb 26.

Universidade Estadual de Ponta Grossa, Departamento de Odontologia, Ponta Grossa, Paraná, Brasil.

Objective: To evaluate the surface morphology and in vitro leachability of temporary soft linings modified by the incorporation of antifungals in minimum inhibitory concentrations (MIC) for Candida albicans biofilm.

Methodology: Specimens of soft lining materials Softone and Trusoft were made without (control) or with the addition of nystatin (Ny), miconazole (Mc), ketoconazole (Ke), chlorhexidine diacetate (Chx), or itraconazole (It) at their MIC for C. albicans biofilm. Read More

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February 2021

Patient attitude and habits regarding removable denture home hygiene and correlation with prosthesis cleanliness: A cross-sectional study of elderly Italians.

J Prosthet Dent 2021 May 26;125(5):772.e1-772.e7. Epub 2021 Feb 26.

Full Professor, Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.

Statement Of Problem: With the aging population, an increasing number of patients will require removable dental prostheses. Despite the recent public efforts to improve oral healthcare, knowledge of hygiene procedures for removable dental prostheses is sparse.

Purpose: The purpose of this cross-sectional study was to determine, through questionnaires, the level of awareness and education of home hygiene procedures among elderly Italian individuals wearing removable dental prostheses and to correlate self-reported hygiene habits and prosthesis cleanliness, as determined by a clinical examination. Read More

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Oral Hygiene Habits of Complete Denture Wearers in Central Transylvania, Romania.

Oral Health Prev Dent 2021 Jan;19(1):107-113

Purpose: To identify the oral hygiene habits and denture hygiene status (e.g. sociodemographic characteristics, general health status) of complete denture wearers in Central Transylvania, Romania. Read More

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January 2021

Microbiological evaluation of an experimental denture cleanser containing essential oil of .

Biofouling 2021 01 16;37(1):117-130. Epub 2021 Feb 16.

Department of Restorative Dentistry, Faculty of Pharmacy, Dentistry, and Nursing, Federal University of Ceará, Fortaleza, Brazil.

The antimicrobial activity of an experimental solution containing essential oil of for denture cleaning was evaluated by (1) minimum inhibitory (MIC) and fungicidal/bactericidal concentration (MFC/MBC) tests against , , and ; (2) the metabolic activity of biofilm formed on flat-bottom microplates and denture base specimens based on the reduction of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT); and (3) scanning electron microscopy, to evaluate the fungal biofilm morphology. The solution showed antimicrobial action against the pathogens tested ( - MIC and MFC: 19.53 µg ml, - MIC and MBC: 78. Read More

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January 2021

Physicomechanical, optical, and antifungal properties of polymethyl methacrylate modified with metal methacrylate monomers.

J Prosthet Dent 2021 Apr 11;125(4):706.e1-706.e6. Epub 2021 Feb 11.

Associate professor, Graduate Program in Dentistry, Pelotas Dental School, Federal University of Pelotas (UFPEL), Pelotas, Rio Grande do Sul, Brazil. Electronic address:

Statement Of Problem: The high recurrence rates of denture stomatitis may be associated with the resistance of biofilms to therapeutics. Therefore, methods that provide biomaterials with antifungal properties are an attractive solution to improving microbial control.

Purpose: The purpose of this in vitro study was to modify conventional polymethyl methacrylate (PMMA) through the incorporation of metal methacrylate monomers and to evaluate the physicomechanical and optical properties and antifungal activity of the modified materials. Read More

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The antimicrobial and antibiofilm properties of allicin against and - A therapeutic potential for denture stomatitis.

Saudi Dent J 2021 Feb 6;33(2):105-111. Epub 2020 Feb 6.

Centre of Preclinical Science Studies, Faculty of Dentistry, University Teknologi MARA Selangor, Sungai Buloh Campus, Jalan Hospital, Sungai Buloh 47000, Selangor Darul Ehsan, Malaysia.

The objective of this study is to determine the therapeutic efficacy of allicin against and (), the common etiological agents for denture stomatitis (DS). The minimum inhibitory concentration (MICs), minimum bactericidal concentrations (MBCs) and minimum fungicidal concentration (MFCs) of allicin were determined by the broth microdilution method followed by checkerboard microdilution method for a synergistic interaction between allicin + nystatin and allicin + CHX. The potential of allicin to eradicate and biofilms was assessed by treating biofilm formed on self- polymerized acrylic resin with allicin at a sub-MIC concentration for 5 min. Read More

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February 2021

Antifungal property of acrylic denture soft liner containing silver nanoparticles synthesized in situ.

J Dent 2021 03 29;106:103589. Epub 2021 Jan 29.

Department of Prosthodontics, Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, 210008, China. Electronic address:

Objectives: Denture soft liner is applied to relieve pain from candida-induced denture stomatitis and promote healing, but with shortage of antifungal activity and easily harbors fungi. To overcome this problem, the in-situ method was used to synthesize silver nanoparticles (AgNPs) in acrylic soft liner to obtain antifungal effects.

Methods: Acrylic soft-liner with various weight percentage of silver 2-ethylhexanoate (0%, 0. Read More

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Antimicrobial efficacy of silver nanoparticles against Candida albicans: A systematic review protocol.

PLoS One 2021 25;16(1):e0245811. Epub 2021 Jan 25.

Department of Restorative Dentistry, Faculty of Dentistry, University of the Western Cape, Cape Town, South Africa.

Introduction: Denture-induced stomatitis is one form of candidiasis. It is characterised as inflammation and erythema of the oral mucosa underneath the denture-bearing areas and clinically classified into three types according to severity. Denture hygiene, appropriate mouth rinses and the use of antifungal therapy are commonly used to treat the condition, but new technologies are emerging that may assist in its treatment. Read More

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January 2021

Efficacy of low-molecular weight chitosan against Candida albicans biofilm on polymethyl methacrylate resin.

Aust Dent J 2021 Jan 23. Epub 2021 Jan 23.

Department of Microbiology and Research unit on Oral Microbiology and Immunology, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

Background: Candida biofilm is a major cause of denture stomatitis. We aimed to compare the efficacy of low-molecular-weight chitosan solutions against Candida albicans biofilm on polymethyl methacrylate (PMMA) resin.

Methods: Various types of chitosan were tested for anti-Candida activity by broth dilution. Read More

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January 2021

Efficacy of essential oil of cinnamon for the treatment of oral candidiasis: A randomized trial.

Spec Care Dentist 2021 May 21;41(3):349-357. Epub 2021 Jan 21.

Departament of Clinical and Social Dentistry, Federal University of Paraíba, João Pessoa, Brazil.

Aim: It was analyzed the efficacy of mouthwash and spray containing essential oil (EO) of Cinnamomum zeylanicum Blume for the treatment of oral candidiasis.

Methods And Results: A randomized, controlled, and blinded clinical trial was conducted with 36 individuals (probabilistic sample) with oral candidiasis who were divided into two treatment groups: C. zeylanicum (0. Read More

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Effect of Denture Base Fabrication Technique on Adhesion In Vitro.

Materials (Basel) 2021 Jan 5;14(1). Epub 2021 Jan 5.

Department of Prosthodontics, Goldschleger School of Dental Medicine, Sackler Faculty of Medicine, Tel-Aviv University, Ramat-Aviv 69978, Israel.

Denture stomatitis is a common manifestation of oral candidiasis affecting some 65% of denture wearers. This condition is initiated by the adherence of to denture base acrylic resin. The present study aimed to test the in vitro effect of traditional and novel fabrication methods on adhesion to denture base samples. Read More

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January 2021