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Clin Implant Dent Relat Res 2019 Feb 19. Epub 2019 Feb 19.

The Brånemark Clinic, Public Dental Health Service, Västra Götaland, Sweden.

Background: A new implant design was launched in 2015 with internal connection allowing for placement of abutments with angulated screw channels. Such devices may eliminate the use of nonauthentic components, which may present with poor fit and jeopardize the construction. It may also eliminate the use of cemented single-crowns with the risk for excessive cement to cause marginal bone destruction. Read More

Front Pediatr 2019 4;7:15. Epub 2019 Feb 4.

Department of Child Health and Development, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is an EBV-associated lymphoproliferative disease characterized by repeated or sustainable infectious mononucleosis (IM)-like symptoms. EBV is usually detected in B cells in patients who have IM or Burkitt's lymphoma and even in patients with X-linked lymphoproliferative syndrome, which is confirmed to have vulnerability to EBV infection. In contrast, EBV infects T cells (CD4 T, CD8 T, and γδT) or NK cells mono- or oligoclonally in CAEBV patients. Read More

J Leukoc Biol 2019 Feb 18. Epub 2019 Feb 18.

Department of Oral Biology, School of Dental Medicine, University at Buffalo, Buffalo, New York, USA.

The oral cavity is a unique environment containing teeth juxtaposed with soft tissues, all of which are constantly bathed in microbial products and host-derived factors. While microbial dysbiosis in the oral cavity clearly leads to oral inflammatory disease, recent advances find that endogenous danger-associated molecular patterns (DAMPs) released from oral and salivary tissue also contribute to the progression of inflammatory and autoimmune disease, respectively. In contrast, DAMPs produced during oral fungal infection actually promote the resolution of infection. Read More

Acta Ortop Bras 2019 Jan-Feb;27(1):64-68

Department of Nuclear Engineering, Laboratório Núcleo de Radiações Ionizantes, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil.

Polymethylmetacrylte (PMMA) is used in the fields of dentistry and biomedicine as a constituent of bone cements. Hydroxyapatite (HAp) is a bioceramic produced naturally in the bones. PMMA and HAp are fundamental constituents in the preparation of bone cements. Read More

J Inflamm Res 2019 23;12:35-47. Epub 2019 Jan 23.

Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI, USA.

We postulate that the extensive cell and tissue damage inflicted by many infectious, inflammatory and post-inflammatory episodes is an enled result of a synergism among the invading microbial agents, host neutrophils and dead and dying cells in the nidus. Microbial toxins and other metabolites along with the plethora of pro-inflammatory agents released from activated neutrophils massively recruited to the infectious sites and high levels of cationic histones, other cationic peptides, proteinases and Th1 cytokines released from activated polymorphonuclear neutrophils (PMNs) and from necrotized tissues may act in concert (synergism) to bring about cell killing and tissue destruction. Multiple, diverse interactions among the many potential pro-inflammatory moieties have been described in these complex lesions. Read More

J Med Case Rep 2019 Feb 18;13(1):36. Epub 2019 Feb 18.

Department of Radiodiagnosis & Imaging, Government Medical College & Hospital, Chandigarh, India.

Introduction: Cerebral venous thrombosis is relatively rare and characterized by a wide spectrum of clinical features. It is more common in young adults with women affected more than men. The diagnosis of cerebral venous thrombosis is easier nowadays due to easy access to advanced neuroimaging techniques. Read More

Int J Pediatr Otorhinolaryngol 2019 Feb 7;120:82-88. Epub 2019 Feb 7.

Pediatrics Department, Centro Hospitalar Vila Nova de Gaia/Espinho, Portugal.

Objective: Characterize clinical features, epidemiology and treatment of hospitalized pediatric cases of preseptal and orbital cellulitis.

Methods: Retrospective study of children/adolescents admitted to a central hospital with preseptal and orbital cellulitis between 2007 and 2017.

Results: A total of 122 cases were included, 80. Read More

Bioorg Med Chem 2019 Feb 6. Epub 2019 Feb 6.

Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University (TMDU), 2-3-10 Kandasurugadai, Chiyoda-ku, Tokyo 101-0062, Japan; Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8150, Japan. Electronic address:

The chemokine receptor CXCR4/stromal cell-derived factor-1 (SDF-1: CXCL12) signaling axis represents a crucial drug target due to its relevance to several diseases such as HIV-1 infection, cancer, leukemia, and rheumatoid arthritis. With the aim of enhancing the binding affinity and anti-HIV activity of a potent CXCR4 ligand as a lead, 23 low molecular weight compounds containing dipicolylamine (Dpa) and cyclam cationic moieties with varying spacers and spatial positioning were designed, synthesized and biologically evaluated. All of the synthesized compounds screened at 1. Read More

Am J Phys Anthropol 2019 Feb 16. Epub 2019 Feb 16.

School of Anthropology and Conservation, University of Kent, Canterbury, United Kingdom.

Objectives: To compare relative response of enamel, dentin and bone to developmental stressors between attritional and catastrophic mortality assemblages of pigs.

Materials And Methods: Heads from 70 Sus scrofa of known sex, weight and age comprising an attritional sample of 50 sick pen (SP) pigs that died prematurely versus 20 control pigs slaughtered at 6 months (Catastrophic assemblage). Hard tissue changes (alveolar bone thinning), abnormal bone formation (Harris lines) and re-modeling (auditory bullae) were recorded. Read More

Arthritis Rheumatol 2019 Feb 16. Epub 2019 Feb 16.

Division of Rheumatology, Department of Medicine and Department of Pathology, Queen Elizabeth II Health Sciences Center and Dalhousie University, Halifax, Nova Scotia, Canada.

Objective: To evaluate the properties of a frailty index (FI), constructed using data from the Systemic Lupus International Collaborating Clinics (SLICC) inception cohort, as a novel health measure in SLE.

Methods: For this secondary analysis, the baseline visit was defined as the first study visit at which both organ damage (SLICC/ACR Damage Index [SDI]) and health-related quality of life (Short-Form 36 [SF-36]) were assessed. The SLICC-FI was constructed using baseline data. Read More

Virus Res 2019 Feb 12;263:179-183. Epub 2019 Feb 12.

Laboratory of RNA Viruses, Department of Virus Research, Institute for Frontier Life and Medical Sciences (inFront), Kyoto University, Kyoto, 606-8507, Japan; Department of Mammalian Regulatory Network, Graduate School of Biostudies, Kyoto University, Kyoto, 606-8507, Japan; Department of Molecular Virology, Graduate School of Medicine, Kyoto University, Kyoto, 606-8507, Japan. Electronic address:

Borna disease virus (BoDV) is a nonsegmented, negative-strand RNA virus that uniquely replicates and establishes persistent infection in cell nucleus. Recent studies have demonstrated the presence of actin in the nucleus and its role in intranuclear phenomena such as transcription and DNA repair. Although nuclear actin is involved in the life cycle of some intranuclear DNA viruses, the interaction between BoDV and nuclear actin has not been reported. Read More

J Clin Periodontol 2019 Feb 15. Epub 2019 Feb 15.

Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, China-Japan Friendship Hospital, Beijing, China.

Aim: To assess the status of periodontal health knowledge, attitudes and practices (KAP) among Chinese adults.

Materials And Methods: A cross-sectional study was conducted in a nationally representative sample of adults (N=50991) aged 20 years or older from ten provinces, autonomous regions, and municipalities. Percentages of Chinese adults with correct periodontal knowledge, positive periodontal attitudes and practices were estimated. Read More

J Prosthodont 2019 Feb 15. Epub 2019 Feb 15.

School of Pharmaceutical Sciences, University of São Paulo, Ribeirão Preto, Brazil.

Purpose: To isolate Candida spp. from dental prosthesis users' saliva and to evaluate the isolates for the presence of several virulence factors. This research also aimed to investigate the antifungal activity of 3 commercial mouthwashes/oral antiseptic formulations containing 0. Read More

Cardiovasc Res 2019 Feb 14. Epub 2019 Feb 14.

Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.

Aim: A common genetic variant at the GUCY1A3 coronary artery disease locus has been shown to influence platelet aggregation. The risk of ischaemic events including stent thrombosis varies with the efficacy of aspirin to inhibit platelet reactivity. This study sought to investigate whether homozygous GUCY1A3 (rs7692387) risk allele carriers display higher on-aspirin platelet reactivity and risk of ischaemic events early after coronary intervention. Read More

J Nanosci Nanotechnol 2019 Jul;19(7):3777-3791

The Second Hospital of Tianjin Medical University, Tianjin 300211, China.

To determine the short- and long-term antibacterial properties of a novel biomedical titanium alloy to ensure excellent biocompatibility of the TiN/Ag multilayers loaded with different doses of Ag. First, nanosized TiN/Ag multilayers were accumulated onto titanium alloy (Ti-6Al-4V) substrates via multi-arc ion plating. Then, the multilayers were implanted with different doses of silver ions (1×10 ions/cm², 1×10 ions/cm², 5×10 ions/cm², and 5×10 ions/cm²). Read More

J Stomatol Oral Maxillofac Surg 2019 Feb 11. Epub 2019 Feb 11.

Post Graduate Student Department Of Oral & Maxillofacial Surgery, K.V.G. Dental College & Hospital, Sullia, Karnataka, India.

Background: The conventional endonasal intubation would not allow precise intra-operative assessment of the changes to the nasolabial soft tissue complex. Submental intubation allows accurate measurement of nasolabial soft tissue complex with no interference with the occlusion.

Methodology: A clinical prospective study was carried on 20 patients visiting the Oral & Maxillofacial Surgery department diagnosed of dentofacial deformity requiring orthognathic surgery. Read More

Respir Investig 2019 Feb 11. Epub 2019 Feb 11.

Lung Cancer and Respiratory Disease Center, Yamanashi Prefectural Central Hospital, Japan; Division of Pulmonary Medicine, Jichi Medical University, Japan.

Background: The impact of dementia on the survival of patients with pulmonary tuberculosis (TB) remains unclear. This study sought to describe the risk factors influencing in-hospital mortality in patients with pulmonary TB and comorbid dementia.

Methods: A 9-y, medical record-based retrospective study of hospitalized adult patients with newly diagnosed, smear-positive, non-multidrug-resistant pulmonary TB without human immunodeficiency virus infection was performed. Read More

PLoS One 2019 13;14(2):e0212443. Epub 2019 Feb 13.

Department of Biological Sciences, Rowan University, Glassboro, New Jersey, United States of America.

Regulation of Natural Killer (NK) cell activity is achieved by the integration of both activating and inhibitory signals acquired at the immunological synapse with potential target cells. NK cells express paired receptors from the immunoglobulin family which share common ligands from the nectin family of adhesion molecules. The activating receptor CD226 (DNAM-1) binds to nectin-2 and CD155, which are also recognized by the inhibitory receptor TIGIT. Read More

Ann Am Thorac Soc 2018 Dec;15(Supplement_4):S286

1 Minneapolis Veterans Affairs Medical Center, Minneapolis, Minnesota; and.

Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease. COPD frequent exacerbators (FEs) suffer increased morbidity and mortality compared with infrequent exacerbators (IEs). Exacerbations are associated with bacterial infection and lung inflammation. Read More

Hip Int 2018 Nov;28(2_suppl):61-65

1 Franco Scalabrino Orthopaedic Institute of Southern Italy, Messina, Italy.

Introduction:: Severe acetabular bone loss during revision hip arthroplasty can be restored with different surgical techniques. Best results have been observed using porous tantalum cementless cups. Trabecular Titanium (TT) cups were designed to reproduce the structure, mechanical and biological characteristics of trabecular bone. Read More

Acta Biomater 2019 Feb 10. Epub 2019 Feb 10.

MDRCBB-Minnesota Dental Research Center for Biomaterials and Biomechanics, Department of Restorative Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN, USA. Electronic address:

Dental caries, i.e., tooth decay mediated by bacterial activity, is the most widespread chronic disease worldwide. Read More

Photodiagnosis Photodyn Ther 2019 Feb 9. Epub 2019 Feb 9.

Oral Microbiology Laboratory, Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: To investigate the efficacy of antimicrobial photodynamic therapy (aPDT) adjunctive to conventional chemo-mechanical debridement of root canal system in patients with endodontic infections.

Methods: A meta-analysis was done according to the Cochrane Collaboration recommendations and PRISMA statement. Two independent reviewers performed an extensive literature search on electronic databases of MEDLINE, EMBASE, and SCOPUS up to January 2019. Read More

Clin Infect Dis 2019 Feb 7. Epub 2019 Feb 7.

Department of Biology, Percy Military Teaching Hospital, Clamart, France.

Background: Mycobacterium canettii forms part of the Mycobacterium tuberculosis complex. M. canettii infections are mainly described in the Horn of Africa. Read More

Sci Adv 2019 Jan 23;5(1):eaau3333. Epub 2019 Jan 23.

Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland.

, the keystone pathogen in chronic periodontitis, was identified in the brain of Alzheimer's disease patients. Toxic proteases from the bacterium called gingipains were also identified in the brain of Alzheimer's patients, and levels correlated with tau and ubiquitin pathology. Oral infection in mice resulted in brain colonization and increased production of Aβ, a component of amyloid plaques. Read More

World J Clin Cases 2019 Feb;7(3):270-290

Renal Transplantation, Barts Health NHS Trust, Royal London Hospital, London E1 1BB, United Kingdom.

Background: Polyomavirus-associated nephropathy is a leading cause of kidney allograft failure. Therapeutic options are limited and prompt reduction of the net state of immunosuppression represents the mainstay of treatment. More recent application of aggressive screening and management protocols for BK-virus infection after renal transplantation has shown encouraging results. Read More

J Cell Sci 2019 Feb 11. Epub 2019 Feb 11.

Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK

Mesenchymal stromal cells (MSC) up-regulate podoplanin at sites of infection, chronic inflammation, and cancer. We investigated the functional consequences of podoplanin expression on the migratory potential of MSC and their interactions with circulating platelets. Expression of podoplanin significantly enhanced the migration of MSC compared to MSC lacking podoplanin. Read More

J Prosthet Dent 2019 Feb 8. Epub 2019 Feb 8.

Associate Professor, Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine, Boston, Mass.

A procedure for registering digital intraoral surface scans onto cone beam computed tomography in the presence of significant scatter artifact is described. The technique uses chairside-fabricated composite resin markers placed on well-distributed teeth to serve as common landmarks in each digital data set for accurate registration. This straightforward, noninvasive, and cost-effective technique facilitates registration without the need for a specialized armamentarium or radiographic templates. Read More

Environ Res 2019 Apr 11;171:523-529. Epub 2019 Jan 11.

Children's Environmental Health and Disease Prevention Research Center at Dartmouth, Hanover, NH, USA; Department of Epidemiology, Geisel School of Medicine at Dartmouth, Lebanon, NH, USA. Electronic address:

Background: Mechanistic studies support the potential for mercury (Hg) to alter immunity, including via in utero exposure. As yet, there are few prospective studies of in utero Hg exposure and subsequent immune-related outcomes, especially in infancy.

Objectives: We investigated the association of biomarkers of prenatal Hg exposure and maternal silver-mercury dental amalgams with the occurrence of infant allergy, respiratory infection, and respiratory symptoms in the first year of life. Read More

Eur J Haematol 2019 Feb 10. Epub 2019 Feb 10.

Department of Hematology, National Cancer Center Hospital, Tokyo, Japan, 5-1-1 Tsukiji, Chuo-ku, Tokyo, 104-0045, Japan.

Objective: This prospective, observational, postmarketing surveillance was conducted to evaluate the safety and effectiveness of mogamulizumab, an anti-CC chemokine receptor 4 (CCR4) monoclonal antibody, in patients with CCR4-positive, relapsed or refractory (r/r) adult T-cell leukemia-lymphoma (ATL) in Japan.

Method: All patients were scheduled to receive intravenous infusions of mogamulizumab 1.0 mg/kg once weekly for 8 weeks, alone or in combination with other modalities. Read More

Asia Pac Allergy 2019 Jan 14;9(1):e3. Epub 2019 Jan 14.

Department of Pediatrics, Nippon Medical School Musashi Kosugi Hospital, Kanagawa, Japan.

Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and atopic eczema. The patient was a 11-month-old boy admitted to our hospital with pyrexia for 2 weeks. Read More

J Infect Public Health 2019 Feb 6. Epub 2019 Feb 6.

University of Bath, Bath, United Kingdom.

Like other low-income countries, limited data are available on the use of personal protective equipment (PPE) in Pakistan. We conducted a systematic review of studies on PPE use for respiratory infections in healthcare settings in Pakistan. MEDLINE, Embase and Goggle Scholar were searched for clinical, epidemiological and laboratory-based studies in English, and 13 studies were included; all were observational/cross-sectional studies. Read More

Int J Oral Maxillofac Surg 2019 Feb 6. Epub 2019 Feb 6.

Oral and Maxillofacial Surgery Department, Dental School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Antibacterial coating of surgical sutures is a suggested approach to prevent surgical site infections. The aim of this study was to compare the incidence of surgical site infection following the use of polyglactin 910 (Vicryl) and polyglactin 910 coated with triclosan (Vicryl Plus) sutures in dental implant surgery. This single-blind, randomized clinical trial evaluated patients who received three implants in the posterior mandible. Read More

Int Immunopharmacol 2019 Feb 6;69:202-212. Epub 2019 Feb 6.

Department of Pharmacology, Ehime University Graduate School of Medicine Shitsukawa, Toon, Ehime 791-0295, Japan.

Chèdiak-Higashi syndrome is a rare autosomal recessive disease that causes hypopigmentation, recurrent infections, mild coagulation defects and neurological problems. Beige mice carry a mutation in the lysosome trafficking regulator (LYST) gene and display some of the key characteristics of human Chèdiak-Higashi syndrome, in particular, a high susceptibility to infection due to aberrant natural killer (NK) cell and polymorphonuclear leucocyte function. Morphological analysis of beige mice reveals the presence of enlarged lysosomes in a variety of cell types, including leucocytes, hepatocytes, fibroblasts and renal tubule cells. Read More

Wiad Lek 2018 ;71(9):1645-1652

Ukrainian Medical Stomatological Academy, Poltava, Ukraine.

Objective: Introduction: Dental implantation in conditions of bone deficiency in the loss of lateral group of teeth of the upper jaw is impossible without the maxillary sinus floor augmentation. Preparation for surgical intervention requires a thorough assessment of the anatomical features of the sinus, relationship between the sinus and adjacent teeth, detection of foci of chronic infection of the Schneiderian membrane. In the complex of the objective methods of investigation, computed tomography is the most informative approach to study the state of the bone and soft tissue structure of the sinus. Read More

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Medicine, University of Washington, Seattle, Washington, USA.

The role of antibiotic prophylaxis for prevention of infective endocarditis is unknown. Endocarditis prophylaxis is recommended for certain high-risk individuals prior to dental procedures. To our knowledge, this is the first case reported in the literature of a patient with complex congenital heart disease developing endocarditis in the period immediately following otherwise uncomplicated intrauterine device insertion. Read More

BMC Pulm Med 2019 Feb 8;19(1):34. Epub 2019 Feb 8.

Section of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.

Background: Hyperimmunoglobulin E syndrome (HIES) is a rare primary immunodeficiency disorder defined by high serum immunoglobulin E titers that is associated with recurrent respiratory infections, formation of pneumoatoceles, recurrent skin abscesses, and characteristic dental and skeletal abnormalities.

Case Presentation: We report a case of a 56-year-old male with a history of HIES, cavitary mycetomas, and allergic bronchopulmonary aspergillosis who presented with recurrent massive hemoptysis. Bronchial artery angiography and bronchoscopy failed to identify active hemorrhage, and two embolizations of the bronchial artery did not resolve the bleeding. Read More

Hum Vaccin Immunother 2019 Feb 8. Epub 2019 Feb 8.

a College of Public Health , University of South Florida , Tampa , FL , USA.

Evidence suggests a causal connection between the Human Papillomavirus (HPV) and oropharyngeal cancers. HPV-related oropharyngeal cancers are increasing and are the most common HPV-associated cancer. Previous research suggests that dental professionals recognize a role in the prevention of HPV and oropharyngeal cancers. Read More

J Periodontal Res 2019 Feb 8. Epub 2019 Feb 8.

Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University, Amsterdam, The Netherlands.

Background And Objective: Metal-based dental restorations with a subgingival outline may enhance plaque accumulation and bacterial colonization. This study aimed to investigate whether metal-based restorations influence the composition of subgingival microbiome.

Material And Methods: Per subject one site with a metal-based restoration and one contra-lateral site without a restoration were selected on basis of radiographic bone loss ≤2 mm, restoration outline at sulcus level/subgingivally, pocket depth ≤4 mm, and no root canal treatments. Read More

BMC Infect Dis 2019 Feb 7;19(1):127. Epub 2019 Feb 7.

University Hospital for Infectious Diseases "Dr. Fran Mihaljević", Mirogojska 8, 10000, Zagreb, Croatia.

Background: Tumor necrosis factor-α (TNF-α) antagonists, most of which are monoclonal antibodies, became a widespread treatment for autoimmune diseases such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel diseases, psoriasis, psoriatic arthritis, hidradenitis suppurativa and uveitis. Their use is based on the blockage of TNF-α, which plays an important role in granulomas formation, development of phagosomes, activation and differentiation of macrophages, immune response against viral pathogens. The multiple adverse effects of TNF-α inhibition have been identified, including a two-to four-fold increased risk of active tuberculosis and other granulomatous conditions and an increased occurrence of some other serious bacterial, fungal and certain viral infections. Read More

Medicine (Baltimore) 2019 Feb;98(6):e14313

Virology Department, Noguchi Memorial Institute for Medical Research, College of Health Sciences.

Antiretroviral therapy (ART) and drug resistance studies worldwide have focused almost exclusively on human immunodeficiency virus type 1 (HIV-1). As a result, there is limited information on ART and drug resistance in HIV-2 patients. In Ghana, the HIV epidemic is characterized by the domination of HIV-1, with cocirculating HIV-2. Read More

PLoS Pathog 2019 Feb 7;15(2):e1007551. Epub 2019 Feb 7.

Centre for Membrane Interactions and Dynamics, Department of Biomedical Sciences, University of Sheffield, Firth Court, Western Bank, Sheffield, United Kingdom.

By engulfing potentially harmful microbes, professional phagocytes are continually at risk from intracellular pathogens. To avoid becoming infected, the host must kill pathogens in the phagosome before they can escape or establish a survival niche. Here, we analyse the role of the phosphoinositide (PI) 5-kinase PIKfyve in phagosome maturation and killing, using the amoeba and model phagocyte Dictyostelium discoideum. Read More

Crit Rev Microbiol 2019 Feb 7:1-25. Epub 2019 Feb 7.

b Department of Prosthodontics, Manipal College of Dental Sciences , Manipal Academy of Higher Education , Manipal , Karnataka , India.

Periodontitis is a potential source of permanent systemic inflammation that initiates renal dysfunction and contributes to the development of chronic kidney diseases (CKDs). Although numerous studies have confirmed the bidirectional role of periodontal infection and renal inflammation, no literature has yet highlighted the sophisticated pathogenic mechanisms by which periodontal pathogens, particularly Porphynomonas Gingivalis, induce renal dysfunction and contributed in the development of CKDs. The present review aims to critically analyze and highlight the novel pathogenesis of periodontitis induced CKDs. Read More

Eur J Dent Educ 2019 Feb 6. Epub 2019 Feb 6.

Department of Epidemiology and Clinical Microbiology, National Medicines Institute, Chelmska 30/34, 00-725, Warsaw, Poland.

Introduction: Antimicrobial resistance has been one of the biggest global concerns. Dentists constitute an important group of antibiotic prescribers and it was shown that their therapeutic decisions are not always rational. In this paper we present knowledge of antibiotics prescription rules and antimicrobial resistance among graduating dentistry students from all dentistry faculties of medical universities in Poland, who will soon join the group of antibiotics prescribers. Read More

J Maxillofac Oral Surg 2019 Mar 14;18(1):65-72. Epub 2017 Dec 14.

Department of Oral and Maxillofacial Surgery, SCB Dental College and Hospital, Cuttack, Odisha India.

Aim: To study whether the use of 3-D miniplate, when compared with conventional miniplate, gives better clinical outcomes with fewer complications in patients with fracture mandible.

Materials And Methods: A prospective study was conducted in the Department of Oral and Maxillofacial Surgery, Trauma Care Centre, on 40 patients. They were randomly divided into Group-I and Group-II with 20 patients in each group. Read More

J Maxillofac Oral Surg 2019 Mar 14;18(1):30-33. Epub 2017 Dec 14.

3Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Medical Sciences and Technology, Khartoum, Sudan.

Background: Orbital infection related to mandibular third molar infection is extremely rare. Most of cases reported in literature are related to maxillary molar teeth. Odontogenic infections are not common causes of orbital abscess but it should always be put in consideration when dealing with orbital cellulitis and abscess. Read More

J Maxillofac Oral Surg 2019 Mar 26;18(1):23-29. Epub 2017 Jun 26.

Department of Oral & Maxillofacial Surgery, Government Dental College & Hospital Srinagar, Srinagar, Jammu and Kashmir India.

Aim: To assess the safety and effectiveness of superficial cervical plexus (SCP) block in oral and maxillofacial surgical (OMFS) practice as an alternative to general anesthesia in selective cases.

Subjects And Methods: The total number of patients was 10, out of which 6 were male and 4 were female patients. Five patients had incision and drainage of perimandibular space infections, two patients had enucleation of cyst in the body of mandible, one patient had open reduction and internal fixation isolated angle fracture, and two patients had submandibular lymph node biopsies. Read More

JCI Insight 2019 Feb 7;4(3). Epub 2019 Feb 7.

Institute of Human Nutrition, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, USA.

Fusobacterium nucleatum is an oral anaerobe prevalent in intrauterine infection associated with a wide spectrum of adverse pregnancy outcomes. We demonstrate here that F. nucleatum triggers placental inflammation through maternal, rather than paternal, TLR4-mediated signaling. Read More

Acta Haematol 2019 Feb 6;141(2):111-118. Epub 2019 Feb 6.

Department of Medical Oncology, Ibaraki Prefectural Central Hospital, Kasama,

We assessed the efficacy and safety of weekly cyclophosphamide-bortezomib-dexamethasone (CBD) induction prior to autologous stem cell transplantation (ASCT) in newly diagnosed Japanese patients with multiple myeloma (MM). This regimen consisted of four 28-day cycles of once-weekly oral cyclophosphamide (300 mg/m2), subcutaneous bortezomib (1.3 mg/m2), and oral dexamethasone (40 mg). Read More

Rinsho Ketsueki 2019 ;60(1):7-11

Department of Hematology, Tokyo Medical and Dental University.

A 54-year-old female complained of oral erosion. A flaccid blister appeared on the trunk 2 months after the onset. The high titer of the anti-desmoglein 1 antibody in the absence of Nikolsky's sign led to the diagnosis of pemphigus vulgaris. Read More

Cell Rep 2019 Feb;26(6):1614-1626.e5

Department of Microbiology, University of Pennsylvania School of Dental Medicine, Philadelphia, PA 19104, USA. Electronic address:

β2-integrins promote neutrophil recruitment to infected tissues and are crucial for host defense. Neutrophil recruitment is defective in leukocyte adhesion deficiency type-1 (LAD1), a condition caused by mutations in the CD18 (β2-integrin) gene. Using a model of Citrobacter rodentium (CR)-induced colitis, we show that CD18 mice display increased intestinal damage and systemic bacterial burden, compared to littermate controls, ultimately succumbing to infection. Read More