32,640 results match your criteria Dental Infections


Underestimation of co-infections in COVID-19 due to non-discriminatory use of antibiotics.

J Infect 2020 Jul 3. Epub 2020 Jul 3.

International Genome Centre, Jiangsu University, Zhenjiang, China; Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur, Malaysia.

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http://dx.doi.org/10.1016/j.jinf.2020.06.077DOI Listing

COVID-19 dentistry-related aspects: a literature overview.

Int Dent J 2020 Jul 5. Epub 2020 Jul 5.

Unit of Dentistry and Oral-Maxillo-Facial Surgery, Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy.

A new coronavirus (Sars-CoV-2) was detected in China at the end of 2019 and has since caused a worldwide pandemic. This virus is responsible for an acute respiratory syndrome (COVID-19), distinguished by a potentially lethal interstitial bilateral pneumonia. Because Sars-CoV-2 is highly infective through airborne contamination, the high infection risk in the dental environment is a serious problem for both professional practitioners and patients. Read More

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http://dx.doi.org/10.1111/idj.12601DOI Listing

Efficient T cell compartment in HIV+ patients receiving orthotopic liver transplant and immunosuppressive therapy.

J Infect Dis 2020 Jul 4. Epub 2020 Jul 4.

Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, Modena, Italy.

Background And Aims: In patients undergoing orthotopic liver transplant (OLT), immunosuppressive (IS) treatment is mandatory and infections are leading causes of morbidity/mortality. Thus, it is essential to understand the functionality of cell-mediated immunity after OLT. The aim of the study was to identify changes in T cell phenotype and polyfunctionality in HIV+ and HIV- patients treated with IS after OLT. Read More

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http://dx.doi.org/10.1093/infdis/jiaa395DOI Listing

The apical root canal system microbial communities determined by next-generation sequencing.

Sci Rep 2020 Jul 2;10(1):10932. Epub 2020 Jul 2.

School of Dental Medicine, School of Engineering and Applied Sciences, Center for Innovation and Precision Dentistry, University of Pennsylvania, Philadelphia, USA.

The aim of this study was to explore the microbial communities of endodontic infections at their apical portion by 16S rRNA Illumina sequencing and delineate the core microbiome of root canal infections and that of their associated clinical symptomatology. Samples were collected from fifteen subjects presenting one tooth with a root canal infection, and their associated symptoms were recorded. Samples were collected from the apical third of roots using a #10 K file and then amplified using multiple displacement amplification and PCR-amplified with universal primers. Read More

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http://dx.doi.org/10.1038/s41598-020-67828-3DOI Listing

Immune status, and not HIV infection or exposure, drives the development of the oral microbiota.

Sci Rep 2020 Jul 2;10(1):10830. Epub 2020 Jul 2.

Institute of Human Virology, University of Maryland School of Medicine, Baltimore, MD, USA.

Even with antiretroviral therapy, children born to HIV-infected (HI) mothers are at a higher risk of early-life infections and morbidities including dental disease. The increased risk of dental caries in HI children suggest immune-mediated changes in oral bacterial communities, however, the impact of perinatal HIV exposure on the oral microbiota remains unclear. We hypothesized that the oral microbiota of HI and perinatally HIV-exposed-but-uninfected (HEU) children will significantly differ from HIV-unexposed-and-uninfected (HUU) children. Read More

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http://dx.doi.org/10.1038/s41598-020-67487-4DOI Listing

Determination of Antimicrobial Prescribing Practices in an Integrated Health System Emergency Department.

Kans J Med 2020 25;13:131-133. Epub 2020 Jun 25.

University of Kansas School of Medicine, Kansas City, KS.

Introduction: Antibiotic stewardship utilizes interprofessional collaborative practices, including professionals from medicine, pharmacy, nursing, social services, and clinical laboratory science, to identify potential problems proactively. A tertiary care integrated health system's Emergency Department (ED) aimed to identify antimicrobials prescribed to the outpatient community as part of a proactive antimicrobial stewardship project.

Methods: A pilot, prospective, snapshot of a tertiary community hospital's outpatient antimicrobial prescribing habits was conducted. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324061PMC

evaluation of zinc oxide-propolis mixture as root canal filling material in the primary molars: A 24-month follow-up randomized controlled trial.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):171-176

Department of Pedodontics and Preventive Dentistry, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.

Background: Pulpectomy is a routine practice in children with pulpal and periapical infections, the success of which depends on the elimination of bacteria from the root canals. Propolis, a natural product with proven antibacterial and anti-inflammatory properties when mixed with zinc oxide powder as root canal filling material, it could provide good success in endodontic therapy of primary teeth.

Aim: The aim was to evaluate and compare the clinical effectiveness of zinc oxide-propolis mixture with zinc oxide eugenol (ZOE) as root canal filling material in nonvital primary molars. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_127_20DOI Listing

evaluation of antimicrobial effect of fragrans on common endodontic pathogens.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):145-151

Department of Drugs Control, Government of Karnataka, Bengaluru, Karnataka, India.

Background: Complete elimination of microorganisms from the root canals is the important key for the successful endodontic treatment. Constant emergence of resistant strains and adverse effects of synthetic drugs has led to the search of effective herbal alternatives. Nutmeg (Myristica fragrans) is one such spice used for its various medicinal activities. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_214_20DOI Listing

Pattern of antibiotic prophylaxis practice for dental procedures in children with congenital heart disease.

J Indian Soc Pedod Prev Dent 2020 Apr-Jun;38(2):126-131

Department of Paediatric Dentistry, Institute of Paediatric, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia.

Background: Various antibiotic prophylaxis guidelines have been published such as the American Heart Association 2007, British Society for Antimicrobial Chemotherapy 2006, National Institute for Health and Clinical Excellence 2008, European Society of Cardiology 2015, and in Malaysia, the National Antibiotic Guideline 2014 and Clinical Practice Guidelines for the Prevention, Diagnosis and Management of Infective Endocarditis 2017. The aim of the study is to determine the pattern of antibiotic prophylaxis practice for dental procedure in children with congenital heart disease (CHD) at the Department of Paediatric Dentistry, Kuala Lumpur Hospital.

Materials And Methods: A comparative cross-sectional study of dental records from 2010 to 2015 was done by collecting data on the source and reason of referral, types of heart condition, dental procedure, and antibiotic given. Read More

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http://dx.doi.org/10.4103/JISPPD.JISPPD_235_18DOI Listing

Screening for Dental Infections Achieves 6-Fold Reduction in Dental Emergencies During Induction Chemotherapy for Acute Myeloid Leukemia.

JCO Oncol Pract 2020 Jul 1:OP2000107. Epub 2020 Jul 1.

Department of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Purpose: Patients with newly diagnosed acute myeloid leukemia (AML) are at risk of infection, including odontogenic infections, during induction chemotherapy. It is unknown whether clinical dental screening to diagnose and treat odontogenic disease in these patients can reduce the incidence of dental emergencies.

Methods: Between November 1, 2014, and December 31, 2016, we screened 147 patients with newly diagnosed AML before their admission for induction chemotherapy (n 147, "screened" group). Read More

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http://dx.doi.org/10.1200/OP.20.00107DOI Listing

[Infection prevention in dental care during the outbreak of SARS-CoV-2].

Ned Tijdschr Tandheelkd 2020 May;127(5):309-317

COVID-19 is an emerging infectious disease with widespread transmission of the coronavirus SARS-CoV-2 in the Netherlands. Some of those infected become seriously ill. Others do not show any symptoms, but can still contribute to the transmission of the virus. Read More

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http://dx.doi.org/10.5177/ntvt.2020.05.20031DOI Listing

[Influence of different type of toothbrushes on gingival fluid proteolytic potential during orthodontic treatment].

Stomatologiia (Mosk) 2020 ;99(3):22-26

Rostov State Medical University of Ministry of Health of the Russian Federation, Rostov-on-Don, Russia.

The Aim: To study the effect of toothbrushes of various types on the accumulation of plaque and the proteolytic potential of gingival fluid as a pathogenic factors in long-term orthodontic treatment of patients with a distal permanent bite.

Material And Methods: We examined 63 patients of both sexes aged 11-18 years. Orthodontic treatment was carried out for the close position of the teeth with a distal permanent bite (K07. Read More

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http://dx.doi.org/10.17116/stomat20209903122DOI Listing

COVID-19 and Dentistry: Prevention in Dental Practice, a Literature Review.

Int J Environ Res Public Health 2020 06 26;17(12). Epub 2020 Jun 26.

Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy.

SARS-CoV-2 is a member of the family of coronaviruses. The first cases were recorded in Wuhan, China, between December 2019 and January 2020. Italy is one of the most affected countries in Europe. Read More

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http://dx.doi.org/10.3390/ijerph17124609DOI Listing

Assessment of the antibacterial, antivirulence, and action mechanism of Copaifera pubiflora oleoresin and isolated compounds against oral bacteria.

Biomed Pharmacother 2020 Jun 27;129:110467. Epub 2020 Jun 27.

Laboratory of Research in Applied Microbiology (LaPeMA), University of Franca, Franca, SP 14404-600, Brazil; Laboratory of Antimicrobial Testing (LEA), Institute of Biomedical Sciences, Federal University of Uberlândia, Uberlândia, MG 38405-320, Brazil. Electronic address:

The microorganisms that constitute the oral microbiome can cause oral diseases, including dental caries and endodontic infections. The use of natural products could help to overcome bacterial resistance to the antimicrobials that are currently employed in clinical therapy. This study assessed the antimicrobial activity of the Copaifera pubiflora oleoresin and of the compounds isolated from this resin against oral bacteria. Read More

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http://dx.doi.org/10.1016/j.biopha.2020.110467DOI Listing

Autosomal recessive complete STAT1 deficiency caused by compound heterozygous intronic mutations.

Int Immunol 2020 Jun 30. Epub 2020 Jun 30.

Department of Pediatrics, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan.

Autosomal recessive (AR) complete signal transducer and activator of transcription 1 (STAT1) deficiency is an extremely rare primary immunodeficiency that causes life-threatening mycobacterial and viral infections. Only seven patients from five unrelated families with this disorder have been so far reported. All causal STAT1 mutations reported are exonic and homozygous. Read More

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http://dx.doi.org/10.1093/intimm/dxaa043DOI Listing

Advances in Antimicrobial Microneedle Patches for Combating Infections.

Adv Mater 2020 Jun 29:e2002129. Epub 2020 Jun 29.

Institute for Polymers, Composites, and Biomaterials (IPCB), National Research Council (CNR), Naples, 80125, Italy.

Skin infections caused by bacteria, viruses and fungi are difficult to treat by conventional topical administration because of poor drug penetration across the stratum corneum. This results in low bioavailability of drugs to the infection site, as well as the lack of prolonged release. Emerging antimicrobial transdermal and ocular microneedle patches have become promising medical devices for the delivery of various antibacterial, antifungal, and antiviral therapeutics. Read More

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http://dx.doi.org/10.1002/adma.202002129DOI Listing

Development of a Deep Learning Algorithm for Periapical Disease Detection in Dental Radiographs.

Diagnostics (Basel) 2020 Jun 24;10(6). Epub 2020 Jun 24.

Laboratory for Innovation Science, Harvard University, 175 N. Harvard Street, Suite 1350, Boston, MA 02134, USA.

Periapical radiolucencies, which can be detected on panoramic radiographs, are one of the most common radiographic findings in dentistry and have a differential diagnosis including infections, granuloma, cysts and tumors. In this study, we seek to investigate the ability with which 24 oral and maxillofacial (OMF) surgeons assess the presence of periapical lucencies on panoramic radiographs, and we compare these findings to the performance of a predictive deep learning algorithm that we have developed using a curated data set of 2902 de-identified panoramic radiographs. The mean diagnostic positive predictive value (PPV) of OMF surgeons based on their assessment of panoramic radiographic images was 0. Read More

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http://dx.doi.org/10.3390/diagnostics10060430DOI Listing

Long-term outcomes of cultivated cell sheet transplantation for treating total limbal stem cell deficiency.

Ocul Surf 2020 Jun 26. Epub 2020 Jun 26.

Department of Ophthalmology, Tokyo Dental College, Ichikawa General Hospital, Japan; Cornea Center Eye Bank, Tokyo Dental College, Ichikawa General Hospital, Japan; Department of Ophthalmology, Keio University School of Medicine, Japan.

Purpose: This study was conducted to determine the long-term outcomes of cultivated cell sheet transplantation (CCST), and to clarify risk factors that affected the outcomes.

Methods: We retrospectively analyzed the medical charts and photographs of 246 consecutive surgeries (162 eyes from 139 patients) that used CCST for treating total limbal stem cell deficiency. Deficiency types included Stevens-Johnson syndrome (SJS) or toxic epidermal necrolysis (TEN; n = 80), ocular surface burns (Burn; n = 75), ocular cicatricial pemphigoid (OCP) or pseudo-OCP (n = 58), and others (n = 33). Read More

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http://dx.doi.org/10.1016/j.jtos.2020.06.005DOI Listing

Nationwide survey of systemic chronic active EBV infection in Japan in accordance with the new WHO classification.

Blood Adv 2020 Jul;4(13):2918-2926

Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Bunkyo-ku, Tokyo, Japan.

Systemic chronic active Epstein-Barr virus infection (sCAEBV) was defined as a T- or NK-cell neoplasm in the 2017 World Health Organization (WHO) classification. To clarify the clinical features of sCAEBV under this classification and review the effects of chemotherapy, we performed a nationwide survey in Japan from 2016 through 2018 of patients with sCAEBV newly diagnosed from January 2003 through March 2016. One hundred cases were evaluated. Read More

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http://dx.doi.org/10.1182/bloodadvances.2020001451DOI Listing

Dental Caries and Otitis Media Among Schoolchildren in Palau.

Hawaii J Health Soc Welf 2020 Jun;79(6 Suppl 2):33-39

Office of Health Policy, Research, & Development, Ministry of Health, Republic of Palau (IBA, BMW).

Both oral disease and middle ear infections are highly prevalent in Pacific Island children. These diseases are multifactorial and likely attributable in part to both social and environmental factors. It has been two decades since these diseases were defined in Palau, and at the time were noted to be among the most common conditions and presented a substantial burden among Palau's children. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311932PMC

What Do the Dental Students Know about Infection Control? A Cross-Sectional Study in a Teaching Hospital, Rawalpindi, Pakistan.

Biomed Res Int 2020 1;2020:3413087. Epub 2020 Jun 1.

Foundation University Medical College, Rawalpindi, Pakistan.

Background: Dental students are exposed to various infections and infective sources during their training, and on this aspect, their level of knowledge is suboptimal and practices are risky. Therefore, improving their knowledge and practices would contribute significantly to infection control.

Objective: To ascertain the level of understanding of senior dental students regarding the infection control in the dental practice. Read More

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http://dx.doi.org/10.1155/2020/3413087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285392PMC

Microporous Frameworks as Promising Platforms for Antibacterial Strategies Against Oral Diseases.

Front Bioeng Biotechnol 2020 12;8:628. Epub 2020 Jun 12.

Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.

Nowadays, the heavy burden of oral diseases such as dental caries, periodontitis, endodontic infections, etc., and their consequences on the patients' quality of life indicate a strong need for developing effective therapies. Bacterial infections played an important role in the field of oral diseases, in-depth insight of such oral diseases have given rise to the demand for antibacterial therapeutic strategies. Read More

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http://dx.doi.org/10.3389/fbioe.2020.00628DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7304413PMC

Microbiology of molar-incisor hypomineralization lesions. A pilot study.

J Oral Microbiol 2020 20;12(1):1766166. Epub 2020 May 20.

Genomics and Health Department, FISABIO Institute, Valencia, Spain.

: An insufficient mineralization (hypomineralization) in the teeth during the maturation stage of amelogenesis cause defects in 3-44% of children. Here, we describe for the first time the microbiota associated with these defects and compared it to healthy teeth within the same subjects. : Supragingival dental plaque was sampled from healthy and affected teeth from 25 children with molar-incisor hypomineralization (MIH). Read More

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http://dx.doi.org/10.1080/20002297.2020.1766166DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7301705PMC

FACTORS CONTRIBUTING TO CHRONIC URTICARIA/ANGIOEDEMA AND NUMMULAR ECZEMA RESOLUTION - WHICH FINDINGS ARE CRUCIAL?

Acta Clin Croat 2019 Dec;58(4):595-603

1Department of Dermatovenereology, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia.

When working with dermatology patients, the question sometimes arises which diagnostic tests and tools should be used for workup, particularly in cases of chronic urticaria (CU) and discoid nummular eczema, where the treatment of associated systemic diseases and infections may be crucial for patient outcome. The aim was to investigate retrospectively the influence of associated diseases on skin disease outcomes based on medical records of CU and nummular eczema patients in comparison to controls. We included patients admitted to our Dermatology Department over a 6-year period and analyzed their laboratory findings, related factors and outcomes recorded after two years of workup and treatment. Read More

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http://dx.doi.org/10.20471/acc.2019.58.04.05DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314308PMC
December 2019

Mycoplasma pneumoniae-associated Stevens-Johnson syndrome: Characteristic histological features of mucosal lesion.

J Eur Acad Dermatol Venereol 2020 Jun 28. Epub 2020 Jun 28.

Division of Dermatology, Niigata University, Graduate School of Medicine and Dental Sciences.

Mycoplasma pneumoniae induces various skin conditions, potentially characterized by the development of extensive mucosal/eye lesions consistent with Stevens-Johnson syndrome (SJS). Particularly, in cases of pediatric SJS, M. pneumoniae infections are a major etiology. Read More

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http://dx.doi.org/10.1111/jdv.16796DOI Listing

Oral graft-versus-host disease: a pictorial review and a guide for dental practitioners.

Int Dent J 2020 Jun 28. Epub 2020 Jun 28.

Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem, Israel.

Introduction: Graft-versus-host disease (GVHD) is a complication of haematopoietic stem cell transplantation (HSCT). GVHD may also develop following solid transplants or blood transfusions if white blood cells are transferred. GVHD affects multiple organs, including the oral tissues. Read More

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http://dx.doi.org/10.1111/idj.12584DOI Listing

Antimicrobial and protective effects of non-thermal plasma treatments on the performance of a resinous liner.

Arch Oral Biol 2020 Jun 20;117:104822. Epub 2020 Jun 20.

Department of Prosthodontics and Periodontology, University of Campinas (UNICAMP), Piracicaba Dental School, Piracicaba, Brazil. Electronic address:

Objective: Overcoming substantial shortcomings of soft liners as physico-chemical changes and liner-biofilm-related infections remains a challenge in the rehabilitation treatment. In this study, protective non-thermal plasma (NTP) treatments were developed on the soft liner surface to improve its surface and physico-chemical properties and to reduce fungal colonization after biofilm inhibition challenge.

Methods: Resinous liner specimens (Coe-Soft) were prepared and distributed in 3 groups according to the surface treatments: (1) untreated (control); (2) treated with sulfur hexafluoride-based NTP (SF); and (3) treated with hexamethyldisiloxane-based NTP (HMDSO). Read More

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http://dx.doi.org/10.1016/j.archoralbio.2020.104822DOI Listing

Gasdermin D-independent release of interleukin-1b by living macrophages in response to mycoplasmal lipoproteins and lipopeptides.

Immunology 2020 Jun 26. Epub 2020 Jun 26.

Department of Oral Molecular Microbiology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Nishi 7, Kita 13, Kita-ku, Sapporo, Japan.

Interleukin-1b (IL-1b) plays pivotal roles in controlling bacterial infections and is produced after the processing of pro-IL-1b by caspase-1 which is activated by the inflammasome. In addition, caspase-1 cleaves the cytosolic protein, gasdermin-D (GSDMD), whose N-terminal fragment subsequently forms a pore in the plasma membrane, leading to the pyroptic cell death-mediated release of IL-1b. Living cells can also release IL-1b via GSDMD pores or other unconventional secretory pathways. Read More

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http://dx.doi.org/10.1111/imm.13230DOI Listing

Can orthodontic care be safely delivered during the COVID-19 pandemic? Recommendations from a literature review.

Authors:
Annabelle Carter

Evid Based Dent 2020 06;21(2):66-67

Leeds Dental Institute, Leeds, UK.

Data sources Five electronic databases were searched: COVID-19 Open Research Dataset (CORD-19-2020); PubMed; MEDLINE; Scopus; and Google Scholar.Study selection Titles of articles and abstracts were identified during the electronic database searches and then screened for relevance. Publications up until the date of the literature search, 19th March 2020, were used. Read More

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http://dx.doi.org/10.1038/s41432-020-0103-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317255PMC

Provision of dental hospital services during the COVID-19 epidemic.

Authors:
C Albert Yeung

Evid Based Dent 2020 06;21(2):63

Department of Public Health, NHS Lanarkshire, Kirklands, Fallside Road, Bothwell, G71 8BB, UK.

Data sources Information about health services provision of public tertiary dental hospitals in China mainland was retrieved through a web search engine. Data analysis The status of non-emergency dental services, emergency dental services and online professional consultation was recorded and analysed. If telehealth was provided, the charge,means of access, service time and service content were investigated. Read More

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http://dx.doi.org/10.1038/s41432-020-0096-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317252PMC

Saliva is a potential source of Covid-19, and appropriate protection measures should be applied in dental practice.

Authors:
Falk Schwendicke

Evid Based Dent 2020 06;21(2):62

Department of Oral Diagnostics, Digital Health and Health Services Research, Charité - Universitätsmedizin Berlin, Germany.

Data sources Non-systematically compiled data.Study selection No formal in- or exclusion criteria.Data extraction and synthesis Not described; narrative synthesis. Read More

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http://dx.doi.org/10.1038/s41432-020-0101-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317272PMC

Dentists thoughts about COVID-19.

Authors:
Asim Al-Ansari

Evid Based Dent 2020 06;21(2):60-61

Department of Preventive Dental Sciences, College of Dentistry, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Data sources Self-developed survey.Data extraction and synthesis This was a cross-sectional study using a self-administered online survey.Results Out of 700 randomly selected dentists in Jordan, 368 completed an online survey. Read More

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http://dx.doi.org/10.1038/s41432-020-0102-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317243PMC

Safety protocols for dental practices in the COVID-19 era.

Evid Based Dent 2020 06;21(2):56-57

Department of Periodontics and Oral Implantology, DAV (C) Dental College Yamunanagar, Haryana, India.

Aim Aim of this paper was to provide safety and operatory protocols for providing dental care during the COVID19 pandemic.Data sources The protocol is based on summarising the existing literature, published on different aspects of dealing with the pandemic situation. This protocol was established as an international collaboration among three dental universities: Hadassah School of Dental Medicine Israel, the University of Rochester Medical Centre USA, and the University of Pennsylvania USA. Read More

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http://dx.doi.org/10.1038/s41432-020-0094-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317251PMC

How can we reduce the risks of SARS-CoV-2 (COVID-19) for dentists and their patients?

Evid Based Dent 2020 06;21(2):50-51

Department of Endodontics, Dentistry School, Fluminense Federal University, Niterói, Rio de Janeiro, Brazil.

Design Special report.Study population This paper presented a report about the experience of the oral and maxillofacial surgeons (OMS) of Peking University School and Hospital of Stomatology, during the COVID-19 (SARS-CoV-2) pandemic.Data analysis The experience of that department formed the content of the report. Read More

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http://dx.doi.org/10.1038/s41432-020-0092-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317249PMC

Oral ulceration and blistering in patients with COVID-19.

Evid Based Dent 2020 06;21(2):49

Restorative Dentistry, Leeds Teaching Hospitals NHS Foundation Trust, UK.

Design Case series.Introduction The most common signs and symptoms of SARS-CoV-2 infection include headache, sore throat, hyposmia, hypogeusia, diarrhoea, dyspnoea and pneumonia. Dermatological manifestations have also been reported but few authors have documented oral signs and symptoms. Read More

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http://dx.doi.org/10.1038/s41432-020-0100-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317274PMC

How can dentistry get back to work safely?

Evid Based Dent 2020 06;21(2):48

VCU School of Dentistry, Lyons Building 415, 520 N. 12th Street, Richmond, VA, 23298, USA.

Data sources Narrative reviewStudy abstract This review provides a synopsis of our understanding of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its associated coronavirus disease, COVID-19. The virus is shed in the nasopharyngeal and salivary secretions of carriers, and this puts dental professionals at risk for increased exposure of SARS-CoV-2. The paper summarises the current guidelines outlined by the CDC and presents the triaging protocols to identify potential carriers and how to safely limit treatment to low-risk patients. Read More

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http://dx.doi.org/10.1038/s41432-020-0090-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317257PMC

The COVID-19 pandemic: implications for dental education.

Authors:
Chris Deery

Evid Based Dent 2020 Jun;21(2):46-47

Dean, Professor/Hon Consultant in Paediatric Dentistry, School of Clinical Dentistry, University of Dentistry, Claremont Crescent, Sheffield, S10 2TA, UK.

Aim This narrative review aims to report on the impacts of COVID-19 on the provision of dental education in the 67 dental schools in the United States (US). Having set the scene and current challenges, it aims to suggest some strategies to overcome the issues facing dental schools going forward.Background In the US the Occupational Safety and Health Administration classified dentists in the very high risk category because of the potential for exposure to the virus as a result of aerosol generating procedures (AGP). Read More

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http://dx.doi.org/10.1038/s41432-020-0089-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317244PMC

Coronavirus disease 2019 (COVID-19): challenges and management of aerosol-generating procedures in dentistry.

Evid Based Dent 2020 Jun;21(2):44-45

Oral Microbiologist, University of Health Sciences, Lahore, Pakistan.

Data sources Experimental investigation.Study design A retrospective review to evaluate the use of a negative-pressure otolaryngology viral isolation drape (NOVID) system to reduce cross-infection through aerosol. The apparatus consists of a plastic drape suspended over the surgical field in the head and neck region with a smoke evacuator suction placed inside the chamber with an ultra-low penetrating air (ULPA) efficiency rating and a fluid suction high-efficiency particulate air (HEPA) filter compartment. Read More

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http://dx.doi.org/10.1038/s41432-020-0088-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317264PMC

Can oral rinses play a role in preventing transmission of Covid 19 infection?

Evid Based Dent 2020 06;21(2):42-43

Senior Lecturer / Consultant in Restorative Dentistry, Centre for Public Health, Queen's University Belfast, UK.

This narrative review describes the existing body of evidence supporting the potential role of oral rinses in preventing the transmission of SARS-CoV2. Multiple sources were searched for evidence including PubMed, Researchgate and Google Scholar. References that were identified were then investigated further to find additional source material and the original primary research. Read More

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http://dx.doi.org/10.1038/s41432-020-0099-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7317247PMC

Mice Deficient in T-bet Form Inducible NO Synthase-Positive Granulomas That Fail to Constrain .

J Immunol 2020 Jun 26. Epub 2020 Jun 26.

Institute of Immunology and Immunotherapy, College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom;

Clearance of intracellular infections caused by Typhimurium (STm) requires IFN-γ and the Th1-associated transcription factor T-bet. Nevertheless, whereas IFN-γ mice succumb rapidly to STm infections, T-bet mice do not. In this study, we assess the anatomy of immune responses and the relationship with bacterial localization in the spleens and livers of STm-infected IFN-γ and T-bet mice. Read More

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http://dx.doi.org/10.4049/jimmunol.2000089DOI Listing

Antimicrobial susceptibility surveillance of bacterial isolates recovered in Japan from odontogenic infections in 2013.

J Infect Chemother 2020 Jun 23. Epub 2020 Jun 23.

Fukuoka Dental College, Fukuoka, Japan.

We report on the findings of the first antimicrobial susceptibility surveillance study in Japan of isolates recovered from odontogenic infections. Of the 38 facilities where patients representing the 4 groups of odontogenic infections were seen, 102 samples were collected from cases of periodontitis (group 1), 6 samples from pericoronitis (group 2), 84 samples from jaw inflammation (group 3) and 54 samples from phlegmon of the jaw bone area (group 4) for a total of 246 samples. The positivity rates of bacterial growth on culture were 85. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.05.019DOI Listing

Pharmacotherapy during Pregnancy: An Endodontic Perspective.

J Endod 2020 Jun 23. Epub 2020 Jun 23.

Department of Endodontics, Dental School, UT Health San Antonio. Electronic address:

Odontogenic pain affects up to 54.9% of pregnant women (1-3). This pain is often associated with pulpal and/or periapical infections which pose risks to women and their fetus. Read More

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http://dx.doi.org/10.1016/j.joen.2020.05.024DOI Listing

Periodontal condition and periodontal risk assessment in adult patients with cystic fibrosis.

Ann Agric Environ Med 2020 Jun 11;27(2):235-239. Epub 2019 Apr 11.

Department of Paediatric Dentistry, University of Medical Sciences, Poznań, Poland.

Introduction: The presence of chronic inflammation in the mouth, such as infectious disease of the periodontal tissues, may be the reservoir of microorganisms that are not usually present, including Pseudomonas aeruginosa.

Objective: The purpose of the study was to create a profile of periodontal conditions and periodontal risk assessment in adult patients with cystic fibrosis.

Material And Methods: The study involved 22 patients with cystic fibrosis (CF) aged 29. Read More

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http://dx.doi.org/10.26444/aaem/106087DOI Listing

A close look at the biology of SARS-CoV-2, and the potential influence of weather conditions and seasons on COVID-19 case spread.

Infect Dis Poverty 2020 Jun 26;9(1):77. Epub 2020 Jun 26.

Public Health Department, University of South Wales, Pontypridd, UK.

Background: There is sufficient epidemiological and biological evidence of increased human susceptibility to viral pathogens such as Middle East respiratory syndrome coronavirus, respiratory syncytial virus, human metapneumovirus and influenza virus, in cold weather. The pattern of outbreak of the coronavirus disease 2019 (COVID-19) in China during the flu season is further proof that meteorological conditions may potentially influence the susceptibility of human populations to coronaviruses, a situation that may become increasingly evident as the current global pandemic of COVID-19 unfolds.

Main Body: A very rapid spread and high mortality rates have characterized the COVID-19 pandemic in countries north of the equator where air temperatures have been seasonally low. Read More

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http://dx.doi.org/10.1186/s40249-020-00688-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7316581PMC

Antibiotics for Periodontal Infections: Biological and Clinical Perspectives.

J Contemp Dent Pract 2020 Apr 1;21(4):372-376. Epub 2020 Apr 1.

Department of Maxillofacial Surgery and Diagnostic Sciences, Division of Oral Pathology, College of Dentistry, Jazan University, Jazan, Kingdom of Saudi Arabia, Phone: +966 507633755, e-mail:

Aim: The review is to highlight the use of antibiotics in periodontal infections and prevent indiscriminate use of antibiotics.

Background: Periodontitis is the most common disease of the periodontal attachment apparatus, and its etiological factor can be related to the existence of virulent microorganisms in the dental plaque biofilm which harbors millions of microorganisms. In addition, the pathogenesis of this disease is greatly influenced by the host immune response that leads to the cyclic destruction and healing pattern. Read More

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Implant Treatment for a Patient With Large Condensing Osteitis: Case Report.

Authors:
Fawaz Alqahtani

J Oral Implantol 2020 Jun;46(3):249-252

Department of Prosthodontics, College of Dentistry, Prince Sattam bin Abdulaziz University, Al-kharj, Saudi Arabia.

Chronic endodontic infections are associated with osseous changes in the peri-apical regions. Dental implants are often placed after the extraction of hopeless teeth with periapical infections. This clinical report describes a patient with a radiopaque mass attached to the root apex of the mandibular right second premolar tooth (No. Read More

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http://dx.doi.org/10.1563/aaid-joi-D-19-00306DOI Listing

Precautions When Providing Dental Care During Coronavirus Disease 2019 (COVID-19) Pandemic.

Ann Acad Med Singapore 2020 May;49(5):312-319

Department of Oral and Maxillofacial Surgery, National Dental Centre, Singapore.

Transmission of coronavirus disease 2019 (COVID-19)-caused by novel severe acute respiratory syndrome coronavirus 2-through aerosolised saliva and respiratory droplets is possible when aerosol-generating dental procedures are performed. Consequently, dental practitioners are at increased risk of being infected when treating COVID-19 patients. A comprehensive review of the current literature on precautions when providing dental care during the COVID-19 pandemic is discussed and recommendations for dental practitioners are made. Read More

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Risk Assessment of Healthcare Workers at the Frontline against COVID-19.

Pak J Med Sci 2020 May;36(COVID19-S4):S99-S103

Prof. Fahim Vohra Department of Prosthetic Dental Science, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.

The novel coronavirus disease 2019 (COVID-19) is a global pandemic. Healthcare workers (HCWs) are on the frontline of treating patients infected with COVID-19. However, data related to its infection rate among HCWs are limited. Read More

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http://dx.doi.org/10.12669/pjms.36.COVID19-S4.2790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7306961PMC

Saliva-based PCR tests for SARS-CoV-2 detection.

J Oral Sci 2020 ;62(3):350-351

Oral and Maxillofacial Surgery, The Nippon Dental University Hospital.

The outbreak of novel coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide. Nasopharyngeal swabs are widely used in polymerase chain reaction (PCR) test to detect SARS-CoV-2. However, the collection of nasopharyngeal swabs has a series of drawbacks concerning exposure of healthcare staff, difficulty in collection, and discomfort of patients. Read More

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http://dx.doi.org/10.2334/josnusd.20-0267DOI Listing

Candida auris Phenotypic Heterogeneity Determines Pathogenicity .

mSphere 2020 Jun 24;5(3). Epub 2020 Jun 24.

Oral Sciences Research Group, Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

is an enigmatic yeast that provides substantial global risk in health care facilities and intensive care units. A unique phenotype exhibited by certain isolates of is their ability to form small clusters of cells known as aggregates, which have been to a limited extent described in the context of pathogenic traits. In this study, we screened several nonaggregative and aggregative isolates for biofilm formation, where we observed a level of heterogeneity among the different phenotypes. Read More

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http://dx.doi.org/10.1128/mSphere.00371-20DOI Listing