537,870 results match your criteria Dental Infections
Biol Trace Elem Res 2018 Dec 15. Epub 2018 Dec 15.
Pharmaceutical Chemistry, North Branch, Islamic Azad University, Tehran, Iran.
Many periodontal patients may need orthodontic treatment. Alterations in oral environment particularly the reduction of pH in periodontal patients could affect metal ion release from orthodontic appliances. However, there is no study on metal ion release in periodontal patients. Read More
J Neurooncol 2018 Dec 15. Epub 2018 Dec 15.
Department of Mechanical Engineering, University of Washington, Seattle, WA, 98195, USA.
Introduction: 5-ALA-based fluorescence-guided surgery has been shown to be a safe and effective method to improve intraoperative visualization and resection of malignant gliomas. However, it remains ineffective in guiding the resection of lower-grade, non-enhancing, and deep-seated tumors, mainly because these tumors do not produce detectable fluorescence with conventional visualization technologies, namely, wide-field (WF) surgical microscopy.
Methods: We describe some of the main factors that limit the sensitivity and accuracy of conventional WF surgical microscopy, and then provide a survey of commercial and research prototypes being developed to address these challenges, along with their principles, advantages and disadvantages, as well as the current status of clinical translation for each technology. Read More
Calcif Tissue Int 2018 Dec 15. Epub 2018 Dec 15.
Centre de référence des erreurs innées du métabolisme, Hôpital d'Enfants, CHRU Nancy, Nancy, France.
Osteoporosis is a common complication of cerebral palsy and Rett's syndrome. It is responsible for multiple fractures, bone pain, and impaired quality of life. In case of Rett's syndrome, a specific dysfunction of osteoblasts causes bone fragility. Read More
Clin Oral Investig 2018 Dec 15. Epub 2018 Dec 15.
Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.
Objectives: Saliva is a bodily fluid transuded from gingival crevice fluid and blood and contains many proteins. Proteins in saliva have been studied as markers for periodontal diseases. Mass spectrometric analysis is applied to investigate biomarker proteins that are related to periodontitis. Read More
Eat Weight Disord 2018 Dec 15. Epub 2018 Dec 15.
Dietetics and Clinical Nutrition Laboratory, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy.
Purpose: Oxidized LDL cholesterol (oxLDL) has been considered as a sensor of oxidative stress (OS) in childhood obesity. We integrated and related our oxLDL existing results previously assessed in overweight/obese children to lifestyle variables to investigate OS-related lifestyle variables.
Methods: 178 Caucasian children/adolescents have been evaluated and according to BMI percentiles have been classified as normal weight (BMI < 75th); overweight (BMI 75-97th) and obese (BMI > 97th). Read More
Support Care Cancer 2018 Dec 15. Epub 2018 Dec 15.
Department of Palliative Medicine, Osaka City General Hospital, 2-13-22 Miyakojima-hondori, Miyakojima-ku, Osaka City, Osaka, 534-0021, Japan.
Purpose: Few studies have investigated nutrition impact symptoms and eating-related distress among advanced cancer patients and their families. This is a questionnaire survey to examine the severity of nutrition impact symptoms and the prevalence of eating-related distress among them in palliative and supportive care settings.
Methods: Questionnaires for patients and their families were preliminarily developed. Read More
Fetal Diagn Ther 2018 Dec 14:1-10. Epub 2018 Dec 14.
Fetal Medicine Centre, Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom.
Background/purpose: We report a case study of jejunal atresia and the results of a systematic literature review of all reported cases of bowel complications occurring after fetoscopic laser ablation (FLA) for the treatment of twin-to-twin transfusion syndrome (TTTS).
Methods: A systematic literature review was performed of bowel complications after FLA for TTTS according to PRISMA guidelines.
Results: There are 11 published cases of small bowel atresia, 5 cases of necrotising enterocolitis (NEC), and 2 cases with foetal bowel perforations. Read More
Neurosci Lett 2018 Dec 13. Epub 2018 Dec 13.
Department of Pharmacology, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Division of Oral and Craniomaxillofacial Research, Dental Research Center, Nihon University School of Dentistry, 1-8-13 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-8310, Japan; Molecular Dynamics Imaging Unit, RIKEN Center for Life Science Technologies, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe, Hyogo 650-0047, Japan.
Temperature plays a critical role in the sensation of airflow in the nasal mucosa. Neural activities of the ethmoidal nerve, a trigeminal afferent, responding to airflow are suppressed by warm airflow, whereas cold airflow enhances the ethmoidal nerve activities, which is mimicked by application of menthol, a cold-sensitive TRPM8 receptor agonist. However, it has been an open issue how menthol modulates the spatiotemporal profiles of neural activities of somatosensory cortical neurons. Read More
J Pharm Sci 2018 Dec 13. Epub 2018 Dec 13.
Department of Physiological Sciences, Piracicaba Dental School, University of Campinas, Piracicaba, São Paulo, Brazil. Electronic address:
The use of permeation enhancers such as microneedles (MNs) to increase drug penetration across intraoral mucosa has increased in recent years. Permeation studies, commonly performed using vertical diffusion cells, are a well-established way to preview formulations and enhance their performance during the development stage. However, to our knowledge, the existing intraoral mucosa barrier models do not permit permeation using MNs-pretreated mucosa, due to their insufficient thickness. Read More
Med Eng Phys 2018 Dec 13. Epub 2018 Dec 13.
Department of Anatomy, College of Medical and Dental Sciences, University of Birmingham, United Kingdom. Electronic address:
Cubital tunnel syndrome is the most prevalent neuropathy of the ulnar nerve and its aetiology is controversial. Potential replacement materials should display similar viscoelastic properties. The purpose of this study was to assess the feasibility and merit of quantifying the frequency-dependent viscoelastic properties of proximal and distal sections of the human ulnar nerve. Read More
Biochem Biophys Res Commun 2018 Dec 12. Epub 2018 Dec 12.
Academy of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou, 510630, China. Electronic address:
Osteoclasts play an important role in bone remodeling. The inflammatory cytokine IL-17A could modulate the RANKL-induced osteoclastogenesis by regulating the autophagic activity. It is well accepted that protective autophagy has an anti-apoptotic effect. Read More
J Mech Behav Biomed Mater 2018 Dec 6;91:109-121. Epub 2018 Dec 6.
University of Granada, Faculty of Dentistry, Dental Materials Section, Colegio Máximo de Cartuja s/n, 18071 Granada, Spain.
The aim of this research was to ascertain the mechanical and chemical behavior of sound and caries-affected dentin (CAD), after the placement of Zn-free vs containing amalgam restorations. Peritubular and intertubular dentin were evaluated using, a) nanoindenter in scanning mode; the load and displacement responses were used to perform the nano-Dynamic mechanical analysis and to estimate the complex (E * ) and storage modulus (E'); b) Raman spectroscopy was used to describe the hierarchical cluster analysis (HCA). Assessments were performed before restoration placement and after restoring, and after 3 months of storage with thermocycling (100,000cy/5 °C and 55 °C). Read More
J Crit Care 2018 Dec 1;50:177-187. Epub 2018 Dec 1.
University of Ottawa, Faculty of Health Sciences, School of Nursing, 3245B Roger Guindon Hall, 451 Smyth Road, Ottawa, ON K1H 8M5, Canada. Electronic address:
Purpose: Despite advances in medical science, patient death and family bereavement are commonly encountered in adult intensive care units (ICUs). This is the first review to investigate the state of ICU bereavement support globally, and the availability and effectiveness of bereavement support interventions.
Methods: A systematic review and narrative synthesis. Read More
Genomics 2018 Dec 12. Epub 2018 Dec 12.
Genetics Program, Instituto Nacional de Câncer (INCA), Rio de Janeiro, Brazil. Electronic address:
Scarce data are available on the expression of Papillomavirus genome and the frequency of alternatively spliced E6/E7 mRNAs in invasive cervical cancer. We carried out a comprehensive characterization of HPV expression by RNA-Seq analysis in 22 invasive cervical cancer with HPV16 or HPV18, characterizing the presence of integrated/episomal viral DNA, the integration sites in human genome and the proportion of alternative splicing products of E6 and E7 genes. The expression patterns suggested the presence of episomal and/or integrated viral DNA, with integration detected in most tumors, frequently occurring within human genes in HPV18+ and in intergenic regions in HPV16+ tumors. Read More
J Dent 2018 Dec 12. Epub 2018 Dec 12.
Department of Advanced Oral Sciences and Therapeutics, University of Maryland School of Dentistry, Baltimore, MD 21201, USA; Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:
Objectives: The objectives of this study were to: (1) develop a novel multifunctional composite with nanoparticles of silver (NAg), 2-methacryloyloxyethyl phosphorylcholine (MPC), dimethylaminohexadecyl methacrylate (DMAHDM) and nanoparticles of amorphous calcium phosphate (NACP); and (2) investigate biofilm-inhibition via the multifunctional nanocomposite against three species of periodontal pathogens for the first time.
Methods: The multifunctional nanocomposite was fabricated by incorporating NAg, MPC, DMAHDM and NACP into the resin consisting of pyromellitic glycerol dimethacrylate (PMDGDM) and ethoxylated bisphenol A dimethacrylate (EBPADMA). Three species (Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans and Fusobacterium nucleatum) were tested for metabolic activity (MTT), live/dead staining, polysaccharide production and colony-forming units (CFU) of biofilms grown on resins. Read More
Am J Ophthalmol 2018 Dec 12. Epub 2018 Dec 12.
Department of Ophthalmology, Tokyo Dental Collage Suidobashi Hospital.
Purpose: To evaluate the binocular visual function and depth of focus after staged implantation of diffractive multifocal intraocular lenses (MIOLs) with three different add powers following cataract removal.
Design: Prospective comparative case series.
Methods: Setting: Institutional. Read More
Head Neck 2018 Dec 15. Epub 2018 Dec 15.
Department of Oral and Maxillofacial Surgery and Special Dental Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: Chewing ability is often compromised in patients with oral cancer. The aim of this study was to identify which factors affect masticatory performance in these patients.
Methods: Patients with primary oral cancer were assessed for up to 5 years after primary treatment. Read More
Eur Arch Paediatr Dent 2018 Dec 14. Epub 2018 Dec 14.
Faculty of Dental Surgery, University of Malta, Msida, Malta.
Aim: To determine the influence of erosive tooth wear in the primary dentition on parental perceptions of oral health.
Methods: This cross-sectional study involved a standardised clinical examination of 775 preschool aged children and a parent-administered questionnaire. Erosive tooth wear was measured using the Basic Erosive Wear Examination Index. Read More
Ir J Med Sci 2018 Dec 14. Epub 2018 Dec 14.
Department of Anaesthesia, The Rotunda Hospital, Parnell Square, Dublin, Ireland.
Background: Rigid bronchoscopy may be used to relieve acute airway obstruction following induction of anaesthesia and is a recommended option for management of the difficult airway. The ability of anaesthetists to perform rigid bronchoscopy has not been reported. We sought to explore the acquisition of procedural skill in rigid bronchoscopy by anaesthesiologists in a manikin. Read More
Clin Oral Investig 2018 Dec 14. Epub 2018 Dec 14.
Department of Physiology and Pathology, Araraquara School of Dentistry, São Paulo State University (Unesp), Rua Humaitá, 1680, Araraquara, SP, 14801-903, Brazil.
Objectives: To assess the biological, antimicrobial, and mechanical effects of the treatment of deep dentin with simvastatin (SV) before application of a glass-ionomer cement (GIC).
Materials And Methods: Dentin discs were adapted to artificial pulp chambers and SV (2.5 or 1. Read More
Clin Oral Investig 2018 Dec 14. Epub 2018 Dec 14.
Department of Pediatric dentistry, Goa Dental College, Goa, Bambolim, India.
Aim: The aim of this study was to compare the effectiveness of 2% articaine and 2% lignocaine in achieving adequate anesthesia in children between the age group of 6-13 years using inferior alveolar nerve block.
Methods: A triple blinded randomized controlled trial was conducted in 180 participants (90 patients- 2% articaine, 90 patients-2% lignocaine). Effectiveness of the anesthetic agent was determined at 3 points determined by subjective evaluation of pain using pain scales (FPS-R). Read More
Surg Radiol Anat 2018 Dec 14. Epub 2018 Dec 14.
Department of Oral Biology, University of Pittsburgh, 412 Salk Pavilion, Pittsburgh, PA, 15261, USA.
The aim of this study was to investigate the association between condylar bone morphological characteristics with occlusal conditions. Besides the study will compare the tomography images with the real condition in 122 temporomandibular joints from 61 skulls. The occlusal conditions were evaluated by number of teeth missing, measurement of overjet and overbite, in millimeters, and presence or absence of crossbite, openbite and dental rotation. Read More
Br Dent J 2018 Dec 14. Epub 2018 Dec 14.
The patient-dentist relationship is a delicate partnership that forms the core of dentistry. The attack on this partnership by the General Dental Council has led to gross miscarriages of justice and the emergence of defensive dentistry. This essay considers the role of a governing body, the misconduct of the GDC and the response of the profession to the injustices perpetrated. Read More
BMJ Open 2018 Dec 14;8(12):e022952. Epub 2018 Dec 14.
Department of Dentistry, School of Health Sciences, University of Brasília, Brasilia, Brazil.
Introduction: Selective (incomplete/partial) carious tissue removal is suitable for treating deep carious lesions in teeth with vital, asymptomatic pulps. In the periphery of a cavity, removal to hard dentin is performed, while in pulpo-proximal areas, leathery or soft dentin is left to avoid pulp exposure. As the decision of what contains 'soft' or 'leathery' dentin is subjective, using self-limiting burs which help to standardise the hardness of the remaining dentin, has been suggested to increase the reliability of carious tissue removal. Read More
Appl Environ Microbiol 2018 Dec 14. Epub 2018 Dec 14.
Department of Oral Biology, College of Dentistry, University of Florida, Gainesville, Florida, USA
The asaccharolytic anaerobe metabolizes proteins it encounters in the periodontal pocket, including host-derived glycoproteins such as mucins and immunoglobulins. Often, these proteins are protected by a diverse array of carbohydrates tethered to the polypeptide chain via glycolytic bonds, and produces enzymes capable of liberating these carbohydrates, exposing the proteinaceous core. In this study, we investigated the effect of individual monosaccharides, including galactose, L-fucose, mannose and glucose, on the growth and physiology of Of the carbohydrates tested, only galactose noticeably altered the density of the bacterial culture, and we observed that cultures grown with galactose reached significantly higher densities during stationary phase. Read More
Respir Investig 2018 Dec 11. Epub 2018 Dec 11.
Department of Respiratory Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan. Electronic address:
Background: Cigarette smoking in patients with asthma leads to poor symptom control. As patients who are current smokers have been excluded from enrollment in many clinical trials on asthma, there are few reports on the treatment in current smokers with asthma. In this study, we aimed to assess how respiratory physicians manage asthma in current smokers in Japan. Read More
Immunity 2018 Dec 5. Epub 2018 Dec 5.
Jill Roberts Institute for Research in IBD, Weill Cornell Medicine, New York, NY, 10021, USA; Jill Roberts Center for IBD, Weill Cornell Medicine, New York, NY, 10021, USA. Electronic address:
Inflammatory bowel disease (IBD) results from a dysregulated interaction between the microbiota and a genetically susceptible host. Genetic studies have linked TNFSF15 polymorphisms and its protein TNF-like ligand 1A (TL1A) with IBD, but the functional role of TL1A is not known. Here, we found that adherent IBD-associated microbiota induced TL1A release from CX3CR1 mononuclear phagocytes (MNPs). Read More
J Pharmacol Sci 2018 Dec 1. Epub 2018 Dec 1.
Department of Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
We recently developed PA-8, a novel small-molecule antagonist of PACAP type 1 (PAC1) receptor. In the present study, we examined whether PA-8 was effective against formalin-induced inflammatory pain in mice. Both intrathecal and oral administration of PA-8 resulted in the dose-dependent attenuation of the second phase of formalin-induced nociceptive responses. Read More
Bioorg Med Chem Lett 2018 Dec 4. Epub 2018 Dec 4.
Department of Life Science and Technology, Tokyo Institute of Technology, 4259 J2-16, Nagatsuta-cho, Midori-ku, Yokohama, Kanagawa 226-8501, Japan. Electronic address:
The effect of 2'-O-(N-methylcarbamoyl)ethyl (MCE) modification on splice-switching oligonucleotides (SSO) was systematically evaluated. The incorporation of five MCE nucleotides at the 5'-termini of SSOs effectively improved the splice switching effect. In addition, the incorporation of 2'-O-(N-methylcarbamoylethyl)-5-methyl-2-thiouridine (sT), a duplex-stabilizing nucleotide with an MCE modification, into SSOs further improved splice switching. Read More
Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Nov 22;126(5):409-414. Epub 2018 Aug 22.
Professor and Head, Oral Medicine, Department of Oral Health and Diagnostic Sciences, School of Dental Medicine; Co-chair, Head & Neck Cancer/Oral Oncology Program, Neag Comprehensive Cancer Center, UConn Health Farmington, CT, USA.
There have been strategic clinical, educational, and research advances in the field of Oral Medicine over the past several decades. In many cases, Oral Medicine experts are contributing the lead role in these advances nationally and internationally. In addition, American Board of Dental Specialty recognition of Oral Medicine as a specialty in 2015 has positioned Oral Medicine professionals to substantively enhance the delivery of oral health care to medically complex patients as well. Read More
Dent Mater 2018 Dec 11. Epub 2018 Dec 11.
HEPIA, University of Applied Sciences - Western Switzerland (HES-SO), Geneva, Switzerland. Electronic address:
Objectives: To provide fractographic analysis of clinically fractured zirconia implants recovered with their cemented crown. To calculate bending moments, corresponding stress and crack onset location on the implant's fracture surface using a mathematical model integrating spatial coordinates of the crown-implant part and occlusal loading obtained from 2D and 3D images.
Methods: 15 fractured zirconia implants parts (11 posterior and 4 anterior) with their all- ceramic crowns still cemented on it were recovered. Read More
Arch Iran Med 2018 Nov 1;21(11):551-555. Epub 2018 Nov 1.
Academy of Medical Sciences Islamic Republic of Iran, Tehran, Iran.
This is a brief look at the establishment and development of oral and maxillofacial pathology in Iran. The program of the oral and maxillofacial pathology at first was integrated into the curriculum of the Dental School of Tehran University in 1960. The Iranian Society of Oral and Maxillofacial Pathologists was officially founded in 1999. Read More
Genes (Basel) 2018 Dec 13;9(12). Epub 2018 Dec 13.
Institute of Mobilome and Genome, College of Animal Science & Technology, Yangzhou University, Yangzhou 225009, China.
Although transposon-mediated enhancer trapping (ET) is successfully applied in diverse models, the efficiency of various transposon systems varies significantly, and little information is available regarding efficiency of enhancer trapping by various transposons in zebrafish. Most potential enhancers (Ens) still lack evidence of actual En activity. Here, we compared the differences in ET efficiency between (), () and transposons. Read More
Int J Mol Sci 2018 Dec 13;19(12). Epub 2018 Dec 13.
Department of Cranio-Maxillofacial Surgery, Research Unit Vascular Biology of Oral Structures (VABOS), University Hospital Muenster, 48149 Muenster, Germany.
For the guided regeneration of periimplant hard and soft tissues, human adipose-derived stromal cells (hADSC) seem to be a promising source for mesenchymal stromal cells. For this, the proliferation and differentiation of hADSC were evaluated on titanium and zirconia dental implants with different surface treatments. Results were compared to edaphic cells as human osteoblasts (hOB) and human gingival fibroblasts (HGF). Read More
Diagnostics (Basel) 2018 Dec 13;8(4). Epub 2018 Dec 13.
Department of Medical Sciences, Clinical Microbiology, Uppsala University, Dag Hammarskjölds väg 38, 75237 Uppsala, Sweden.
Campylobacters are major enteropathogens worldwide with a substantial financial burden. Matrix metalloproteinases (MMPs) are proteolytic metalloendopeptidases with ability to modify immune response and shown to be upregulated in patients with several tissue destructive diseases, including infections. We measured here serum concentrations of MMP-8 and MMP-9 together with their regulators myeloperoxidase (MPO), human neutrophil elastase (HNE), and tissue inhibitor of metalloproteinases (TIMP)-1 in 80 and 25 patients as well as in 27 healthy controls. Read More
Dent J (Basel) 2018 Dec 13;6(4). Epub 2018 Dec 13.
Tecnologica Research Institute, Stem Cells Unit, 88900 Crotone, Italy.
Tissue engineering is based on the interaction between stem cells, biomaterials and factors delivered in biological niches. Oral tissues have been found to be rich in stem cells from different sources: Stem cells from oral cavity are easily harvestable and have shown a great plasticity towards the main lineages, specifically towards bone tissues. Dental pulp stem cells (DPSCs) are the most investigated mesenchymal stem cells (MSCs) from dental tissues, however, the oral cavity hosts several other stem cell lineages that have also been reported to be a good alternative in bone tissue engineering. Read More
Biomed Pharmacother 2019 Jan 26;109:1924-1931. Epub 2018 Nov 26.
Trauma Research Center, Aja University of Medical Science, Tehran, Iran. Electronic address:
The purpose of this study was to investigate the effects of Fibrin Glue (FG) and activated platelet-rich plasma (a-PRP) on the proliferation and osteogenic differentiation of human dental pulp stem cells (h-DPSCs). Therefore, we planned to investigate in vitro behavior of porous composite scaffolds based on chitosan-gelatin/nanohydroxyapatite (CS-G/nHA) treated with FG and a-PRP. The porous structure of CS-G/nHA was prepared using combination of particle leaching and freeze-drying methods. Read More
Biomed Pharmacother 2019 Jan 20;109:1709-1717. Epub 2018 Nov 20.
Department of Oral and Maxillofacial Surgery, The First Affiliated Hospital, Sun Yat-sen University & Guangdong Key Laboratory of Stomatology, Guangdong, China. Electronic address:
Background: Circular RNAs (circRNAs) comprise a novel class of noncoding RNAs that play important roles in a variety of diseases. However, the mechanism by which circRNAs regulate the osteogenic differentiation of maxillary sinus membrane stem cells (MSMSCs) remains largely unclear.
Methods: Microarray analysis was used to explore the expression profiles of circRNAs during the osteogenic differentiation of normal and BMP2 induced-MSMSCs. Read More
Biomed Pharmacother 2019 Jan 9;109:1259-1267. Epub 2018 Nov 9.
Department of Dental Implant, Stomatological Hospital of Chongqing Medical University, Chongqing, 400015, China. Electronic address:
Implant bone defects are the most common phenomenon in the processes of bone transplantation. Evidences have identified that fibroblast growth factor-21 (FGF-21) encourages osteogenesis for patients with implant bone defects. The purpose of this study was to investigate the role of FGF-21 and its potential mechanism in bone mesenchymal stem cells (BMSCs). Read More
Biomed Pharmacother 2019 Jan 6;109:1126-1139. Epub 2018 Nov 6.
Dental School of São Paulo State University, Department of Morphology, Araraquara, Brazil. Electronic address:
The selective serotonin reuptake inhibitor fluoxetine has been used for the treatment of depression. Although sexual disorders have been reported in male patients, few studies have demonstrated the fluoxetine effect on the reproductive histophysiology, and the target of this antidepressant in testes is unknown. We evaluated the impact of short-term treatment with fluoxetine on the adult rat testes, focusing on steroidogenesis by Leydig cells (LC) and androgen-dependent testicular parameters, including Sertoli cells (SC) and peritubular myoid cells (PMC). Read More
Psychiatry Res 2018 Dec 30;270:940-946. Epub 2018 Oct 30.
Department of Molecular Neurobiology, Brain Research Institute, Niigata University, 1-757, Asahimachi-dori, Chuo-ku Niigata, Niigata 951-8585, Japan. Electronic address:
Perineuronal nets comprise chondroitin sulfate moieties and their core proteins, and their neuropathological alterations have been implicated in schizophrenia. To explore the molecular mechanism of the perineuronal net impairments in schizophrenia, we measured the immunoreactivity of chondroitin sulfate moieties, major components of perineuronal nets, in three brain regions (postmortem dorsolateral prefrontal cortex, caudate nucleus, and hippocampus) of schizophrenia patients and control subjects. Immunoblotting for chondroitin 4-sulfate and chondroitin 6-sulfate moieties revealed a significant increase in intensity of a 180 kD band of chondroitin 4-sulfate immunoreactivity in the hippocampus of patients, although we detected no significant alteration in their immunoreactivities with any other molecular sizes or in other brain regions. Read More
J Gastroenterol Hepatol 2018 Dec 14. Epub 2018 Dec 14.
Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University, Tokyo, Japan.
Background And Aim: The treat-to-target strategy has emerged in ulcerative colitis management. Mucosal healing is the best target, albeit not in induction therapy of acute diseases as clinical conditions vary over a short duration. To determine the targets during induction therapy for acute ulcerative colitis, we identified markers to predict mucosal healing at 3 and 12 months of initiating the induction therapy. Read More
J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.
Section of Population Oral Health, Columbia University College of Dental Medicine, New York, NY, USA.
Objectives: To identify and characterize US early childhood caries (ECC) programs.
Methods: A 39 question online survey was fielded to 245 ECC programs identified from the literature and peer programs. The 101 respondents (41 percent response rate) reported their program's geographic reach, type, areas of focus, target populations, approaches, affiliations, providers, goals, costs, and funding. Read More
J Public Health Dent 2018 Dec 14. Epub 2018 Dec 14.
Menzies Health Institute Queensland, Griffith University, Gold Coast, Queensland, Australia.
Objectives: This study explored the association of children's salivary characteristics, past caries experience, birth weight, and reported maternal prenatal vitamin and mineral supplementation with the dental untreated decay of the child.
Methods: This cross-sectional study, a sub-study of Griffith University Environments for Healthy Living birth cohort study, was conducted on 174 mother-child dyads. Mother's prenatal usage of vitamin and mineral supplements; child's birthweight; salivary pH, buffering capacity, and levels of salivary MS and LB were explored as risk indicators. Read More
Cell 2018 Dec;175(7):1756-1768.e17
Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Cell Biology, Harvard University Medical School, Boston, MA 02115, USA. Electronic address:
Irisin is secreted by muscle, increases with exercise, and mediates certain favorable effects of physical activity. In particular, irisin has been shown to have beneficial effects in adipose tissues, brain, and bone. However, the skeletal response to exercise is less clear, and the receptor for irisin has not been identified. Read More
PLoS One 2018 14;13(12):e0208886. Epub 2018 Dec 14.
Dental Research Centers, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran.
Objective: Gingivitis and poor oral hygiene status are the most prevalent oral diseases among primary school students. Poor oral hygiene status, gingivitis and socio-demographic determinants have been shown to be associated with periodontal diseases. There is limited information on the gingivitis and oral hygiene status among Iranian children. Read More
J Craniofac Surg 2018 Dec 13. Epub 2018 Dec 13.
Dental/Medical Center of Maxillofacial Surgery "Aleja-Centar," Banja Luka, Bosnia and Herzegovina.
Septoplasty is usually performed under general anesthesia or local anesthesia with sedation. Nevertheless, septoplasty under pure local anesthesia is also feasible and it shows a great potential for fast-track surgery. This article presents a patient with nasal septal deviation where septoplasty was managed under local anesthesia at an outpatient clinic. Read More
Anesthesiology 2019 Jan;130(1):91
J Med Econ 2018 Dec 14:1-28. Epub 2018 Dec 14.
e Market Access, Health Economics and Outcomes Research , Bayer Yakuhin, Ltd , Tokyo , Japan.
Aims: To estimate the impact of anti-vascular endothelial growth factor (VEGF) agents on visual impairment and blindness avoided in patients with diabetic macular edema (DME) and on associated patient and caregiver productivity loss in Japan.
Methods: We compared the impact of current care (estimated at 53.8% utilization of anti-VEGF agents using current data) with that of hypothetical care (characterized by a higher utilization of anti-VEGF agents [80. Read More
G Ital Nefrol 2018 Dec;35(6)
Department of Oral Surgery, Faculty of Dental medicine, Medical University, Plovdiv, Bulgaria.
Introduction: End-stage chronic kidney disease (CKD) is characterized by kidney failure with the organ's functions reduced or lost completely, where the kidneys are incapable of filtering excess fluids. Renal replacement therapy may be provided by peritoneal dialysis, hemodialysis or renal transplantation. Among the key indicators for tracking patients' current status are urea and creatinine levels. Read More