537,599 results match your criteria Dental Fractured Tooth


Influence of Nutritional Management and Rehabilitation on Physical Outcome in Japanese Intensive Care Unit Patients: A Multicenter Observational Study.

Ann Nutr Metab 2018 Dec 12;74(1):35-43. Epub 2018 Dec 12.

Emergency and Critical Care Medicine, Tokushima University Graduate School, Tokushima, Japan.

Background: There is lack of evidence regarding nutritional management among intensive care unit (ICU) patients in a population with relatively low body mass index. Therefore, we conducted an observational study to assess the nutritional management in Japanese ICUs. Also, we investigated the impact of nutritional management and rehabilitation on physical outcome. Read More

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December 2018

Re-exposure in cone beam computed tomography of the dentomaxillofacial region: a retrospective study.

Dentomaxillofac Radiol 2018 Dec 12:20180184. Epub 2018 Dec 12.

1 Department of Oral and Maxillofacial Surgery, Plastic Surgery, University Medical Center of the Johannes Gutenberg-University Mainz , Mainz , Germany.

Objective:: CBCT often use a smaller field of view compared to conventional CT scans. This might lead to a wrong field of view with the need for secondary exposure ("retakes"). The purpose of this retrospective study was to assess the frequency of re-exposures in cone beam computed tomography (CBCT) and to identify whether the parameters age, gender and FOV have an influence on the re-exposure of the patient. Read More

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December 2018

Are metal artefact reduction algorithms effective to correct cone beam CT artefacts arising from the exomass?

Dentomaxillofac Radiol 2018 Dec 12:20180290. Epub 2018 Dec 12.

1 Department of Oral Diagnosis, Division of Oral Radiology, Piracicaba Dental School, University of Campinas , Piracicaba , Brazil.

The aim of this study was to evaluate the effectiveness of metal artefact reduction (MAR) in cone beam computed tomography (CBCT) artefacts arising from metallic objects in the exomass. A radiographic phantom composed of 16 polypropylene tubes filled with a homogeneous radiopaque solution was created. CBCT scans were obtained with two units: Picasso Trio (Vatech, South Korea) and ProMax (Planmeca, Finland). Read More

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December 2018

Can a high-density dental material affect the automatic exposure compensation of digital radiographic images?

Dentomaxillofac Radiol 2018 Dec 12:20180331. Epub 2018 Dec 12.

1 Department of Oral Diagnosis, Division of Oral Radiology,, Piracicaba Dental School, University of Campinas (UNICAMP) , Sao Paulo , Brazil.

Objective:: To investigate the influence of high-density dental material on the automatic exposure compensation (AEC) of digital radiographic imaging systems.

Methods:: Two radiographic phantoms were custom made to reproduce radiographic densities of the dental tissues: enamel, dentin and pulp chamber. The phantoms were X-rayed using the Digora Toto, Digora Optime and VistaScan systems for 0. Read More

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December 2018

Mediterranean herb extracts inhibit microbial growth of representative oral microorganisms and biofilm formation of Streptococcus mutans.

PLoS One 2018 12;13(12):e0207574. Epub 2018 Dec 12.

Department of Operative Dentistry and Periodontology, Medical Center, University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

In light of the growing antibiotic resistance, the usage of plant-derived antimicrobial agents could serve as an effective alternative treatment against oral infections. The aim of this study was to investigate the antimicrobial and antibiofilm activity of Mediterranean herb extracts against representative oral microorganisms. The extraction procedures and the analysis of the obtained extracts were performed under established experimental conditions. Read More

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December 2018

Risk Factors for Pancreatic Stone Formation in Type 1 Autoimmune Pancreatitis: A Long-term Japanese Multicenter Analysis of 624 Patients.

Pancreas 2019 Jan;48(1):49-54

Department of Gastroenterology and Hepatology, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Objective: Autoimmune pancreatitis (AIP) has the potential to transform into chronic pancreatitis with pancreatic stone involvement. This retrospective investigation sought to clarify the risk factors for stone formation in type 1 AIP.

Methods: Questionnaires on patients with type 1 AIP were sent to 22 high-volume medical centers across Japan to compare the clinical features of patients with and without pancreatic stone formation. Read More

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January 2019

Is anterior guidance a key factor on planning implant treatment for free-end missing in the posterior mandible?

J Oral Implantol 2018 Dec 12. Epub 2018 Dec 12.

1 Kyushu Dental University Department of Oral Reconstruction and Rehabilitation Kyushu Dental University.

To perform safe implant treatment, the anatomical structure and bone quality at implant placement sites are evaluated based on a patient's CT data, but there is no definite method to determine placement sites and the appropriate number of implants. The objective of this study was to investigate the influence of the number and arrangement of implants on the stress distribution in 3-unit posterior fixed partial dentures for the posterior mandible by mechanical analysis using the finite element method. Three-dimensional finite element analysis models were constructed from the CT data of a patient with missing mandibular teeth (Nos. Read More

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December 2018

Parallelism of Dental Implants.

Authors:
Dennis Flanagan

J Oral Implantol 2018 Dec 12. Epub 2018 Dec 12.

1 Connecticut Dental Groups Pres n/a Connecticut Dental Groups.

Parallelism in dental implant positioning may not be detrimental. Read More

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December 2018

Cdc42 negatively regulates endocytosis during apical membrane maintenance in live animals.

Mol Biol Cell 2018 Dec 12:mbcE18100615. Epub 2018 Dec 12.

Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Dr. Rm 2050B, Bethesda, MD, 20892 USA.

Lumen establishment and maintenance are fundamental for tubular organs physiological functions. Most of the studies investigating the mechanisms regulating this process have been carried out in cell cultures or in smaller organisms, whereas little has been done in mammalian model systems in vivo. Here we used the salivary glands of live mice to examine the role of the small GTPase Cdc42 in the regulation of the homeostasis of the intercellular canaliculi, a specialized apical domain of the acinar cells, where protein and fluid secretion occur. Read More

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December 2018

TRANSLATION, CROSS-CULTURAL ADAPTATION AND PRELIMINARY EVALUATION OF THE BRAZILIAN VERSIONOF THE PAIN CATASTROPHIZING SCALE-PARENTS.

Rev Paul Pediatr 2018 Oct-Dec;36(4):428-436

Universidade Federal de Goiás, Goiânia, GO, Brasil.

Objective: In Brazil, there is no scale to assess parental catastrophizing about their child's pain. This study aimed to translate and cross-culturally adapt the Pain Catastrophizing Scale-Parents to the Brazilian Portuguese language, as well as to preliminarily evaluate its psychometric properties among parents/guardians of children with and without a toothache.

Methods: A cross-sectional study was conducted with 237 parents/other relatives of 237 children. Read More

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Effect of diode laser irradiation on the bond strength of polymerized non-simplified adhesive systems after 12 months of water storage.

J Appl Oral Sci 2018 Dec 10;27:e20180126. Epub 2018 Dec 10.

Universidade de São Paulo, Faculdade de Odontologia de Bauru, Departamento de Dentística, Endodontia e Materiais Odontológicos, Bauru, São Paulo, Brasil.

Objectives: The aim of this in vitro study was to evaluate the bonding strength of non-simplified dentin bonding systems (DBS) to dentin irradiated with a diode laser (970 nm) immediately and after 12 months of water storage following either primer or bond application.

Material And Methods: The experimental design included three different factors: DBS type [AdperTM Scotchbond Multipurpose (MP) and Clearfil™ SE Bond (CSE)], irradiation [without irradiation - control (C), irradiation after primer application (AP), and irradiation after bond application (AB)], and time [initial (I) and after 12 months of water storage (12 m)]. Sixty sound human third molars (n = 10) were obtained, and their flat occlusal dentin areas were prepared and standardized. Read More

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December 2018

Effect of fluoride application during radiotherapy on enamel demineralization.

J Appl Oral Sci 2018 Dec 10;27:e20180044. Epub 2018 Dec 10.

Universidade Federal de Uberlândia, Faculdade de Odontologia, Departamento de Dentística e Materiais Odontológicos, Uberlândia, Minas Gerais, Brasil.

Objective: Radiation-related caries are one the most undesired reactions manifested during or after head and neck radiotherapy. Fluoride application is an important strategy to reduce demineralization and enhance remineralizaton. To evaluate the effect of the topical application of fluoride during irradiation on dental enamel demineralization. Read More

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December 2018

Inhibitory effect of reduced graphene oxide-silver nanocomposite on progression of artificial enamel caries.

J Appl Oral Sci 2018 Dec 10;27:e20180042. Epub 2018 Dec 10.

Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Hospital of Stomatology, Guanghua School of Stomatology, Guangzhou, China.

Objectives: The use of antimicrobial agents is an efficient method to prevent dental caries. Also, nanometric antibacterial agents with wide antibacterial spectrum and strong antibacterial effects can be applied for prevention of dental caries. The aim of this study was to evaluate the inhibitory effect of reduced graphene oxide-silver nanoparticles (rGO/Ag) composite on the progression of artificial enamel caries in a Streptococcus mutans biofilm model. Read More

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December 2018

Effect of topical ozonetherapy on gingival wound healing in pigs: histological and immuno-histochemical analysis.

J Appl Oral Sci 2018 Dec 10;27:e20180015. Epub 2018 Dec 10.

Gazi University, Faculty of Dentistry, Department of Oral Pathology, Ankara, Turkey.

Objectives: In this study, the effects of ozonetherapy on secondary wound healing were evaluated histologically and immuno-histochemically.

Material And Methods: Material and Methods: 8 healthy pigs were used in this study. Six wounds with 10 mm in diameter were created through the punch technique on the palatinal gingiva of each pig. Read More

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December 2018

[Evaluation of satisfaction with dental care from the standpoint of adult Brazilian users: a multilevel analysis].

Cien Saude Colet 2018 Dec;23(12):4339-4349

Departamento de Odontologia, Universidade Estadual de Montes Claros. Montes Claros MG Brasil.

The scope of this paper was to evaluate the satisfaction regarding dental care services and to identify the association between dissatisfaction and contextual/individual variables. It involved a cross-sectional study of a representative sample of 8,943 adults from 177 municipalities, in which 14.9% of adults were dissatisfied. Read More

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December 2018

[Training in Family Health and its association with work processes of Primary Care Dentistry Teams].

Cien Saude Colet 2018 Dec;23(12):4319-4329

Departamento de Odontologia Preventiva e Social, Faculdade de Odontologia, UFRGS. Porto Alegre RS Brasil.

The National Oral Health Policy emphasizes the importance of training in Primary Health Care and adapting the work processes to the new health care model. This study seeks to investigate the association between the training of Dental-Surgeons in Family Health and the work process. It involved a cross-sectional and multicentric study, with 18,114 Oral Health Teams that participated on the National Program to Enhance Access and Quality of Primary Health Care. Read More

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December 2018

Regular use of dental services and dental loss among the elderly.

Cien Saude Colet 2018 Dec;23(12):4269-4276

Faculdade de Odontologia, Universidade Federal de Pelotas. R. Gonçalves Chaves 457/510, Centro. 96015-560 Pelotas RS Brasil.

This study aimed to investigate the association between regular use of dental services and tooth loss by elderly linked to eleven Family Health Facilities in southern Brazil. This cross-sectional study evaluated 438 elderly. A standard questionnaire was used and oral health clinical variables were obtained by a trained dentist. Read More

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December 2018

Report from a symposium on accelerating policy-driven action against excessive sugar consumption for the prevention of early childhood caries and noncommunicable diseases.

Indian J Public Health 2018 Oct-Dec;62(4):305-307

Former SRF, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.

Dental diseases and other noncommunicable diseases (NCDs) share common risks. Omnipresent and easily available sugars are a contributing risk factor for overweight, obesity, and diabetes. In addition, sugar consumption is known to cause dental caries in early childhood (early childhood caries) and in adults. Read More

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December 2018

Influence of tobacco chewing on oral health: A hospital-based cross-sectional study in Odisha.

Indian J Public Health 2018 Oct-Dec;62(4):282-286

Postgraduate Student, Department of Public Health Dentistry, Meenakshi Ammal Dental College, Chennai, Tamil Nadu, India.

Background: Smokeless tobacco use in the Indian subcontinent is a part of many religious and cultural rituals and has gained a degree of social acceptance. The deleterious effects of smokeless tobacco are not as well-known as those produced by smoking.

Objectives: The study was carried out to assess the influence of tobacco chewing on the oral health of adult patients attending the dental outpatients department of Khordha district headquarter, Odisha. Read More

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December 2018

Oral health-related quality of life among male subjects with oral submucous fibrosis in a tertiary care hospital.

Indian J Public Health 2018 Oct-Dec;62(4):271-276

Senior Resident, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, Union Territory, India.

Background: Oral submucous fibrosis is very common in Asia. It has many deleterious effects on individual's oral functions. Thus, there is a need to assess the effect of oral submucous fibrosis on quality of life. Read More

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December 2018

Ultrasonographic diagnosis of benign masseter muscle hypertrophy: A case report.

J Cancer Res Ther 2018 Dec;14(Supplement):S1237-S1240

Department of Conservative and Endodontics, Index Institute of Dental Sciences, Indore, Madhya Pradesh, India.

Masseter hypertrophy is a characteristic condition resulting from an increase in the size of the muscle mass. At times, it produces significant facial asymmetry and is an important finding in the differential diagnosis of similar located entities. A proper diagnosis of this condition would avoid more aggressive and unwarranted therapy by an inexperienced clinician who may mistake it for a more serious pathologic condition. Read More

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December 2018

Oral submucous fibrosis - Is it time to modify the definition?

Oral Oncol 2018 Dec 24;87:203. Epub 2018 Oct 24.

Department of Oral Medicine and Radiology, The Oxford Dental College, Bangalore, India.

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December 2018

Elevated regulatory T cells at diagnosis of Coccidioides infection associates with chronicity in pediatric patients.

J Allergy Clin Immunol 2018 Dec 26;142(6):1971-1974.e7. Epub 2018 Oct 26.

Department of Molecular and Cell Biology, School of Natural Sciences, University of California Merced, Merced, Calif; Health Sciences Research Institute, University of California Merced, Merced, Calif. Electronic address:

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December 2018

Assessment of the Safety of the New Hybrid Pencil Type Energy (NP) Device Used Close to the Recurrent Laryngeal Nerve in a Porcine Model: Comparison With a Conventional Electrosurgical Knife.

Surg Innov 2018 Dec 12:1553350618817646. Epub 2018 Dec 12.

1 Keio University, School of Medicine Tokyo, Japan.

Background: Recurrent laryngeal nerve (RLN) paralysis is mainly associated with esophagectomy, and it may result in not only other morbidities, such as aspiration pneumonia, but also in long-term issues. Therefore, an approach to prevent RLN paralysis is necessary. The present study was designed to determine the technical usability of the new hybrid pencil type energy (NP) device developed by Olympus Corporation (Tokyo, Japan) and compare it with a conventional electrosurgical knife (EK) for resection around the RLN lymph nodes. Read More

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December 2018

Determination of Anti-aquaporin 5 Autoantibodies by Immunofluorescence Cytochemistry.

Methods Mol Biol 2019 ;1901:79-87

Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea.

Cell-based assay by immunofluorescence cytochemistry (CBA-IFC) has been shown to be the most accurate method to detect anti-aquaporin (AQP) 4 autoantibodies. Detection of anti-AQP5 autoantibodies is delicate, which depends on the proper expression of AQP5 on the plasma membrane. Here, we describe methods to determine anti-AQP5 autoantibodies by CBA-IFC. Read More

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January 2019

Interfering with bromodomain epigenome readers as therapeutic option in mucoepidermoid carcinoma.

Cell Oncol (Dordr) 2018 Dec 11. Epub 2018 Dec 11.

Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, 1011 N University Ave, Room 2029C, Ann Arbor, MI, 48109-1078, USA.

Purpose: Emerging evidence indicates that bromodomains comprise a conserved class of epigenome readers involved in cancer development and inflammation. Bromodomains are associated with epigenetic modifications of gene transcription through interactions with lysine residues of histone tails. Particularly, the bromodomain and extra-terminal domain (BET) family member BRD4 has been found to be involved in the control over oncogenes, including c-MYC, and in the maintenance of downstream inflammatory processes. Read More

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December 2018

Acute triflumuron exposure induces oxidative stress responses in liver and kidney of Balb/C mice.

Environ Sci Pollut Res Int 2018 Dec 11. Epub 2018 Dec 11.

Laboratory for Research on Biologically Compatible Compounds, Faculty of Dental Medicine, Rue Avicenne, 5019, Monastir, Tunisia.

Triflumuron (TFM) is one of the most widely used insecticides over the world. It is a benzoylphenyl urea that belongs to the class of insect growth regulators. This insecticide acts by inhibiting insect's chitin synthesis and by consequences, making insect more susceptible to pathogens and malformations. Read More

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December 2018

Deep-learning classification using convolutional neural network for evaluation of maxillary sinusitis on panoramic radiography.

Oral Radiol 2018 Dec 11. Epub 2018 Dec 11.

Department of Oral and Maxillofacial Radiology, Aichi-Gakuin University School of Dentistry, 2-11 Suemori-dori, Chikusa-ku, Nagoya, 464-8651, Japan.

Objectives: To apply a deep-learning system for diagnosis of maxillary sinusitis on panoramic radiography, and to clarify its diagnostic performance.

Methods: Training data for 400 healthy and 400 inflamed maxillary sinuses were enhanced to 6000 samples in each category by data augmentation. Image patches were input into a deep-learning system, the learning process was repeated for 200 epochs, and a learning model was created. Read More

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December 2018

Reliability and intra-examiner agreement of orthodontic model analysis with a digital caliper on plaster and printed dental models.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Orthodontics, University Hospital Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.

Objective: To investigate if orthodontic model analysis with a digital caliper can be interchangeably performed between plaster and printed dental models.

Materials And Methods: Forty-eight plaster models were digitized with orthoX®scan (DENTAURUM) and 48 counterparts were printed with Objet30 Dental Prime (Stratasys). One examiner performed five repeated orthodontic model analyses (41 outcomes) with a digital caliper in each plaster and the corresponding printed model and was externally validated by a second examiner. Read More

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December 2018

Cytokine levels in crevicular fluid associated with compliance during periodontal maintenance therapy.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

Department of Dental Clinics, Oral Pathology, and Oral Surgery, School of Dentistry, Federal University of Minas Gerais, Antônio Carlos Avenue, 6627, Pampulha, PO Box 359, Belo Horizonte, Minas Gerais, 31270-901, Brazil.

Objectives: To longitudinally evaluate the effects of compliance during periodontal maintenance therapy (PMT) on cytokines levels and its relation to periodontal status.

Materials And Methods: Ninety-one eligible individuals were selected from a 6-year prospective study with 212 individuals in PMT. From this total, 28 regular compliers (RC) were randomly selected and matched for age and gender with 28 irregular compliers (IC). Read More

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December 2018

Estrogen receptor gene is associated with dental fluorosis in Brazilian children.

Clin Oral Investig 2018 Dec 11. Epub 2018 Dec 11.

School of Health and Biological Sciences, Universidade Positivo, Rua Professor Pedro Viriato Parigot de Souza, 5300, Campo Comprido, Curitiba, Paraná, 80740-050, Brazil.

Objectives: The aim of this study was investigate the association between genetic polymorphisms in ESR1, ESR2, and ESRRB and dental fluorosis (DF) in a well-characterized sample of children from Curitiba, Brazil.

Material And Methods: From a representative sample of 538 children, 12-year-old were evaluated. DF was assessed in erupted permanent teeth by the Dean's index modified. Read More

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December 2018

The radioanatomical assessment of the Körner's septum.

Surg Radiol Anat 2018 Dec 11. Epub 2018 Dec 11.

Department of Dental and Maxillofacial Radiology, The Medical University of Warsaw, 59 Nowogrodzka St, 02006, Warsaw, Poland.

Purpose Of The Study: Körner's septum (KS) is a developmental remnant formed at the junction of mastoid and temporal squama, representing the persistence of the petrosquamosal suture. During mastoid surgery, it could be taken as a false medial wall of the antrum so that the deeper cells might not be explored. The aim of the study was to assess a Körner's septum prevalence and to analyze its topography. Read More

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December 2018

Development of an analytical prepCheck-supported approach to evaluate tutor-based assessments of dental students' practical skills.

Int J Comput Dent 2018 ;21(4):313-322

The aim of the present study was to develop an analytical computer-supported assessment concept for the objective evaluation of students' practical skills, and to investigate the assessor-dependent differences by setting tolerance limits applied during the 'glance and grade' evaluation. A sample of 54 conventionally supervised dental undergraduates were given training in the preparation of a macroretentive Class II cavity. The course participants then took a mandatory practical examination. Read More

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January 2018

A comparison of crown preparation grading via PrepCheck versus grading by dental school instructors.

Int J Comput Dent 2018 ;21(4):305-311

Recent reports in the literature demonstrate the influence that digital dentistry is having on the preclinical training of dental students. However, none of these articles have discussed the use of PrepCheck (Sirona Dental Systems) in the evaluation of preparation taper in a preclinical environment. The present study compared the subjective grading of student tooth preparations by experienced, well-calibrated faculty with objective digital grading of the same preparations by means of the PrepCheck software. Read More

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January 2018

Quality improvement of functional diagnostics in dentistry through computer-aided diagnosis: a randomized controlled trial.

Int J Comput Dent 2018 ;21(4):281-294

Functional diagnostic examinations such as clinical functional analysis and manual structural analysis ('orthopedic tests') allow the dentist to establish a structured diagnosis. Previously, the process of correlating findings with the appropriate diagnoses was guided by human thought processes alone. The experimental diagnostic randomized controlled trial (RCT) in this study investigated whether computer-aided diagnosis (CADx) of temporomandibular disorders (TMD) offers quality advantages over traditional diagnosis (TRAD). Read More

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January 2018

The Effect of Chlorhexidine and Listerine® Mouthwashes on the Tensile Strength of Selected Absorbable Sutures: An Study.

Biomed Res Int 2018 13;2018:8531706. Epub 2018 Nov 13.

Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, P.O. Box 60169, Riyadh 11545, Saudi Arabia.

Background: Suturing plays a critical role in the healing of surgical wounds. The tensile strength of suture materials indicates the ability of the material to withstand stress during knotting and protect the wound during an extended period of healing.

Objective: An in vitro study was conducted to determine the effect of two commercially available mouthwashes on the tensile strength and breakage mode of two absorbable intraoral sutures. Read More

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November 2018

Improvement of Diabetes Mellitus Symptoms by Intake of Ninjin'yoeito.

Front Nutr 2018 27;5:112. Epub 2018 Nov 27.

Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Diabetes mellitus is a well-known common disease and one of the most serious social problems in the worldwide. Although various types of drugs are developed, the number of patients suffering from diabetes mellitus is still increasing. Ninjin'yoeito (NYT) is one of formulas used in Japanese traditional herbal medicines for improving various types of metabolic disorders. Read More

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November 2018

The effect of botulinum toxin-A injection into the masseter muscles on prevention of plate fracture and post-operative relapse in patients receiving orthognathic surgery.

Maxillofac Plast Reconstr Surg 2018 Dec 25;40(1):36. Epub 2018 Nov 25.

Department of Oral and Maxillofacial Surgery, College of Dentistry, Gangneung-Wonju National University, Jukheon gil 7, Gangneung, Gangwondo 25457 Republic of Korea.

Background: Botulinum toxin-A (BTX-A) injection into muscle reduces muscular power and may prevent post-operative complication after orthognathic surgery. The purpose of this study was (1) to evaluate BTX-A injection into the masseter muscle on the prevention of plate fracture and (2) to compare post-operative relapse between the BTX-A injection group and the no injection group.

Methods: Sixteen patients were included in this study. Read More

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December 2018

Mandibular reconstruction with a ready-made type and a custom-made type titanium mesh after mandibular resection in patients with oral cancer.

Maxillofac Plast Reconstr Surg 2018 Dec 25;40(1):35. Epub 2018 Nov 25.

Department of Oral and Maxillofacial Surgery, School of Dentistry, Pusan National University, 20, Geumo-ro, Mulgeum-eup, Yangsan, Gyeongsangnam-do South Korea.

Background: After the resection at the mandibular site involving oral cancer, free vascularized fibular graft, a type of vascularized autograft, is often used for the mandibular reconstruction. Titanium mesh (T-mesh) and particulate cancellous bone and marrow (PCBM), however, a type of non-vascularized autograft, can also be used for the reconstruction. With the T-mesh applied even in the chin and angle areas, an aesthetic contour with adequate strength and stable fixation can be achieved, and the pores of the mesh will allow the rapid revascularization of the bone graft site. Read More

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December 2018

Interactions Between Immunotoxins and the Plasma Membrane: Implications for CAT-8015 Immunotoxin Therapy.

Front Oncol 2018 27;8:553. Epub 2018 Nov 27.

College of Engineering, Mathematics and Physical Sciences, Department of Physics and Astronomy, University of Exeter, Exeter, United Kingdom.

Acute Lymphoblastic Leukemia (ALL) remains the most frequent cause of cancer-related mortality in children and novel therapies are needed for the treatment of relapsed/refractory childhood ALL. One approach is the targeting of ALL blasts with the immunotoxin CAT-8015. Although CAT-8015 has potent anti-leukemia activity, with a 32% objective response rate in a phase 1 study of childhood ALL, haemolytic-uremic syndrome (HUS) and vascular leak syndrome (VLS), major dose-limiting toxicities, have limited the use of this therapeutic approach in children. Read More

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November 2018

Characteristics of dental patients determining their compliance level in dentistry: relevance for predictive, preventive, and personalized medicine.

EPMA J 2018 Dec 13;9(4):379-385. Epub 2018 Nov 13.

5Department of General and Clinical Psychology, Pavlov First Saint Petersburg State Medical University, 6/8 Lva Tolstogo Street, St. Petersburg, Russia.

This article centers on the relationship between psychological specifics of dental patients and their adherence to treatment. It describes clinical and personality specifics of periodontal patients and presents personality characteristics of patients with positive and negative dynamics of the therapy, as well as patients without periodontal diseases. The study findings highlight the importance of building confidential relationships with the patient and the need for a client-oriented approach to developing treatment plans and strategies for different types of dental patients. Read More

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December 2018

Dental Care for Patients with End-Stage Renal Disease and Undergoing Hemodialysis.

Int J Dent 2018 13;2018:9610892. Epub 2018 Nov 13.

Unit of Periodontology and Dental Hygiene, School of Dental Sciences, Department of Medical, Surgical and Health Sciences, University of Trieste, Italy.

Chronic renal failure is a progressive disease characterized by a gradual destruction of nephrons and a consequent reduction of kidney function. End-stage renal disease (ESRD) necessitates renal replacement therapy as peritoneal dialysis, hemodialysis, or transplantation. Patients affected by ESRD or in hemodialysis are at risk for developing a number of comorbidities including hypertension, anemia, risk of bleeding, susceptibility to infection, medication side effects, and oral manifestations associated with the disease itself and with hemodialysis treatment. Read More

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November 2018

Students' perception, attitudes, and readiness toward online learning in dental education in Saudi Arabia: a cohort study.

Adv Med Educ Pract 2018 22;9:855-863. Epub 2018 Nov 22.

Department of Advanced General Dentistry, The Dental Hospital, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.

Purpose: The purpose of this study was to assess students' perception, attitudes, and readiness toward online dental education in Saudi Arabia.

Materials And Methods: This is a longitudinal study using a 5-point Likert scale questionnaire distributed to a cohort group of undergraduate dental students at King Abdulaziz University, Faculty of Dentistry, Jeddah, Saudi Arabia, during their fourth year (T1) and internship year (T2). It assessed technological access, computer skills, online skills, and motivation level in using e-learning for personal and learning purposes; and overall readiness for e-learning adoption in dental education. Read More

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November 2018

10 kHz spinal cord stimulation: a retrospective analysis of real-world data from a community-based, interdisciplinary pain facility.

J Pain Res 2018 20;11:2929-2941. Epub 2018 Nov 20.

Division of Biostatistics and Experimental Design, Tufts School of Dental Medicine, Boston, MA, USA.

Objective: To evaluate clinical outcomes and health care utilization at 12 months post spinal cord stimulator (SCS) implantation compared with baseline and a matched sample of patients receiving conventional medical management (CMM) for the treatment of low back and lower extremity pain.

Patients: A retrospective study of patients with at least 24 months of active treatment at an interdisciplinary community pain center between December 1, 2014 and December 31, 2017. Thirty-two patients receiving implantation of a high-frequency (10 kHz) SCS and 64 patients receiving CMM were identified through propensity matching at a ratio of 2:1. Read More

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November 2018

The role of promoter gene polymorphisms in causing hypodontia: a study in the Jordanian population.

Appl Clin Genet 2018 21;11:145-149. Epub 2018 Nov 21.

Department of Applied Dental Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan.

Background: The congenital absence of one or few teeth, hypodontia, is considered one of the utmost dental ageneses in human beings. Several genes have been shown to be involved in the development of hypodontia such as paired box gene 9 (). The expression of is controlled by several polymorphic elements in the promoter region of the gene on 14q13. Read More

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November 2018

A 10-point plan for avoiding hyaluronic acid dermal filler-related complications during facial aesthetic procedures and algorithms for management.

Clin Cosmet Investig Dermatol 2018 23;11:603-611. Epub 2018 Nov 23.

Institute of Medical and Biomedical Education, St George's University of London, London, UK.

The recent rapid growth in dermal filler use, in conjunction with inadequate product and injector control, has heralded a concerning increase in filler complications. The 10-point plan has been developed to minimize complications through careful preconsideration of causative factors, categorized as patient, product, and procedure related. Patient-related factors include history, which involves a preprocedural consultation with careful elucidation of skin conditions, systemic disease, medications, and previous cosmetic procedures. Read More

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November 2018
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Initial osteoblast adhesion and subsequent differentiation on zirconia surfaces are regulated by integrins and heparin-sensitive molecule.

Int J Nanomedicine 2018 19;13:7657-7667. Epub 2018 Nov 19.

Division of Advanced Prosthetic Dentistry, Graduate School of Dentistry, Tohoku University, Sendai, Japan.

Purpose: It is well known that zirconia materials have good biocompatibility; however, little is known regarding the mechanism by which cells attach to these materials. The purpose of this study is to elucidate the mechanism of cell attachment.

Materials And Methods: In this study, we examined the surface characteristics of ceria-stabilized zirconia/alumina nanocomposite (NANOZR), yttria-stabilized zirconia (Y-TZP) and commercially pure titanium (CpTi), and we evaluated the initial response of osteoblast-like cells to them with different inhibitors. Read More

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November 2018

Biomimetic intrafibrillar mineralized collagen promotes bone regeneration via activation of the Wnt signaling pathway.

Int J Nanomedicine 2018 21;13:7503-7516. Epub 2018 Nov 21.

Department of Oral & Maxillofacial-Head & Neck Oncology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Key Laboratory of Stomatology & Shanghai Research, Institute of Stomatology and National Clinical Research Center of Stomatology, Shanghai, China,

Purpose: The purpose of this study was to assess the effects of biomimetic intrafibrillar mineralized collagen (IMC) bone scaffold materials on bone regeneration and the underlying biological mechanisms.

Materials And Methods: A critical-sized bone defect in the rat femur was created; then IMC, extrafibrillar mineralized collagen, and nano-hydroxyapatite bone scaffold materials were grafted into the defect. Ten weeks after implantation, micro-computed tomography and histology were applied to evaluate the bone regeneration. Read More

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November 2018

Development of a novel RANKL-based peptide, microglial healing peptide1-AcN (MHP1-AcN), for treatment of ischemic stroke.

Sci Rep 2018 Dec 11;8(1):17770. Epub 2018 Dec 11.

Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Osaka, Japan.

Although the regulation of post-ischemic inflammation is an important strategy to treat ischemic stroke, all clinical trials have failed to show its efficacy. To solve the problem, we previously developed a novel partial peptide of RANKL, microglial healing peptide 1 (MHP1), which could reduce ischemic injury by inhibiting Toll-like receptor (TLR) induced inflammation. However, optimization of the peptide was necessary to increase the stability and efficacies for clinical use. Read More

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December 2018

-fucosylation of thrombospondin-like repeats is required for processing of microneme protein 2 and for efficient host cell invasion by tachyzoites.

J Biol Chem 2018 Dec 11. Epub 2018 Dec 11.

Molecular and Cell Biology, Boston University, United States.

is an intracellular parasite that causes disseminated infections that can produce neurological damage in fetuses and immunocompromised individuals. Microneme protein 2 (MIC2), a member of the thrombospondin-related anonymous protein (TRAP) family, is a secreted protein important for motility, host cell attachment, invasion, and egress. MIC2 contains six thrombospondin type I repeats (TSRs) that are modified by -mannose and -fucose in spp. Read More

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December 2018
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