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J Travel Med 2021 May 12. Epub 2021 May 12.

Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy.

Front Public Health 2021 27;9:601980. Epub 2021 Apr 27.

Department of Demography, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, Brazil.

What is the spatial pattern of mortality by cause and sex in Brazil? Even considering the main causes of death, such as neoplasms, cardiovascular diseases, external causes, respiratory diseases, and infectious diseases, there are still important debate regarding the spatial pattern of mortality by causes in Brazil. Evidence shows that there is an overlap in transitional health states, due to the persistence of infectious diseases (e.g. Read More

N Biotechnol 2021 May 10. Epub 2021 May 10.

Department of Immunology, DEPBIO, Faculty of Chemistry, Hygiene Institute, UDELAR, Av. A. Navarro 3051, 11600, Montevideo, Uruguay. Electronic address:

Nanobodies are the smallest antibody fragments which bind to antigens with high affinity and specificity. Due to their outstanding physicochemical stability, simplicity and cost-effective production, nanobodies have become powerful agents in therapeutic and diagnostic applications. In this work, the advantages of nanobodies were exploited to develop generic and standardized anti-human IgM reagents for serology and IgM B-cell analysis. Read More

Salud Publica Mex 2020 Dec 22;63(1, ene-feb):42-50. Epub 2020 Dec 22.

CIET/PRAM, Department of Family Medicine, McGill University, Montreal, Canada.

Objetivo. Identificar factores demográficos y clínicos asociados con la mortalidad por dengue grave en cinco de-partamentos de Colombia. Material y métodos. Read More

J Card Surg 2021 May 12. Epub 2021 May 12.

Department of Cardiac Surgery, CIMS Hospital, Ahmedabad, Gujarat, India.

Introduction: Primary cardiac synovial sarcoma is an exceedingly rare soft tissue malignant tumor, involving either the pericardium or chambers, with a striking male predominance, prevalently seen in the fourth decade. These tumours most commonly present as breathlessness on exertion. These patients readily exhibit gastrointestinal and systemic symptoms but sometimes the presentation can be fallacious. Read More

Heliyon 2021 Apr 20;7(4):e06785. Epub 2021 Apr 20.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Recent studies have shown that dengue virus (DENV) can efficiently infect bone marrow hematopoietic stem cells (HSCs) as well as the placenta of pregnant women. Although mother-to-infant vertical transmission of DENV through the placenta has been well documented, the evidence of cell-associated vertical transmission is still unknown. Whether DENV can infect umbilical cord blood (UCB) cells before reaching the fetus remains to be explored. Read More

Front Pharmacol 2021 26;12:610912. Epub 2021 Apr 26.

Department of Pharmacology, Faculty of Medicine, Universiti Kebangsaan Malaysia (The National University of Malaysia), Cheras, Malaysia.

Dengue, a very widespread mosquito-borne infectious disease caused by virus, has been occurring during the monsoons every year. The prevalence and incidence of dengue fever and death due to its complications have been increased drastically in these recent years in Bangladesh, Philippines, Thailand, Brazil, and India. Recently, dengue had spread in an epidemic form in Bangladesh, Thailand, and Philippines. Read More

Sci Rep 2021 May 12;11(1):10136. Epub 2021 May 12.

Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tokyo, 135-0064, Japan.

Pathogenic mosquito-borne viruses are a serious public health issue in tropical and subtropical regions and are increasingly becoming a problem in other climate zones. Drug repositioning is a rapid, pharmaco-economic approach that can be used to identify compounds that target these neglected tropical diseases. We have applied a computational drug repositioning method to five mosquito-borne viral infections: dengue virus (DENV), zika virus (ZIKV), West Nile virus (WNV), Japanese encephalitis virus (JEV) and Chikungunya virus (CHIV). Read More

J Clin Microbiol 2021 May 12. Epub 2021 May 12.

Arbovirus Diseases Branch, Division of Vector-Borne Diseases, U.S. Centers for Disease Control, Fort Collins, CO

Dengue viruses (DENV) and Zika virus (ZIKV) are related mosquito-borne flaviviruses with similar disease manifestations, vector ecology and geographic range. The ability to differentiate these viruses serologically is vital due to the teratogenic nature of ZIKV and the potential confounding of pre-existing cross-reactive anti-DENV antibodies. Here we illustrate the kinetics of the IgM neutralizing antibody (NAb) response using longitudinal samples ranging from acute ZIKV infection to late convalescence from individuals with evidence of prior DENV infection. Read More

J Virol 2021 May 12. Epub 2021 May 12.

Department of Biochemistry and Molecular Biology, Faculty of Agriculture and Life Science, Hirosaki University, Aomori, Japan

Many positive-stranded RNA viruses encode polyproteins and viral proteins are generated by processing the polyproteins. This system produces an equal amount of each viral protein, though their required amounts are different. In this study, we found that the extra membrane-anchored non-structural (NS) proteins of Japanese encephalitis virus and dengue virus are rapidly and selectively degraded by the endoplasmic reticulum-associated degradation (ERAD) pathway. Read More

Methods Mol Biol 2021 ;2296:279-302

Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Kuala Lumpur, Selangor, Malaysia.

Dengue is an arthropod-borne viral disease that has become endemic and a global threat in over 100 countries. The increase in prevalence would require a long-term measure to control outbreaks. Sanofi Pasteur has licensed the tetravalent dengue vaccine (Dengvaxia) in certain dengue endemic countries. Read More

Commun Biol 2021 05 11;4(1):557. Epub 2021 May 11.

Department of Cell and Molecular Biology, QIMR Berghofer Medical Research Institute, Herston, QLD, Australia.

Dengue virus (DENV) is spread from human to human through the bite of the female Aedes aegypti mosquito and leads to about 100 million clinical infections yearly. Treatment options and vaccine availability for DENV are limited. Defective interfering particles (DIPs) are considered a promising antiviral approach but infectious virus contamination has limited their development. Read More

Sci Rep 2021 May 11;11(1):10039. Epub 2021 May 11.

Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno Vetor, Instituto René Rachou, Fiocruz Minas, Belo Horizonte, MG, Brazil.

Field release of Wolbachia-infected Aedes aegypti has emerged as a promising solution to manage the transmission of dengue, Zika and chikungunya in endemic areas across the globe. Through an efficient self-dispersing mechanism, and the ability to induce virus-blocking properties, Wolbachia offers an unmatched potential to gradually modify wild Ae. aegypti populations turning them unsuitable disease vectors. Read More

Nat Commun 2021 May 11;12(1):2619. Epub 2021 May 11.

Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.

After the Zika virus (ZIKV) epidemic in the Americas in 2016, both Zika and dengue incidence declined to record lows in many countries in 2017-2018, but in 2019 dengue resurged in Brazil, causing ~2.1 million cases. In this study we use epidemiological, climatological and genomic data to investigate dengue dynamics in recent years in Brazil. Read More

PLoS Negl Trop Dis 2021 May 11;15(5):e0008212. Epub 2021 May 11.

Escuela de Investigación en Biomatemáticas, Universidad del Quindío, Armenia, Quindío, Colombia.

In Colombia, little is known on the distribution of the Asian mosquito Aedes albopictus, main vector of dengue, chikungunya, and Zika in Asia and Oceania. Therefore, this work sought to estimate its current and future potential geographic distribution under the Representative Concentration Paths (RCP) 2.6 and 8. Read More

Trop Biomed 2021 Jun;38(2):79-84

Department of Chemistry, Faculty of Science, Universiti Malaya, 50603 Kuala Lumpur, Malaysia.

The NS2B/NS3 protease is crucial for the pathogenesis of the DENV. Therefore, the inhibition of this protease is considered to be the key strategy for the development of new antiviral drugs. In the present study, malabaricones C (3) and E (4), acylphenols from the fruits of Myristica cinnamomea King, have been respectively identified as moderate (27. Read More

Adv Exp Med Biol 2021 ;1318:333-341

Department of Community Medicine, Dr. DY Patil University, Pune, India.

COVID-19 is a newly emerging pandemic caused by a novel coronavirus. After its first report in China in December 2019, the disease already spread and affected more than 200 countries worldwide. It correlates with different phenotypes ranging from an acute febrile illness to severe respiratory problems. Read More

Sci Rep 2021 May 10;11(1):9916. Epub 2021 May 10.

Centre for Geographical Studies, Institute of Geography and Spatial Planning, Universidade de Lisboa, Lisbon, Portugal.

The Asian tiger mosquito (Aedes albopictus), a vector of dengue, Zika and other diseases, was introduced in Europe in the 1970s, where it is still widening its range. Spurred by public health concerns, several studies have delivered predictions of the current and future distribution of the species for this region, often with differing results. We provide the first joint analysis of these predictions, to identify consensus hotspots of high and low suitability, as well as areas with high uncertainty. Read More

Eur J Obstet Gynecol Reprod Biol 2021 Apr 30;261:205-210. Epub 2021 Apr 30.

Sidra Medicine, Education City, Al Luqta Street, Doha, Qatar.

Dengue is the most common viral mosquito- borne disease. It is a major public health problem, especially in tropical and sub-tropical areas worldwide. According to the World Health Organization (WHO), approximately 40% of the world's population (over 2. Read More

PLoS Negl Trop Dis 2021 May 10;15(5):e0009393. Epub 2021 May 10.

Medical Zoology Pole, Institut Pasteur de Dakar, Dakar, Sénégal.

Aedes aegypti is the main epidemic vector of arboviruses in Africa. In Senegal, control activities are mainly limited to mitigation of epidemics, with limited information available for Ae. aegypti populations. Read More

Am J Trop Med Hyg 2021 May 10. Epub 2021 May 10.

4Sanofi Pasteur, Lyon, France.

Dengue patients with comorbidities may be at higher risk of death. In this cross-sectional study, healthcare databases from Mexico (2008-2014), Brazil (2008-2015), and Colombia (2009-2017) were used to identify hospitalized dengue cases and their comorbidities. Case fatality rates (CFRs), relative risk, and odds ratios (OR) for in-hospital mortality were determined. Read More

JMIR Public Health Surveill 2021 May 10;7(5):e19502. Epub 2021 May 10.

Graduate School of Engineering (COPPE), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Background: Aedes aegypti is a vector for the transmission of diseases such as dengue fever, chikungunya, Zika fever, and yellow fever. In 2016, over 1 million cases of these diseases were reported in Brazil, which is an alarming public health issue. One of the ways of controlling this disease is by inspecting and neutralizing the places where A. Read More

Mol Ther Methods Clin Dev 2021 May 1. Epub 2021 May 1.

National Center for Genetic Engineering and Biotechnology, Klong Luang, Pathumthani 12120.

With sequencing as a standard frontline protocol to identify emerging viruses such Zika virus and SARS-CoV-2, direct utilization of sequence data to program antivirals against the viruses could accelerate drug development to treat their infections. CRISPR-Cas effectors are promising candidates that could be programmed to inactivate viral genetic material based on sequence data but several challenges such as delivery and design of effective crRNA need to be addressed to realize practical use. Here, we showed that virus-like particle (VLP) could deliver PspCas13b-crRNA ribonucleoprotein (RNP) in nanomolar range to efficiently suppress dengue virus infection in primary human target cells. Read More

Cureus 2021 Apr 5;13(4):e14294. Epub 2021 Apr 5.

Department of Medicine, Dr Soliman Fakeeh Hospital, Jeddah, SAU.

The renal complications of dengue virus infection cover a wide spectrum of manifestations from acute kidney injury to glomerular injury with nephritic/nephrotic syndrome. Majority of cases remain symptom free and show full recovery. We present a 61-year-old previously healthy male who developed a pyrexial illness with haemolytic anaemia that was diagnosed on the basis of a positive serological test as a case of dengue fever. Read More

Front Immunol 2021 21;12:630571. Epub 2021 Apr 21.

Department of Biological Sciences, Old Dominion University, Norfolk, VA, United States.

Tetraspanin family of proteins participates in numerous fundamental signaling pathways involved in viral transmission, virus-specific immunity, and virus-mediated vesicular trafficking. Studies in the identification of novel therapeutic candidates and strategies to target West Nile virus, dengue and Zika viruses are highly warranted due to the failure in development of vaccines. Recent evidences have shown that the widely distributed tetraspanin proteins may provide a platform for the development of novel therapeutic approaches. Read More

Chaos Solitons Fractals 2021 May 4:111008. Epub 2021 May 4.

Department of Mathematics, Anand International College of Engineering, Jaipur 303012, India.

Recently, four new strains of SARS-COV-2 were reported in different countries which are mutants and considered as 70 more dangerous than the existing covid-19 virus. In this paper, hybrid mathematical models of new strains and co-infection in Caputo, Caputo-Fabrizio, and Atangana-Baleanu are presented. The idea behind this co-infection modeling is that, as per medical reports, both dengue and covid-19 have similar symptoms at the early stages. Read More

Rev Esp Salud Publica 2021 May 10;95. Epub 2021 May 10.

Servicio de Sanidad y Consumo. Ayuntamiento de València. Valencia. España.

Objective: Environmental management of imported arboviruses such as dengue (DENV), Zika (ZIKV) or Chikungunya (CHIKV) is a task of great significance for Public Health since the arrival and establishment of the competent vector Aedes albopictus (Asian tiger mosquito) in numerous cities of our country. There are recent examples of autochthonous transmission of some of these arboviruses in Spain probably linked to undetected and / or unmanaged imported cases.

Methods: Vector management interventions were carried out in the city of Valencia (Spain) by the Health Service of the Valencia City Council between 2016 and 2018. Read More

J Prim Care Community Health 2021 Jan-Dec;12:21501327211013298

Pruthai Primary Care Unit, Surat Thani, Thailand.

Background: Risk assessment criteria for predicting dengue outbreak must be appropriated at village levels. We aimed to develop risk dengue village prediction criteria, predict village dengue risk, and strengthen dengue prevention based on community participation.

Methods: This participatory research conducted in Southern Thailand included the following 5 phases: (i) preparing communities in 3 districts; (ii) developing risk dengue village prediction criteria; (iii) applying computer program; (iv) predicting village dengue risk with 75 public health providers in 39 PCUs; and (v) utilizing findings to strengthen dengue prevention activities in 220 villages. Read More

Colloids Surf B Biointerfaces 2021 May 4;204:111820. Epub 2021 May 4.

Key Laboratory of Ministry of Education for Medicinal Plant Resource and Natural Pharmaceutical Chemistry, Shaanxi Normal University, Xi'an, China; School of Life Sciences, Shaanxi Normal University, Xi'an, China. Electronic address:

According to the world health organization (WHO) 2020 report, vector borne diseases account for 17 % of all infections with reported 700 thousand death each year. They are of considerable importance to health professionals as they are posing a serious health threat and include dengue fever, Zika fever, chikungunya, yellow fever, and other disease agents. Aedes aegypti serve as a vector for transmitting several of these tropical fevers. Read More

Lancet Planet Health 2021 May;5(5):e277-e285

Department of Environmental Sciences, Emory University, Atlanta, GA, USA. Electronic address:

Background: Effective Aedes aegypti control is limited, in part, by the difficulty in achieving sufficient intervention coverage. To maximise the effect of vector control, areas with persistently high numbers of Aedes-borne disease cases could be identified and prioritised for preventive interventions. We aimed to identify persistent Aedes-borne disease hotspots in cities across southern Mexico. Read More