20,876 results match your criteria Dengue Fever


Plasmacytoid Dendritic Cells and Infected Cells Form an Interferogenic Synapse Required for Antiviral Responses.

Cell Host Microbe 2019 Apr 15. Epub 2019 Apr 15.

CIRI, Inserm, U1111, Université Claude Bernard Lyon 1, CNRS, UMR5308, École Normale Supérieure de Lyon, Univ Lyon, Lyon F-69007, France. Electronic address:

Type I interferon (IFN-I) is critical for antiviral defense, and plasmacytoid dendritic cells (pDCs) are a predominant source of IFN-I during virus infection. pDC-mediated antiviral responses are stimulated upon physical contact with infected cells, during which immunostimulatory viral RNA is transferred to pDCs, leading to IFN production via the nucleic acid sensor TLR7. Using dengue, hepatitis C, and Zika viruses, we demonstrate that the contact site of pDCs with infected cells is a specialized platform we term the interferogenic synapse, which enables viral RNA transfer and antiviral responses. Read More

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http://dx.doi.org/10.1016/j.chom.2019.03.005DOI Listing

Synthesis and biological evaluation of novel imidazole nucleosides as potential anti-dengue virus agents.

Bioorg Med Chem 2019 Apr 8. Epub 2019 Apr 8.

Graduate School of Pharmaceutical Science, Tokushima University, Shomachi 1-78-1, Tokushima 770-8505, Japan. Electronic address:

In this work, we developed imidazole nucleoside derivatives with anti-dengue virus (DENV) activity was examined. First, compounds in a nucleosides library were screened to find lead compounds which inhibit replication of DENV. As a result, 5-ethynyl-(1-β-d-ribofuranosyl)imidazole-4-carboxamide (1; EICAR) and its 4-carbonitrile derivative EICNR (2) were selected as promising antiviral compounds. Read More

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http://dx.doi.org/10.1016/j.bmc.2019.04.015DOI Listing

Production and Biomedical Application of Flavivirus-like Particles.

Trends Biotechnol 2019 Apr 16. Epub 2019 Apr 16.

Department of Recombinant Vaccines, Intercollegiate Faculty of Biotechnology, University of Gdansk and Medical University of Gdansk, Abrahama 58, 80-307 Gdansk, Poland. Electronic address:

Many viruses belonging to the Flaviviridae family are transmitted by invertebrate vectors. Among those transmitted by mosquitos, there are many human pathogens of great medical importance, such as Japanese encephalitis virus, West Nile virus, dengue virus, Zika virus, or yellow fever virus. Millions of people contract mosquito-borne diseases each year, leading to thousands of deaths. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01677799193007
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http://dx.doi.org/10.1016/j.tibtech.2019.03.013DOI Listing
April 2019
1 Read

Computational Analysis of Dengue Virus Envelope Protein (E) Reveals an Epitope with Flavivirus Immunodiagnostic Potential in Peptide Microarrays.

Int J Mol Sci 2019 Apr 18;20(8). Epub 2019 Apr 18.

Consiglio Nazionale delle Ricerche, Istituto di Chimica del Riconoscimento Molecolare (ICRM), Via Mario Bianco 9, 20131 Milano, Italy.

The mosquito-borne viral disease caused by the Dengue virus is an expanding global threat. Diagnosis in low-resource-settings and epidemiological surveillance urgently requires new immunoprobes for serological tests. Structure-based epitope prediction is an efficient method to design diagnostic peptidic probes able to reveal specific antibodies elicited in response to infections in patients' sera. Read More

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https://www.mdpi.com/1422-0067/20/8/1921
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http://dx.doi.org/10.3390/ijms20081921DOI Listing
April 2019
1 Read

Hierarchical Virtual Screening of Potential Insectides Inhibitors of Acetylcholinesterase and Juvenile Hormone from Temephos.

Pharmaceuticals (Basel) 2019 Apr 18;12(2). Epub 2019 Apr 18.

Postgraduate Program in-Network in Pharmaceutical Innovation, Federal University of Amapá, Macapá, AP 68902-280, Brazil.

(Linnaeus, 1762; Diptera: Culicidae) is the main vector transmitting viral diseases such as dengue fever, dengue haemorrhagic fever, urban yellow fever, zika and chikungunya. Worldwide, especially in the Americas and Brazil, many cases of dengue have been reported in recent years, which have shown significant growth. The main control strategy is the elimination of the vector, carried out through various education programs, to change human habits, but the most usual is biological control, together with environmental management and chemical control. Read More

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http://dx.doi.org/10.3390/ph12020061DOI Listing

Phylogenetic analysis of partial pre-membrane and envelope sequences of dengue viruses circulating in India.

Int J Infect Dis 2019 Apr 16. Epub 2019 Apr 16.

Dept. of Clinical Virology, Christian Medical College, Vellore 632004, Tamil Nadu, India. Electronic address:

Objective: Phylogenetic characteristics of circulating Indian dengue viruses (DENV) were analysed using partial pre-membrane (PrM) and envelope (E) sequences. An immunodominant region was analysed for mutations and alignment with common DENV PCR primers and probes was determined.

Methods: Published Indian PrM and E DENV sequences were analysed with hitherto unpublished PrM sequences from this study site. Read More

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http://dx.doi.org/10.1016/j.ijid.2019.04.010DOI Listing

Loss of cytoplasmic incompatibility in Wolbachia-infected Aedes aegypti under field conditions.

PLoS Negl Trop Dis 2019 Apr 19;13(4):e0007357. Epub 2019 Apr 19.

Pest and Environmental Adaptation Research Group, Bio21 Institute and the School of BioSciences, The University of Melbourne, Parkville, Victoria, Australia.

Wolbachia bacteria are now being introduced into Aedes aegypti mosquito populations for dengue control. When Wolbachia infections are at a high frequency, they influence the local transmission of dengue by direct virus blocking as well as deleterious effects on vector mosquito populations. However, the effectiveness of this strategy could be influenced by environmental temperatures that decrease Wolbachia density, thereby reducing the ability of Wolbachia to invade and persist in the population and block viruses. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007357
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http://dx.doi.org/10.1371/journal.pntd.0007357DOI Listing
April 2019
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A Rare Case of Thoracic Subdural Hematoma after Recovery from Dengue Fever.

J Neurosci Rural Pract 2019 Apr-Jun;10(2):380-381

Department of Anaesthesia and Critical Care, Armed Forces Medical College, Pune, Maharashtra, India.

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http://www.ruralneuropractice.com/text.asp?2019/10/2/380/254
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http://dx.doi.org/10.4103/jnrp.jnrp_314_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6454941PMC
April 2019
1 Read

"Honeycomb" pattern of gallbladder wall thickening - A forward step in early diagnosis of "Severe Dengue Fever".

Indian J Radiol Imaging 2019 Jan-Mar;29(1):14-18

Department of Radiology, Apollo Hospitals International Limited, Gandhinagar, India.

Aims And Objectives: To study "Honeycomb" pattern of gallbladder wall thickening (GBWT) in dengue fever (DF) and to assess its clinical significance in early diagnosis of severe DF.

Materials And Methods: A total 244 patients of DF were studied, 84 patients were classified as severe DF, 61 patients as DF with warning signs, and 99 patients as DF without warning signs. Abdominal ultrasound was performed for assessment of GBWT patterns, hepatomegaly, splenomegaly, pancreatic enlargement, ascites, pleural effusion, and other additional findings were recorded in severe DF cases. Read More

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http://dx.doi.org/10.4103/ijri.IJRI_363_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467033PMC

Attenuation of a dengue virus replicon by codon deoptimization of nonstructural genes.

Vaccine 2019 Apr 15. Epub 2019 Apr 15.

Department of Microbiology and Immunology, Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, Victoria, Australia; Institute of Vector Borne Disease, Monash University, Clayton, Victoria, Australia; Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, District 5, Ho Chi Minh City, Viet Nam. Electronic address:

The overwhelming increase of dengue virus (DENV) infections in recent years shows that current strategies to combat dengue do not work. The lack of a highly effective dengue vaccine and the limited effectivity of vector controls exacerbate this situation. To point the way to a novel method of creating DENV vaccine candidates, here we disrupted the codon usage in a DENV-2 reporter replicon to generate variants with different replication characteristics. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0264410X193041
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http://dx.doi.org/10.1016/j.vaccine.2019.03.062DOI Listing
April 2019
1 Read

Effect of standard dose paracetamol versus placebo as antipyretic therapy on liver injury in adult dengue infection: a multicentre randomised controlled trial.

Lancet Glob Health 2019 May;7(5):e664-e670

Division of Infectious Diseases, Phramongkutklao Hospital, Bangkok, Thailand.

Background: Dengue is a common cause of acute liver failure in tropical countries. Paracetamol is the recommended antipyretic for dengue. Related observational studies in dengue have suggested that excessive paracetamol intake is related to hepatic injury. Read More

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http://dx.doi.org/10.1016/S2214-109X(19)30032-4DOI Listing

Paracetamol for dengue fever: no benefit and potential harm?

Lancet Glob Health 2019 May;7(5):e552-e553

Mahidol Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. Electronic address:

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http://dx.doi.org/10.1016/S2214-109X(19)30157-3DOI Listing

Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models.

Emerg Microbes Infect 2019 ;8(1):624-636

a Department of Biotechnology , Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA) , Madrid , Spain.

Flaviviruses are (re)-emerging RNA viruses strictly dependent on lipid metabolism for infection. In the search for host targeting antivirals, we explored the effect of pharmacological modulation of fatty acid metabolism during flavivirus infection. Considering the central role of acetyl-Coenzyme A carboxylase (ACC) on fatty acid metabolism, we analyzed the effect of three small-molecule ACC inhibitors (PF-05175157, PF-05206574, and PF-06256254) on the infection of medically relevant flaviviruses, namely West Nile virus (WNV), dengue virus, and Zika virus. Read More

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https://www.tandfonline.com/doi/full/10.1080/22221751.2019.1
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http://dx.doi.org/10.1080/22221751.2019.1604084DOI Listing
January 2019
1 Read

Flooding in Townsville, North Queensland, Australia, in February 2019 and Its Effects on Mosquito-Borne Diseases.

Int J Environ Res Public Health 2019 Apr 17;16(8). Epub 2019 Apr 17.

Australian Institute of Tropical Health and Medicine, James Cook University, Townsville, QLD 4811, Australia.

In February 2019, a major flooding event occurred in Townsville, North Queensland, Australia. Here we present a prediction of the occurrence of mosquito-borne diseases (MBDs) after the flooding. We used a mathematical modelling approach based on mosquito population abundance, survival, and size as well as current infectiousness to predict the changes in the occurrences of MBDs due to flooding in the study area. Read More

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https://www.mdpi.com/1660-4601/16/8/1393
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http://dx.doi.org/10.3390/ijerph16081393DOI Listing
April 2019
1 Read

Reply to Comments on the Study "The Sensitivity, Specificity and Accuracy of Warning Signs in Predicting Severe Dengue, the Severe Dengue Prevalence and its Associated Factors".

Int J Environ Res Public Health 2019 Apr 17;16(8). Epub 2019 Apr 17.

Department of Community Medicine, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kota Bharu 16150, Kelantan, Malaysia.

Thank you for the comments received on the article "The Sensitivity, Specificity and Accuracy of Warning Signs in Predicting Severe Dengue, the Severe Dengue Prevalence and its Associated Factors" [... Read More

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http://dx.doi.org/10.3390/ijerph16081380DOI Listing

The possible role of cross-reactive dengue virus antibodies in Zika virus pathogenesis.

PLoS Pathog 2019 Apr 18;15(4):e1007640. Epub 2019 Apr 18.

Department of Viroscience, Erasmus Medical Center, Rotterdam, the Netherlands.

Zika virus (ZIKV) has been known for decades to circulate in Africa and Asia. However, major complications of a ZIKV infection have recently become apparent for reasons that are still not fully elucidated. One of the hypotheses for the seemingly increased pathogenicity of ZIKV is that cross-reactive dengue antibodies can enhance a ZIKV infection through the principle of antibody-dependent enhancement (ADE). Read More

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http://dx.plos.org/10.1371/journal.ppat.1007640
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http://dx.doi.org/10.1371/journal.ppat.1007640DOI Listing
April 2019
3 Reads

Incrimination of for dengue virus serotype-1 in Assam, Northeast India.

J Vector Borne Dis 2018 Oct-Dec;55(4):330-333

Division of Entomology and Filariasis, ICMR-Regional Medical Research Centre, Northeast Region, Dibrugarh, Assam, India.

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http://dx.doi.org/10.4103/0972-9062.256572DOI Listing
April 2019
2 Reads

The relationship between skin rash and outcome in dengue.

J Vector Borne Dis 2018 Oct-Dec;55(4):310-314

Department of General Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Background & Objectives: Dengue fever (DF) is a common cause of acute febrile illness. Skin involvement is seen in more than half of the patients. This study was aimed to compare the clinical profile and outcome in DF patients with or without skin involvement. Read More

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http://dx.doi.org/10.4103/0972-9062.256567DOI Listing
April 2019
2 Reads

Larvicidal activity of extract against mosquitoes.

J Vector Borne Dis 2018 Oct-Dec;55(4):282-290

World Health Organization, SEARO, New Delhi, India.

Background & Objectives: Vector control strategies play significant role in reducing the transmission of malaria, dengue and other vector-borne diseases. The control of vector population using synthetic insecticides has resulted in development of insecticide resistance and negative effects on humans and environment. The present investigation evaluated the larvicidal potential of methanol, dichloromethane and hexane extracts of leaves and seeds of Ricinus communis (castor) plant against the early IV instar larvae of the dengue vector, Aedes aegypti, and malaria vector, Anopheles culicifacies. Read More

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http://dx.doi.org/10.4103/0972-9062.256563DOI Listing
April 2019
2 Reads

Development of a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF) for targeted antibody blocking.

Chem Sci 2019 Mar 28;10(11):3271-3280. Epub 2019 Jan 28.

MOE Key Laboratory of Bioinformatics , Center for Synthetic and Systems Biology , School of Life Sciences , Tsinghua University , Beijing , China . Email:

Targeted antibody blocking enables characterization of binding sites on immunoglobulin G (IgG), and can efficiently eliminate harmful antibodies from organisms. In this report, we present a novel peptide-denoted as a dual-functional conjugate of antigenic peptide and Fc-III mimetics (DCAF)-for targeted blocking of antibodies. Synthesis of DCAF was achieved by native chemical ligation, and the molecule consists of three functional parts: a specific antigenic peptide, a linker and the Fc-III mimetic peptide, which has a high affinity toward the Fc region of IgG molecules. Read More

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http://xlink.rsc.org/?DOI=C8SC05273E
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http://dx.doi.org/10.1039/c8sc05273eDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429600PMC
March 2019
1 Read

Scaffold Morphing Approach To Expand the Toolbox of Broad-Spectrum Antivirals Blocking Dengue/Zika Replication.

ACS Med Chem Lett 2019 Apr 23;10(4):558-563. Epub 2019 Jan 23.

Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Viale delle Scienze, 27/A, 43124 Parma, Italy.

We have recently discovered a family of 2,6-diaminopurine derivatives acting as DENV inhibitors by targeting an allosteric pocket on the thumb of the viral NS5 polymerase. Although the following target-based optimization allowed conversion of the hits into broad-spectrum DENV/ZIKV inhibitors, no improvement of the antiviral potency was reached. Herein, we applied a phenotypic scaffold-morphing approach to explore additional biologically relevant chemical space around the original hits by converting the flat purine derivatives into more complex chemotypes characterized by a higher degree of saturation. Read More

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http://dx.doi.org/10.1021/acsmedchemlett.8b00583DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466831PMC

Human antibody response to Zika targets type-specific quaternary structure epitopes.

JCI Insight 2019 Apr 18;4(8). Epub 2019 Apr 18.

Department of Microbiology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

The recent Zika virus (ZIKV) epidemic in the Americas has revealed rare but serious manifestations of infection. ZIKV has emerged in regions endemic for dengue virus (DENV), a closely related mosquito-borne flavivirus. Cross-reactive antibodies confound studies of ZIKV epidemiology and pathogenesis. Read More

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https://insight.jci.org/articles/view/124588
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http://dx.doi.org/10.1172/jci.insight.124588DOI Listing
April 2019
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Larvicidal activity of Ocimum campechianum, Ocotea quixos and Piper aduncum essential oils against Aedes aegypti.

Parasite 2019 17;26:23. Epub 2019 Apr 17.

Department of Infectious Diseases, National Institute of Health (Istituto Superiore di Sanità, ISS), V.le Regina Elena 299, 00161 Rome, Italy.

Aedes aegypti, the main arbovirus vector of the Yellow fever, Dengue, Chikungunya and Zika viruses, is widely distributed in tropical and subtropical areas throughout the world. Preventive control efforts have been implemented worldwide aimed at reducing its impact on human health. The recent reduction of chemicals available for vector control due to their negative impact on the environment and human health and the increase in mosquito resistance to insecticides have driven the research community to identify and evaluate sustainable alternatives to synthetic insecticides. Read More

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http://dx.doi.org/10.1051/parasite/2019024DOI Listing
April 2019
2 Reads

A Direct from Blood/Plasma Reverse Transcription-Polymerase Chain Reaction for Dengue Virus Detection in Point-of-Care Settings.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Canada.

Infection with dengue virus (DENV) is widespread across tropical regions and can result in severe disease. Early diagnosis is important both for patient management and to differentiate infections that present with similar symptoms, such as malaria, chikungunya, and Zika. Rapid diagnostic tests that are used presently for point-of-care detection of DENV antigens lack the sensitivity of molecular diagnostics that detect viral RNA. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0138DOI Listing

A Prospective Study on the Impact and Out-of-Pocket Costs of Dengue Illness in International Travelers.

Am J Trop Med Hyg 2019 Apr 15. Epub 2019 Apr 15.

Department of Disease Control, London School of Hygiene and Tropical Medicine, London, United Kingdom.

Although the costs of dengue illness to patients and households have been extensively studied in endemic populations, international travelers have not been the focus of costing studies. As globalization and human travel activities intensify, travelers are increasingly at risk for emerging and reemerging infectious diseases, such as dengue. This exploratory study aims to investigate the impact and out-of-pocket costs of dengue illness among travelers. Read More

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http://dx.doi.org/10.4269/ajtmh.18-0780DOI Listing
April 2019
1 Read

A fatal hepatitis A virus with dengue fever co-infection.

Authors:
Gassem Gohal

IDCases 2019 12;15:e00522. Epub 2019 Mar 12.

Faculty of Medicine, Jazan University, Saudi Arabia.

We report the first pediatric fatal case of Hepatitis A virus (HAV) and dengue virus (DENV) co-infection. A 4-year-old boy who had a partial recovery of HAV infection but with subsequent DENV infection; the condition was complicated by acute fulminant hepatic failure, and death. The risk of DENV co-infection should be considered as cause of acute fulminant hepatic failure in pre-existing Hepatitis A infection. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22142509193004
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http://dx.doi.org/10.1016/j.idcr.2019.e00522DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441740PMC
March 2019
3 Reads

The Polyphenol-Rich Extract from an Endemic Medicinal Plant from Reunion Island, Inhibits the Early Stages of Dengue and Zika Virus Infection.

Int J Mol Sci 2019 Apr 15;20(8). Epub 2019 Apr 15.

Université de la Réunion, INSERM U1187, CNRS UMR 9192, IRD UMR 249, Unité Mixte Processus Infectieux en Milieu Insulaire Tropical, Plateforme Technologique CYROI, Sainte Clotilde, 97490 La Réunion, France.

The recent emergence and re-emergence of viral infections transmitted by vectors, such as the Zika virus (ZIKV) and Dengue virus (DENV), is a cause for international concern. These highly pathogenic arboviruses represent a serious health burden in tropical and subtropical areas of the world. Despite the high morbidity and mortality associated with these viral infections, antiviral therapies are missing. Read More

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http://dx.doi.org/10.3390/ijms20081860DOI Listing

Use of age-stage structural models to seek optimal Wolbachia-infected male mosquito releases for mosquito-borne disease control.

J Theor Biol 2019 Apr 13. Epub 2019 Apr 13.

College of Mathematics and Information Sciences, Guangzhou University, Guangzhou, 510006, PRC; Center for Applied Mathematics, Guangzhou University, Guangzhou, 510006 China. Electronic address:

Due to the lack of vaccines and effective clinical cures, current methods to control mosquito-borne viral diseases such as dengue and Zika are primarily targeting to eradicate the major mosquito vectors. However, traditional means, including larval source reduction and applications of insecticides etc, are not sufficient to keep vector population density below the epidemic risk threshold. An innovative and operational strategy is to release Wolbachia-infected male mosquitoes into wild areas to sterilize wild female mosquitoes by cytoplasmic incompatibility. Read More

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http://dx.doi.org/10.1016/j.jtbi.2019.04.010DOI Listing
April 2019
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Characterization of Bacterial Communities in Breeding Waters of Anopheles darlingi in Manaus in the Amazon Basin Malaria-Endemic Area.

Microb Ecol 2019 Apr 15. Epub 2019 Apr 15.

Department of Cell and Molecular Biology, Microbiology, Uppsala University, P.O. Box 596, 751 24, Uppsala, Sweden.

The microbiota in mosquito breeding waters can affect ovipositing mosquitoes, have effects on larval development, and can modify adult mosquito-gut bacterial composition. This, in turn, can affect transmission of human pathogens such as malaria parasites. Here, we explore the microbiota of four breeding sites for Anopheles darlingi, the most important malaria vector in Latin America. Read More

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http://dx.doi.org/10.1007/s00248-019-01369-9DOI Listing
April 2019
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Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.

Nat Microbiol 2019 Apr 15. Epub 2019 Apr 15.

UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC, USA.

Current models of cell-intrinsic immunity to RNA viruses centre on virus-triggered inducible antiviral responses initiated by RIG-I-like receptors or Toll-like receptors that sense pathogen-associated molecular patterns, and signal downstream through interferon regulatory factors (IRFs), transcription factors that induce synthesis of type I and type III interferons. RNA viruses have evolved sophisticated strategies to disrupt these signalling pathways and evade elimination by cells, attesting to their importance. Less attention has been paid to how IRFs maintain basal levels of protection against viruses. Read More

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http://dx.doi.org/10.1038/s41564-019-0425-6DOI Listing
April 2019
2 Reads

Essential Role of Visfatin in Lipopolysaccharide and Colon Ascendens Stent Peritonitis-Induced Acute Lung Injury.

Int J Mol Sci 2019 Apr 4;20(7). Epub 2019 Apr 4.

Translational Research Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

Acute lung injury (ALI) is a life-threatening syndrome characterized by acute and severe hypoxemic respiratory failure. Visfatin, which is known as an obesity-related cytokine with pro-inflammatory activities, plays a role in regulation of inflammatory cytokines. The mechanisms of ALI remain unclear in critically ill patients. Read More

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http://dx.doi.org/10.3390/ijms20071678DOI Listing
April 2019
2 Reads

A Stillborn Multiple Organs' Investigation from a Maternal DENV-4 Infection: Histopathological and Inflammatory Mediators Characterization.

Viruses 2019 Apr 2;11(4). Epub 2019 Apr 2.

Laboratório Interdisciplinar de Pesquisas Médicas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz/FIOCRUZ, Rio de Janeiro 21040-900, Brazil.

Dengue virus (DENV) is an emerging virus involved in outbreaks in Brazil. The association between the virus and vertical transmission, with disorders in the placenta, has raised a worldwide concern. On the 29th gestational week, a pregnant woman presented severe complications due to a DENV infection leading to maternal and fetus death. Read More

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http://dx.doi.org/10.3390/v11040319DOI Listing

Anti-Herpetic, Anti-Dengue and Antineoplastic Activities of Simple and Heterocycle-Fused Derivatives of Terpenyl-1,4-Naphthoquinone and 1,4-Anthraquinone.

Molecules 2019 Apr 2;24(7). Epub 2019 Apr 2.

Departamento de Ciencias Farmacéuticas, Área de Química Farmacéutica, Facultad de Farmacia, CIETUS, IBSAL. Campus Miguel de Unamuno, University of Salamanca, 37007-Salamanca, Spain.

Quinones are secondary metabolites of higher plants associated with many biological activities, including antiviral effects and cytotoxicity. In this study, the anti-herpetic and anti-dengue evaluation of 27 terpenyl-1,4-naphthoquinone (NQ), 1,4-anthraquinone (AQ) and heterocycle-fused quinone (HetQ) derivatives was done in vitro against Human Herpesvirus (HHV) type 1 and 2, and Dengue virus serotype 2 (DENV-2). The cytotoxicity on HeLa and Jurkat tumor cell lines was also tested. Read More

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http://dx.doi.org/10.3390/molecules24071279DOI Listing

Dengue Vaccine Booster in Healthy Adolescents and Adults in Latin America: Evaluation 4-5 Years After a Primary 3-Dose Schedule.

Pediatr Infect Dis J 2019 May;38(5):e90-e95

Clinical Sciences Sanofi Pasteur, Swiftwater, PA.

Background: The tetravalent dengue vaccine (CYD-TDV, Dengvaxia, Sanofi Pasteur) demonstrated efficacy in 2 previous phase III trials conducted in endemic countries. Neutralizing antibodies (NAbs) elicited by 3 doses of this vaccine have been associated with efficacy. Long-term follow-up data has shown that NAb immune responses tend to wane over time, after the third dose. Read More

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http://dx.doi.org/10.1097/INF.0000000000002286DOI Listing

Prevalence of kdr mutations and insecticide susceptibility among natural population of Aedes aegypti in West Bengal.

PLoS One 2019 15;14(4):e0215541. Epub 2019 Apr 15.

Department of Microbiology, Calcutta School of Tropical Medicine, Kolkata, West Bengal, India.

Background: Aedes albopictus and Aedes aegypti are the major vectors of arboviral diseases. As effective vaccines are not available for most of the arboviral diseases, vector control by using insecticides play the key role to reduce the disease transmission. The emergence and spread of resistance to different classes of insecticides by the vectors is a major obstacle to control the disease transmission. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215541PLOS
April 2019
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Low population Japanese encephalitis virus (JEV) seroprevalence in Udayapur district, Nepal, three years after a JE vaccination programme: A case for further catch up campaigns?

PLoS Negl Trop Dis 2019 Apr 15;13(4):e0007269. Epub 2019 Apr 15.

Institute of Infection and Global Health and National Institute for Health Research Health Protection Research Unit in Emerging and Zoonotic Infections, University of Liverpool, United Kingdom.

The live attenuated Japanese encephalitis (JE) vaccine SA14-14-2 has been used in Nepal for catch-up campaigns and is now included in the routine immunisation schedule. Previous studies have shown good vaccine efficacy after one dose in districts with a high incidence of JE. The first well-documented dengue outbreak occurred in Nepal in 2006 with ongoing cases now thought to be secondary to migration from India. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007269DOI Listing
April 2019
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A combination of incidence data and mobility proxies from social media predicts the intra-urban spread of dengue in Yogyakarta, Indonesia.

PLoS Negl Trop Dis 2019 Apr 15;13(4):e0007298. Epub 2019 Apr 15.

Department of Public Health and Clinical Medicine, Section of Sustainable Health, Umeå University, Umeå, Sweden.

Only a few studies have investigated the potential of using geotagged social media data for predicting the patterns of spatio-temporal spread of vector-borne diseases. We herein demonstrated the role of human mobility in the intra-urban spread of dengue by weighting local incidence data with geo-tagged Twitter data as a proxy for human mobility across 45 neighborhoods in Yogyakarta city, Indonesia. To estimate the dengue virus importation pressure in each study neighborhood monthly, we developed an algorithm to estimate a dynamic mobility-weighted incidence index (MI), which quantifies the level of exposure to virus importation in any given neighborhood. Read More

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http://dx.doi.org/10.1371/journal.pntd.0007298DOI Listing

Aedes aegypti HPX8C modulates immune responses against viral infection.

PLoS Negl Trop Dis 2019 Apr 15;13(4):e0007287. Epub 2019 Apr 15.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.

Mosquitoes act as vectors of numerous pathogens that cause human diseases. Dengue virus (DENV) transmitted by mosquito, Aedes aegypti, is responsible for dengue fever epidemics worldwide with a serious impact on human health. Currently, disease control mainly relies on vector targeted intervention strategies. Read More

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http://dx.plos.org/10.1371/journal.pntd.0007287
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http://dx.doi.org/10.1371/journal.pntd.0007287DOI Listing
April 2019
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Infectious Disease Threats in the Twenty-First Century: Strengthening the Global Response.

Front Immunol 2019 28;10:549. Epub 2019 Mar 28.

Department of Global Health and Population, Harvard T. H. Chan School of Public Health, Boston, MA, United States.

The world has developed an elaborate global health system as a bulwark against known and unknown infectious disease threats. The system consists of various formal and informal networks of organizations that serve different stakeholders; have varying goals, modalities, resources, and accountability; operate at different regional levels (i.e. Read More

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https://www.frontiersin.org/article/10.3389/fimmu.2019.00549
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http://dx.doi.org/10.3389/fimmu.2019.00549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447676PMC
March 2019
2 Reads

Pathways Exploited by Flaviviruses to Counteract the Blood-Brain Barrier and Invade the Central Nervous System.

Front Microbiol 2019 28;10:525. Epub 2019 Mar 28.

Departamento de Virologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.

Human infection by different flaviviruses may cause severe neurologic syndromes, through pathogenic mechanisms that are still largely unknown. Japanese encephalitis virus (JEV), West Nile virus (WNV), Zika virus (ZIKV), yellow fever virus (YFV), dengue virus (DENV), and tick-borne encephalitis virus (TBEV) are believed to reach the central nervous system by a hematogenous route, upon crossing the blood-brain barrier. Although the disruption of BBB during flavivirus infection has been largely evidenced in experimental models, the relevance of BBB breakdown for virus entering the brain was not completely elucidated. Read More

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https://www.frontiersin.org/article/10.3389/fmicb.2019.00525
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http://dx.doi.org/10.3389/fmicb.2019.00525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6447710PMC
March 2019
2 Reads

Evaluation of loop-mediated isothermal amplification assay for detection of scrub typhus in patients with acute febrile illness presenting to a Tertiary Care Center in Puducherry, India.

J Lab Physicians 2019 Jan-Mar;11(1):82-86

Department of Microbiology, Pondicherry Institute of Medical Sciences, Puducherry, India.

Purpose: Scrub typhus an acute febrile illness has diverse clinical manifestations, which overlap with other febrile illnesses. Due to this reason, it is misdiagnosed, leading to inappropriate treatment, sometimes resulting in fatality. Thus, accurate diagnosis of scrub typhus is important for appropriate treatment. Read More

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http://dx.doi.org/10.4103/JLP.JLP_148_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437831PMC
April 2019
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Can rapid dengue diagnostic kits be trusted? A comparative study of commercially available rapid kits for serodiagnosis of dengue fever.

J Lab Physicians 2019 Jan-Mar;11(1):63-67

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, Uttar Pradesh, India.

Background: Dengue virus infection is an important emerging disease of the tropical and subtropical regions and is mainly diagnosed by serological detection of NS1 antigen and IgM antidengue antibodies. Since enzyme-linked immunosorbent assay (ELISA) facilities are not easily available at most diagnostic centers, so most of them use various commercially available rapid diagnostic tests (RDTs) kits.

Aims And Objectives: This study was designed to access the diagnostic accuracy of four commercially available and widely used RDTs for serodiagnosis of dengue virus infection in Indian laboratories. Read More

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http://dx.doi.org/10.4103/JLP.JLP_140_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437816PMC

Serological evidence of human leptospirosis in patients with acute undifferentiated febrile illness from Uttarakhand, India: A pilot study.

J Lab Physicians 2019 Jan-Mar;11(1):11-16

Department of Microbiology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India.

Context: To the best of our knowledge, there are no reports of serological evidence of human leptospirosis from Uttarakhand state in India.

Aims: The aim of this study was to screen for serological evidence of leptospirosis in patients with acute undifferentiated febrile illness at a tertiary care teaching hospital in Uttarakhand.

Settings And Design: A pilot study was conducted from March to November 2017. Read More

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http://dx.doi.org/10.4103/JLP.JLP_121_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437824PMC
April 2019
2 Reads

Arboviral diseases and malaria in Australia, 2014–15: Annual report of the National Arbovirus and Malaria Advisory Committee

Commun Dis Intell (2018) 2019 Apr 15;43. Epub 2019 Apr 15.

Royal Darwin Hospital Northern Territory; Menzies School of Health Research, Darwin, Northern Territory

This report describes the epidemiology of mosquito-borne diseases of public health importance in Australia during the 2014–15 season (1 July 2014 to 30 June 2015) and includes data from human notifications, sentinel chicken, vector and virus surveillance programs. The National Notifiable Diseases Surveillance System received notifications for 12,849 cases of disease transmitted by mosquitoes during the 2014–15 season. The Australasian alphaviruses Barmah Forest virus and Ross River virus accounted for 83% (n=10,723) of notifications. Read More

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April 2019
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Anticancer activity of grassy Hystrix brachyura bezoar and its mechanisms of action: An in vitro and in vivo based study.

Biomed Pharmacother 2019 Apr 10;114:108841. Epub 2019 Apr 10.

Department of Biomedical Science, Kuliyyah of Allied Health Sciences, International Islamic University Malaysia, 25200, Kuantan, Pahang, Malaysia. Electronic address:

Porcupine bezoar (PB) is a calcified undigested material generally found in porcupine's (Hystrix brachyura) gastrointestinal tract. The bezoar is traditionally used in South East Asia and Europe for the treatment of cancer, poisoning, dengue, typhoid, etc. However, limited scientific studies have been performed to verify its anticancer potential to substantiate its traditional claims in the treatment of cancers. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108841DOI Listing
April 2019
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Emerging trend of dengue and chikungunya fever in Pakistan; Lesson learnt from the past?

Travel Med Infect Dis 2019 Apr 11. Epub 2019 Apr 11.

Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad, Pakistan. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14778939183038
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http://dx.doi.org/10.1016/j.tmaid.2019.04.005DOI Listing
April 2019
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Dengue fever in Saudi Arabia: A review of environmental and population factors impacting emergence and spread.

Travel Med Infect Dis 2019 Apr 9. Epub 2019 Apr 9.

Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, 98195, USA; Department of Global Health, University of Washington, School of Public Health, Seattle, WA, 98195, USA; Department of Environmental and Occupational Health Sciences, University of Washington, Box 357234 1959 NE Pacific Street, Seattle, WA, 98195, USA; Department of Emergency Medicine, School of Medicine, University of Washington, Seattle, WA, 98195, USA. Electronic address:

Dengue fever (DF) is the most important mosquito-transmitted viral disease causing a large economic and disease burden in many parts of the world. Most DF research focuses on Latin America and Asia, where burdens are highest. There is a critical need for studies in other regions where DF is an important public health problem but less well-characterized and can differ, such as the Middle East. Read More

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http://dx.doi.org/10.1016/j.tmaid.2019.04.006DOI Listing
April 2019
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Target and non-target botanical pesticides effect of Trichodesma indicum (Linn) R. Br. and their chemical derivatives against the dengue vector, Aedes aegypti L.

Environ Sci Pollut Res Int 2019 Apr 12. Epub 2019 Apr 12.

Division of Biopesticides and Environmental Toxicology, Sri Paramakalyani Centre for Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi, Tirunelveli, Tamil Nadu, 627 412, India.

The effects of crude ethanol derived leaf extract Trichodesma indicum (Linn) (Ex-Ti) and their chief derivatives were accessed on the survival and development of the dengue mosquito Ae. aegypti also their non-toxic activity against mosquito predator. T. Read More

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http://dx.doi.org/10.1007/s11356-019-04870-3DOI Listing
April 2019
2.828 Impact Factor

Impact of Temperature Variant on Survival of Aedes albopictus Skuse (Diptera: Culicidae): Implications on Thermotolerance and Acclimation.

Neotrop Entomol 2019 Apr 11. Epub 2019 Apr 11.

Epidemiology and Community Medicine, ICMR-Regional Medical Research Centre, Ministry of Health & Family Welfare, Govt of India, Post Bag No. 13, Dollygunj, Port Blair, Andaman Nicobar Islands, 744 101, India.

Aedes albopictus (Skuse 1894) is prevalent in the urban/peri-urban Port Blair, posing a public health threat, during past outbreaks of chikungunya (2006) and dengue (2010). Despite its vector potential, information on the biology is scanty. Therefore, impact of temperature on survival of immature stages, under laboratory conditions, was studied on F population of Andamans. Read More

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http://dx.doi.org/10.1007/s13744-019-00680-xDOI Listing

Neem oil increases the persistence of the entomopathogenic fungus Metarhizium anisopliae for the control of Aedes aegypti (Diptera: Culicidae) larvae.

Parasit Vectors 2019 Apr 11;12(1):163. Epub 2019 Apr 11.

Department of Entomology and Plant Pathology, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, CEP 28013-602, Brazil.

Background: The entomopathogenic fungus Metarhizium anisopliae is a candidate for the integrated management of the disease vector mosquito Aedes aegypti. Metarhizium anisopliae is pathogenic and virulent against Ae. aegypti larvae; however, its half-life is short without employing adjuvants. Read More

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http://dx.doi.org/10.1186/s13071-019-3415-xDOI Listing