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J Med Virol 2022 May 20. Epub 2022 May 20.

Laboratório de Morfologia e Morfogênese Viral.

Dengue fever, caused by the dengue virus (DENV-1, -2, -3 and -4), affects millions of people in the tropical and subtropical regions worldwide. Severe dengue is correlated with high viraemia and cytokine storm, such as high levels of transforming growth factor-β1 (TGF-β1) in the patient's serum. Here, the TGF-β1 signaling was investigated in the context of in vitro viral clearance. Read More

Environ Sci Pollut Res Int 2022 May 21. Epub 2022 May 21.

CPMU, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore, India, 560065.

Aedes aegypti is the main vector of yellow fever, chikungunya, Zika, and dengue worldwide and is managed by using chemical insecticides. Though effective, their indiscriminate use brings in associated problems on safety to non-target and the environment. This supports the use of plant-based essential oil (EO) formulations as they are safe to use with limited effect on non-target organisms. Read More

PLoS Negl Trop Dis 2022 May 20;16(5):e0010360. Epub 2022 May 20.

State Key Laboratory of Infectious Disease Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Background: Dengue fever has been a significant public health challenge in China. This will be particularly important in the context of global warming, frequent international travels, and urbanization with increasing city size and population movement. In order to design relevant prevention and control strategies and allocate health resources reasonably, this study evaluated the economic burden of dengue fever in China in 2019. Read More

Med Vet Entomol 2022 May 20. Epub 2022 May 20.

Department of Biological and Medical Sciences, Oxford Brookes University, Headington, Oxford, UK.

In Lao People's Democratic Republic, Aedes aegypti (Linnaeus 1762) and Aedes albopictus (Skuse 1894) mosquitoes (Diptera: Culicidae) are vectors of arboviral diseases such as dengue. As the treatment for these diseases is limited, control of the vectors with the use of pyrethroid insecticides is still essential. However, mutations in the voltage-gated sodium channel (vgsc) gene giving rise to pyrethroid resistance are threatening vector control programs. Read More

Trans R Soc Trop Med Hyg 2022 May 18. Epub 2022 May 18.

Lao-Oxford-Mahosot Hospital-Wellcome Trust-Research Unit, Microbiology Laboratory, Mahosot Hospital, Vientiane, Lao PDR.

Background: The mainstay of diagnostic confirmation of acute Japanese encephalitis (JE) involves detection of anti-JE virus (JEV) immunoglobulin M (IgM) by enzyme-linked immunosorbent assay (ELISA). Limitations in the specificity of this test are increasingly apparent with the introduction of JEV vaccinations and the endemicity of other cross-reactive flaviviruses. Virus neutralization testing (VNT) is considered the gold standard, but it is challenging to implement and interpret. Read More

J Water Process Eng 2021 Apr 29;40:101947. Epub 2021 Jan 29.

Laboratory for Research on Advanced Processes for Water Treatment, Instituto de Ingeniería, Unidad Académica Juriquilla, Universidad Nacional Autónoma de México, Blvd. Juriquilla 3001, Queretaro, CP 76230, Mexico.

Currently, SARS-CoV-2 has been detected in the influent of wastewater treatment plants (WWTP), pumping stations, manholes, sewer networks and sludge of WWTP and facilities of countries as France, Spain, Italy, Netherlands, United States, Australia, Ecuador, Brazil and Japan. Although this virus has been detected in the wastewater streams, there is no robust method for its detection and quantification in wastewater. This review compiled and analyzed the virus concentration approaches applied to detect the SARS-CoV-2, besides to provide insights about the methodology for viral concentration, limit of detection, occurrence, persistence, and perspectives post-COVID-19 related with the implications of the virus presence in wastewater. Read More

Ecol Evol 2022 May 13;12(5):e8896. Epub 2022 May 13.

Department of Ecology and Evolutionary Biology Yale University New Haven Connecticut USA.

The mosquito first invaded the Americas about 500 years ago and today is a widely distributed invasive species and the primary vector for viruses causing dengue, chikungunya, Zika, and yellow fever. Here, we test the hypothesis that the North American colonization by . occurred via a series of founder events. Read More

Virus Evol 2022 18;8(1):veac027. Epub 2022 Apr 18.

UMR "Unité des Virus Emergents", Aix-Marseille Université-IRD 190-Inserm 1207-IHU Méditerranée Infection, Marseille, France.

Intraspecies (homologous) phylogenetic incongruence, or 'tree conflict' between different loci within the same genome of mosquito-borne flaviviruses (MBFV), was first identified in dengue virus (DENV) and subsequently in Japanese encephalitis virus (JEV), St Louis encephalitis virus, and Zika virus (ZIKV). Recently, the first evidence of phylogenetic incongruence between interspecific members of the MBFV was reported in ZIKV and its close relative, Spondweni virus. Uniquely, these hybrid proteomes were derived from four incongruent trees involving an -associated DENV node (1 tree) and three different -associated flavivirus nodes (3 trees). Read More

Parasit Vectors 2022 May 19;15(1):173. Epub 2022 May 19.

Department of Pathogen Biology and Immunology, Jiangsu Key Laboratory of Immunity and Metabolism, Xuzhou Medical University, Xuzhou, China.

Background: Dengue is prevalent worldwide and is transmitted by Aedes mosquitoes. Temperature is a strong driver of dengue transmission. However, little is known about the underlying mechanisms. Read More

Zhonghua Liu Xing Bing Xue Za Zhi 2022 May;43(5):716-721

Department of Virology and Immunology, Guangzhou Center for Disease Control and Prevention, Guangzhou 510440, China.

To assess the incidence of dengue fever and E gene evolution of dengue virus in Guangzhou in 2020 and understand the local epidemiological characteristics of dengue fever and spreading of dengue virus. The information of dengue fever cases in Guangzhou in 2020 was collected from Notifiable Infectious Disease System of Chinese Center for Disease Control and Prevention Information System. Serum samples from the cases were detected by real-time PCR. Read More

J Am Mosq Control Assoc 2022 Jun;38(2):118-122

The diseases transmitted by Aedes mosquitoes, such as dengue, chikungunya, yellow fever, and Zika, are ever-increasing. Rapid and unplanned urbanization adversely impacts various endemic species such as ants and facilitates the breeding of Aedes mosquitoes. We have observed the predatory potential of ants over Aedes eggs in urban breeding habitats, and their impact on Aedes mosquito breeding was determined by a field experiment that mimicked the natural breeding habitats. Read More

J Am Mosq Control Assoc 2022 Jun;38(2):113-117

Most residences in the United States Virgin Islands (USVI) rely on household rainwater-catchment systems and subterranean cisterns for long-term water storage that may provide suitable habitats for mosquitoes of public health relevance. We conducted a household cistern survey (n = 164) on the islands of St. Croix, St. Read More

JCI Insight 2022 May 19. Epub 2022 May 19.

Johns Hopkins University School of Medicine, Baltimore, United States of America.

The Aedes aegypti mosquito transmits both dengue (DENV) and Zika (ZIKV) viruses. Individuals in endemic areas are at risk for infection with both viruses as well as repeated DENV infection. In the presence of anti-DENV antibodies, outcomes of secondary DENV infection range from mild to life-threatening. Read More

PLoS Negl Trop Dis 2022 May 19;16(5):e0010398. Epub 2022 May 19.

Department of Tropical Pediatrics, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Most cases of dengue virus infection are mild, but severe cases can be fatal. Therefore, identification of factors associated with dengue severity is essential to improve patient outcomes and reduce mortality. The objective of this study was to assess associations between nutritional status and dengue severity among Thai children and adolescents. Read More

Appl Biochem Biotechnol 2022 May 19. Epub 2022 May 19.

Department of Chemistry, Vinayaka Mission's Kirupananda Variyar Arts and Science College, Vinayaka Missions Research Foundation (Deemed to be University), Tamilnadu, 636308, Salem, India.

Dengue fever is a rapidly spreading infection that affects people all over the tropics and subtropics, posing a significant public health threat. The brown seaweed Stoechospermum marginatum was found all over the world, from South Africa (Indian Ocean) to Australia (Pacific Ocean), among other places. In India, it is only available along the coast of the Bay of Bengal, which is a small region. Read More

Infect Dis Ther 2022 May 19. Epub 2022 May 19.

Center for Health and the Global Environment (CHanGE), University of Washington, Seattle, WA, 98195, USA.

Climate change is adversely affecting the burden of infectious disease throughout the world, which is a health security threat. Climate-sensitive infectious disease includes vector-borne diseases such as malaria, whose transmission potential is expected to increase because of enhanced climatic suitability for the mosquito vector in Asia, sub-Saharan Africa, and South America. Climatic suitability for the mosquitoes that can carry dengue, Zika, and chikungunya is also likely to increase, facilitating further increases in the geographic range and longer transmission seasons, and raising concern for expansion of these diseases into temperate zones, particularly under higher greenhouse gas emission scenarios. Read More

Sci Rep 2022 May 18;12(1):8333. Epub 2022 May 18.

Facultad de Medicina, Universidad de Antioquia, 050010, Medellín, Colombia.

Dengue is a growing global threat in some of the world's most rapidly growing landscapes. Research shows that urbanization and human movement affect the spatial dynamics and magnitude of dengue outbreaks; however, precise effects of urban growth on dengue are not well understood because of a lack of sufficiently fine-scaled data. We analyzed nine years of address-level dengue case data in Medellin, Colombia during a period of public transit expansion. Read More

Am J Epidemiol 2022 May 18. Epub 2022 May 18.

Institute of Mathematics and Computer Science, University of São Paulo, Avenida Trabalhador São Carlense 400, São Carlos 13566-590, São Paulo, Brazil.

Dengue is a serious public health concern in Brazil and globally. In the absence of a universal vaccine or specific treatments, prevention relies on vector control and disease surveillance. Accurate and early forecasts can help reduce the spread of the disease. Read More

Acta Trop 2022 May 15:106500. Epub 2022 May 15.

Post-graduate program in Parasitary Biology in the Amazon, Center of Biological and Health Sciences, State of Pará University, Belém, 66095-662, Brazil; Evandro Chagas Institute - IEC/SVS/MS, Department of Arbovirology and Hemorrhagic Fevers, Ananindeua, 67030-000, Brazil. Electronic address:

The genus Aedes (Diptera: Culicidae) includes species of great epidemiological relevance, particularly involved in transmission cycles of leading arboviruses in the Brazilian Amazon region, such as the Zika virus (ZIKV), Dengue virus (DENV), Yellow fever virus (YFV), and Chikungunya virus (CHIKV). We report here the first putatively complete sequencing of the mitochondrial genomes of Brazilian populations of the species Aedes albopictus, Aedes scapularis and Aedes serratus. The sequences obtained showed an average length of 14,947 bp, comprising 37 functional subunits, typical in animal mitochondria (13 PCGs, 22 tRNA, and 2 rRNA). Read More

PLoS Negl Trop Dis 2022 May 18;16(5):e0010255. Epub 2022 May 18.

Instituto Nacional de Investigação em Saúde (INIS), Ministry of Health, Luanda, Angola.

Background: Transmission patterns and genetic diversity of dengue virus (DENV) circulating in Africa remains poorly understood. Circulation of the DENV serotype 1 (DENV1) in Angola was detected in 2013, while DENV serotype 2 (DENV2) was detected for the first time in 2018. Here, we report results from molecular and genomic investigations conducted at the Ministry of Health national reference laboratory (INIS) in Angola on suspected dengue cases detected between January 2017 and February 2019. Read More

Heliyon 2022 May 13;8(5):e09416. Epub 2022 May 13.

Sun Pharmaceutical Industries Limited, India.

Background And Aim: Dengue a worldwide concern for public health has no effective vaccine or drug available for its prevention or treatment. There are billions of people who are at risk of contracting the dengue virus (DENV) infections with only anti-mosquito strategies to combat this disease. Based on the reports, particularly in vitro studies and small animal studies showing anti-viral activity of aqueous extract of (AQCH), studies were conducted on AQCH tablets as a potential for the treatment of dengue and COVID-19 infections. Read More

BMJ Case Rep 2022 May 17;15(5). Epub 2022 May 17.

Internal Medicine, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India

J Virol 2022 May 17:e0043522. Epub 2022 May 17.

Center of Infectious Diseases and Pathogen Biology, Institute of Virology and AIDS Research, Key Laboratory of Organ Regeneration and Transplantation of The Ministry of Education, The First Hospital of Jilin University, Changchun, China.

Platelet factor 4 (PF4) or the CXC chemokine CXCL4 is the most abundant protein within the α-granules of platelets. Previous studies found that PF4 regulates infections of several viruses, including HIV-1, H1N1, hepatitis C virus (HCV), and dengue virus. Here, we show that PF4 is an inhibitor of enterovirus A71 (EV71) and coxsackievirus A16 (CA16) infections. Read More

J Med Virol 2022 May 16. Epub 2022 May 16.

ndian Council of Medical Research-National Institute of Cholera and Enteric Diseases, P-33, Scheme XM, CIT Road, Beliaghata, Kolkata, 700010, West Bengal, India.

Dengue fever is a self-limiting, acute febrile illness caused by an arbovirus. This infection may be asymptomatic or symptomatic with its potential life-threatening form as DHF/DSS. Severe dengue cases occur typically in children due to overproduction of pro-inflammatory and anti-inflammatory cytokines (called cytokines storm) as well as increased microvascular permeability in them. Read More

BMC Health Serv Res 2022 May 16;22(1):657. Epub 2022 May 16.

Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.

Background: The Southern Province of Sri Lanka is endemic with dengue, with frequent outbreaks and occurrence of severe disease. However, the economic burden of dengue is poorly quantified. Therefore, we conducted a cost analysis to assess the direct and indirect costs associated with hospitalized patients with dengue to households and to the public healthcare system. Read More

Sci Rep 2022 May 16;12(1):8060. Epub 2022 May 16.

Tata Institute for Genetics and Society, New InStem Building, GKVK Post, Bellary Road, Bangalore, 560065, India.

Mosquitoes are globally distributed and adapted to a broad range of environmental conditions. As obligatory hosts of many infectious pathogens, mosquito abundance and distribution are primarily determined by the presence and quality of larval habitats. To understand the dynamics and productivity of larval habitats in changing island environments, we conducted a four-month mosquito survey across ten inhabited islands in the Lakshadweep archipelago. Read More

Sci Rep 2022 May 16;12(1):8109. Epub 2022 May 16.

ICMR-National Institute of Medical Statistics, Indian Council of Medical Research, Ansari Nagar, New Delhi, 110 029, India.

Dengue fever is a mosquito-borne infection with a rising trend, expected to increase further with the rise in global temperature. The study aimed to use the environmental and dengue data 2015-2018 to examine the seasonal variation and establish a probabilistic model of environmental predictors of dengue using the generalized linear model (GLM). In Delhi, dengue cases started emerging in the monsoon season, peaked in the post-monsoon, and thereafter, declined in early winter. Read More

J Pediatr 2022 May 13. Epub 2022 May 13.

RCMI Center for Research Resources, Ponce Health Sciences University, PO Box 7004, Ponce, Puerto Rico, PR 00732-7004; Clinical Psychology Program, Ponce Health Sciences University, PO Box 7004, Ponce, Puerto Rico, PR 00732-7004.

Objective: To describe anthropometric, sensory, and neurodevelopmental outcomes of Zika virus exposed children from birth to 36 months.

Study Design: The cohort includes 114 children born to mothers with confirmed and probable ZIKV pregnancy infection, from 2016-2017. Children attending study visits from May 2017 through February 2020 underwent physical/neurologic, sensory examinations, and neurodevelopmental assessments with Bayley Scales of Infant and Toddler Development (BSID-III) and Ages and Stages Questionnaires (ASQ-3). Read More

Front Cell Infect Microbiol 2022 28;12:821061. Epub 2022 Apr 28.

Virus-Host Interactions Lab, Infectious Disease Biology, Institute of Life Sciences, Bhubaneswar, India.

The Dengue virus (DENV) and Chikungunya virus (CHIKV) are the arboviruses that pose a threat to global public health. Coinfection and antibody-dependent enhancement are major areas of concern during DENV and CHIKV infections, which can alter the clinical severity. Acute hepatic illness is a common manifestation and major sign of disease severity upon infection with either dengue or chikungunya. Read More

Rev Bras Farmacogn 2022 May 7:1-11. Epub 2022 May 7.

Department of Botany, Sri Kaliswari College (Autonomous), Sivakasi, Tamil Nadu 626123 India.

Dengue fever has become one of the deadliest infectious diseases and requires the development of effective antiviral therapies. It is caused by members of the Flaviviridae family, which also cause various infections in humans, including dengue fever, tick-borne encephalitis, West Nile fever, and yellow fever. In addition, since 2019, dengue-endemic regions have been grappling with the public health and socio-economic impact of the ongoing coronavirus disease 19. Read More