Search our Database of Scientific Publications and Authors

I’m looking for a

    18729 results match your criteria Dengue

    1 OF 375

    Prolonged Zika virus viremia in a patient with Guillain-Barré syndrome in Trinidad and Tobago.
    Rev Panam Salud Publica 2018 Feb 19;41:e136. Epub 2018 Feb 19.
    Caribbean Public Health Agency (CARPHA), Port of Spain, Trinidad and Tobago. Send correspondence to Gabriel Gonzalez-Escobar at
    An emerging mosquito-borne flavivirus, Zika virus (ZIKV) is a significant public health concern because of the syndromes associated with the infection. In addition, ZIKV is considered a major problem due to large-scale spread of the disease and the possible clinical complications for the central nervous system, especially Guillain-Barré syndrome (GBS) and microcephaly. Since the introduction of ZIKV in the Caribbean, molecular detection of the viral RNA has been utilized as a more specific and sensitive approach to demonstrating acute infection. Read More

    Potential occurrence of Zika from subtropical to temperate Argentina considering the basic reproduction number (R0).
    Rev Panam Salud Publica 2018 Feb 19;41:e120. Epub 2018 Feb 19.
    CONICET, Instituto Nacional de Medicina Tropical, Argentina.
    Objective: To assess the potential occurrence of Zika transmission throughout Argentina by the mosquito Aedes aegypti considering the basic reproduction number (R0).

    Methods: A model originally developed for dengue was adapted for Zika. R0 was estimated as a function of seven parameters, three of them were considered temperature-dependent. Read More

    [Infoxication in health. Health information overload on the Internet and the risk of important information becoming invisible].
    Rev Panam Salud Publica 2018 Feb 19;41:e115. Epub 2018 Feb 19.
    Organización Panamericana de la Salud, Unidad de Información y Análisis de Salud, Departamento de Enfermedades Transmisibles, Washington, DC, Estados Unidos de América,
    Objective: The objectives of this study were to: 1) raise awareness of the volume of quality health information on the Internet; 2) explore perceptions of information professionals with regard to the use of qualified sources for health decision-making; and 3) make recommendations that facilitate strengthening health worker capacities and institutional competencies related to digital literacy.

    Methods: A non-experimental, descriptive cross-sectional study was conducted with a non-probability sample of 32 information professionals from nine countries. Internet information was compiled on the volume of content in Internet tools, social networks, and health information sources. Read More

    Liver involvement in dengue viral infections.
    Rev Med Virol 2018 Feb 21. Epub 2018 Feb 21.
    Institute of Immunity and Transplantation, Royal Free Hospital and University College London, London, UK.
    Dengue fever is the commonest viral haemorrhagic fever worldwide and is a leading cause of morbidity and mortality in the tropics. Dengue viral infections are frequently associated with varying degrees of liver injury. Liver injury is more severe in dengue haemorrhagic fever or severe dengue. Read More

    Metformin Use and Severe Dengue in Diabetic Adults.
    Sci Rep 2018 Feb 20;8(1):3344. Epub 2018 Feb 20.
    Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore, Singapore.
    Diabetes mellitus is a risk factor for severe dengue in adults, but few studies have examined the association between metformin use and disease severity in dengue. In addition to its effect on glucose control, metformin has been associated with pleiotropic properties in preclinical studies. Using a cohort of laboratory-confirmed adult (≥21 years) dengue patients with diabetes mellitus admitted to Tan Tock Seng Hospital, we conducted a retrospective cohort study involving 131 (58. Read More

    Prospective forecasts of annual dengue hemorrhagic fever incidence in Thailand, 2010-2014.
    Proc Natl Acad Sci U S A 2018 Feb 20. Epub 2018 Feb 20.
    Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts, Amherst, MA 01003.
    Dengue hemorrhagic fever (DHF), a severe manifestation of dengue viral infection that can cause severe bleeding, organ impairment, and even death, affects between 15,000 and 105,000 people each year in Thailand. While all Thai provinces experience at least one DHF case most years, the distribution of cases shifts regionally from year to year. Accurately forecasting where DHF outbreaks occur before the dengue season could help public health officials prioritize public health activities. Read More

    Alterations of mitochondrial electron transport chain and oxidative stress induced by alkaloid-like α-aminonitriles on Aedes aegypti larvae.
    Pestic Biochem Physiol 2018 Jan 22;144:64-70. Epub 2017 Nov 22.
    Grupo de Investigaciones en Bioquímica y Microbiología (GIBIM), Escuela de Química, Universidad Industrial de Santander, Bucaramanga A.A. 678, Colombia. Electronic address:
    Aedes aegypti mosquitoes are responsible for dengue, chikungunya, and Zika virus transmission in tropical and subtropical areas around the world. Due to the absence of vaccines or antiviral drugs for human treatment, the majority of control strategies are targeted at Ae. aegypti elimination. Read More

    Effectiveness of a field trap barrier system for controlling Aedes albopictus: a "removal trapping" strategy.
    Parasit Vectors 2018 Feb 20;11(1):101. Epub 2018 Feb 20.
    MIVEGEC, UMR IRD224-CNRS5290-Université de Montpellier, Montpellier, France.
    Background: Aedes aegypti and Aedes albopictus are the main vectors for the transmission of several viral pathogens, in particular, dengue, Zika and chikungunya. In the absence of vaccines and treatment, control of Aedes mosquitoes is the only means of keeping these diseases in check. Aedes control is difficult, and it is, therefore, necessary to evaluate the efficacy of novel control methods, particularly those targeting adult and exophilic Ae. Read More

    Using adult Aedes aegypti females to predict areas at risk for dengue transmission: A spatial case-control study.
    Acta Trop 2018 Feb 17. Epub 2018 Feb 17.
    Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Avenida Doutor Arnaldo 715, São Paulo, SP, Brazil. Electronic address:
    Introduction: Traditional indices for measuring dengue fever risk in a given area are based on the immature forms of the vector (larvae and pupae surveys). However, this is inefficient because only adult female mosquitoes actually transmit the virus. Based on these assumptions, our objective was to evaluate the association between an entomological index obtained from adult mosquito traps and the occurrence of dengue in a hyperendemic area. Read More

    Seasonal Distribution and Container Preference Ratio of the Dengue Fever Vector (Aedes aegypti, Diptera: Culicidae) in Rawalpindi, Pakistan.
    J Med Entomol 2018 Feb 15. Epub 2018 Feb 15.
    Punjab Health Department Rawalpindi, Pakistan.
    Aedes aegypti (L.) and Aedes albopictus (Skuse) are known vectors of dengue, chikungunya, and other pathogens; however, their ecology and role in virus transmission has not been well studied in Pakistan. Here, we report on an intensive survey of potential breeding sites of Ae. Read More

    Characteristics and predictors for gastrointestinal hemorrhage among adult patients with dengue virus infection: Emphasizing the impact of existing comorbid disease(s).
    PLoS One 2018 20;13(2):e0192919. Epub 2018 Feb 20.
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
    Background: Gastrointestinal (GI) bleeding is a leading cause of death in dengue. This study aims to identify predictors for GI bleeding in adult dengue patients, emphasizing the impact of existing comorbid disease(s).

    Methods: Of 1300 adults with dengue virus infection, 175 (mean age, 56. Read More

    Host plant forensics and olfactory-based detection in Afro-tropical mosquito disease vectors.
    PLoS Negl Trop Dis 2018 Feb 20;12(2):e0006185. Epub 2018 Feb 20.
    International Centre of Insect Physiology and Ecology, Nairobi, Kenya.
    The global spread of vector-borne diseases remains a worrying public health threat, raising the need for development of new combat strategies for vector control. Knowledge of vector ecology can be exploited in this regard, including plant feeding; a critical resource that mosquitoes of both sexes rely on for survival and other metabolic processes. However, the identity of plant species mosquitoes feed on in nature remains largely unknown. Read More

    Aetiology of acute encephalitis syndrome in Uttar Pradesh, India from 2014 to 2016.
    J Vector Borne Dis 2017 Oct-Dec;54(4):311-316
    Department of Microbiology, King George's Medical University, Lucknow, India.
    Background & Objectives: It is imperative to know the aetiology of acute encephalitis syndrome (AES) for patient management and policy making. The present study was carried out to determine the prevalence of common aetiological agents of AES in Uttar Pradesh (UP) state of India.

    Methods: Serum and/or CSF samples were collected from AES patients admitted at Gandhi Memorial and Associated Hospital, King George's Medical University, Lucknow, a tertiary care centre, UP during 2014-16. Read More

    Improving vector-borne pathogen surveillance: A laboratory-based study exploring the potential to detect dengue virus and malaria parasites in mosquito saliva.
    J Vector Borne Dis 2017 Oct-Dec;54(4):301-310
    IVCC, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
    Background & Objectives: Vector-borne pathogen surveillance programmes typically rely on the collection of large numbers of potential vectors followed by screening protocols focused on detecting pathogens in the arthropods. These processes are laborious, time consuming, expensive, and require screening of large numbers of samples. To streamline the surveillance process, increase sample throughput, and improve cost-effectiveness, a method to detect dengue virus and malaria parasites (Plasmodium falciparum) by leveraging the sugar-feeding behaviour of mosquitoes and their habit of expectorating infectious agents in their saliva during feeding was investigated in this study. Read More

    (Bigot) mosquito: An emerging threat to public health.
    J Vector Borne Dis 2017 Oct-Dec;54(4):295-300
    ICMR-National Institute of Virology, Microbial Containment Complex, Pune, India.
    Aedes vittatus (Bigot) mosquito is a voracious biter of humans and has a geographical distribution throughout tropical Asia, Africa and the Mediterranean region of Europe. It is predominantly a rock-hole breeder, though it can breed in diverse macro- and micro-habitats. The mosquito plays an important role in the maintenance and transmission of yellow fever (YFV), dengue (DENV), chikungunya (CHIKV) and Zika (ZIKV) viruses. Read More

    Seroprevalence of Dengue and Chikungunya Virus Antibodies, French Polynesia, 2014-2015.
    Emerg Infect Dis 2018 Mar;24(3):558-561
    We investigated dengue and chikungunya virus antibody seroprevalence in French Polynesia during 2014-2015. Dengue virus seroprevalence was ≈60% among schoolchildren and >83% among the general population; chikungunya virus seroprevalence was <3% before and 76% after Zika virus emergence (2013). Dengue virus herd immunity may affect Zika virus infection and pathogenesis. Read More

    Seroprevalence of Dengue Antibodies in Three Urban Settings in Yucatan, Mexico.
    Am J Trop Med Hyg 2018 Feb 19. Epub 2018 Feb 19.
    National Institute of Public Health, Cuernavaca, Mexico.
    Dengue transmission in Mexico has become a major public health problem. Few epidemiological studies have examined the seroprevalence of dengue in Mexico, and recent estimates are needed to better understand dengue transmission dynamics. We conducted a dengue seroprevalence survey among 1,668 individuals including all age groups in three urban settings in Yucatan, Mexico. Read More

    The desert wormwood (Artemisia herba-alba) - From Arabian folk medicine to a source of green and effective nanoinsecticides against mosquito vectors.
    J Photochem Photobiol B 2018 Feb 11;180:225-234. Epub 2018 Feb 11.
    Department of Agriculture, Food and Environment, University of Pisa, via del Borghetto 80, 56124 Pisa, Italy; The BioRobotics Institute, Scuola Superiore Sant'Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera, Pisa, Italy. Electronic address:
    The development of eco-friendly and effective insecticides is crucial for public health worldwide. Herein, we focused on the desert wormwood (Artemisia herba-alba), a plant widely used in Arabian traditional medicine, as a source of green nanoinsecticides against mosquito vectors, as well as growth inhibitors to be employed against microbial pathogens. Ag nanoparticles (AgNPs) fabricated with the A. Read More

    Assessing dengue transmission risk and a vector control intervention using entomological and immunological indices in Thailand: study protocol for a cluster-randomized controlled trial.
    Trials 2018 Feb 20;19(1):122. Epub 2018 Feb 20.
    MRC Tropical Epidemiology Group, London, UK.
    Background: Dengue fever is the most common and widespread mosquito-borne arboviral disease in the world. There is a compelling need for cost-effective approaches and practical tools that can reliably measure real-time dengue transmission dynamics that enable more accurate and useful predictions of incidence and outbreaks. Sensitive surveillance tools do not exist today, and only a small handful of new control strategies are available. Read More

    Community Engagement and Field Trials of Genetically Modified Insects and Animals.
    Hastings Cent Rep 2018 Jan;48(1):25-36
    New techniques for the genetic modification of organisms are creating new strategies for addressing persistent public health challenges. For example, the company Oxitec has conducted field trials internationally-and has attempted to conduct field trials in the United States-of a genetically modified mosquito that can be used to control dengue, Zika, and some other mosquito-borne diseases. In 2016, a report commissioned by the National Academies of Sciences, Engineering, and Medicine discussed the potential benefits and risks of another strategy, using gene drives. Read More

    A rapid point-of-care test for dengue virus-1 based on a lateral flow assay with a near-infrared fluorescent dye.
    J Immunol Methods 2018 Feb 15. Epub 2018 Feb 15.
    Medical University of PLA, Beijing, China; Center for Clinical Laboratory, 302 Hospital of PLA, Beijing, China. Electronic address:
    Dengue fever is caused by the dengue virus (DENV), and DENV1 is the prevalent epidemic serotype in south China. A new lateral flow assay (LFA) based on a near-infrared (NIR) fluorescent dye was developed to detect anti-DENV1 IgG antibodies. DyLight-800 was used as the marker conjugated to goat anti-human IgG antibodies, and recombinant dengue type 1 envelope protein was used as the capture protein on the test line. Read More

    Management of arthropod vector data - Social and ecological dynamics facing the One Health perspective.
    Acta Trop 2018 Feb 15. Epub 2018 Feb 15.
    Benjamin Franklin Institute of Technology, Boston, MA, United States.
    Emerging infectious diseases (EIDs) are spread by direct and/or indirect contacts between a pathogen or parasite and their hosts. Arthropod vectors have evolved as excellent bloodsuckers, providing an elegant transportation mode for a wide number of infectious agents. The nature of pathogen and parasite transfer and the models used to predict how a disease might spread are magnified in complexity when an arthropod vector is part of the disease cycle. Read More

    Crystal Structure of the Capsid Protein from Zika Virus.
    J Mol Biol 2018 Feb 15. Epub 2018 Feb 15.
    Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing, 100049, China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Center for Influenza Research and Early-warning (CASCIRE), Chinese Academy of Sciences, Beijing, 100101, China; Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, China; National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, China. Electronic address:
    Recently, Zika virus (ZIKV) emerged as a global public health concern, and is distinct from other flaviviruses in many aspects, e.g., causing transplacental infection, fetal abnormalities and vector-independent transmission through body fluids in humans. Read More

    Non-linear effects of mean temperature and relative humidity on dengue incidence in Guangzhou, China.
    Sci Total Environ 2018 Feb 14;628-629:766-771. Epub 2018 Feb 14.
    Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen University, Guangzhou, China; Center for Migrant Health Policy, Sun Yat-sen University, Guangzhou, China. Electronic address:
    Background: Dengue fever is an important infectious disease in Guangzhou, China; previous studies on the effects of weather factors on the incidence of dengue fever did not consider the linearity of the associations.

    Methods: This study evaluated the effects of daily mean temperature, relative humidity and rainfall on the incidence of dengue fever. A generalized additive model with splines smoothing function was performed to examine the effects of daily mean, minimum and maximum temperatures, relative humidity and rainfall on incidence of dengue fever during 2006-2014. Read More

    Botanical essential oils and uses as mosquitocides and repellents against dengue.
    Environ Int 2018 Feb 13;113:214-230. Epub 2018 Feb 13.
    United States Department of Agriculture, Agricultural Research Service, U.S. Horticultural Research Laboratory, 2001 South Rock Road, Fort Pierce, FL 34945, USA.
    Plants naturally produce bioactive compounds along with many secondary metabolites which serve as defensive chemical against herbivorers including insect pests. One group of these phytochemicals are the 'Essential Oils' (EO's), which possess an extensive range of biological activity especially insecticidal and insect repellents. This review provides a comprehensive viewpoint on potential modes of action of biosafety plant derived Essential Oils (EO's) along with their principal chemical derivatives against larvae and adult mosquito vectors of dengue virus. Read More

    Comparative immunogenicity of preparations of yeast-derived dengue oral vaccine candidate.
    Microb Cell Fact 2018 Feb 16;17(1):24. Epub 2018 Feb 16.
    Department of Molecular Biology, Department of Bioactive Material Sciences, Institute for Molecular Biology and Genetics, Chonbuk National University, Jeonju, Jeollabuk-do, 54896, Republic of Korea.
    Background: Dengue is listed as a neglected tropical disease by the Center for Disease Control and Preservation, as there are insufficient integrated surveillance strategies, no effective treatment, and limited licensed vaccines. Consisting of four genetically distinct serotypes, dengue virus (DENV) causes serious life-threatening infections due to its complexity. Antibody-dependent enhancement by pre-existing cross-reactive as well as homotypic antibodies further worsens the clinical symptoms of dengue. Read More

    Dengue infection in patients with febrile illness and its relationship to climate factors: A case study in the city of Jeddah, Saudi Arabia, for the period 2010-2014.
    Acta Trop 2018 Feb 13;181:105-111. Epub 2018 Feb 13.
    Special Infectious Agents Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah, Saudi Arabia; Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
    Dengue is an important global arboviral disease with expanding geographical range. It is a major public health concern in Western Saudi Arabia since its first detection in the city of Jeddah in 1994. In this retrospective study, we examined dengue incidence among febrile patients suspected for acute dengue infection at King Abdulaziz University Hospital, Jeddah from 2010 to 2014 and we tried to determine the effect of climate factors on dengue incidence in the city. Read More

    Dengue knowledge, attitudes and practices and their impact on community-based vector control in rural Cambodia.
    PLoS Negl Trop Dis 2018 Feb 16;12(2):e0006268. Epub 2018 Feb 16.
    Technical Department, Malaria Consortium, Phnom Penh, Cambodia.
    Background: Globally there are an estimated 390 million dengue infections per year, of which 96 million are clinically apparent. In Cambodia, estimates suggest as many as 185,850 cases annually. The World Health Organization global strategy for dengue prevention aims to reduce mortality rates by 50% and morbidity by 25% by 2020. Read More

    Environmental factors can influence dengue reported cases.
    Rev Assoc Med Bras (1992) 2017 Nov;63(11):957-961
    Faculdade de Medicina do ABC (FMABC), Santo André, SP, Brazil.
    Introduction: Global climate changes directly affect the natural environment and contribute to an increase in the transmission of diseases by vectors. Among these diseases, dengue is at the top of the list. The aim of our study was to understand the consequences of temporal variability of air temperature in the occurrence of dengue in an area comprising seven municipalities of the Greater São Paulo. Read More

    Entomological and epidemiological aspects of dengue epidemics in Fortaleza, Ceará, Brazil, 2001-2012.
    Epidemiol Serv Saude 2018 15;27(1):e201704414. Epub 2018 Feb 15.
    Programa de Pós-Graduação em Saúde Coletiva, Universidade Federal do Ceará, Fortaleza, CE, Brazil.
    Objective: to characterize the entomological and epidemiological aspects of dengue epidemics occurred in Fortaleza, Ceará, Brazil, from 2001 to 2012.

    Methods: descriptive study with data from the Information System for Notifiable Diseases (Sinan), Information System of Hospitalizations due to Yellow Fever and Dengue (2001-2009), National Program for Dengue Control (2010-2012), and Rapid Survey of Aedes aegypti Infestation Index, referring to the years in which the incidence of dengue was above 75%.

    Results: from 2001 to 2012, 194,446 cases of suspected dengue were notified; the epidemic years were 2001, 2006, 2008, 2011 and 2012; there was a progressive increase in the incidence of the disease (587. Read More

    Single-cell transcriptional dynamics of flavivirus infection.
    Elife 2018 Feb 16;7. Epub 2018 Feb 16.
    Department of Bioengineering, Stanford University, Stanford, United States.
    Dengue and Zika viral infections affect millions of people annually and can be complicated by hemorrhage or neurological manifestations, respectively. However, a thorough understanding of the host response to these viruses is lacking, partly because conventional approaches ignore heterogeneity in virus abundance across cells. We present viscRNA-Seq (virus-inclusive single cell RNA-Seq), an approach to probe the host transcriptome together with intracellular viral RNA at the single cell level. Read More

    Endemic and emerging acute virus infections in Indonesia: an overview of the past decade and implications for the future.
    Crit Rev Microbiol 2018 Feb 16:1-17. Epub 2018 Feb 16.
    a Department of Viroscience , Erasmus MC , Rotterdam , the Netherlands.
    Being the largest archipelago country in the world, with a tropical climate and a unique flora and fauna, Indonesia habitats one of the most diverse biome in the world. These characteristics make Indonesia a popular travel destination, with tourism numbers increasing yearly. These characteristics also facilitate the transmission of zoonosis and provide ideal living and breading circumstances for arthropods, known vectors for viral diseases. Read More

    Stem-Loop RNA Hairpins in Giant Viruses: Invading rRNA-Like Repeats and a Template Free RNA.
    Front Microbiol 2018 1;9:101. Epub 2018 Feb 1.
    Unité de Recherche sur les Maladies Infectieuses et Tropicales Emergentes, UMR MEPHI, Aix-Marseille Université, IRD, Assistance Publique-Hôpitaux de Marseille, Institut Hospitalo-Universitaire Méditerranée-Infection, Marseille, France.
    We examine the hypothesis thattemplate-free RNAs still form spontaneously, as they did at the origins of life, invade modern genomes, contribute new genetic material. Previously, analyses of RNA secondary structures suggested that some RNAs resembling ancestral (t)RNAs formed recently, other parasitic sequences cluster with rRNAs. Here positive control analyses of additional RNA secondary structures confirm ancestral andstatuses of RNA grouped according to secondary structure. Read More

    Multiplexed and portable nucleic acid detection platform with Cas13, Cas12a, and Csm6.
    Science 2018 Feb 15. Epub 2018 Feb 15.
    Broad Institute of MIT and Harvard Cambridge, MA 02142, USA.
    Rapid detection of nucleic acids is integral for clinical diagnostics and biotechnological applications. We recently developed a platform termed SHERLOCK (pecificigh Sensitivitynzymaticeporter Uning) that combines isothermal pre-amplification with Cas13 to detect single molecules of RNA or DNA. Through characterization of CRISPR enzymology and application development, we report here four advances integrated into SHERLOCKv2: 1) 4-channel single reaction multiplexing using orthogonal CRISPR enzymes; 2) quantitative measurement of input down to 2 aM; 3) 3. Read More

    Insertion of dengue E into lipid bilayers studied by neutron reflectivity and molecular dynamics simulations.
    Biochim Biophys Acta 2018 Feb 12. Epub 2018 Feb 12.
    Sandia National Laboratories, Albuquerque, NM, United States. Electronic address:
    The envelope (E) protein of Dengue virus rearranges to a trimeric hairpin to mediate fusion of the viral and target membranes, which is essential for infectivity. Insertion of E into the target membrane serves to anchor E and possibly also to disrupt local order within the membrane. Both aspects are likely to be affected by the depth of insertion, orientation of the trimer with respect to the membrane normal, and the interactions that form between trimer and membrane. Read More

    Inhibitor Bound Dengue NS2B-NS3pro Reveals Multiple Dynamic Binding Modes.
    Biochemistry 2018 Feb 21. Epub 2018 Feb 21.
    Nexomics Biosciences, Inc. , 1200 Florence Columbus Road, Bordentown, New Jersey 08505, United States.
    Dengue virus poses a significant global health threat as the source of increasingly deleterious dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. As no specific antiviral treatment exists for dengue infection, considerable effort is being applied to discover therapies and drugs for maintenance and prevention of these afflictions. The virus is primarily transmitted by mosquitoes, and infection occurs following viral endocytosis by host cells. Read More

    Analysis of cluster-randomized test-negative designs: cluster-level methods.
    Biostatistics 2018 Feb 12. Epub 2018 Feb 12.
    World Mosquito Program, Institute of Vector Borne Disease, Monash University, Level 1, 12 Innovation Walk, Clayton, Victoria 3800, Australia.
    Intervention trials of vector control methods often require community level randomization with appropriate inferential methods. For many interventions, the possibility of confounding due to the effects of health-care seeking behavior on disease ascertainment remains a concern. The test-negative design, a variant of the case-control method, was introduced to mitigate this issue in the assessment of the efficacy of influenza vaccination (measured at an individual level) on influenza infection. Read More

    Dynamic remodeling of lipids coincides with dengue virus replication in the midgut of Aedes aegypti mosquitoes.
    PLoS Pathog 2018 Feb 15;14(2):e1006853. Epub 2018 Feb 15.
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America.
    We describe the first comprehensive analysis of the midgut metabolome of Aedes aegypti, the primary mosquito vector for arboviruses such as dengue, Zika, chikungunya and yellow fever viruses. Transmission of these viruses depends on their ability to infect, replicate and disseminate from several tissues in the mosquito vector. The metabolic environments within these tissues play crucial roles in these processes. Read More

    Joint ancestry and association test indicate two distinct pathogenic pathways involved in classical dengue fever and dengue shock syndrome.
    PLoS Negl Trop Dis 2018 Feb 15;12(2):e0006202. Epub 2018 Feb 15.
    Functional Genetics of Infectious Diseases Unit, Institut Pasteur, Paris, France.
    Ethnic diversity has been long considered as one of the factors explaining why the severe forms of dengue are more prevalent in Southeast Asia than anywhere else. Here we take advantage of the admixed profile of Southeast Asians to perform coupled association-admixture analyses in Thai cohorts. For dengue shock syndrome (DSS), the significant haplotypes are located in genes coding for phospholipase C members (PLCB4 added to previously reported PLCE1), related to inflammation of blood vessels. Read More

    The correlation of TNF alpha levels with the lipid profile of dengue patients.
    J Med Virol 2018 Feb 15. Epub 2018 Feb 15.
    Hospital General de Culiacán, "Bernardo J Gastélum", Culiacán, Sinaloa, México.
    Immunological factors, such as cytokines, have been proposed as a cause of changes in the lipid profile of dengue patients. We studied whether serum lipid levels and serum TNF-α levels are associated in a group of dengue patients from an endemic region in the northwest of Mexico. We found statistically important differences in the serum lipid profile and the TNF-α levels of dengue patients compared with the control group, were observed. Read More

    Current and future distribution of Aedes aegypti and Aedes albopictus (Diptera: Culicidae) in WHO Eastern Mediterranean Region.
    Int J Health Geogr 2018 Feb 14;17(1). Epub 2018 Feb 14.
    Regional Office for the Eastern Mediterranean, World Health Organisation, Cairo, Egypt.
    Background: Aedes-borne diseases as dengue, zika, chikungunya and yellow fever are an emerging problem worldwide, being transmitted by Aedes aegypti and Aedes albopictus. Lack of up to date information about the distribution of Aedes species hampers surveillance and control. Global databases have been compiled but these did not capture data in the WHO Eastern Mediterranean Region (EMR), and any models built using these datasets fail to identify highly suitable areas where one or both species may occur. Read More

    Highlights for Dengue Immunopathogenesis: Antibody-Dependent Enhancement, Cytokine Storm, and Beyond.
    J Interferon Cytokine Res 2018 Feb;38(2):69-80
    1 Laboratório de Virologia Molecular, Instituto Carlos Chagas , ICC/Fiocruz/PR, Curitiba, Brazil .
    Infection with dengue virus (DENV) can lead to a wide spectrum of clinical presentations, ranging from asymptomatic infection to death. It is estimated that the disease manifests only in 90 million cases out of the total 390 million yearly infections. Even though research has not yet elucidated which are the precise pathophysiological mechanisms that trigger severe forms of dengue, the infection elicits a critical immune response significant for dengue pathogenesis development. Read More

    Targeted Elimination of Peroxisomes During Viral Infection: Lessons from HIV and Other Viruses.
    DNA Cell Biol 2018 Feb 14. Epub 2018 Feb 14.
    1 Department of Medical Microbiology and Immunology, University of Alberta , Edmonton, Canada .
    Peroxisomes are membrane-bound organelles that are best known for their roles in lipid metabolism. Mounting evidence indicates that they are also important nodes for antiviral signaling. While research over the past few decades has revealed effective viral strategies to block antiviral signalling pathways from the plasma membrane, mitochondria and/or the nucleus, until recently, very little was known about how viruses interfere with peroxisome-based antiviral signaling. Read More

    An unsettling explanation for the failure of skatole-baited ovitraps to capture Culex mosquitoes.
    Insect Sci 2018 Feb 14. Epub 2018 Feb 14.
    Department of Molecular and Cellular Biology, University of California-Davis, Davis, CA, 95616, USA.
    Culex mosquitoes are primarily found in temperate and tropical regions worldwide where they play a crucial role as main vectors of filarial worms and arboviruses. In Recife, a northeast city in Brazil, high densities of Culex quinquefasciatus are often found in association with human populated areas. In marked contrast to another part of the city, field tests conducted in the neighborhood of Sítio dos Pintos showed that trapping of mosquitoes in skatole-baited ovitraps did not differ significantly from captures in control (water) traps. Read More

    Validation of genotype imputation in Southeast Asian populations and the effect of single nucleotide polymorphism annotation on imputation outcome.
    BMC Med Genet 2018 Feb 13;19(1):23. Epub 2018 Feb 13.
    Division of Bioinformatics and Data Management for Research, Department of Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Background: Imputation involves the inference of untyped single nucleotide polymorphisms (SNPs) in genome-wide association studies. The haplotypic reference of choice for imputation in Southeast Asian populations is unclear. Moreover, the influence of SNP annotation on imputation results has not been examined. Read More

    Brain Imaging in Cases with Positive Serology for Dengue with Neurologic Symptoms: A Clinicoradiologic Correlation.
    AJNR Am J Neuroradiol 2018 Feb 8. Epub 2018 Feb 8.
    From the Departments of Radiology (H.A.V., P.M., S.M.)
    Background And Purpose: Dengue is a common arboviral disease, which uncommonly involves the brain. There has been a recent surge in dengue cases and dengue-related deaths in tropical countries. The aim of this study was to describe brain imaging findings in patients with dengue infection having neurologic symptoms. Read More

    Validation of POCKIT™ Dengue Virus Reagent Set for Rapid Detection of Dengue Virus in Human Serum on a Field-Deployable PCR System.
    J Clin Microbiol 2018 Feb 7. Epub 2018 Feb 7.
    GeneReach Biotechnology, Taichung, Taiwan.
    Dengue virus (DENV) infection, a mosquito-borne disease, is a major public health problem in tropical countries. Point-of-care DENV detection with good sensitivity and specificity enables timely early diagnosis of DENV infection, facilitating effective disease management and control particularly at regions of low resource. POCKIT™ Dengue Virus Reagent Set (GeneReach Biotech), a reverse transcription-insulated isothermal PCR (RT-iiPCR), is available to detect all four serotypes of DENV on the field-deployable POCKIT™ system, which is ready for on-site applications. Read More

    Are Perceived Prevalences of Infection Also Biased and How? Lessons from Large Epidemics of Mosquito-Borne Diseases in Tropical Regions.
    Med Decis Making 2018 Feb 1:272989X17750845. Epub 2018 Feb 1.
    EHESP Rennes, Université Sorbonne Paris Cité, France (JR).
    Background: Although people are likely to underestimate the frequencies of risks to health from common diseases and overestimate those from rare diseases, we still do not know much about reasons for this systematic bias, which is also referred to as "primary bias" in the literature. In this study, we take advantage of a series of large epidemics of mosquito-borne diseases to examine the accuracy of judgments of risk frequencies. In this aim, we assessed the perceived v. Read More

    Tick-Borne Encephalitis Virus Vaccine-Induced Human Antibodies Mediate Negligible Enhancement of Zika Virus Infectionand in a Mouse Model.
    mSphere 2018 Jan-Feb;3(1). Epub 2018 Feb 7.
    Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
    Recent reports in the scientific literature have suggested that anti-dengue virus (DENV) and anti-West Nile virus (WNV) immunity exacerbates Zika virus (ZIKV) pathogenesisandin mouse models. Large populations of immune individuals exist for a related flavivirus (tick-borne encephalitis virus [TBEV]), due to large-scale vaccination campaigns and endemic circulation throughout most of northern Europe and the southern Russian Federation. As a result, the question of whether anti-TBEV immunity can affect Zika virus pathogenesis is a pertinent one. Read More

    1 OF 375