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    A predictive score for hypotension in patients with confirmed dengue fever in Cayenne Hospital, French Guiana.
    Trans R Soc Trop Med Hyg 2016 Dec;110(12):705-713
    Equipe d'Accueil EA3593 Ecosystèmes Amazoniens et Pathologie Tropicale, Université de Guyane, 97300 Cayenne, French Guiana.
    Background: Identifying patients at risk of developing severe dengue is challenging. The objective of the present study was to determine the incidence of hypotension and its predictive factors during the Dengue 2 epidemic in 2013.

    Methods: In 2013, a longitudinal study was performed using data from all confirmed cases of dengue seen in Cayenne General Hospital. Read More

    Household costs of hospitalized dengue illness in semi-rural Thailand.
    PLoS Negl Trop Dis 2017 Sep 22;11(9):e0005961. Epub 2017 Sep 22.
    Division of Social Science, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
    Background: Dengue-related illness is a leading cause of hospitalization and death in Thailand and other Southeast Asian countries, imposing a major economic burden on households, health systems, and governments. This study aims to assess the economic impact of hospitalized dengue cases on households in Chachoengsao province in eastern Thailand.

    Methods: We conducted a prospective cost-of-illness study of hospitalized pediatric and adult dengue patients at three public hospitals. Read More

    Analysis of the Optimal Vaccination Age for Dengue in Brazil with a Tetravalent Dengue Vaccine.
    Math Biosci 2017 Sep 18. Epub 2017 Sep 18.
    Department of Mathematics and Statistics, University of Strathclyde, Glasgow G1 1XH, U.K. Electronic address:
    In this paper we study a mathematical model to analyse the optimal vaccination age against Dengue in Brazil. Data from Brazil are used to estimate the basic reproduction numbers for each of the four Dengue serotypes and then the optimal vaccination age is calculated using a method due to Hethcote [1]. The vaccine has different efficacies against each serotype. Read More

    The dengue preface to endemic in mainland China: the historical largest outbreak by Aedes albopictus in Guangzhou, 2014.
    Infect Dis Poverty 2017 Sep 22;6(1):148. Epub 2017 Sep 22.
    Guangzhou Center for Disease Control and Prevention, Guangzhou, 510440, People's Republic of China.
    Background: Dengue was regarded as a mild epidemic in mainland China transmitted by Aedes albopictus. However, the 2014 record-breaking outbreak in Guangzhou could change the situation. In order to provide an early warning of epidemic trends and provide evidence for prevention and control strategies, we seek to characterize the 2014 outbreak through application of detailed cases and entomological data, as well as phylogenetic analysis of viral envelope (E) gene. Read More

    Isolation and identification of Xenorhabdus and Photorhabdus bacteria associated with entomopathogenic nematodes and their larvicidal activity against Aedes aegypti.
    Parasit Vectors 2017 Sep 21;10(1):440. Epub 2017 Sep 21.
    Department of Microbiology and Parasitology, Faculty of Medical Science, Naresuan University, Phitsanulok, 65000, Thailand.
    Background: Aedes aegypti is a potential vector of West Nile, Japanese encephalitis, chikungunya, dengue and Zika viruses. Alternative control measurements of the vector are needed to overcome the problems of environmental contamination and chemical resistance. Xenorhabdus and Photorhabdus are symbionts in the intestine of entomopathogenic nematodes (EPNs) Steinernema spp. Read More

    Early Detection for Dengue Using Local Indicator of Spatial Association (LISA) Analysis.
    Diseases 2016 Mar 29;4(2). Epub 2016 Mar 29.
    Grupo Biología y Control de Enfermedades Infecciosas-BCEI, Universidad de Antioquia, Calle 70 No. 52-21, Medellin 050010, Colombia.
    Dengue is a viral disease caused by a flavivirus that is transmitted by mosquitoes of the genus Aedes. There is currently no specific treatment or commercial vaccine for its control and prevention; therefore, mosquito population control is the only alternative for preventing the occurrence of dengue. For this reason, entomological surveillance is recommended by World Health Organization (WHO) to measure dengue risk in endemic areas; however, several works have shown that the current methodology (aedic indices) is not sufficient for predicting dengue. Read More

    Preparation of Mosquito Salivary Gland Extract and Intradermal Inoculation of Mice.
    Bio Protoc 2014 Jul;7(14)
    Wadsworth Center, New York State Department of Health, Albany, New York, USA.
    Mosquito-transmitted pathogens are among the leading causes of severe disease and death in humans. Components within the saliva of mosquito vectors facilitate blood feeding, modulate host responses, and allow efficient transmission of pathogens, such as Dengue, Zika, yellow fever, West Nile, Japanese encephalitis, and chikungunya viruses, as well as Plasmodium parasites, among others. Here, we describe standardized methods to assess the impact of mosquito-derived factors on immune responses and pathogenesis in mouse models of infection. Read More

    Genetic Profiling and Comorbidities of Zika Infection.
    J Infect Dis 2017 Sep;216(6):703-712
    Computer Laboratory, University of Cambridge,United Kingdom.
    Background: The difficulty in distinguishing infection by Zika virus (ZIKV) from other flaviviruses is a global health concern, particularly given the high risk of neurologic complications (including Guillain-Barré syndrome [GBS]) with ZIKV infection.

    Methods: We developed quantitative frameworks to compare and explore infectome, diseasome, and comorbidity of ZIKV infections. We analyzed gene expression microarray and RNA-Seq data from ZIKV, West Nile fever (WNF), chikungunya, dengue, yellow fever, Japanese encephalitis virus, GBS, and control datasets. Read More

    A novel immunization approach for dengue infection based on conserved T cell epitopes formulated in calcium phosphate nanoparticles.
    Hum Vaccin Immunother 2017 Sep 21. Epub 2017 Sep 21.
    a Immunotope, Inc. Doylestown , PA.
    Dengue virus (DV) is the etiologic agent of dengue fever, the most significant mosquito-borne viral disease in humans. Most DV vaccine approaches are focused on generating antibody mediated responses; one such DV vaccine is approved for use in humans but its efficacy is limited. While it is clear that T cell responses play important role in DV infection and subsequent disease manifestations, fewer studies are aimed at developing vaccines that induce robust T cells responses. Read More

    Response to Joob and Wiwanitkit re: "Genetic Polymorphisms of Tumor Necrosis Factor Alpha and Susceptibility to Dengue Virus Infection in a Mexican Population".
    Viral Immunol 2017 Sep 21. Epub 2017 Sep 21.
    3 Departamento de Infectómica y Patogénesis Molecular, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional (CINVESTAV-IPN) , Mexico City, Mexico .

    The Gut Commensal Microbiome of Drosophila melanogaster Is Modified by the Endosymbiont Wolbachia.
    mSphere 2017 Sep-Oct;2(5). Epub 2017 Sep 13.
    Department of Biology, Boston University, Boston, Massachusetts, USA.
    Endosymbiotic Wolbachia bacteria and the gut microbiome have independently been shown to affect several aspects of insect biology, including reproduction, development, life span, stem cell activity, and resistance to human pathogens, in insect vectors. This work shows that Wolbachia bacteria, which reside mainly in the fly germline, affect the microbial species present in the fly gut in a lab-reared strain. Drosophila melanogaster hosts two main genera of commensal bacteria-Acetobacter and Lactobacillus. Read More

    Zika virus congenital syndrome: experimental models and clinical aspects.
    J Venom Anim Toxins Incl Trop Dis 2017 15;23:41. Epub 2017 Sep 15.
    Neuroimmune Interactions Laboratory, Immunology Department - ICB IV, University of São Paulo (USP), Av. Prof. Lineu Prestes, 1730, Cidade Universitária, São Paulo, SP CEP 05508-900 Brazil.
    Viral infections have long been the cause of severe diseases to humans, increasing morbidity and mortality rates worldwide, either in rich or poor countries. Yellow fever virus, H1N1 virus, HIV, dengue virus, hepatitis B and C are well known threats to human health, being responsible for many million deaths annually, associated to a huge economic and social cost. In this context, a recently introduced flavivirus in South America, called Zika virus (ZIKV), led the WHO to declare in February 1st 2016 a warning on Public Health Emergency of International Concern (PHEIC). Read More

    Drug repurposing approaches to fight Dengue virus infection and related diseases.
    Front Biosci (Landmark Ed) 2018 Jan 1;23:997-1019. Epub 2018 Jan 1.
    Department of Food and Drug, University of Parma, Viale delle Scienze, 27/A, 43124 Parma, Italy,
    Dengue is a mosquito-borne viral disease caused by four antigenically distinct serotypes of Dengue Virus (DENV), namely DENV1-4 and is currently considered the most important arthropod-born viral disease in the world. An effective antiviral therapy to treat Dengue Virus infection is still missing and a number of replicative cycle inhibitors are currently under study. Considering the rapid spreading of DENV and the common timeframe required for bringing a new drug on the market, the repurposing of approved drugs used for different diseases to identify novel inhibitors of this pathogen represents an attractive approach for a rapid therapeutic intervention. Read More

    PERK Signal-Modulated Protein Translation Promotes the Survivability of Dengue 2 Virus-Infected Mosquito Cells and Extends Viral Replication.
    Viruses 2017 Sep 20;9(9). Epub 2017 Sep 20.
    Graduate Institute of Biomedical Sciences, Chang Gung University, Kwei-San, Tao-Yuan 33332, Taiwan.
    Survival of mosquitoes from dengue virus (DENV) infection is a prerequisite of viral transmission to the host. This study aimed to see how mosquito cells can survive the infection during prosperous replication of the virus. In C6/36 cells, global protein translation was shut down after infection by DENV type 2 (DENV2). Read More

    Spread of Chikungunya Virus East/Central/South African Genotype in Northeast Brazil.
    Emerg Infect Dis 2017 Oct;23(10):1742-1744
    We investigated an outbreak of exanthematous illness in Maceió by using molecular surveillance; 76% of samples tested positive for chikungunya virus. Genetic analysis of 23 newly generated genomes identified the East/Central/South African genotype, suggesting that this lineage has persisted since mid-2014 in Brazil and may spread in the Americas and beyond. Read More

    Autochthonous Transmission of East/Central/South African Genotype Chikungunya Virus, Brazil.
    Emerg Infect Dis 2017 Oct;23(10):1737-1739
    We isolated East/Central/South African genotype chikungunya virus during the 2016 epidemic in Rio de Janeiro, Brazil. Genome sequencing revealed unique mutations in the nonstructural protein 4 (NSP4-A481D) and envelope protein 1 (E1-K211T). Moreover, all Brazil East/Central/South isolates shared the exclusive mutations E1-M407L and E2-A103T. Read More

    Dengue Virus 1 Outbreak in Buenos Aires, Argentina, 2016.
    Emerg Infect Dis 2017 Oct;23(10):1684-1685
    The largest outbreak of dengue in Buenos Aires, Argentina, occurred during 2016. Phylogenetic, phylodynamic, and phylogeographic analyses of 82 samples from dengue patients revealed co-circulation of 2 genotype V dengue virus lineages, suggesting that this virus has become endemic to the Buenos Aires metropolitan area. Read More

    Emerging arboviruses in Rio Grande do Sul, Brazil: Chikungunya and Zika outbreaks, 2014-2016.
    Rev Med Virol 2017 Sep 20. Epub 2017 Sep 20.
    Laboratório de Biologia Molecular, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, RS, Brazil.
    Questions Investigated: The recent emergence of arboviruses such as Chikungunya virus (CHIKV) and Zika virus (ZIKV) in Brazil has posed a threat to human health and to the country's economy. Outbreaks occur mainly in tropical areas; however, increasing number of cases have been observed in Rio Grande do Sul (RS), the Southernmost state; therefore, surveillance of these arboviruses is essential for public health measures.

    Design: In this study, we analyzed 1276 samples from patients with clinically suspected arboviral diseases between 2014 and 2016. Read More

    Meta-analysis of biomarkers for severe dengue infections.
    PeerJ 2017 15;5:e3589. Epub 2017 Sep 15.
    Department of Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia.
    Background: Dengue viral infection is an acute infection that has the potential to have severe complications as its major sequela. Currently, there is no routine laboratory biomarker with which to predict the severity of dengue infection or monitor the effectiveness of standard management. Hence, this meta-analysis compared biomarker levels between dengue fever (DF) and severe dengue infections (SDI) to identify potential biomarkers for SDI. Read More

    Effect of Rainfall for the Dynamical Transmission Model of the Dengue Disease in Thailand.
    Comput Math Methods Med 2017 8;2017:2541862. Epub 2017 Aug 8.
    Computational & Applied Science for Smart Innovation Cluster (CLASSIC), Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand.
    The SEIR (Susceptible-Exposed-Infected-Recovered) model is used to describe the transmission of dengue virus. The main contribution is determining the role of the rainfall in Thailand in the model. The transmission of dengue disease is assumed to depend on the nature of the rainfall in Thailand. Read More

    Potential Risk Areas of Aedes albopictus in South-Eastern Iran: A Vector of Dengue Fever, Zika, and Chikungunya.
    Front Microbiol 2017 5;8:1660. Epub 2017 Sep 5.
    Department of Medical Entomology and Vector Control, School of Public Health, Tehran University of Medical SciencesTehran, Iran.
    The possibility of the rapid and global spread of Zika, chikungunya, yellow fever, and dengue fever by Aedes albopictus is well documented and may be facilitated by changes in climate. To avert and manage health risks, climatic and topographic information can be used to model and forecast which areas may be most prone to the establishment of Ae. albopictus. Read More

    Analysis of Individuals from a Dengue-Endemic Region Helps Define the Footprint and Repertoire of Antibodies Targeting Dengue Virus 3 Type-Specific Epitopes.
    MBio 2017 Sep 19;8(5). Epub 2017 Sep 19.
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, USA
    The four dengue virus serotypes (DENV1 to 4) cause dengue, a major public health problem worldwide. Individuals exposed to primary DENV infections develop serotype-specific neutralizing antibodies, including strongly neutralizing antibodies targeting quaternary epitopes. To date, no studies have measured the levels and kinetics of serum antibodies directed to such epitopes among populations in regions where dengue is endemic. Read More

    Insecticide susceptibility of Aedes albopictus and Ae. aegypti from Brazil and the Swiss-Italian border region.
    Parasit Vectors 2017 Sep 19;10(1):431. Epub 2017 Sep 19.
    Department of Entomology, Instituto Aggeu Magalhães-FIOCRUZ, Recife 50740-465, Brazil.
    Background: Aedes aegypti and Ae. albopictus are two highly invasive mosquito species, both vectors of several viruses, including dengue, chikungunya and Zika. While Ae. Read More

    Community participation in mosquito breeding site control: an interdisciplinary mixed methods study in Curaçao.
    Parasit Vectors 2017 Sep 19;10(1):434. Epub 2017 Sep 19.
    Population Research Center, Faculty of Spatial Sciences, University of Groningen, Groningen, The Netherlands.
    Background: As the arboviral diseases dengue, chikungunya and Zika emerge in the Americas, so does the need for sustainable vector control policies. To successfully achieve mosquito control, joint efforts of both communities and governments are essential. This study investigates this important, but by-and-large neglected topic. Read More

    Emerging Roles of Heparanase in Viral Pathogenesis.
    Pathogens 2017 Sep 18;6(3). Epub 2017 Sep 18.
    Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
    Heparan sulfate (HS) is ubiquitously expressed on mammalian cells. It is a polysaccharide that binds growth factors, cytokines, and chemokines, and thereby controls several important physiological functions. Ironically, many human pathogens including viruses interact with it for adherence to host cells. Read More

    Clinical Spectrum of Chikungunya in Pakistan.
    Cureus 2017 Jul 6;9(7):e1430. Epub 2017 Jul 6.
    Accident & Emergency, Jinnah Sindh Medical University (SMC).
    Background Chikungunya fever is a pandemic disease caused by an arthropod-borne chikungunya virus (CHIKV). The virus spreads through mosquitoes. This mosquito induced viral illness is clinically suspected on symptoms from fever and severe polyarthralgia. Read More

    Clinical outcomes of prophylactic platelet transfusion in patients with dengue: A retrospective study of patients at a tertiary care hospital in Karachi.
    J Pak Med Assoc 2017 Sep;67(9):1374-1378
    Patel Hospital, Karachi.
    Objective: To determine the benefit of prophylactic platelet transfusion on clinical outcomes in patients with dengue fever.

    Methods: The retrospective cohort study was conducted at Patel Hospital, Karachi, and comprised record of patients fulfilling World Health Organisation's diagnostic criteria for dengue between 2009 and 2015. We excluded patients with known auto-immune thrombocytopenia, isolated infection with a pathogen other than dengue virus, drug-induced thrombocytopenia and patients requiring therapeutic transfusion. Read More

    Sero-epidemiology study of leptospirosis in febrile patients from Terai region of Nepal.
    BMC Infect Dis 2017 Sep 18;17(1):628. Epub 2017 Sep 18.
    Department of Health Services, Ministry of Health, Government of Nepal, Kathmandu, Nepal.
    Background: Leptospirosis is a re-emerging zoonotic disease caused by pathogenic strains of bacteria belonging to genus Leptospira whose symptoms can range from mild clinical manifestations to a severe life threatening illness. This disease may be under-recognized in resource poor settings like Nepal where many clinical laboratories lack appropriate equipment, technology and personnel for proper diagnosis.

    Methods: We used IgM ELISA to estimate the sero-prevalence of leptospirosis in a group of febrile patients in a western region of Nepal. Read More

    Pathogen inactivation of Dengue virus in red blood cells using amustaline and glutathione.
    Transfusion 2017 Sep 16. Epub 2017 Sep 16.
    Pôle de Recherche et de Veille sur les Maladies Infectieuses Émergentes, Institut Louis Malardé, Tahiti, Polynésie Française.
    Background: Dengue virus (DENV) is an arbovirus primarily transmitted through mosquito bite; however, DENV transfusion-transmitted infections (TTIs) have been reported and asymptomatic DENV RNA-positive blood donors have been identified in endemic countries. DENV is considered a high-risk pathogen for blood safety. One of the mitigation strategies to prevent arbovirus TTIs is pathogen inactivation. Read More

    Importation of travel-related infectious diseases is increasing in South Korea: An analysis of salmonellosis, shigellosis, malaria, and dengue surveillance data.
    Travel Med Infect Dis 2017 Sep 15. Epub 2017 Sep 15.
    Department of Epidemiology, School of Public Health, Seoul National University, Republic of Korea. Electronic address:
    Background: International travel has an important role in transmission of emerging infectious diseases. We described the imported infectious diseases in Korea from 2003 to 2012, and to analyze association of travels with the change in the incidences.

    Methods: We used National Notifiable Disease Surveillance System to investigate the incidence of salmonellosis, shigellosis, malaria, and dengue. Read More

    Incidence and risk factors for Dengue virus (DENV) infection in the first 2 years of life in a Brazilian prospective birth cohort.
    Epidemiol Infect 2017 Sep 18:1-9. Epub 2017 Sep 18.
    Aggeu Magalhães Research Center,Oswaldo Cruz Foundation,Recife,Brazil.
    This study assessed the incidence and risk factors for dengue virus (DENV) infection among children in a prospective birth cohort conducted in the city of Recife, a hyperendemic dengue area in Northeast Brazil. Healthy pregnant women (n = 415) residing in Recife who agreed to have their children followed were enrolled. Children were followed during their first 24 months of age (May/2011-June/2014), before the 2015 Zika virus outbreak. Read More

    Clinical, laboratory and virological data from suspected ZIKV patients in an endemic arbovirus area.
    J Clin Virol 2017 Sep 9;96:20-25. Epub 2017 Sep 9.
    Faculdade de Medicina de São José do Rio Preto (FAMERP), São José do Rio Preto, SP, Brazil. Electronic address:
    Background: The emergence of Zika virus (ZIKV) presents new challenges to both clinicians and public health authorities. Overlapping clinical features between the diseases caused by ZIKV, dengue (DENV) and chikungunya (CHIKV) and the lack of validated serological assays for ZIKV make accurate diagnosis difficult. Brazilian authorities largely rely on clinical and epidemiological data for the epidemiological and clinical classifications of most ZIKV cases. Read More

    Dengue fever. Clinical features of 567 consecutive patients admitted to a tertiary care center in Saudi Arabia.
    Saudi Med J 2017 Oct;38(10):1025-1033
    Department of Medicine, Dr. Soliman Fakeeh Hospital, Jeddah, Kingdom of Saudi Arabia. E-mail.
    Objectives: To delineate the clinical features and outcomes of dengue infection and to guide clinician of early diagnosis and identification of risks factors for dengue hemorrhagic fever. Methods: This study is a retrospective cross-sectional. Clinical records of 567 patients with a confirmed diagnosis of dengue infection, admitted to a single hospital in Jeddah, Saudi Arabia, between January 2010 and  June 2014 were reviewed. Read More

    KIR2DS2 recognizes conserved peptides derived from viral helicases in the context of HLA-C.
    Sci Immunol 2017 Sep;2(15)
    Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK.
    Killer cell immunoglobulin-like receptors (KIRs) are rapidly evolving species-specific natural killer (NK) cell receptors associated with protection against multiple different human viral infections. We report that the activating receptor KIR2DS2 directly recognizes viral peptides derived from conserved regions of flaviviral superfamily 2 RNA helicases in the context of major histocompatibility complex class I. We started by documenting that peptide LNPSVAATL from the hepatitis C virus (HCV) helicase binds HLA-C*0102, leading to NK cell activation through engagement of KIR2DS2. Read More

    Zika virus structural biology and progress in vaccine development.
    Biotechnol Adv 2017 Sep 12. Epub 2017 Sep 12.
    Institute of Biotechnology, National Tsing Hua University, Hsinchu, Taiwan; Department of Medical Science, National Tsing Hua University, Hsinchu, Taiwan. Electronic address:
    The growing number of zika virus (ZIKV) infections plus a 20-fold increase in neonatal microcephaly in newborns in Brazil have raised alarms in many countries regarding the threat to pregnant women. Instances of microcephaly and central nervous system malformations continue to increase in ZIKV outbreak regions. ZIKV is a small enveloped positive-strand RNA virus belonging to the Flavivirus genus of the Flaviviridae family. Read More

    The Work of US Public Health Service Officers in Puerto Rico, 1898-1919.
    P R Health Sci J 2017 Sep;36(3):130-139
    Academia Puertorriqueña de la Historia, San Juan, Puerto Rico; Assistant Professor, ad honorem, University of Puerto Rico Schools of Public Health and Medicine; Captain (Retired), Commissioned Corps of the US Public Health Service; a native of Puerto Rico, where he served much of his career. The content of this article does not necessarily represent the official views of the United States Public Health Service.
    The history of the US Public Health Service (PHS) is usually presented in terms of diseases or discoveries; this article examines twenty years' activity in one location. When the United States invaded Puerto Rico in 1898, the Marine Hospital Service (now PHS) took responsibility for foreign quarantine, inspection of immigrants, and medical care for merchant seamen. Its officers evaluated the sanitary conditions of port cities, helped reorganize local disease surveillance and control, and investigated endemic diseases (e. Read More

    Development of Peptide Vaccines in Dengue.
    Curr Pharm Des 2017 09 13. Epub 2017 Sep 13.
    Research Centre for Biomedical Sciences, Sunway University, Bandar Sunway, Subang Jaya, Selangor. Malaysia
    Dengue is one of the most important arboviral infection worldwide, infecting up to 390 million people and causing 25,000 deaths annually. Although a licensed dengue vaccine is available, it is not efficacious against dengue serotypes that infect people living in South East Asia, where dengue is an endemic disease. Hence, there is an urgent need to develop an efficient dengue vaccine for this region. Read More

    Quantification through TLC-Densitometric analysis, repellency and anticholinesterase activity of the homemade extract of Indian cloves.
    Biomed Chromatogr 2017 Sep 15. Epub 2017 Sep 15.
    Laboratory of Molecular Modeling Applied to the Chemical and Biological Defense, Military Institute of Engineering, Rio de Janeiro, Brazil.
    The rise of mosquito's transmitted diseases, like dengue, zika and chikungunya in Brazil in the last years has increased the concerns on protection against mosquito's bites. However, the prohibitive prices of the commercially available repellents for the majority of the Brazilian population, has provoked a search for cheaper solutions, like the use of the homemade ethanolic extract of Indian clove (Syzygium aromaticum L.) as repellent, which has been reported as quite efficient by the local press. Read More

    Acute Liver Failure in a Patient Travelling From Asia: The Other Face of the Coin of Infectious Disease.
    Gastroenterology Res 2017 Aug 31;10(4):268-270. Epub 2017 Aug 31.
    Liver Unit in Kings College Hospital, London, UK.
    We present a case of a 63-year-old male who had travelled from South India to United Kingdom (UK) visiting relatives. He had developed episodes of diarrhea, vomiting and fevers while travelling and on assessment in hospital, mild abdominal distension was noted with rapid deterioration to hypovolemic shock. Initial blood test showed a low platelet count with deranged liver function tests (LFTs). Read More

    Hirsutine, an Indole Alkaloid of Uncaria rhynchophylla, Inhibits Late Step in Dengue Virus Lifecycle.
    Front Microbiol 2017 30;8:1674. Epub 2017 Aug 30.
    Laboratory of Primate Model, Institute for Frontier Life and Medical Sciences, Kyoto UniversityKyoto, Japan.
    Dengue virus (DENV) is transmitted to humans by Aedes mosquitoes and is a public health issue worldwide. No antiviral drugs specific for treating dengue infection are currently available. To identify novel DENV inhibitors, we analyzed a library of 95 compounds and 120 extracts derived from crude drugs (herbal medicines). Read More

    Concurrent Infection with Plasmodium vivax and the Dengue and Chikungunya Viruses in a Paediatric Patient from New Delhi, India in 2016.
    Intervirology 2017 Sep 15. Epub 2017 Sep 15.
    Centre for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, New Delhi, India.
    Dengue and chikungunya fevers are transmitted by the common mosquito vector Aedes and malaria by Anopheles. Concurrent infections are reported due to co-circulation of these pathogens, especially in endemic regions. We report a rare case of triple infection with 3 arthropod-borne pathogens (Plasmodium vivax and the dengue and chikungunya viruses) in a 3-year-old child from New Delhi, India, in August 2016. Read More

    Intrahost Selection Pressures Drive Rapid Dengue Virus Microevolution in Acute Human Infections.
    Cell Host Microbe 2017 Sep;22(3):400-410.e5
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, 185 Li Ka Shing Center, 1951 Oxford Street, Berkeley, CA 94720-3370, USA. Electronic address:
    Dengue, caused by four dengue virus serotypes (DENV-1 to DENV-4), is a highly prevalent mosquito-borne viral disease in humans. Yet, selection pressures driving DENV microevolution within human hosts (intrahost) remain unknown. We employed a whole-genome segmented amplification approach coupled with deep sequencing to profile DENV-3 intrahost diversity in peripheral blood mononuclear cell (PBMC) and plasma samples from 77 dengue patients. Read More

    Drivers of Dengue Intrahost Evolution.
    Cell Host Microbe 2017 Sep;22(3):260-261
    Viral Populations and Pathogenesis Unit, Institut Pasteur, 75015 Paris, France; CNRS UMR 3569, 75015 Paris, France. Electronic address:
    RNA viruses circulate as rapidly evolving swarms of related variants, and their evolutionary dynamics within hosts may be key to understanding virus emergence. In this issue of Cell Host & Microbe, Parameswaran et al. (2017) combine next-generation sequencing and functional studies to characterize viral populations in acute dengue infections. Read More

    Chikungunya Virus-Induced Arthritis: Role of Host and Viral Factors in the Pathogenesis.
    Viral Immunol 2017 Sep 14. Epub 2017 Sep 14.
    Dengue/Chikungunya Group, ICMR-National Institute of Virology , Pune, India .
    Chikungunya virus (CHIKV), a member of Alphavirus genus, is responsible for chikungunya fever (CHIKF), which is characterized by the presence of fever, rash, myalgia, and arthralgia. Reemergence of CHIKV has become a significant public health concern in Asian and African countries and is newly emerging in the Middle East, Pacific, American, and European countries. Cytokines, innate (monocytes, natural killer cells) and adaptive immune response (role of B cells and T cells i. Read More

    Predicting the mortality in geriatric patients with dengue fever.
    Medicine (Baltimore) 2017 Sep;96(37):e7878
    aDepartment of Emergency Medicine bDepartment of Occupational Medicine, Chi-Mei Medical Center cDepartment of Biotechnology, Southern Taiwan University of Science and Technology dBachelor Program of Senior Service eDepartment of Leisure, Recreation, and Tourism Management, Southern Taiwan University of Science and Technology fDepartment of Medical Research, Chi-Mei Medical Center, Liouying gDepartment of Environmental and Occupational Health, College of Medicine, National Cheng Kung University hDepartment of Geriatrics and Gerontology, Chi-Mei Medical Center iDepartment of Emergency Medicine, Taipei Medical University, Taipei, Taiwan.
    Geriatric patients have high mortality for dengue fever (DF); however, there is no adequate method to predict mortality in geriatric patients. Therefore, we conducted this study to develop a tool in an attempt to address this issue.We conducted a retrospective case-control study in a tertiary medical center during the DF outbreak in Taiwan in 2015. Read More

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