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    The immunopathology of dengue and Zika virus infections.
    Curr Opin Immunol 2017 Jul 21;48:1-6. Epub 2017 Jul 21.
    Department of Medicine, Imperial College London, London, United Kingdom. Electronic address:
    A large proportion of the world's population live in areas with dengue virus (DENV) transmission resulting in tens of millions of symptomatic dengue cases each year. Serious complications following DENV infection occur more frequently in those suffering from a second or subsequent infection implicating virus-specific immunity as having a role in pathogenesis. In recent years outbreaks of the related Zika virus (ZIKV) have been associated with birth defects and neurological complications. Read More

    Rapid Assessment Zika Virus Knowledge Among Clinical Specialists in Singapore: A Cross-sectional Survey.
    PLoS Curr 2017 May 3;9. Epub 2017 May 3.
    Department of Obstetrics and Gynecology, Singapore General Hospital, Singapore, Singapore.
    Introduction: We report the results of a rapid assessment of Zika virus awareness among key clinical specialties in Singapore.

    Methods: Between June 6 and June 19, 2016 we conducted an online survey of doctors working in obstetrics and gynaecology, neonatology and paediatrics in Singapore. The survey included 15 multiple choice questions to measure respondents' knowledge of Zika virus in four domains covering clinical and public health. Read More

    Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical-phase framework: Emphasizing risk of severe dengue in the elderly.
    J Microbiol Immunol Infect 2017 Jun 22. Epub 2017 Jun 22.
    Division of Infectious Diseases, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan; Chang Gung University College of Medicine, Kaohsiung, Taiwan. Electronic address:
    Background/purpose: Dengue clinically dynamically changes over time; the World Health Organization (WHO) dengue classification framework proposed 3 dengue clinical phases-febrile (days 1-3), critical (days 4-6) and recovery (days ≥7) phases. This study aimed to better understand clinical and laboratory characteristics in adults (≥18 years) suffering dengue in different clinical phases at their hospital presentations.

    Methods: A retrospective analysis of adults suffering dengue between 2008 and 2014. Read More

    Targeting heat shock factor 1 as an antiviral strategy against dengue virus replication in vitro and in vivo.
    Antiviral Res 2017 Jul 18. Epub 2017 Jul 18.
    Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan. Electronic address:
    Fever onset is correlated with viremia in dengue virus (DENV) patients. Heat shock factor 1 (HSF1), a heat stress response host transcription factor, plays a crucial role in regulating multiple cellular functions, as well as the onset of infectious diseases. This study evaluated the role of HSF1 in DENV replication as a means of regulating DENV infection in vitro and in vivo. Read More

    Evaluation of creatine kinase and liver enzymes in identification of severe dengue.
    BMC Infect Dis 2017 Jul 21;17(1):505. Epub 2017 Jul 21.
    Clinical Research Centre, Hospital Kuala Lumpur, Jalan Pahang, 50586, Kuala Lumpur, Malaysia.
    Background: Existing biomarkers such as AST, ALT and hematocrit have been associated with severe dengue but evidence are mixed. Recently, interests in creatine kinase as a dengue biomarker have risen. These biomarkers represent several underlying pathophysiological processes in dengue. Read More

    Wolbachia and dengue virus infection in the mosquito Aedes fluviatilis (Diptera: Culicidae).
    PLoS One 2017 21;12(7):e0181678. Epub 2017 Jul 21.
    Grupo Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou-Fiocruz, Belo Horizonte, Minas Gerais, Brazil.
    Dengue represents a serious threat to human health, with billions of people living at risk of the disease. Wolbachia pipientis is a bacterial endosymbiont common to many insect species. Wolbachia transinfections in mosquito disease vectors have great value for disease control given the bacterium's ability to spread into wild mosquito populations, and to interfere with infections of pathogens, such as dengue virus. Read More

    Assessment of the Probability of Autochthonous Transmission of Chikungunya Virus in Canada under Recent and Projected Climate Change.
    Environ Health Perspect 2017 Jun 5;125(6):067001. Epub 2017 Jun 5.
    National Microbiology Laboratory , Public Health Agency of Canada , Guelph, Ontario and Saint-Hyacinthe , Québec, Canada.
    Background: Chikungunya virus (CHIKV) is a reemerging pathogen transmitted by Aedes aegypti and Aedes albopictus mosquitoes. The ongoing Caribbean outbreak is of concern due to the potential for infected travelers to spread the virus to countries where vectors are present and the population is susceptible. Although there has been no autochthonous transmission of CHIKV in Canada, there is concern that both Ae. Read More

    Dengue in the elderly: A review.
    Expert Rev Anti Infect Ther 2017 Jul 21. Epub 2017 Jul 21.
    a Department of Infectious Diseases, Institute of Infectious Diseases and Epidemiology , Tan Tock Seng Hospital , Singapore.
    Introduction: Changing dengue epidemiological trends have resulted in a shift in the disease burden to the adult population. Older adults suffer from poorer outcomes as compared to their younger counterparts, making clinical management of this sub-population particularly challenging. Areas covered: We present a review of the current literature on the changing epidemiology of dengue in the elderly, the atypical features of the clinical disease in this population with emphasis on severe disease presentations and challenges in the current management strategies. Read More

    Complete Genome Sequence of a Highly Divergent Dengue Virus Type 2 Strain, Imported into Australia from Sabah, Malaysia.
    Genome Announc 2017 Jul 20;5(29). Epub 2017 Jul 20.
    Public Health Virology Laboratory, Forensic and Scientific Services, Coopers Plains, Queensland, Australia.
    In 2015, a female patient returning to Australia from Sabah, Malaysia, was diagnosed with a suspected sylvatic dengue virus type 2 (DENV-2) infection, becoming the second case of imported highly divergent dengue virus infection recorded in Australia. We describe here the complete genome sequencing of the DENV-2 strain isolated from this patient. Read More

    Conditions for success of engineered underdominance gene drive systems.
    J Theor Biol 2017 Jul 17;430:128-140. Epub 2017 Jul 17.
    The Pirbright Institute, Ash Road, Woking, Surrey, GU24 0NF, UK.
    Engineered underdominance is one of a number of different gene drive strategies that have been proposed for the genetic control of insect vectors of disease. Here we model a two-locus engineered underdominance based gene drive system that is based on the concept of mutually suppressing lethals. In such a system two genetic constructs are introduced, each possessing a lethal element and a suppressor of the lethal at the other locus. Read More

    [Fever and Headache after a Vacation in Thailand].
    Dtsch Med Wochenschr 2017 Jul 20;142(14):1063-1066. Epub 2017 Jul 20.
    History 50 year-old man with fever and headache starting one week after returning from his vacation in Thailand. His general practitioner prescribed amoxicillin/clavulanic acid, without further analyses to pinpoint the infection. Examinations The examination of cerebro-spinal fluid was crucial for the final diagnosis. Read More

    Advances in using Internet searches to track dengue.
    PLoS Comput Biol 2017 Jul 20;13(7):e1005607. Epub 2017 Jul 20.
    Computational Health Informatics Program, Boston Children's Hospital, Boston, MA, USA.
    Dengue is a mosquito-borne disease that threatens over half of the world's population. Despite being endemic to more than 100 countries, government-led efforts and tools for timely identification and tracking of new infections are still lacking in many affected areas. Multiple methodologies that leverage the use of Internet-based data sources have been proposed as a way to complement dengue surveillance efforts. Read More

    Contemporary status of insecticide resistance in the major Aedes vectors of arboviruses infecting humans.
    PLoS Negl Trop Dis 2017 Jul 20;11(7):e0005625. Epub 2017 Jul 20.
    Department of Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom.
    Both Aedes aegytpi and Ae. albopictus are major vectors of 5 important arboviruses (namely chikungunya virus, dengue virus, Rift Valley fever virus, yellow fever virus, and Zika virus), making these mosquitoes an important factor in the worldwide burden of infectious disease. Vector control using insecticides coupled with larval source reduction is critical to control the transmission of these viruses to humans but is threatened by the emergence of insecticide resistance. Read More

    Co-circulation and co-infections of all dengue virus serotypes in Hyderabad, India 2014.
    Epidemiol Infect 2017 Jul 20:1-12. Epub 2017 Jul 20.
    Department of Biotechnology and Bioinformatics,School of Life Sciences, University of Hyderabad,Hyderabad, Telangana State,India.
    The burden of dengue virus infections increased globally during recent years. Though India is considered as dengue hyper-endemic country, limited data are available on disease epidemiology. The present study includes molecular characterization of dengue virus strains occurred in Hyderabad, India, during the year 2014. Read More

    A screen for novel hepatitis C virus RdRp inhibitor identifies a broad-spectrum antiviral compound.
    Sci Rep 2017 Jul 19;7(1):5816. Epub 2017 Jul 19.
    Vaccine and Infectious Disease Research Center, Translational Health Science and Technology Institute, Faridabad, India.
    Hepatitis C virus (HCV) is a global pathogen and infects more than 185 million individuals worldwide. Although recent development of direct acting antivirals (DAA) has shown promise in HCV therapy, there is an urgent need for the development of more affordable treatment options. We initiated this study to identify novel inhibitors of HCV through screening of compounds from the National Cancer Institute (NCI) diversity dataset. Read More

    Comparing patient and healthcare worker experiences during a dengue outbreak in Singapore: understanding the patient journey and the introduction of a point-of-care test (POCT) toward better care delivery.
    BMC Infect Dis 2017 Jul 19;17(1):503. Epub 2017 Jul 19.
    Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, Block MD1, 12 Science Drive 2, Singapore, 117549, Singapore.
    Background: In the aftermath of an upsurge in the number of dengue cases in 2013 and 2014, the SD BIOLINE Dengue Duo rapid diagnostic Point-of-Care Test (POCT) kit was introduced in Tan Tock Seng Hospital, Singapore in June 2013. It is known that the success of POCT usage is contingent on its implementation within the health system. We evaluated health services delivery and the Dengue Duo rapid diagnostic test kit application in Singapore from healthcare workers' perspectives and patient experiences of dengue at surge times. Read More

    Temperature modulates dengue virus epidemic growth rates through its effects on reproduction numbers and generation intervals.
    PLoS Negl Trop Dis 2017 Jul 19;11(7):e0005797. Epub 2017 Jul 19.
    Department of Biological Sciences and Eck Institute for Global Health, University of Notre Dame, Notre Dame, United States of America.
    Epidemic growth rate, r, provides a more complete description of the potential for epidemics than the more commonly studied basic reproduction number, R0, yet the former has never been described as a function of temperature for dengue virus or other pathogens with temperature-sensitive transmission. The need to understand the drivers of epidemics of these pathogens is acute, with arthropod-borne virus epidemics becoming increasingly problematic. We addressed this need by developing temperature-dependent descriptions of the two components of r-R0 and the generation interval-to obtain a temperature-dependent description of r. Read More

    Dengue Virus Coinfection in Human Immunodeficiency Virus-1-Infected Patients on the West Coast of Mexico.
    Am J Trop Med Hyg 2017 Jun 12. Epub 2017 Jun 12.
    Center for Gene Therapy, Hematologic Malignancies and Stem Cell Transplantation Institute, City of Hope, Duarte, California.
    Dengue virus infection in human immunodeficiency virus (HIV)-positive patients is not well studied. Previous reports suggest a transitory inhibition of the HIV-1 viral load, as well as a benign clinical progression of dengue. The follow-up of six HIV-1-infected patients, diagnosed and hospitalized with dengue virus infection in the State of Colima, Mexico, was carried out to analyze the progression of this viral coinfection. Read More

    Why Did Zika Not Explode in Cuba? The Role of Active Community Participation to Sustain Control of Vector-Borne Diseases.
    Am J Trop Med Hyg 2017 Jun 19. Epub 2017 Jun 19.
    Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina.
    As the global public health community develops strategies for sustainable Zika prevention and control, assessment of the Cuban response to Zika provides critical lessons learned. Cuba's early and successful response to Zika, grounded in the country's long-standing dengue prevention and control program, serves as a model of rapid mobilization of intersectoral efforts. Sustaining this response requires applying the evidence generated within the Cuban dengue program that active community participation improves outcomes and is sustainable and cost-effective. Read More

    Differences in Mortality and Clinical Manifestations of Dengue Hemorrhagic Fever in Taiwan in Different Years: A Comparison for Cases in 2014 and 2015 Epidemics.
    Am J Trop Med Hyg 2017 Jun 12. Epub 2017 Jun 12.
    Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsinchu, Taiwan.
    People in southern Taiwan experienced two major dengue outbreaks in 2014 and 2015. The mortality and clinical features were very different between these 2 years. Dengue virus serotype 1 (DENV-1) caused epidemic outbreak in 2014 and DENV-2 was predominant in 2015. Read More

    Fatal Leptospira spp./Zika Virus Coinfection-Puerto Rico, 2016.
    Am J Trop Med Hyg 2017 Jun 26. Epub 2017 Jun 26.
    Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, San Juan, Puerto Rico.
    Coinfection with pathogens that cause acute febrile illness (AFI) can complicate patient diagnosis and management. This report describes a fatal case of Leptospira spp./Zika virus (ZIKV) coinfection in Puerto Rico. Read More

    Epidemiology of Spotted Fever Group Rickettsioses and Acute Undifferentiated Febrile Illness in Villeta, Colombia.
    Am J Trop Med Hyg 2017 Jun 19. Epub 2017 Jun 19.
    Grupo de Enfermedades Infecciosas, Departamento de Microbiología, Pontificia Universidad Javeriana, Bogotá, Colombia.
    Etiology of acute undifferentiated febrile syndrome (AUFS) is often unknown, leading to inaccurate diagnosis and treatment. Villeta town has been identified as an endemic area for spotted fever group (SFG) rickettsioses but little is known about possible amplifier hosts and other Rickettsia species different from Rickettsia rickettsii. Besides, few studies have approached other AUFS etiologies in the region. Read More

    Spatiotemporal clustering of dengue cases in Thiruvananthapuram district, Kerala.
    Indian J Public Health 2017 Apr-Jun;61(2):74-80
    Additional Professor, Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.
    Background: Dengue cases are increasing in Kerala since 2010. Information on clustering of cases across locations and time periods is vital for disease surveillance and timely control.

    Objectives: The objective is to study spatiotemporal clustering of dengue cases and their climatic and physioenvironmental correlates in Thiruvananthapuram district during 2010-2014. Read More

    Survey of malaria and anti-dengue virus IgG among febrile HIV-infected patients attending a tertiary hospital in Abuja, Nigeria.
    HIV AIDS (Auckl) 2017 30;9:145-151. Epub 2017 Jun 30.
    Department of Medical Laboratory Services, University of Abuja Teaching Hospital, FCT Abuja, Nigeria.
    Background: Dengue and malaria are infections, of great public health concern, especially in sub-Saharan Africa where the burden of HIV infection is high. This study was conducted to determine the seroprevalence of dengue virus IgG antibodies and dengue/malaria coinfection among febrile HIV-infected patients attending the University of Abuja Teaching Hospital, Gwagwalada, Abuja.

    Methods: In this cross-sectional study, blood samples from 178 consenting HIV-infected patients receiving antiretroviral therapy were collected and tested for plasmodiasis and anti-Dengue virus IgG using malaria microscopy and ELISA, respectively. Read More

    Dengue Virus Hijacks a Noncanonical Oxidoreductase Function of a Cellular Oligosaccharyltransferase Complex.
    MBio 2017 Jul 18;8(4). Epub 2017 Jul 18.
    Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA
    Dengue virus (DENV) is the most common arboviral infection globally, infecting an estimated 390 million people each year. We employed a genome-wide clustered regularly interspaced short palindromic repeat (CRISPR) screen to identify host dependency factors required for DENV propagation and identified the oligosaccharyltransferase (OST) complex as an essential host factor for DENV infection. Mammalian cells express two OSTs containing either STT3A or STT3B. Read More

    First record of natural vertical transmission of dengue virus in Aedes aegypti from Cuba.
    Acta Trop 2017 Jul 16;174:146-148. Epub 2017 Jul 16.
    Department of Virology, Center for Research, Diagnostic and Reference, CIDR, Institute of Tropical Medicine Pedro Kourí, PAHO-WHO Collaborating Center for Dengue and its Vector, Cuba.
    While horizontal transmission (human-mosquito-human) of dengue viruses largely determines the epidemiology of the disease, vertical transmission (infected female mosquito- infected offspring) has been suggested as a mechanism that ensures maintenance of the virus during adverse conditions for horizontal transmission to occur. The purpose of this study was to analyze the natural infection of larval stages of Aedes aegypti (Diptera: Culicidae) with the dengue virus (DENV) in Cuba. Here, we report vertical transmission of DENV-3 genotype III in natural populations of Ae. Read More

    Dengue prediction by the web: Tweets are a useful tool for estimating and forecasting Dengue at country and city level.
    PLoS Negl Trop Dis 2017 Jul 18;11(7):e0005729. Epub 2017 Jul 18.
    Departamento de Bioquimica e Imunologia do Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
    Background: Infectious diseases are a leading threat to public health. Accurate and timely monitoring of disease risk and progress can reduce their impact. Mentioning a disease in social networks is correlated with physician visits by patients, and can be used to estimate disease activity. Read More

    Dengue vaccines: implications for dengue control.
    Curr Opin Infect Dis 2017 Jul 14. Epub 2017 Jul 14.
    aDivision of Infectious Disease, Johns Hopkins School of Medicine bDepartment of International Health, Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.
    Purpose Of Review: Dengue, the most common arbovirus, is an increasingly significant cause of morbidity worldwide. After decades of research, an approved tetravalent dengue vaccine is finally available. Models constructed using recently available vaccine efficacy data allow for a data-driven discussion of the potential impact of dengue vaccine deployment on global control. Read More

    Experimental Infection with and Maintenance of Cell Fusing Agent Virus (Flavivirus) in Aedes aegypti.
    Am J Trop Med Hyg 2017 Jul;97(1):299-304
    Department of Pathology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas.
    During the past two decades, there has been a dramatic increase in the recognition and characterization of novel insect-specific flaviviruses (ISFVs). Some of these agents are closely related to important mosquito-borne flavivirus pathogens. Results of experimental studies suggest that mosquitoes and mosquito cell cultures infected with some ISFVs are refractory to superinfection with related flavivirus pathogens; and it has been proposed that ISFVs potentially could be used to alter the vector competence of mosquitoes and reduce transmission of specific flavivirus pathogens, such as dengue, West Nile, or Zika viruses. Read More

    Analysis of Clinical and Laboratory Alterations Related to Dengue Case Severity: Comparison between Serotypes 2 and 4 in Brazil.
    Am J Trop Med Hyg 2017 Jul;97(1):137-145
    Viral Immunology Laboratory, Oswaldo Cruz Institute, Rio de Janeiro, Brazil Oswaldo Cruz Institute, Rio de Janeiro, Brazil.
    The increase in severe dengue (SD) cases has caused great impact on public health and has concerned authorities of countries where the disease is endemic and epidemics reach high proportions. The recognition of progression signs of this severe disease during the initial febrile phase can be difficult, since the symptoms are often indistinguishable from other febrile diseases. The aim of this study was to evaluate the clinical manifestations and laboratory findings in patients from two dengue outbreaks and their association with the disease. Read More

    A Fatal Hantavirus Pulmonary Syndrome Misdiagnosed as Dengue: An Investigation into the First Reported Case in Rio de Janeiro State, Brazil.
    Am J Trop Med Hyg 2017 Jul;97(1):125-129
    Laboratório de Hantaviroses e Rickettsioses, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz (FIOCRUZ), Rio de Janeiro, Rio de Janeiro, Brasil.
    We report the results of an investigation into a fatal case of hantavirus pulmonary syndrome (HPS) in Rio de Janeiro State, Brazil, where the disease had not been reported previous to 2015. Following the notification of an HPS case, serum samples were collected from the household members and work contacts of the HPS patient and tested for antibody to hantaviruses. Seroprevalence of 22% (10/45) was indicated for hantavirus out of 45 human samples tested. Read More

    Chikungunya and Zika Virus Cases Detected against a Backdrop of Endemic Dengue Transmission in Vietnam.
    Am J Trop Med Hyg 2017 Jul;97(1):146-150
    Oxford University Clinical Research Unit, Wellcome Trust Major Overseas Programme, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
    Between 2010 and 2014, four chikungunya and two Zika virus infections were identified among 8,105 febrile children in southern Vietnam. Zika viruses were linked to French Polynesian strains, chikungunya to Cambodian strains. Against a backdrop of endemic dengue transmission, chikungunya and Zika present an additional arboviral disease burden in Vietnam. Read More

    Analysis of Dengue Serotype 4 in Sri Lanka during the 2012-2013 Dengue Epidemic.
    Am J Trop Med Hyg 2017 Jul;97(1):130-136
    Duke-NUS Medical School, Singapore.
    The four serotypes of dengue virus (DENV-1, -2, -3, and -4) have had a rapidly expanding geographic range and are now endemic in over 100 tropical and subtropical countries. Sri Lanka has experienced periodic dengue outbreaks since the 1960s, but since 1989 epidemics have become progressively larger and associated with more severe disease. The dominant virus in the 2012 epidemic was DENV-1, but DENV-4 infections were also commonly observed. Read More

    Phase 1 Randomized Study of a Tetravalent Dengue Purified Inactivated Vaccine in Healthy Adults in the United States.
    Am J Trop Med Hyg 2017 Jun;96(6):1325-1337
    Walter Reed Army Institute of Research, Silver Spring, Maryland.
    AbstractThe safety and immunogenicity of four formulations of an investigational tetravalent dengue purified inactivated vaccine (DPIV), formulated at 1 or 4 μg with aluminum hydroxide (alum) or at 1 μg with an adjuvant system (AS01E or AS03B), were evaluated in a first-time-in-human, placebo-controlled, randomized, observer-blind, phase 1 trial in the continental United States. Two doses of vaccine or placebo were administered intramuscularly 4 weeks apart to 100 healthy adults 18-39 years of age, randomized 1:1:1:1:1 to receive one of four DPIV formulations or saline placebo. The response to a third dose was evaluated in a subset of nine participants remote from primary vaccination. Read More

    Low density lipopolyprotein inhibits flavivirus acquisition in Aedes aegypti.
    Insect Mol Biol 2017 Jul 18. Epub 2017 Jul 18.
    Foundational Sciences, Central Michigan University, College of Medicine, Mount Pleasant, MI, USA.
    Aedes aegypti is the primary vector of a number of human pathogens including dengue virus (DENV) and Zika virus (ZIKV). Ae. aegypti acquires these viruses during the processing of bloodmeals obtained from an infected vertebrate host. Read More

    Dengue encephalopathy: very unusual neuroimaging findings.
    J Neurovirol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Neurology, King George's Medical University, UP, Lucknow, 226003, India.
    Neuroimaging, in many patients with dengue encephalopathy, may reveal periventricular signal changes. We report a 25-year-old man, who presented with altered sensorium. Dengue-IgM test in serum was positive. Read More

    Interrelationship between Climatic, Ecologic, Social, and Cultural Determinants Affecting Dengue Emergence and Transmission in Puerto Rico and Their Implications for Zika Response.
    J Trop Med 2017 22;2017:8947067. Epub 2017 Jun 22.
    Department of Global Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, USA.
    Objective: The global resurgence of dengue has been attributed to rapid population growth, urban expansion, increased air travel, globalization, and climate change. Dengue is now endemic in Puerto Rico. Puerto Rico is at risk for Zika, another emerging arbovirus. Read More

    Antibody-based assay discriminates Zika virus infection from other flaviviruses.
    Proc Natl Acad Sci U S A 2017 Jul 17. Epub 2017 Jul 17.
    Humabs BioMed SA, 6500 Bellinzona, Switzerland;
    Zika virus (ZIKV) is a mosquito-borne flavivirus that emerged recently as a global health threat, causing a pandemic in the Americas. ZIKV infection mostly causes mild disease, but is linked to devastating congenital birth defects and Guillain-Barré syndrome in adults. The high level of cross-reactivity among flaviviruses and their cocirculation has complicated serological approaches to differentially detect ZIKV and dengue virus (DENV) infections, accentuating the urgent need for a specific and sensitive serological test. Read More

    Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Risks of Incomplete Immunity to Dengue Virus Revealed by Vaccination.
    Cold Spring Harb Perspect Biol 2017 Jul 17. Epub 2017 Jul 17.
    Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
    Immune enhancement of dengue disease continues to be a concern for those with incomplete immunity in endemic areas. Advanced testing and follow-up of a newly available live attenuated dengue vaccine has recently shown the ability of vaccination to predispose some recipients for a severe outcome on subsequent infection. To improve safety, recommendations have been made to restrict use of the vaccine to those who are likely to have had prior exposure to dengue virus (DENV). Read More

    Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? There Is Only One True Winner.
    Cold Spring Harb Perspect Biol 2017 Jul 17. Epub 2017 Jul 17.
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20817.
    The scientific community now possesses information obtained directly from human beings that makes it possible to understand why breakthrough-enhanced dengue virus (DENV) infections occurred in children receiving Sanofi Pasteur's Dengvaxia tetravalent live attenuated vaccine and to predict the possibility of breakthrough-enhanced DENV infections following immunization with two other tetravalent live attenuated vaccines now in phase III testing. Based upon recent research, Dengvaxia, lacking DENV nonstructural protein antigens, did not protect seronegatives because it failed to raise a competent T-cell response and/or antibodies to NS1. It is also possible that chimeric structure does not present the correct virion conformation permitting the development of protective neutralizing antibodies. Read More

    Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? Questions Raised by the Development and Implementation of Dengue Vaccines: Example of the Sanofi Pasteur Tetravalent Dengue Vaccine.
    Cold Spring Harb Perspect Biol 2017 Jul 17. Epub 2017 Jul 17.
    Research and Development, Sanofi Pasteur, 69007 Lyon, France.
    Dengue is a still-growing public health concern in many tropical and subtropical regions of the world. The development and implementation of an effective dengue vaccine in these regions is a high priority. This insight focuses on the expected characteristics of a safe and efficacious vaccine, referring to the clinical experience obtained during the development of the first tetravalent dengue vaccine from Sanofi Pasteur, now licensed in several endemic countries. Read More

    Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Path to a Dengue Vaccine: Learning from Human Natural Dengue Infection Studies and Vaccine Trials.
    Cold Spring Harb Perspect Biol 2017 Jul 17. Epub 2017 Jul 17.
    Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California 94720-3370.
    Dengue virus (DENV) is the most common arthropod-borne viral disease of humans. Although effective vaccines exist against other flaviviral diseases like yellow fever and Japanese encephalitis, dengue vaccine development is complicated by the presence of four virus serotypes and the possibility of partial immunity enhancing dengue disease severity. Several live attenuated dengue vaccines are being tested in human clinical trials. Read More

    Which Dengue Vaccine Approach Is the Most Promising, and Should We Be Concerned about Enhanced Disease after Vaccination? The Challenges of a Dengue Vaccine.
    Cold Spring Harb Perspect Biol 2017 Jul 17. Epub 2017 Jul 17.
    Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.
    A dengue vaccine has been pursued for more than 50 years and, unlike other flaviviral vaccines such as that against yellow fever, progress has been slow. In this review, we describe progress toward the first licensed dengue vaccine Dengvaxia, which does not give complete protection against disease. The antibody response to the dengue virion is reviewed, highlighting immunodominant yet poorly neutralizing responses in the context of a highly dynamic structurally flexible dengue virus particle. Read More

    Data Preparation for West Nile Virus Agent-Based Modelling: Protocol for Processing Bird Population Estimates and Incorporating ArcMap in AnyLogic.
    JMIR Res Protoc 2017 Jul 17;6(7):e138. Epub 2017 Jul 17.
    University of Manitoba, Electrical and Computer Engineering Department, Winnipeg, MB, Canada.
    Background: West Nile Virus (WNV) was first isolated in 1937. Since the 1950s, many outbreaks have occurred in various countries. The first appearance of infected birds in Manitoba, Canada was in 2002. Read More

    Evaluation of record linkage of two large administrative databases in a middle income country: stillbirths and notifications of dengue during pregnancy in Brazil.
    BMC Med Inform Decis Mak 2017 Jul 17;17(1):108. Epub 2017 Jul 17.
    London School of Hygiene and Tropical Medicine, Keppel St, Bloomsbury, London, WC1E 7HT, UK.
    Background: Due to the increasing availability of individual-level information across different electronic datasets, record linkage has become an efficient and important research tool. High quality linkage is essential for producing robust results. The objective of this study was to describe the process of preparing and linking national Brazilian datasets, and to compare the accuracy of different linkage methods for assessing the risk of stillbirth due to dengue in pregnancy. Read More

    Spatial patterns of dengue cases in Brazil.
    PLoS One 2017 17;12(7):e0180715. Epub 2017 Jul 17.
    Departamento de Física, Universidade Estadual de Maringá, Maringá, Brazil.
    Dengue infection plays a central role in our society, since it is the most prevalent vector-borne viral disease affecting humans. We statistically investigated patterns concerning the spatial spreading of dengue epidemics in Brazil, as well as their temporal evolution in all Brazilian municipalities for a period of 12 years. We showed that the distributions of cases in municipalities follow power laws persistent in time and that the infection scales linearly with the population of the municipalities. Read More

    Community effectiveness of pyriproxyfen as a dengue vector control method: A systematic review.
    PLoS Negl Trop Dis 2017 Jul 17;11(7):e0005651. Epub 2017 Jul 17.
    Institute of Public Health, University of Heidelberg, Heidelberg, Germany.
    Background: Vector control is the only widely utilised method for primary prevention and control of dengue. The use of pyriproxyfen may be promising, and autodissemination approach may reach hard to reach breeding places. It offers a unique mode of action (juvenile hormone mimic) and as an additional tool for the management of insecticide resistance among Aedes vectors. Read More

    Zika virus alters the microRNA expression profile and elicits an RNAi response in Aedes aegypti mosquitoes.
    PLoS Negl Trop Dis 2017 Jul 17;11(7):e0005760. Epub 2017 Jul 17.
    Department of Pathology, Institute for Human Infections and Immunity, Center for Tropical Diseases, Center for Biodefense and Emerging Infectious Disease. University of Texas Medical Branch, Galveston, TX, United States of America.
    Zika virus (ZIKV), a flavivirus transmitted primarily by Aedes aegypti, has recently spread globally in an unprecedented fashion, yet we have a poor understanding of host-microbe interactions in this system. To gain insights into the interplay between ZIKV and the mosquito, we sequenced the small RNA profiles in ZIKV-infected and non-infected Ae. aegypti mosquitoes at 2, 7 and 14 days post-infection. Read More

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