23,268 results match your criteria Dengue


Molecular phylogeny and distribution of dengue virus serotypes circulating in Nepal in 2017.

PLoS One 2020 7;15(7):e0234929. Epub 2020 Jul 7.

Central Department of Biotechnology, Tribhuvan University, Kirtipur, Kathmandu, Nepal.

Dengue virus (DENV) infection is endemic in Nepal. Although infection rates are reported annually, little information is available about the circulating viral serotypes and genotypes. Here, we report the results of a multicentre cross-sectional study of DENV serotypes and genotypes sampled from individuals with suspected DENV infection in Nepal in 2017. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0234929PLOS

Co-infection, co-epidemics of Covid-19 and Dengue in dengue endemic countries: a serious health concern.

J Med Virol 2020 Jul 7. Epub 2020 Jul 7.

Dept. of Entomology, Patuakhali Science and Technology University Bangladesh.

During the Covid-19 pandemic, dengue cases have been increased in most of the dengue-endemic countries in the world. Therefore, in these countries, both Covid-19 and Dengue are occurring simultaneously. The dengue-endemic countries are at the risk of possible co-infection and co-epidemics in where Covid-19 and dengue disease are co-existing, and the viruses are cocirculating. Read More

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http://dx.doi.org/10.1002/jmv.26269DOI Listing

Genetic characterization of dengue virus serotype 2 isolated from dengue fever outbreaks in the eastern Uttar Pradesh and western Bihar, India.

J Med Virol 2020 Jul 7. Epub 2020 Jul 7.

Encephalitis Group, ICMR- National Institute of Virology, Sus Road, Pashan, Pune, India.

Dengue (DEN) is the most common cause of mosquito-borne viral disease endemic in the tropical and subtropical countries. DEN outbreaks associated with multiple dengue virus (DV) serotypes are regularly reported in different parts of India. This study was done during dengue outbreaks in 2015-16 in UP and Bihar in which DEN-2 was found as the only prevalent serotype. Read More

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http://dx.doi.org/10.1002/jmv.26239DOI Listing

A benchmark dataset of protein antigens for antigenicity measurement.

Sci Data 2020 Jul 6;7(1):212. Epub 2020 Jul 6.

Shanghai 10th People's Hospital, School of Life Sciences and Technology, Tongji University, Shanghai, 200092, China.

Antigenicity measurement plays a fundamental role in vaccine design, which requires antigen selection from a large number of mutants. To augment traditional cross-reactivity experiments, computational approaches for predicting the antigenic distance between multiple protein antigens are highly valuable. The performance of in silico models relies heavily on large-scale benchmark datasets, which are scattered among public databases and published articles or reports. Read More

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http://dx.doi.org/10.1038/s41597-020-0555-yDOI Listing

Potent antiviral activity of novel multi-substituted 4-anilinoquin(az)olines.

Bioorg Med Chem Lett 2020 Aug 27;30(16):127284. Epub 2020 May 27.

Structural Genomics Consortium, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address:

Screening a series of 4-anilinoquinolines and 4-anilinoquinazolines enabled identification of potent novel inhibitors of dengue virus (DENV). Preparation of focused 4-anilinoquinoline/quinazoline scaffold arrays led to the identification of a series of high potency 6-substituted bromine and iodine derivatives. The most potent compound 6-iodo-4-((3,4,5-trimethoxyphenyl)amino)quinoline-3-carbonitrile (47) inhibited DENV infection with an EC = 79 nM. Read More

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http://dx.doi.org/10.1016/j.bmcl.2020.127284DOI Listing

A comparison of passive surveillance and active cluster-based surveillance for dengue fever in southern coastal Ecuador.

BMC Public Health 2020 Jul 6;20(1):1065. Epub 2020 Jul 6.

Institute for Global Health and Translational Science, SUNY Upstate Medical University, 505 Irving Avenue Suite 4200, Syracuse, NY, USA.

Background: Dengue is a major emerging infectious disease, endemic throughout the tropics and subtropics, with approximately 2.5 billion people at risk globally. Active (AS) and passive surveillance (PS), when combined, can improve our understanding of dengue's complex disease dynamics to guide effective, targeted public health interventions. Read More

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http://dx.doi.org/10.1186/s12889-020-09168-5DOI Listing

Phylogenetic analysis of the ATP-binding cassette proteins suggests a new ABC protein subfamily J in Aedes aegypti (Diptera: Culicidae).

BMC Genomics 2020 Jul 6;21(1):463. Epub 2020 Jul 6.

Laboratório de Bioquímica e Biologia Molecular de Vetores, Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, 21941-909, Brazil.

Background: We performed an in-depth analysis of the ABC gene family in Aedes aegypti (Diptera: Culicidae), which is an important vector species of arthropod-borne viral infections such as chikungunya, dengue, and Zika. Despite its importance, previous studies of the Arthropod ABC family have not focused on this species. Reports of insecticide resistance among pests and vectors indicate that some of these ATP-dependent efflux pumps are involved in compound traffic and multidrug resistance phenotypes. Read More

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http://dx.doi.org/10.1186/s12864-020-06873-8DOI Listing

Vimentin as a Multifaceted Player and Potential Therapeutic Target in Viral Infections.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Department of Structural and Chemical Biology, Centro de Investigaciones Biológicas Margarita Salas, CSIC, Ramiro de Maeztu, 9, 28040 Madrid, Spain.

Vimentin is an intermediate filament protein that plays key roles in integration of cytoskeletal functions, and therefore in basic cellular processes such as cell division and migration. Consequently, vimentin has complex implications in pathophysiology. Vimentin is required for a proper immune response, but it can also act as an autoantigen in autoimmune diseases or as a damage signal. Read More

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http://dx.doi.org/10.3390/ijms21134675DOI Listing

Generalized Dystonia/Parkinsonism and Double-Doughnut Sign in Dengue Encephalitis.

Mov Disord Clin Pract 2020 Jul 8;7(5):585-586. Epub 2020 May 8.

Department of Neurology Govind Ballabh Pant Postgraduate institute of medical education and research New Delhi India.

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http://dx.doi.org/10.1002/mdc3.12959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7328428PMC

The Clinical Features of Co-circulating Dengue Viruses and the Absence of Dengue Hemorrhagic Fever in Pakistan.

Front Public Health 2020 17;8:287. Epub 2020 Jun 17.

Department of Biology, Baylor University, Waco, TX, United States.

Dengue virus (DENV) is the most common and widespread arboviral infection worldwide. Though all four DENV serotypes cocirculate in nature, the clinicopathological framework of these serotypes is undefined in Pakistan. A cross-sectional, observational study was performed to document the circulation of various arboviruses in the Sindh region of Pakistan. Read More

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http://dx.doi.org/10.3389/fpubh.2020.00287DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311566PMC

Mild Encephalitis/Encephalopathy with Reversible Splenial Change in Dengue Fever: The Boomerang Sign.

Indian J Pediatr 2020 Jul 4. Epub 2020 Jul 4.

Pediatric Neurology Division, Department of Pediatrics, All India Institute of Medical Sciences, Rishikesh, 249203, India.

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http://dx.doi.org/10.1007/s12098-020-03420-xDOI Listing

Cost-efficiency analysis of voluntary vaccination against n-serovar diseases using antibody-dependent enhancement: a game approach.

J Theor Biol 2020 Jul 2:110379. Epub 2020 Jul 2.

Faculty of Engineering Sciences, Kyushu University, Kasuga-koen, Kasuga-shi, Fukuoka 816-8580, Japan; Interdisciplinary Graduate School of Engineering Sciences, Kyushu University, Kasuga-koen, Kasuga-shi, Fukuoka 816-8580, Japan.

Records of epidemics acknowledge immunological multi-serotype illnesses as an important aspect of the occurrence and control of contagious diseases. These patterns occur due to antibody-dependent-enhancement (ADE) among serotype diseases, which leads to infection of secondary infectious classes. One example of this is dengue hemorrhagic fever and dengue shock syndrome, which comprises the following four serotypes: DEN-1, DEN-2, DEN-3, and DEN-4. Read More

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http://dx.doi.org/10.1016/j.jtbi.2020.110379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331570PMC

A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of Type I Interferon.

Antiviral Res 2020 Jul 1:104854. Epub 2020 Jul 1.

Virology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD, 21702.

Recent studies highlight that infection with Coxsackievirus B3, Venezuelan equine encephalitis virus (VEEV), Marburg virus, or stimulation using poly I:C (dsRNA), upregulates the signaling adaptor protein MyD88 and impairs the host antiviral type I interferon (IFN) responses. In contrast, MyD88 deficiency (MyD88) increases the type I IFN and survivability of mice implying that MyD88 up regulation limits the type I IFN response. Reasoning that MyD88 inhibition in a virus-like manner may increase type I IFN responses, our studies revealed lipopolysaccharide stimulation of U937 cells or poly I:C stimulation of HEK293-TLR3, THP1 or U87 cells in the presence of a previously reported MyD88 inhibitor (compound 4210) augmented IFN-β and RANTES production. Read More

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http://dx.doi.org/10.1016/j.antiviral.2020.104854DOI Listing

First report of Chikungunya fever in Rawalpindi, Pakistan.

East Mediterr Health J 2020 Jun 24;26(6):744-747. Epub 2020 Jun 24.

Department of Medicine, Benazir Bhutto Hospital, Rawalpindi Medical University, Rawalpindi, Pakistan.

Background: Chikungunya shares many clinical features with dengue fever, but to date, no case has been reported in Rawalpindi and surrounding areas.

Aims: To detect the presence in Rawalpindi of chikungunya masquerading as dengue fever.

Methods: An observational study was conducted at Rawalpindi Medical University from July to December 2017. Read More

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http://dx.doi.org/10.26719/emhj.19.095DOI Listing

Clinical and Laboratory Profile of Fatal Dengue Cases at a Tertiary Care Private Hospital in Mumbai, India.

Am J Trop Med Hyg 2020 Jul 6. Epub 2020 Jul 6.

Department of Critical Care, Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute, Mumbai, India.

Dengue-related mortality has significantly reduced with early and appropriate fluid resuscitation. However, we continue to see dengue-related fatalities in patients despite early intervention and advanced critical care support. This was a retrospective study conducted at a tertiary care private hospital in Mumbai, India. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0425DOI Listing

Identification of dengue patients with high risk of severe disease, using early clinical and laboratory features, in a resource-limited setting.

Arch Virol 2020 Jul 2. Epub 2020 Jul 2.

Department of Medicine, Faculty of Medicine, University of Kelaniya, P O Box 6, Thalagolla Road, Ragama, GQ, 11010, Sri Lanka.

Only a minority of dengue infections lead to plasma leakage (critical phase [CP]). Early identification of the risk for CP is helpful for triage of patients. This study aimed to identify early clinical predictors of CP that will aid in patient triage during early illness. Read More

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http://dx.doi.org/10.1007/s00705-020-04720-5DOI Listing

Previously Derived Host Gene Expression Classifiers Identify Bacterial and Viral Etiologies of Acute Febrile Respiratory Illness in a South Asian Population.

Open Forum Infect Dis 2020 Jun 26;7(6):ofaa194. Epub 2020 May 26.

Department of Medicine, Duke University School of Medicine, Durham, North Carolina, USA.

Background: Pathogen-based diagnostics for acute respiratory infection (ARI) have limited ability to detect etiology of illness. We previously showed that peripheral blood-based host gene expression classifiers accurately identify bacterial and viral ARI in cohorts of European and African descent. We determined classifier performance in a South Asian cohort. Read More

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http://dx.doi.org/10.1093/ofid/ofaa194DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7314590PMC

Activity of vitamin D receptor agonists against dengue virus.

Sci Rep 2020 Jul 2;10(1):10835. Epub 2020 Jul 2.

Institute of Molecular Biosciences, Mahidol University, Salaya, 73170, Thailand.

Infections with the mosquito-transmitted dengue virus (DENV) are a pressing public health problem in many parts of the world. The recently released commercial vaccine for DENV has encountered some problems, and there is still no effective drug to treat infections. Vitamin D has a well characterized role in calcium and phosphorus homeostasis, but additionally has a role in the immune response to bacterial and viral pathogens. Read More

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http://dx.doi.org/10.1038/s41598-020-67783-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331731PMC

Limited influence of the microbiome on the transcriptional profile of female Aedes aegypti mosquitoes.

Sci Rep 2020 Jul 2;10(1):10880. Epub 2020 Jul 2.

Department of Environmental Sciences, Connecticut Agricultural Experiment Station, New Haven, CT, USA.

The microbiome is an assemblage of microorganisms living in association with a multicellular host. Numerous studies have identified a role for the microbiome in host physiology, development, immunity, and behaviour. The generation of axenic (germ-free) and gnotobiotic model systems has been vital to dissecting the role of the microbiome in host biology. Read More

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http://dx.doi.org/10.1038/s41598-020-67811-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331810PMC

Epidemiology and genetic diversity of circulating dengue viruses in Medellin, Colombia: a fever surveillance study.

BMC Infect Dis 2020 Jul 2;20(1):466. Epub 2020 Jul 2.

Department of Pathobiological Sciences, University of Wisconsin, 500 Lincoln Dr, Madison, WI, 53706, USA.

Background: Dengue fever is a major public health problem in Colombia. A fever surveillance study was conducted for evaluation of the clinical, epidemiological, and molecular patterns of dengue, prior to Chikungunya and Zika epidemics.

Methods: In November 2011-February 2014, a passive facility-based surveillance was implemented in Santa Cruz Hospital, Medellin, and enrolled eligible febrile patients between 1 and 65 years-of-age. Read More

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http://dx.doi.org/10.1186/s12879-020-05172-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331258PMC

Clinical characteristics, histopathology, and tissue immunolocalization of chikungunya virus antigen in fatal cases.

Clin Infect Dis 2020 Jul 2. Epub 2020 Jul 2.

Centers for Disease Control and Prevention - Infectious Diseases Pathology Branch, Atlanta, Georgia, United States of America.

Background: Death in patients with chikungunya is rare, and has been associated with encephalitis, hemorrhage, and septic shock. We describe clinical, histologic and immunohistochemical findings in individuals who died following chikungunya virus (CHIKV) infection.

Methods: We identified individuals who died in Puerto Rico during 2014 following an acute illness, and had CHIKV RNA detected by RT-PCR in a pre- or post-mortem blood or tissue specimen. Read More

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http://dx.doi.org/10.1093/cid/ciaa837DOI Listing
July 2020
8.886 Impact Factor

Knowledge, attitudes and bite prevention practices and estimation of productivity of vector breeding sites using a Habitat Suitability Score (HSS) among households with confirmed dengue in the 2014 outbreak in Dar es Salaam, Tanzania.

PLoS Negl Trop Dis 2020 Jul 2;14(7):e0007278. Epub 2020 Jul 2.

Environmental Health and Ecological Sciences Department, Ifakara Health Institute, Tanzania.

Background: The frequency and magnitude of dengue epidemics has increased dramatically throughout the tropics in the past 40 years due to unplanned urbanization, globalization and lack of effective mosquito control. The commercial capital of Tanzania, Dar es Salaam, is now experiencing regular dengue outbreaks. Three dengue serotypes have been detected in Dar es Salaam (DNV 1, 2 and 3). Read More

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http://dx.doi.org/10.1371/journal.pntd.0007278DOI Listing

Recent influenza activity in tropical Puerto Rico has become synchronized with mainland US.

Influenza Other Respir Viruses 2020 Jul 2. Epub 2020 Jul 2.

Centers for Disease Control and Prevention, San Juan, Puerto Rico.

Background: We used data from the Sentinel Enhanced Dengue Surveillance System (SEDSS) to describe influenza trends in southern Puerto Rico during 2012-2018 and compare them to trends in the United States.

Methods: Patients with fever onset ≤ 7 days presenting were enrolled. Nasal/oropharyngeal swabs were tested for influenza A and B viruses by PCR. Read More

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http://dx.doi.org/10.1111/irv.12744DOI Listing

mosquito surveillance and the use of a larvicide for vector control in a rural area of the Lao People's Democratic Republic.

Trop Med Health 2020 30;48:54. Epub 2020 Jun 30.

Department of Hygiene and Public Health, Kansai Medical University, Hirakata, Osaka, Japan.

Background: Refillable water containers are commonly used in rural areas of Lao PDR, and they act as mosquito breeding sites. and mosquitos are transmission vectors for the dengue virus, which causes dengue fever.

Methods: Two isolated rural villages in the central part of Lao PDR were selected as study sites. Read More

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http://dx.doi.org/10.1186/s41182-020-00242-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325043PMC

Vietnam Climate Change and Health Vulnerability and Adaptation Assessment, 2018.

Environ Health Insights 2020 22;14:1178630220924658. Epub 2020 Jun 22.

Vice-Rector, Hanoi University of Public Health, Hanoi, Vietnam.

Background: The Global Climate Risk Index 2020 ranked Vietnam as the sixth country in the world most affected by climate variability and extreme weather events over the period 1999-2018. Sea level rise and extreme weather events are projected to be more severe in coming decades, which, without additional action, will increase the number of people at risk of climate-sensitive diseases, challenging the health system. This article summaries the results of a health vulnerability and adaptation (V&A) assessment conducted in Vietnam as evidences for development of the National Climate Change Health Adaptation Plan to 2030. Read More

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http://dx.doi.org/10.1177/1178630220924658DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7309337PMC

[Emerging and Re-emerging Virus Infections in Japan: Dengue Fever, Zika Virus Disease, and SFTS].

Authors:
Masayuki Saijo

Yakugaku Zasshi 2020 ;140(7):895-899

Department of Virology I, National Institute of Infectious Diseases.

A sporadic but autochthonous dengue fever outbreak occurred in Tokyo in 2014, although the dengue virus is not in general circulation in Japan. Another lethal infectious disease, known as severe fever with thrombocytopenia syndrome (SFTS), was discovered to be endemic to Japan in January 2013. More than 400 patients with SFTS have been reported so far. Read More

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http://dx.doi.org/10.1248/yakushi.19-00255-2DOI Listing
January 2020

Circulation of Various Dengue Serotypes in Community Based Study in Jakarta, Indonesia.

Jpn J Infect Dis 2020 Jun 30. Epub 2020 Jun 30.

Department of Microbiology Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital,, Universitas Indonesia, Indonesia.

Dengue virus (DENV) infection is still a serious health problem in Indonesia. Community based dengue study to determine circulated DENV in certain place and time is limited due to expensive cost and effort. Many DENV infected patients are not admitted to the hospital, and many patients come to the hospital at later phase of disease. Read More

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http://dx.doi.org/10.7883/yoken.JJID.2019.431DOI Listing

Dimerization of dengue virus E-subunits impacts antibody function and domain focus.

J Virol 2020 Jul 1. Epub 2020 Jul 1.

Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC, USA.

Dengue virus (DENV) is responsible for the most prevalent and significant arthropod-borne viral infection of humans. The leading DENV vaccines are based on tetravalent live-attenuated virus platforms. In practice, it has been challenging to induce balanced and effective responses to each of the four DENV serotypes because of differences in the replication efficiency and immunogenicity of individual vaccine components. Read More

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http://dx.doi.org/10.1128/JVI.00745-20DOI Listing

Sero-prevalence of arthropod-borne viral infections among Lukanga swamp residents in Zambia.

PLoS One 2020 1;15(7):e0235322. Epub 2020 Jul 1.

Centre for Infectious Diseases Research in Zambia, Lusaka, Zambia.

Introduction: The re-emergence of vector borne diseases affecting millions of people in recent years has drawn attention to arboviruses globally. Here, we report on the sero-prevalence of chikungunya virus (CHIKV), dengue virus (DENV), mayaro virus (MAYV) and zika virus (ZIKV) in a swamp community in Zambia.

Methods: We collected blood and saliva samples from residents of Lukanga swamps in 2016 during a mass-cholera vaccination campaign. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235322PLOS

Blood pressure trend in hospitalized adult dengue patients.

PLoS One 2020 1;15(7):e0235166. Epub 2020 Jul 1.

Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.

Background: Monitoring of blood pressure is an important part of management of dengue illness. Large scale studies of temporal trend of blood pressure in adult dengue are lacking. In this study, we examined the differences in time trend of systolic (SBP) and diastolic blood pressure (DBP) in patients with and without severe dengue (SD), dengue hemorrhagic fever (DHF) and pre-existing hypertension, and elderly versus non-elderly patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0235166PLOS

Burden of dengue in the State of Meta, Colombia (2010-2016).

Cad Saude Publica 2020 26;36(6):e00055119. Epub 2020 Jun 26.

Escuela de Graduados, Universidad CES, Medellín, Colombia.

In Colombia, dengue is a disease of great impact due to its morbidity and mortality, however, studies on the effects of the economic burden at the local level are scarce. Therefore, our study sought to describe the economic burden of dengue epidemics between 2010 and 2016 in the State of Meta, Colombia. A longitudinal study was performed using information from the records of the epidemiological information system (Sistema Nacional de Vigilancia en Salud Pública - SIVIGILA), and the indicator of disability-adjusted life years (DALYs) was determined as an estimator of the burden of dengue. Read More

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http://dx.doi.org/10.1590/0102-311X00055119DOI Listing

Is the COVID-19 pandemic masking dengue epidemic in Bangladesh?

J Adv Vet Anim Res 2020 Jun 15;7(2):218-219. Epub 2020 Apr 15.

Department of Microbiology and Hygiene, Faculty of Veterinary Science, Bangladesh Agricultural University, Mymensingh 2202, Bangladesh.

COVID-19 is now a pandemic. Like other countries, Bangladesh is putting all its efforts to combat this pandemic. Dengue is a mosquito-borne viral infection causing a severe flu-like illness and, sometimes causing a potentially lethal complication called severe dengue. Read More

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http://dx.doi.org/10.5455/javar.2020.g412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7320811PMC

A New Class of Dengue and West Nile Virus Protease Inhibitors With Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays.

J Med Chem 2020 Jul 1. Epub 2020 Jul 1.

Dengue and West Nile virus are rapidly spreading global pathogens for which no specific therapeutic treatments are available. One of the promising targets for drug discovery against dengue and other flaviviruses is the viral serine protease NS2B-NS3. We present the design, synthesis, in vitro and cellular characterization of a novel chemotype of potent, small molecular non-peptidic dengue protease inhibitors derived from 4-benzyloxyphenylglycine. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.0c00413DOI Listing

Validation of a Novel Zebrafish Model of Dengue Virus (DENV-3) Pathology Using the Pentaherbal Medicine Denguenil Vati.

Biomolecules 2020 Jun 28;10(7). Epub 2020 Jun 28.

Drug Discovery and Development Division, Patanjali Research Institute, NH-58, Haridwar 249 405, Uttarakhand, India.

Dengue is a devastating viral fever of humans, caused by dengue virus. Using a novel zebrafish model of dengue pathology, we validated the potential anti-dengue therapeutic properties of pentaherbal medicine, Denguenil Vati. At two different time points (at 7 and 14 days post infection with dengue virus), we tested three translational doses (5. Read More

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http://dx.doi.org/10.3390/biom10070971DOI Listing

Ross River Virus Provokes Differentially Expressed MicroRNA and RNA Interference Responses in Mosquitoes.

Viruses 2020 Jun 27;12(7). Epub 2020 Jun 27.

Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD 4072, Australia.

Alphaviruses are globally distributed and predominately transmitted by mosquitoes. species are common vectors for the clinically important alphaviruses-Chikungunya, Sindbis, and Ross River (RRV) viruses-with also being a vector for the flaviviruses dengue, Yellow Fever, and Zika viruses. was putatively implicated in the large 1979-1980 South Pacific Islands outbreak of RRV-the leading cause of arboviral disease in Australia today. Read More

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http://dx.doi.org/10.3390/v12070695DOI Listing

Central nervous system infections in a tropical area: Influence of emerging and rare infections.

Eur J Neurol 2020 Jun 30. Epub 2020 Jun 30.

Centre Hospitalier Universitaire de la Guadeloupe, Service de Neurologie, Pointe-à-Pitre, Abymes, French West Indies, France.

Background And Purpose: The frequency of infectious encephalitis and the distribution of causative pathogens in the tropical areas are poorly known and may be influenced by emerging and rare infections. The aim was to characterize a large series of acute infectious encephalitis and myelitis in immunocompetent patients from the Caribbean island of Guadeloupe identifying clinical, biological and radiological features according to pathogens.

Methods: Using a hospital database, we retrospectively collected detailed information on a comprehensive series of immunocompetent patients with acute infectious myelitis and encephalitis over the 2012-2018 period. Read More

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http://dx.doi.org/10.1111/ene.14422DOI Listing

Ideal Criteria for Accurate Mouse Models of Vector-Borne Diseases with Emphasis on Scrub Typhus and Dengue.

Am J Trop Med Hyg 2020 Jun 29. Epub 2020 Jun 29.

Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch, Galveston, Texas.

Nine criteria regarding the infectious agent, mode of transmission, portal of entry, route of spread, target organs, target cells, pathologic lesions, incubation period, and modifiable spectrum of disease and outcomes appropriate to the intended experimental purpose are described. To provide context for each criterion, mouse models of two vector-borne zoonotic infectious diseases, scrub typhus and dengue, are summarized. Application of the criteria indicates that intravenous inoculation of into inbred mice is the best current model for life-threatening scrub typhus, and intradermal inoculation accurately models sublethal human scrub typhus, whereas the immunocompromised mouse models of dengue provide disease outcomes most closely associated with human dengue. Read More

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http://dx.doi.org/10.4269/ajtmh.19-0955DOI Listing

A new knockdown resistance (kdr) mutation, F1534L, in the voltage-gated sodium channel of Aedes aegypti, co-occurring with F1534C, S989P and V1016G.

Parasit Vectors 2020 Jun 29;13(1):327. Epub 2020 Jun 29.

National Institute of Malaria Research, Sector 8, Dwarka, Delhi, 110077, India.

Background: Aedes aegypti is a primary vector of dengue, chikungunya and Zika infections in India. In the absence of specific drugs or safe and effective vaccines for these infections, their control relies mainly on vector control measures. The emergence of insecticide resistance in vectors, especially against pyrethroids, is a serious threat to the insecticide-based vector control programme. Read More

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http://dx.doi.org/10.1186/s13071-020-04201-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7325290PMC

COVID-19 and dengue: Pushing the peruvian health care system over the edge.

Travel Med Infect Dis 2020 Jun 26:101808. Epub 2020 Jun 26.

Universidad San Ignacio de Loyola, Unidad de Investigación para la Generación y Síntesis de Evidencias en Salud, Lima, Peru. Electronic address:

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http://dx.doi.org/10.1016/j.tmaid.2020.101808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318981PMC

Insecticide Resistance of Aedes albopictus in Zhejiang Province, China.

Biosci Trends 2020 Jun 27. Epub 2020 Jun 27.

Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China.

From 2003 until 2018, a total of 12 outbreaks with 1,654 confirmed dengue cases have been reported in Zhejiang Province. The emergence of insecticide resistance in mosquitoes will affect the control of dengue. Our study aims to investigate the current situation of insecticide resistance of Ae. Read More

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http://dx.doi.org/10.5582/bst.2020.03194DOI Listing

Dengue virus co-infections with multiple serotypes do not result in a different clinical outcome compared to mono-infections.

Epidemiol Infect 2020 06 29;148:e119. Epub 2020 Jun 29.

Department of Microbiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka.

Circulation of multiple dengue virus (DENV) serotypes in a locale has resulted in individuals becoming infected with mixed serotypes. This research was undertaken to study the clinical presentation, presence of DENV serotypes and serological characteristics of DENV infected patients with co-infections from three Provinces of Sri Lanka where DENV-1 and -2 predominated during the study. A reverse transcription polymerase chain reaction was performed on 1249 patient samples and 301 were positive for DENV (24. Read More

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http://dx.doi.org/10.1017/S0950268820000229DOI Listing

Acute Encephalopathy with Biphasic Seizures and Late Reduced Diffusion Associated with Dengue Infection in a Child.

J Trop Pediatr 2020 Jun 28. Epub 2020 Jun 28.

Department of Pediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai 600116, India.

Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is a clinico-radiological syndrome in children secondary to viral or bacterial infections. The causes include viral (influenza, human herpes virus-6, adenovirus, rota) as well as bacterial infections. However, AESD with dengue infection has not been reported earlier. Read More

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http://dx.doi.org/10.1093/tropej/fmaa033DOI Listing

Patterns of signs, symptoms and laboratory values associated with Zika, dengue and undefined acute illnesses in a dengue endemic region: secondary analysis of a prospective cohort study in southern México.

Int J Infect Dis 2020 Jun 25. Epub 2020 Jun 25.

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA; Departamento de Infectologia, Instituto Nacional de Ciencias Médicas y Nutricion Salvador Zubiran, Mexico City, Mexico.

Objectives: Dengue and Zika infections cause illnesses with overlapping clinical manifestations. We aimed to explore the association of each of these infections with single or grouped clinical and laboratory parameters.

Methods: We prospectively collected clinical and laboratory data from a cohort of patients seeking care for symptoms meeting the Pan American Health Organization's modified case-definition criteria for probable Zika virus infection. Read More

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http://dx.doi.org/10.1016/j.ijid.2020.06.071DOI Listing

Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2.

ALTEX 2020 Jun 26. Epub 2020 Jun 26.

Johns Hopkins University, Bloomberg School of Public Health, Center for Alternatives to Animal Testing (CAAT), Baltimore, MD, USA.

Reports from Wuhan suggest that 36% of COVID-19 patients show neurological symptoms, and cases of viral encephalitis have been reported, suggesting that the virus is neurotropic under unknown circumstances. This is well established for other coronaviruses. In order to understand why some patients develop such symptoms and others do not, we address herein the infectability of the central nervous system (CNS). Read More

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http://dx.doi.org/10.14573/altex.2006111DOI Listing

Case report: An unusual presentation of acute promyelocytic leukemia in a middle aged female mimicking dengue infection.

Medicine (Baltimore) 2020 Jun;99(26):e21011

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Bronx Care Health System, Affiliated With Icahn School of Medicine at Mount Sinai, 1650 Grand Concourse, Bronx, NY.

Rationale: Acute promyelocytic leukemia (APL) is an uncommon subtype of acute myeloid leukemia (AML). M3v phenotype is a less common presentation of APL and these patients usually present with leukocytosis and abnormal promyelocytes that are characterized by sparse granulation and are less likely to have faggot cells with multiple Auer rods. Distinguishing M3v phenotype from acute febrile illness can be challenging as the diagnosis relies on examination of peripheral smear. Read More

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http://dx.doi.org/10.1097/MD.0000000000021011DOI Listing
June 2020
5.723 Impact Factor

Out of the frying pan and into the fire? Due diligence warranted for ADE in COVID-19.

Microbes Infect 2020 Jun 24. Epub 2020 Jun 24.

Department of Health Sciences, Faculty of Applied Health Sciences, Brock University, St. Catharines, Ontario, L2S 3A1, Canada. Electronic address:

Antibody-dependent enhancement (ADE) is an atypical immunological paradox commonly associated with dengue virus re-infection. However, various research models have demonstrated this phenomenon with other viral families, including Coronaviridae. Recently, ADE in SARS-CoV-2 has emerged as one hypothesis to explain severe clinical manifestations. Read More

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http://dx.doi.org/10.1016/j.micinf.2020.06.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311339PMC

Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins.

J Gen Virol 2020 Jun 26. Epub 2020 Jun 26.

Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.

The dengue virus (DENV) replication complex is made up of its non-structural (NS) proteins and yet-to-be identified host proteins, but the molecular interactions between these proteins are not fully elucidated. In this work, we sought to uncover the interactions between DENV NS1 and its fellow NS proteins using a yeast two-hybrid (Y2H) approach, and found that domain II of NS1 binds to an N-terminal cytoplasmic fragment of NS4A. Mutations in amino acid residues 41 and 43 in this cytoplasmic region of NS4A disrupted the interaction between NS1 and the NS4A-2K-4B precursor protein. Read More

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http://dx.doi.org/10.1099/jgv.0.001462DOI Listing

Seroprevalence of Dengue, Zika, and Chikungunya Viruses in Wild Monkeys in Thailand.

Am J Trop Med Hyg 2020 Jun 22. Epub 2020 Jun 22.

Department of Microbiology and Immunology, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Zoonotic pathogens such as arboviruses have comprised a significant proportion of emerging infectious diseases in humans. The role of wildlife species as reservoirs for arboviruses is poorly understood, especially in endemic areas such as Southeast Asia. This study aims to determine the exposure history of different macaque species from national parks in Thailand to mosquito-borne flaviviruses and alphavirus by testing the serum samples collected from 25 northern pigtailed macaques, 33 stump-tailed macaques, and 4 long-tailed macaques for the presence of antibodies against dengue, Zika, and chikungunya viruses by plaque reduction neutralization assay. Read More

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http://dx.doi.org/10.4269/ajtmh.20-0057DOI Listing

COVID-19 and dengue: a deadly duo.

Authors:
Raiiq Ridwan

Trop Doct 2020 Jun 26:49475520936874. Epub 2020 Jun 26.

Specialty Trainee in Emergency Medicine, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

While COVID-19 wreaks havoc across the world, countries in South and South-East Asia and Latin America are faced with the prospect of a second epidemic: dengue. Further complicating the picture is that the early signs and symptoms of dengue and COVID-19 could be similar, making it a risk that patients may be wrongly diagnosed early in the course of disease. This is confounded further by a report from Singapore of false-positive dengue antibody testing in two COVID-19 patients, and the presence of co-infection of dengue and COVID-19 in Thailand. Read More

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http://dx.doi.org/10.1177/0049475520936874DOI Listing

A spatial-temporal study for the spread of dengue depending on climate factors in Pakistan (2006-2017).

BMC Public Health 2020 Jun 25;20(1):995. Epub 2020 Jun 25.

Quaid-i-Azam University, Islamabad, 45000, Pakistan.

Background: In Pakistan, dengue fever has become a major concerning factor, given that it is a relatively new disease compared to malaria. The number of people affected by dengue fever has increased at least 10-fold in the last 15 years in specific areas of Pakistan. Therefore, it is necessary to analyse this disease to reduce or prevent the effects of dengue fever in the region. Read More

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http://dx.doi.org/10.1186/s12889-020-08846-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7318413PMC