25,811 results match your criteria Dengue


Immunophenotyping and transcriptional profiling of human plasmablasts in dengue.

J Virol 2021 Sep 15:JVI0061021. Epub 2021 Sep 15.

ICGEB-Emory Vaccine Center, International Center for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India.

Plasmablasts represent a specialized class of antibody secreting effector B cell population that transiently appear in blood circulation following infection or vaccination. The expansion of these cells generally tends to be massive in patients with systemic infections leading to viral hemorrhagic fevers such as dengue or ebola. To gain a detailed understanding of the human plasmablast responses beyond antibody expression, here we performed immunophenotyping and RNA seq analysis of the plasmablasts from dengue febrile children in India. Read More

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September 2021

Dengue and Coronavirus disease (COVID-19) syndemic: Double threat to an overburdened healthcare system in Africa.

Int J Health Plann Manage 2021 Sep 14. Epub 2021 Sep 14.

Department of Entomology, Kansas State University, Manhattan, Kansas, USA.

Dengue fever (DF) is a significant public health problem in the African continent. The primary prevention strategy against the disease is vaccination and entomological control of vectors; however, implementing such a strategy in several countries in the continent is far below what is necessary to control the disease. The Coronavirus disease (COVID-19) pandemic further aggravated this situation and negatively impacted these measures, mainly the coverage of vaccination campaigns, due to restrictive measures to control the disease. Read More

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September 2021

Dengue Myocarditis Complicated by COVID-19: A Case Report on Dual Viral Infection.

Cureus 2021 Aug 10;13(8):e17076. Epub 2021 Aug 10.

General Medicine, Government Medical College and Hospital, Chandigarh, IND.

During the ongoing pandemic of coronavirus disease 2019 (COVID-19), it is crucial for clinicians to have an insight into the emerging co-infections. As the dengue virus (DENV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have related symptomatology, a high index of suspicion is required for prompt diagnosis of concurrent infections involving these two pathogens, especially in the areas endemic for tropical diseases, i.e. Read More

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Splenic Infarction Induced by Dengue Hemorrhagic Fever: A Rare Presentation.

Cureus 2021 Aug 10;13(8):e17072. Epub 2021 Aug 10.

Internal Medicine, Umm Al-Qura University, Mecca, SAU.

Haematological and vascular features of dengue virus infection are common and vary from tiny skin haemorrhages to significant bleeding such as epistaxis, gastrointestinal bleeding and hematuria. Spontaneous splenic rupture has also been reported as an atypical manifestation in dengue fever. We report a case of splenic infarction in a 35-year-old man who presented with fever, vomiting, diffuse abdominal pain and distention, diarrhoea, hematuria, headache, back pain, hypotension, pleural effusion and ascites. Read More

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Third-generation smallpox vaccine strain-based recombinant vaccines for viral hemorrhagic fevers.

Authors:
Tomoki Yoshikawa

Vaccine 2021 Sep 11. Epub 2021 Sep 11.

Department of Virology 1, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashimurayama-shi, Tokyo 208-0011, Japan. Electronic address:

Vaccinia virus has been used as a smallpox vaccine. Now that smallpox has been eradicated, the vaccinia virus is expected to be used as a bioterrorism countermeasure and a recombinant vaccine vector for other infectious diseases, such as viral hemorrhagic fevers. Many vaccinia virus strains were used as smallpox vaccines in the smallpox eradication campaign coordinated by the World Health Organization. Read More

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September 2021

Hyperendemicity associated with increased dengue burden.

J R Soc Interface 2021 Sep 15;18(182):20210565. Epub 2021 Sep 15.

Environmental Health Institute, National Environmental Agency, Singapore.

Over 105 million dengue infections are estimated to occur annually. Understanding the disease dynamics of dengue is often difficult due to multiple strains circulating within a population. Interactions between dengue serotype dynamics may result in complex cross-immunity dynamics at the population level and create difficulties in terms of formulating intervention strategies for the disease. Read More

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September 2021

Dengue virus in humans and mosquitoes and their molecular characteristics in northeastern Thailand 2016-2018.

PLoS One 2021 14;16(9):e0257460. Epub 2021 Sep 14.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.

Dengue is hyperendemic in most Southeast Asian countries including Thailand, where all four dengue virus serotypes (DENV-1 to -4) have circulated over different periods and regions. Despite dengue cases being annually reported in all regions of Thailand, there is limited data on the relationship of epidemic DENV infection between humans and mosquitoes, and about the dynamics of DENV during outbreaks in the northeastern region. The present study was conducted in this region to investigate the molecular epidemiology of DENV and explore the relationships of DENV infection in humans and in mosquitoes during 2016-2018. Read More

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September 2021

Identification of Phasi Charoen-Like Phasivirus in Field Collected from Karnataka State, India.

Vector Borne Zoonotic Dis 2021 Sep 14. Epub 2021 Sep 14.

Directorate of Health and Family Welfare Services, Bangalore, Karnataka, India.

A wide range of insect-specific viruses (ISVs) have been reported worldwide. There are no studies from India that have reported ISVs. The current study describes the identification of Phasi Charoen-like virus (PCLV) from mosquito-pools from six districts of Karnataka state, India. Read More

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September 2021

Clinicopathologic features between different viral epidemic outbreaks involving the skin.

Clin Dermatol 2021 May-Jun;39(3):405-417. Epub 2021 Apr 25.

Dermatology Clinic, Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy; Vita-SaluteS.Raffaele University, Milan, Italy.

The current coronavirus disease 2019 pandemic has exceeded any epidemiologic prevision, but increasing information suggests some analogies with the major viral outbreaks of the last century. A general warning has been issued on the possibility that coinfections can make differential diagnosis and treatment difficult, especially in tropical countries. Some reports have pointed out that the presence of high Dengue antibodies can give a false-negative result for severe acute respiratory syndrome coronavirus 2. Read More

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Seroprevalence of Zika virus in pregnant women from central Thailand.

PLoS One 2021 13;16(9):e0257205. Epub 2021 Sep 13.

Center of Research Excellence in Immunoregulation, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Zika virus (ZKV) infection in a pregnant woman, especially during the first trimester, often results in congenital anomalies. However, the pathogenic mechanism is unknown and one-third of ZKV infected pregnancies are asymptomatic. Neutralizing antibodies against ZKV has been reported in 70% of Thai adults, but the prevalence among pregnant women is unknown. Read More

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September 2021

Overview of Pathogenesis, Diagnostics, and Therapeutics of Infectious Diseases: Dengue and Zika.

ACS Omega 2021 Sep 26;6(35):22487-22496. Epub 2021 Aug 26.

Chemistry Division, School of Advanced Sciences, Vellore Institute of Technology, Chennai Campus, Vandalur-Kelambakkam Road, Chennai 600 127, Tamil Nadu, India.

The emergence of more virulent SARS virus has made scientists look back at other so-called neglected diseases such as dengue, Zika, and chikungunya, etc. Until recently these neglected diseases have not received much attention for their control or elimination from society. Over the past decade several attempts to investigate the pathogenicity, diagnostic, and therapeutic strategies for flavivirus caused diseases have been made. Read More

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September 2021

Dengue Virus Dysregulates Master Transcription Factors and PI3K/AKT/mTOR Signaling Pathway in Megakaryocytes.

Front Cell Infect Microbiol 2021 26;11:715208. Epub 2021 Aug 26.

Laboratory of Virology, National Institute of Immunology, New Delhi, India.

Dengue virus (DENV) infection can cause either self-limited dengue fever or hemorrhagic complications. Low platelet count is one of the manifestations of dengue fever. Megakaryocytes are the sole producers of platelets. Read More

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Cytokines Storm in COVID-19 with Dengue Co-infection in Pregnancy: Fatal Maternal and Fetal Outcome.

IDCases 2021 Sep 6:e01284. Epub 2021 Sep 6.

Department of Obstetrics and Gynecology, Universitas Indonesia, Indonesia.

We report a 23-year-old pregnant woman who presented with acute high-grade fever, vomiting, and diarrhea for 5 days. She was first hospitalized in RSUD Tangerang-a secondary hospital based in Tangerang and were referred to Cipto Mangunkusumo General Hospital as a tertiary hospital. Initial laboratory results from previous hospital revealed leukopenia, low platelet, elevated aspartate transaminase, and alanine transaminase. Read More

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September 2021

Global burden for dengue and the evolving pattern in the past 30 years.

J Travel Med 2021 Sep 11. Epub 2021 Sep 11.

Clinical Epidemiology Unit, Qilu Hospital of Shandong University, Jinan, Shandong, People's Republic of China.

Background: Dengue is the most prevalent and rapidly spreading mosquito-borne viral disease. We present the global, regional, and national burden of dengue from 1990 to 2019 based on the findings from the Global Burden of Diseases, Injures, and Risk Factors Study 2019 (GBD 2019).

Methods: Based upon GBD 2019 dengue data on age-standardized incidence rate (ASIR), age-standardized death rate (ASDR) and age-standardized disability-adjusted life years (DALYs) rate, this study estimates and presents annual percentage change (EAPC) to quantify trends over time to assess potential correlates of increased dengue activity such as global travel, and warming. Read More

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September 2021

SAR of novel benzothiazoles targeting an allosteric pocket of DENV and ZIKV NS2B/NS3 proteases.

Bioorg Med Chem 2021 Sep 4;47:116392. Epub 2021 Sep 4.

Institute of Pharmaceutical and Biomedical Sciences, Johannes Gutenberg-University, Staudingerweg 5, 55128 Mainz, Germany. Electronic address:

In recent years, dengue virus (DENV) and Zika virus (ZIKV), both mosquito-borne members of the Flaviviridae family, have emerged as intercontinental health issues since their vectors have spread from their tropical origins to temperate climate zones due to climate change and increasing globalization. DENV and ZIKV are positive-sense, single-stranded RNA viruses, whose genomes consist of three structural (capsid, membrane precursor, envelope) and seven non-structural (NS) proteins, all of which are initially expressed as a single precursor polyprotein. For virus maturation, the polyprotein processing is accomplished by host proteases and the viral NS2B/NS3 protease complex, whose inhibitors have been shown to be effective antiviral agents with loss of viral pathogenicity. Read More

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September 2021

In-vitro antiviral action ofeupatorium perfoliatum against dengue virus infection: Modulation of mTOR signaling and autophagy.

J Ethnopharmacol 2021 Sep 9:114627. Epub 2021 Sep 9.

Department of Virology, Dr. Anjali Chatterjee Regional Research Institute, Kolkata, 700035, India. Electronic address:

Ethnopharmacological Relevance: Dengue virus (DENV) is a re-emerging mosquito-borne Flavivirus that has recently engendered large epidemics around the world. Consequently antivirals with effective anti-DENV therapeutic activity are urgently required. In the 18th century, Europeans, as well as native inhabitants of North America, were known to adapt the medicinal property of the common perennial plant Eupatorium perfoliatum L. Read More

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September 2021

Zika virus infection in pregnant women and their children: A review.

Eur J Obstet Gynecol Reprod Biol 2021 Jul 9;265:162-168. Epub 2021 Jul 9.

ISGlobal, Hospital Clínic-Universitat de Barcelona, Barcelona, Spain; Consorcio de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain; Centro de Investigação em Saúde de Manhiça (CISM), Manhiça, Maputo, Mozambique. Electronic address:

Zika virus (ZIKV) is an arthropod-borne virus (arbovirus) transmitted primarily by Aedes mosquitoes. ZIKV can be transmitted to humans by non-vector borne mechanisms such as sexual intercourse, maternal-foetal transmission or blood transfusion. In 2015, ZIKV emerged in the Americas, and spread to 87 countries and territories with autochthonous transmission, distributed across four of the six WHO regions. Read More

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Acute necrotizing encephalopathy in a child secondary to dengue fever: A case report.

Med J Malaysia 2021 Sep;76(5):750-752

Hospital Queen Elizabeth, Department of Internal Medicine, Neurology Unit, Kota Kinabalu, Sabah, Malaysia.

Dengue fever (DF) is an important public health problem, and it is now endemic in more than 100 countries worldwide. Dengue associated neurological complication is estimated to be affecting 0.5 to 6. Read More

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September 2021

Suppressing mosquito populations with precision guided sterile males.

Nat Commun 2021 Sep 10;12(1):5374. Epub 2021 Sep 10.

Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA, USA.

The mosquito Aedes aegypti is the principal vector for arboviruses including dengue/yellow fever, chikungunya, and Zika virus, infecting hundreds of millions of people annually. Unfortunately, traditional control methodologies are insufficient, so innovative control methods are needed. To complement existing measures, here we develop a molecular genetic control system termed precision-guided sterile insect technique (pgSIT) in Aedes aegypti. Read More

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September 2021

Coinfection with dengue and hepatitis A complicated with infective endocarditis in a Yemeni patient: a case report.

J Med Case Rep 2021 Sep 11;15(1):450. Epub 2021 Sep 11.

University of Science and Technology Hospital, Sana'a, Yemen.

Introduction: Coinfection with dengue and hepatitis A is rare and challenging for physicians since their clinical features can be overlapping. These infections are self-limiting but can become complicated by subsequent infective endocarditis. We report a case of infective endocarditis following a coinfection with dengue and hepatitis A. Read More

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September 2021

Cardiac evaluation in adults with dengue virus infection by serial echocardiography.

BMC Infect Dis 2021 Sep 10;21(1):940. Epub 2021 Sep 10.

Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.

Background: Dengue virus infection (DVI) is a major health problem in many parts of the world. Its manifestations range from asymptomatic infections to severe disease. Although cardiac involvement has been reported in DVI, its incidence has not yet been well established. Read More

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September 2021

Dengue pre-vaccination screening test evaluation for the use of dengue vaccine in an endemic area.

PLoS One 2021 10;16(9):e0257182. Epub 2021 Sep 10.

Excellence Center for Critical Care Nephrology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand.

Background: The dengue vaccine (Dengvaxia) is only recommended for individuals with prior dengue infection (PDI). This study aimed to perform a serosurvey to inform decision-making for vaccine introduction and identify appropriate target populations. We also evaluated the performance of the serological tests using plaque reduction neutralization test (PRNT) as a reference test in identifying PDI to determine suitability for pre-vaccination screening. Read More

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September 2021

Dabrafenib, idelalisib and nintedanib act as significant allosteric modulator for dengue NS3 protease.

PLoS One 2021 10;16(9):e0257206. Epub 2021 Sep 10.

Structural Biology and Bioinformatics Division, Indian Institute of Chemical Biology, Council of Scientific and Industrial Research, Kolkata, West Bengal, India.

Dengue virus (DENV) encodes a unique protease (NS3/NS2B) essential for its maturation and infectivity and, it has become a key target for anti-viral drug design to treat dengue and other flavivirus related infections. Present investigation established that some of the drug molecules currently used mainly in cancer treatment are susceptible to bind non-active site (allosteric site/ cavity) of the NS3 protease enzyme of dengue virus. Computational screening and molecular docking analysis found that dabrafenib, idelalisib and nintedanib can bind at the allosteric site of the enzyme. Read More

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September 2021

Host-seeking behavior and fecundity of the female Aedes aegypti to human blood types.

Pest Manag Sci 2021 Sep 10. Epub 2021 Sep 10.

Institute of Apicultural Research/Key Laboratory of Pollinating Insect Biology, Ministry of Agriculture, Chinese Academy of Agricultural Sciences, Beijing, 100093, China.

Background: Mosquitoes express different degrees of preference towards hosts depending on behavioral, ecological, and physiological factors. These preferences have implications for mosquito-borne disease risk. This study investigated the effect of human blood groups on the behavior and fecundity of the female Aedes aegypti (Diptera: Culicidae) from March 2018 to August 2019. Read More

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September 2021

Case report: Primary hemophagocytic syndrome triggered by dengue infection.

IDCases 2021 31;26:e01275. Epub 2021 Aug 31.

Department of Pathology and Laboratory Medicine/Oncology, Aga Khan University, Karachi, Pakistan.

HLH is a progressive syndrome of unchecked immune activation and tissue damage. If left untreated, patients with HLH survive for only a few months, due to progressive multi-organ failure. Prompt initiation of treatment for HLH is essential for the survival of affected patients. Read More

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Guiding Documents for Disaster Risk Reduction and Management in Health Care System of Nepal.

JNMA J Nepal Med Assoc 2020 Oct 15;58(230):831-833. Epub 2020 Oct 15.

Department of General Practice and Emergency Medicine, Patan Academy of Health Sciences, Lagankhel, Lalitpur, Nepal.

The incidence of disaster events has increased over the years. Nepal is vulnerable to various kinds of natural disasters especially earthquakes and floods and infectious disease outbreaks like Dengue and Covid-19 pneumonia. So, it is important to review and know our existing disaster risk reduction and management plans, rules, and regulations of our country to improve disaster risk management for resilience and enhancing disaster preparedness for effective response and to “Build Back Better: in recovery rehabilitation and reconstruction. Read More

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October 2020

Competitive ELISA for a serologic test to detect dengue serotype-specific anti-NS1 IgGs using high-affinity UB-DNA aptamers.

Sci Rep 2021 Sep 9;11(1):18000. Epub 2021 Sep 9.

Institute of Bioengineering and Bioimaging, 31 Biopolis Way, The Nanos, #07-01, Singapore, 138669, Singapore.

Serologic tests to detect specific IgGs to antigens related to viral infections are urgently needed for diagnostics and therapeutics. We present a diagnostic method for serotype-specific IgG identification of dengue infection by a competitive enzyme-linked immunosorbent assay (ELISA), using high-affinity unnatural-base-containing DNA (UB-DNA) aptamers that recognize the four categorized serotypes. Using UB-DNA aptamers specific to each serotype of dengue NS1 proteins (DEN-NS1), we developed our aptamer-antibody sandwich ELISA for dengue diagnostics. Read More

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September 2021

Development and Comparison of Dengue Vulnerability Indices Using GIS-Based Multi-Criteria Decision Analysis in Lao PDR and Thailand.

Int J Environ Res Public Health 2021 Sep 6;18(17). Epub 2021 Sep 6.

Department of Microbiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.

Dengue is a continuous health burden in Laos and Thailand. We assessed and mapped dengue vulnerability in selected provinces of Laos and Thailand using multi-criteria decision approaches. An ecohealth framework was used to develop dengue vulnerability indices (DVIs) that explain links between population, social and physical environments, and health to identify exposure, susceptibility, and adaptive capacity indicators. Read More

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September 2021

The immature platelet fraction, a predictive tool for early recovery from dengue-related thrombocytopenia: a prospective study.

Trans R Soc Trop Med Hyg 2021 Sep 9. Epub 2021 Sep 9.

Department of Haematology - Oncology, National University Cancer Institute, National University Health System Singapore, 5 Lower Kent Ridge Road 119074, Singapore.

Background: There is a paucity of predictive factors for early recovery from thrombocytopenia related to dengue. The immature platelet fraction (IPF%) is reflective of megakaryopoiesis and may correlate with recovery from dengue-related thrombocytopenia. Our objective was to assess the predictive value of IPF% on days 2 and 3 of illness for recovery from dengue-related thrombocytopenia. Read More

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September 2021

The association between tropical cyclones and dengue fever in the Pearl River Delta, China during 2013-2018: A time-stratified case-crossover study Tropical cyclones and dengue fever.

PLoS Negl Trop Dis 2021 Sep 9;15(9):e0009776. Epub 2021 Sep 9.

Department of Epidemiology, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Studies have shown that tropical cyclones are associated with several infectious diseases, while very few evidence has demonstrated the relationship between tropical cyclones and dengue fever. This study aimed to examine the potential impact of tropical cyclones on dengue fever incidence in the Pearl River Delta, China.

Methods: Data on daily dengue fever incidence, occurrence of tropical cyclones and meteorological factors were collected between June and October, 2013-2018 from nine cities in the Pearl River Delta. Read More

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September 2021