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    Characterization of recent and minimally passaged Brazilian dengue viruses inducing robust infection in rhesus macaques.
    PLoS One 2018 25;13(4):e0196311. Epub 2018 Apr 25.
    GSK, Rixensart, Belgium.
    The macaque is widely accepted as a suitable model for preclinical characterization of dengue vaccine candidates. However, the only vaccine for which both preclinical and clinical efficacy results were reported so far showed efficacy levels that were substantially different between macaques and humans. We hypothesized that this model's predictive capacity may be improved using recent and minimally passaged dengue virus isolates, and by assessing vaccine efficacy by characterizing not only the post-dengue virus challenge viremia/RNAemia but also the associated-cytokine profile. Read More

    Data quality and timeliness of outbreak reporting system among countries in Greater Mekong subregion: Challenges for international data sharing.
    PLoS Negl Trop Dis 2018 Apr 25;12(4):e0006425. Epub 2018 Apr 25.
    Mekong Basin Disease Surveillance Foundation, Nonthaburi, Thailand.
    Cross-border disease transmission is a key challenge for prevention and control of outbreaks. Variation in surveillance structure and national guidelines used in different countries can affect their data quality and the timeliness of outbreak reports. This study aimed to evaluate timeliness and data quality of national outbreak reporting for four countries in the Mekong Basin Disease Surveillance network (MBDS). Read More

    Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein.
    PLoS Negl Trop Dis 2018 Apr 25;12(4):e0006443. Epub 2018 Apr 25.
    W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, United States of America.
    Dengue virus (DENV) is the most prevalent and burdensome arbovirus transmitted by Aedes mosquitoes, against which there is only a limited licensed vaccine and no approved drug treatment. A Chromobacterium species, C. sp. Read More

    Quantum dot-PNA conjugates for target-catalyzed RNA detection.
    Bioconjug Chem 2018 Apr 25. Epub 2018 Apr 25.
    Detection of pathogenic nucleic acids remains one of the most reliable approaches for the diagnosis of a broad range of diseases. Current PCR-based methods require experienced personnel and cannot be easily used for point-of-care diagnostics, making alternative strategies for the sensitive, reliable, and cost-efficient detection of pathogenic nucleic acids highly desirable. Here, we report an enzyme-free method for the fluorometric detection of RNA that relies on a target-induced fluorophore transfer onto a semiconductor quantum dot (QD), uses PNA probes as selective recognition elements and can be readout with simple and inexpensive equipment. Read More

    Genome-Wide Analysis to Identify HLA Factors Potentially Associated With Severe Dengue.
    Front Immunol 2018 10;9:728. Epub 2018 Apr 10.
    Regional Virology Laboratory, Department of Microbiology, All India Institute of Medical Sciences Bhopal, Bhopal, India.
    The pathogenesis of dengue hemorrhagic fever (DHF), following dengue virus (DENV) infection, is a complex and poorly understood phenomenon. In view of the clinical need of identifying patients with higher likelihood of developing this severe outcome, we undertook a comparative genome-wide association analysis of epitope variants from sequences available in the ViPR database that have been reported to be differentially related to dengue fever and DHF. Having enumerated the incriminated epitope variants, we determined the corresponding HLA alleles in the context of which DENV infection could potentially precipitate DHF. Read More

    Effect of introduction of single-donor apheresis platelets in dengue management: A comparative analysis of two consecutive dengue epidemics.
    J Lab Physicians 2018 Apr-Jun;10(2):173-178
    Department of Community Medicine, Gian Sagar Medical College and Hospital, Patiala, Punjab, India.
    Background: The frequency of dengue outbreak is increasing in Southeast Asian countries these days and since there are no specific drugs against the dengue virus; therefore, treatment consists of mainly symptomatic and supportive care.

    Aims: Platelet transfusion forms one of the major parts of treatment therapy in dengue; therefore, this study was initiated to elicit the effect of introduction of single-donor apheresis platelets (SDAPs) in dengue management.

    Settings And Design: This is a retrospective study conducted on 622 clinically suspected cases of dengue infection who received platelet transfusions between August 2013 and December 2015 in a teaching hospital of North India. Read More

    Estimating the Risk of Vertical Transmission of Dengue: A Prospective Study.
    Am J Trop Med Hyg 2018 Apr 23. Epub 2018 Apr 23.
    Service de gynécologie et d'obstétrique, Centre Hospitalier de l'Ouest Guyanais, Saint Laurent du Maroni, French Guiana, France.
    The incidence of dengue worldwide is increasing rapidly. A better understanding of dengue transmission may help improve interventions against this major public health problem. The virus is mostly transmitted by vectors. Read More

    Isatin derivatives and their antiviral properties against arboviruses, a Review.
    Mini Rev Med Chem 2018 Apr 23. Epub 2018 Apr 23.
    Universidade Federal de Pernambuco - Departamento de Ciencias Farmaceuticas Recife, Pernambuco. Brazil.
    Arboviruses have been spreading rapidly throughout the Western Hemisphere in recent decades. Among the arboviruses with high morbidity and mortality are members of the Alphavirus and Flavivirus genera. Within the first genus, Chikungunya virus (CHIKV) is considered one of the most challenging human arboviral infections with global significance and without any specific antiviral agent. Read More

    Definitions for warning signs and signs of severe dengue according to the WHO 2009 classification: Systematic review of literature.
    Rev Med Virol 2018 Apr 24:e1979. Epub 2018 Apr 24.
    Evidence Based Medicine Research Group & Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
    Since warning signs and signs of severe dengue are defined differently between studies, we conducted a systematic review on how researchers defined these signs. We conducted an electronic search in Scopus to identify relevant articles, using key words including dengue, "warning signs," "severe dengue," and "classification." A total of 491 articles were identified through this search strategy and were subsequently screened by 2 independent reviewers for definitions of any of the warning or severe signs in the 2009 WHO dengue classification. Read More

    Neurotropism and behavioral changes associated with Zika infection in the vector Aedes aegypti.
    Emerg Microbes Infect 2018 Apr 25;7(1):68. Epub 2018 Apr 25.
    CSIRO Health and Biosecurity, Australian Animal Health Laboratory, Geelong, Australia.
    Understanding Zika virus infection dynamics is essential, as its recent emergence revealed possible devastating neuropathologies in humans, thus causing a major threat to public health worldwide. Recent research allowed breakthrough in our understanding of the virus and host pathogenesis; however, little is known on its impact on its main vector, Aedes aegypti. Here we show how Zika virus targets Aedes aegypti's neurons and induces changes in its behavior. Read More

    A forecasting model for dengue incidence in the District of Gampaha, Sri Lanka.
    Parasit Vectors 2018 Apr 24;11(1):262. Epub 2018 Apr 24.
    Molecular Medicine Unit, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka.
    Background: Dengue is one of the major health problems in Sri Lanka causing an enormous social and economic burden to the country. An accurate early warning system can enhance the efficiency of preventive measures. The aim of the study was to develop and validate a simple accurate forecasting model for the District of Gampaha, Sri Lanka. Read More

    History, epidemiology and diagnostics of dengue in the American and Brazilian contexts: a review.
    Parasit Vectors 2018 Apr 24;11(1):264. Epub 2018 Apr 24.
    Departamento de Bioquímica, Instituto de Química, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ,, 21941-909, Brazil.
    Dengue virus (DENV), an arbovirus transmitted by mosquitoes, has become a major threat to American human life, reaching approximately 23 million cases from 1980 to 2017. Brazil is among the countries most affected by this terrible viral disease, with 13.6 million cases. Read More

    The Social and Spatial Ecology of Dengue Presence and Burden during an Outbreak in Guayaquil, Ecuador, 2012.
    Int J Environ Res Public Health 2018 Apr 23;15(4). Epub 2018 Apr 23.
    Quantitative Disease Ecology and Conservation Lab, Department of Geography, University of Florida, Gainesville, FL 32611 USA.
    Dengue fever, a mosquito-borne arbovirus, is a major public health concern in Ecuador. In this study, we aimed to describe the spatial distribution of dengue risk and identify local social-ecological factors associated with an outbreak of dengue fever in the city of Guayaquil, Ecuador. We examined georeferenced dengue cases ( = 4248) and block-level census data variables to identify social-ecological risk factors associated with the presence/absence and burden of dengue in Guayaquil in 2012. Read More

    piRNA Profiling of Dengue Virus Type 2-Infected Asian Tiger Mosquito and Midgut Tissues.
    Viruses 2018 Apr 22;10(4). Epub 2018 Apr 22.
    Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Pathogen Biology, School of Public Health, Southern Medical University, Guangzhou 510515, Guangdong, China.
    The Asian tiger mosquito, , is a competent vector for the majority of arboviruses. The mosquito innate immune response is a primary determinant for arthropod-borne virus transmission, and the midgut is the first barrier to pathogen transmission. Mosquito antiviral immunity is primarily mediated by the small interfering RNA pathway. Read More

    Detection of the Invasive Mosquito Species () (Diptera: Culicidae) in Portugal.
    Int J Environ Res Public Health 2018 Apr 21;15(4). Epub 2018 Apr 21.
    National Institute of Health Doutor Ricardo Jorge, Centre for Vectors and Infectious Diseases Research, Avenida da Liberdade 5, 2965-575 Águas de Moura, Portugal.
    The Asian tiger mosquito is an invasive mosquito originating from the Asia-Pacific region. This species is of major concern to public and veterinary health because of its vector role in the transmission of several pathogens, such as chikungunya, dengue, and Zika viruses. In Portugal, a National Vector Surveillance Network (REde de VIgilância de VEctores—REVIVE) is responsible for the surveillance of autochthonous, but also invasive, mosquito species at points of entry, such as airports, ports, storage areas, and specific border regions with Spain. Read More

    The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), a vector of dengue, chikungunya and zika viruses, reaches Portugal (Diptera: Culicidae).
    Zootaxa 2018 Apr 20;4413(1):197-200. Epub 2018 Apr 20.
    Computational Biology and Population Genomics Group, cE3c - Centre for Ecology, Evolution and Environmental Changes, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, 1749-016 Lisboa, Portugal..
    The Asian tiger mosquito, Aedes (Stegomyia) albopictus (Skuse), is a tropical species originally from south-eastern Asia (Hawley, 1988). It has experienced a rampant human-mediated range expansion since the 1970s to now occupy almost the whole of the tropical and subtropical areas of the world. As an eclectic haematophagous species, it attacks humans and is able to use a number of man-made and natural structures where stagnant water is present (Estrada-Franco Craig, 1995). Read More

    Pathogen-insect interaction candidate molecules for transmission-blocking control strategies of vector borne diseases.
    Salud Publica Mex 2018 Jan-Feb;60(1):77-85
    Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México.
    Objective: To analyze the current knowledge of pathogen-insect interactions amenable for the design of molecular-based control strategies of vector-borne diseases.

    Materials And Methods: We examined malaria, dengue, and Chagas disease pathogens and insect molecules that participate in interactions during their vectors infection.

    Results: Pathogen molecules that participate in the insect intestine invasion and induced vector immune molecules are presented, and their inclusion in transmission blocking vaccines (TBV) and in genetically modify insect (GMI) vectors or symbiotic bacteria are discussed. Read More

    Dengue virus infection induces chromatin remodeling at locus AAEL006536 in the midgut of Aedes aegypti.
    Salud Publica Mex 2018 Jan-Feb;60(1):41-47
    Departamento de Infección e Inmunidad, Centro de Investigación sobre Enfermedades Infecciosas, Instituto Nacional de Salud Pública. México.
    Objective: To identify and characterize Aedes aegypti's AAEL006536 gene proximal upstream cis-regulatory sequences activated by dengue virus infection.

    Materials And Methods: A. aegypti Rockefeller strain mosquitoes were blood fed or infected with dengue virus 2. Read More

    Association of dengue fever with Aedes spp. abundance and climatological effects.
    Salud Publica Mex 2018 Jan-Feb;60(1):12-20
    Centro de Información para Decisiones en Salud Pública, Instituto Nacional de Salud Pública. Cuernavaca, Morelos, México.
    Objective: To analyze the association of dengue fever incidence with Aedes mosquito's abundance, and the effect of climatological and geographical variables, in a region in Morelos State, Mexico.

    Materials And Methods: Weekly data during the period 2010 to 2014 was used. Mosquito abundance was determined using ovitraps. Read More

    The changing epidemiological pattern of Dengue in Swat, Khyber Pakhtunkhwa.
    PLoS One 2018 24;13(4):e0195706. Epub 2018 Apr 24.
    Department of Biotechnology & Bioinformatics, Islamic International University Islamabad, Pakistan.
    Background: Pakistan is suffering from dengue fever since 1994. In the country, major dengue outbreaks have been documented in 2010, 2011 and 2013 in Punjab (Lahore) and Sindh (Karachi) Provinces. District Swat was hit for the first time by dengue virus in 2013, claiming 57 deaths and 8000 morbidities. Read More

    Why Funding for Neglected Tropical Diseases Should be a Global Priority.
    Clin Infect Dis 2018 Apr 24. Epub 2018 Apr 24.
    Skaggs School of Pharmacy and Pharmaceutical Science UCSD.
    Neglected Tropical Diseases affect more than 1 billion of the world's poorest people. Control programs range from near elimination (dracunculiasis) to increasing prevalence (dengue and cutaneous leishmaniasis). These are some of the most cost-effective public health interventions in the world and should be a global priority. Read More

    SIRT6 Acts as a Negative Regulator in Dengue Virus-Induced Inflammatory Response by Targeting the DNA Binding Domain of NF-κB p65.
    Front Cell Infect Microbiol 2018 9;8:113. Epub 2018 Apr 9.
    Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China.
    Dengue virus (DENV) is a mosquito-borne single-stranded RNA virus causing human disease with variable severity. The production of massive inflammatory cytokines in dengue patients has been associated with dengue disease severity. However, the regulation of these inflammatory responses remains unclear. Read More

    The Autoimmune Mechanism in Dengue Hemorrhagic Fever.
    Acta Med Indones 2018 Jan;50(1):70-79
    Department of Internal Medicine, Gatot Soebroto Central Army Hospital-Jakarta, Indonesia.
    The immune response of dengue fever/dengue hemorrhagic fever is a series of immunopathogenesis processes starting from viral infection to the target on monocytes and macrophages. It may consequently cause a cascade of viremia in the circulation that stimulates the afferent, efferent, and effector mechanism by the interaction of the humoral and complement system. The cascade results in inflammatory substance that will affect capillary permeability and activate coagulation factors leading to further effects on endothelial level. Read More

    The redox-sensing gene Nrf2 affects intestinal homeostasis, insecticide resistance and Zika virus susceptibility in the mosquito Aedes aegypti.
    J Biol Chem 2018 Apr 23. Epub 2018 Apr 23.
    Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Brazil.
    Production and degradation of reactive oxygen species (ROS) are extensively regulated to ensure proper cellular responses to various environmental stimuli and stresses. Moreover, physiologically generated ROS function as secondary messengers that can influence tissue homeostasis. The cap'n'collar transcription factor known as nuclear factor erythroid-derived factor 2 (Nrf2) coordinates an evolutionarily conserved transcriptional activation pathway that mediates antioxidant and detoxification responses in many animal species, including insects and mammals. Read More

    Ebolavirus diagnosis made simple, comparable and faster than molecular detection methods: preparing for the future.
    Virol J 2018 Apr 23;15(1):75. Epub 2018 Apr 23.
    Genecology Research Centre, School of Science and Engineering, University of the Sunshine Coast, Sippy Downs, QLD, Australia.
    Background: The 2014/2015 Ebolavirus outbreak resulted in more than 28,000 cases and 11,323 reported deaths, as of March 2016. Domestic transmission of the Guinea strain associated with the outbreak occurred mainly in six African countries, and international transmission was reported in four countries. Outbreak management was limited by the inability to rapidly diagnose infected cases. Read More

    Development of antibody biomarkers of long term and recent dengue virus infections.
    J Virol Methods 2018 Apr 20. Epub 2018 Apr 20.
    Graduate School of Public Health and Center for Vaccine Research, University of Pittsburgh, Biomedical Science Tower 3, room 9052, 3501 5th Avenue, Pittsburgh, PA 15261, USA; Aggeu Magalhaes Institute, Oswaldo Cruz Foundation (FIOCRUZ), Av. Prof. Moraes Rego, s/n - Cidade Universitária - Campus da UFPE, CEP: 50.740-465, Recife, Pernambuco, Brazil. Electronic address:
    Dengue virus (DENV) infections elicit antibody responses to the non-structural protein 1 (NS1) that are associated with protection against disease. However, the antibody isotypes and subclasses involved, and their kinetics have not been extensively studied. We characterized the antibody responses to DENV NS1 by enzyme-linked immunosorbent assay (ELISA) in a longitudinal cohort of 266 confirmed dengue cases in Recife, Northeast Brazil. Read More

    Seroprevalence of Dengue Virus, West Nile Virus, Chikungunya Virus, and Zika Virus in International Travelers Attending a Travel and Migration Center in 2015-2017, Southern Italy.
    Vector Borne Zoonotic Dis 2018 Apr 23. Epub 2018 Apr 23.
    Section of Hygiene, Department of Biomedical Sciences and Human Oncology, University of Bari , Bari, Italy .
    International travelers to areas endemic for vector-borne diseases (VBDs) may be at risk of contracting and spreading these diseases. The aim of this study was to evaluate the prevalence of immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies that are specific for Dengue Virus (DV), West Nile Virus (WNV), Chikungunya Virus (CHIKV), or Zika Virus (ZV) in a cohort of international travelers. The study enrolled travelers who attended the Travel Medicine and Migration outpatient service of Local Health Unit of Bari, Italy, in March 2015-June 2017 for counseling and vaccine prophylaxis before travel. Read More

    Subverting the mechanisms of cell death: flavivirus manipulation of host cell responses to infection.
    Biochem Soc Trans 2018 Apr 20. Epub 2018 Apr 20.
    Department of Biochemistry, IIB, University of Liverpool, Crown Street, Liverpool L69 7ZB, U.K.
    Viruses exploit host metabolic and defence machinery for their own replication. The flaviviruses, which include Dengue (DENV), Yellow Fever (YFV), Japanese Encephalitis (JEV), West Nile (WNV) and Zika (ZIKV) viruses, infect a broad range of hosts, cells and tissues. Flaviviruses are largely transmitted by mosquito bites and humans are usually incidental, dead-end hosts, with the notable exceptions of YFV, DENV and ZIKV. Read More

    Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins.
    J Biol Chem 2018 Apr 20. Epub 2018 Apr 20.
    University of North Carolina, United States.
    The spread of dengue (DENV) and Zika virus (ZIKV) is a major public health concern. The primary target of antibodies (Abs) that neutralize DENV and ZIKV is the envelope (E) glycoprotein, and there is interest in using soluble recombinant E (sRecE) proteins as subunit vaccines. However, the most potent neutralizing antibodies against DENV and ZIKV recognize epitopes on the virion surface that span two or more E proteins. Read More

    Validity of International Classification of Diseases (ICD) coding for dengue infections in hospital discharge records in Malaysia.
    BMC Health Serv Res 2018 Apr 20;18(1):292. Epub 2018 Apr 20.
    Clin Research Sdn Bhd, D7-3-1, Block D7, Pusat Perdagangan Dana 1, Jalan PJU 1A/46, PJU 1A, 47301, Petaling Jaya, Selangor, Malaysia.
    Background: Hospitalization due to dengue illness is an important measure of dengue morbidity. However, limited studies are based on administrative database because the validity of the diagnosis codes is unknown. We validated the International Classification of Diseases, 10th revision (ICD) diagnosis coding for dengue infections in the Malaysian Ministry of Health's (MOH) hospital discharge database. Read More

    Raman spectral analysis for rapid screening of dengue infection.
    Spectrochim Acta A Mol Biomol Spectrosc 2018 Apr 11;200:136-142. Epub 2018 Apr 11.
    FOCAS Research Institute, Dublin Institute of Technology, Kevin Street, Dublin 8, Ireland.
    Infection with the dengue virus is currently clinically detected according to different biomarkers in human blood plasma, commonly measured by enzyme linked immunosorbent assays, including non-structural proteins (Ns1), immunoglobulin M (IgM) and immunoglobulin G (IgG). However, there is little or no mutual correlation between the biomarkers, as demonstrated in this study by a comparison of their levels in samples from 17 patients. As an alternative, the label free, rapid screening technique, Raman spectroscopy has been used for the characterisation/diagnosis of healthy and dengue infected human blood plasma samples. Read More

    Allosteric ligands for the pharmacologically important Flavivirus target (NS5) from ZINC database based on pharmacophoric points, free energy calculations and dynamics correlation.
    J Mol Graph Model 2018 Apr 11;82:37-47. Epub 2018 Apr 11.
    State Key Laboratory of Microbial Metabolism and College of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China. Electronic address:
    Dengue virus belongs to a group of human pathogens, which causes different diseases, dengue hemorrhagic fever and dengue shock syndrome in humans. It possesses RNA as a genetic material and is replicated with the aid of NS5 protein. RNA-dependent RNA polymerase (RdRp) is an important domain of NS5 in the replication of that virus. Read More

    Dengue virus NS2 and NS4: minor proteins, mammoth roles.
    Biochem Pharmacol 2018 Apr 16. Epub 2018 Apr 16.
    Department of Biotechnology, Sri Jayachamarajendra College of Engineering, JSS Science and Technology University, JSS TEI Campus, Mysuru 57006, Karnataka, India. Electronic address:
    Despite the ever increasing global incidence of dengue fever, there are no specific chemotherapy regimens for its treatment. Structural studies on dengue virus (DENV) proteins have revealed potential drug targets. Major DENV proteins such as the envelope protein and non-structural (NS) proteins 3 and 5 have been extensively investigated in antiviral studies, but with limited success in vitro. Read More

    Population genetics-informed meta-analysis in seven genes associated with risk to dengue fever disease.
    Infect Genet Evol 2018 Apr 17;62:60-72. Epub 2018 Apr 17.
    i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal; Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), 4200-135 Porto, Portugal; Faculdade de Medicina da Universidade do Porto, Portugal. Electronic address:
    Population genetics theory predicted that rare frequent markers would be the main contributors for heritability of complex diseases, but meta-analyses of genome-wide association studies are revealing otherwise common markers, present in all population groups, as the identified candidate genes. In this work, we applied a population-genetics informed meta-analysis to 10 markers located in seven genes said to be associated with dengue fever disease. Seven markers (in PLCE1, CD32, CD209, OAS1 and OAS3 genes) have high-frequency and the other three (in MICB and TNFA genes) have intermediate frequency. Read More

    Structure activity relationship (SAR) and quantitative structure activity relationship (QSAR) studies showed plant flavonoids as potential inhibitors of dengue NS2B-NS3 protease.
    BMC Struct Biol 2018 Apr 19;18(1). Epub 2018 Apr 19.
    Virology Lab, Centre of Agricultural Biochemistry and Biotechnology, University of Agriculture, Jail road, Faisalabad, 38000, Pakistan.
    Background: Due to dengue virus disease, half of the world population is at severe health risk. Viral encoded NS2B-NS3 protease complex causes cleavage in the nonstructural region of the viral polyprotein. The cleavage is essentially required for fully functional viral protein. Read More

    Dengue Fever and Aedes aegypti in Indigenous Brazilians: seroprevalence, risk factors, knowledge and practices.
    Trop Med Int Health 2018 Apr 19. Epub 2018 Apr 19.
    Federal University of Ceará, Fortaleza, Ceará, Brazil.
    Objective: Dengue remains an important public health problem in Brazil. We estimated the associated factors of dengue seroprevalence among native Indians of the Tremembé ethnic and their knowledge about the aspects related to the presence of mosquitoes of the genus Aedes.

    Methods: An analytical cross-sectional study and a prospective environmental study to monitor the trapping of mosquito eggs monthly were performed. Read More

    Dengue virus not detected in human semen.
    J Travel Med 2018 Jan;25(1)
    Travellers' Health & Vaccination Clinic, Tan Tock Seng Hospital, Singapore.
    Zika and Ebola viruses can persist in semen and pose a risk for sexual transmission. To determine if dengue virus, another flavivirus, is similarly detectable in semen, we performed dengue PCR on semen in five patients with acute dengue virus infection. All five tested negative, suggesting that dengue does not pose a risk for sexual transmission. Read More

    Surveillance of travel-associated diseases at two referral centres in Marseille, France: a 12-year survey.
    J Travel Med 2018 Jan;25(1)
    Aix Marseille Univ, IRD, AP-HM, SSA, VITROME, IHU-Méditerranée Infection, Marseille, France.
    Background: With increasing international travel and historically high numbers of residents visiting friends and relatives overseas, travel-associated illnesses are frequent in Marseille, France. We report the changing epidemiology of travel-related illnesses over a 12-year period.

    Methods: A single site GeoSentinel surveillance analysis was undertaken for 3460 ill returned travellers presenting to two public hospitals in Marseille, France from March 2003 to October 2015, with travel-related illnesses. Read More

    Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis.
    PLoS Negl Trop Dis 2018 Apr 19;12(4):e0006421. Epub 2018 Apr 19.
    Center for Drug Design, Academic Health Center, University of Minnesota, Minneapolis, Minnesota, United States of America.
    Dengue virus affects millions of people worldwide each year. To date, there is no drug for the treatment of dengue-associated disease. Nucleosides are effective antivirals and work by inhibiting the accurate replication of the viral genome. Read More

    A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica.
    Phytother Res 2018 Apr 19. Epub 2018 Apr 19.
    Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Aljouf, Sakakah, 2014, Saudi Arabia.
    Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Read More

    Spatiotemporal Distribution and Geospatial Diffusion Patterns of 2013 Dengue Outbreak in Jhapa District, Nepal.
    Asia Pac J Public Health 2018 Apr 1:1010539518769809. Epub 2018 Apr 1.
    3 Kanti Children's Hospital Maharajgunj, Kathmandu, Nepal.
    This study describes spatiotemporal distribution and geospatial diffusion patterns of dengue outbreak of 2013 in Jhapa district, Nepal. Laboratory-confirmed dengue cases were collected from the District Public Health Office, Government of Nepal. Choropleth mapping technique, Global Moran's Index, SaTScan, and standard deviational ellipse were used to map and quantify the outbreak dynamics. Read More

    Susceptibility Status and Resistance Mechanisms in Permethrin-Selected, Laboratory Susceptible and Field-Collected Aedes aegypti from Malaysia.
    Insects 2018 Apr 18;9(2). Epub 2018 Apr 18.
    State Key Laboratory for Infectious Diseases Prevention and Control, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
    This study is intended to provide a comprehensive characterization of the resistance mechanisms in the permethrin-selected (IMR-PSS) and laboratory susceptible (IMR-LS) strain from Malaysia. Both IMR-PSS and IMR-LS provide a standard model for use in assessing the pyrethroid resistance in field-collected strains collected from three dengue hotspots: the Taman Seri Bayu (TSB), the Flat Camar (FC), and the Taman Dahlia (TD). Two established methods for determining the resistance mechanisms of the pyrethroid are the quantification of detoxification enzymes via enzyme microassay and the nucleotide sequencing of the domain 2 region from segment 1 to 6 via classical polymerase chain reaction (PCR) amplification-were employed. Read More

    Cerebral vasculitis and lateral rectus palsy - two rare central nervous system complications of dengue fever: two case reports and review of the literature.
    J Med Case Rep 2018 Apr 19;12(1):100. Epub 2018 Apr 19.
    Department of Microbiology, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
    Background: Dengue fever is a common mosquito-borne viral illness with a clinical spectrum ranging from a simple febrile illness to potentially life-threatening complications such as dengue hemorrhagic fever and dengue shock syndrome. Dengue infection can affect many organs, including the central nervous system. The neurological manifestations reported in dengue infections are meningitis, encephalitis, stroke, acute disseminated encephalomyelitis, and Guillain-Barré syndrome. Read More

    The Immune Responses of the Animal Hosts of West Nile Virus: A Comparison of Insects, Birds, and Mammals.
    Front Cell Infect Microbiol 2018 3;8:96. Epub 2018 Apr 3.
    School of Molecular Biosciences, Washington State University, Pullman, WA, United States.
    Vector-borne diseases, including arboviruses, pose a serious threat to public health worldwide. Arboviruses of the flavivirus genus, such as Zika virus (ZIKV), dengue virus, yellow fever virus (YFV), and West Nile virus (WNV), are transmitted to humans from insect vectors and can cause serious disease. In 2017, over 2,000 reported cases of WNV virus infection occurred in the United States, with two-thirds of cases classified as neuroinvasive. Read More

    Phylogenetic Analysis of Dengue Virus in Bangkalan, Madura Island, East Java Province, Indonesia.
    J Trop Med 2018 15;2018:8127093. Epub 2018 Feb 15.
    Center for Infectious Diseases, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650-0017, Japan.
    Dengue virus (DENV) infection is a major health issue in tropical and subtropical areas. Indonesia is one of the biggest dengue endemic countries in the world. In the present study, the phylogenetic analysis of DENV in Bangkalan, Madura Island, Indonesia, was performed in order to obtain a clearer understanding of its dynamics in this country. Read More

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