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    1 OF 366

    Transmission scenarios of major vector-borne diseases in Colombia, 1990-2016.
    Biomedica 2017 Mar 29;37(0):27-40. Epub 2017 Mar 29.
    Programa de Prevención y Control de Enfermedades Transmitidas por Vectores, Ministerio de Salud y Protección Social, Bogotá, D.C., Colombia.
    Introducción. Las enfermedades transmitidas por vectores representan más de 17 % de todas las enfermedades infecciosas y causan anualmente un millón de defunciones a nivel mundial. En Colombia, la malaria, el dengue, la enfermedad de Chagas y las leishmaniasis son condiciones endemoepidémicas persistentes. Read More

    Wolbachia infection alters the relative abundance of resident bacteria in adult Aedes aegypti mosquitoes, but not larvae.
    Mol Ecol 2017 Nov 22. Epub 2017 Nov 22.
    School of Biological Sciences, Monash University, Clayton VIC 3800, Melbourne, Australia.
    Insect-symbiont interactions are known to play key roles in host functions and fitness. The common insect endosymbiont Wolbachia can reduce the ability of several human pathogens, including arboviruses and the malaria parasite, to replicate in insect hosts. Wolbachia does not naturally infect Aedes aegypti, the primary vector of dengue virus, but transinfected Ae. Read More

    Evidence of Chikungunya virus circulation in the Terai region of Nepal in 2014 and 2015.
    Trans R Soc Trop Med Hyg 2017 Nov 20:1-6. Epub 2017 Nov 20.
    Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.
    Background: Chikungunya virus (CHIKV) infection is an emerging viral disease in Nepal, with the reported by our laboratories in 2013. Because of the similarity in signs and symptoms to dengue virus (DENV) and misdiagnosis, the under-reporting of CHIKV infection in DENV-endemic areas of Nepal is very common. The aim of the present study is to identify CHIKV infection among patients with febrile illness during the 2014-2015 outbreaks. Read More

    NS3 helicase from dengue virus specifically recognizes viral RNA sequence to ensure optimal replication.
    Nucleic Acids Res 2017 Nov 20. Epub 2017 Nov 20.
    Program in Emerging Infectious Diseases, Duke-NUS Medical School, 8 College Road, 169857, Singapore.
    The protein-RNA interactions within the flavivirus replication complex (RC) are not fully understood. Our structure of dengue virus NS3 adenosine triphosphatase (ATPase)/helicase bound to the conserved 5' genomic RNA 5'-AGUUGUUAGUCU-3' reveals that D290 and R538 make specific interactions with G2 and G5 bases respectively. We show that single-stranded 12-mer RNA stimulates ATPase activity of NS3, however the presence of G2 and G5 leads to significantly higher activation. Read More

    Use of Bacillus thuringiensis israelensis in integrated vector control of Aedes sp. in Sri Lanka: a prospective controlled effectiveness study.
    Trop Med Int Health 2017 Nov 22. Epub 2017 Nov 22.
    Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka.
    Objectives: The annual incidence of dengue has been increasing over the last few years in Sri Lanka with seasonal epidemics. Biological control of the vector has not been part of the integrated vector control implemented by the public health authorities of Sri Lanka so far. This pilot study assessed the effectiveness of using Bacillus thuringiensis israelensis (Bti) spray to control the Aedes mosquito vector population density. Read More

    High prevalence of dengue antibodies and the arginine variant of the FcγRIIa polymorphism in asymptomatic individuals in a population of Minas Gerais State, Southeast Brazil.
    Immunogenetics 2017 Nov 21. Epub 2017 Nov 21.
    Laboratório de Vacinas, Instituto de Ciências Biomédicas, Universidade Federal de Alfenas, Rua Gabriel Monteiro, 700 Centro, Alfenas, Minas Gerais, 37130-000, Brazil.
    Dengue is the most prevalent arthropod-borne viral illness in humans worldwide. Single-nucleotide polymorphisms (SNPs) in genes involved in the immune response, such as dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN), IgG Fc receptor II-A (FcγRIIa), vitamin D receptor (VDR), and tumor necrosis factor alpha (TNF-α), were previously reported to be associated with susceptibility to dengue disease in different human populations. Therefore, due to the relevant association of host immune and genetic status with disease susceptibility/severity of dengue, this work aims to verify the frequency of anti-dengue virus antibodies and some dengue-associated risk SNPs in a population in Minas Gerais State, Southeast Brazil. Read More

    Targeting Dengue Virus NS-3 Helicase by Ligand based Pharmacophore Modeling and Structure based Virtual Screening.
    Front Chem 2017 31;5:88. Epub 2017 Oct 31.
    UoN Chair of Oman Medicinal Plants and Marine Products, University of Nizwa, Nizwa, Oman.
    Dengue fever is an emerging public health concern, with several million viral infections occur annually, for which no effective therapy currently exist. Non-structural protein 3 (NS-3) Helicase encoded by the dengue virus (DENV) is considered as a potential drug target to design new and effective drugs against dengue. Helicase is involved in unwinding of dengue RNA. Read More

    Broad-spectrum antiviral agents: secreted phospholipase A2 targets viral envelope lipid bilayers derived from the endoplasmic reticulum membrane.
    Sci Rep 2017 Nov 21;7(1):15931. Epub 2017 Nov 21.
    Department of Vaccine and Drug Development, Graduate School of Health Sciences, Kobe University, Kobe, 650-0047, Japan.
    Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The phospholipid content of the ER membrane differs from that of the plasma membrane (PM). Read More

    Controlled human infections: A report from the controlled human infection models workshop, Leiden University Medical Centre 4-6 May 2016.
    Vaccine 2017 Nov 18. Epub 2017 Nov 18.
    Leiden University Medical Centre, The Netherlands.
    The principle of deliberately infecting humans with infectious agents in a controlled setting, so-called controlled human infections (CHI), is not novel. Many CHI models have a long history and were established decades ago such as the intentional exposure to yellow fever and dengue performed in the 1900's (Reed, 1902) [2]. In these times bioethics and scientific reasoning were in their infancy. Read More

    Geraniin extracted from the rind of Nephelium lappaceum binds to dengue virus type-2 envelope protein and inhibits early stage of virus replication.
    Virol J 2017 Nov 21;14(1):229. Epub 2017 Nov 21.
    Virus-Host Interaction Research Group, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
    Background: The rapid rise and spread in dengue cases, together with the unavailability of safe vaccines and effective antiviral drugs, warrant the need to discover and develop novel anti-dengue treatments. In this study the antiviral activity of geraniin, extracted from the rind of Nephelium lappaceum, against dengue virus type-2 (DENV-2) was investigated.

    Methods: Geraniin was prepared from Nephelium lappaceum rind by reverse phase C-18 column chromatography. Read More

    Complex wolbachia infection dynamics in mosquitoes with imperfect maternal transmission.
    Math Biosci Eng 2018 Apr;15(2):523-541
    School of Mathematics and Information Science, Guangzhou University, Guangzhou 510006, China email:
    Dengue, malaria, and Zika are dangerous diseases primarily transmitted by Aedes aegypti, Aedes albopictus, and Anopheles stephensi. In the last few years, a new disease control method, besides pesticide spraying to kill mosquitoes, has been developed by releasing mosquitoes carrying bacterium Wolbachia into the natural areas to infect the wild population of mosquitoes and block disease transmission. The bacterium is transmitted by infected mothers and the maternal transmission was assumed to be perfect in virtually all previous models. Read More

    A network model for control of dengue epidemic using sterile insect technique.
    Math Biosci Eng 2018 Apr;15(2):441-460
    Normandie Univ, UNIHAVRE, LMAH, FR-CNRS-3335, ISCN, 76600 Le Havre, France email:
    In this paper, a network model has been proposed to control dengue disease transmission considering host-vector dynamics in n patches. The control of mosquitoes is performed by SIT. In SIT, the male insects are sterilized in the laboratory and released into the environment to control the number of offsprings. Read More

    Dengue virus detection in Aedes aegypti larvae and pupae collected in rural areas of Anapoima, Cundinamarca, Colombia.
    Biomedica 2017 Mar 29;37(0):193-200. Epub 2017 Mar 29.
    Grupo de Virología, Vicerrectoría de Investigaciones, Universidad El Bosque, Bogotá, D.C., Colombia.
    Introduction: There is a high incidence and prevalence of dengue in the department of Cundinamarca, and recently Aedes aegypti, the main vector of dengue virus (DENV), was detected in some of its rural areas.

    Objective: To evaluate viral transovarial transmission in larvae and pupae collected in rural areas of the municipality of Anapoima, Cundinamarca.

    Materials And Methods: Live larvae and pupae were collected from 53 homes and later they were taken to the laboratory in Anapoima, where they were classified, pooled and frozen. Read More

    Virological surveillance of Aedes (Stegomyia) aegypti and Aedes (Stegomyia) albopictus as support for decision making for dengue control in Medellín.
    Biomedica 2017 Mar 29;37(0):155-166. Epub 2017 Mar 29.
    Grupo de Entomología Médica, Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
    Introduction: Dengue represents an important public health problem in Colombia. No treatment is available and the vaccine has not been approved in all countries, hence, actions should be strengthened to mitigate its impact through the control of Aedes aegypti, the vector mosquito. In Colombia, surveillance is done using entomological indexes and case notification, which is usually informed late, leading to untimely interventions. Read More

    Aedes albopictus (Skuse, 1894) infected with the American-Asian genotype of dengue type 2 virus in Medellín suggests its possible role as vector of dengue fever in Colombia.
    Biomedica 2017 Mar 29;37(0):135-142. Epub 2017 Mar 29.
    Grupo de Investigación en Ciencias Biomédicas, Escuela de Ciencias Biológicas, Universidad Pedagógica y Tecnológica de Colombia, Tunja, Colombia.
    Introduction: Aedes aegypti and Ae. albopictus are recognized vectors of dengue, yellow fever, chikungunya and Zika arboviruses in several countries worldwide. In Colombia, Ae. Read More

    [Laboratory susceptibility tests of Aedes aegypti and Culex quinquefasciatus larvae to the entomopathogenic nematode Heterorhabditis bacteriophora].
    Biomedica 2017 Mar 29;37(0):67-76. Epub 2017 Mar 29.
    Cátedra de Parasitología, Facultad de Ciencias Exactas, Físicas y Naturales, Universidad Nacional de Córdoba, Córdoba, Argentina.
    Introduction: Aedes aegypti is the vector of dengue, yellow fever, Zika and Chikungunya viruses, and Culex quinquefasciatus is the vector of St. Louis and West Nile encephalitis viruses.

    Objective: To evaluate infectivity of Heterorhabditis bacteriophora N4 in C. Read More

    [Spatial distribution of potential and positive Aedes aegypti breeding sites].
    Biomedica 2017 Mar 29;37(0):59-66. Epub 2017 Mar 29.
    Grupo de Epidemiología y Salud Poblacional, Universidad del Valle, Cali, Colombia.
    Introduction: The spatial distribution of Aedes aegypti is heterogeneous, and the interaction between positive and potential breeding sites located both inside and outside homes is one of the most difficult aspects to characterize in vector control programs.

    Objective: To describe the spatial relationship between potential and positive breeding sites of A. aegypti inside and outside homes in Cali, Colombia. Read More

    [Spatial distribution of Aedes aegypti (Diptera: Culicidae) in the rural area of two municipalities of Cundinamarca, Colombia].
    Biomedica 2017 Mar 29;37(0):41-49. Epub 2017 Mar 29.
    Instituto de Salud y Ambiente, Universidad El Bosque, Bogotá, D.C., Colombia Facultad de Ingeniería, Universidad Distrital Francisco José de Caldas, Bogotá, D.C., Colombia.
    Introduction: It is difficult to adapt or create new strategies for dengue control in rural areas due to the dispersion of homes and the lack of knowledge about the presence and behavior of the vector in these areas. Spatial data analysis could help understand time and space dynamics related to the transmission of vector-borne diseases in rural areas and, thus, contribute to the prevention and control of dengue.

    Objective: To determine the probability of the presence of the dengue vector Aedes aegypti in the rural area of the municipalities of Anapoima and La Mesa, in the central area of Colombia. Read More

    Detection and quantification of dengue virus using a novel biosensor system based on dengue NS3 protease activity.
    PLoS One 2017 21;12(11):e0188170. Epub 2017 Nov 21.
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC.
    Background: The traditional methods, plaque assays and immuno-focus assays, used to titrate infectious dengue virus (DENV) particles are time consuming and labor intensive. Here, we developed a DENV protease activity detection system (DENPADS) to visualize DENV infection in cells based on dengue protease activity.

    Methodology/principal Findings: Dengue NS3 protease cleaves NS4B-NS5. Read More

    Cardiac tamponade in a patient with severe dengue fever.
    Rev Soc Bras Med Trop 2017 Sep-Oct;50(5):701-705
    Laboratório de Virologia e Terapia Experimental, Centro de Pesquisas Aggeu Magalhães, Fundação Oswaldo Cruz, Recife, PE, Brasil.
    A 26-year-old postpartum female presented with symptoms characteristic of dengue fever on the 16th day of puerperium. On the third day of the illness, the patient presented a clinical picture consistent with shock. Tests determined primary infection with dengue virus serotype 2. Read More

    Marmosets (Callithrix jacchus) as a non-human primate model for evaluation of candidate dengue vaccines: induction and maintenance of specific protective immunity against challenges with clinical isolates.
    J Gen Virol 2017 Nov 21. Epub 2017 Nov 21.
    7​National Institute of Infectious Diseases, Tokyo, Japan.
    Dengue virus (DENV) is one of the major infectious diseases in tropical regions and approximately half of the world population is at risk of infection. Vaccines would offer an effective control measure against this disease. We previously reported on the utility of marmosets as an animal model for studying primary and secondary dengue infections. Read More

    First complete genome sequence of circulating dengue virus serotype 3 in Jeddah, Saudi Arabia.
    New Microbes New Infect 2018 Jan 23;21:9-11. Epub 2017 Sep 23.
    Special Infectious Agent Unit, King Fahd Medical Research Center, Jeddah, Saudi Arabia.
    Here we report the first full-length genome sequence of dengue virus serotype 3 (DENV-3) from a strain isolated from a patient in Jeddah, Saudi Arabia, in 2014. The genome consists of 10 635 bp and shows close similarity to circulating genotype III isolates from Singapore, suggesting possible importation, most probably during religious pilgrimages to Saudi Arabia. Read More

    Chikungunya outbreak in Delhi, India, 2016: report on coinfection status and comorbid conditions in patients.
    New Microbes New Infect 2017 Nov 4;20:39-42. Epub 2017 Aug 4.
    Department of Medicine, VMMC & Safdarjang Hospital, New Delhi, India.
    Chikungunya fever is a major public health issue in India affecting billions. After 2010, the infection was in a decline until in 2016, when a massive outbreak affected the country. In this report, we present serologic and molecular investigations of 600 patient samples for chikungunya and dengue viruses along with clinical and comorbidity features. Read More

    Upregulation of Aedes aegypti Vago1 by Wolbachia and its effect on dengue virus replication.
    Insect Biochem Mol Biol 2017 Nov 17. Epub 2017 Nov 17.
    Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD 4072 Australia. Electronic address:
    Dengue infection along with its related disease conditions poses a significant threat to human health. The pathogen responsible for this infection is dengue virus (DENV) which is primarily transmitted to humans through the bites of Aedes aegypti mosquitoes. Unavailability of a potent vaccine has recently sparked renewed research endeavours aimed at vector control. Read More

    Discovery of selective dengue virus inhibitors using combination of molecular fingerprint-based virtual screening protocols, structure-based pharmacophore model development, molecular dynamics simulations and in vitro studies.
    J Mol Graph Model 2017 Oct 24;79:88-102. Epub 2017 Oct 24.
    Computational Biology and Molecular Simulations Laboratory, Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey.
    Dengue virus is a major issue of tropical and sub-tropical regions. The proliferation of virus results in immense number of deaths each year because of unavailability of on-shelf drugs. This issue necessitates the design of novel anti-Dengue drugs. Read More

    Robust real-time cell analysis method for determining viral infectious titers during development of a viral vaccine production process.
    J Virol Methods 2017 Nov 14. Epub 2017 Nov 14.
    Sanofi Pasteur, 1541 avenue Marcel Mérieux, 69280 Marcy l'Etoile, France. Electronic address:
    The classical cell-culture methods, such as cell culture infectious dose 50% (CCID50) assays, are time-consuming, end-point assays currently used during the development of a viral vaccine production process to measure viral infectious titers. However, they are not suitable for handling the large number of tests required for high-throughput and large-scale screening analyses. Impedance-based bio-sensing techniques used in real-time cell analysis (RTCA) to assess cell layer biological status in vitro, provide real-time data. Read More

    The antimicrobial peptide HS-1 inhibits dengue virus infection.
    Virology 2017 Nov 16;514:79-87. Epub 2017 Nov 16.
    Laboratory of Molecular Immunovirology, General Biology Department, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil. Electronic address:
    Dengue virus (DENV) is an arbovirus that belongs to the Flaviviridae family. Studies reveal that peptides secreted by amphibians have many functions, such as antiviral and antimicrobial activities. As there is no antiviral drug effective against the DENV, the antiviral activity of a synthetic peptide called HS-1, derived from the secretion of the anuran Hypsiboas semilineatus, has been evaluated. Read More

    Generation and characterization of cross neutralizing human monoclonal antibody against 4 serotypes of dengue virus without enhancing activity.
    PeerJ 2017 13;5:e4021. Epub 2017 Nov 13.
    Center of Excellence for Antibody Reserach, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
    Background: Dengue disease is a leading cause of illness and death in the tropics and subtropics. Most severe cases occur among patients secondarily infected with a different dengue virus (DENV) serotype compared with that from the first infection, resulting in antibody-dependent enhancement activity (ADE). Our previous study generated the neutralizing human monoclonal antibody, D23-1B3B9 (B3B9), targeting the first domain II of E protein, which showed strong neutralizing activity (NT) against all four DENV serotypes. Read More

    Effective population sizes of a major vector of human diseases, Aedes aegypti.
    Evol Appl 2017 Dec 3;10(10):1031-1039. Epub 2017 Sep 3.
    Yale UniversityNew HavenCTUSA.
    The effective population size (Ne ) is a fundamental parameter in population genetics that determines the relative strength of selection and random genetic drift, the effect of migration, levels of inbreeding, and linkage disequilibrium. In many cases where it has been estimated in animals, Ne is on the order of 10%-20% of the census size. In this study, we use 12 microsatellite markers and 14,888 single nucleotide polymorphisms (SNPs) to empirically estimate Ne in Aedes aegypti, the major vector of yellow fever, dengue, chikungunya, and Zika viruses. Read More

    Chikungunya Infection in Solid Organ Transplant Recipients.
    Transplant Proc 2017 Nov;49(9):2076-2081
    Kidney Transplant Unit, Hospital Universitário Walter Cantídio - Fortaleza, Ceará, Brazil; Universidade Estadual do Ceará - Fortaleza, Ceará, Brazil.
    Background: Chikungunya virus (CHIKV) is an emerging mosquito-borne disease that causes acute febrile polyarthralgia and arthritis. CHIKV has spread rapidly to the Americas and, in Brazil, autochthonous cases are increasingly been reported. Solid organ transplant (SOT) recipients who travel to or live in CHIKV endemic areas are under high risk of acquiring the disease. Read More

    Vector-borne diseases and climate change: a European perspective.
    FEMS Microbiol Lett 2017 Nov 15. Epub 2017 Nov 15.
    European Centre for Disease Prevention and Control.
    Climate change has already impacted the transmission of a wide-range of vector-borne diseases in Europe, and it will continue to do so in the coming decades. Climate change has been implicated in the observed shift of ticks to elevated altitudes and latitudes, notably including the Ixodes ricinus tick species which is a vector for Lyme borreliosis and tick-borne encephalitis. Climate change is also thought to have been a factor in the expansion of other important disease vectors in Europe: Aedes albopictus (the Asian tiger mosquito), which transmits diseases such as Zika, dengue, and chikungunya, and Phlebotomus sandfly species, which transmits diseases including Leishmaniasis. Read More

    The introduction of dengue follows transportation infrastructure changes in the state of Acre, Brazil: A network-based analysis.
    PLoS Negl Trop Dis 2017 Nov 17;11(11):e0006070. Epub 2017 Nov 17.
    Fiocruz, Programa de Computação Científica (PROCC), Rio de Janeiro, RJ, Brazil.
    Human mobility, presence and passive transportation of Aedes aegypti mosquito, and environmental characteristics are a group of factors which contribute to the success of dengue spread and establishment. To understand this process, we assess data from dengue national and municipal basins regarding population and demographics, transportation network, human mobility, and Ae. aegypti monitoring for the Brazilian state of Acre since the first recorded dengue case in the year 2000 to the year 2015. Read More

    Diagnostic Accuracy of Parameters for Zika and Dengue Virus Infections, Singapore.
    Emerg Infect Dis 2017 Dec;23(12):2085-2088
    Singapore experienced its first documented Zika virus outbreak in 2016. We identified clinical and laboratory parameters that increase the probability for Zika or dengue virus infection. Early during the illness, combinations of key parameters obtained through clinical assessment and hematologic tests can help distinguish between these infections. Read More

    Pharmacophoric characteristics of dengue virus NS2B/NS3pro inhibitors: a systematic review of the most promising compounds.
    Arch Virol 2017 Nov 16. Epub 2017 Nov 16.
    Laboratório de Microbiologia Médica, Campus Centro-Oeste Dona Lindu, Universidade Federal de São João Del Rei (UFSJ), Rua Sebastião Gonçalves Coelho, 400, Divinópolis, Minas Gerais, CEP 35501-293, Brazil.
    Dengue virus (DENV) infection can lead to a wide range of clinical manifestations, including fatal hemorrhagic complications. There is a need to find effective pharmacotherapies to treat this disease due to the lack of specific immunotherapies and antiviral drugs. That said, the DENV NS2B/NS3pro protease complex is essential in both the viral multiplication cycle and in disease pathogenesis, and is considered a promising target for new antiviral therapies. Read More

    [Dengue fever : Symptoms, epidemiology, entomology, pathogen diagnosis and prevention].
    Hautarzt 2017 Nov 16. Epub 2017 Nov 16.
    Fachbereich Tropenmedizin am Bernhard-Nocht Institut, Bundeswehrkrankenhaus Hamburg, Bernhard-Nocht Str. 74, 20359, Hamburg, Deutschland.
    Dengue infections are among the most frequent causes of febrile disease in tropical climates. Infections are caused by a flavivirus transmitted by the Aedes mosquito. Aedes aegypti mosquitos are the main transmitters of Dengue viruses. Read More

    Development and physiological effects of an artificial diet for Wolbachia-infected Aedes aegypti.
    Sci Rep 2017 Nov 16;7(1):15687. Epub 2017 Nov 16.
    Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou - Fiocruz, Belo Horizonte, MG, 30190-002, Brazil.
    The endosymbiotic bacterium Wolbachia spreads rapidly through populations of Aedes aegypti mosquitoes, and strongly inhibits infection with key human pathogens including the dengue and Zika viruses. Mosquito control programs aimed at limiting transmission of these viruses are ongoing in multiple countries, yet there is a dearth of mass rearing infrastructure specific to Wolbachia-infected mosquitoes. One example is the lack of a blood meal substitute, which accounts for the Wolbachia-specific physiological changes in infected mosquitoes, that allows the bacterium to spread, and block viral infections. Read More

    RNAi screen reveals a role of SPHK2 in dengue virus-mediated apoptosis in hepatic cell lines.
    PLoS One 2017 16;12(11):e0188121. Epub 2017 Nov 16.
    Division of Molecular Medicine, Department of Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
    Hepatic dysfunction is a feature of dengue virus (DENV) infection. Hepatic biopsy specimens obtained from fatal cases of DENV infection show apoptosis, which relates to the pathogenesis of DENV infection. However, how DENV induced liver injury is not fully understood. Read More

    Behavioral, climatic, and environmental risk factors for Zika and Chikungunya virus infections in Rio de Janeiro, Brazil, 2015-16.
    PLoS One 2017 16;12(11):e0188002. Epub 2017 Nov 16.
    David Geffen UCLA School of Medicine, Los Angeles, California, United States of America.
    The burden of arboviruses in the Americas is high and may result in long-term sequelae with infants disabled by Zika virus infection (ZIKV) and arthritis caused by infection with Chikungunya virus (CHIKV). We aimed to identify environmental drivers of arbovirus epidemics to predict where the next epidemics will occur and prioritize municipalities for vector control and eventual vaccination. We screened sera and urine samples (n = 10,459) from residents of 48 municipalities in the state of Rio de Janeiro for CHIKV, dengue virus (DENV), and ZIKV by molecular PCR diagnostics. Read More

    Host target-based approaches against arboviral diseases.
    Biol Chem 2017 Nov 27. Epub 2017 Nov 27.
    In the 20th century, socioeconomic and environmental changes facilitated the reintroduction of mosquitoes in developing cities, resulting in the reintroduction of mosquito-borne viral diseases and the dispersal of their causative agents in a worldwide scale. Recurrent outbreaks of arboviral diseases are being reported, even in regions without a previous history of arboviral disease transmission. Of note, arboviral infections represented approximately 30% of all emerging vector-borne diseases of the last decade. Read More

    Clinical Audit of Dengue Related Deaths in 2011-Mayo Hospital Lahore Pakistan.
    Pak J Med Sci 2017 Sep-Oct;33(5):1070-1073
    Sajid Abaidullah, FCPS. Department of Medicine, Mayo Hospital, Lahore, Pakistan.
    Background And Objective: Dengue infection has evolved into an epidemic during last few years in Pakistan and has been associated with poor outcomes. Literature with respect to mortality risk factors in Dengue infection is not sufficient. This compelled us to conduct this study to find out major contributory factors to death in patients with dengue viral infection at one of Asia's ancient hospital setting with an aim to recognize complications at earliest and improve case management in future. Read More

    Multiplexed biomarker panels discriminate Zika and Dengue virus infection in humans.
    Mol Cell Proteomics 2017 Nov 15. Epub 2017 Nov 15.
    Dept of Pharmacology & HiT Center, Johns Hopkins Medical Institute, United States of America
    Zika virus (ZIKV) and dengue virus (DENV) are closely related flaviviruses that cause widespread, acute febrile illnesses, notably microcephaly for fetuses of infected pregnant women. Detecting the viral cause of these illnesses is paramount to determine risks to patients, counsel pregnant women, and help fight outbreaks. A combined diagnostic algorithm for ZIKV and DENV requires Reverse transcription polymerase chain reaction (RT-PCR) and IgM antibody detection. Read More

    Molecular Detection and Characterization of Wolbachia pipientis from Culex quinquefasciatus Collected from Lahore, Pakistan.
    Am J Trop Med Hyg 2017 Oct 23. Epub 2017 Oct 23.
    Department of Zoology, GC University, Lahore, Pakistan.
    The gram-negative, pleomorphic endosymbiont Wolbachia is known to infect a large number of insects and other arthropods naturally. This bacterium modifies the host biology, mainly causing reproductive alterations including feminization, death of male, parthenogenesis, and importantly cytoplasmic incompatibility. Wolbachia-induced cytoplasmic incompatibility results in nonviable offspring and vector population suppression. Read More

    Monitoring and Control of Aedes albopictus, a Vector of Zika Virus, Near Residences of Imported Zika Virus Patients during 2016 in South Korea.
    Am J Trop Med Hyg 2017 Nov 13. Epub 2017 Nov 13.
    Korea Center for Disease Control and Prevention, Osong, Chungbuk, Republic of Korea.
    Zika virus (ZIKV) is an arthropod-borne virus mainly transmitted by Aedes species. A total of nine of the 16 imported ZIKV reported cases during the mosquito season in the Republic of Korea (ROK), following the return of local nationals from foreign ZIKV endemic countries, were surveyed for Aedes albopictus. Surveillance and vector control of Ae. Read More

    Dengue Fever Surveillance in India Using Text Mining in Public Media.
    Am J Trop Med Hyg 2017 Oct 23. Epub 2017 Oct 23.
    Department of Computer Science, North Carolina State University, Raleigh, North Carolina.
    Despite the improvement in health conditions across the world, communicable diseases remain among the leading mortality causes in many countries. Combating communicable diseases depends on surveillance, preventive measures, outbreak investigation, and the establishment of control mechanisms. Delays in obtaining country-level data of confirmed communicable disease cases, such as dengue fever, are prompting new efforts for short- to medium-term data. Read More

    Resource Use and Costs of Dengue: Analysis of Data from Phase III Efficacy Studies of a Tetravalent Dengue Vaccine.
    Am J Trop Med Hyg 2017 Oct 16. Epub 2017 Oct 16.
    Dengue Vaccination Impact and Economics, Sanofi Pasteur, Lyon, France.
    A tetravalent dengue vaccine (CYD-TDV) has recently been approved in 12 countries in southeast Asia and Latin America for individuals aged 9-45 years or 9-60 years (age indication approvals vary by country) living in endemic areas. Data on utilization of medical and nonmedical resources as well as time lost from school and work were collected during the active phase of two phase III efficacy studies performed in 10 countries in the Asia-Pacific region and Latin America (NCT01373281; NCT01374516). We compared dengue-related resource utilization and costs among vaccinated and nonvaccinated participants. Read More

    [Epidemiology of imported infectious diseases in China, 2013-2016].
    Zhonghua Liu Xing Bing Xue Za Zhi 2017 Nov;38(11):1499-1503
    Public Health Emergency Center, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
    Objective: To describe the epidemic of imported infectious diseases in China between 2013 and 2016, including the kinds of infectious diseases, affected provinces, source countries and the epidemiological characteristics, and provide scientific information for the prevention and control of imported infectious diseases. Methods: Data of cases of imported infectious diseases in China from 2013 to 2016 were collected from national information reporting system of infectious diseases, Microsoft Excel 2010 and SPSS 18.0 were used to conduct data cleaning and analysis. Read More

    Multiple effects of toxins isolated from Crotalus durissus terrificus on the hepatitis C virus life cycle.
    PLoS One 2017 15;12(11):e0187857. Epub 2017 Nov 15.
    Genomics Study Laboratory, São Paulo State University, IBILCE, S. José do Rio Preto, São Paulo, Brazil.
    Hepatitis C virus (HCV) is one of the main causes of liver disease and transplantation worldwide. Current therapy is expensive, presents additional side effects and viral resistance has been described. Therefore, studies for developing more efficient antivirals against HCV are needed. Read More

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