415 results match your criteria Demodicosis


Review of extralabel use of isoxazolines for treatment of demodicosis in dogs and cats.

J Am Vet Med Assoc 2020 Jun;256(12):1342-1346

Amitraz is presently the only FDA-approved treatment for demodicosis in dogs in the United States. Amitraz treatment involves a protracted course of administration and risks of severe adverse effects such as sedation, bradycardia, and respiratory depression, which are caused by activation of α-adrenergic receptors. Other treatment options include macrocyclic lactones and lime sulfur, but these products have varied efficacy and high risks of adverse effects. Read More

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http://dx.doi.org/10.2460/javma.256.12.1342DOI Listing

Effectiveness of benzyl benzoate treatment on clinical symptoms and Demodex density over time in patients with rosacea and demodicosis: a real life retrospective follow-up study comparing low- and high-dose regimens.

J Dermatolog Treat 2020 May 19:1-28. Epub 2020 May 19.

Université Libre de Bruxelles (ULB), Institut de Recherche Interdisciplinaire en Biologie humaine et moléculaire (IRIBHM) & Service de Biostatistique et Informatique médicale (SBIM), Route de Lennik 808/CP602, 1070 Brussels, Belgium.

Patients with rosacea and demodicosis have high facial skin Demodex densities (Dds), which decrease with benzyl benzoate (BB) treatment. To evaluate the impact of topical BB (+crotamiton) treatment on Dds and clinical symptoms during prolonged follow-up and to compare low (12% once daily) and high (12% twice daily or 20-24% once daily) BB dose regimens. This retrospective study included 344 patients (103 rosacea, 241 demodicosis) observed for 7. Read More

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http://dx.doi.org/10.1080/09546634.2020.1770168DOI Listing

blepharokeratoconjunctivitis affecting young patients: A case series.

Indian J Ophthalmol 2020 May;68(5):745-749

Cornea Department, Dr. Shroff's Charity Eye Hospital, New Delhi, India.

Purpose: To report clinical characteristics of Demodex blepharokeratoconjunctivitis affecting young patients.

Methods: This is a retrospective review of 14 patients with the history of chronic red eyes with corneal involvement. All patients were diagnosed with ocular demodicosis based on the results of eyelash sampling. Read More

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http://dx.doi.org/10.4103/ijo.IJO_1402_19DOI Listing

Demodex: a skin resident in man and his best friend.

J Eur Acad Dermatol Venereol 2020 Apr 15. Epub 2020 Apr 15.

UCD Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.

Demodex mites are microscopic arachnids found in the normal skin of many mammals. In humans, it is well established that Demodex mite density is higher in patients with the skin condition rosacea, and treatment with acaricidal agents is effective in resolving symptoms. However, pathophysiology of rosacea is complex and multifactorial. Read More

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http://dx.doi.org/10.1111/jdv.16461DOI Listing

Poikilocytosis in the acne vulgaris comorbidity with demodicosis and functional gallbladder disorder.

Wiad Lek 2020 ;73(2):289-292

Sumy State University, Sumy, Ukraine.

Objective: The aim of the study was to evaluate the role of poikilocytosis in the acne vulgaris comorbidity with demodicosis and functional gallbladder disorder.

Patients And Methods: Materials and methods: The study included 140 people with a diagnosis of moderate acne: group 1 - patients with AV, group 2 - patients with AV + Demodicosis, group3- AV + Demodicosis + functional gallbladder disorder (FGD). Biochemical analysis of lipid profile and liver enzymes, bilirubin was performed with semi-automatic analyzer HUMALYZER 3000. Read More

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Prevalence and risk factors to infection in eyelash follicles from a university population of Mexico.

Acta Microbiol Immunol Hung 2020 Mar 30:1-5. Epub 2020 Mar 30.

Departamento de Parasitología, Escuela Nacional de Ciencias Biológicas, Instituto Politécnico Nacional,Ciudad de Méxicoy, México.

shows a high occurrence in the general population, however, its pathologic relevance is still controversial. In this prospective study, we evaluated the prevalence of on eyelashes from 8,033 subjects of a university population (including 7,782 students, and 251 academics). Additional information on some risk factors to infection by the mites was evaluated, as well. Read More

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http://dx.doi.org/10.1556/030.2020.01067DOI Listing
March 2020
0.778 Impact Factor

Blepharitis Caused by

Turkiye Parazitol Derg 2020 Mar;44(1):21-24

Çukurova Üniversitesi Tıp Fakültesi, Parazitoloji Anabilim Dalı, Adana, Türkiye

Objective: Demodicosis is a Skin disease in humans caused by and mites. infestation is mostly located in sebaceous and meibomian glands in the hair follicles. The aim of this study was to determine the age and sex distribution of Demodex infestation in patients with blepharitis. Read More

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http://dx.doi.org/10.4274/tpd.galenos.2019.6476DOI Listing

Canine T-zone lymphoma: an apparent risk factor for adult-onset demodicosis.

J Small Anim Pract 2020 May 20;61(5):323-324. Epub 2020 Mar 20.

Department of Medical Oncology, Centre Vétérinaire Rive-Sud, 7415 Taschereau, Brossard, QC, J4Y 1A2, Canada.

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http://dx.doi.org/10.1111/jsap.13128DOI Listing

Canine T-zone lymphoma: an apparent risk factor for adult-onset demodicosis - reply.

J Small Anim Pract 2020 May 12;61(5):325. Epub 2020 Mar 12.

Clinical Sciences and Services, The Royal Veterinary College, Hatfield, Herts AL9 7TA, UK.

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http://dx.doi.org/10.1111/jsap.13126DOI Listing

Canine demodicosis: Hematological and biochemical alterations.

Vet World 2020 Jan 10;13(1):68-72. Epub 2020 Jan 10.

Department of Physiology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt.

Background And Aim: One of the most common cutaneous infections seen in veterinary canine practice is canine demodicosis. Demodicosis is a parasitic skin infection with a possible impact on acute-phase proteins (APPs) and oxidant-antioxidant balance. This study aimed to estimate the possible alterations in hematological, biochemical, oxidant-antioxidant, and APP (C-reactive protein [CRP] and albumin) profiles in naturally infected dogs with demodicosis. Read More

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http://dx.doi.org/10.14202/vetworld.2020.68-72DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7020110PMC
January 2020

Quantification of immuno-regulatory cytokine and toll-like receptors gene expression in dogs with generalized demodicosis.

Vet Parasitol 2020 Apr 25;280:109063. Epub 2020 Feb 25.

Department of Veterinary Pharmacology and Toxicology, College of Veterinary Science and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, 281001 UP, India.

The proliferation of Demodex mites is mainly controlled by host immunity; however, the precised mechanism of host-mite interplay and host immune response in the cutaneous microenvironment of dogs with generalized demodicosis (GD) are not yet established. In the present study, we envisaged the alterations in the expression of toll-like receptors (TLRs) and immuno-regulatory cytokine gene in the skin lesions and peripheral blood mononuclear cells (PBMCs) of dogs with GD. The expression of TLR2, TLR6, IFN-γ, TGF-β and IL-10 genes in the skin lesions and PBMCs of 15 dogs with GD was quantified by qRT-PCR. Read More

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http://dx.doi.org/10.1016/j.vetpar.2020.109063DOI Listing

Demodex folliculorum infestations in common facial dermatoses: acne vulgaris, rosacea, seborrheic dermatitis.

An Bras Dermatol 2020 Mar - Apr;95(2):187-193. Epub 2020 Feb 12.

Department of Dermatology and Venereology, Faculty of Medicine, Bahçeşehir University, Istanbul, Turkey.

Background: Demodex mites are found on the skin of many healthy individuals. Demodex mites in high densities are considered to play a pathogenic role.

Objective: To investigate the association between Demodex infestation and the three most common facial dermatoses: acne vulgaris, rosacea and seborrheic dermatitis. Read More

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http://dx.doi.org/10.1016/j.abd.2019.08.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7175027PMC

Clinical and histological recovery of non-thymoma-associated exfoliative dermatitis in a cat treated with ciclosporin A.

JFMS Open Rep 2020 Jan-Jun;6(1):2055116920902307. Epub 2020 Feb 11.

Department of Clinical Sciences, Université de Toulouse, ENVT, Toulouse, France; UDEAR, Université de Toulouse, INSERM, ENVT, Toulouse, France.

Case Summary: A 6-year-old neutered female European Shorthair cat was referred for chronic, moderately pruritic, alopecic and exfoliative dermatosis that was unresponsive to antiparasitic, antibiotic or steroidal anti-inflammatory drugs. The cat presented with truncular alopecia and numerous whitish adherent scales covering the whole body. Differential diagnoses included sebaceous adenitis, dermatophytosis, demodicosis, exfoliative dermatitis associated or not with thymoma, drug reaction, feline immunodeficiency virus- or feline leukaemia virus-associated dermatoses, epitheliotropic T-cell lymphoma, and yeasts and/or bacterial overgrowth. Read More

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http://dx.doi.org/10.1177/2055116920902307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7013115PMC
February 2020

Pyoderma faciale as a possible form of demodicosis in a subset of patients? New insights from dermoscopic examination.

G Ital Dermatol Venereol 2020 Feb 10. Epub 2020 Feb 10.

Department of Experimental and Clinical Medicine, Institute of Dermatology, University of Udine, Udine, Italy.

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http://dx.doi.org/10.23736/S0392-0488.19.06452-6DOI Listing
February 2020

Oral fluralaner as a treatment for and in a golden (Syrian) hamster .

Can Vet J 2020 Feb;61(2):135-137

Dermatology Service, Groupe D.M.V, Montréal, Québec H8T 3R2.

A 16-month-old male hamster was diagnosed with generalized demodicosis with both and and was treated successfully with oral fluralaner at a dose of 25 mg/kg body weight that was repeated on day 60. After the first dose, there was a rapid improvement of the skin lesions, and negative skin scrapings were obtained on day 30. To the author's knowledge, this is the first published report of the use of an isoxazoline to treat demodicosis in a hamster. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6973213PMC
February 2020

Diagnosis and treatment of demodicosis in dogs and cats: Clinical consensus guidelines of the World Association for Veterinary Dermatology.

Vet Dermatol 2020 Feb;31(1):5-27

Dermatology for Animals, 263 Appleby Road, Stafford Heights, Brisbane, Queensland, 4053, Australia.

Background: Demodicosis is a common disease in small animal veterinary practice worldwide with a variety of diagnostic and therapeutic options.

Objectives: To provide consensus recommendations on the diagnosis, prevention and treatment of demodicosis in dogs and cats.

Methods And Materials: The authors served as a Guideline Panel (GP) and reviewed the literature available before December 2018. Read More

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http://dx.doi.org/10.1111/vde.12806DOI Listing
February 2020

Nodular Demodicosis in a Pregnant Woman Treated with Oral Ivermectin and Metronidazole.

Skinmed 2019 1;17(5):334-336. Epub 2019 Sep 1.

Dermatology of the Central States, Bexley, OH.

A 32-year-old woman presented at 12 weeks' gestation with a severe nodulopustular reaction involving the central region of the forehead and the right cheek (Figures 1 and 2). This had progressively worsened over a several-week period despite use of topical metronidazole. A preparation revealed numerous mites from each pustule that was sampled. Read More

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Crusted demodicosis in an immunocompetent patient.

Cutis 2019 Oct;104(4):E9-E11

Department of Dermatology, University of Florida, Gainesville, USA.

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October 2019

Superglue slide impression (SSI) method: a novel diagnostic application for canine demodicosis.

Authors:
Shanker K Singh

Exp Appl Acarol 2019 Dec 25;79(3-4):387-393. Epub 2019 Nov 25.

Department of Veterinary Medicine, College of Veterinary Science and Animal Husbandry, U.P. Pandit Deen Dayal Upadhyaya Pashu-Chikitsa Vigyan Vishwavidyalaya Evam Go Anusandhan Sansthan (DUVASU), Mathura, U.P., 281 001, India.

The conventional gold standard diagnostic method for canine demodicosis, the deep skin scrapings (DSS), is traumatic to the animal and appears aggressive in the eyes of the owner. A less invasive, sensitive, easy-to-perform and field-oriented diagnostic method for the rapid diagnosis of canine demodicosis is warranted. The present study aimed to develop a rapid less invasive diagnostic method using superglue (cyanoacrylate adhesive) slide impression (SSI). Read More

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http://dx.doi.org/10.1007/s10493-019-00444-7DOI Listing
December 2019

STAT1 gain-of-function and chronic demodicosis.

Pediatr Dermatol 2020 Jan 21;37(1):153-155. Epub 2019 Oct 21.

Department of Dermatology, Hadassah Medical Center, The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Heterozygous STAT1 gain-of-function (GOF) mutations result in a combined form of immunodeficiency which is the most common genetic cause of chronic mucocutaneous candidiasis (CMC). We present a pedigree with a GOF mutation in STAT1, manifesting with chronic demodicosis in the form of a facial papulopustular eruption, blepharitis, and chalazion. So far, demodicosis has been described in only one family with STAT1-GOF mutation. Read More

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http://dx.doi.org/10.1111/pde.14011DOI Listing
January 2020
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Juvenile-onset and adult-onset demodicosis in dogs in the UK: prevalence and breed associations.

J Small Anim Pract 2020 Jan 4;61(1):32-41. Epub 2019 Oct 4.

Clinical Sciences and Services, The Royal Veterinary College, Hatfield, Herts, AL9 7TA, UK.

Objectives: To explore epidemiological features of demodicosis relevant to UK veterinary general practitioners. Breed risk factors were proposed as distinct between juvenile-onset and adult-onset disease.

Materials And Methods: The study used anonymised clinical data on dogs under primary veterinary care at practices enrolled in the UK VetCompass Programme. Read More

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http://dx.doi.org/10.1111/jsap.13067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7003809PMC
January 2020
1 Read

Treatment of Demodex-associated inflammatory skin conditions: A systematic review.

Dermatol Ther 2019 11 28;32(6):e13103. Epub 2019 Oct 28.

Pharmacy Service, Durham Veterans Affairs Health Care System, Durham, North Carolina.

Bacterial folliculitis, rosacea, and other common skin conditions have been linked to infestation by Demodex mites (human demodicosis). Currently, there is little guidance for treatment of inflammatory conditions associated with demodicosis. Thus, the objective of this review is to evaluate the efficacy and safety of treatments utilized for Demodex infestation. Read More

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http://dx.doi.org/10.1111/dth.13103DOI Listing
November 2019
2 Reads

Palpebral and facial skin infestation by Demodex folliculorum.

Cont Lens Anterior Eye 2020 Apr 25;43(2):115-122. Epub 2019 Sep 25.

École d'optométrie, Université de Montréal, 3744 Rue Jean-Brillant, H3T 1P1, Montréal, Québec, Canada. Electronic address:

Purpose: To evaluate facial Demodex densities in participants with varying severities of blepharitis secondary to Demodex folliculorum assessed by the highest number of cylindrical dandruff on one lid.

Methods: This double masked cross-sectional study included 58 participants [19 control, 21 mild/moderate and 18 severe Demodex blepharitis] who underwent a standardized skin-surface biopsy and a lash epilation for each lid to obtain the forehead Demodex densities and the overall lash mite count, respectively. Also, facial photographs were taken to evaluate facial erythema and dermatological conditions. Read More

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http://dx.doi.org/10.1016/j.clae.2019.09.001DOI Listing
April 2020
1 Read

Immune mechanisms in human and canine demodicosis: A review.

Parasite Immunol 2019 12 8;41(12):e12673. Epub 2019 Oct 8.

Parasitology Unit, Department of Microbiology and Molecular Genetics, The Kuvin Center for the Study of Infectious and Tropical Diseases, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

Demodex mites are saprophytic parasites of the mammalian skin, mostly found in or near pilosebaceous units of hairy regions. While they can be found in healthy humans and animals without causing any clinical manifestations, they were suggested to create pathogenic symptoms when they appear in high densities under favourable conditions (ie, demodicosis). Nevertheless, their role as the primary causative agent of the pathogenic conditions in humans is debated today. Read More

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http://dx.doi.org/10.1111/pim.12673DOI Listing
December 2019
2 Reads

Increased frequency of Demodex blepharitis in rosacea and facial demodicosis patients.

J Cosmet Dermatol 2020 May 25;19(5):1260-1265. Epub 2019 Sep 25.

Department of Dermatology, Liv Hospital Ulus, Istanbul, Turkey.

Background: Rosacea is an inflammatory disease with 50% of ocular involvement rate. Primary demodicosis is an eruption caused by Demodex mites, and there is no data about the rate of ocular involvement in primary demodicosis.

Aims: In this cross-sectional study, it is aimed to reveal the frequency of Demodex blepharitis in rosacea and primary demodicosis patients. Read More

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http://dx.doi.org/10.1111/jocd.13150DOI Listing
May 2020
1 Read

Treatment of rosacea and demodicosis with benzyl benzoate: effects of different doses on Demodex density and clinical symptoms.

J Eur Acad Dermatol Venereol 2020 Feb 17;34(2):365-369. Epub 2019 Oct 17.

Institut de Recherche Interdisciplinaire en Biologie humaine et moléculaire (IRIBHM) & Service de Biostatistique et Informatique médicale (SBIM), Université Libre de Bruxelles (ULB), Brussels, Belgium.

Background: Patients with rosacea or demodicosis have high facial skin Demodex densities (Dds). Topical ivermectin, benzyl benzoate (BB) and crotamiton have been shown to decrease Dds in vivo, but there are few data on the clinical and acaricidal effects of BB among patients with rosacea.

Objective: To evaluate the impact of topical BB (+crotamiton) treatment on Dds and clinical symptoms of rosacea and demodicosis, and compare three BB treatment regimens. Read More

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http://dx.doi.org/10.1111/jdv.15938DOI Listing
February 2020
1 Read

Is there a correlation between canine adult-onset demodicosis and other diseases?

Vet Rec 2019 12 13;185(23):729. Epub 2019 Aug 13.

Centre for Clinical Veterinary Medicine, University of Munich, Munich, Germany

Demodicosis is frequently seen in small animal practice. In older dogs, it is often associated with immunosuppression and immunosuppressive diseases. The aim of this study was to evaluate a larger number of dogs with adult-onset demodicosis (AOD) at the veterinary teaching hospitals of the University of Sydney/Australia and the University of Munich/Germany. Read More

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http://dx.doi.org/10.1136/vr.105388DOI Listing
December 2019
4 Reads

Demodicosis revealing an HIV infection.

New Microbes New Infect 2019 Sep 9;31:100525. Epub 2019 Jun 9.

Service des maladies infectieuses, CHU Farhat Hached, Sousse, Tunisia.

We report an observation of facial and upper limb demodicosis, revealing a human immunodeficiency virus infection. After an initial improvement with metronidazole, worsening of skin lesions related to immune reconstitution inflammatory syndrome was observed, requiring the use of steroids. Read More

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http://dx.doi.org/10.1016/j.nmni.2019.100525DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6676229PMC
September 2019
1 Read

A new superficial needle-scraping method for assessing Demodex density in papulopustular rosacea.

J Cosmet Dermatol 2020 Apr 25;19(4):896-900. Epub 2019 Jul 25.

Department of Dermatology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Standardized skin surface biopsy (SSSB) is often performed to determine the density of Demodex mites in facial papulopustular eruptions.

Aim: We aimed to test the applicability of a new, "superficial needle-scraping" (SNS) method for assessing Demodex density in papulopustular rosacea (PPR).

Patients And Methods: Using SNS method, we measured the Demodex density in patients with PPR, also enrolling the patients with acne vulgaris as controls. Read More

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http://dx.doi.org/10.1111/jocd.13082DOI Listing
April 2020
7 Reads

Demodicosis in a captive African straw-coloured fruit bat (Eidolon helvum).

Exp Appl Acarol 2019 Aug 9;78(4):547-554. Epub 2019 Jul 9.

Pathology Department, Animal and Plant Health Agency (APHA-Weybridge), Woodham Lane, Addlestone, Surrey, KT15 3NB, UK.

Demodicosis is most frequently observed in the domestic dog (Canis familiaris), but it has rarely been reported in bats (Chiroptera). The overpopulation of Demodex spp. that causes dermatological changes is generally associated with a compromised immune system. Read More

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http://dx.doi.org/10.1007/s10493-019-00399-9DOI Listing
August 2019
2 Reads

CUTANEOUS DEMODICOSIS AND UV-INDUCED SKIN NEOPLASIA IN TWO GOELDI'S MONKEYS ().

J Zoo Wildl Med 2019 Jun 13;50(2):470-473. Epub 2019 Jun 13.

German Primate Center, Leibniz Institute for Primate Research, Pathology Unit, Kellnerweg 4, 37077 Göttingen, Germany.

Two nonrelated Goeldi's monkeys () from the same enclosure developed multifocal alopecia with hyperkeratotic to ulcerative skin lesions on the lower abdomen and inner thighs. Necropsy samples of the first animal showed hyperplastic dermatitis together with in situ carcinoma and intralesional organisms. The second monkey developed similar lesions 2. Read More

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http://dx.doi.org/10.1638/2017-0206DOI Listing
June 2019
6 Reads

[PATHOGENETIC FEATURES AND METHODS FOR TREATMENT OF VARIOUS FORMS OF ROSACEA].

Georgian Med News 2019 Apr(289):116-120

Tbilisi State Medical University, Department of Dermatology and Venerology, Georgia.

The aim of the work was to study the features of the pathogenesis of various clinical forms of rosacea (the presence of mite Demodex folliculorum, the determination of VEGF, IL-2 IL-6, IL-8) and, based on the obtained results, to ensure adequate methods of therapy. Mite identification was performed by microscopy. The concentration of cytokines in patients with various clinical forms of rosacea (papulopustular form 15 patients, steroid form - 15, erythematous telangiectic form - 10, Ophthalmo Rosacea - 3, rhinophyma - 3) was determined by enzyme immunoassay using appropriate monoclonal antibodies and expressed in samples. Read More

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April 2019
9 Reads

Definition of videodermoscopic features of demodicosis.

Int J Dermatol 2019 Oct 14;58(10):1153-1159. Epub 2019 Jun 14.

Department of Dermatology and Venereology, Erciyes University Faculty of Medicine, Kayseri, Turkey.

Background: Diagnosis of demodicosis is usually confirmed by standardized skin surface biopsy. The skin of the patients with demodicosis is usually very sensitive. There is a need for new noninvasive tests. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/ijd.14547
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http://dx.doi.org/10.1111/ijd.14547DOI Listing
October 2019
5 Reads

A case series of demodicosis in children.

Pediatr Dermatol 2019 Sep 13;36(5):651-654. Epub 2019 Jun 13.

Pennsylvania State College of Medicine, Hershey, Pennsylvania.

Demodex mites are commensal inhabitants of the pilosebaceous unit that are typically absent or at low numbers in childhood. When they are present, they can cause a primary eruption or exacerbate an underlying facial dermatosis. Here we report five cases of demodicosis occurring in childhood, the clinical presentations, and responses to treatment. Read More

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http://dx.doi.org/10.1111/pde.13852DOI Listing
September 2019
6 Reads

Unilateral palpebral oedema secondary to granulomatous demodicosis.

Arch Soc Esp Oftalmol 2019 Oct 10;94(10):e74. Epub 2019 Jun 10.

Unidad de Dermatología, Hospital de Barbastro, Barbastro, Huesca, España. Electronic address:

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http://dx.doi.org/10.1016/j.oftal.2019.05.003DOI Listing
October 2019
2 Reads

Comparison of acetate tape impression, deep skin scraping, and microscopic examination of hair for therapeutic monitoring of dogs with juvenile generalized demodicosis: A pilot study.

Can Vet J 2019 06;60(6):596-600

Consultorio de Especialidades en Dermatología y Alergología en Perros y Gatos, Parroquia 329, Colonia del Valle Sur, 03100, Ciudad de México, México (Barillas); Veterinary Dermatology & Ear Referral Medical Clinic, Burnaby, British Columbia (Bajwa); Department of Parasitology, Mycology and Dermatology, Dynamic Research Group, École Nationale Vétérinaire d'Alfort, UPE, 94704, Maisons-Alfort, France (Guillot); Specialty in Medicine and Surgery in Small Species, School of Veterinary Medicine of the DelaSalle Bajío University, Av. Universidad 602 Col. Lomas del Campestre, C.P. 37150, León, Gto, Mexico (Arcique).

The standard method for diagnosis and therapeutic monitoring of dogs with demodicosis is microscopic examination of deep skin scrapings. Previous studies have compared deep skin scraping and microscopic hair examination to acetate tape impression with skin squeezing for the diagnosis of demodicosis but the latter has never been evaluated for therapeutic monitoring. The main purpose of this study was to evaluate acetate tape impression with skin squeezing as a therapeutic monitoring tool for dogs with juvenile onset generalized demodicosis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6515801PMC
June 2019
3 Reads

Ocular demodicosis: A review.

Arch Soc Esp Oftalmol 2019 Jul 29;94(7):316-322. Epub 2019 May 29.

Laboratorio de Microbiología Molecular, Escuela de Tecnología Médica, Universidad Austral de Chile, Puerto Montt, Chile. Electronic address:

Demodex folliculorum and Demodex brevis are ectoparasites that inhabit the skin of humans. They have been related to alterations in the ocular surface, such as, dysfunction of Meibomian glands, blepharitis, chalazion, etc. Ocular demodicosis is characterised by the pathognomonic presence of cylindrical dandruff at the base of the eyelashes, and various symptoms including, among others, itching, lacrimation, and hyperaemia. Read More

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http://dx.doi.org/10.1016/j.oftal.2019.04.003DOI Listing
July 2019
14 Reads

Efficacy of oral fluralaner for the treatment of canine generalized demodicosis: a molecular-level confirmation.

Parasit Vectors 2019 May 28;12(1):270. Epub 2019 May 28.

Department of Biology, Faculty of Veterinary Medicine, University of Belgrade, Bul. oslobodjenja 18, 11000, Belgrade, Serbia.

Background: Canine generalized demodicosis is a common parasitic disease caused by the proliferation of Demodex mites. The introduction of isoxazoline class treatments in veterinary dermatology has resulted in apparently effective treatment of generalized demodicosis. The objective of this study was to evaluate the effectiveness of fluralaner for the treatment of canine generalized demodicosis using real-time PCR for the detection and quantification of Demodex DNA. Read More

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https://parasitesandvectors.biomedcentral.com/articles/10.11
Publisher Site
http://dx.doi.org/10.1186/s13071-019-3521-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6537169PMC
May 2019
12 Reads

Skin-homing T-cell responses associated with Demodex infestation and rosacea.

Parasite Immunol 2019 08 17;41(8):e12658. Epub 2019 Jun 17.

Department of Medical Microbiology and Clinical Microbiology, Faculty of Medicine, Near East University, Nicosia, Northern Cyprus.

Aims: Our aim was to investigate the skin-homing T-cell immune responses triggered in patients with Demodex infestation and/or rosacea.

Methods: Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patients without Demodex infestation (Rosacea group); and PPR patients with Demodex infestation (Rosacea/Demodex group). Following ex vivo activation, skin-homing CLA+CD4+ T-cell subset levels were monitored by flow cytometry. Read More

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http://dx.doi.org/10.1111/pim.12658DOI Listing
August 2019
11 Reads

A comparison of the efficacy and tolerability of topical agents used in facial Demodex treatment.

Authors:
Gulbahar Sarac

J Cosmet Dermatol 2019 Dec 8;18(6):1784-1787. Epub 2019 May 8.

Department of Dermatology, Inonu University School of Medicine, Malatya, Turkey.

Background: Demodex spp. is the most common ectoparasite in humans. This parasite is believed to play a role in the etiology of many dermatological and ocular disorders. Read More

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http://dx.doi.org/10.1111/jocd.12986DOI Listing
December 2019
5 Reads

Bilateral demodicosis of the nipple-areola complex.

J Dtsch Dermatol Ges 2019 Jul 23;17(7):733-734. Epub 2019 Apr 23.

Department of Dermatology, University Medical Center Schleswig-Holstein, Campus Kiel, Germany.

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http://dx.doi.org/10.1111/ddg.13844DOI Listing
July 2019
3 Reads

Evaluation of Demodex mite viability using motility and scattered light intensity.

Exp Appl Acarol 2019 Apr 19;77(4):463-469. Epub 2019 Apr 19.

Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.

Demodex mites have been suggested to have a role in various cutaneous and ocular disorders pathogenesis, such as rosacea or blepharitis. Evaluation of potential treatments with anti-Demodex effects is difficult because the viability of living mites needs to be evaluated during their exposure to the agent being tested. Mite viability is currently based solely on their observed movement. Read More

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http://dx.doi.org/10.1007/s10493-019-00358-4DOI Listing
April 2019
8 Reads

Tectonic keratoplasty using femtosecond laser lenticule in pediatric patients with corneal perforation secondary to blepharokeratoconjunctivitis: a case report and literature review.

J Int Med Res 2019 May 11;47(5):2312-2320. Epub 2019 Apr 11.

1 Department of Ophthalmology, the First Hospital of Jilin University, Changchun, Jilin Province, China.

Blepharokeratoconjunctivitis secondary to ocular demodicosis in the pediatric population is often neglected and may result in a serious sight-threatening condition. In severe cases, it can lead to corneal perforation necessitating urgent corneal transplantation. However, the shortage and high cost of donor corneas is the foremost limitation of keratoplasty in developing countries. Read More

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http://dx.doi.org/10.1177/0300060519841163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6567768PMC
May 2019
13 Reads
1.095 Impact Factor

Prospective Study of the Diagnostic Accuracy of the In Vivo Laser Scanning Confocal Microscopy for Ocular Demodicosis.

Am J Ophthalmol 2019 07 6;203:46-52. Epub 2019 Mar 6.

Zhongnan Hospital of Wuhan University, Hubei, China.

Purpose: We sought to determine the diagnostic accuracy of in vivo confocal microscopy (IVCM) for ocular demodicosis.

Design: Reliability and validity analysis.

Methods: This was a single-center study of consecutive patients presenting to Zhongnan Hospital of Wuhan University, Hubei, China, between February 2017 and February 2018 with blepharitis. Read More

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http://dx.doi.org/10.1016/j.ajo.2019.02.026DOI Listing
July 2019
3 Reads

Evaluation of the ocular surface characteristics and Demodex infestation in paediatric and adult blepharokeratoconjunctivitis.

BMC Ophthalmol 2019 Mar 7;19(1):67. Epub 2019 Mar 7.

Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai, 200031, China.

Background: To evaluate the ocular surface characteristics and the infestation of Demodex in Chinese paediatric and adult blepharokeratoconjunctivitis (BKC).

Methods: Fifty consecutive patients with BKC and 50 age- and sex-matched healthy subjects were enrolled. Lid margin characteristics and corneal disorders were evaluated under slit-lamp illumination. Read More

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http://dx.doi.org/10.1186/s12886-019-1074-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407278PMC
March 2019
11 Reads

Erythematotelangiectatic rosacea may be associated with a subclinical stage of demodicosis: a case-control study.

Br J Dermatol 2019 10 29;181(4):818-825. Epub 2019 Mar 29.

Free University of Brussels (ULB), Institut de Recherche Interdisciplinaire en Biologie Humaine et Moléculaire (IRIBHM) and Service de Biostatistique et Informatique Médicale (SBIM), Route de Lennik 808/CP602, 1070, Brussels, Belgium.

Background: Facial densities of Demodex mites have been observed to be greater in patients with demodicosis and papulopustular rosacea than in healthy control patients. In patients with erythematotelangiectatic rosacea (ETR), this density has been observed to be similar to or greater than that of healthy controls. Erythema and telangiectasia, characteristics of ETR, are often observed among patients with pityriasis folliculorum, a discreet demodicosis, suggesting a possible link between these conditions. Read More

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http://dx.doi.org/10.1111/bjd.17817DOI Listing
October 2019
12 Reads

Efficacy of topically administered fluralaner or imidacloprid/moxidectin on dogs with generalised demodicosis.

Parasit Vectors 2019 Jan 25;12(1):59. Epub 2019 Jan 25.

MSD Animal Health Innovation GmbH, GmbH, Zur Propstei, 55270, Schwabenheim, Germany.

Background: Canine demodicosis is classified as localised or generalised according to the extent of the disease. Chronic generalised demodicosis is a difficult skin disease to treat and unlikely to resolve without therapy. This laboratory study compared the efficacy of two topical spot-on medications, fluralaner or a combination of imidacloprid and moxidectin, against naturally acquired generalised demodicosis in dogs. Read More

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http://dx.doi.org/10.1186/s13071-018-3230-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346496PMC
January 2019
4 Reads

Molecular Characterization of Chitin Synthase Gene of Demodex canis from Mizoram, India.

Acta Parasitol 2019 Mar 15;64(1):57-62. Epub 2019 Jan 15.

Department of Veterinary Parasitology, College of Veterinary Sciences and Animal Husbandry, R.K. Nagar, Agartala, Tripura, India.

Aims: Canine demodicosis is a parasitic condition affecting the skin of dogs. The present study was designed to characterize chitin synthase gene of Demodex canis. The molecular technique was used for better understanding of this gene. Read More

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http://dx.doi.org/10.2478/s11686-018-00008-6DOI Listing
March 2019
6 Reads

Critically appraised topic for the most effective and safe treatment for canine generalised demodicosis.

BMC Vet Res 2019 Jan 7;15(1):17. Epub 2019 Jan 7.

Department of Veterinary Medicine (DIMEVET), University of Milan, Via G. Celoria 10, 20133, Milan, Italy.

Background: Canine generalised demodicosis is an inflammatory parasitic skin disease caused by an excessive proliferation of Demodex spp. Generalized demodicosis is a severe skin disease, that can be life threatening if not treated properly. Many of the current treatment options are not licensed for the treatment of generalised demodicosis, it have a low safety margin and may be poorly efficacious and time-consuming for the owner; there is a need for a safe, efficacious treatment for canine demodicosis. Read More

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https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-
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http://dx.doi.org/10.1186/s12917-018-1767-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323682PMC
January 2019
10 Reads

The Importance of Demodex Mites (Acari: Demodicidae) in Patients With Sickle Cell Anemia.

J Med Entomol 2019 04;56(3):599-602

Department of Microbiology and Molecular Genetics, The Kuvin Center for the Study of Infectious and Tropical Diseases, Hadassah Medical School, Hebrew University Jerusalem, Israel.

Although demodicosis caused by Demodex folliculorum and Demodex brevis is widely seen throughout the world, the pathogenic mechanisms are not fully known. To the best of our knowledge, the effect of Demodex mites in patients with sickle cell anemia (SCA) is not known. SCA is a genetic disease characterized by abnormal hemoglobin production and suppression of the immune system. Read More

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https://academic.oup.com/jme/advance-article/doi/10.1093/jme
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http://dx.doi.org/10.1093/jme/tjy225DOI Listing
April 2019
43 Reads