2,026 results match your criteria Dementia and geriatric cognitive disorders[Journal]


Amyloid β42 and Total Tau Levels in Cerebrospinal Fluid Associate with Survival in an 85-Year-Old Population-Based Cohort Followed until Death.

Dement Geriatr Cogn Disord 2019 Apr 10;47(1-2):114-123. Epub 2019 Apr 10.

Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.

Background: Dementia of Alzheimer's type (AD) is related to decreased survival. It is not clear whether also biological markers of AD are related to mortality. Low levels of amyloid beta-42 (Aβ42) and high levels of total tau (T-tau) protein in cerebrospinal fluid (CSF) are established biomarkers for AD. Read More

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http://dx.doi.org/10.1159/000499066DOI Listing
April 2019
1 Read

Factors Associated with the Prevalence of Cognitive Impairment in a Rural Elderly Cameroonian Population: A Community-Based Study in Sub-Saharan Africa.

Dement Geriatr Cogn Disord 2019 Apr 9;47(1-2):104-113. Epub 2019 Apr 9.

Faculty of Health Sciences, University of Buea, Buea, Cameroon.

Background/aims: With rising elderly populations, age-related health problems such as cognitive impairment and dementia are major public health concerns. We sought to assess the prevalence of cognitive impairment and associated factors in rural elderly Cameroonians.

Methods: The Mini Mental State Examination was used to assess the cognitive function of participants randomly recruited during a house-to-house survey of the Batibo Health District. Read More

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http://dx.doi.org/10.1159/000496825DOI Listing

Feasibility of Remote Assessment of Human Prion Diseases for Research and Surveillance.

Dement Geriatr Cogn Disord 2019 Mar 12;47(1-2):79-90. Epub 2019 Mar 12.

Neurology Center Inc., Lorain, Ohio, USA.

Background: Prion disease research and surveillance can be challenging due to the disease's difficulty to diagnose, rapid progression, and geographic dispersion. Improving accessibility through teleneurology could improve the ability to conduct these activities.

Objectives: The aim of this study was to determine the feasibility of conducting teleneurology assessments for research and surveillance of prion diseases. Read More

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http://dx.doi.org/10.1159/000497055DOI Listing
March 2019
1 Read

Distinctive and Pervasive Alterations of Functional Brain Networks in Cerebral Small Vessel Disease with and without Cognitive Impairment.

Dement Geriatr Cogn Disord 2019 Mar 12;47(1-2):55-67. Epub 2019 Mar 12.

Department of Geriatrics, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China,

Objective: To explore the within- and between-network patterns of the default mode network (DMN), the frontoparietal control network (FPCN), and the dorsal attention network (DAN) in cerebral small vessel disease (CSVD) with and without cognitive impairment (CI).

Methods: Twenty CSVD with CI subjects, 21 CSVD without CI subjects, and 25 healthy elderly controls were recruited. The within- and between-network patterns of the networks were identified based on resting-state functional magnetic resonance imaging data. Read More

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https://www.karger.com/Article/FullText/496455
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http://dx.doi.org/10.1159/000496455DOI Listing
March 2019
4 Reads

Prevalence of C9ORF72 Expansion in a Large Series of Patients with Idiopathic Normal-Pressure Hydrocephalus.

Dement Geriatr Cogn Disord 2019 Mar 12;47(1-2):91-103. Epub 2019 Mar 12.

Department of Neurosurgery, Kuopio University Hospital and University of Eastern Finland, Kuopio, Finland.

Background/aims: The C9ORF72 expansion is known to cause frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS). We aim to identify the prevalence of the C9ORF72 expansion in idiopathic normal pressure hydrocephalus (iNPH).

Methods: We analysed the C9ORF72 expansion in a large cohort of patients with possible iNPH (n = 487) and cognitively intact elderly controls (n = 432; age > 65 years). Read More

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https://www.karger.com/Article/FullText/497306
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http://dx.doi.org/10.1159/000497306DOI Listing
March 2019
3 Reads

Vascular Depression and Cognition in Mexican Americans.

Dement Geriatr Cogn Disord 2019 Mar 12;47(1-2):68-78. Epub 2019 Mar 12.

Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA.

Background: Mexican Americans are at increased risk of developing mild cognitive impairment (MCI) and Alzheimer's disease compared to non-Hispanic whites. This study sought to examine the relationship between vascular risk, depression, and cognition in Mexican American elders.

Methods: Data from 470 (390 normal controls, 80 MCI patients) Mexican Americans enrolled in the Health and Aging Brain among Latino Elders (HABLE) study were used. Read More

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https://www.karger.com/Article/FullText/494272
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http://dx.doi.org/10.1159/000494272DOI Listing
March 2019
9 Reads

Predementia Brain Changes in Progranulin Mutation: A Systematic Review of Neuroimaging Evidence.

Dement Geriatr Cogn Disord 2019 Jan 10;47(1-2):1-18. Epub 2019 Jan 10.

School of Graduate Psychology, Pacific University, Hillsboro, Oregon, USA,

Background: Mutations in the progranulin (GRN) gene are a major cause of familial frontotemporal dementia. They result in a loss of progranulin levels and in GRN-related brain degenerative changes that unfold over years if not decades. The aim of our review was to summarize the evidence on emerging functional and structural brain abnormalities in carriers of GRN mutations. Read More

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https://www.karger.com/Article/FullText/494968
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http://dx.doi.org/10.1159/000494968DOI Listing
January 2019
14 Reads

Development of the Central Africa Daily Functioning Interference Scale for Dementia Diagnosis in Older Adults: The EPIDEMCA Study.

Dement Geriatr Cogn Disord 2019 Jan 10;47(1-2):29-41. Epub 2019 Jan 10.

University Limoges, School of Medicine, Institute of Neuroepidemiology and Tropical Neurology, CNRS FR 3503 GEIST, Limoges, France.

Background: There are a few validated tools capable of assessing the dimensions essential for the diagnosis of dementia and cognitive disorders in sub-Saharan Africa.

Objectives: Our aim was to develop an adapted tool, the Central African - Daily Functioning Interference (DFI) scale.

Methods: An initial 16-item scale of activity limitations and participation restrictions was completed by 301 participants with low cognitive performances to assess their level of DFI. Read More

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https://www.karger.com/Article/FullText/492782
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http://dx.doi.org/10.1159/000492782DOI Listing
January 2019
9 Reads

Evaluating Patient Brain and Behavior Pathways to Caregiver Health in Neurodegenerative Diseases.

Dement Geriatr Cogn Disord 2019 Jan 10;47(1-2):42-54. Epub 2019 Jan 10.

Department of Psychology, University of California, Berkeley, Berkeley, California, USA,

Background: Caregivers of patients with neurodegenerative diseases are at heightened risk for serious health problems, but health differences between individual caregivers abound.

Aims: To determine whether atrophy in patient brains could be used to identify caregivers at heightened risk for health problems and which patient variables mediate this relationship.

Methods: In 162 patient-caregiver dyads, we assessed patient atrophy using structural MRI, caregiver health, and patient behavior and cognitive symptoms. Read More

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https://www.karger.com/Article/FullText/495345
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http://dx.doi.org/10.1159/000495345DOI Listing
January 2019
15 Reads

Simultaneous Stimulation of the Globus Pallidus Interna and the Nucleus Basalis of Meynert in the Parkinson-Dementia Syndrome.

Dement Geriatr Cogn Disord 2019 Jan 10;47(1-2):19-28. Epub 2019 Jan 10.

Department of Neurosurgery, Hospital Clínico San Carlos, Health Research Institute of the Hospital Clínico San Carlos, Madrid, Spain.

Background/aim: The prevalence of cognitive symptoms in recently diagnosed Parkinson's disease (PD) patients may be as high as 60%. We report a novel deep brain stimulation (DBS) strategy targeting both motor and cognitive symptoms.

Methods: A PD patient diagnosed with mild cognitive impairment underwent DBS surgery targeting the globus pallidus interna (GPi; to treat motor symptoms) and the nucleus basalis of Meynert (NBM; to treat cognitive symptoms) using a single electrode per hemisphere. Read More

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http://dx.doi.org/10.1159/000493094DOI Listing
January 2019
4 Reads
3.547 Impact Factor

Effects of Light Treatment on Sleep, Cognition, Mood, and Behavior in Alzheimer's Disease: A Systematic Review.

Dement Geriatr Cogn Disord 2018 11;46(5-6):371-384. Epub 2018 Dec 11.

Department of Biomedical and NeuroMotor Sciences, Functional MR Unit, University of Bologna, Bologna, Italy,

Background: Bright light treatment is a therapeutic intervention mainly used to treat sleep and circadian disturbances in Alzheimer's disease (AD) patients. Recently, a handful of studies also focused on the effect on cognition and behavior. Conflicting findings are reported in the literature, and no definite conclusions have been drawn about its specific therapeutic effect. Read More

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http://dx.doi.org/10.1159/000494921DOI Listing
December 2018
3 Reads

The Effectiveness of a Virtual Reality-Based Tai Chi Exercise on Cognitive and Physical Function in Older Adults with Cognitive Impairment.

Dement Geriatr Cogn Disord 2018 11;46(5-6):358-370. Epub 2018 Dec 11.

Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Tai Chi (TC) is a Chinese mind-body exercise with proven physical and psychological benefits. A modified TC via virtual reality (VR) may be suitable for the elderly owing to the immediate guidance and feedback regarding movement accuracy. This study explored the cognitive and physical effects of a VR-based TC (VRTC) exercise program on older adults with cognitive impairment (CI). Read More

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https://www.karger.com/Article/FullText/494659
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http://dx.doi.org/10.1159/000494659DOI Listing
December 2018
3 Reads
3.547 Impact Factor

Neurofilament Light in Serum and Cerebrospinal Fluid of Hip Fracture Patients with Delirium.

Dement Geriatr Cogn Disord 2018 6;46(5-6):346-357. Epub 2018 Dec 6.

Oslo Delirium Research Group, Department of Geriatric Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Background: Delirium is associated with new-onset dementia, suggesting that delirium pathophysiology involves neuronal injury. Neurofilament light (NFL) is a sensitive biomarker for neuroaxonal injury.

Methods: NFL was measured in cerebrospinal fluid (CSF) (n = 130), preoperative serum (n = 192), and postoperative serum (n = 280) in hip fracture patients, and in CSF (n = 123) and preoperative serum (n = 134) in cognitively normal older adults undergoing elective surgery. Read More

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http://dx.doi.org/10.1159/000494754DOI Listing
December 2018
38 Reads

Systematic Review and Meta-Analysis of Prevalence in Post-Stroke Neurocognitive Disorders in Hospital-Based Studies.

Dement Geriatr Cogn Disord 2018 30;46(5-6):322-334. Epub 2018 Nov 30.

Department of Neurology and Laboratory of Functional Neurosciences (EA 4559), Amiens University Hospital, Amiens, France.

Background/aims: Post-stroke neurocognitive disorders (post-stroke NCD) have been reported with a very variable prevalence.

Methods: Based on a systematic literature search, hospital-based studies published between January 1990 and September 2015 were selected when they reported the prevalence of total, mild, and major post-stroke NCD diagnosed by using specified criteria. Factors affecting prevalence were assessed using meta-regression analysis. Read More

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http://dx.doi.org/10.1159/000492920DOI Listing
November 2018
1 Read

Validation of the Czech Montreal Cognitive Assessment for Mild Cognitive Impairment due to Alzheimer Disease and Czech Norms in 1,552 Elderly Persons.

Dement Geriatr Cogn Disord 2018 4;46(5-6):335-345. Epub 2018 Dec 4.

National Institute of Mental Health, Klecany, Czech Republic.

Background: The Czech version of the Montreal Cognitive Assessment (MoCA-CZ) and delayed recall of 5 words have not been validated in patients with mild cognitive impairment (MCI) due to Alzheimer disease (AD) and compared to norms of a large population.

Method: The MoCA-CZ was administered to 1,600 elderly individuals in 2 groups consisting of 48 patients with MCI due to AD (AD-MCI) and 1,552 normal elderly adults.

Results: MoCA-CZ scores were significantly lower in the AD-MCI patients than in the normal elderly (21 ± 4 vs. Read More

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http://dx.doi.org/10.1159/000494489DOI Listing
December 2018
3 Reads

The Dépistage Cognitif de Québec: A New Clinician's Tool for Early Recognition of Atypical Dementia.

Dement Geriatr Cogn Disord 2018 27;46(5-6):310-321. Epub 2018 Nov 27.

Clinique Interdisciplinaire de Mémoire (CIME), Département des Sciences Neurologiques, CHU de Québec, Faculté de médecine, Université Laval, Québec, Québec, Canada,

Introduction: Early recognition of atypical dementia remains challenging partly because of lack of cognitive screening instruments precisely tailored for this purpose.

Methods: We assessed the validity and reliability of the Dépistage Cognitif de Québec (DCQ; www.dcqtest. Read More

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http://dx.doi.org/10.1159/000494348DOI Listing
November 2018
13 Reads

Factors Associated with the Caregivers' Desire to Institutionalize Persons with Dementia: A Cross-Sectional Study.

Dement Geriatr Cogn Disord 2018 19;46(5-6):298-309. Epub 2018 Nov 19.

Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.

Background/aims: Dementia is one of the main reasons for institutionalization among the elderly. Few studies have explored factors associated with the caregivers' (CG) desire to institutionalize (DTI) a person with dementia (PWD). The objective of this study is to identify modifiable and non-modifiable psychosocial and sociodemographic factors associated with a caregiver's DTI. Read More

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http://dx.doi.org/10.1159/000494023DOI Listing
November 2018
14 Reads

A Review: Mealtime Difficulties following Frontotemporal Lobar Degeneration.

Dement Geriatr Cogn Disord 2018 13;46(5-6):285-297. Epub 2018 Nov 13.

Centre for Neuroscience of Speech, The University of Melbourne, Melbourne, Victoria, Australia,

Background: Frontotemporal lobar degeneration (FTLD) can result in a decline in behavior, language, and motor function. Mealtime disturbances are a common and significant outcome of FTLD. Disturbances during mealtimes can arise from dysphagia or may occur secondary to behavioral changes such as rapid eating, mealtime rigidity, and altered diet preferences. Read More

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http://dx.doi.org/10.1159/000494210DOI Listing
November 2018
3 Reads

Perceptual Inhibition Associated with Sensory Integration for Balance in Older Adults.

Dement Geriatr Cogn Disord 2018 7;46(5-6):266-274. Epub 2018 Nov 7.

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Aims: Inhibition associated with perception has been implicated in sensory integration processes for balance when sensory conflict occurs. The current study examines the associations of three measures of inhibition (perceptual inhibition, motor inhibition, and Stroop interference) with standing balance under sensory conflict conditions in younger and older adults.

Methods: Perceptual inhibition, motor inhibition, and Stroop interference were measured in younger and older subjects. Read More

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http://dx.doi.org/10.1159/000493748DOI Listing
November 2018
2 Reads

EEG and Clinical Factors Associated with Mild Cognitive Impairment in Coronary Artery Disease Patients.

Dement Geriatr Cogn Disord 2018 7;46(5-6):275-284. Epub 2018 Nov 7.

Department of Multifocal Atherosclerosis, Federal State Budgetary Institution "Research Institute for Complex Issues of Cardiovascular Diseases", Kemerovo, Russian Federation.

Background: Although an impaired cognitive status in patients with coronary artery disease (CAD) is not rare, the neurophysiological and clinical indicators of mild cognitive impairment (MCI) have been insufficiently investigated so far.

Methods: EEG and neuropsychological testing as well as clinical examination were performed on 122 patients with CAD, who were divided into two groups, those with MCI (n = 60; mean age 57.4 ± 5. Read More

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https://www.karger.com/Article/FullText/493787
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http://dx.doi.org/10.1159/000493787DOI Listing
November 2018
9 Reads

Neuropsychological Criteria for Mild Cognitive Impairment in the Framingham Heart Study's Old-Old.

Dement Geriatr Cogn Disord 2018 2;46(5-6):253-265. Epub 2018 Nov 2.

Veteran Affairs San Diego Healthcare System, San Diego, California, USA,

Background/aims: Mild cognitive impairment (MCI) lacks a "gold standard" operational definition. The Jak/Bondi actuarial neuropsychological criteria for MCI are associated with improved diagnostic stability and prediction of progression to dementia compared to conventional MCI diagnostic approaches, although its utility in diagnosing MCI in old-old individuals (age 75+) is unknown. Therefore, we investigated the applicability of neuropsychological MCI criteria among old-old from the Framingham Heart Study. Read More

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http://dx.doi.org/10.1159/000493541DOI Listing
November 2018
20 Reads
3.550 Impact Factor

Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties.

Dement Geriatr Cogn Disord 2018 23;46(3-4):243-252. Epub 2018 Oct 23.

Center for Neurocognition and Theoretical Syntax, Scuola Universitaria Superiore IUSS Pavia, Pavia,

Background: We evaluated the psychometric proprieties of the Screening for Aphasia in NeuroDegeneration (SAND) battery in Italian primary progressive aphasia (PPA) and movement disorder (MD) patients.

Methods: The sample included 30 consecutive PPA and 45 MD patients who completed the SAND battery together with a clinical interview and a neurological/neuropsychological examination and 130 healthy controls (HC).

Results: The SAND battery showed good internal consistency and good convergent and divergent validity. Read More

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https://www.karger.com/Article/FullText/492632
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http://dx.doi.org/10.1159/000492632DOI Listing
January 2019
28 Reads

Alterations in Intra- and Interregional Intrinsic Brain Connectivity Are Differentially Associated with Memory Performance in Amnestic Mild Cognitive Impairment.

Dement Geriatr Cogn Disord 2018 19;46(3-4):229-242. Epub 2018 Oct 19.

Department of Psychiatry, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of

Background: Previous research has separated spatial patterns of intra- and interregional intrinsic brain connectivity, as evaluated by regional homogeneity (ReHo) and functional connectivity (FC), respectively, in prodromal Alzheimer's disease (AD). Moreover, the intra- and interregional intrinsic brain connectivities have been demonstrated to have a significant relationship with each other.

Objective: To explore FCs from brain regions which display a difference in ReHo between an amnestic mild cognitive impairment (aMCI) group and healthy controls (HC) and to examine the relationship of intra- and interregional intrinsic brain connectivity to cognitive function in both groups. Read More

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https://www.karger.com/Article/FullText/493167
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http://dx.doi.org/10.1159/000493167DOI Listing
January 2019
26 Reads

An Informant-Based Simple Questionnaire for Language Assessment in Neurodegenerative Disorders.

Dement Geriatr Cogn Disord 2018 18;46(3-4):207-216. Epub 2018 Oct 18.

Department of Neurology, Show Chwan Memorial Hospital, Changhua,

Background/aims: Language dysfunction is a crucial feature of brain disorders. This study investigated language dysfunction in patients with dementia with or without parkinsonism by using an informant-based simple questionnaire.

Methods: Language dysfunction in normal controls (NCs), and patients with Parkinson disease (PD), Parkinson disease dementia (PDD), dementia with Lewy bodies (DLB), or Alzheimer disease (AD) were analyzed and compared. Read More

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https://www.karger.com/Article/FullText/493540
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http://dx.doi.org/10.1159/000493540DOI Listing
January 2019
11 Reads

The Validity of the Norwegian Version of the Cognitive Function Instrument.

Dement Geriatr Cogn Disord 2018 18;46(3-4):217-228. Epub 2018 Oct 18.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Background/aims: A timely diagnosis of dementia is important, and the Cognitive Function Instrument (CFI) is a newly developed instrument to screen for cognitive decline. The aim of this study was to evaluate the validity and internal consistency of the Norwegian version of the CFI.

Methods: We included 265 participants with dementia, mild cognitive impairment (MCI), subjective cognitive impairment (SCI), and a reference group without subjective or assessed cognitive decline. Read More

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https://www.karger.com/Article/FullText/493463
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http://dx.doi.org/10.1159/000493463DOI Listing
January 2019
10 Reads

Diabetes, but Not Hypertension and Obesity, Is Associated with Postoperative Cognitive Dysfunction.

Dement Geriatr Cogn Disord 2018 16;46(3-4):193-206. Epub 2018 Oct 16.

Molecular Epidemiology Research Group, Max-Delbrueck-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin, Germany.

Background/aims: Older people undergoing surgery are at risk of developing postoperative cognitive dysfunction (POCD), but little is known of risk factors predisposing patients to POCD. Our objective was to estimate the risk of POCD associated with exposure to preoperative diabetes, hypertension, and obesity.

Methods: Original data from 3 randomised controlled trials (OCTOPUS, DECS, SuDoCo) were obtained for secondary analysis on diabetes, hypertension, baseline blood pressure, obesity (BMI ≥30 kg/m2), and BMI as risk factors for POCD in multiple logistic regression models. Read More

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https://www.karger.com/Article/FullText/492962
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http://dx.doi.org/10.1159/000492962DOI Listing
January 2019
19 Reads

Megestrol Acetate Induces Declarative Memory Changes and Cortisol Suppression in Healthy Volunteers.

Dement Geriatr Cogn Disord 2018 4;46(3-4):186-192. Epub 2018 Oct 4.

Background: The effects of the glucocorticoid and progesterone receptor agonist megestrol on declarative memory, and the ability of phenytoin to block these effects, were assessed.

Methods: Healthy volunteers received each medication combination (placebo and megestrol, phenytoin and megestrol, and placebo and placebo) using a randomized, crossover design. The Rey Auditory Verbal Learning Test assessed declarative memory. Read More

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http://dx.doi.org/10.1159/000490789DOI Listing
January 2019
3 Reads

C9orf72 Protein Plasmatic Concentrations Are Similar between C9ORF72 Expansion Carriers and Noncarriers in Frontotemporal Dementia.

Dement Geriatr Cogn Disord 2018 27;46(3-4):180-185. Epub 2018 Sep 27.

Neurochemistry and Neurogenetics Laboratory, Department of Biochemistry, Lyon University Hospital, Bron, France.

Background/aims: The aim of the study was to assess the theory of haploinsufficiency in C9ORF72 expansion carriers, the most frequent causative gene of frontotemporal dementia.

Methods: Plasmatic concentrations of C9orf72 protein were measured in 33 patients suspected of familial frontotemporal dementia using an enzyme-linked immunosorbent assay.

Results: No difference was observed between C9ORF72 expansion carriers (21. Read More

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https://www.karger.com/Article/FullText/492963
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http://dx.doi.org/10.1159/000492963DOI Listing
January 2019
9 Reads

Quantitative Measurements of Motor Function in Alzheimer's Disease, Frontotemporal Dementia, and Dementia with Lewy Bodies: A Proof-of-Concept Study.

Dement Geriatr Cogn Disord 2018 26;46(3-4):168-179. Epub 2018 Sep 26.

Danish Dementia Research Centre, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen,

Background: This study examines the efficacy of using quantitative measurements of motor dysfunction, compared to clinical ratings, in Alzheimer's disease (AD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).

Methods: In this cross-sectional study, 49 patients with a diagnosis of AD (n = 17), FTD (n = 19), or DLB (n = 13) were included and underwent cognitive testing, clinical motor evaluation, and quantitative motor tests: pronation/supination hand tapping, grasping and lifting, and finger and foot tapping.

Results: Our results revealed significantly higher Q-Motor values in pronation/supination and in grip lift force assessment in AD, FTD, and DLB compared to healthy controls (HC). Read More

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http://dx.doi.org/10.1159/000492860DOI Listing
January 2019
5 Reads

Late-Life Depression versus Amnestic Mild Cognitive Impairment: Alzheimer's Disease Incidence in 4 Years of Follow-Up.

Dement Geriatr Cogn Disord 2018 10;46(3-4):140-153. Epub 2018 Sep 10.

Complex Unit of Geriatrics, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy.

Background/aim: The aim of the study was to evaluate the prognostic power of late-life depression (LLD) compared with amnestic mild cognitive impairment (aMCI) for the onset of Alzheimer's disease (AD) within 4 years of follow-up.

Methods: We estimated the incidence of AD in 60 patients presenting with aMCI, 115 patients suffering of LLD treated with antidepressants with good compliance, and 66 healthy control (HC) patients, followed for 4 years.

Results: The risk to develop AD, within 4 years, was 68. Read More

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http://dx.doi.org/10.1159/000492489DOI Listing
January 2019
16 Reads

A Review of Diagnostic Impact of Amyloid Positron Emission Tomography Imaging in Clinical Practice.

Dement Geriatr Cogn Disord 2018 10;46(3-4):154-167. Epub 2018 Sep 10.

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland,

Background: Molecular imaging of brain amyloid for the diagnosis of Alzheimer's disease (AD) using positron emission tomography (PET) has been approved for use in clinical practice by the Food and Drug Administration (FDA) since 2012. However, the clinical utility and diagnostic impact of amyloid PET imaging remain controversial. We conducted a review of the recent studies investigating clinical utility of amyloid PET imaging with focus on changes in diagnosis, diagnostic confidence, and patient management. Read More

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http://dx.doi.org/10.1159/000492151DOI Listing
January 2019
9 Reads

A Dementia Café as a Bridgehead for Community-Inclusive Care: Qualitative Analysis of Observations by On-the-Job Training Participants in a Dementia Café.

Dement Geriatr Cogn Disord 2018 4;46(3-4):128-139. Epub 2018 Sep 4.

Faculty of Social Studies, Doshisha University, Kyoto, Japan.

Background/aims: Dementia cafés are becoming widespread as a new approach to dementia care, but their operational procedures and significance have not been adequately studied.

Methods: On-the-job training (OJT) for professionals planning to operate a dementia café in the future was conducted in a pioneering dementia café in Japan. The reports of OJT trainees' observations and learning were analyzed qualitatively. Read More

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http://dx.doi.org/10.1159/000492174DOI Listing
January 2019
8 Reads

Psychometric Properties and Factor Analysis of the Engagement and Independence in Dementia Questionnaire (EID-Q).

Dement Geriatr Cogn Disord 2018 4;46(3-4):119-127. Epub 2018 Sep 4.

Research Department of Clinical, Educational and Health Psychology, University College London, London, United Kingdom.

Background/aims: Independence and social engagement are important outcomes for people with dementia. The aim of this study was to conduct an in-depth psychometric assessment of the Engagement and Independence in Dementia Questionnaire (EID-Q), a measure of social independence.

Methods: This was an observational study at five NHS sites across England. Read More

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http://dx.doi.org/10.1159/000488484DOI Listing
January 2019
3 Reads

Psychometric Validation of the Czech Version of the Quality of Life - Alzheimer's Disease Scale in Patients with Early-Stage Dementia.

Dement Geriatr Cogn Disord 2018 24;46(1-2):109-118. Epub 2018 Aug 24.

Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Background/aims: The aim of this study was to perform a psychometric validation of the Czech version of the Quality of Life - Alzheimer's Disease scale (QoL-AD) for patients with early-stage dementia.

Methods: The sample included 212 patient-proxy pairs. For convergent validity, the Czech version of the Bristol Activities of Daily Living Scale (BADLS-CZ), the Short Physical Performance Battery (SPPB), and the Geriatric Depression Scale (GDS) were used. Read More

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http://dx.doi.org/10.1159/000492490DOI Listing
November 2018
17 Reads

Parietal Involvement in Constructional Apraxia as Measured Using the Pentagon Copying Task.

Dement Geriatr Cogn Disord 2018 24;46(1-2):50-59. Epub 2018 Aug 24.

Department of Neurology, Erasmus MC University Medical Centre, Rotterdam, the Netherlands.

Deficits in copying ("constructional apraxia") is generally defined as a multifaceted deficit. The exact neural correlates of the different types of copying errors are unknown. To assess whether the different categories of errors on the pentagon drawing relate to different neural correlates, we examined the pentagon drawings of the MMSE in persons with subjective cognitive complaints, mild cognitive impairment, or early dementia due to Alzheimer's disease. Read More

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http://dx.doi.org/10.1159/000491634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187841PMC
November 2018
6 Reads

Effects of Physical Activity in Nursing Home Residents with Dementia: A Randomized Controlled Trial.

Dement Geriatr Cogn Disord 2018 24;46(1-2):60-80. Epub 2018 Aug 24.

Department of Clinical Neuropsychology, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Background/aims: There is no consensus regarding the optimal nonpharmacological intervention to slow down dementia-related decline. We examined whether physical stimulation interventions were effective in reducing cognitive, physical, mood, and behavioral decline in nursing home residents with dementia.

Methods: Eighty-seven nursing home residents with dementia were randomly assigned to 3 physical activity interventions: activities of daily living (ADL) training, multicomponent exercise training, or combined multicomponent exercise and ADL training. Read More

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http://dx.doi.org/10.1159/000491818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187838PMC
November 2018
3 Reads

Do Reports on Personal Preferences of Persons with Dementia Predict Their Responses to Group Activities?

Dement Geriatr Cogn Disord 2018 24;46(1-2):100-108. Epub 2018 Aug 24.

Background: We examine the utility of individualizing activities for persons with dementia (PwD) on the basis of congruence with preferences. Previous studies demonstrated only limited evidence of individualization of activity content to improve response, tended not to consider group activities, or were inconclusive.

Methods: Participants were 90 PwD residing in a nursing home or attending a day center. Read More

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http://dx.doi.org/10.1159/000491746DOI Listing
November 2018
1 Read

Midlife Stress in Relation to Late-Life Cerebrospinal Fluid Biomarkers of Alzheimer's Disease: A 25-Year Follow-Up Study.

Dement Geriatr Cogn Disord 2018 24;46(1-2):90-99. Epub 2018 Aug 24.

Department of Psychiatry and Neurochemistry, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap), University of Gothenburg, Gothenburg, Sweden.

Background/aims: Psychological stress has previously been associated with higher risk of developing late-life dementia, especially Alzheimer's disease (AD). This study tested whether longstanding midlife stress is related to cerebrospinal fluid (CSF) biomarkers of late-life AD, such as tau protein and amyloid beta (Aβ).

Methods: The study included 79 nondemented females from the Prospective Population Study of Women in Gothenburg, Sweden, who responded to a standardized stress question at baseline (mean age 49 years) and underwent a lumbar puncture at follow-up 25 years later. Read More

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http://dx.doi.org/10.1159/000490885DOI Listing
November 2018
2 Reads

Dementia Patients Are More Sedentary and Less Physically Active than Age- and Sex-Matched Cognitively Healthy Older Adults.

Dement Geriatr Cogn Disord 2018 24;46(1-2):81-89. Epub 2018 Aug 24.

Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.

Aims: The aim of this study was to examine physical activity and sedentary behaviour characteristics of ambulatory and community-dwelling patients with dementia compared to cognitively healthy age-, sex- and weight-matched controls.

Methods: In this cross-sectional study, we included community-dwelling dementia patients (n = 45, age 79.6 ± 5. Read More

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http://dx.doi.org/10.1159/000491995DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6187840PMC
November 2018
20 Reads

Cognitive Therapy for Dementia Patients: A Systematic Review.

Dement Geriatr Cogn Disord 2018 9;46(1-2):1-26. Epub 2018 Aug 9.

UOC eHealth Center (eHC), Universitat Oberta de Catalunya (UOC), Barcelona, Spain.

Background: Cognitive therapy is a well-established intervention for treating elderly suffering from dementia. In particular, reality orientation and skills training seem to be effective interventions for reversing cognitive impairment among elderly, although findings are inconclusive. Therefore, a systematic update of the existing evidence of cognitive therapy for people suffering from dementia is needed. Read More

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http://dx.doi.org/10.1159/000490851DOI Listing
November 2018
10 Reads

A Point Prevalence Study of Delirium in Italian Nursing Homes.

Dement Geriatr Cogn Disord 2018 9;46(1-2):27-41. Epub 2018 Aug 9.

Geriatric Research Group, Brescia, Italy.

Background: Delirium is a common geriatric syndrome. Few studies have been conducted in nursing home (NH) residents. The aim of this project was to perform a point prevalence study of delirium in Italian NHs. Read More

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http://dx.doi.org/10.1159/000490722DOI Listing
November 2018
28 Reads

The Head Turning Sign in Dementia and Mild Cognitive Impairment: Its Relationship to Cognition, Behavior, and Cerebrospinal Fluid Biomarkers.

Dement Geriatr Cogn Disord 2018 9;46(1-2):42-49. Epub 2018 Aug 9.

Neurology Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Background/aims: The head turning sign (HTS) is frequently noticed in clinical practice, but few studies have investigated its etiological and neuropsychological correlates.

Methods: The presence and frequency of the HTS was operationalized and prospectively evaluated in patients with Alzheimer's disease (AD), amnestic mild cognitive impairment (MCI), and behavioral-variant frontotemporal dementia (bvFTD). Cerebrospinal fluid (CSF) samples for AD biomarkers were collected. Read More

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http://dx.doi.org/10.1159/000486531DOI Listing
November 2018
1 Read

Effect of Apolipoprotein E ɛ4 Carrier Status on Cognitive Response to Acetylcholinesterase Inhibitors in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.

Dement Geriatr Cogn Disord 2018 24;45(5-6):335-352. Epub 2018 Jul 24.

Department of Psychiatry, Taipei City Psychiatric Center, Taipei City Hospital, Taipei, Taiwan.

Background: The apolipoprotein E ɛ4 (APOE ɛ4) genotype is the major genetic risk factor for Alzheimer's disease (AD). However, its effect on an individual's response to treatment is less well understood. Many studies have reported that the presence or absence of APOE ɛ4 may have influence on the therapeutic response for acetylcholinesterase inhibitors (AChEIs), but the results were inconsistent. Read More

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http://dx.doi.org/10.1159/000490175DOI Listing
February 2019
2 Reads
3.550 Impact Factor

Quantitative Mobility Assessment for Fall Risk Prediction in Dementia: A Systematic Review.

Dement Geriatr Cogn Disord 2018 24;45(5-6):353-367. Epub 2018 Jul 24.

Toronto Rehabilitation Institute - University Health Network, Toronto, Ontario, Canada.

Background: Impairments of gait and balance often progress through the course of dementia, and are associated with increased risk of falls.

Summary: This systematic review provides a critical analysis of the evidence linking quantitative measures of gait and balance to fall risk in older adults with dementia. Various instrumented measures of gait and postural stability including gait speed and non-instrumented performance measures including Timed Up and Go were shown to be capable of distinguishing fallers from non-fallers. Read More

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http://dx.doi.org/10.1159/000490850DOI Listing
February 2019
3 Reads

Combined Exercise and Cognitive Training System for Dementia Patients: A Randomized Controlled Trial.

Dement Geriatr Cogn Disord 2018 23;45(5-6):318-325. Epub 2018 Jul 23.

Sanyo Global Partners, Inc., Shunan, Japan.

Background/aims: We investigated the efficacy of a combined exercise and cognitive training system that we devised for improvement of attention and concentration, cognition, and activities of daily living in older adults with dementia.

Methods: A total of 100 dementia patients were randomly assigned to an intervention group or a control group. The intervention group was subjected to a combined exercise and cognitive training for 6 consecutive weeks. Read More

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http://dx.doi.org/10.1159/000490613DOI Listing
February 2019
31 Reads

Clock Drawing Test: A Simple Scoring System for the Accurate Screening of Cognitive Impairment in Patients with Mild Cognitive Impairment and Dementia.

Dement Geriatr Cogn Disord 2018 23;45(5-6):326-334. Epub 2018 Jul 23.

School of Advanced Social Studies, Nova Gorica, Slovenia.

Background/aim: The Clock Drawing Test (CDT) is a valid alternative screening tool to the Mini-Mental State Examination (MMSE) and, crucially, it may be completed faster. The aim of our study was to standardize and simplify the CDT scoring system for screening in three common conditions: mild cognitive impairment (MCI), Alzheimer's disease (AD) and mixed dementia (MD).

Methods: We included 188 subjects (43 healthy volunteers, 49 patients with MCI, 54 patients with AD, and 42 patients with MD), who performed the MMSE and CDT. Read More

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http://dx.doi.org/10.1159/000490381DOI Listing
February 2019
3 Reads

MACE for the Diagnosis of Dementia and MCI: 3-Year Pragmatic Diagnostic Test Accuracy Study.

Dement Geriatr Cogn Disord 2018 11;45(5-6):300-307. Epub 2018 Jul 11.

Background/aims: The Mini-Addenbrooke's Cognitive Examination (MACE) is a relatively new short cognitive screening instrument for the detection of patients with dementia and mild cognitive impairment (MCI). Few studies of the MACE have been reported hitherto. The aim of this study was to undertake a pragmatic diagnostic test accuracy study of MACE in a large cohort of patients seen in a dedicated cognitive disorders clinic. Read More

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http://dx.doi.org/10.1159/000484438DOI Listing
February 2019
23 Reads

The Pentagon Copying Test and the Clock Drawing Test as Prognostic Markers in Dementia with Lewy Bodies.

Dement Geriatr Cogn Disord 2018 11;45(5-6):308-317. Epub 2018 Jul 11.

Department of Neurology and Alzheimer Center, Erasmus Medical Center, Rotterdam, the Netherlands.

Aims: To determine whether the pentagon copying test (PCT) and the clock drawing test (CDT) are associated with nursing home admission or survival in dementia with Lewy bodies (DLB).

Methods: The PCT and/or the CDT were retrospectively collected from 103 clinically diagnosed probable DLB patients at a university medical center and general hospital. Patients with high versus low scores on these tests were compared. Read More

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http://dx.doi.org/10.1159/000490045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6159833PMC
February 2019
2 Reads

Influence of Age and Education on the Performance of Elderly in the Brazilian Version of the Montreal Cognitive Assessment Battery.

Dement Geriatr Cogn Disord 2018 11;45(5-6):290-299. Epub 2018 Jul 11.

Aims: To provide normative data for the Brazilian version of the Montreal Cognitive Assessment (MoCA-BR) and to measure the effect of sociodemographic variables on the cognitive performance of cognitively healthy elderly people.

Methods: A sample of 110 cognitively healthy individuals, aged over 65 years, with at least 4 years of schooling were recruited from 3 health care centers for the elderly in Recife, Brazil. The cognitive performance was assessed using MoCA-BR. Read More

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http://dx.doi.org/10.1159/000489774DOI Listing
February 2019
2 Reads

Increasing the Sensitivity of Functional Status Assessment in the Preclinical Range (Normal to Mild Cognitive Impairment): Exploring the IADL-Extended Approach.

Dement Geriatr Cogn Disord 2018 11;45(5-6):282-289. Epub 2018 Jul 11.

Cognitive Neuroscience Division, Department of Neurology and Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York, USA.

Background/aims: Dementia exhibits an insidious onset consisting of cognitive, behavioral, and functional impairment. We explored a functional continuum that extends assessment beyond the clinical instrumental activities of daily living (IADL) range and into advanced activities of daily living.

Methods: We examined the predictive power (Cox regression; n = 2,471) of a unidimensional IADL-extended (IADL-x) scale for incident mild cognitive impairment (MCI). Read More

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http://dx.doi.org/10.1159/000487632DOI Listing
February 2019
4 Reads