189,602 results match your criteria Dementia With Lewy Bodies


The Effectiveness of a Virtual Reality-Based Tai Chi Exercise on Cognitive and Physical Function in Older Adults with Cognitive Impairment.

Dement Geriatr Cogn Disord 2018 Dec 11;46(5-6):358-370. Epub 2018 Dec 11.

Department of Physical Therapy and Graduate Institute of Rehabilitation Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan.

Background: Tai Chi (TC) is a Chinese mind-body exercise with proven physical and psychological benefits. A modified TC via virtual reality (VR) may be suitable for the elderly owing to the immediate guidance and feedback regarding movement accuracy. This study explored the cognitive and physical effects of a VR-based TC (VRTC) exercise program on older adults with cognitive impairment (CI). Read More

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December 2018

Fluid and PET biomarkers for amyloid pathology in Alzheimer's disease.

Mol Cell Neurosci 2018 Dec 8. Epub 2018 Dec 8.

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden; Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, University College, London, United Kingdom of Great Britain and Northern Ireland; Department of Molecular Neuroscience, UCL Institute of Neurology, United Kingdom of Great Britain and Northern Ireland; UK Dementia Research Institute at UCL, United Kingdom of Great Britain and Northern Ireland.

Alzheimer's disease (AD) is characterized by amyloid plaques and tau pathology (neurofibrillary tangles and neuropil threads). Amyloid plaques are primarily composed of aggregated and oligomeric β-amyloid (Aβ) peptides ending at position 42 (Aβ42). The development of fluid and PET biomarkers for Alzheimer's disease (AD), has allowed for detection of Aβ pathology in vivo and marks a major advancement in understanding the role of Aβ in Alzheimer's disease (AD). Read More

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December 2018

Psychosocial interventions for pain management in older adults with dementia: a systematic review of randomised controlled trials.

J Adv Nurs 2018 Dec 10. Epub 2018 Dec 10.

School of Nursing and Midwifery & Menzies Health Institute Queensland, Griffith University, Australia.

Aim: To assess the effectiveness of psychosocial interventions on pain in older adults living with dementia.

Design: A systematic review with meta-analysis of randomised controlled trials.

Data Sources: Scopus, ProQuest, EBSCO (CINAHL and MEDLINE), PubMed, OVID (PsycINFO), Web of Science and Cochrane Library were searched from their inception up to 2 May 2018. Read More

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December 2018

Tau PET Imaging for Staging of Alzheimer's Disease in Down Syndrome.

Authors:
Michael S Rafii

Dev Neurobiol 2018 Dec 8. Epub 2018 Dec 8.

Alzheimer's Therapeutic Research Institute (ATRI), Keck School of Medicine, University of Southern California.

Alzheimer's disease (AD) pathology and early-onset dementia develop almost universally in Down syndrome (DS). AD is defined neuropathologically by the presence of extracellular plaques of aggregated amyloid β protein and intracellular neurofibrillary tangles (NFTs) of aggregated hyperphosphorylated tau protein. The development of radiolabeled positron emission tomography (PET) ligands for amyloid plaques and tau tangles enables the longitudinal assessment of the spatial pattern of their accumulation in relation to symptomatology. Read More

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December 2018

Age-Normative MMSE Data for Older Persons Aged 85 to 93 in a Longitudinal Swedish Cohort.

J Am Geriatr Soc 2018 Dec 10. Epub 2018 Dec 10.

Geriatric Medicine, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

Background/objectives: Normative Mini-mental state examination (MMSE) reference values in elderly are scarce. Therefore, the aim is to present normative MMSE values for 85-93 year olds.

Design: A longitudinal age cohort study. Read More

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December 2018

Safeguarding older adults with dementia, depression, and delirium in a temporary disaster shelter.

Nurs Forum 2018 Dec 9. Epub 2018 Dec 9.

Center of Innovation in Long-Term Services and Supports, Providence VA Medical Center, Providence, RI.

Natural disasters impact people of every age in the communities where they occur, with older adults being a vulnerable subset of the population. Most disaster shelter volunteer nurses are experienced in addressing common health needs of older adult clients such as diabetes, hypertension, and pulmonary disease. These nurses also have the requisite training to respond to more acute medical events, including the symptoms of a heart attack or stroke. Read More

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December 2018

Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case-control study.

Spec Care Dentist 2018 Dec 11. Epub 2018 Dec 11.

Assistant Professor of Linguistics, Department of Persian Literature and English Language, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Aim: The aim of this study was to evaluate acetylcholinesterase (AChE) and pseudocholinesterase (PChE) in whole saliva in patients with Alzheimer's disease (AD) and in healthy subjects. Saliva has a high potential for keeping track of general health and diseases. AD is a type of dementia with reduction in brain cholinergic markers that causes memory, thinking, and behavior problems. Read More

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December 2018

Association of Informal Caregiver Distress with Health Outcomes of Community-Dwelling Dementia Care Recipients: A Systematic Review.

J Am Geriatr Soc 2018 Dec 10. Epub 2018 Dec 10.

Division of Geriatric Medicine, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.

Background: Most dementia care occurs in the community with support from informal caregivers who are often distressed. Dementia caregiver distress is known to be hazardous to the caregiver's health, but the impact on the dementia care recipient is not well known.

Methods: We searched the Medline, Embase, PsycINFO, CINAHL, and Cochrane databases from inception until June 2017 for studies investigating the association of informal caregiver distress with health outcomes of community-dwelling dementia care recipients. Read More

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December 2018

Prevalence of Depression, Anxiety and PTSD in People with Dementia: a Systematic Review and Meta-Analysis.

Neuropsychol Rev 2018 Dec 7. Epub 2018 Dec 7.

School of Psychology, Faculty of Health & Medical Sciences, University of Adelaide, Adelaide, South Australia, 5005, Australia.

There appears to be a link between depression/anxiety/PTSD and dementia, although the evidence is incomplete and the reason is unclear. Mental illness may cause dementia or may be prodromal or comorbid with dementia, or dementia may trigger a relapse of symptoms in individuals with a history of mental illness. This study examined the link between depression/anxiety/PTSD and dementia by evaluating the prevalence of these disorders in people with dementia, relative to their healthy peers. Read More

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December 2018

Regression-based normative data and equivalent scores for Trail Making Test (TMT): an updated Italian normative study.

Neurol Sci 2018 Dec 7. Epub 2018 Dec 7.

Department of Psychology, University of Campania "Luigi Vanvitelli", Viale Ellittico 31, 81100, Caserta, Italy.

Objectives: The Trail Making Test (TMT) is widely used to assess psychomotor speed and attentional set-shifting. Since the regression-based norms and equivalent scores (ESs) for the TMT Italian version trace back to more than 20 years ago, we aimed at providing updated normative data for basic (Part A and Part B) and derived (Score B-A and Score B/A) TMT scores collected in a larger sample with an extended age range.

Methods: Three hundred fifty-five Italian volunteers stratified for sex (166 men), age decades (age range 20-90 years), and educational level (from primary school to university) completed the TMT and the Montreal Cognitive Assessment (MoCA). Read More

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December 2018

The complexity of neuroinflammation consequent to traumatic brain injury: from research evidence to potential treatments.

Acta Neuropathol 2018 Dec 7. Epub 2018 Dec 7.

Wicking Dementia Research and Education Centre, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.

This review recounts the definitions and research evidence supporting the multifaceted roles of neuroinflammation in the injured brain following trauma. We summarise the literature fluctuating from the protective and detrimental properties that cytokines, leukocytes and glial cells play in the acute and chronic stages of TBI, including the intrinsic factors that influence cytokine responses and microglial functions relative to genetics, sex, and age. We elaborate on the pros and cons that cytokines, chemokines, and microglia play in brain repair, specifically neurogenesis, and how such conflicting roles may be harnessed therapeutically to sustain the survival of new neurons. Read More

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December 2018

Approaches to Deprescribing Psychotropic Medications for Changed Behaviours in Long-Term Care Residents Living with Dementia.

Drugs Aging 2018 Dec 11. Epub 2018 Dec 11.

Dementia Centre for Research Collaboration, School of Psychiatry, UNSW Sydney, Sydney, NSW, Australia.

Psychotropic medications have a high risk of serious adverse events and small effect size for changed behaviours for people with dementia. Non-pharmacological approaches are recommended as first-line treatment for changed behaviours, yet psychotropic medications remain highly prevalent in long-term aged care settings. This narrative review describes the current evidence regarding deprescribing psychotropic medications for people with dementia in long-term care. Read More

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December 2018

Evaluating risk factors following surgery for periprosthetic fractures around hip and knee arthroplasties.

Arch Orthop Trauma Surg 2018 Dec 7. Epub 2018 Dec 7.

Trauma and Orthopaedics, University Hospitals of North Midlands NHS Trust, Royal Stoke Hospital, Newcastle Road, Stoke-on-Trent, ST4 6QG, UK.

Background: The increasing demand for arthroplasty has resulted in an inevitable rise in the number of periprosthetic fractures around implants. Survival factors looking into patient's comorbidities and how they influence outcome are rare. This study aims to identify correlations between survival post-injury and pre-existing comorbidities. Read More

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December 2018

Factors influencing attrition in 35 Alzheimer's Disease Centers across the USA: a longitudinal examination of the National Alzheimer's Coordinating Center's Uniform Data Set.

Aging Clin Exp Res 2018 Dec 10. Epub 2018 Dec 10.

Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, FL, 33140, USA.

Objective: A lack of understanding of the causes of attrition in longitudinal studies of older adults may lead to higher attrition rates and bias longitudinal study results. In longitudinal epidemiological studies of Alzheimer's disease and related dementias, high rates of attrition may cause a systematic underestimation of dementia prevalence and skew the characterization of the disease. This can compromise the generalizability of the study results and any inferences based on the surviving sample may grossly misrepresent the importance of the risk factors for dementia. Read More

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December 2018

The Alzheimer's Poetry Project.

JAMA 2018 Dec;320(22):2294-2295

School of Social Work, Adelphi University, Garden City, New York.

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December 2018

Bioaccumulation of polystyrene nanoplastics and their effect on the toxicity of Au ions in zebrafish embryos.

Nanoscale 2018 Dec 10. Epub 2018 Dec 10.

Hazards Monitoring Bionano Research Center, Korea Research Institute of Bioscience and Biotechnology, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea. and KRIBB School, University of Science and Technology, 125 Gwahak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.

As nano- and micro-sized plastics accumulate in the environment and the food chain of animals, including humans, it is imperative to assess the effects of nanoplastics in living organisms in a systematic manner, especially because of their ability to adsorb potential toxicants such as pollutants, heavy metals, and organic macromolecules that coexist in the environment. Using the zebrafish embryo as an animal model, we investigated the bioaccumulation and in vivo toxicity of polystyrene (PS) nanoplastics individually or in combination with the Au ion. We showed that smaller PS nanoplastics readily penetrated the chorion and developing embryos and accumulated throughout the whole body, mostly in lipid-rich regions such as in yolk lipids. Read More

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December 2018

Setting matters: Associations of nurses' attitudes towards people with dementia.

Nurs Open 2019 Jan 12;6(1):155-161. Epub 2018 Oct 12.

Institute on Ageing University of Applied Sciences Bern Switzerland.

Aim: Identify associations between attitudes of nurses towards people with dementia and their socio-demographic (age and gender) and work-related characteristics (employment, work experience, nursing degree, care setting).

Design: The study was designed in a cross-sectional way, collecting self-reported questionnaire data.

Methods: Nurses ( = 417) completed the 20-item Dementia Attitude Scale questionnaire, including socio-demographic and work characteristics. Read More

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January 2019

Rare variants in patients with frontotemporal dementia and amyotrophic lateral sclerosis in a Chinese cohort.

Transl Neurodegener 2018 4;7:31. Epub 2018 Dec 4.

1Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Rd, Changsha, 410008 China.

Background: The TANK-Binding Kinase 1 () gene has recently been identified as the third or fourth most frequent cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The aim of this study was to assess the genetic contribution of in a Chinese cohort.

Methods: A total of 270 cases with ALS, FTD, or their combination were recruited into this study. Read More

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December 2018

Kinetic Modeling of pH-Dependent Oxidation of Dopamine by Iron and Its Relevance to Parkinson's Disease.

Front Neurosci 2018 26;12:859. Epub 2018 Nov 26.

Water Research Centre, School of Civil and Environmental Engineering, The University of New South Wales, Sydney, NSW, Australia.

Parkinson's disease is the second most common neurodegenerative disease. While age is the most significant risk factor, the exact cause of this disease and the most effective approaches to mitigation remain unclear. It has long been proposed that dopamine may play a role in the pathology of Parkinson's disease in view of its ability to generate both protein-modifying quinones such as aminochrome and reactive oxygen species, especially in the presence of pathological iron accumulation in the primary site of neuron loss. Read More

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November 2018

Prevalence and Predictors of Abuse in Elderly Patients with Depression at a Tertiary Care Centre in Saurashtra, India.

Indian J Psychol Med 2018 Nov-Dec;40(6):528-533

Department of Psychiatry, M. P. Shah Government Medical College, Jamnagar, Gujarat, India.

Context: Elder abuse has devastating consequences such as poor quality of life, psychological distress and loss of property and security. Abuse of elderly patients with depression has not been adequately researched in India.

Aims: To explore the prevalence and predictors of abuse and its relation to various sociodemographic variables in elderly patients with depression. Read More

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December 2018

Non-coding RNA influences in dementia.

Noncoding RNA Res 2018 Dec 29;3(4):188-194. Epub 2018 Sep 29.

Dept. of Pathology, Faculty of Medicine and Surgery, University of Malta, Msida, MSD 2080, Malta.

Dementia is a complex clinical syndrome characterised by progressive decline in cognitive function. It usually presents itself as impairment in memory, loss of judgement, abstract thinking and other disturbances that are severe enough to interfere with activities of daily living. It has long been considered as one of the major challenges at present posing an ever-increasing demand on global health and social care systems. Read More

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December 2018

Non-coding RNA in -related amyotrophic lateral sclerosis and frontotemporal dementia: A perfect storm of dysfunction.

Noncoding RNA Res 2018 Dec 10;3(4):178-187. Epub 2018 Sep 10.

Wessex Clinical Genetics Service, University Hospital Southampton NHS Foundation Trust, Southampton, UK.

A hexanucleotide repeat expansion in the first intron/promoter region of is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Both sense and antisense transcripts exist at the locus but the function of the antisense lncRNA is unknown. RNA toxicity of the transcribed repeat expansion has been implicated in the pathogenesis of -related ALS/FTD, not only through direct sequestration of important RNA binding proteins but also indirectly through non-ATG dependent translation into dipeptide repeats. Read More

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December 2018

Is Alzheimer's Also a Stem Cell Disease? - The Zebrafish Perspective.

Front Cell Dev Biol 2018 23;6:159. Epub 2018 Nov 23.

German Center for Neurodegenerative Diseases (DZNE) Dresden, Helmholtz Association, Dresden, Germany.

Alzheimer's disease (AD) is the most common neurodegenerative disease and is the leading form of dementia. AD entails chronic inflammation, impaired synaptic integrity and reduced neurogenesis. The clinical and molecular onsets of the disease do not temporally overlap and the initiation phase of the cellular changes might start with a complex causativeness between chronic inflammation, reduced neural stem cell plasticity and neurogenesis. Read More

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November 2018

MMP-9 inhibitors impair learning in spontaneously hypertensive rats.

PLoS One 2018 11;13(12):e0208357. Epub 2018 Dec 11.

Department of Neurology, University of New Mexico, Albuquerque, New Mexico, United States of America.

Vascular cognitive impairment dementia (VCID) is a major cause of cognitive loss in the elderly. Matrix metalloproteinases (MMPs) are a family of proteases involved in remodeling the extracellular matrix in development, injury and repair. Blood-brain barrier (BBB) disruption due to inflammation mediated by MMPs is a mechanism of white matter injury. Read More

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December 2018

(L) a Very Potent Antioxidant Attenuates Dementia in Scopolamine Induced Memory Deficit Mice.

Front Pharmacol 2018 23;9:1375. Epub 2018 Nov 23.

Department of Pharmacology, Punjab University College of Pharmacy, University of the Punjab, Lahore, Pakistan.

The objective of the current project was to explore the pharmacotherapeutic role of (L) for the management of dementia. Dementia is considered a global challenge of current century seeking special attention of pharmacologists to explore its best remedies. Methanolic extract of aerial parts of was tested for phytochemical analysis along with free radical scavenging activity. Read More

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November 2018

TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism.

Front Aging Neurosci 2018 23;10:395. Epub 2018 Nov 23.

Fujian Provincial Key Laboratory of Neurodegenerative Disease and Aging Research, Institute of Neuroscience, Medical College, Xiamen University, Xiamen, China.

Alzheimer's disease (AD) is the leading cause of age-related dementia among the elderly population. Recent genetic studies have identified rare variants of the gene encoding the triggering receptor expressed on myeloid cells-2 (TREM2) as significant genetic risk factors in late-onset AD (LOAD). TREM2 is specifically expressed in brain microglia and modulates microglial functions in response to key AD pathologies such as amyloid-β (Aβ) plaques and tau tangles. Read More

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November 2018

Complexity of the Genetics and Clinical Presentation of Spinocerebellar Ataxia 17.

Front Cell Neurosci 2018 23;12:429. Epub 2018 Nov 23.

Ataxia Centre, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, London, United Kingdom.

Spinocerebellar ataxia type 17 (SCA17) is a rare autosomal dominant neurodegenerative disease caused by a CAG repeat expansion in the TATA-box binding protein gene (). The disease has a varied age at onset and clinical presentation. It is distinct from other SCAs for its association with dementia, psychiatric symptoms, and some patients presenting with chorea. Read More

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November 2018

Thirty-year trends in dementia: a nationwide population study of Swedish inpatient records.

Clin Epidemiol 2018 16;10:1679-1693. Epub 2018 Nov 16.

Aging Research Center, Karolinska Institutet, Stockholm, Sweden,

Background: The continuous growth of the current dementia epidemic is contingent on the stability of age- and sex-specific trends over time. However, recent evidence suggests declining or stable trends. The aim of this study was to evaluate the real-world changes in the burden of dementia in older adults in Sweden from 1987 to 2016 by estimating age- and sex-specific incidence of dementia diagnosis in hospital inpatient records (dementia incidence). Read More

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November 2018

Enzymatic and non-enzymatic pathways of kynurenines' dimerization: the molecular factors for oxidative stress development.

PLoS Comput Biol 2018 Dec 10;14(12):e1006672. Epub 2018 Dec 10.

Laboratory of Neurogenetics, Pavlov Institute of Physiology, Russian Academy of Sciences, Saint-Petersburg, Russia.

Kynurenines, the products of tryptophan oxidative degradation, are involved in multiple neuropathologies, such as Huntington's chorea, Parkinson's disease, senile dementia, etc. The major cause for hydroxykynurenines's neurotoxicity is the oxidative stress induced by the reactive oxygen species (ROS), the by-products of L-3-hydroxykynurenine (L-3HOK) and 3-hydroxyanthranilic acid (3HAA) oxidative self-dimerization. 2-aminophenol (2AP), a structural precursor of L-3HOK and 3HAA, undergoes the oxidative conjugation to form 2-aminophenoxazinone. Read More

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December 2018
1 Read

Depressive symptoms as a barrier to engagement in physical activity in older adults with and without Alzheimer's disease.

PLoS One 2018 7;13(12):e0208581. Epub 2018 Dec 7.

University of Kansas Alzheimer's Disease Center, Fairway, KS, United States of America.

Objectives: Physical activity shows promise for reduced risk of Alzheimer's disease (AD) and protection against cognitive decline among individuals with and without AD. Older adults face many barriers to adoption of physically active lifestyles and people with AD face even further challenges. Physical activity is a promising non-pharmacological approach to improve depressive symptoms, but little is known about the impact of depressive symptoms as a potential barrier to engagement in physical activity. Read More

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December 2018

Olfactory and other sensory impairments in Alzheimer disease.

Authors:
Claire Murphy

Nat Rev Neurol 2018 Dec 10. Epub 2018 Dec 10.

Department of Psychology, San Diego State University, San Diego, CA, USA.

The vast increase in Alzheimer disease (AD) worldwide has grave implications for individuals, family support systems and the health-care systems that will attempt to cope with the disease. Early markers of the disease are essential for efficient selection of clinical trial participants for drug development and for timely treatment once an intervention becomes available. There is avid interest in noninvasive, inexpensive markers that have the potential to identify prodromal AD. Read More

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December 2018

Use of Multimodal Magnetic Resonance Imaging Techniques to Explore Cognitive Impairment in Leukoaraiosis.

Med Sci Monit 2018 Dec 9;24:8910-8915. Epub 2018 Dec 9.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University; China National Clinical Research Center for Neurological Diseases; Center of Stroke, Beijing Institute for Brain Disorders; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China (mainland).

Leukoaraiosis, also referred to as white-matter hyperintensities (WMHs) or age-related white matter changes, is the most frequently seen lesion on brain magnetic resonance images (MRI) in the elderly. LA is a subject of intense research interest, and is correlated with stroke, cognitive impairment or dementia, disturbances, affective disorders, and poor prognoses. Rapid advances in neuroimaging have enabled greater understanding of LA associated with aging-related cognitive decline or dementia. Read More

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December 2018

Reduced Awareness of Memory Deficit is Associated With Increased Medicare Home Health Care Use in Dementia.

Alzheimer Dis Assoc Disord 2018 Dec 6. Epub 2018 Dec 6.

Cognitive Neuroscience Division of the Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the G.H. Sergievsky Center, Columbia University Medical Center.

Objective: The objective of this study was to examine whether reduced awareness of memory deficits in individuals with dementia is associated with more frequent need for Medicare home health care services.

Methods: Cross-sectional analyses were conducted in a multicenter, clinic-based cohort. In total, 192 participants diagnosed with dementia and their informants were independently asked whether or not the participant demonstrated cognitive symptoms of dementia related to memory and word-finding. Read More

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December 2018

Cerebrospinal fluid HIV-1 escape according to different thresholds and underlying comorbidities: is it time to assess the definitions?

AIDS 2018 Nov 27. Epub 2018 Nov 27.

Unit of Infectious Diseases, Department of Medical Sciences, University of Torino, Torino, Italy.

No consensus has been reached on how to define cerebrospinal fluid HIV-1 escape (CSF-E). We describe its prevalence in 1095 paired CSF-plasma HIV-RNA measurements from antiretroviral-treated patients according to several definitions and neurological affections. CSF-E prevalence varied substantially (9. Read More

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November 2018

Decline in handgrip strength from midlife to late-life is associated with dementia in a Japanese community: the Hisayama Study.

J Epidemiol 2018 Dec 8. Epub 2018 Dec 8.

Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University.

Background: The association between decline in handgrip strength from midlife to late-life and dementia is unclear.

Methods: Japanese community-dwellers without dementia aged 60 to 79 (i.e. Read More

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December 2018

MicroRNAs as diagnostic and therapeutic tools for Alzheimer's disease: advances and limitations.

Neural Regen Res 2019 Feb;14(2):242-255

Department of Anatomy, University of Otago, Dunedin, New Zealand.

Alzheimer's disease (AD) is the most common age-related, progressive neurodegenerative disease. It is characterized by memory loss and cognitive decline and responsible for most cases of dementia in the elderly. Late-onset or sporadic AD accounts for > 95% of cases, with age at onset > 65 years. Read More

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February 2019

Working Life Psychosocial Conditions in Relation to Late-Life Cognitive Decline: A Population-Based Cohort Study.

J Alzheimers Dis 2018 Dec 4. Epub 2018 Dec 4.

Department of Neurobiology, Aging Research Center (ARC), Health Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden, and Stockholm University, Sweden.

While the importance of working conditions on cognitive function has been tentatively suggested previously, few studies have considered cumulative effects of exposure throughout the working life. We examined the association between job demand-control status and late-life cognitive decline, taking into account exposure durations. In the population-based cohort study, Swedish National Study on Aging and Care-Kungsholmen, 2,873 dementia-free participants aged 60+ were followed up to nine years. Read More

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December 2018

Next Generation Sequencing Analysis in Early Onset Dementia Patients.

J Alzheimers Dis 2018 Dec 3. Epub 2018 Dec 3.

Genetics Unit, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Background: Early onset dementias (EOD) are rare neurodegenerative dementias that present before 65 years. Genetic factors have a substantially higher pathogenetic contribution in EOD patients than in late onset dementia.

Objective: To identify known and/or novel rare variants in major candidate genes associated to EOD by high-throughput sequencing. Read More

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December 2018

Quality of Life in People with Young-Onset Dementia: A Nordic Two-Year Observational Multicenter Study.

J Alzheimers Dis 2018 Dec 1. Epub 2018 Dec 1.

Norwegian National Advisory Unit on Ageing and Health, Vestfold Hospital Trust, Tønsberg, Norway.

Background: Cross-sectional studies of quality of life (QOL) of people with young-onset dementia shows diverging results.

Objective: To identify factors associated with QOL in people with young-onset Alzheimer's (AD) and frontotemporal dementia (FTD) and explore development in QOL over a two-year period, including differences between the two subtypes.

Methods: A two-year cohort study of 88 community-dwelling people with young-onset AD and FTD recruited from Nordic memory clinics. Read More

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December 2018

In-Out-Test: A New Paradigm for Sorting the Wheat from the Chaff in Prodromal Alzheimer's Disease.

J Alzheimers Dis 2018 Dec 3. Epub 2018 Dec 3.

BarcelonaBeta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Spain.

Background: Assessment of hippocampal amnesia is helpful to distinguish between normal cognition and mild cognitive impairment (MCI), but not for identifying converters to dementia. Here biomarkers are useful but novel neuropsychological approaches are needed in their absence. The In-out-test assesses episodic memory using a new paradigm hypothesized to avoid reliance on executive function, which may compensate for damaged memory networks. Read More

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December 2018
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The role of neurovascular unit damage in the occurrence and development of Alzheimer's disease.

Rev Neurosci 2018 Dec 10. Epub 2018 Dec 10.

Department of Nerve Medical Center, The First Hospital of Changsha, Changsha 410000, China.

Alzheimer's disease (AD) is a neurodegenerative disease with progressive cognitive impairment. It is the most common type of senile dementia, accounting for 65%-70% of senile dementia [Alzheimer's Association (2016). 2016 Alzheimer's disease facts and figures. Read More

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December 2018

Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula.

Neurology 2018 Dec 7. Epub 2018 Dec 7.

From the Departments of Functional Brain Imaging Research (H. Shinotoh, H. Shimada, K.T., S.K., M.O., Y. Kimura, S.H., M.I., N.S., T.S., M.H.) and Radiopharmaceuticals Development (M.-R.Z.), National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, Chiba; Neurology Clinic Chiba (H. Shinotoh); Kii ALS/PDC Research Center (Y. Kokubo), Mie University; Department of Neurology and Gerontology (F.N.), Graduate School of Medical Science, Kyoto Prefectural University of Medicine; Department of Psychiatry (S.K.), Nara Medical University; Division of Neurology (H.E.), Kobe University Graduate School of Medicine, Hyogo; Center for Development of Advanced Medicine for Dementia, Department of Neurology (Y. Kimura), National Institute for Geriatrics and Gerontology, Aichi; Department of Neurology (S.H.), Chiba University; and Department of Neuropathology (M.M.), Institute for Medical Science of Aging, Aichi Medical University, Japan.

Objective: To characterize the distribution of tau pathology in patients with amyotrophic lateral sclerosis/parkinsonism dementia complex on the Kii Peninsula (Kii ALS/PDC) by tau PET using [C]PBB3 as ligand.

Methods: This is a cross-sectional study of 5 patients with ALS/PDC and one asymptomatic participant with a dense family history of ALS/PDC from the Kii Peninsula who took part in this study. All were men, and their age was 76 ± 8 (mean ± SD) years. Read More

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December 2018

Prescribing and testing by primary care providers to assess adherence to the Choosing Wisely Canada recommendations: a retrospective cohort study.

CMAJ Open 2018 Oct-Dec;6(4):E603-E610. Epub 2018 Dec 10.

Departments of Family Medicine (Singer, Kosowan, Katz, Jolin-Dahel, Appel) and Community Health Sciences (Katz, Lix), Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba; Manitoba Primary Care Research Network (Singer); Manitoba Centre for Health Policy (Katz), Winnipeg, Man.; Centre Medical Seine (Jolin-Dahel), Ste. Anne, Man.; Seven Oaks Hospital (Appel), Winnipeg, Man.

Background: Choosing Wisely Canada is an initiative to reduce overprescribing and overtesting. This study assessed adherence to 4 Choosing Wisely Canada recommendations for interventions commonly performed in primary care: (a) antibiotic prescriptions for infections that are probably viral in origin, (b) routine vitamin D tests in low-risk adults, (c) annual screening blood tests and (d) prescriptions of antipsychotic medication to treat symptoms of dementia.

Methods: We conducted a retrospective cohort study of data from the electronic medical records of patients who had an encounter between 2014 and 2016 with a participating Manitoba Primary Care Research Network primary care provider in Manitoba, Canada. Read More

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December 2018

Individual cognitive stimulation therapy for people with intellectual disability and dementia: protocol of a feasibility randomised controlled trial.

BMJ Open 2018 Dec 9;8(12):e022136. Epub 2018 Dec 9.

Division of Psychiatry, University College London, London, UK.

Introduction: Cognitive stimulation therapy (CST) is a psychosocial intervention for dementia. Group CST is effective in reducing cognitive decline and improving quality of life in patients with dementia. There is some evidence that individual CST (iCST) may be beneficial in reducing cognitive decline. Read More

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December 2018

Mobile Health, Information Preferences, and Surrogate Decision-Making Preferences of Family Caregivers of People With Dementia in Rural Hispanic Communities: Cross-Sectional Questionnaire Study.

J Med Internet Res 2018 Dec 10;20(12):e11682. Epub 2018 Dec 10.

School of Information, The University of Texas at Austin, Austin, TX, United States.

Background: Mobile health (mHealth) technology holds promise for promoting health education and reducing health disparities and inequalities in underserved populations. However, little research has been done to develop mHealth interventions for family caregivers of people with dementia, particularly those in rural Hispanic communities, who often serve as surrogate decision makers for their relatives with dementia.

Objective: As part of a larger project to develop and test a novel, affordable, and easy-to-use mHealth intervention to deliver individually tailored materials in rural Hispanic communities, in this pilot study, we aimed to examine (1) characteristics of people with dementia and their family caregivers in rural Hispanic communities, (2) caregivers' preferences for types and amounts of health information and participation in surrogate decision making, and (3) caregivers' mobile device usage and their desire for receiving information via mobile devices. Read More

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December 2018

Chronic intermittent hypoxia induces robust astrogliosis in an Alzheimer's disease-relevant mouse model.

Neuroscience 2018 Dec 6. Epub 2018 Dec 6.

Spinal Cord & Brain Injury Research Center, University of Kentucky, Lexington, KY, United States; Department of Neuroscience, University of Kentucky, Lexington, KY, United States. Electronic address:

Sleep disturbances are a common early symptom of neurodegenerative diseases, including Alzheimer's disease (AD) and other age-related dementias, and emerging evidence suggests that poor sleep may be an important contributor to development of amyloid pathology. Of the causes of sleep disturbances, it is estimated that 10% - 20% of adults in the United States have sleep-disordered breathing (SDB) disorder, with obstructive sleep apnea accounting for the majority of the SBD cases. The clinical and epidemiological data clearly support a link between sleep apnea and AD; yet, almost no experimental research is available exploring the mechanisms associated with this correlative link. Read More

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December 2018

Spatiotemporal analysis for detection of pre-symptomatic shape changes in neurodegenerative diseases: Initial application to the GENFI cohort.

Neuroimage 2018 Dec 6. Epub 2018 Dec 6.

Department of Medical Physics and Biomedical Engineering, University College London, United Kingdom; Dementia Research Centre, Institute of Neurology, University College London, London, WC1N 3BG, United Kingdom; School of Biomedical Engineering and Imaging Sciences, King's College London, United Kingdom.

Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summary volume statistics over the entire structure. Read More

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December 2018

Biomarkers for tau pathology.

Mol Cell Neurosci 2018 Dec 6. Epub 2018 Dec 6.

Helen Wills Neuroscience Institute, University of California, Berkeley, USA; Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA, USA.

The aggregation of fibrils of hyperphosphorylated and C-terminally truncated microtubule-associated tau protein characterizes 80% of all dementia disorders, the most common neurodegenerative disorders. These so-called tauopathies are hitherto not curable and their diagnosis, especially at early disease stages, has traditionally proven difficult. A keystone in the diagnosis of tauopathies was the development of methods to assess levels of tau protein in vivo in cerebrospinal fluid, which has significantly improved our knowledge about these conditions. Read More

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December 2018

Nutrient biomarker patterns, cognitive function, and fMRI measures of network efficiency in the aging brain.

Neuroimage 2018 Dec 7. Epub 2018 Dec 7.

Decision Neuroscience Laboratory, University of Illinois, Urbana, IL, USA; Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana, IL, USA; Carl R. Woese Institute for Genomic Biology, University of Illinois, Champaign, IL, USA; Center for Brain Plasticity, University of Illinois, Urbana, IL, USA; Department of Psychology, University of Illinois, Urbana, IL, USA; Department of Bioengineering, University of Illinois, Champaign, IL, USA; Division of Nutritional Sciences, University of Illinois, Champaign, IL, USA; Neuroscience Program, University of Illinois, Champaign, IL, USA. Electronic address:

A central aim of research in the psychological and brain sciences is to establish therapeutic interventions to promote healthy brain aging. Accumulating evidence indicates that diet and the many bioactive substances present in food are reasonable interventions to examine for dementia prevention. However, interdisciplinary research that applies methods from nutritional epidemiology and network neuroscience to investigate the role of nutrition in shaping functional brain network efficiency remains to be conducted. Read More

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December 2018