13,722 results match your criteria Dementia Vascular


Retinal microvasculature and cerebral small vessel disease in the Lothian Birth Cohort 1936 and Mild Stroke Study.

Sci Rep 2019 Apr 19;9(1):6320. Epub 2019 Apr 19.

Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK.

Research has suggested that the retinal vasculature may act as a surrogate marker for diseased cerebral vessels. Retinal vascular parameters were measured using Vessel Assessment and Measurement Platform for Images of the Retina (VAMPIRE) software in two cohorts: (i) community-dwelling older subjects of the Lothian Birth Cohort 1936 (n = 603); and (ii) patients with recent minor ischaemic stroke of the Mild Stroke Study (n = 155). Imaging markers of small vessel disease (SVD) (white matter hyperintensities [WMH] on structural MRI, visual scores and volume; perivascular spaces; lacunes and microbleeds), and vascular risk measures were assessed in both cohorts. Read More

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http://dx.doi.org/10.1038/s41598-019-42534-xDOI Listing

Chronic cerebral hypoperfusion-induced memory impairment and hippocampal long-term potentiation deficits are improved by cholinergic stimulation in rats.

Pharmacol Rep 2019 Jan 30;71(3):443-448. Epub 2019 Jan 30.

Centre for Drug Research, Universiti Sains Malaysia, Penang, Malaysia. Electronic address:

Background: Chronic cerebral hypoperfusion (CCH) can induce the accumulation of reactive oxygen species, which leads to oxidative damage, neuronal injury, and central cholinergic dysfunction in vulnerable regions of the brain, such as the hippocampus and cerebral cortex. These effects can lead to significant cognitive impairments in clinical populations of vascular dementia (VaD). The present studies aimed to investigate the role of the cholinergic system in memory functions and hippocampal long-term potentiation (LTP) impairments induced by CCH in rats. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.012DOI Listing
January 2019

Neuroprotective Effects of Zafirlukast, Piracetam and Their Combination on L-Methionine-Induced Vascular Dementia in Rats.

Fundam Clin Pharmacol 2019 Apr 18. Epub 2019 Apr 18.

Pharmacology Department, October University for Modern Science and Arts, 11787, 6, October City, Egypt.

Vascular dementia is considered a vascular cognitive impairment disease caused by neuronal degeneration in the brain. Several studies have supported the hypothesis that oxidative stress and endothelial dysfunction are the main pathogenic factors in vascular dementia. This current study aims to determine the possible neuroprotective effects of zafirlukast, piracetam and the combination of piracetam and zafirlukast on L-methionine-induced vascular dementia in rats. Read More

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http://dx.doi.org/10.1111/fcp.12473DOI Listing

Protective cardiac conditioning by an atypical cytokine.

Clin Sci (Lond) 2019 Apr 18;133(8):933-937. Epub 2019 Apr 18.

Chair of Vascular Biology, Institute for Stroke and Dementia Research (ISD), Klinikum der Universität München (KUM), Ludwig-Maximilians-University (LMU), Munich 81377, Germany

Ischemic heart disease (IHD) represents the leading cause of morbidity and mortality worldwide. Therapy options generally aim at restoring the blood flow to the heart muscle and relieve the ischemic insult. Paradoxically, coronary artery reperfusion itself, both during emergency intervention in ST segment elevation myocardial infarction (STEMI) patients or in the setting of elective cardiac surgery, damages the heart muscle, a phenomenon known as myocardial ischemia-reperfusion (I/R) injury (IRI). Read More

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http://www.clinsci.org/lookup/doi/10.1042/CS20190036
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http://dx.doi.org/10.1042/CS20190036DOI Listing
April 2019
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Intravenous Infusion of Mesenchymal Stem Cells Improves Impaired Cognitive Function in a Cerebral Small Vessel Disease Model.

Neuroscience 2019 Apr 15. Epub 2019 Apr 15.

Department of Neural Regenerative Medicine, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Sapporo, 060-8556, Japan; Department of Neurology, Yale University School of Medicine, New Haven, CT, 06510, USA; Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, CT, 06516, USA.

Cerebral small vessel disease (CSVD) is not only a cause of vascular dementia (VD) but also a contributing factor to Alzheimer's disease (AD). The essential pathological feature of CSVD is the disruption of blood-brain barrier (BBB). Dysfunction of BBB due to degeneration of both endothelial cells and pericytes in capillaries leads to neuronal damage and progressive brain atrophy. Read More

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http://dx.doi.org/10.1016/j.neuroscience.2019.04.018DOI Listing

Behavioural and Psychological Symptoms in Neurocognitive Disorders: Specific Patterns in Dementia Subtypes.

Open Med (Wars) 2019 4;14:307-316. Epub 2019 Apr 4.

Department of Neurology, Faculty of Medicine, University of Debrecen, Debrecen, Egyetem tér 1, H-4032, Hungary.

Background: Behavioural and psychological symptoms in dementia (BPSD) form an important sub-syndrome of dementia. We assessed the frequency and severity of BPSD in a random sample of Hungarian treatment-naïve dementia patients. Furthermore, we examined the relationship between cognitive symptoms and BPSD and the pattern of BPSD in specific types of dementias. Read More

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http://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019
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http://dx.doi.org/10.1515/med-2019-0028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463819PMC
April 2019
1 Read

Prognostic value of "tissue-based" definitions of TIA and minor stroke: Population-based study.

Neurology 2019 Apr 17. Epub 2019 Apr 17.

From the Centre for the Prevention of Stroke and Dementia, Nuffield Department of Clinical Neurosciences, University of Oxford, UK.

Objective: Since use of diffusion-weighted imaging (DWI) positivity in the "tissue-based" definition of stroke in patients with a clinical TIA is supported by the high associated 90-day risk of recurrent stroke, we aimed to determine long-term prognostic significance, stratified by etiologic subtype, and whether the same tissue-based distinction is predictive in minor strokes.

Methods: Consecutive eligible patients with TIA or minor stroke (NIH Stroke Scale [NIHSS] ≤3) in the population-based Oxford Vascular Study underwent brain MRI at baseline. Stroke risk on 10-year follow-up was stratified by NIHSS (0/1 vs 2/3) and Trial of Org 10172 in Acute Stroke Treatment classification of the initial event. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007531DOI Listing

Peri-Infarct Upregulation of the Oxytocin Receptor in Vascular Dementia.

J Neuropathol Exp Neurol 2019 May;78(5):436-452

Department of Translational Science and Molecular Medicine, Michigan State University, Grand Rapids, Michigan.

Vascular dementia (VaD) is cognitive decline linked to reduced cerebral blood perfusion, yet there are few therapeutic options to protect cognitive function following cerebrovascular accidents. The purpose of this study was to profile gene expression changes unique to VaD to identify and characterize disease relevant changes that could offer clues for future therapeutic direction. Microarray-based profiling and validation studies of postmortem frontal cortex samples from VaD, Alzheimer disease, and age-matched control subjects revealed that the oxytocin receptor (OXTR) was strongly and differentially upregulated in VaD. Read More

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http://dx.doi.org/10.1093/jnen/nlz023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467199PMC
May 2019
1 Read

[Fangji Dihuang Decoction formula syndrome and Fengyin Decoction formula syndrome:application in stroke and mental disorders].

Authors:
Xing-Jiang Xiong

Zhongguo Zhong Yao Za Zhi 2019 Feb;44(3):602-607

Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China.

Fangji Dihuang Decoction and Fengyin Decoction, which were firstly recorded in Synopsis of the Golden Chamber, could be used to treat stroke. However, both of these two decoctions are used infrequently. There is a clear pathogenesis of modern pathophysiology behind Fangji Dihuang Decoction syndrome and Fengyin Decoction syndrome, which can be interpreted by modern language of science. Read More

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http://dx.doi.org/10.19540/j.cnki.cjcmm.20181128.004DOI Listing
February 2019
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[Diabetes Mellitus and Dementia].

Authors:
Hiroyuki Umegaki

Brain Nerve 2019 Apr;71(4):409-414

Community Healthcare and Geriatrics, Medicine in Growth and Aging, Nagoya University Graduate School of Medicine.

Accumulating data have established that diabetes mellitus (DM) is a risk factor for dementia of both Alzheimer's and vascular types. However, the underlying mechanism of DM-induced neurodegeneration remains to be fully elucidated. Insulin resistance (IR) in the brain may be involved in DM-related cognitive impairment or dementia, and treatment of IR in the brain may lead to the prevention and/or treatment of dementia. Read More

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http://dx.doi.org/10.11477/mf.1416201286DOI Listing
April 2019
2 Reads

Dl-3-n-butylphthalide promotes remyelination process in cerebral white matter in rats subjected to ischemic stroke.

Brain Res 2019 Apr 12. Epub 2019 Apr 12.

Department of Neurology, The first affiliated hospital, China Medical University, Shenyang, Liaoning, PR China.

Remyelination has been widely noticed as an important repair mechanism triggered after a stroke-induced white matter injury, but it often fails due to the lack of recruitment of the oligodendrocyte progenitor cells (OPCs) to the demyelinated area and the inadequate differentiation of OPCs. Racemic dl-3-n-butylphthalide (dl-NBP) has been reported to improve the functional recovery in animal models of vascular dementia, Alzheimer's disease (AD) and ischemic stroke. Dl-NBP (70 mg/kg) by oral gavage for two weeks from day 7 after a stroke was administered in the study, the treatment promoted differentiation and maturation of OPCs in perilesional white matter and enhanced the length of crossing corticospinal tract (CST) fibers into the denervated hemispheres. Read More

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http://dx.doi.org/10.1016/j.brainres.2019.03.017DOI Listing
April 2019
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Susceptibility Weighted Imaging (SWI) Recommended as a Regular Magnetic Resonance Diagnosis for Vascular Dementia to Identify Independent Idiopathic Normal Pressure Hydrocephalus Before Ventriculo-Peritoneal (V-P) Shunt Treatment: A Case Study.

Front Neurol 2019 29;10:262. Epub 2019 Mar 29.

Translational Medicine Research Center, School of Pharmaceutical Sciences, Xiamen University, Xiamen, China.

Idiopathic normal pressure hydrocephalus (INPH) with comorbid vascular dementia (VD) often have poor response to ventriculo-peritoneal (V-P) shunt. Here, three patients over the age of 60 came to the hospital with the similar clinical symptoms, Evan index over 0.3, mini-mental state examination (MMSE) score <27, and cerebrospinal fluid (CSF) pressure under 200 mmHO. Read More

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http://dx.doi.org/10.3389/fneur.2019.00262DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6449466PMC
March 2019
1 Read

Breath Qigong Improves Recognition in Seniors With Vascular Cognitive Impairment.

Altern Ther Health Med 2019 Jan;25(1):20-26

Context: Vascular cognitive impairment (VCI) or vascular dementia is widely considered to be the second-most-common cause of dementia after Alzheimer's disease, accounting for 20% of cases. Little is known about the effectiveness of breath qigong for seniors suffering from VCI or dementia.

Objectives: For seniors with VCI, the study aimed to compare the benefits of qigong practice, cognitive training, and qigong practice + cognitive training in improving cognitive function, memory, executive function, and daily problem-solving ability. Read More

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January 2019

A mouse model to investigate the effects of lifestyle on vascular dementia and Alzheimer's disease?

Authors:

Brain Behav Immun 2019 Apr 10. Epub 2019 Apr 10.

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http://dx.doi.org/10.1016/j.bbi.2019.04.020DOI Listing
April 2019
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Stroke genetics: discovery, biology, and clinical applications.

Lancet Neurol 2019 Apr 8. Epub 2019 Apr 8.

Program in Medical Population and Genetics, Broad Institute, Cambridge, MA, USA; Henry and Allison McCance Center for Brain Health, and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.

Stroke, a leading cause of long-term disability and death worldwide, has a heritable component. Recent gene discovery efforts have expanded the number of known single-gene disorders associated with stroke and have linked common variants at approximately 35 genetic loci to stroke risk. These discoveries have highlighted novel mechanisms and pathways implicated in stroke related to large artery atherosclerosis, cardioembolism, and small vessel disease, and defined shared genetic influences with related vascular traits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S14744422193004
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http://dx.doi.org/10.1016/S1474-4422(19)30043-2DOI Listing
April 2019
4 Reads

Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.

Front Neurol 2019 26;10:238. Epub 2019 Mar 26.

Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

White matter hyperintensities of presumed vascular origin (WMH) are a common finding in elderly people and a growing social malady in the aging western societies. As a manifestation of cerebral small vessel disease, WMH are considered to be a vascular contributor to various sequelae such as cognitive decline, dementia, depression, stroke as well as gait and balance problems. While pathophysiology and therapeutical options remain unclear, large-scale studies have improved the understanding of WMH, particularly by quantitative assessment of WMH. Read More

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http://dx.doi.org/10.3389/fneur.2019.00238DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443932PMC
March 2019
10 Reads

Continuation versus discontinuation of treatment for severe dementia: randomized, pragmatic, open-label, clinical trial to evaluate the efficacy of continuing drug treatment in patients with severe dementia (STOP-DEM).

BMC Geriatr 2019 Apr 11;19(1):101. Epub 2019 Apr 11.

Primary Care Research Unit of Mallorca, Baleares Health Services-IbSalut, Palma, Spain.

Background: Previous observational studies and clinical trials have shown that cholinesterase inhibitors (with or without memantine) provide benefit for patients with mild-to-moderate Alzheimer's disease. However, the impact of treatment continuation after progression to severe disease is unknown. The main aim of this study is to evaluate the effect and safety of continuing treatment with ChEIs (with or without memantine) for patients with severe dementia. Read More

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http://dx.doi.org/10.1186/s12877-019-1122-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458648PMC
April 2019
1 Read

Risk of dementia in patients with end-stage renal disease under maintenance dialysis-a nationwide population-based study with consideration of competing risk of mortality.

Alzheimers Res Ther 2019 Apr 9;11(1):31. Epub 2019 Apr 9.

Department of Internal Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Background: Dementia is prevalent in the end-stage renal disease (ESRD) population. However, it is still not clarified whether ESRD is one of the etiology of dementia or its attributable effect on the cumulative risk of dementia. Meanwhile, the effect of competing risk of mortality should be taken into consideration when performing epidemiologic analyses among populations with high risk of mortality. Read More

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http://dx.doi.org/10.1186/s13195-019-0486-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456981PMC
April 2019
2 Reads

Effects of α-lipoic acid on chronic cerebrovascular hypoperfusion in an animal model of vascular dementia.

Eur Rev Med Pharmacol Sci 2019 Mar;23(6):2587-2595

Brain Research Institute, Wonkwang University School of Medicine, Iksan, Jeonbuk, Korea.

Objective: Given the aging population, the treatment of vascular dementia (VaD) is becoming increasingly important. The antioxidant α-lipoic acid (α-LA) protects against neurodegeneration in VaD, but the underlying mechanisms remain unclear. Hence, we aimed to identify the effects of α-LA on cognitive function following chronic cerebrovascular hypoperfusion in a VaD animal model. Read More

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http://www.europeanreview.org/article/17408
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http://dx.doi.org/10.26355/eurrev_201903_17408DOI Listing
March 2019
8 Reads

Diabetes Mellitus-Related Fractional Glucose Uptake in Men and Women Imaged With F-FDG PET-CT.

J Endocr Soc 2019 Apr 27;3(4):773-783. Epub 2019 Feb 27.

Department of Internal Medicine and Endocrinology, Reinier the Graaf Hospital, Delft, Netherlands.

Context: Cohort studies show that cognitive dysfunction and both vascular and Alzheimer's dementia are more common in patients with type 2 diabetes mellitus (T2DM).

Objective: To review and compare brain volume and F-fluorodeoxyglucose (FDG) uptake in brain of individuals age 60 to 70 years with or without type 2 diabetes.

Design: We searched 620 medical records for negative FDG PET-CT scans obtained during 33 months. Read More

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http://dx.doi.org/10.1210/js.2019-00001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446889PMC
April 2019
2 Reads

Biomarker Matrix to Track Short Term Disease Progression in Amnestic Mild Cognitive Impairment Patients with Prodromal Alzheimer's Disease.

J Alzheimers Dis 2019 Apr 1. Epub 2019 Apr 1.

Laboratory of Neuroimaging and Alzheimer's Epidemiology, IRCCS Istituto Centro San Giovanni di Dio Fatebenefratelli, Brescia, Italy.

Background: Assessment of human brain atrophy in temporal regions using magnetic resonance imaging (MRI), resting state functional MRI connectivity in the left parietal cortex, and limbic electroencephalographic (rsEEG) rhythms as well as plasma amyloid peptide 42 (Aβ42) has shown that each is a promising biomarker of disease progression in amnestic mild cognitive impairment (aMCI) patients with prodromal Alzheimer's disease (AD). However, the value of their combined use is unknown.

Objective: To evaluate the association with cognitive decline and the effect on sample size calculation when using a biomarker composite matrix in prodromal AD clinical trials. Read More

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http://dx.doi.org/10.3233/JAD-181016DOI Listing
April 2019
5 Reads

A cortical microvascular structure in vascular dementia, Alzheimer's disease, frontotemporal lobar degeneration, and non-demented controls: a sign of angiogenesis due to brain ischaemia?

Neuropathol Appl Neurobiol 2019 Apr 8. Epub 2019 Apr 8.

Department of Clinical Sciences Lund, Division of Oncology and Pathology, Lund University, Sweden.

Aims: We observed a microvascular structure in the cerebral cortex that has not, to our knowledge, been previously described. We have termed the structure a 'raspberry', referring to its appearance under a bright-field microscope. We hypothesised that raspberries form through angiogenesis due to some form of brain ischaemia or hypoperfusion. Read More

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http://dx.doi.org/10.1111/nan.12552DOI Listing
April 2019
1 Read

Mutation and association analyses of dementia-causal genes in Han Chinese patients with early-onset and familial Alzheimer's disease.

J Psychiatr Res 2019 Mar 30;113:141-147. Epub 2019 Mar 30.

Center for Neurodegenerative Diseases, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China; China National Clinical Research Center for Neurological Diseases, Beijing, 100050, China; Parkinson's Disease Center, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, 100050, China. Electronic address:

Alzheimer's disease (AD) is the most common cause of dementia in the elderly. It shares clinical and pathological features with other types of dementia, such as vascular dementia (VaD), Lewy body dementia (LBD), and frontotemporal dementia (FTD). We have hypothesized that there might be an overlapping molecular mechanism and genetic basis to the different types of dementia. Read More

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http://dx.doi.org/10.1016/j.jpsychires.2019.03.026DOI Listing

Chronic cerebral hypoperfusion upregulates leptin receptor expression in astrocytes and tau phosphorylation in tau transgenic mice.

Neurosci Lett 2019 Apr 4;704:133-140. Epub 2019 Apr 4.

Department of Neurology, Mie University Graduate School of Medicine, Tsu, Mie, Japan.

Alzheimer's disease (AD) is the most common type of dementia in aging adults. Increasing evidence has revealed that vascular risk factors influence the midlife development of AD and that diet-induced obesity accelerates tau phosphorylation in tau transgenic mice and increases the level of serum leptin receptor (leptin-R). Leptin-R is upregulated in the peri-infarct cortices after acute cerebral ischemia. Read More

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http://dx.doi.org/10.1016/j.neulet.2019.04.009DOI Listing
April 2019
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Plasma amyloid beta levels and platelet mitochondrial respiration in patients with Alzheimer's disease.

Clin Biochem 2019 Apr 4. Epub 2019 Apr 4.

Department of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital in Prague, Czech Republic. Electronic address:

Objectives: Altered amyloid metabolism and mitochondrial dysfunction play key roles in the development of Alzheimer's disease (AD). We asked whether an association exists between disturbed platelet mitochondrial respiration and the plasma concentrations of Aβ and Aβ in patients with AD.

Design And Methods: Plasma Aβ and Aβ concentrations and mitochondrial respiration in intact and permeabilized platelets were measured in 50 patients with AD, 15 patients with vascular dementia and 25 control subjects. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2019.04.003DOI Listing

Cerebral white matter free water: A sensitive biomarker of cognition and function.

Neurology 2019 Apr 5. Epub 2019 Apr 5.

From the Imaging of Dementia and Aging Laboratory and Center for Neurosciences (P.M., E.F., B.S., O.M., C.D.), Davis, CA; and Department of Neurology (D.K.J., J.M.O., S.T.F., C.D.), University of California, Davis.

Objective: To determine whether free water (FW) content, initially developed to correct metrics derived from diffusion tensor imaging and recently found to be strongly associated with vascular risk factors, may constitute a sensitive biomarker of white matter (WM) microstructural differences associated with cognitive performance but remains unknown.

Methods: Five hundred thirty-six cognitively diverse individuals, aged 77 ± 8 years, received yearly comprehensive clinical evaluations and a baseline MRI examination of whom 224 underwent follow-up MRI. WM microstructural measures, including FW, fractional anisotropy, and mean diffusivity corrected for FW and WM hyperintensity burden were computed within WM voxels of each individual. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007449DOI Listing
April 2019
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Altered static and dynamic functional network connectivity in Alzheimer's disease and subcortical ischemic vascular disease: shared and specific brain connectivity abnormalities.

Hum Brain Mapp 2019 Apr 5. Epub 2019 Apr 5.

The Mind Research Network, Albuquerque, New Mexico.

Subcortical ischemic vascular disease (SIVD) is a major subtype of vascular dementia with features that overlap clinically with Alzheimer's disease (AD), confounding diagnosis. Neuroimaging is a more specific and biologically based approach for detecting brain changes and thus may help to distinguish these diseases. There is still a lack of knowledge regarding the shared and specific functional brain abnormalities, especially functional connectivity changes in relation to AD and SIVD. Read More

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http://dx.doi.org/10.1002/hbm.24591DOI Listing
April 2019
2 Reads

Sex as a biological variable in the pathology and pharmacology of neurodegenerative and neurovascular diseases.

Br J Pharmacol 2019 Apr 4. Epub 2019 Apr 4.

University of Texas McGovern Medical School, Department of Neurology, Fannin Street, Houston, TX, 77030.

The incidence of dementia, most commonly caused by cerebrovascular and neurodegenerative diseases, continues to grow as our population ages. Alzheimer disease (AD) and vascular cognitive impairment (VCI) are responsible for more than 80% of all cases of dementia. There are few effective, long-term treatments for AD and VCI-related conditions (e. Read More

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http://dx.doi.org/10.1111/bph.14675DOI Listing
April 2019
1 Read

EEG Analysis and Spect Imaging in Alzheimer's Disease, Vascular Dementia and Mild Cognitive Impairment.

Psychiatr Danub 2019 Mar;31(1):111-115

Department of Neurology, University Hospital Center Zagreb, Kišpatićeva 12, 10000 Zagreb, Croatia,

Background: Alzheimer's disease (AD) and vascular dementia (VaD) represent a leading public-health problem given the rising age of the population. Early diagnosis of dementia, especially at the stage of mild cognitive impairment (MCI) has become an important goal of the modern patient work-up. Brain perfusion single-photon emission computed tomography (SPECT) has become a mainstay of diagnostic algorithms in patients with dementia showing specific patterns of hypoperfusion in temporal and parietal lobes. Read More

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http://dx.doi.org/10.24869/psyd.2019.111DOI Listing
March 2019
1 Read

Carotid Artery Disease in Post-Stroke Survivors and Effects of Enriched Environment on Stroke Pathology in a Mouse Model of Carotid Artery Stenosis.

Neuropathol Appl Neurobiol 2019 Apr 4. Epub 2019 Apr 4.

Neurovascular Research Group, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, United Kingdom.

Aims: Carotid artery disease (CAD) is an important risk factor for stroke. We first evaluated CAD and stroke pathology in elderly post-stroke survivors. To simulate CAD, we assessed long-term consequences of bilateral common carotid artery stenosis (BCAS) in mice and exposed them to environmental enrichment (EE). Read More

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http://dx.doi.org/10.1111/nan.12550DOI Listing
April 2019
2 Reads

[Professor 's experience in the treatment of vascular dementia with acupuncture and moxibustion].

Zhongguo Zhen Jiu 2019 Mar;39(3):299-302

School of Acupuncture, Moxibustion and Tuina, Anhui University of CM, Hefei 230038, China.

In the aspects of the acupoint prescription, acupuncture techniques and typical cases, the characteristics and experience of professor in the clinical treatment of vascular dementia with acupuncture and moxibustion were introduced. Vascular dementia is treated on the base of etiology, focusing on the brain as the root cause, with the reinforcing and the promoting as the dominant principle of acupuncture. The treatment is emphasized on tonifying the kidney to fill up marrow, strengthening the spleen to nourish the brain and promoting the collateral circulation to improve the intelligence. Read More

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http://dx.doi.org/10.13703/j.0255-2930.2019.03.019DOI Listing
March 2019
2 Reads

Jia-Wei-Kai-Xin-San, an Herbal Medicine Formula, Ameliorates Cognitive Deficits via Modulating Metabolism of Beta Amyloid Protein and Neurotrophic Factors in Hippocampus of Aβ Induced Cognitive Deficit Mice.

Front Pharmacol 2019 19;10:258. Epub 2019 Mar 19.

Jiangsu Key Laboratory for High Technology Research of TCM Formulae and Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine, Nanjing, China.

Jia-Wei-Kai-Xin-San (JWKXS) is a Chinese medicine formula applied for treating morbid forgetfulness in ancient China. Today, this formula is frequently applied for Alzheimer's disease and vascular dementia (VD) in clinic. Here, we developed it as granules and aimed to evaluate its anti-AD effect on β amyloid protein 1-42 (Aβ) induced cognitive deficit mice and reveal the possible molecular mechanisms. Read More

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http://dx.doi.org/10.3389/fphar.2019.00258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433786PMC
March 2019
4 Reads

Parafoveal vessel loss and correlation between peripapillary vessel density and cognitive performance in amnestic mild cognitive impairment and early Alzheimer's Disease on optical coherence tomography angiography.

PLoS One 2019 2;14(4):e0214685. Epub 2019 Apr 2.

Department of Ophthalmology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States of America.

Purpose: Patients with Alzheimer's Disease (AD) exhibit decreased retinal blood flow and vessel density (VD). However, it is not known whether these changes are also present in individuals with early AD (eAD) or amnestic type mild cognitive impairment (aMCI), an enriched pre-AD population with a higher risk for progressing to dementia. We performed a prospective case-control clinical study to investigate whether optical coherence tomography angiography (OCTA) parameters in the macula and disc are altered in those with aMCI and eAD. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0214685PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445433PMC
April 2019
10 Reads
3.234 Impact Factor

Randomized Trial of Marine n-3 Polyunsaturated Fatty Acids for the Prevention of Cerebral Small Vessel Disease and Inflammation in Aging (PUFA Trial): Rationale, Design and Baseline Results.

Nutrients 2019 Mar 29;11(4). Epub 2019 Mar 29.

Department of Neurology, Oregon Health and Science University, Portland, OR 97219, USA.

Vascular risk factors for age-related cognitive decline are significant, and their management may ultimately prove the most successful strategy for reducing risk and sustaining cognitive health. This randomized, double-blinded, placebo-controlled trial with parallel group allocation to either marine n-3 polyunsaturated fatty acids (n-3 PUFA) or soybean oil placebo assesses the effects on the total volume of accumulation in cerebral white matter hyperintensities (WMH), a potentially modifiable neurovascular component of age-related cognitive decline. Total WMH accumulation over 3 years is the primary endpoint. Read More

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http://dx.doi.org/10.3390/nu11040735DOI Listing
March 2019
4 Reads

[Research in Motor Neuron Diseases Caused by Natural Substances: Focus on Pathological Mechanisms of Neurolathyrism].

Yakugaku Zasshi 2019 ;139(4):609-615

Laboratory of Biochemistry, School of Pharmacy, Nihon University.

Diseases of the motor-conducting system that cause moving disability affect socio-economic activity as well as human dignity. Neurolathyrism, konzo, and amyotrophic lateral sclerosis-parkinsonism-dementia complex (ALS-PDC) have attracted researchers to study the pathology of motor neuron (MN) diseases such as ALS. I have been studying neurolathyrism, which is caused by overconsumption of a legume grass pea (Lathyrys sativus L. Read More

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http://dx.doi.org/10.1248/yakushi.18-00202DOI Listing
April 2019
1 Read

Relevance of brain lesion location for cognition in vascular mild cognitive impairment.

Neuroimage Clin 2019 Mar 23;22:101789. Epub 2019 Mar 23.

Department of Medicine, Surgery and Neuroscience, University of Siena, Siena, Italy. Electronic address:

Background: Vascular mild cognitive impairment (VMCI) is a potentially transitional state between normal aging and vascular dementia. The presence of macroscopic white matter lesions (WML) of moderate or severe extension on brain MRI is the hallmark of the VMCI.

Objective: To assess the clinical relevance of the frequency of WML in patients with VMCI independently of total lesion volume (LV). Read More

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http://dx.doi.org/10.1016/j.nicl.2019.101789DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6439281PMC
March 2019
2 Reads

The VASCOG criteria for vascular cognitive disorders: a validation study.

Eur J Neurol 2019 Mar 30. Epub 2019 Mar 30.

Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, University of New South Wales, Sydney, Australia.

Background: VASCOG criteria for vascular cognitive disorders were published in 2014, but their concurrent and predictive validity have not been examined.

Methods: Participants (N=165, aged 49-86 years) were from Sydney Stroke Study, a longitudinal study of post-stroke cognitive impairment and dementia. Diagnoses using NINDS-AIREN, ADDTC, and DSM-IV criteria for vascular dementia (VaD) were made by consensus at multi-disciplinary case conferences. Read More

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http://dx.doi.org/10.1111/ene.13960DOI Listing
March 2019
2 Reads

Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.

Authors:
Amy R Bentley Yun J Sung Michael R Brown Thomas W Winkler Aldi T Kraja Ioanna Ntalla Karen Schwander Daniel I Chasman Elise Lim Xuan Deng Xiuqing Guo Jingmin Liu Yingchang Lu Ching-Yu Cheng Xueling Sim Dina Vojinovic Jennifer E Huffman Solomon K Musani Changwei Li Mary F Feitosa Melissa A Richard Raymond Noordam Jenna Baker Guanjie Chen Hugues Aschard Traci M Bartz Jingzhong Ding Rajkumar Dorajoo Alisa K Manning Tuomo Rankinen Albert V Smith Salman M Tajuddin Wei Zhao Mariaelisa Graff Maris Alver Mathilde Boissel Jin Fang Chai Xu Chen Jasmin Divers Evangelos Evangelou Chuan Gao Anuj Goel Yanick Hagemeijer Sarah E Harris Fernando P Hartwig Meian He Andrea R V R Horimoto Fang-Chi Hsu Yi-Jen Hung Anne U Jackson Anuradhani Kasturiratne Pirjo Komulainen Brigitte Kühnel Karin Leander Keng-Hung Lin Jian'an Luan Leo-Pekka Lyytikäinen Nana Matoba Ilja M Nolte Maik Pietzner Bram Prins Muhammad Riaz Antonietta Robino M Abdullah Said Nicole Schupf Robert A Scott Tamar Sofer Alena Stancáková Fumihiko Takeuchi Bamidele O Tayo Peter J van der Most Tibor V Varga Tzung-Dau Wang Yajuan Wang Erin B Ware Wanqing Wen Yong-Bing Xiang Lisa R Yanek Weihua Zhang Jing Hua Zhao Adebowale Adeyemo Saima Afaq Najaf Amin Marzyeh Amini Dan E Arking Zorayr Arzumanyan Tin Aung Christie Ballantyne R Graham Barr Lawrence F Bielak Eric Boerwinkle Erwin P Bottinger Ulrich Broeckel Morris Brown Brian E Cade Archie Campbell Mickaël Canouil Sabanayagam Charumathi Yii-Der Ida Chen Kaare Christensen Maria Pina Concas John M Connell Lisa de Las Fuentes H Janaka de Silva Paul S de Vries Ayo Doumatey Qing Duan Charles B Eaton Ruben N Eppinga Jessica D Faul James S Floyd Nita G Forouhi Terrence Forrester Yechiel Friedlander Ilaria Gandin He Gao Mohsen Ghanbari Sina A Gharib Bruna Gigante Franco Giulianini Hans J Grabe C Charles Gu Tamara B Harris Sami Heikkinen Chew-Kiat Heng Makoto Hirata James E Hixson M Arfan Ikram Yucheng Jia Roby Joehanes Craig Johnson Jost Bruno Jonas Anne E Justice Tomohiro Katsuya Chiea Chuen Khor Tuomas O Kilpeläinen Woon-Puay Koh Ivana Kolcic Charles Kooperberg Jose E Krieger Stephen B Kritchevsky Michiaki Kubo Johanna Kuusisto Timo A Lakka Carl D Langefeld Claudia Langenberg Lenore J Launer Benjamin Lehne Cora E Lewis Yize Li Jingjing Liang Shiow Lin Ching-Ti Liu Jianjun Liu Kiang Liu Marie Loh Kurt K Lohman Tin Louie Anna Luzzi Reedik Mägi Anubha Mahajan Ani W Manichaikul Colin A McKenzie Thomas Meitinger Andres Metspalu Yuri Milaneschi Lili Milani Karen L Mohlke Yukihide Momozawa Andrew P Morris Alison D Murray Mike A Nalls Matthias Nauck Christopher P Nelson Kari E North Jeffrey R O'Connell Nicholette D Palmer George J Papanicolau Nancy L Pedersen Annette Peters Patricia A Peyser Ozren Polasek Neil Poulter Olli T Raitakari Alex P Reiner Frida Renström Treva K Rice Stephen S Rich Jennifer G Robinson Lynda M Rose Frits R Rosendaal Igor Rudan Carsten O Schmidt Pamela J Schreiner William R Scott Peter Sever Yuan Shi Stephen Sidney Mario Sims Jennifer A Smith Harold Snieder John M Starr Konstantin Strauch Heather M Stringham Nicholas Y Q Tan Hua Tang Kent D Taylor Yik Ying Teo Yih Chung Tham Henning Tiemeier Stephen T Turner André G Uitterlinden Diana van Heemst Melanie Waldenberger Heming Wang Lan Wang Lihua Wang Wen Bin Wei Christine A Williams Gregory Wilson Mary K Wojczynski Jie Yao Kristin Young Caizheng Yu Jian-Min Yuan Jie Zhou Alan B Zonderman Diane M Becker Michael Boehnke Donald W Bowden John C Chambers Richard S Cooper Ulf de Faire Ian J Deary Paul Elliott Tõnu Esko Martin Farrall Paul W Franks Barry I Freedman Philippe Froguel Paolo Gasparini Christian Gieger Bernardo L Horta Jyh-Ming Jimmy Juang Yoichiro Kamatani Candace M Kammerer Norihiro Kato Jaspal S Kooner Markku Laakso Cathy C Laurie I-Te Lee Terho Lehtimäki Patrik K E Magnusson Albertine J Oldehinkel Brenda W J H Penninx Alexandre C Pereira Rainer Rauramaa Susan Redline Nilesh J Samani James Scott Xiao-Ou Shu Pim van der Harst Lynne E Wagenknecht Jun-Sing Wang Ya Xing Wang Nicholas J Wareham Hugh Watkins David R Weir Ananda R Wickremasinghe Tangchun Wu Eleftheria Zeggini Wei Zheng Claude Bouchard Michele K Evans Vilmundur Gudnason Sharon L R Kardia Yongmei Liu Bruce M Psaty Paul M Ridker Rob M van Dam Dennis O Mook-Kanamori Myriam Fornage Michael A Province Tanika N Kelly Ervin R Fox Caroline Hayward Cornelia M van Duijn E Shyong Tai Tien Yin Wong Ruth J F Loos Nora Franceschini Jerome I Rotter Xiaofeng Zhu Laura J Bierut W James Gauderman Kenneth Rice Patricia B Munroe Alanna C Morrison Dabeeru C Rao Charles N Rotimi L Adrienne Cupples

Nat Genet 2019 04 29;51(4):636-648. Epub 2019 Mar 29.

Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.

The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Read More

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http://dx.doi.org/10.1038/s41588-019-0378-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6467258PMC
April 2019
8 Reads
29.352 Impact Factor

Vascular Cognitive Disorder.

Semin Neurol 2019 Apr 29;39(2):241-250. Epub 2019 Mar 29.

Centre for Healthy Brain Ageing, School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, NSW, Australia.

The term vascular cognitive disorder (VCD) refers to a heterogeneous group of disorders in which the primary feature is cognitive impairment attributable to cerebrovascular disease (CVD). This includes not only vascular dementia (VaD) but also cognitive impairment of insufficient severity to meet diagnostic criteria for dementia. VCD is recognized as the second most common cause of dementia after Alzheimer's disease (AD), but prevalence rates vary widely according to the diagnostic criteria employed. Read More

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http://dx.doi.org/10.1055/s-0039-1678582DOI Listing
April 2019
3 Reads

Alzheimer's Disease Including Focal Presentations.

Semin Neurol 2019 Apr 29;39(2):213-226. Epub 2019 Mar 29.

Department of Neurology, Institute of Memory and Alzheimer's Disease, Assistance Publique - Hopitaux de Paris, Pitié-Salpêtrière Hospital, Paris, France.

Alzheimer's disease (AD) is the commonest neurodegenerative disease and the most frequent cause of dementia. It affects 30 million people worldwide. Current research criteria focus on biomarkers' status for amyloid and tau using positron emission tomography and cerebrospinal fluid analysis, independent of clinical status. Read More

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http://dx.doi.org/10.1055/s-0039-1681041DOI Listing
April 2019
2 Reads

Neuroimaging in Dementias.

Semin Neurol 2019 Apr 29;39(2):188-199. Epub 2019 Mar 29.

Department of Radiology of Biomedical Imaging, Yale School of Medicine, New Haven, Connecticut.

Dementia is a global health issue, the burden of which will worsen with an increasingly aging population. Alzheimer's disease (AD) is the most common dementia, with 50 to 60% of all dementias attributable to AD alone, while the rest are mostly due to frontotemporal lobar dementia, dementia with Lewy bodies, Parkinson's disease dementia, and vascular dementia. Diagnosis of dementias is made clinically with the aid of other testing modalities including neuroimaging. Read More

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http://dx.doi.org/10.1055/s-0039-1678580DOI Listing
April 2019
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An Overview of Primary Dementias as Clinicopathological Entities.

Authors:
Arash Salardini

Semin Neurol 2019 Apr 29;39(2):153-166. Epub 2019 Mar 29.

Department of Neurology, Yale School of Medicine, New Haven, Connecticut.

Dementia is a state of cognitive dysfunction which leads to functional decline. It is a syndrome caused by several medical and neurological causes, but most cases of dementia are due to "primary dementias." Primary dementias are neurological diseases whose manifestations are predominantly cognitive. Read More

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http://dx.doi.org/10.1055/s-0039-1683445DOI Listing
April 2019
4 Reads

Neurovascular and Cognitive Dysfunction in Hypertension.

Circ Res 2019 Mar;124(7):1025-1044

Departments of Neurology (R.F.G.), Johns Hopkins University, Baltimore, MD.

Hypertension has emerged as a leading cause of age-related cognitive impairment. Long known to be associated with dementia caused by vascular factors, hypertension has more recently been linked also to Alzheimer disease-the major cause of dementia in older people. Thus, although midlife hypertension is a risk factor for late-life dementia, hypertension may also promote the neurodegenerative pathology underlying Alzheimer disease. Read More

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http://dx.doi.org/10.1161/CIRCRESAHA.118.313260DOI Listing
March 2019
1 Read

Incident Atrial Fibrillation, Dementia and the Role of Anticoagulation: A Population-Based Cohort Study.

Thromb Haemost 2019 Mar 27. Epub 2019 Mar 27.

Institute for Epidemiology, Statistics and Informatics GmbH, Frankfurt, Germany.

Introduction:  Atrial fibrillation (AF) is associated with dementia. Anticoagulation may modify this relationship, but it is unclear if this is due to stroke reduction alone.

Methods:  Age- and sex-matched individuals from the U. Read More

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http://dx.doi.org/10.1055/s-0039-1683429DOI Listing
March 2019
2 Reads

Metabolic Syndrome, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Longitudinal Studies.

Am J Geriatr Psychiatry 2019 Feb 15. Epub 2019 Feb 15.

Department of Biomedical and NeuroMotor Sciences, University of Bologna, Bologna, Italy.

Objective: A systematic review and a meta-analysis of both clinical and population-based studies was undertaken according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement to clarify whether Metabolic Syndrome (MetS) is a risk or a protective factor for incident dementia, Alzheimer disease (AD), and vascular dementia (VaD), and whether it's involved in progression to dementia in patients affected by mild cognitive impairment (MCI).

Methods: Search terms included ("metabolic syndrome" OR "syndrome x" OR "plurimetabolic syndrome") AND ("dementia" OR "Alzheimer disease" OR "vascular dementia" OR "mild cognitive impairment" OR "MCI"). Research was restricted to articles published in English between January 1, 2000 and August 31, 2018. Read More

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http://dx.doi.org/10.1016/j.jagp.2019.01.214DOI Listing
February 2019
1 Read

Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.

J Med Chem 2019 Apr 3. Epub 2019 Apr 3.

School of Pharmaceutical Sciences , Sun Yat-sen University , Guangzhou 510006 , P. R. China.

To identify phosphodiesterase-9 (PDE9) as a novel target for the treatment of vascular dementia (VaD), a series of pyrazolopyrimidinone analogues were discovered based on a hit 1. Hit-to-lead optimization resulted in a potent inhibitor 2 with excellent selectivity and physicochemical properties to enable in vivo studies. Oral administration of 2 (5. Read More

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http://dx.doi.org/10.1021/acs.jmedchem.8b01041DOI Listing
April 2019
2 Reads
5.447 Impact Factor

Survival and life-expectancy in a young-onset dementia cohort with six years of follow-up: the NeedYD-study.

Int Psychogeriatr 2019 Mar 27:1-9. Epub 2019 Mar 27.

Department of Primary and Community Care, Radboud University Medical Centre,Radboud Institute for Health Sciences,Nijmegen,the Netherlands.

ABSTRACTObjectives:The aim of this study was to investigate survival time and life-expectancy in people with young-onset dementia (YOD) and to examine the relationship with age, sex, dementia subtype and comorbidity.

Design, Setting And Participants: Survival was examined in 198 participants in the Needs in Young-onset Dementia study, including participants with Alzheimer's dementia (AD), vascular dementia (VaD) and frontotemporal dementia (FTD).

Measures: The primary outcomes were survival time after symptom onset and after date of diagnosis. Read More

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http://dx.doi.org/10.1017/S1041610219000152DOI Listing
March 2019
1 Read

Analysis of EEG Lemple-Ziv complexity and correlative aspects before and after treatment of anti-syphilis therapy for neurosyphilis.

Neurol Res 2019 Mar;41(3):199-203

a Department of Neurology , Beijing Ditan Hospital, Capital Medical University , Beijing , China.

Objective To investigate the diagnostic value of electroencephalogram (EEG) complexity in patients with neurosyphilis by comparing the changes of electroencephalogram Lempel-Ziv complexity (EEG-LZC) before and after anti-syphilis treatment. Methods The EEG complexity of neurosyphilis patients diagnosed in our hospital from July in 2015 to June in 2017 was analyzed and compared with other diagnostic results such as serology examination and cerebrospinal fluid examination. Results A total of 27 patients were diagnosed, including 19 males and 8 females, of which 6 were mesenchymal(cerebrospinal membrane and meningeal vascular), 16 were parenchymal(paralytic dementia, spinal cord tuberculosis and optic neuropathy), and 5 were asymptomatic. Read More

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http://dx.doi.org/10.1080/01616412.2018.1520438DOI Listing
March 2019
1 Read

Observational Study of Brain Atrophy and Cognitive Decline Comparing a Sample of Community-Dwelling People Taking Angiotensin Converting Enzyme Inhibitors and Angiotensin Receptor Blockers Over Time.

J Alzheimers Dis 2019 Mar 18. Epub 2019 Mar 18.

Department of Medicine, Peninsula Clinical School, Central Clinical School, Monash University, Melbourne, Australia.

Background: Hypertension is an established risk factor for dementia. However, it is unclear whether there are differential effects of angiotensin converting enzyme inhibitor (ACEi) or angiotensin receptor blockers (ARB) on brain health. In human observational studies, the evidence for superiority of either agent remains unclear. Read More

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http://dx.doi.org/10.3233/JAD-180943DOI Listing
March 2019
1 Read
4.151 Impact Factor