5,115 results match your criteria Dementia Due to HIV Disease


HIV and Alzheimer's disease: complex interactions of HIV-Tat with amyloid β peptide and Tau protein.

J Neurovirol 2019 Apr 23. Epub 2019 Apr 23.

Section of Infections of the Nervous System, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bldg 10; Room 7C-103, 10 Center Drive, Bethesda, MD, 20892, USA.

In patients infected with the human immunodeficiency virus (HIV), the HIV-Tat protein may be continually produced despite adequate antiretroviral therapy. As the HIV-infected population is aging, it is becoming increasingly important to understand how HIV-Tat may interact with proteins such as amyloid β and Tau which accumulate in the aging brain and eventually result in Alzheimer's disease. In this review, we examine the in vivo data from HIV-infected patients and animal models and the in vitro experiments that show how protein complexes between HIV-Tat and amyloid β occur through novel protein-protein interactions and how HIV-Tat may influence the pathways for amyloid β production, degradation, phagocytosis, and transport. Read More

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http://dx.doi.org/10.1007/s13365-019-00736-zDOI Listing

Prevalence of Cognitive Impairment and Its Predictors among HIV/AIDS Patients on Antiretroviral Therapy in Jimma University Medical Center, Southwest Ethiopia.

Psychiatry J 2019 13;2019:8306823. Epub 2019 Mar 13.

Department of Biomedical Sciences, College of Medicine and Health Science, Wolkite University, Wolkite, Ethiopia.

Background: Cognitive impairment among human immunodeficiency virus (HIV) infected patients can lead to treatment nonadherence, faster progression of the illness, disability, and bed ridden state if we fail to detect it early. However, there is scarcity of previous published studies in Ethiopia on the assessment of cognitive impairment among HIV-positive patients. Hence, this study aimed to determine the prevalence and associated factors of cognitive impairment among HIV-positive patients receiving antiretroviral therapy (ART) at Jimma University Medical Center, Ethiopia. Read More

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https://www.hindawi.com/journals/psychiatry/2019/8306823/
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http://dx.doi.org/10.1155/2019/8306823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436374PMC
March 2019
1 Read

Sex-specific neurogenic deficits and neurocognitive disorders in middle-aged HIV-1 Tg26 transgenic mice.

Brain Behav Immun 2019 Apr 16. Epub 2019 Apr 16.

Center for Metabolic Disease Research, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, United States; Department of Pathology and Laboratory Medicine, Temple University Lewis Katz School of Medicine, 3500 N Broad Street, Philadelphia, PA 19140, United States. Electronic address:

Varying degrees of cognitive deficits affect over half of all HIV-1 infected patients. Because of antiretroviral treatment (ART) regimens, the HIV-1 patient population is increasing in age. Very few epidemiological studies have focused on sex-specific differences in HIV-1-associated neurocognitive disorders (HAND). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08891591183060
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http://dx.doi.org/10.1016/j.bbi.2019.04.029DOI Listing
April 2019
3 Reads

ABC transporters in neurological disorders: an important gateway for botanical compounds mediated neuro-therapeutics.

Curr Top Med Chem 2019 Apr 12. Epub 2019 Apr 12.

Unit of Microbiology and Molecular Biology, ICMR-Vector Control Research Center, Puducherry-605006. India.

Neurodegeneration is a distinguishing feature of many age related disorders. There are a number of factors that can modulate the pathology of these disorders. ATP-binding cassette (ABC) transporters are primarily involved in the maintenance of normal brain homeostasis by eliminating toxic peptides and compounds from the brain. Read More

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http://dx.doi.org/10.2174/1568026619666190412121811DOI Listing
April 2019
6 Reads
3.402 Impact Factor

High prevalence of neurocognitive disorders observed among adult people living with HIV/AIDS in Southern Ethiopia: A cross-sectional study.

PLoS One 2019 18;14(3):e0204636. Epub 2019 Mar 18.

Arbaminch University College of Medicine and Health Sciences Department of Public Health, Arbaminch, Ethiopia.

Background: Comprehensive care given to people living with HIV/AIDS is improving over time; however, their concurrent cognitive illness is still ignored, under screened and treated particularly in developing countries. And this problem is also striking in Ethiopia. Therefore, the objective of this study was to assess HIV-associated neurocognitive disorders and associated factors among adult people living with HIV/AIDS. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0204636PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6422272PMC
March 2019
10 Reads

Trajectory of Physical Functioning Among Persons Living With HIV in Nursing Homes.

J Am Med Dir Assoc 2019 Apr 4;20(4):497-502. Epub 2019 Mar 4.

Department of Health Services, Policy & Practice, Brown University School of Public Health, Providence, RI.

Objective(s): To examine the change in physical functional status among persons living with HIV (PLWH) in nursing homes (NHs) and how change varies with age and dementia.

Design: Retrospective cohort study.

Setting: NHs in 14 states in the United States. Read More

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http://dx.doi.org/10.1016/j.jamda.2019.01.126DOI Listing
April 2019
1 Read

Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder.

Gene 2019 May 27;698:41-49. Epub 2019 Feb 27.

Department of Microbiology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow 226014, India.

Matrix metalloproteinases (MMPs) play a key role in several diseases such as rheumatoid arthritis, HIV-associated neurological diseases (HAND), multiple sclerosis, osteoporosis, stroke, Alzheimer's disease, certain viral infections of the central nervous system, cancer, and hepatitis C virus. MMPs have been explained with regards to extracellular matrix remodeling, which occurs throughout life and ranges from tissue morphogenesis to wound healing in various processes. MMP are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). Read More

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http://dx.doi.org/10.1016/j.gene.2019.02.057DOI Listing
May 2019
3 Reads

Impaired Neurocognitive Performance and Mortality in HIV: Assessing the Prognostic Value of the HIV-Dementia Scale.

AIDS Behav 2019 Feb 28. Epub 2019 Feb 28.

Department of Psychology, University of Miami, 5665 Ponce de Leon Blvd., Coral Gables, FL, 33124-0751, USA.

This study examined whether global HIV-associated neurocognitive impairment (NCI), assessed with the HIV-Dementia Scale (HDS), predicted mortality in an ethnically diverse sample of 209 HIV-positive adults. Participants were predominantly in the mid-range of illness at baseline, and followed over 13-years. At baseline, 31 (15%) participants scored in the NCI range (HDS ≤ 10); 58 (28%) died during follow-up. Read More

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http://link.springer.com/10.1007/s10461-019-02423-w
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http://dx.doi.org/10.1007/s10461-019-02423-wDOI Listing
February 2019
5 Reads

Progressive brain atrophy in chronically infected and treated HIV+ individuals.

J Neurovirol 2019 Feb 14. Epub 2019 Feb 14.

Department of Public Health, Infection Unit, Tufts University School of Medicine, Boston, MA, USA.

Growing evidence points to persistent neurological injury in chronic HIV infection. It remains unclear whether chronically HIV-infected individuals on combined antiretroviral therapy (cART) develop progressive brain injury and impaired neurocognitive function despite successful viral suppression and immunological restoration. In a longitudinal neuroimaging study for the HIV Neuroimaging Consortium (HIVNC), we used tensor-based morphometry to map the annual rate of change of regional brain volumes (mean time interval 1. Read More

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http://dx.doi.org/10.1007/s13365-019-00723-4DOI Listing
February 2019
3 Reads

Methamphetamine and its immune-modulating effects.

Maturitas 2019 Mar 5;121:13-21. Epub 2018 Dec 5.

Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia. Electronic address:

The recreational use of methamphetamine (METH, or ice) is a global burden. It pervades and plagues contemporary society; it has been estimated that there are up to 35 million users worldwide. METH is a highly addictive psychotropic compound which acts on the central nervous system, and chronic use can induce psychotic behavior. Read More

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http://dx.doi.org/10.1016/j.maturitas.2018.12.003DOI Listing
March 2019
3 Reads
2.942 Impact Factor

Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders.

Curr HIV/AIDS Rep 2019 Feb;16(1):76-81

Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, 416 45, Gothenburg, Sweden.

Purpose Of Review: The aim of this study was to examine the synaptic biomarker neurogranin in cerebrospinal fluid (CSF) in different stages of HIV infection and in relation to what is known about CSF neurogranin in other neurodegenerative diseases.

Recent Findings: CSF concentrations of neurogranin are increased in Alzheimer's disease, but not in other neurodegenerative disorder such as Parkinson's disease, frontotemporal dementia, and Lewy body dementia. Adults with HIV-associated dementia have been found to have decreased levels of neurogranin in the frontal cortex, which at least to some extent, may be mediated by the proinflammatory cytokines IL-1β and IL-8. Read More

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http://dx.doi.org/10.1007/s11904-019-00420-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420419PMC
February 2019
6 Reads

Vascular cognitive impairment and HIV-associated neurocognitive disorder: a new paradigm.

J Neurovirol 2019 Jan 11. Epub 2019 Jan 11.

UNSW Medicine, UNSW Sydney, Sydney, NSW, Australia.

In this review, we propose that vascular cognitive impairment (VCI), with relevance for the global HIV population, is fundamentally and clinically linked to the persistence of mild forms of HIV-associated neurocognitive disorders (HAND) in ageing people living with HIV infection (PLWH). After placing our review within the context of the general literature on HIV and ageing, we review non-VCI risks for dementia in ageing PLWH. We then present the recently updated VCI nomenclature and show that the neuropsychological and neuroimaging phenotypes of VCI and HAND are largely overlapping, suggesting that further research is needed to accurately distinguish them. Read More

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http://link.springer.com/10.1007/s13365-018-0706-5
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http://dx.doi.org/10.1007/s13365-018-0706-5DOI Listing
January 2019
15 Reads

Brain structural correlates of trajectories to cognitive impairment in men with and without HIV disease.

Brain Imaging Behav 2019 Jan 9. Epub 2019 Jan 9.

Department of Psychiatry, University of Pittsburgh, Suite 830, 3501 Forbes Avenue, Pittsburgh, PA, 15213, USA.

There are distinct trajectories to cognitive impairment among participants in the Multicenter AIDS Cohort Study (MACS). Here we analyzed the relationship between regional brain volumes and the individual trajectories to impairment in a subsample (n = 302) of the cohort. 302 (167 HIV-infected; mean age = 55. Read More

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http://dx.doi.org/10.1007/s11682-018-0026-7DOI Listing
January 2019
4 Reads

Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease.

J Neurovirol 2019 Jan 4. Epub 2019 Jan 4.

Laboratory of Neurosciences, Intramural Research Program, National Institute on Aging/National Institutes of Health (NIA/NIH), Bethesda, USA.

Fluid biomarkers for cognitive impairment have the advantage of being relatively noninvasive and capable of monitoring neuronal and other brain cell health in real time. Biomarkers can predict the onset of dementing illness, but also correlate with cognition in a dynamic way allowing us to follow treatment responses and determine brain recovery. Chronic HIV infection causes cognitive impairment in a subset of individuals suggesting "premature aging. Read More

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http://dx.doi.org/10.1007/s13365-018-0695-4DOI Listing
January 2019
25 Reads

AAOS Systematic Literature Review: Summary on the Management of Surgical Site Infections.

J Am Acad Orthop Surg 2018 Dec 28. Epub 2018 Dec 28.

From Orthopaedic Surgery, University of Arizona, College of Medicine-Phoenix, Phoenix, AZ (Dr. McLaren), and Resurgens Orthopaedics, Atlanta, GA (Dr. Lundy).

The purpose of this systematic review is to improve outcomes for the care of surgical site infections by presenting the current best evidence on important diagnostic and care issues. The findings led to ten recommendations and five consensus statements that address diagnosis and treatment of orthopaedic surgical site infections. There is strong evidence to supports anemia, obesity, HIV/AIDS, depression, dementia, immunosuppressive medications, duration of hospital stay, history of alcohol abuse, and history of congestive heart failure as factors that increased the risk of infection, some of which are modifiable before surgical intervention. Read More

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http://dx.doi.org/10.5435/JAAOS-D-18-00653DOI Listing
December 2018
2 Reads

Icariside II attenuates lipopolysaccharide-induced neuroinflammation through inhibiting TLR4/MyD88/NF-κB pathway in rats.

Biomed Pharmacother 2019 Mar 24;111:315-324. Epub 2018 Dec 24.

Key Laboratory of Basic Pharmacology of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China; Joint International Research Laboratory of Ethnomedicine of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563003, China. Electronic address:

Inflammation in central nervous system (CNS) plays a vital role in neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Lewy body dementia (DLB), HIV-related dementia and traumatic brain injury. Icariside II (ICS II), an active flavonoid compound derived from a Chinese herbal medicine Epimedium brevicornum Maxim, has been shown to possess a neuroprotective effect on AD model. However, whether ICS II has a directly protective effect on acute neuroinflammation remains still unclear. Read More

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http://dx.doi.org/10.1016/j.biopha.2018.10.201DOI Listing
March 2019
5 Reads

CSF concentrations of soluble TREM2 as a marker of microglial activation in HIV-1 infection.

Neurol Neuroimmunol Neuroinflamm 2019 Jan 7;6(1):e512. Epub 2018 Nov 7.

Department of Infectious Diseases (M.G., A.Y., L.-M.A., L.H.), Institute of Biomedicine, the Sahlgrenska Academy at University of Gothenburg, Sweden; Department of Molecular Neuroscience (A.H., E.V., H.Z.), UCL Institute of Neurology, Queen Square; UK Dementia Research Institute at UCL (A.H., E.V., H.Z.), London, United Kingdom; Department of Neurology and Center for Neuroepidemiology and Clinical Neurological Research (S.S.), Yale University, New Haven, CT; Division of Biological Chemistry (D.F.), Biocenter, Medical University of Innsbruck, Austria; Department of Neurology (R.W.P.), University of California San Francisco; Clinical Neurochemistry Laboratory (H.Z.), Sahlgrenska University Hospital; and Department of Psychiatry and Neurochemistry (H.Z.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.

Objective: To explore changes in CSF sTREM2 concentrations in the evolving course of HIV-1 infection.

Methods: In this retrospective cross-sectional study, we measured concentrations of the macrophage/microglial activation marker sTREM2 in CSF samples from 121 HIV-1-infected adults and 11 HIV-negative controls and examined their correlations with other CSF and blood biomarkers of infection, inflammation, and neuronal injury.

Results: CSF sTREM2 increased with systemic and CNS HIV-1 disease severity, with the highest levels found in patients with HIV-associated dementia (HAD). Read More

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http://dx.doi.org/10.1212/NXI.0000000000000512DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6278890PMC
January 2019
5 Reads

Lower Neurocognitive Functioning Disrupts the Effective Use of Internet-Based Health Resources in HIV Disease: The Mediating Effects of General Health Literacy Capacity.

AIDS Behav 2019 Mar;23(3):676-683

Department of Psychology, University of Houston, 126 Heyne Building, Houston, TX, 77004-5022, USA.

HIV-associated neurocognitive impairment is an independent predictor of low general health literacy, which can be associated with poor disease outcomes (e.g., viremia). Read More

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http://dx.doi.org/10.1007/s10461-018-2350-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408228PMC
March 2019
3 Reads

Community-based supplementary feeding for food insecure, vulnerable and malnourished populations - an overview of systematic reviews.

Cochrane Database Syst Rev 2018 11 9;11:CD010578. Epub 2018 Nov 9.

Division of Human Nutrition, Stellenbosch University, Francie van Zijl Drive, Cape Town, Western Cape, South Africa, 7505.

Background: Supplementary feeding may help food insecure and vulnerable people by optimising the nutritional value and adequacy of the diet, improving quality of life and improving various health parameters of disadvantaged families. In low- and middle-income countries (LMIC), the problems supplementary feeding aims to address are entangled with poverty and deprivation, the programmes are expensive and delivery is complicated.

Objectives: 1. Read More

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http://doi.wiley.com/10.1002/14651858.CD010578.pub2
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http://dx.doi.org/10.1002/14651858.CD010578.pub2DOI Listing
November 2018
15 Reads

Risk Factors and Pathogenesis of HIV-Associated Neurocognitive Disorder: The Role of Host Genetics.

Int J Mol Sci 2018 Nov 14;19(11). Epub 2018 Nov 14.

Division of Physiological Sciences, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Observatory 7925, South Africa.

Neurocognitive impairments associated with human immunodeficiency virus (HIV) infection remain a considerable health issue for almost half the people living with HIV, despite progress in HIV treatment through combination antiretroviral therapy (cART). The pathogenesis and risk factors of HIV-associated neurocognitive disorder (HAND) are still incompletely understood. This is partly due to the complexity of HAND diagnostics, as phenotypes present with high variability and change over time. Read More

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http://www.mdpi.com/1422-0067/19/11/3594
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http://dx.doi.org/10.3390/ijms19113594DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274730PMC
November 2018
25 Reads

Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovirus reactivation in an HIV-infected patient.

BMC Infect Dis 2018 Nov 12;18(1):554. Epub 2018 Nov 12.

Infectious Diseases Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

Background: Cytomegalovirus (CMV) reactivation with neurological involvement in patients with acquired immunodeficiency syndrome (AIDS) is increasingly rare since the introduction of antiretroviral therapy (ART). Manifestations include encephalitis, myelitis, polyradiculopathy and, less commonly, mononeuritis multiplex (MNM). We report a case of disseminated CMV disease with gastrointestinal and peripheral and central nervous system involvement in a patient with AIDS, manifesting primarily as MNM. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3501-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233374PMC
November 2018
21 Reads

Human Immunodeficiency Virus and the Nervous System.

Neurol Clin 2018 Nov;36(4):751-765

Department of Neurology, HIV Medicine, Neurosciences Program, Peter Duncan Neurosciences Unit, St Vincent's Hospital, St Vincent's Centre for Applied Medical Research, University of New South Wales, University of Notre Dame, Level 4 Xavier Building, Victoria Street, Darlinghurst, Sydney, Australia. Electronic address:

In the era of combination antiretroviral therapy, the diagnosis and management of HIV-associated neurocognitive disorders (HANDs) has arisen. Traditionally, severe HAND was seen in those with untreated HIV infection and had a guarded prognosis. Antiretroviral therapy has provided longevity and viral control to many living with the disease, revealing an increase in prevalence of less severe forms of HAND. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07338619183124
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http://dx.doi.org/10.1016/j.ncl.2018.07.002DOI Listing
November 2018
20 Reads

What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?

Sao Paulo Med J 2018 Sep-Oct;136(5):472-478. Epub 2018 Oct 22.

MD, MSc, PhD. Rheumatologist; Adjunct Professor, Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP); and Researcher, Cochrane Brazil, São Paulo (SP), Brazil.

Background: The therapeutic effects of cannabinoid compounds have been the center of many investigations. This study provides a synthesis on all Cochrane systematic reviews (SRs) that assessed the use of cannabinoids as a therapeutic approach.

Design And Setting: Review of SRs, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina (EPM), Universidade Federal de São Paulo (UNIFESP). Read More

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http://dx.doi.org/10.1590/1516-3180.2018.0313210818DOI Listing
February 2019
4 Reads

Withaferin A Suppresses Beta Amyloid in APP Expressing Cells: Studies for Tat and Cocaine Associated Neurological Dysfunctions.

Front Aging Neurosci 2018 27;10:291. Epub 2018 Sep 27.

Institute of NeuroImmune Pharmacology, Center for Personalized Nanomedicine, Department of Immunology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, United States.

Neurological disorders are the biggest concern globally. Out of ~36 million human immunodeficiency virus (HIV) positive people, about 30%-60% exhibit neurological disorders, including dementia and Alzheimer's disease (AD) like pathology. In AD or AD like neurological disorders, the pathogenesis is mainly due to the abnormal accumulation of extracellular amyloid beta (Aβ). Read More

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http://dx.doi.org/10.3389/fnagi.2018.00291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190869PMC
September 2018
4 Reads
2.843 Impact Factor

Drug targeting strategies into the brain for treating neurological diseases.

Authors:
Wilson Barnabas

J Neurosci Methods 2019 Jan 16;311:133-146. Epub 2018 Oct 16.

Department of Pharmaceutics, College of Pharmaceutical Sciences, Dayananda Sagar University, Kumaraswamy Layout, Bangalore, Karnataka 560078, India. Electronic address:

Brain specific drug delivery is one of the most interesting and challenging areas of research. The blood-brain barrier separates the brain from blood and acts as a barrier to protect the brain from microorganisms, neurotoxins and chemical substances. But, the same mechanism poses an obstacle for the entry of many drugs into the brain. Read More

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http://dx.doi.org/10.1016/j.jneumeth.2018.10.015DOI Listing
January 2019
7 Reads

Atrophic brain signatures of mild forms of neurocognitive impairment in virally suppressed HIV infection.

AIDS 2019 Jan;33(1):55-66

Neuroscience Research Australia.

Objective: There is a lack of evidence for the neurobiological underpinning of asymptomatic neurocognitive impairment (ANI) and mild neurocognitive disorders (MNDs) in virally suppressed HIV-positive persons. We hypothesized that such mild impairment would be associated with focal brain atrophy.

Design: A cross-sectional observational study. Read More

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http://dx.doi.org/10.1097/QAD.0000000000002042DOI Listing
January 2019
13 Reads

A central role for glial CCR5 in directing the neuropathological interactions of HIV-1 Tat and opiates.

J Neuroinflammation 2018 Oct 10;15(1):285. Epub 2018 Oct 10.

Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, 1217 E. Marshall St, Richmond, VA, 23298-0709, USA.

Background: The collective cognitive and motor deficits known as HIV-associated neurocognitive disorders (HAND) remain high even among HIV+ individuals whose antiretroviral therapy is optimized. HAND is worsened in the context of opiate abuse. The mechanism of exacerbation remains unclear but likely involves chronic immune activation of glial cells resulting from persistent, low-level exposure to the virus and viral proteins. Read More

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https://jneuroinflammation.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s12974-018-1320-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180355PMC
October 2018
7 Reads

A neuropathologic diagnosis of Alzheimer's disease in an older adult with HIV-associated neurocognitive disorder.

Neurocase 2018 Aug 10;24(4):213-219. Epub 2018 Oct 10.

a Memory and Aging Center, Department of Neurology , University of California, San Francisco , California, CA , USA.

We discuss the challenges associated with diagnosing neurodegenerative disorders in older adults living with HIV, illustrated through a case report where neurologic co-diagnosis of Alzheimer's disease (AD) and HIV-associated Neurocognitive Disorder (HAND) are considered. The patient was followed and evaluated for over 4 years and underwent post-mortem neuropathologic evaluation. Further work is needed to identify diagnostic tests that can adequately distinguish HAND from early stage neurodegenerative disorders among older adults living with HIV and cognitive changes. Read More

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http://dx.doi.org/10.1080/13554794.2018.1530362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6226354PMC
August 2018
12 Reads

HIV-1-Associated Neurocognitive Disorders: Is HLA-C Binding Stability to β-Microglobulin a Missing Piece of the Pathogenetic Puzzle?

Front Neurol 2018 21;9:791. Epub 2018 Sep 21.

Department of Diagnostics and Public Health, University of Verona, Verona, Italy.

AIDS dementia complex (ADC) and HIV-associated neurocognitive disorders (HAND) are complications of HIV-1 infection. Viral infections are risk factors for the development of neurodegenerative disorders. Aging is associated with low-grade inflammation in the brain, i. Read More

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http://dx.doi.org/10.3389/fneur.2018.00791DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6160745PMC
September 2018
9 Reads

HIV Neuroinfection and Alzheimer's Disease: Similarities and Potential Links?

Front Cell Neurosci 2018 11;12:307. Epub 2018 Sep 11.

Pathogenesis and Control of Chronic Infections, INSERM, University of Montpellier, Etablissement français du Sang, Montpellier, France.

Environmental factors such as chemicals, stress and pathogens are now widely believed to play important roles in the onset of some brain diseases, as they are associated with neuronal impairment and acute or chronic inflammation. Alzheimer's disease (AD) is characterized by progressive synaptic dysfunction and neurodegeneration that ultimately lead to dementia. Neuroinflammation also plays a prominent role in AD and possible links to viruses have been proposed. Read More

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http://dx.doi.org/10.3389/fncel.2018.00307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6141679PMC
September 2018
5 Reads

Intraindividual variability in neuropsychological performance predicts cognitive decline and death in HIV.

Neuropsychology 2018 Nov 13;32(8):966-972. Epub 2018 Sep 13.

Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Geffen School of Medicine.

Objective: HIV-associated neurocognitive disorder (HAND) occurs in a significant percentage of HIV-infected (HIV+) adults. Increased intraindividual variability (IIV) in cognitive function may be an early marker of emerging neurocognitive disorder, which suggests that IIV may be a sensitive measure of neurologic compromise in HIV. In the current study, we hypothesize that increased IIV may predict impending morbidity, including future cognitive decline and death. Read More

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http://dx.doi.org/10.1037/neu0000482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6234088PMC
November 2018
4 Reads

FACTORS AFFECTING THE FATAL OUTCOME IN HIV-INFECTED PATIENTS WITH ENCEPHALITIS.

Georgian Med News 2018 Jul-Aug(280-281):85-89

Kharkiv National Medical University, Ukraine.

Despite the successful use of ART up to 40-70% of HIV(+) individuals have neurologic complications caused both by the HIV itself and by the reactivation of OIs on the background of severe immunodeficiency. Nowadays, there are no universally recognized criteria that allow predicting the outcome of encephalitis caused by OIs in this category of patients. The aim of our study was to assess factors affecting the fatal outcome in HIV(+) patients with CNS involvement. Read More

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December 2018
3 Reads

Protein Targets of Frankincense: A Reverse Docking Analysis of Terpenoids from Oleo-Gum Resins.

Medicines (Basel) 2018 Aug 31;5(3). Epub 2018 Aug 31.

Department of Chemistry, University of Alabama in Huntsville, Huntsville, AL 35899, USA.

Frankincense, the oleo-gum resin of trees, has been used in traditional medicine since ancient times. Frankincense has been used to treat wounds and skin infections, inflammatory diseases, dementia, and various other conditions. However, in many cases, the biomolecular targets for frankincense components are not well established. Read More

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http://dx.doi.org/10.3390/medicines5030096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6163972PMC
August 2018
5 Reads

A Quantitative Approach to SIV Functional Latency in Brain Macrophages.

J Neuroimmune Pharmacol 2019 Mar 30;14(1):23-32. Epub 2018 Aug 30.

Department of Molecular and Comparative Pathobiology, Johns Hopkins University, Baltimore, MD, 21205, USA.

Lentiviruses are retroviruses that primarily infect myeloid cells, leading to acute inflammatory infections in many tissues particularly, lung, joints and the central nervous system (CNS). Acute infection by lentiviruses is followed by persistent/latent infections that are not cleared by the host immune system. HIV and SIV are lentiviruses that also infect CD4+ lymphocytes as well as myeloid cells in blood and multiple tissues. Read More

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http://link.springer.com/10.1007/s11481-018-9803-8
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http://dx.doi.org/10.1007/s11481-018-9803-8DOI Listing
March 2019
14 Reads

Neuroprotective effects of bergenin in Alzheimer's disease: Investigation through molecular docking, in vitro and in vivo studies.

Behav Brain Res 2019 01 14;356:18-40. Epub 2018 Aug 14.

Institute of Pharmacy, Nirma University, S. G. Highway, Ahmedabad, Gujarat, 382481, India. Electronic address:

Alzheimer's disease (AD) is an enervating and chronic progressive neurodegenerative disorder, occurring frequently in the elderly and adversely affecting intellectual capabilities and the cognitive processes. Bergenin possesses efficacious antioxidant, antiulcerogenic, anti-HIV, hepatoprotective, neuroprotective, anti-inflammatory and immunomodulatory activity along with antinociceptive effect and wound healing properties. Previous studies have shown that bergenin has in vitro bovine adrenal tyrosine hydroxylase inhibitory activity, mushroom tyrosinase inhibitory activities, β-secretase (BACE-1) enzyme inhibitory activity and prevented neuronal death in the primary culture of rat cortical neurons. Read More

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http://dx.doi.org/10.1016/j.bbr.2018.08.010DOI Listing
January 2019
23 Reads

Alzheimer's disease neuropathology may not predict functional impairment in HIV: a report of two individuals.

J Neurovirol 2018 Oct 9;24(5):629-637. Epub 2018 Aug 9.

Department of Neuroscience and Pathology, The Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

With aging of HIV populations, there is concern that Alzheimer's disease (AD) may become prevalent and difficult to distinguish from HIV-associated neurocognitive disorders. To date, there are no reports documenting histologically verified Alzheimer's neuropathology in individuals with HIV and dementia. Herein, we report two antiretroviral-treated, virally suppressed, HIV-infected individuals autopsied by the Manhattan HIV Brain Bank. Read More

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http://dx.doi.org/10.1007/s13365-018-0663-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202220PMC
October 2018
16 Reads

Aberrant oscillatory dynamics during somatosensory processing in HIV-infected adults.

Neuroimage Clin 2018 10;20:85-91. Epub 2018 Jul 10.

Department of Neurological Sciences, University of Nebraska Medical Center (UNMC), Omaha, NE, USA; Center for Magnetoencephalography, UNMC, Omaha, NE, USA. Electronic address:

While the arrival of combination antiretroviral therapy significantly decreased the prevalence of HIV-associated dementia, between 35 and 70% of all infected adults continue to develop some form of cognitive impairment. These deficits appears to affect multiple neural subsystems, but the mechanisms and extent of damage are not fully understood. In the current study, we utilized magnetoencephalography (MEG), advanced oscillatory analysis methods, and a paired-pulse somatosensory stimulation paradigm to interrogate pre-attentive inhibitory processing in 43 HIV-infected adults and 28 demographically-matched uninfected controls. Read More

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http://dx.doi.org/10.1016/j.nicl.2018.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6070689PMC
January 2019
20 Reads

Recent advancement toward significant association between disordered transcripts and virus-infected diseases: a survey.

Brief Funct Genomics 2018 11;17(6):458-470

Department of Computer Science and Engineering, Jadavpur University, Kolkata, India.

In the current era of epigenetics research, we have observed many examples of epigenetic modifications, like histone modification and DNA methylation, in various fatal diseases. These include solid tumors, hematological malignancies and viral infections with DNA or RNA viruses. The purpose of this review is to summarize the role of epigenetic modifications during the abovementioned viral infections, viral-associated and independent malignancies. Read More

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http://dx.doi.org/10.1093/bfgp/ely021DOI Listing
November 2018
3 Reads
3.670 Impact Factor

Neuropsychiatric Symptoms and Caregiver Burden in Individuals With Alzheimer's Disease: The TEAM-AD VA Cooperative Study.

J Geriatr Psychiatry Neurol 2018 07 2;31(4):177-185. Epub 2018 Jul 2.

15 Bronx Veterans Medical Research Center, New York, NY, USA.

Objectives: To assess the prevalence of neuropsychiatric symptoms (NPS) in mild-to-moderate Alzheimer disease (AD) and their association with caregiver burden.

Methods: Secondary analyses of baseline data from the Trial of Vitamin E and Memantine in Alzheimer's Disease (TEAM-AD) (N=613). Neuropsychiatric Inventory were used to measure severity of NPS and caregiver activity survey to measure caregiver burden. Read More

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http://dx.doi.org/10.1177/0891988718783897DOI Listing
July 2018
15 Reads

The Impact of Alcohol Use on Frontal White Matter in HIV.

Alcohol Clin Exp Res 2018 Sep 16;42(9):1640-1649. Epub 2018 Jul 16.

Center for Cognitive Aging and Memory , McKnight Brain Institute, University of Florida, Gainesville, Florida.

Background: Alcohol use disorder (AUD) is prevalent among individuals diagnosed with human immunodeficiency virus (HIV), and both HIV and alcohol use have been shown to negatively affect the integrity of white matter pathways in the brain. Behavioral, functional, and anatomical impairments have been linked independently to HIV and alcohol use, and these impairments have bases in specific frontally mediated pathways within the brain.

Methods: Magnetic resonance imaging data were acquired for 37 HIV+ participants without dementia or hepatitis C. Read More

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http://dx.doi.org/10.1111/acer.13823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6120768PMC
September 2018
42 Reads

HIV and Aging - Perhaps Not as Dramatic as We Feared?

Gerontology 2018 15;64(5):446-456. Epub 2018 Jun 15.

University Department of Medicine and Infectious Diseases Service, Kantonsspital Baselland, University of Basel, Bruderholz, Switzerland.

Ever since the introduction of highly active antiretroviral therapy (ART) in 1995, HIV infection has been linked to "metabolic" complications (insulin resistance, dyslipidemia, osteoporosis, and others). Studies suggested increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures in HIV-postitive patients. Even long-term suppression of HIV seemed to be accompanied by an excess of deleterious inflammation that could promote these complications. Read More

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http://dx.doi.org/10.1159/000489172DOI Listing
December 2018
21 Reads

Comparison of two screening tests for HIV-Associated Neurocognitive Disorder suspected Japanese patients with respect to cART usage.

PLoS One 2018 14;13(6):e0199106. Epub 2018 Jun 14.

Department of Infectious Diseases, Respiratory, and Digestive Medicine, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.

In this study, we demonstrated the pervasiveness of HIV-associated neurocognitive disorders (HAND) among a selection of Japanese patients as well as evaluated and compared the Mini Mental State Examination (MMSE) and the International HIV Dementia Scale (IHDS) for use as a screening tool among combination anti-retroviral therapy (cART)-naïve and cART experienced patients. The MMSE and the IHDS have both been used as HAND screening tests around the world with variable success. It has been reported the increased usage of cART the utility of these screening tests may have been diminished due to the decreased severity of impairment and the altered pattern of neurocognitive impairments in cART era HAND patients. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0199106PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6002083PMC
December 2018
38 Reads

and invasive central nervous system infection.

SAGE Open Med Case Rep 2018 31;6:2050313X18775584. Epub 2018 May 31.

Division of Infectious Disease & HIV Medicine, Department of Medicine, Drexel University College of Medicine, Hahnemann University Hospital, Philadelphia, PA, USA.

is a Gram-positive beta-hemolytic bacteria, also known as group A streptococci, that causes a range of infections. The most common presentation is acute pharyngitis; however, it is also implicated in skin and soft tissue infections, and less commonly bacteremia, osteomyelitis, pneumonia, otitis media and sinusitis. Group A streptococci infections of the central nervous system are exceedingly rare in the antibiotic era. Read More

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http://dx.doi.org/10.1177/2050313X18775584DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5985606PMC
May 2018
24 Reads

Sulfonamide inhibitors: a patent review 2013-present.

Expert Opin Ther Pat 2018 Jul 19;28(7):541-549. Epub 2018 Jun 19.

a Department of Chemistry, Faculty of Sciences , Ataturk University , Erzurum , Turkey.

Introduction: Sulfonamide compounds are significant class of synthetic bacteriostatic antibiotics still which used today for the therapy of bacterial infections and those caused by other microorganisms. They are also known as sulfa drugs and were the main source of therapy against bacterial infections before the introduction of penicillin in 1941. Additionally, The first sulfonamide section is present inmany clinically used drugs such as diuretics, carbonic anhydrase inhibitors and antiepileptics. Read More

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http://dx.doi.org/10.1080/13543776.2018.1487400DOI Listing
July 2018
27 Reads
4.300 Impact Factor

Neurological soft signs as a marker of cognitive impairment severity in people living with HIV.

Psychiatry Res 2018 08 16;266:138-142. Epub 2018 May 16.

Department of Psychiatry, Medicine School, Pontificia Universidad Catolica de Chile, Santiago, Chile.

HIV-associated neurocognitive disorders (HAND) include asymptomatic neurocognitive impairment (ANI), mild neurocognitive disorder (MND) and HIV-associated dementia. Early recognition of HAND is crucial, and usually requires thorough neuropsychological testing. Neurological soft signs (NSS), i. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.04.062DOI Listing
August 2018
10 Reads

Oral Microbiome in HIV-Infected Women: Shifts in the Abundance of Pathogenic and Beneficial Bacteria Are Associated with Aging, HIV Load, CD4 Count, and Antiretroviral Therapy.

AIDS Res Hum Retroviruses 2019 Mar 23;35(3):276-286. Epub 2018 Jul 23.

1 Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, California.

Human immunodeficiency virus (HIV)-associated nonacquired immunodeficiency syndrome (AIDS) conditions, such as cardiovascular disease, diabetes, osteoporosis, and dementia are more prevalent in older than in young adult HIV-infected subjects. Although the oral microbiome has been studied as a window into pathogenesis in aging populations, its relationship to HIV disease progression, opportunistic infections, and HIV-associated non-AIDS conditions is not well understood. We utilized 16S rDNA-based pyrosequencing to compare the salivary microbiome in three groups: (1) Chronically HIV-infected women >50 years of age (aging); (2) HIV-infected women <35 years of age (young adult); and (3) HIV-uninfected age-matched women. Read More

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http://www.liebertpub.com/doi/10.1089/aid.2017.0200
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http://dx.doi.org/10.1089/AID.2017.0200DOI Listing
March 2019
17 Reads
2.330 Impact Factor

HIV disease and diabetes interact to affect brain white matter hyperintensities and cognition.

AIDS 2018 Aug;32(13):1803-1810

Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Since the onset of combination antiretroviral therapy use, the incidence of HIV-associated dementia and of HIV encephalitis has fallen dramatically. The present study investigates the extent of white matter hyperintensities (WMHs) among individuals with HIV disease, and factors that predict their presence and their impact on psychomotor speed.

Methods: A total of 322 men participating in the Multicenter AIDS Cohort Study (185 HIV-infected, age: 57. Read More

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http://dx.doi.org/10.1097/QAD.0000000000001891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082131PMC
August 2018
15 Reads

HIV Dementia with a Decreased Cardiac I-metaiodobenzylguanidine Uptake Masquerading as Dementia with Lewy Bodies.

Intern Med 2018 Oct 18;57(20):3007-3010. Epub 2018 May 18.

Department of Neurology, Graduate School of Medicine, The University of Tokyo, Japan.

Cardiac I-metaiodobenzylguanidine (MIBG) scintigraphy is a promising biomarker for dementia with Lewy bodies (DLB). However, we experienced a patient with cognitive decline, parkinsonism, and a decreased MIBG uptake who turned out to have HIV dementia. Normal dopamine transporter single-photon emission computed tomography reduced the possibility of comorbid Lewy body pathology causing the patient' s parkinsonism. Read More

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http://dx.doi.org/10.2169/internalmedicine.0876-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6232034PMC
October 2018
5 Reads

Charlson comorbidity index as a predictor of periodontal disease in elderly participants.

J Periodontal Implant Sci 2018 Apr 30;48(2):92-102. Epub 2018 Apr 30.

Department of Periodontology, Research Institute for Periodontal Regeneration, Yonsei University College of Dentistry, Seoul, Korea.

Purpose: This study investigated the validity of the Charlson comorbidity index (CCI) as a predictor of periodontal disease (PD) over a 12-year period.

Methods: Nationwide representative samples of 149,785 adults aged ≥60 years with PD (International Classification of Disease, 10th revision [ICD-10], K052-K056) were derived from the National Health Insurance Service-Elderly Cohort during 2002-2013. The degree of comorbidity was measured using the CCI (grade 0-6), including 17 diseases weighted on the basis of their association with mortality, and data were analyzed using multivariate Cox proportional-hazards regression in order to investigate the associations of comorbid diseases (CDs) with PD. Read More

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https://synapse.koreamed.org/DOIx.php?id=10.5051/jpis.2018.4
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http://dx.doi.org/10.5051/jpis.2018.48.2.92DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5944227PMC
April 2018
19 Reads