Prog Brain Res 2022 4;269(1):373-403. Epub 2022 Feb 4.
Neurodegenerative Disease Group, Montreal Neurological Institute-Hospital (The Neuro), Montreal, Canada; Département de Pharmacologie et Physiologie, Université de Montréal, Montreal, Canada; Department of Neurology and Neurosurgery, McGill University, Montreal, Canada; Movement Disorder Clinic, Division of Neurology, Department of Neurosciences, McGill University Health Centre, Montreal, Canada. Electronic address:
Cognitive impairment affects up to 80% of patients with Parkinson's disease (PD) and is associated with poor quality of life. PD cognitive dysfunction includes poor working memory, impairments in executive function and difficulty in set-shifting. The pathophysiology underlying cognitive impairment in PD is still poorly understood, but there is evidence to support involvements of the cholinergic, dopaminergic, and noradrenergic systems. Read More