8,320 results match your criteria Delusional Disorder


Psychotic-Like Experiences in Offspring of Parents With Bipolar Disorder and Community Controls: A Longitudinal Study.

J Am Acad Child Adolesc Psychiatry 2018 Nov 2. Epub 2018 Nov 2.

University of Pittsburgh, PA.

Objective: To compare the prevalence and risk factors associated with Psychotic-Like-Experiences (PLE) in offspring of parents with bipolar disorder (BP) and offspring of community control parents.

Method: Delusional and hallucinatory subclinical psychotic experiences were evaluated at intake and longitudinally in a cohort study of 390 offspring of BP parents and 247 offspring of control parents aged 6-18 years old. The sample was followed up every 2. Read More

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http://dx.doi.org/10.1016/j.jaac.2018.09.440DOI Listing
November 2018

Postinjection Delirium/Sedation Syndrome After 31st Long-Acting Olanzapine Depot Injection.

Clin Neuropharmacol 2019 Feb 8. Epub 2019 Feb 8.

Department of Psychiatry, Central Institute of Psychiatry, Ranchi, India.

Objective: Long-acting depot preparations of antipsychotics are the mainstay of treatment for patients with schizophrenia who show nonadherence to their medications. Olanzapine pamoate is one of the recently approved long-acting depot psychotropic preparations that have shown its efficacy both in clinical trials and in clinical uses against the illness. However, emerging literature indicates toward a cluster of adverse effects known as postinjection delirium/sedation syndrome (PDSS). Read More

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http://dx.doi.org/10.1097/WNF.0000000000000329DOI Listing
February 2019
2 Reads
1.836 Impact Factor

Leukocytoclastic vasculitis secondary to clozapine.

Indian J Psychiatry 2019 Jan-Feb;61(1):94-96

Department of Clinical and Experimental Pharmacology, School of Tropical Medicine, Kolkata, West Bengal, India.

Leukocytoclastic vasculitis (LCV) may be secondary to drugs, underlying infection, collagen vascular disorders, or malignancy. Drug-induced vasculitis contributes to 10% of vasculitic skin lesions cases usually developing within 7-21 days of treatment initiation. The present case highlights a report of LCV in a 59-year-old male with a history of paranoid schizophrenia on clozapine therapy. Read More

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http://dx.doi.org/10.4103/psychiatry.IndianJPsychiatry_384_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6341920PMC
February 2019
1 Read

Psychoeducational therapy with families of paranoid schizophrenia patients.

Enferm Clin 2019 Feb 8. Epub 2019 Feb 8.

Department of Mental Health Nursing, Poltekkes Kemenkes Semarang, Prodi Keperawatan Magelang, Kota Magelang, Indonesia. Electronic address:

Aim: The study aimed to measure the effectiveness of psychoeducational therapy on the burden of families of paranoid schizophrenia patients.

Methods: An experimental research design was used in this study with an equivalent control group using 84 random allocation samples at a mental hospital in Semarang. The study instrument was the Indonesian version of the care burden scale (CBS). Read More

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http://dx.doi.org/10.1016/j.enfcli.2018.12.006DOI Listing
February 2019
1 Read

Schizotypal traits, neurocognition, and paternal age in unaffected first degree relatives of patients with familial or sporadic schizophrenia.

Psychiatry Res 2019 Jan 2;273:422-429. Epub 2019 Jan 2.

Department of Psychology, Faculty of Social Sciences, University of Crete, Rethymno 74100, Crete, Greece.

Studies comparing cognitive processes between familial and sporadic schizophrenia have yielded inconsistent findings. In this study we examined differences in neurocognition and schizotypal traits in unaffected relatives of schizophrenia-spectrum patients with either the familial (multiplex) or the sporadic (simplex) subtype of the disorder, taking paternal age at birth into consideration. Simplex (n = 65; SR), multiplex (n = 35; MR) relatives and controls (n = 114) were compared on several cognitive functions and schizotypal traits; between-group differences were evaluated with and without including paternal age in the analyses. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183151
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http://dx.doi.org/10.1016/j.psychres.2018.12.142DOI Listing
January 2019
5 Reads

A case report of the successful administration of clozapine in the face of myocardial infarction, pulmonary embolism and hyperlipidaemia resulting in the termination of long-term seclusion.

Authors:
Alex Till Ed Silva

BMC Psychiatry 2019 Jan 23;19(1):37. Epub 2019 Jan 23.

Ashworth Hospital, Mersey Care NHS Trust, Parkbourn, Maghull, Liverpool, Merseyside, L31 1HW, UK.

Background: Cardiometabolic health significantly impacts on the mortality of people with severe mental illness. Clozapine has the greatest efficacy for Treatment Resistant Schizophrenia (TRS) but the greatest negative impact on cardiometabolic health. Balancing the risks and benefits of treatment, dignity, autonomy, liberty, mental and physical health can be challenging, particularly when imposing interventions with potentially life threatening adverse events, such as clozapine. Read More

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http://dx.doi.org/10.1186/s12888-018-2001-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343332PMC
January 2019
2 Reads

Compulsory Psychiatric Admissions in an Italian Urban Setting: Are They Actually Compliant to the Need for Treatment Criteria or Arranged for Dangerous Not Clinical Condition?

Front Psychiatry 2018 8;9:740. Epub 2019 Jan 8.

Department of Clinical and Biological Sciences, University of Turin, Orbassano, Italy.

Italy was one of the first European countries adopting the need for treatment criteria for compulsory admission (CA). The aim of the present study was to confirm whether CA in an urban setting in Italy was compliant with the requested clinical criteria. In this retrospective observational study, we retrieved all collected information regarding CA in Turin (Italy) from January 2006 to December 2013. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00740DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331583PMC
January 2019
1 Read

Gender dysphoria symptoms in schizophrenia.

Psychiatr Pol 2018 Dec 29;52(6):1053-1062. Epub 2018 Dec 29.

Instytut Psychiatrii i Neurologii w Warszawie, III Klinika Psychiatryczna.

Gender dysphoria in individuals with schizophrenia may result from the delusionally changed gender identity or appear regardless of psychotic process. Distinguishing between these situations is not only a diagnostic challenge, but also affects the therapeutic decisionmaking. The review of the literature shows that different delusional beliefs regarding belonging to another gender, anatomy or changes within the genitals affect about one-fourth of patients with schizophrenia. Read More

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http://dx.doi.org/10.12740/PP/80013DOI Listing
December 2018
2 Reads

Long non-coding RNA MIAT competitively binds miR-150-5p to regulate ZEB1 expression in osteosarcoma.

Oncol Lett 2019 Jan 7;17(1):1229-1236. Epub 2018 Nov 7.

Department of Orthopaedics, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150006, P.R. China.

Long non-coding RNAs (LncRNAs), are significant in a number of biological stages and illnesses. The myocardial infarction associated transcript (MIAT) serves a function in numerous types of illness and physiological and pathological processes, including paranoid schizophrenia, diabetic retinopathy, myocardial infarction and neuroendocrine prostate cancer. However, the function of the lncRNA MIAT in the development of osteosarcoma is unknown. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9671
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http://dx.doi.org/10.3892/ol.2018.9671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6312950PMC
January 2019
4 Reads
0.987 Impact Factor

Guanfacine Augmentation of a Combined Intervention of Computerized Cognitive Remediation Therapy and Social Skills Training for Schizotypal Personality Disorder.

Am J Psychiatry 2019 Jan 18:appiajp201818030349. Epub 2019 Jan 18.

Department of Psychiatry, Mt. Sinai School of Medicine, New York (McClure, Perez-Rodriguez, Rosell, Koenigsberg, Hazlett, Siever, New); Department of Psychology, Fairfield University, Fairfield, Conn. (McClure); War Related Illness and Injury Study Center, VA New Jersey Health Care System, East Orange (Graff); Department of Veterans Affairs, VISN2 Mental Illness Research, Education, and Clinical Center, Bronx, N.Y. (Triebwasser, Koenigsberg, Hazlett, Siever); Department of Psychiatry, University of Miami Miller School of Medicine, Miami (Harvey).

Objective:: Impaired cognition is a hallmark of schizophrenia spectrum disorders, including schizotypal personality disorder, and it is the best predictor of functional outcome. Cognitive remediation therapy has demonstrated efficacy for improving cognition, augmenting other rehabilitation efforts in schizophrenia, and effecting gains in real-world functioning. Pharmacological augmentation of cognitive remediation has been attempted, but the effects of augmentation on combined therapies, such as cognitive remediation and social skills training, have not been studied. Read More

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18
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http://dx.doi.org/10.1176/appi.ajp.2018.18030349DOI Listing
January 2019
5 Reads

Modelling and forecasting Positive and Negative Syndrome Scale scores to achieve remission using time series analysis.

Int J Methods Psychiatr Res 2019 Jan 16:e1763. Epub 2019 Jan 16.

Department of Psychiatry & Drug Deaddiction Centre, Lady Hardinge Medical College & Smt. S.K. Hospital, New Delhi, India.

Objectives: Schizophrenia is a chronic mental condition. The objective of this study is to apply time series modelling to Positive and Negative Syndrome Scale scores of outpatients with schizophrenia, observed at regular intervals of time, and hence forecast the number of visits required to reach remission.

Methods: A retrospective data of outpatients diagnosed with chronic paranoid-type schizophrenia were extracted from the records of outpatient department of a tertiary hospital in New Delhi, India. Read More

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http://doi.wiley.com/10.1002/mpr.1763
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http://dx.doi.org/10.1002/mpr.1763DOI Listing
January 2019
5 Reads

Therapeutic Particularities with Depot Medications in Schizophrenia.

Curr Health Sci J 2018 Jul-Sep;44(3):322-325. Epub 2018 Jul 15.

Department of Psychiatry, Clinical Hospital of Neuropsychiatry Craiova.

Schizophrenia is a neurodegenerative disease with personality degradation, changes in behavior, cognition, affective disorder and reduced socio-professional insertion. Early diagnosis is necessary and maintenance is ensured by antipsychotic treatment and for non-compliant patients there is an alternative to depot medication that greatly improves therapeutic adherence. The study presents the case of a 43-year-old patient diagnosed with paranoid schizophrenia using the Diagnostic and Statistical Manual of Mental Disorders V-TR criteria that showed a favorable evolution under depot treatment. Read More

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http://dx.doi.org/10.12865/CHSJ.44.03.19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6311213PMC
July 2018
2 Reads

The contribution of optimism and hallucinations to grandiose delusions in individuals with schizophrenia.

Schizophr Res 2019 Jan 10. Epub 2019 Jan 10.

University Department of Adult Psychiatry, Hospital La Colombière, CHU Montpellier, France; Univ. Paul Valéry Montpellier 3, Univ. Montpellier, EPSYLON EA 4556, F34000, Montpellier, France.

Grandiose delusions (GDs) are defined as false beliefs about having an inflated worth, power, or a special identity which are firmly sustained despite undeniable evidence to the contrary. Although it is the second most commonly encountered delusional beliefs, GDs have received little attention. Thus, in this study, we explored the role of future expectations and sensitivity to reward in GDs in schizophrenia (SZ) disorder. Read More

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http://dx.doi.org/10.1016/j.schres.2018.12.037DOI Listing
January 2019
2 Reads

[Child Protection in Families with Parental Mental Illness].

Prax Kinderpsychol Kinderpsychiatr 2019 Jan;68(1):6-26

Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters der Charité Deutschland Klinik für Psychiatrie, Psychosomatik und Psychotherapie.

Child Protection in Families with Parental Mental Illness Children and adolescents from families with parental mental illness face an increased risk to experience abuse, neglect and maltreatment. The effects of imminent, intermittent or chronic distress on the development of the child and to differentiate these from neglect or maltreatment are not easily assignable in such families. Questionnaires and diagnostic instruments can be supportive tools for professionals in hospitals and private practices to identify and differentiate between burdens of children and families and potential endangerment. Read More

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https://www.vr-elibrary.de/doi/10.13109/prkk.2019.68.1.6
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http://dx.doi.org/10.13109/prkk.2019.68.1.6DOI Listing
January 2019
11 Reads

Haplotypes of TNF/ Genes Associated with Sex-Specific Paranoid Schizophrenic Risk in Tunisian Population.

Dis Markers 2018 5;2018:3502564. Epub 2018 Dec 5.

Laboratory of Genetics, Biodiversity and Bioresource Valorization, Higher Institute of Biotechnology of Monastir, University of Monastir, Monastir, Tunisia.

Several medical research findings have announced a strong association between the biology of cytokines and various brain activities. Since growing evidences suggest the crucial and complex role of the tumor necrosis factor in the CNS, we have hypothesized that functional genetic variants of the LTA and TNFA genes (LTA +252A/G (rs909253) and TNFA -857C/T (rs1799724) and TNFA -238G/A (rs361525)) may be involved in the predisposition to schizophrenia. This research is based on a case-control study. Read More

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http://dx.doi.org/10.1155/2018/3502564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304811PMC
December 2018
1 Read

The expression of toll-like receptors in peripheral blood mononuclear cells is altered in schizophrenia.

Psychiatry Res 2018 Dec 28;272:540-550. Epub 2018 Dec 28.

Department of Experimental Immunology, Medical University of Lodz, Pomorska 251, 92-213, Lodz, Poland. Electronic address:

Increasing evidence suggests that in addition to neurochemical abnormalities, various immunological alterations are related to the pathogenesis of schizophrenia. Toll-like receptors (TLRs) actively mediate immune/inflammatory processes and play a pivotal role in damage/danger recognizing. Therefore, the aim of this study was to compare the expression of TLRs in peripheral blood mononuclear cells (PBMCs) in schizophrenic patients with those of healthy subjects. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.12.138DOI Listing
December 2018
1 Read

[A brief historical approach about the concept of paranoia].

Vertex 2018 Jan;29(137):72-77

Departamento de Psiquiatría, Harvard Medical School, Boston. Centros Lucio Bini para los Trastornos del Ánimo, Cagliari y Roma, Italia. International Consortium for Bipolar & Psychotic Disorders Research, Boston, EE.UU.

From the ancient Greeks (V to III centuries BC), through Hippocrates to the Roman physician Aulo Cornelius Celso (I century), the term paranoia has been used as a manifestation of mental illness. After many centuries, Robert Burton in 1621 introduces the concept with a more modern meaning. Only with Heinroth (1818) the syndrome enters into the psychiatric nosology as a disorder of thought with unaltered perceptions. Read More

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January 2018
1 Read

Choline Compounds of the Frontal Lobe and Temporal Glutamatergic System in Bipolar and Schizophrenia Proton Magnetic Resonance Spectroscopy Study.

Dis Markers 2018 25;2018:3654894. Epub 2018 Nov 25.

Department of Psychiatry, Medical University of Białystok, Plac Brodowicza 1, 16-070 Choroszcz, Poland.

Purpose: Modern neuroimaging techniques allow investigating brain structures and substances involved in the pathophysiology of mental disorders, trying to find new markers of these disorders. To better understanding of the pathophysiology and differential diagnosis of schizophrenia and bipolar disorder, this study was conducted to assess the neurochemical alterations in the frontal and temporal lobes in hospitalized patients with schizophrenia and bipolar disorder.

Methods: Twenty-one subjects with schizophrenia (paranoid and differentiated types), 16 subjects with bipolar I disorder (manic, depressive, and mixed episode), and 20 healthy subjects were studied. Read More

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http://dx.doi.org/10.1155/2018/3654894DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286772PMC
November 2018
1 Read

[The activity of erythrocyte and platelet glutathione reductase and glutathione-S-transferase in paranoid schizophrenia].

Zh Nevrol Psikhiatr Im S S Korsakova 2018 ;118(11):77-81

Mental Health Research Centre, Moscow, Russia.

Aim: A comparative evaluation of glutathione reductase (GR) and glutathione-S-transferase (GST) activities in erythrocytes and platelets of patients with schizophrenia.

Material And Methods: Fifty patients, 47 men and 3 women, aged 25-56 years (medium 34) with acute paranoid schizophrenia (F20.0 ICD-10) with hallucinatory-paranoid or paranoid syndrome were studied. Read More

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http://dx.doi.org/10.17116/jnevro201811811177DOI Listing
January 2018

Exploring the relationship between fantasy proneness and delusional beliefs in psychosis and non-clinical individuals.

Psychiatry Res 2018 Dec 17;272:80-85. Epub 2018 Dec 17.

Centre for Mental Health, Swinburne University of Technology, Hawthorn, VIC, Australia; St Vincent's Mental Health Service, St Vincent's Hospital, Melbourne, VIC, Australia.

Delusions are a core feature of psychopathology while fantasy proneness (FP) is a trait that describes a predisposition towards fantastical thinking, vivid mental imagery and an overactive imagination. The relationship between FP and delusional experiences has not yet been examined in the literature. The current study hypothesised that FP would be significantly associated with and predict delusion severity as well as the associated delusional distress, preoccupation and conviction. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.12.081DOI Listing
December 2018
1 Read

Mental and behavioral disorders in workers: a study on work leave.

Rev Esc Enferm USP 2018 Dec 13;52:e03396. Epub 2018 Dec 13.

Universidade Federal do Piauí, Departamento de Enfermagem, Teresina, PI, Brasil.

Objective: To analyze workers' cases of work leave caused by mental and behavioral disorders.

Method: A cross-sectional census study conducted between June and July 2017 in which data were used from the National Social Security Institute database, with all workers' records. Data were analyzed by using descriptive statistics and inferential tests. Read More

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http://dx.doi.org/10.1590/S1980-220X2017036403396DOI Listing
December 2018
2 Reads

Maternal Infanticide and Filicide in a Psychiatric Custodial Institution in Hong Kong.

Authors:
D Tang B Siu

East Asian Arch Psychiatry 2018 Dec;28(4):139-143

Department of Forensic Psychiatry, Castle Peak Hospital, Hong Kong.

Objective: The aim of this study was to review the history, legislation, and psychiatric perspective of filicide, to compare the characteristics of mothers who committed neonaticide versus infanticide, and to discuss the infanticide law in Hong Kong.

Methods: Data of mothers remanded to the Siu Lam Psychiatric Centre from 2008 to 2016 for filicide were reviewed, as were data of filicide from the Child Fatality Review Reports published by the Social Welfare Department.

Results: From 2008 to 2016, eight mothers were remanded to Siu Lam Psychiatric Centre for filicide. Read More

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December 2018
1 Read

Improvement in renal prognosis with prompt hemodialysis in hyperosmolar hyperglycemic state-related rhabdomyolysis: A case report.

Medicine (Baltimore) 2018 Dec;97(50):e13647

Division of Endocrinology and Metabolism, Department of Internal Medicine, Chang Gung Memorial Hospital, Chang Gung University, Taoyuan City, Taiwan.

Rationale: Acute kidney injury is common and correctable in patients with a hyperosmolar hyperglycemic state (HHS). Nevertheless, hyperglycemic crisis may also contribute to the development of rhabdomyolysis, which can worsen renal function and lead to high mortality in such patients.

Patient Concerns: Herein, we report a case of hyperosmolar hyperglycemic state-related rhabdomyolysis and acute renal failure with an excellent outcome. Read More

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http://dx.doi.org/10.1097/MD.0000000000013647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6319979PMC
December 2018
1 Read

Disturbances of intentionality in schizophrenia and in depression.

Actas Esp Psiquiatr 2018 Nov 1;46(6):234-41. Epub 2018 Nov 1.

Ph. D., Director of the Department of Psychiatry East of the Faculty of Medicine of the University of Chile.

After defining that fundamental element of psychic life which is intentionality, based on original descriptions by Franz Brentano and Edmund Husserl, the authors try to show the way in which this phenomenon is respectively altered in schizophrenia and in depression. For understanding what occurs with respect to this in schizophrenia it is first necessary to focus on what Husserl calls “the consciousness of the interior or immanent time”. The current of consciousness is not a mere succession of “nows”, but of a process of dynamic self-organization, which begins to be developed as, for example, a lecture or a melody is heard. Read More

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November 2018
3 Reads

Capgras syndrome in substance-induced psychosis.

Ment Illn 2018 Nov 6;10(2):7807. Epub 2018 Nov 6.

University of California Irvine, Orange, CA, USA.

Capgras Syndrome is a subcategory of delusional disorder. People affected by this syndrome believe that a close associate such as a friend or family member has been replaced by an identical imposter. This case report describes a 23-year-old woman with no prior psychiatric history, whom developed Capgras syndrome, via , in the setting of poly-substance use. Read More

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http://dx.doi.org/10.4081/mi.2018.7807DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240921PMC
November 2018

Latent Psychotic Symptom Profiles Amongst People Who Use Methamphetamine: What Do They Tell Us About Existing Diagnostic Categories?

Front Psychiatry 2018 19;9:578. Epub 2018 Nov 19.

St Vincent's Hospital, Fitzroy, VIC, Australia.

The inability to distinguish clearly between methamphetamine-related psychosis and schizophrenia has led to the suggestion that "methamphetamine psychosis" does not represent a distinct diagnostic entity but rather that the drug has triggered a vulnerability to schizophrenia. We tested this possibility by exploring the latent class structure of psychotic symptoms amongst people who use the drug and examining how these latent symptom profiles correspond to a diagnosis of schizophrenia. Latent class analysis was carried out on the lifetime psychotic symptoms of 554 current methamphetamine users, of whom 40 met the DSM-IV criteria for schizophrenia. Read More

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http://dx.doi.org/10.3389/fpsyt.2018.00578DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6262399PMC
November 2018
1 Read

[Psychotic symptoms as a side-effect of omeprazole].

Tijdschr Psychiatr 2018;60(12):834-837

A 12-year-old girl with no psychiatric history developed psychotic symptoms, including formal thought disorder and delusional ideas after omeprazole was initiated. Given the co-occurrence of omeprazole initiation and the start of these symptoms, omeprazole was discontinued and replaced by ranitidine which led to immediate symptom reduction followed by complete remission. Although the proton pump inhibitor (ppi) omeprazole is considered safe and is commonly prescribed, it can cause rare major psychiatric side-effects. Read More

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January 2018
19 Reads

Exploratory comparison of auditory verbal hallucinations and other psychotic symptoms among youth with borderline personality disorder or schizophrenia spectrum disorder.

Early Interv Psychiatry 2018 Nov 28. Epub 2018 Nov 28.

Orygen, The National Centre of Excellence in Youth Mental Health, Melbourne, Victoria, Australia.

Objective: This study explored phenomenological aspects of auditory verbal hallucinations (AVH) and other psychotic symptoms among youth with borderline personality disorder (BPD).

Methods: Sixty-eight outpatients, aged 15 to 25 years, were categorized into three groups according to their primary Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) diagnosis and AVH symptom profile; BPD + AVH (n = 23), schizophrenia spectrum disorder (SZ) + AVH (n = 22) and BPD with no AVH (n = 23).

Results: No differences in AVH were found between BPD + AVH and SZ + AVH. Read More

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http://dx.doi.org/10.1111/eip.12763DOI Listing
November 2018
2 Reads

From Evolutive Paranoia, by August Wimmer (1902): Part 2.

Authors:
Johan Schioldann

Hist Psychiatry 2019 Mar 26;30(1):116-124. Epub 2018 Nov 26.

University of Adelaide, Australia.

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http://journals.sagepub.com/doi/10.1177/0957154X18807632
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http://dx.doi.org/10.1177/0957154X18807632DOI Listing
March 2019
5 Reads

Elevated brain-derived neurotrophic factor (BDNF) serum levels in an acute episode of schizophrenia in polish women: Correlation with clinical and metabolic parameters.

Psychiatry Res 2018 Nov 19;271:89-95. Epub 2018 Nov 19.

Psychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.

Brain-derived neurotrophic factor (BDNF) has been implicated in the pathogenesis of psychiatric disorders. Schizophrenia is associated with metabolic abnormalities and BDNF regulates energy homeostasis and glucose metabolism in peripheral tissues. The aim of this study was to examine serum levels of BDNF in schizophrenic women during 8 weeks of treatment and control group, and its correlation with clinical and metabolic parameters. Read More

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http://dx.doi.org/10.1016/j.psychres.2018.11.041DOI Listing
November 2018
24 Reads

Metacognitive Interpersonal Therapy for Treating Persecutory Delusions in Schizophrenia.

Am J Psychother 2018 Nov 21:appipsychotherapy20180039. Epub 2018 Nov 21.

Center for Metacognitive Interpersonal Therapy, Rome (Salvatore, Buonocore, Ottavi, Popolo, Dimaggio); Humanitas, School of Psychotherapy, Rome (Salvatore, Popolo); Istituto A. T. Beck, School of Cognitive Behavioral Therapy, Rome (Ottavi, Dimaggio).

A persecutory delusion (PD) is a person's false belief that others are focusing their attention on him or her with malevolent intentions, which often results in intense anxiety and significant disruption of daily life. PDs are common in schizophrenia, and many patients with schizophrenia do not respond well to current pharmacological treatments. Therefore, effective psychological treatments are needed. Read More

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http://dx.doi.org/10.1176/appi.psychotherapy.20180039DOI Listing
November 2018
10 Reads

Use of antipsychotic drugs in dermatology.

Clin Dermatol 2018 Nov - Dec;36(6):765-773. Epub 2018 Aug 16.

Department of Medicine, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.

Antipsychotic drugs can be beneficial in dermatology because of their both central nervous system and peripheral effects. All antipsychotic drugs have a central postsynaptic dopamine D2 receptor blocking effect, which underlies their antipsychotic action. The antipsychotic drugs have varying degrees of histamine H1-receptor, cholinergic muscarinic receptor, and α1-adrenergic receptor blocking effects, which can affect cutaneous perception and the autonomic reactivity of the skin and can be potentially beneficial in the management of certain histamine or sympathetically mediated dermatologic manifestations (eg, urticaria, pruritus, hyperhidrosis). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0738081X183017
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http://dx.doi.org/10.1016/j.clindermatol.2018.08.006DOI Listing
August 2018
20 Reads

Hearing loss and incident psychosis in later life: The Health in Men Study (HIMS).

Int J Geriatr Psychiatry 2019 Mar 28;34(3):408-414. Epub 2018 Nov 28.

Medical School, University of Western Australia, Perth, Australia.

Objective: To determine if hearing loss is associated with increased risk of incident psychosis in later life.

Methods: Longitudinal cohort study of a community-representative sample of 38 173 men aged 65 to 85 years at the start of the follow-up period of 18 years. We used the Western Australian Data Linkage System to ascertain the presence of hearing loss and of psychotic disorders according to the International Classification of Diseases (ICD) (versions 8, 9, and 10). Read More

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http://doi.wiley.com/10.1002/gps.5028
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http://dx.doi.org/10.1002/gps.5028DOI Listing
March 2019
9 Reads

The Development of Kraepelin's Mature Diagnostic Concepts of Paranoia (Die Verrücktheit) and Paranoid Dementia Praecox (Dementia Paranoides): A Close Reading of His Textbooks From 1887 to 1899.

JAMA Psychiatry 2018 Dec;75(12):1280-1288

Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond.

Over 12 years (1887-1899), in his second through sixth editions of his textbook Psychiatrie: Ein Lehrbuch für Studierende und Ärzte, Emil Kraepelin created, through an iterative, self-examining process, his mature concepts of Verrücktheit (paranoia) and Paranoide Formen Dementia Praecox. I seek in this essay to show this skilled nosologist at work. Four themes were prominent. Read More

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http://dx.doi.org/10.1001/jamapsychiatry.2018.2377DOI Listing
December 2018
1 Read

From Evolutive Paranoia, by August Wimmer (1902).

Hist Psychiatry 2018 Dec;29(4):478-495

University of Adelaide, Australia.

Literature on the history of 'paranoia' (as a clinical concept) is large and confusing. This is partly explained by the fact that over the centuries the word 'paranoia' has been made to participate in several convergences (clinical constructs), and hence it has named different forms of behaviour and been linked to different explanatory concepts. The Classic Text that follows provides information on the internal clinical evolution of the last convergence in which 'paranoia' was made to participate. Read More

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http://journals.sagepub.com/doi/10.1177/0957154X18789598
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http://dx.doi.org/10.1177/0957154X18789598DOI Listing
December 2018
7 Reads

Prediction of prodromal symptoms and schizophrenia-spectrum personality disorder traits by positive and negative schizotypy: A 3-year prospective study.

PLoS One 2018 8;13(11):e0207150. Epub 2018 Nov 8.

Departament de Psicologia Clínica i de la Salut, Universitat Autònoma de Barcelona, Barcelona, Spain.

The present study extends previous cross-sectional findings by examining the predictive validity of positive and negative schizotypy in a young adult sample at a three-year follow-up. Schizotypy and schizophrenia share a comparable multidimensional structure with positive and negative dimensions being the most strongly supported factors. Previous cross-sectional and longitudinal studies employing the psychometric high-risk strategy indicated that schizotypy is a useful method for identifying risk and resilience factors for the development of schizophrenia-spectrum psychopathology. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0207150PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224105PMC
November 2018
14 Reads

Cognition and functionality in delusional disorder.

Eur Psychiatry 2019 01 30;55:52-60. Epub 2018 Oct 30.

Department of Psychiatry, Hospital General Universitario Gregorio Marañón, IiSGM, CIBERSAM, School of Medicine, Universidad Complutense, Calle Ibiza, 43, 28009, Madrid, Spain.

Background: Even if neurocognition is known to affect functional outcomes in schizophrenia, no previous study has explored the impact of cognition on functionality in delusional disorder (DD). We aimed to assess the effect of clinical characteristics, symptom dimensions and neuropsychological performance on psychosocial functioning and self-perceived functional impairment in DD.

Methods: Seventy-five patients with a SCID-I confirmed diagnosis of DD underwent neurocognitive testing using a neuropsychological battery examining verbal memory, attention, working memory and executive functions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09249338183018
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http://dx.doi.org/10.1016/j.eurpsy.2018.09.010DOI Listing
January 2019
3 Reads

First episode psychosis and comorbid ADHD, autism and intellectual disability.

Eur Psychiatry 2019 01 29;55:18-22. Epub 2018 Oct 29.

Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.

Background: Comorbidity between neurodevelopmental disorders and psychotic disorders is common, but little is known about how neurodevelopmental disorders influence the presentation and outcome of first episode psychosis.

Methods: A nation-wide cohort (n = 2091) with a first hospitalization for psychosis between 2007-2011 and at ages between 16-25 at intake was identified from Swedish population registries. Comorbid diagnoses of neurodevelopmental disorders were identified at first psychosis hospitalization and for ADHD also by dispensations of psychostimulants before the first psychosis hospitalization. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09249338183018
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http://dx.doi.org/10.1016/j.eurpsy.2018.09.007DOI Listing
January 2019
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Individualized Metacognitive Training (MCT+) Reduces Delusional Symptoms in Psychosis: A Randomized Clinical Trial.

Schizophr Bull 2019 Jan;45(1):27-36

Discipline of Psychiatry, University of Adelaide, Adelaide, Australia.

Individualized metacognitive training (MCT+) is a novel psychotherapy that has been designed to specifically target delusional beliefs in people with psychosis. It works by developing an awareness of the implausible content of delusional beliefs, while also targeting the cognitive biases that contribute to their formation and maintenance. It was expected that MCT+ would lead to significantly greater reductions in delusional severity compared to a cognitive remediation (CR) active control condition. Read More

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https://academic.oup.com/schizophreniabulletin/advance-artic
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http://dx.doi.org/10.1093/schbul/sby152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293215PMC
January 2019
3 Reads

Violence Associated with Somatic Delusions.

Cureus 2018 Aug 22;10(8):e3186. Epub 2018 Aug 22.

Psychiatry, Maimonides Medical Center, New York, USA.

The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) characterizes delusional disorder (DD) by the presence of delusions for longer than one month, without bizarre behavior or functional impairment. According to Kaplan and Saddock, the lifetime prevalence of DD (all subtypes) is about 0.2%. Read More

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http://dx.doi.org/10.7759/cureus.3186DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199142PMC
August 2018
2 Reads

Association Studies of HSPA1A and HSPA1L Gene Polymorphisms With Schizophrenia.

Arch Med Res 2018 Jul 17;49(5):342-349. Epub 2018 Oct 17.

Department of Medical Genetics, School of Pharmacy with the Division of Laboratory Medicine, Medical University of Silesia, Jednosci 8, 41-200 Sosnowiec, Poland.

Background: Schizophrenia is a severe psychiatric disorder with a strong genetic component. The HSP70 chaperones are particularly interesting in terms of schizophrenia, especially with regard to neurodevelopmental hypothesis, because they are critical regulators in normal neural physiological function as well as in cell stress responses.

Aim Of The Study: The present study aimed to determine whether genetic variants in the HSPA1A (rs1008438, rs562047) and HSPA1L (rs2075800) genes are associated with the risk of paranoid schizophrenia and the clinical presentation of the disease. Read More

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http://dx.doi.org/10.1016/j.arcmed.2018.10.002DOI Listing
July 2018
6 Reads

Refractory Delusional Parasitosis in a 70-year-old Woman.

Cureus 2018 Aug 8;10(8):e3120. Epub 2018 Aug 8.

Psychiatry, West Virginia School of Osteopathic Medicine, Martinsburg, USA.

This is a case report of delusional parasitosis in a 70-year-old woman. Delusional parasitosis, or delusional infestation, is a rare disorder typified by the false belief that an individual is infected with insects or parasites. Management focuses on developing a strong, caring relationship with the patient. Read More

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https://www.cureus.com/articles/13071-refractory-delusional-
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http://dx.doi.org/10.7759/cureus.3120DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6175203PMC
August 2018
14 Reads

Shared psychotic disorder in children and young people: a systematic review.

Eur Child Adolesc Psychiatry 2018 Oct 17. Epub 2018 Oct 17.

Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

This study aimed at searching the literature and reassessing the concept of shared psychotic disorder (SPD) in young people under 18 taking into account genetic vulnerability, social circumstances and family situation to have a better understanding of this condition. Published case reports from 1980 through to March 2017, which included children and adolescents meeting DSM-III/IV/IV-TR or ICD 10 criteria of SPD, were identified. Sociodemographic and clinical variables were collected and analysed; a post hoc analysis comparing inductors and induced was also conducted. Read More

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http://link.springer.com/10.1007/s00787-018-1236-7
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http://dx.doi.org/10.1007/s00787-018-1236-7DOI Listing
October 2018
11 Reads

Lipid profile in schizophrenia: case control study.

Tunis Med 2018 Jan;96(1):22-29

Introduction: Cardiovascular diseases are common co morbidities of schizophrenia and constitute the main factors of high mortality in this pathology. Cardiovascular damages are favored by some risk factors, of which one of the most important is dyslipidemia. In this context, a study of lipid profile in schizophrenia is interesting. Read More

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January 2018
17 Reads

[Paranoid personality disorder and criminal offense].

Authors:
M Bouthier V Mahé

Encephale 2018 Oct 8. Epub 2018 Oct 8.

CHG de Meaux, grand hôpital de l'Est Francilien, site de Meaux, pôle de psychiatrie et addictologie, 6-8, rue Saint-Fiacre, 77100 Meaux, France. Electronic address:

Background: Currently, all of the studies that focus on the relationship between paranoia and criminal offenses exclusively concern subjects suffering from a delusional paranoid disorder. However, subjects with single paranoid personality disorder, without any associated delusional disorder, are not uncommon in forensic practice.

Objectives: This study aims to describe the offenses committed by subjects suffering from a single paranoid personality disorder and to compare them with the offenses committed by the subjects affected by a paranoid delusional disorder associated with paranoid personality disorder. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00137006183016
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http://dx.doi.org/10.1016/j.encep.2018.07.005DOI Listing
October 2018
10 Reads

Unusual high blood glucose in ketoacidosis as first presentation of type 1 diabetes mellitus

Endocrinol Diabetes Metab Case Rep 2018 Sep 25;2018. Epub 2018 Sep 25.

Division of Endocrinology, Diabetology, Vascular Medicine, Nephrology and Clinical Chemistry, Department of Internal Medicine, University of Tübingen, Tübingen, Germany

Diabetic ketoacidosis is a life-threatening complication of diabetes mellitus. It usually occurs in patients with type 1 diabetes where it is typically associated with only moderately increased blood glucose. Here, we report the case of a 52-year-old female patient who was admitted to the emergency unit with severely altered mental status but stable vital signs. Read More

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https://edm.bioscientifica.com/view/journals/edm/2018/1/EDM1
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http://dx.doi.org/10.1530/EDM-18-0094DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6169544PMC
September 2018
5 Reads

Psychological Support for Personality (PSP) versus treatment as usual: study protocol for a feasibility randomized controlled trial of a low intensity intervention for people with personality disorder.

Trials 2018 Oct 10;19(1):547. Epub 2018 Oct 10.

Personality Disorder Research Unit, Centre for Psychiatry, Imperial College London, London, UK.

Background: Previous research has demonstrated the clinical effectiveness of long-term psychological treatment for people with some types of personality disorder. However, the high intensity and cost of these interventions limit their availability. Lower-intensity interventions are increasingly being offered to people with personality disorder, but their clinical and cost effectiveness have not been properly tested in experimental studies. Read More

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http://dx.doi.org/10.1186/s13063-018-2920-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180621PMC
October 2018
5 Reads