Search Our Scientific Publications & Authors

J Cachexia Sarcopenia Muscle 2022 02 5;13(1):532-543. Epub 2021 Dec 5.

Human Genetics Department, Leiden University Medical Center, Leiden, The Netherlands.

Background: Degeneration of shoulder muscle tissues often result in tearing, causing pain, disability and loss of independence. Differential muscle involvement patterns have been reported in tears of shoulder muscles, yet the molecules involved in this pathology are poorly understood. The spatial distribution of biomolecules across the affected tissue can be accurately obtained with matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). Read More

J Shoulder Elbow Surg 2021 Nov 18;30(11):2629-2637. Epub 2021 May 18.

Department of Orthopedics and Rehabilitation, University of Iowa, Iowa City, IA, USA. Electronic address:

Background: Repair of the subscapularis following reverse shoulder arthroplasty (RSA) remains a controversial topic among surgeons. Poor rotator cuff muscle quality is associated with increased musculotendinous stiffness, and the subsequent effect of compromised tissue repair on RSA functional outcomes remains unclear. The objective was to investigate the influence of subscapularis stiffness together with glenoid component lateralization on pre- and postimpingement joint mechanics during external rotation after RSA. Read More

J Shoulder Elbow Surg 2021 Jun 29;30(6):e261-e275. Epub 2020 Sep 29.

Department of Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Department of Neurology, Odense University Hospital, Odense, Denmark; BRIDGE (Brain Research - Inter-Disciplinary Guided Excellence), University of Southern Denmark, Odense, Denmark.

Background: Rotator cuff (RC) disorders involve a spectrum of shoulder conditions from early tendinopathy to full-thickness tears leading to impaired shoulder function and pain. The pathology of RC disorder is, nonetheless, still largely unknown. Our hypothesis is that a supraspinatus (SS) tendon tear leads to sustained inflammatory changes of the SS muscle along with fatty infiltration and muscle degeneration, which are threshold markers for poor RC muscle function. Read More

Cureus 2020 Aug 24;12(8):e10000. Epub 2020 Aug 24.

Pathology, Mount Sinai Hospital, New York, USA.

Dermatomyositis sine dermatitis (DMSD) is a rare autoimmune disease. It's distinguished from classical dermatomyositis (DM) by a lack of skin involvement. DM is known to have a variety of extramuscular manifestations, including interstitial lung disease, myocarditis, and dysphagia. Read More

Yeungnam Univ J Med 2021 Jan 31;38(1):19-26. Epub 2020 Aug 31.

Department of Rehabilitation Medicine, Keimyung University Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Adhesive capsulitis of the shoulder joint is a common disease characterized by pain at the insertional area of the deltoid muscle and decreased range of motion. The pathophysiological process involves fibrous inflammation of the capsule and intraarticular adhesion of synovial folds leading to capsular thickening and contracture. Regarding the multidirectional limitation of motion, a limitation in external rotation is especially prominent, which is related to not only global fibrosis but also to a localized tightness of the anterior capsule. Read More

J Clin Orthop Trauma 2020 Jul 4;11(Suppl 4):S681-S683. Epub 2019 Sep 4.

Ward of Orthopaedics and Traumatology of the Hospital ASST Bergamo Est, Via Paderno 21, 24068, Seriate, Bergamo, Italy.

Paralabral cysts of the shoulder are a rare cause of shoulder pain. Their association with neurological symptoms is uncommon. This case report presents an antero-inferior paralabral cyst in a painful atraumatic shoulder causing axillary and musculocutaneous nerve palsy. Read More

Am J Sports Med 2020 09 30;48(11):2660-2668. Epub 2020 Jul 30.

San Francisco Veteran Affairs Health Care System, San Francisco, California, USA.

Background: The muscle quality of the rotator cuff (RC), measured by atrophy and fatty infiltration (FI), is a key determinant of outcomes in RC injury and repair. The ability to regenerate muscle after repair has been shown to be limited.

Purpose: To determine if there is a source of resident endogenous stem cells, fibroadipogenic progenitor cells (FAPs), within RC injury patients, and if these cells are capable of adipogenic, fibrogenic, and pro-myogenic differentiation. Read More

J Am Acad Dermatol 2021 Apr 8;84(4):e191-e192. Epub 2019 Oct 8.

O'Donoghue Dermatology, Sarasota, Florida. Electronic address:

J Orthop Surg Res 2019 Jun 25;14(1):190. Epub 2019 Jun 25.

Department of Orthopedic Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, South Korea.

Background: A common complication after rotator cuff repair is postoperative stiffness, which can be reduced by a simple application of an anti-adhesive agent. However, anti-adhesive agents may affect rotator cuff healing by preventing fibrosis. This experimental animal study evaluated the effect of the application of a poloxamer-based thermosensitive anti-adhesive gel and its influence on the healing of an acute rotator cuff repair in a rabbit model. Read More

J Orthop Surg Res 2018 Nov 29;13(1):304. Epub 2018 Nov 29.

Department of Orthopaedics, University of Zurich, Balgrist University Hospital, Forchstrasse 340, CH-8008, Zürich, Switzerland.

Background: The anterior deltopectoral approach is the standard approach for performing the open Latarjet procedure. Through the use of a more medial and vertical skin incision, the scar can be cosmetically covered by the bra strap in women. We call this incision the bra strap incision. Read More

J Pharmacopuncture 2017 Sep 30;20(3):227-229. Epub 2017 Sep 30.

Health Science Unit (PEC), Hong Kong Physically Handicapped & Able Bodied Association, Kowloon, Hong Kong.

Fibrosis of skeletal muscle following acupuncture is an iatrogenic disorder. The present case illustrates a patient with a unilateral fibrotic formation on a thumb muscle after acupuncture injection therapy with red sage. The patient in the present case was a counter-terrorism police officer with right-handedness; he noted a palpable nodule three months after injection therapy at his left first dorsal interosseous in which the acupuncture point LI4 (He Gu) is located. Read More

J Anat 2018 10 24;233(4):552-556. Epub 2018 Jul 24.

Department of Neuroscience, University of Padua, Padua, Italy.

Recently, alterations in fascial gliding-like movement have been invoked as critical in the etiology of myofascial pain. Various methods have been attempted for the relief of this major and debilitating clinical problem. Paramount have been attempts to restore correct gliding between fascial layers and the movement over bone, joint, and muscular structures. Read More

J Hand Surg Eur Vol 2018 Jul 12;43(6):589-595. Epub 2018 Feb 12.

5 Clinique du Mont Louis, Paris, France.

Spinal accessory nerve grafting requires identification of both nerve stumps in the scar tissue, which is sometimes difficult. We propose a direct nerve transfer using a fascicle from the posterior division of the upper trunk. We retrospectively reviewed 11 patients with trapezius palsy due to an iatrogenic injury of the spinal accessory nerve in nine cases. Read More

Medicine (Baltimore) 2017 Dec;96(51):e9373

Department of Plastic Surgery, Peking Union Medical College Hospital Department of Plastic Surgery, China Meitan General Hospital, Beijing, China.

Rationale: In this study, a case of toe keloid after nail extraction is presented, in which the keloids on both toes were resected by surgical excision. Keloids (from the Greek word meaning "crab's claw") are fibrous growths that extend beyond the original area of injury to involve the adjacent normal skin. In general, keloid tendencies appear to be regionally isolated to keloid-prone areas, such as the chest, ears, and deltoid regions, whereas the hands and feet are usually spared, which is why this case is meaningful. Read More

Front Neurol 2017 31;8:367. Epub 2017 Jul 31.

Human Stem Cells Institute, Moscow, Russia.

Plectinopathies are orphan diseases caused by gene mutations. is encoding the protein plectin, playing a role in linking cytoskeleton components in various tissues. In this study, we describe the clinical case of a 26-year-old patient with an early onset plectinopathy variant "limb-girdle muscle dystrophy type 2Q," report histopathological and ultrastructural findings in m. Read More

Eur J Orthop Surg Traumatol 2017 Apr 14;27(3):391-397. Epub 2017 Mar 14.

Orthopaedic and Trauma Department, Rouen University Hospital, 1, rue de Germont, 76000, Rouen, France.

Open reduction and internal fixation of complex proximal humeral fracture represents a surgical challenge. The main objective of this procedure is to anatomically reduce the tuberosities. We propose a standardized and reproducible technique that we apply to all complex displaced 3- and 4-part fractures of patients under 50 years. Read More

J Plast Reconstr Aesthet Surg 2016 Dec 23;69(12):1653-1661. Epub 2016 Sep 23.

Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, China.

Background: The anterior chest is an excellent donor site for cervicofacial reconstruction. Studies of chest flaps began as early as 1988 at our institution. We identified a new branch of the supraclavicular artery that nourishes the anterior chest, and on the basis of this finding, we created a new flap called the subclavicular flap. Read More

PLoS One 2016;11(9):e0162494. Epub 2016 Sep 26.

Department of Biological Sciences, Faculty of Science, University of Manitoba, Winnipeg, MB, Canada.

Background: Rotator-cuff injury (RCI) is common and painful; even after surgery, joint stability and function may not recover. Relative contributions to atrophy from disuse, fibrosis, denervation, and satellite-cell responsiveness to activating stimuli are not known.

Methods And Findings: Potential contributions of denervation and disrupted satellite cell responses to growth signals were examined in supraspinatus (SS) and control (ipsilateral deltoid) muscles biopsied from participants with RCI (N = 27). Read More

Muscle Nerve 2017 05 11;55(5):715-726. Epub 2017 Jan 11.

Department of Biological Sciences, Faculty of Science, University of Manitoba, 212 Biological Sciences Building, 50 Sifton Road, Winnipeg, MB, R3T 2N2, Canada.

Introduction: Rotator-cuff injury (RCI) represents 50% of shoulder injuries, and prevalence increases with age. Even with successful tendon repair, muscle and joint function may not return.

Methods: To explore the dysfunction, supraspinatus and ipsilateral deltoid (control) muscles were biopsied during arthroscopic RCI repair for pair-wise histological and protein-expression studies. Read More

Front Aging Neurosci 2015 22;7:236. Epub 2015 Dec 22.

Department of Human Genetics, Leiden University Medical Center Leiden, Netherlands.

Shoulder complaints are common in the elderly and hamper daily functioning. These complaints are often caused by tears in the muscle-tendon units of the rotator cuff (RC). The four RC muscles stabilize the shoulder joint. Read More

J Craniofac Surg 2015 Jun;26(4):1355-7

*Buleun Health Care Center, Incheon, Republic of Korea †Keloid Research Foundation, New York, NY ‡Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.

Background: Until now, clinical studies dealing with pediatric keloids are extremely rare considering widespread controversies over the mode of inheritance of keloids. To the best of the authors' knowledge, there have been no reports analyzing this condition systemically. The purpose of this study was to summarize the baseline characteristics of a cohort of pediatric patients and recommend our effective regimens. Read More

J Craniofac Surg 2015 Jan;26(1):e48-50

From the *Department of Plastic Surgery, Inha University School of Medicine, Incheon; †Department of Anatomy, College of Medicine, Chung-Ang University, Seoul; and ‡Inha Research Institute for Medical Science, Incheon, Korea.

The aim of this study was to compare the skin tension of several fascial/subcutaneous tensile reduction sutures. Six upper limbs and 8 lower limbs of 4 fresh cadavers were used. At the deltoid area (10 cm below the palpable acromion) and lateral thigh (midpoint from the palpable greater trochanter to the lateral border of the patella), and within a 3 × 6-cm fusiform area of skin, subcutaneous tissue defects were created. Read More

Ann Plast Surg 2014 Sep;73 Suppl 1:S53-6

From the Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Shaanxi, China.

Purpose: Cervical scar contracture causes both physical and psychological distress for burn patients. Many pedicle flaps or skin grafting have been suggested for reconstruction of cervical scar contracture with variable results in the literature. The authors present the axial thoracic flap based on the thoracic branch of the supraclavicular artery (TBSA) for reconstruction of cervical scar contracture. Read More

BMC Musculoskelet Disord 2014 Jun 16;15:206. Epub 2014 Jun 16.

Department of Orthopedics, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China.

Background: The use of minimally invasive plate osteosynthesis (MIPO) via anterolateral deltoid splitting has good outcomes in the management of proximal humerus fractures. While using this approach has several advantages, including minimal soft tissue disruption, preservation of natural biology and minimal blood loss, there is an increased risk for axillary nerve damage. This study compared the advantages and clinical and radiological outcomes of MIPO or open reduction and internal fixation (ORIF) in patients with proximal humerus fractures. Read More

Ann Plast Surg 2015 Feb;74(2):248-51

From the *Department of Plastic and Reconstructive Surgery, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea; †Keloid Research Foundation, New York, NY; and ‡Reconstructive Sciences Unit, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia.

Background: There is strong evidence of genetic susceptibility in individuals with keloid disorder. The purpose of this cross-sectional study was to determine the clinical relevance of our proposed variables on the multiplicity of keloids by further investigating the presence of other keloids and a family history.

Methods: This was a retrospective review, using institutional review board-approved questionnaires, of patients with keloids who were seen at Kangbuk Samsung Hospital between December 2002 and February 2010. Read More

J Clin Diagn Res 2013 Feb 1;7(2):371-3. Epub 2013 Feb 1.

Professor, Department of Orthopaedics, Konaseema Institute of Medical Scienes , Amalapuram, Andhra Pradesh, India .

Post injection fibrosis leading to muscle contracture is a known complication. Deltoid fibrosis is known to occur following trauma or an intramuscular injection. Idiopathic Deltoid fibrosis leading to abduction contracture and anterior dislocation of the shoulder is a rare entity. Read More

J Neuropathol Exp Neurol 2013 Mar;72(3):234-43

UPMC Université Pierre et Marie Curie, Institut de Myologie, Paris, France.

Oculopharyngeal muscular dystrophy (OPMD) is a late-onset autosomal dominant inherited dystrophy caused by an abnormal trinucleotide repeat expansion in the poly(A)-binding-protein-nuclear 1 (PABPN1) gene. Primary muscular targets of OPMD are the eyelid elevator and pharyngeal muscles, including the cricopharyngeal muscle (CPM), the progressive involution of which leads to ptosis and dysphagia, respectively. To understand the consequences of PABPN1 polyalanine expansion in OPMD, we studied muscle biopsies from 14 OPMD patients, 3 inclusion body myositis patients, and 9 healthy controls. Read More

Rinsho Shinkeigaku 2013 ;53(1):41-5

Department of Neurology, Kyoto Prefectural University of Medicine, Graduate School of Medicine.

We report an 87-year-old female patient who presented a dropped head and progressive weakness in proximal muscles over five months. The value of serum creatine kinase was 2,708 IU/l and the antibody against signal recognition particle (SRP) was detected by means of immunoprecipitation. The computed tomography of skeletal muscles revealed atrophy and fatty degeneration preferentially in the neck extensors and paraspinal muscles. Read More

Zhonghua Shao Shang Za Zhi 2012 Aug;28(4):256-9

Institute of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China.

Objective: To observe the therapeutic effect of repairing cervical scar contracture using flaps carrying cervical cutaneous branch of the transverse cervical artery.

Methods: Sixty-six patients with scar contracture after burn in anterior region of neck hospitalized from 1988 to 2011. The scars were excised and repaired with flaps containing the cervical cutaneous branch of transverse cervical artery. Read More

Lasers Med Sci 2013 May 21;28(3):957-64. Epub 2012 Aug 21.

Department of Orthopedic, Traumatologic, Rehabilitative and Plastic-Reconstructive Sciences, Second University of Naples, Naples, Italy.

Keloids and hypertrophic scars are abnormal responses to wound healing. In general, keloids exhibit a proliferative growth beyond the margins of the scar and remain persistent; while hypertrophic scars are contained to the original wound and may regress over time. In particular, keloid formation is one of the most challenging clinical problems, with increasing frequency in surgical practice. Read More