19,561 results match your criteria Delaware medical journal[Journal]


Transcriptomic Characterization of Bacteroids Reveals a Post-Symbiotic, Hemibiotrophic-Like Lifestyle of the Bacteria within Senescing Soybean Nodules.

Int J Mol Sci 2018 Dec 7;19(12). Epub 2018 Dec 7.

Division of Biochemistry, University of Missouri, Columbia, MO 65211, USA.

The transcriptional activity of isolated from soybean nodules was monitored over the period from symbiosis to late plant nodule senescence. The bacteria retained a near constant level of RNA throughout this period, and the variation in genes demonstrating increased, decreased, and/or patterned transcriptional activity indicates that the bacteria are responding to the changing environment within the nodule as the plant cells progress from an organized cellular structure to an unorganized state of internal decay. The transcriptional variation and persistence of the bacteria suggest that the bacteria are adapting to their environment and acting similar to hemibiotrophs, which survive both as saprophytes on live plant tissues and then as necrophytes on decaying plant tissues. Read More

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December 2018

Healthcare Providers' Perceived Communication Barriers to Offering Palliative Care to Patients With Heart Failure: An Integrative Review.

J Cardiovasc Nurs 2018 Dec 11. Epub 2018 Dec 11.

Marianne K. Schallmo, DNP, ANP-BC Clinical Assistant Professor of Nursing, School of Nursing, Purdue University Northwest, Hammond, Indiana. Sharon Dudley-Brown, PhD, FNP-BC, FAAN Associate Professor of Nursing, School of Nursing, University of Delaware, Newark. Patricia M. Davidson, PhD, MEd, BA, FAAN Dean of Nursing, School of Nursing, Johns Hopkins University, Baltimore, Maryland.

Context: Heart failure is a chronic complex syndrome that is common and burdensome. International clinical practice guidelines recommend that healthcare providers communicate palliative care options with patients with heart failure.

Objectives: The aim of this study was to conduct an integrative review to evaluate how healthcare providers perceived communication barriers to offering information to individuals in the palliative phase of heart failure. Read More

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December 2018

The Incidence and Nature of Allergic and Anaphylactic Reactions During Pediatric Procedural Sedation: A Report From the Pediatric Sedation Research Consortium.

Hosp Pediatr 2018 Dec 12. Epub 2018 Dec 12.

Department of Pediatrics, Herman and Walter Samuelson Children's Hospital at Sinai, Baltimore, Maryland.

Background And Objectives: Anaphylaxis is rare but life-threatening. Its incidence during pediatric procedural sedation outside of the operating room is unknown. We used data from the Pediatric Sedation Research Consortium (PSRC) to determine the incidence and nature of allergic and anaphylactic reactions in this practice. Read More

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December 2018

Reducing Tracheostomy-Related Pressure Injuries.

AACN Adv Crit Care 2018 ;29(4):426-431

Lois M. Dixon is Wound Ostomy Continence Clinical Leader, Christiana Care Health System, 4755 Ogletown-Stanton Road, Newark, DE 19718 Susan Mascioli is Director, Nursing Quality and Safety, Christiana Care Health System, Newark, Delaware. Jefferson H. Mixel is Clinical Manager, Department of Respiratory Care, Christiana Care Health System, Newark, Delaware. Tom Gillin is Critical Care Coordinator, Department of Respiratory Care, Christiana Care Health System, Newark, Delaware. Camille N. Upchurch is Physician, Christiana Care Hospitalist Partners, Christiana Care Health System, Newark, Delaware. Kevin M. Bradley is Medical Director of the Trauma Program, Christiana Care Health System, Newark, Delaware.

An interprofessional team was established to prevent tracheostomy-related acquired pressure injuries. The team performed an in-depth analysis of practice from tracheostomy insertion through postinsertion care. A literature evaluation identified best practices, and a root cause analysis for all tracheostomy-related pressure injury cases identified common causes. Read More

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January 2018

Acute Respiratory Distress Syndrome and Prone Positioning.

AACN Adv Crit Care 2018 ;29(4):415-425

Dannette A. Mitchell is Critical Care Clinical Nurse Specialist, Christiana Care Health Service, Wilmington Hospital, 501 W 14th Street, Intensive Care and Transitional Care Unit - 6S45, Wilmington, DE 19801 Maureen A. Seckel is Lead Critical Care Clinical Nurse Specialist and Sepsis Leader, Christiana Care Health Service, Christiana Hospital, Newark, Delaware.

Acute respiratory distress syndrome continues to have high morbidity and mortality despite more than 50 years of research. The Berlin definition in 2012 established risk stratification based on degree of hypoxemia and the use of positive end-expiratory pressure. The use of prone positioning as a treatment modality has been studied for more than 40 years, with recent studies showing an improvement in oxygenation and decreased mortality. Read More

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January 2018

Transjugular intrahepatic portosystemic shunt (TIPS) placement: A comparison of outcomes between patients with hepatic hydrothorax and patients with refractory ascites.

Diagn Interv Imaging 2018 Dec 3. Epub 2018 Dec 3.

Department of Radiology, University of Minnesota, 420 Delaware St SE, MMC 292, 55455 Minneapolis, USA.

Purpose: To compare the outcomes in patients who had transjugular intrahepatic portosystemic shunts (TIPS) placed for hepatic hydrothorax with those who had it placed for refractory ascites.

Materials And Methods: One hundred and forty-seven patients who underwent TIPS placement for refractory fluid accumulation were included. There were 97 men and 50 women with a mean age of 56. Read More

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December 2018

OMCD: OncomiR Cancer Database.

BMC Cancer 2018 Dec 6;18(1):1223. Epub 2018 Dec 6.

Department of Surgery, University of Minnesota, 11-212 Moos Tower Mayo Mail Code 195 420 Delaware Street SE, Minneapolis, MN, 55455, USA.

Background: microRNAs (miRNAs) are crucially important in the development of cancer. Their dysregulation, commonly observed in various types of cancer, is largely cancer-dependent. Thus, to understand the tumor biology and to develop accurate and sensitive biomarkers, we need to understand pan-cancer miRNA expression. Read More

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December 2018

Single molecule dynamics of the P granule scaffold MEG-3 in the C. elegans zygote.

Mol Biol Cell 2018 Dec 12:mbcE18060402. Epub 2018 Dec 12.

Department of Biological Sciences, Dartmouth College, Hanover NH 03755, USA.

During the asymmetric division of the C. elegans zygote, germ (P) granules are disassembled in the anterior cytoplasm and stabilized/assembled in the posterior cytoplasm, leading to their inheritance by the germline daughter cell. P granule segregation depends on MEG-3 and MEG-4, which are enriched in P granules and in the posterior cytoplasm surrounding P granules. Read More

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December 2018

Effort matching between arms depends on relative limb geometry and personal control.

J Neurophysiol 2018 Dec 12. Epub 2018 Dec 12.

Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary, Canada.

Proprioception encompasses our sense of position and movement of our limbs, as well as the effort with which we engage in voluntary actions. Historically, sense of effort has been linked to centrally generated signals that elicit voluntary movements. We were interested in determining the effect of differences in limb geometry and personal control on sense of effort. Read More

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December 2018

Self-Preferred Initial Position Could Be a Viable Alternative to the Standard Squat Jump Testing Procedure.

J Strength Cond Res 2018 Nov;32(11):3267-3275

Department of Neurophysiology, Institute for Medical Research, University of Belgrade, Belgrade, Serbia.

Petronijevic, MS, Garcia Ramos, A, Mirkov, DM, Jaric, S, Valdevit, Z, and Knezevic, OM. Self-preferred initial position could be a viable alternative to the standard squat jump testing procedure. J Strength Cond Res 32(11): 3267-3275, 2018-The purpose of this study was to compare both the magnitude and reliability of different variables (knee angle, squat depth, jump height [Hmax], maximum force [Fmax], and maximum power [Pmax]) between the standardized squat jump (SJ) and the SJ performed from the self-preferred position. Read More

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November 2018

Optimisation of applied loads when using the two-point method for assessing the force-velocity relationship during vertical jumps.

Sports Biomech 2018 Dec 12:1-16. Epub 2018 Dec 12.

c Department of Kinesiology and Applied Physiology & Biomechanics and Movement Science Graduate Program , University of Delaware , Newark , DE , USA.

This study aimed to compare the reliability and validity of the force-velocity (F-V) relationship parameters obtained from two-point methods differing in the distance between experimental points, and to evaluate the acute change in unloaded jump height after a vertical jump testing procedure based on multiple loads. Totally, 18 men randomly performed two sessions of the squat jump (SJ) and two sessions of the countermovement jump (CMJ) exercises against five external loads (17, 30, 45, 60 and 75 kg). The unloaded jump height was evaluated before and after each testing procedure. Read More

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December 2018
2 Reads

Determining a transitional scoring link between PROMIS® pediatric and adult physical health measures.

Qual Life Res 2018 Dec 11. Epub 2018 Dec 11.

Duke University, Durham, NC, USA.

Purpose: Having independent versions of the PROMIS® scales (for Pediatric and Adults) is problematic as scores cannot be evaluated longitudinally as individuals move from childhood into adulthood. The primary aim of this research project is to use item response theory (IRT) to develop a transitional scoring link (or "crosswalk") between the PROMIS adult and pediatric physical health measures.

Setting: Sample 1 was collected at 6 rehabilitation hospitals in the U. Read More

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December 2018

Inflammation-Nature's Way to Efficiently Respond to All Types of Challenges: Implications for Understanding and Managing "the Epidemic" of Chronic Diseases.

Front Med (Lausanne) 2018 27;5:316. Epub 2018 Nov 27.

School of Medicine and Public Health, Faculty of Health and Medicine, University of Newcastle, Newcastle, NSW, Australia.

Siloed or singular system approach to disease management is common practice, developing out of traditional medical school education. Textbooks of medicine describe a huge number of discrete diseases, usually in a systematic fashion following headings like etiology, pathology, investigations, differential diagnoses, and management. This approach suggests that the body has a multitude of ways to respond to harmful incidences. Read More

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November 2018
1 Read

Chronic Kidney Disease stratification using office visit records: Handling data imbalance via hierarchical meta-classification.

BMC Med Inform Decis Mak 2018 Dec 12;18(Suppl 4):125. Epub 2018 Dec 12.

Computational Biomedicine Lab, Computer and Information Sciences, University of Delaware, Newark, DE, USA.

Background: Chronic Kidney Disease (CKD) is one of several conditions that affect a growing percentage of the US population; the disease is accompanied by multiple co-morbidities, and is hard to diagnose in-and-of itself. In its advanced forms it carries severe outcomes and can lead to death. It is thus important to detect the disease as early as possible, which can help devise effective intervention and treatment plan. Read More

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December 2018

Group Differences Among Caregivers of Civilians and Service Members or Veterans with Traumatic Brain Injury.

Arch Phys Med Rehabil 2018 Dec 8. Epub 2018 Dec 8.

University of Michigan Medical School, Department of Physical Medicine and Rehabilitation, Ann Arbor, Michigan.

Objective: To examine group differences among caregivers of service members/veterans (SMVs) and civilians with traumatic brain injury (TBI).

Design: An observational research study examining the group differences between caregivers of SMVs and civilians with TBI. The data presented was collected as part of a larger study that calibrated and validated the TBI-CareQOL item banks. Read More

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December 2018

Detection of extracellular vesicles in the mouse vaginal fluid: Their delivery of sperm proteins that stimulate capacitation and modulate fertility.

J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.

Department of Biological Sciences, University of Delaware, Newark, Delaware.

Extracellular vesicles (EVs) were isolated by ultracentrifugation of vaginal luminal fluid (VLF) from superovulated mice and identified for the first time using transmission electron microscopy. Characterized by size and biochemical markers (CD9 and HSC70), EVs were shown to be both microvesicular and exosomal and were dubbed as "Vaginosomes" (VGS). Vaginal cross-sections were analyzed to visualize EVs in situ: EVs were present in the lumen and also embedded between squamous epithelial and keratinized cells, consistent with their endogenous origin. Read More

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December 2018

Medulloblastoma and secondary acute myeloid leukemia in a patient with Turner syndrome.

Pediatr Blood Cancer 2018 Dec 10:e27576. Epub 2018 Dec 10.

Division of Hematology/Oncology, Department of Pediatrics, Nemours/A.I duPont Hospital for Children, Thomas Jefferson University, Wilmington, Delaware.

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December 2018
1 Read

Application of the Bacterial Meningitis Score for Infants Aged 0 to 60 Days.

J Pediatric Infect Dis Soc 2018 Dec 10. Epub 2018 Dec 10.

Division of Emergency Medicine, Boston Children's Hospital, Harvard Medical School, Massachusetts.

In 4292 infants aged ≤60 days with cerebrospinal fluid (CSF) pleocytosis, the bacterial meningitis score had excellent sensitivity (121 of 121 [100.0%] [95% confidence interval, 96.5%-100. Read More

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December 2018

Carotid artery blood flow velocities and cognitive performance: forecasting cognitive decline.

Am J Hypertens 2018 Dec 8. Epub 2018 Dec 8.

Department of Behavioral Health and Nutrition, College of Health Sciences, University of Delaware, Newark, DE, USA.

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December 2018

Relationship of Movement Screens with Past Shoulder or Elbow Surgeries in Collegiate Baseball Players.

Int J Sports Phys Ther 2018 Dec;13(6):1008-1014

School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH.

Background: Upper extremity injuries commonly occur in baseball players, and can often necessitate surgical interventions. Athletes recovering from previous surgeries may be at greater risk of a secondary injury due to potential residual deficits in global movement. Identifying individuals with residual movement dysfunction following surgery during a pre-participation examination may help health care professionals identify baseball players who may be at a greater risk of re-injury in their throwing arms so that appropriate interventions can be developed. Read More

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December 2018

ZetaHunter, a Reproducible Taxonomic Classification Tool for Tracking the Ecology of the and Other Poorly Resolved Taxa.

Microbiol Resour Announc 2018 Aug 23;7(7). Epub 2018 Aug 23.

School of Marine Science and Policy, University of Delaware, Newark, Delaware, USA.

Like many taxa, the lack well-defined taxonomic divisions, making it difficult to compare them between studies. We designed ZetaHunter to reproducibly assign 16S rRNA gene sequences to previously described operational taxonomic units (OTUs) based on a curated database. While ZetaHunter can use any given database, we included a curated classification of publicly available . Read More

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Complete Genome Sequence of Vibrio coralliilyticus RE22, a Marine Bacterium Pathogenic toward Larval Shellfish.

Microbiol Resour Announc 2018 Nov 1;7(17). Epub 2018 Nov 1.

U.S. Department of Agriculture, Agricultural Research Service, Eastern Regional Research Center, Wyndmoor, Pennsylvania, USA.

Vibrio coralliilyticus RE22 is an indigenous marine pathogen that infects larval bivalve shellfish. This strain is particularly problematic in oyster hatcheries, where it causes high larval mortality. It contains two circular chromosomes and one megaplasmid. Read More

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November 2018

Complete Genome Sequence of a Wild-Type Isolate of Caulobacter vibrioides Strain CB2.

Microbiol Resour Announc 2018 Nov 1;7(17). Epub 2018 Nov 1.

Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, USA.

The complete genome of Caulobacter vibrioides strain CB2 consists of a 4,123,726-bp chromosome, a GC content of 67.2%, and 3,896 coding DNA sequences. It has no rearrangements but numerous indels relative to the reference NA1000 genome. Read More

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November 2018

Complete Genome Sequence of a Wild-Type Isolate of Caulobacter vibrioides Strain CB1.

Microbiol Resour Announc 2018 Sep 27;7(12). Epub 2018 Sep 27.

Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, USA.

The complete genome sequence of Caulobacter vibrioides strain CB1 consists of a chromosome of 4,137,285 bp, with a GC content of 67.2% and 3,990 coding DNA sequences. This strain contains the typical genome rearrangement that is characteristic of the Caulobacter strains that are currently sequenced. Read More

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September 2018

Multifactorial Origin of Exertional Rhabdomyolysis, Recurrent Hematuria, and Episodic Pain in a Service Member with Sickle Cell Trait.

Case Rep Genet 2018 7;2018:6898546. Epub 2018 Nov 7.

Consortium for Health and Military Performance, Department of Military and Emergency Medicine, Hébert School of Medicine, Uniformed Services University, 4301 Jones Bridge Rd., Bethesda, MD 20184, USA.

Individuals with Sickle Cell Trait (SCT), generally considered a benign carrier state of hemoglobin S (HbAS), are thought to be at risk for exertional rhabdomyolysis and hematuria, conditions that can also be caused by various other acquired and inherited factors. We report an SCT positive service member with an exertional rhabdomyolysis event, recurrent hematuria with transient proteinuria, and episodic burning pain in the lower extremities. Clinical and genetic studies revealed the multifactorial nature of his complex phenotype. Read More

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November 2018

Characterizing changes in glucocorticoid receptor internalization in the fear circuit in an animal model of post traumatic stress disorder.

PLoS One 2018 7;13(12):e0205144. Epub 2018 Dec 7.

Department of Psychological and Brain Sciences, University of Delaware, Newark, DE, United States of America.

Glucocorticoid receptors (GRs) shuttle from the cytoplasm (cy) to the nucleus (nu) when bound with glucocorticoids (i.e. GR internalization) and alter transcriptional activity. Read More

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December 2018

Riboregulated toehold-gated gRNA for programmable CRISPR-Cas9 function.

Nat Chem Biol 2018 Dec 10. Epub 2018 Dec 10.

Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, DE, USA.

Predictable control over gene expression is essential to elicit desired synthetic cellular phenotypes. Although CRISPR-Cas9 offers a simple RNA-guided method for targeted transcriptional control, it lacks the ability to integrate endogenous cellular information for efficient signal processing. Here, we present a new class of riboregulators termed toehold-gated gRNA (thgRNA) by integrating toehold riboswitches into sgRNA scaffolds, and demonstrate their programmability for multiplexed regulation in Escherichia coli with minimal cross-talks. Read More

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December 2018
2 Reads

Deletion of four genes in Escherichia coli enables preferential consumption of xylose and secretion of glucose.

Metab Eng 2018 Dec 7. Epub 2018 Dec 7.

Department of Chemical and Biomolecular Engineering, Metabolic Engineering and Systems Biology Laboratory, University of Delaware, Newark DE 19716, USA. Electronic address:

Overcoming carbon catabolite repression presents a significant challenge, largely due to the complex regulatory networks governing substrate catabolism, even in microbial cells. In this work, we have engineered an E. coli strain, which we have named X2G, that not only exhibits a reversed substrate preference for xylose over glucose, but also demonstrates an unusual ability to produce significant amounts of glucose. Read More

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December 2018

Intrathecal heparan-N-sulfatase in patients with Sanfilippo syndrome type A: A phase IIb randomized trial.

Mol Genet Metab 2018 Oct 24. Epub 2018 Oct 24.

Shire, Lexington, MA, USA. Electronic address:

Background: Sanfilippo syndrome type A (mucopolysaccharidosis type IIIA) is a lysosomal disorder wherein deficient heparan-N-sulfatase (HNS) activity results in the accumulation of heparan sulfate in the central nervous system and is associated with progressive neurodegeneration in early childhood. We report on the efficacy, pharmacokinetics, safety, and tolerability of intrathecal (IT) administration of recombinant human HNS (rhHNS) from a phase IIb randomized open-label trial.

Methods: Twenty-one patients, randomized 1:1:1 to rhHNS IT 45 mg administered every 2 weeks (Q2W), every 4 weeks (Q4W), or no treatment, were assessed for amelioration in neurocognitive decline as determined by the Bayley Scales of Infant and Toddler Development®, Third Edition. Read More

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October 2018

Video screen viewing and first intubation attempt success with standard geometry video laryngoscope use.

Am J Emerg Med 2018 Oct 16. Epub 2018 Oct 16.

Department of Emergency Medicine, Hennepin County Medical Center, 701 Park Avenue, Minneapolis, MN 55415, United States of America; Department of Emergency Medicine, University of Minnesota Medical School, 717 Delaware Street SE, Suite 508, Minneapolis, MN 55414, United States of America. Electronic address:

Study Objectives: Direct laryngoscopy (DL) is the traditional approach for emergency intubation but video laryngoscopy (VL) is gaining popularity. Some studies have demonstrated higher first-attempt success with VL, particularly in difficult airways. In real-world settings, physicians choose whether or not to view the video screen when utilizing VL devices for tracheal intubation. Read More

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October 2018

Stochastic resonance stimulation improves balance in children with cerebral palsy: a case control study.

J Neuroeng Rehabil 2018 Dec 10;15(1):115. Epub 2018 Dec 10.

Department of Kinesiology, University of Delaware, 540 S. College Ave, Newark, DE, 19713, USA.

Background: Stochastic Resonance (SR) Stimulation has been used to enhance balance in populations with sensory deficits by improving the detection and transmission of afferent information. Despite the potential promise of SR in improving postural control, its use in individuals with cerebral palsy (CP) is novel. The objective of this study was to investigate the immediate effects of electrical SR stimulation when applied in the ankle muscles and ligaments on postural stability in children with CP and their typically developing (TD) peers. Read More

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December 2018

Automatic gene annotation using GO terms from cellular component domain.

BMC Med Inform Decis Mak 2018 Dec 7;18(Suppl 5):119. Epub 2018 Dec 7.

Department of Computer and Information Science, University of Delaware, Newark, DE, 19716, USA.

Background: The Gene Ontology (GO) is a resource that supplies information about gene product function using ontologies to represent biological knowledge. These ontologies cover three domains: Cellular Component (CC), Molecular Function (MF), and Biological Process (BP). GO annotation is a process which assigns gene functional information using GO terms to relevant genes in the literature. Read More

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December 2018

Wet-Chemical Synthesis of Surface-Passivated Halide Perovskite Microwires for Improved Optoelectronic Performance and Stability.

ACS Appl Mater Interfaces 2018 Dec 10. Epub 2018 Dec 10.

State Key Laboratory of Solidification Processing, Center for Nano Energy Materials, School of Materials Science and Engineering , Northwestern Polytechnical University and Shaanxi Joint Laboratory of Graphene (NPU) , Xi'an 710072 , P. R. China.

One-dimensional (1D) halide perovskite materials with intrinsic high carrier mobility and long diffusion length hold great promises for high-performance optoelectronic devices, in which the passivation of the surface defects is of significance for further boosting its optoelectronic performance as well as its moisture stability. Herein, we demonstrate a simple room-temperature wet-chemical synthetic protocol for perovskite microwires with controlled morphologies and passivated surface states. This strategy allows for facile assembly of hydrophobic 1 H,1 H-perfluorooctylamine (PFA) molecules on the surface of the perovskite microwires owing to the coordination binding between the amino groups of PFA and Pb. Read More

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December 2018

Chemical methods for determining the electron storage capacity of black carbon.

MethodsX 2018 17;5:1515-1520. Epub 2018 Nov 17.

Department of Civil and Environmental Engineering, University of Delaware, Newark, DE, 19716, United States.

Electron storage capacity (ESC) is a new and important property that determines the capacity of a black carbon to mediate abiotic and microbial electron transfer reactions in natural and engineered systems. It is necessary to develop accurate and reproducible methods to measure black carbon's ESC in order to understand its redox behavior and to predict its capacity to support redox transformation of contaminants in subsurface environments. In this study, we developed chemical methods that employed combinations of reductants and oxidants of different redox potentials - Ti(III) citrate or dithionite as reductant, and ferricyanide or dissolved O as oxidant - to measure the ESC of a wood-derived biochar. Read More

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November 2018

Mining and biodiversity: key issues and research needs in conservation science.

Proc Biol Sci 2018 Dec 5;285(1892). Epub 2018 Dec 5.

Centre for Biodiversity and Conservation Science, The University of Queensland, Queensland 4072, Australia.

Mining poses serious and highly specific threats to biodiversity. However, mining can also be a means for financing alternative livelihood paths that, over the long-term, may prevent biodiversity loss. Complex and controversial issues associated with mining and biodiversity conservation are often simplified within a narrow frame oriented towards the negative impacts of mining at the site of extraction, rather than posed as a series of challenges for the conservation science community to embrace. Read More

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December 2018

TARGET SITE MODEL: PREDICTING MODE OF ACTION AND AQUATIC ORGANISM ACUTE TOXICITY USING ABRAHAM PARAMETERS AND FEATURE WEIGHTED K-NEAREST NEIGHBORS CLASSIFICATION.

Environ Toxicol Chem 2018 Dec 3. Epub 2018 Dec 3.

Department of Civil and Environmental Engineering, University of Delaware, Newark, Delaware 19716, USA.

A database of 1,480 chemicals with 47 associated modes of action compiled from literature encompasses a wide range of chemical classes (alkanes, polycyclic aromatic hydrocarbons, pesticides, and polar compounds) and includes toxicity data for 79 different aquatic genera. The data was split into a calibration and validation group (80/20) to apply k-Nearest Neighbors (k-NN) methodology to predict the toxic mode of action (MoA) for the compound. Other approaches were tested (support vector machines and linear discriminant analysis) as well as variations in the k-NN technique (distance weighting, feature weighting). Read More

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December 2018
2 Reads

Racial Disparities in the Presentation, Early Definitive Surgical Treatment, and Mortality Among Men Diagnosed with Poorly Differentiated/Undifferentiated Non-metastatic Prostate Cancer in the USA.

J Racial Ethn Health Disparities 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, University of Minnesota, 420 Delaware St SE, Minneapolis, MN, 55455, USA.

Objective: To assess the influence of race on presentation of poorly differentiated/undifferentiated prostate cancer, use of radical prostatectomy (RP) as primary treatment and survival outcomes.

Methods: Using the 2004-2014 files of the Surveillance, Epidemiology, and End Results (SEER) data, we identified 244,167 black and white men diagnosed with poorly differentiated/undifferentiated prostate cancer. Demographic and tumor characteristics of study patients were compared by race. Read More

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November 2018
2 Reads

Functional Gene Knockout of Increases Chemosensitivity of Human Lung Cancer A549 Cells and in a Xenograft Mouse Model.

Mol Ther Oncolytics 2018 Dec 18;11:75-89. Epub 2018 Oct 18.

Gene Editing Institute, Helen F. Graham Cancer Center & Research Institute, Christiana Care Health System, 4701 Ogletown-Stanton Road, Suite 4300, Newark, DE 19713, USA.

Recent studies point to the evolution of drug resistance in lung cancer as being centered, at least in part, on the upregulation of various genes involved in controlling efflux or drug inactivation. Among the most important of these genes is Nuclear Factor Erythroid 2-Related Factor (), considered the master regulator of 100-200 target genes involved in cellular responses to oxidative and/or electrophilic stress. With increased focus on the development of combinatorial approaches for cancer treatment, we utilized CRISPR/Cas9 to disable the gene in lung cancer cells by disrupting the NRF2 nuclear export signal (NES) domain; phenotypically, the protein is largely blocked from transiting into the nucleus after translation. Read More

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December 2018

Poor Performance on Single-Legged Hop Tests Associated With Development of Posttraumatic Knee Osteoarthritis After Anterior Cruciate Ligament Injury.

Orthop J Sports Med 2018 Nov 26;6(11):2325967118810775. Epub 2018 Nov 26.

Biomechanics and Movement Science Program, University of Delaware, Newark, Delaware, USA.

Background: The risk for knee osteoarthritis (OA) is substantially increased after anterior cruciate ligament (ACL) injury. Tools are needed to identify characteristics of patients after ACL injury who are most at risk for posttraumatic OA.

Purpose: To determine whether clinical measures of knee function after ACL injury are associated with the development of radiographic knee OA 5 years after injury. Read More

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November 2018
2 Reads

Transjugular Removal of a Retained Intraportal Procurement Cannula in a Liver Transplant Recipient.

J Vasc Interv Radiol 2018 Dec;29(12):1778-1780

Division of Transplantation, Department of Surgery, University of Minnesota Medical School, Mayo Mail Code 195, 420 Delaware Street SE, Minneapolis, MN 55455.

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December 2018

Cofactors of Pediatric Tinnitus: A Look at the Whole Picture.

Clin Pediatr (Phila) 2018 Dec 3:9922818816426. Epub 2018 Dec 3.

6 Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Retrospective chart review of 248 children (1-19 years old) with tinnitus who presented to a tertiary pediatric hospital between 2006 and 2011, looking at which cofactors are predictors of pediatric tinnitus. In our review, we extracted demographics, symptoms, historical data, imaging, and laboratory results; we compared with the general population. Eighty-seven percent had normal hearing. Read More

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December 2018
1 Read

Nuclear Charge Radii of ^{229}Th from Isotope and Isomer Shifts.

Phys Rev Lett 2018 Nov;121(21):213001

Physikalisch-Technische Bundesanstalt, 38116 Braunschweig, Germany.

The isotope ^{229}Th is unique in that it possesses an isomeric state of only a few electron volts above the ground state, suitable for nuclear laser excitation. An optical clock based on this transition is expected to be a very sensitive probe for variations of fundamental constants, but the nuclear properties of both states have to be determined precisely to derive the actual sensitivity. We carry out isotope shift calculations in Th^{+} and Th^{2+} including the specific mass shift, using a combination of configuration interaction and all-order linearized coupled-cluster methods and estimate the uncertainty of this approach. Read More

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November 2018

Distinct genes and pathways associated with transcriptome differences in early cardiac development between fast- and slow-growing broilers.

PLoS One 2018 5;13(12):e0207715. Epub 2018 Dec 5.

Department of Animal Science, Iowa State University, Ames, IA, United States of America.

Modern fast-growing broilers are susceptible to cardiac dysfunctions because their relatively small hearts cannot adequately meet the increased need of pumping blood through a large body mass. To improve cardiac health in broilers through breeding, we need to identify the genes and pathways that contribute to imbalanced cardiac development and occurrence of heart dysfunction. Two broiler lines-Ross 708 and Illinois-were included in this study as models of modern fast-growing and heritage slow-growing broilers, respectively. Read More

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December 2018
5 Reads

Gene expression profiling of the early pathogenesis of wooden breast disease in commercial broiler chickens using RNA-sequencing.

PLoS One 2018 5;13(12):e0207346. Epub 2018 Dec 5.

Department of Animal and Food Sciences, University of Delaware, Newark, Delaware, United States of America.

Wooden Breast Disease (WBD), a myopathy in commercial broiler chickens characterized by abnormally firm consistency of the pectoral muscle, impacts the poultry industry negatively due to severe reduction in meat quality traits. To unravel the molecular profile associated with the onset and early development of WBD in broiler chickens, we compared time-series gene expression profiles of Pectoralis (P.) major muscles between unaffected and affected birds from a high-breast-muscle-yield, purebred broiler line. Read More

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December 2018
2 Reads

Crystal structure of the layered arsenide RbCuAs.

Acta Crystallogr C Struct Chem 2018 Dec 22;74(Pt 12):1715-1718. Epub 2018 Nov 22.

Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA.

The crystal structure of a new arsenide, RbCuAs (trirubidium tricopper diarsenide), has been established from single-crystal X-ray diffraction data. This compound crystallizes in the KCuP type, with layers of interlinked CuAs units. The partitioning of the available valence electrons yields the charge-balanced composition (Rb)(Cu)(As), placing this phase in a broad field of transition-metal-containing Zintl phases. Read More

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December 2018

An Eye-Tracking Study of Receptive Verb Knowledge in Toddlers.

J Speech Lang Hear Res 2018 Dec;61(12):2917-2933

Department of Speech, Language, & Hearing Sciences, Boston University, MA.

Purpose: We examined receptive verb knowledge in 22- to 24-month-old toddlers with a dynamic video eye-tracking test. The primary goal of the study was to examine the utility of eye-gaze measures that are commonly used to study noun knowledge for studying verb knowledge.

Method: Forty typically developing toddlers participated. Read More

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December 2018
5 Reads

Utilization of High-Cost Interventions for Targeted Clinical Conditions During the Early Stages of ACO Development in a Commercially Insured Population.

Popul Health Manag 2018 Dec 4. Epub 2018 Dec 4.

2 National Pharmaceutical Council , Washington, District of Columbia.

This study compared utilization patterns of high-cost services and medications for patients receiving care from Accountable Care Organization (ACO)-participating physicians and those receiving care from non-ACO physicians during the initial phases of ACO development in a commercially insured environment. Patients ≥18 years (≥40 years for chronic obstructive pulmonary disease [COPD]) with prevalent rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, type 2 diabetes, COPD, or chronic low back pain between January 1, 2012, and August 31, 2014 were identified in the HealthCore Integrated Research Database. Patients were assigned to the ACO cohort if their primary treating physician was contracted to the health plan through an ACO agreement. Read More

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December 2018
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Differences in means-end exploration between infants at risk for autism and typically developing infants in the first 15 months of life.

Dev Psychobiol 2018 Dec 3. Epub 2018 Dec 3.

Department of Kinesiology, Physical Therapy Program, University of Connecticut, Storrs, Connecticut.

Our study compared means-end exploration in infants at risk (AR) for autism and typically developing (TD) infants using a nested box paradigm. Sixteen AR and 16 TD infants were observed at 9, 12, and 15 months with follow-up at 18 and 24 months. We collected video data on three tasks involving retrieval of a small toy by opening (a) an opaque box, (b) a transparent box, and (c) two nested boxes. Read More

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December 2018
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Enhanced sensitivity to cholera toxin in female ADP-ribosylarginine hydrolase (ARH1)-deficient mice.

PLoS One 2018 30;13(11):e0207693. Epub 2018 Nov 30.

Pulmonary Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, United States of America.

Cholera toxin, an 84-kDa multimeric protein and a major virulence factor of Vibrio cholerae, uses the ADP-ribosyltransferase activity of its A subunit to intoxicate host cells. ADP-ribosylation is a posttranslational modification of proteins, in which the ADP-ribose moiety of NAD+ is transferred to an acceptor. In mammalian cells, ADP-ribosylation of acceptors appears to be reversible. Read More

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November 2018
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The association of frontal plane alignment to MRI-defined worsening of patellofemoral osteoarthritis: the MOST study.

Osteoarthritis Cartilage 2018 Nov 28. Epub 2018 Nov 28.

Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, MA, USA; Department of Physical Therapy, University of Delaware, Newark, USA. Electronic address:

Objective: To determine the sex-specific relation of frontal plane alignment (FPA) to magnetic resonance imaging (MRI)-defined features of patellofemoral osteoarthritis, and also to tibiofemoral osteoarthritis and knee pain.

Method: The Multicenter Osteoarthritis Study is cohort study comprised of individuals with or at risk of knee osteoarthritis. We determined the sex-specific dose-response relation of baseline FPA to MRI-defined patellofemoral and tibiofemoral structural worsening, and incident knee pain, over 7 years. Read More

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November 2018
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