Search Our Scientific Publications & Authors

Neurobiol Dis 2022 Jun 25:105804. Epub 2022 Jun 25.

Department of Translational Neuroscience, Michigan State University, Grand Rapids, MI, USA. Electronic address:

Neuroinflammation has become a well-accepted pathologic hallmark of Parkinson's disease (PD). However, it remains unclear whether inflammation, triggered by α-syn aggregation and/or degeneration, contributes to the progression of the disease. Studies examining neuroinflammation in PD are unable to distinguish between Lewy body-associated inflammation and degeneration-associated inflammation, as both pathologies are present simultaneously. Read More

Gac Med Mex 2022 ;158(2):104-109

Neuroimmunoendocrinology Laboratory, Instituto Nacional de Neurología y Neurocirugía "Manuel Velasco Suárez".

Introduction: Fibromyalgia (FM) is a non-degenerative syndrome characterized by generalized, chronic musculoskeletal pain, as well as mood, memory and sleep disorders.

Objective: To search for serum anti-neural antibodies (ANeuA) in patients with FM (FMP) in order to rule out autoimmune etiology.

Methods: The Fibromyalgia Impact Questionnaire (FIQ) and Beck's depression inventory (BDI) were applied. Read More

Curr Eye Res 2022 Jun 28:1-34. Epub 2022 Jun 28.

Department of Ophthalmology, the Fourth Affiliated Hospital of China Medical University, 155 North Nanjing Street, Heping District, Shenyang, Liaoning Province 110001 PR China.

Purpose: Clinical trials using fetal retinal pigment epithelium (fRPE), human embryonic stem cell (hESC)-derived RPE, or human induced pluripotent stem cell (hiPSC)-derived RPE for cell-based therapy for degenerative retinal diseases have been carried out. We investigated the culture-induced changes in passaged fRPE, hESC-RPE and hiPSC-RPE cells and explored the differentiation and maturation effect of all-trans retinoic acid (ATRA) on cells for manufacturing and screening high quality RPE cells for clinical transplantation.

Methods: RPE cell lines were set up and the culture-induced changes in subsequent passages caused by manipulating plating density, dissociation method and repeated passaging were studied by microscope, real-time quantitative PCR, western blot and immunofluorescent assays. Read More

Am J Sports Med 2022 Jun 28:3635465221104708. Epub 2022 Jun 28.

Sports Medicine and Arthroscopy Center, Yagi Orthopaedic Hospital, Sapporo, Japan.

Background: Recent studies have reported that medial opening wedge (OW) high tibial osteotomy (HTO) induces patella baja, resulting in degenerative changes in the patellofemoral joint. We have developed an inverted V-shaped (iV) HTO, which is classified as a neutral wedge osteotomy.

Hypotheses: The study hypotheses were as follows: (1) patellar height, posterior tibial slope, and tibial length will not change between pre- and postoperative evaluations after iV-HTO; (2) the lateral shift ratio of the patella and the distance between the tibial tubercle and the trochlear groove may be significantly decreased after iV-HTO. Read More

Curr Stem Cell Res Ther 2022 Jun 28. Epub 2022 Jun 28.

Applied Biotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Intervertebral disc degeneration [IDD] is recognized as an aging process, important and most common pathological condition caused by an imbalance of anabolic and catabolic metabolisms in the intervertebral disc [IVD] and leads to changes in the extracellular matrix [ECM], impaired metabolic regulation of nucleus pulposus [NP], and increased oxidative stress. IDD is mostly associated with pain in the back and neck, which is referred to as a type of disability. Pharmacological and surgical interventions are currently used to treat IDD, but evidence has shown that these interventions do not have the ability to inhibit the progression of IDD and restore IVD function because IVD lack the intrinsic capacity for regeneration. Read More

Anat Histol Embryol 2022 Jun 28. Epub 2022 Jun 28.

Emergency Clinical County Hospital Cluj-Napoca, Cluj-Napoca, Romania.

The pineal gland is a small-sized, photo neuroendocrine organ in the midline of the brain that synthesises and secretes melatonin and serotonin. Chords and islands of pinealocytes constitute the secretory parenchyma, while glial tissue and calcifications represent degenerative changes. This study examined human postmortem pineal glands to microscopically assess morphological changes possibly associated with clinical data, by using digital techniques. Read More

Vascular 2022 Jun 28:17085381221111010. Epub 2022 Jun 28.

Department of Radiology, St. Vincent's Hospital, College of Medicine, 65645The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: To explore the etiology of May-Thurner syndrome (MTS) with acute iliofemoral deep vein thrombosis (DVT) regarding imaging findings and clinical features.

Methods: We retrospectively analyzed 57 patients with acute left iliofemoral DVT from 2015 to 2020. The diameter of left common iliac vein (LCIV) at the maximal compression site and its percent compression regarding the average diameter of the uncompressed iliac vein were recorded in central and distal portions of the LCIV according to the location in the quadrant of lumbar vertebral body. Read More

Chem Biodivers 2022 Jun 27. Epub 2022 Jun 27.

Marmara University: Marmara Universitesi, Pharmaceutical Chemistry, Başıbüyük, 34854, Istanbul, TURKEY.

The development of new enzyme inhibitors in degenerative brain diseases has gained more attention. Enzyme inhibitors play an effective role in controlling central nervous system diseases. For this purpose, a novel series of hydrazone derivatives containing imidazolidine ring aimed against Alzheimer's disease (AD), have been designed and synthesized. Read More

Oxid Med Cell Longev 2022 18;2022:7911222. Epub 2022 Jun 18.

Department of Physiology, Anatomy and Neuroscience, Faculty of Science and Informatics, University of Szeged, 6726 Szeged, Hungary.

According to a widely accepted theory, oxidative stress is considered to be the number one trigger of aging-associated degenerative processes including cardiovascular diseases. In the context of aging-research, resveratrol receives special attention with its surprising number of health benefits. The aim of our study was to examine the anti-inflammatory and antioxidant effects of this dietary polyphenol in aging rat heart. Read More

BMC Musculoskelet Disord 2022 Jun 27;23(1):611. Epub 2022 Jun 27.

Department of Spinal Surgery, Orthopedic Center, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510280, China.

Background: Oblique lateral interbody fusion (OLIF) is widely used to treat lumbar degenerative disc disease. This study aimed to evaluate the biomechanical stability of OLIF, OLIF including posterior pedicle screw and rod (PSR), and OLIF including cortical screw and rod (CSR) instrumentation through finite element analysis.

Methods: A complete L2-L5 finite element model of the lumbar spine was constructed. Read More

Neurol Sci 2022 Jun 28. Epub 2022 Jun 28.

Sorbonne Université, AP-HP, Institut du Cerveau - Paris Brain Institute - ICM, Inserm, CNRS, Hôpitaux Universitaires La Pitié Salpêtrière - Charles Foix, DMU Neurosciences, Service de Neurologie 2-Mazarin, F-75013, Paris, France.

Langerhans cell histiocytosis (LCH) is a rare inflammatory myeloid neoplasm characterized by proliferation of tumor histiocytes that involves multiple organs including central nervous system. The physiopathologic process underlying degenerative neuro-LCH (i.e. Read More

Best Pract Res Clin Rheumatol 2022 Jun 24:101761. Epub 2022 Jun 24.

Centre for Molecular Medicine and Innovative Therapeutics, Murdoch University, Perth, WA, Australia; Perron Institute for Neurological and Translational Science, Perth, WA, Australia; School of Medicine, University of Notre Dame, Fremantle, WA, Australia; Fiona Stanley Hospital, Department of Neurology, Perth, WA, Australia.

Inclusion body myositis (IBM) is a slowly progressive muscle disease affecting ageing individuals. IBM presents with a distinctive pattern of weakness involving the quadriceps and finger flexor muscles, although other muscles including pharyngeal muscles become affected over time. Pathological hallmarks of IBM include autoimmune features, including endomysial infiltration by highly differentiated T cells, as well as degenerative features marked by intramyofibre protein aggregates organised into inclusion bodies. Read More

J Craniomaxillofac Surg 2022 Jun 17. Epub 2022 Jun 17.

Department of Preventive Medicine, Public Health and History of Science. Complutense University of Madrid, Pza. Ramón y Cajal, s/n, 28040, Madrid, Spain.

The purpose of the study was to assess the long-term oral health-related quality of life (oQoL) in patients with temporomandibular joint (TMJ) internal derangement (ID) after TMJ arthrocentesis plus hyaluronic acid (HA). Patients were analysed at different follow-up times using an analytical observational design. The Oral Health Impact Profile-14 (OHIP-14) score was evaluated according to age, sex, disc position, presence of degenerative joint disease (DJD), joint pain, maximum mouth opening and follow-up time. Read More

Clin Spine Surg 2022 Jun 23. Epub 2022 Jun 23.

Department of Orthopedic Surgery Maimonides Medical Center.

Study Design: A retrospective cohort study was performed for patients undergoing 1-2-level lumbar fusion (1-2LF) from 2005 to 2014 using an administrative claims database.

Objective: The objective of this study was to determine changes in: (1) annual charges; (2) annual reimbursement rates; and (3) annual difference (charges minus reimbursements) in patients undergoing 1-2LF.

Summary Of Background Data: With implementation of value-based care in orthopaedics, coupled with the rise in number of patients undergoing 1-2LF, understanding the discordance in hospital charges and reimbursements is needed. Read More

Clin Spine Surg 2022 Jul 24;35(6):294. Epub 2022 Jun 24.

Neurol Sci 2022 Jun 27. Epub 2022 Jun 27.

Neurophysiology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, 20133, Milan, Italy.

Objectives: To investigate the relationship between N20-P25 peak-to-peak amplitude (N20p-P25p) of somatosensory evoked potentials (SEPs) and the occurrence of abnormalities of the peripheral and/or central sensory pathways and of myoclonus/epilepsy, in 308 patients with increased SEPs amplitude from upper limb stimulation.

Methods: We compared cortical response (N20p-P25p) in different groups of patients identified by demographic, clinical, and neurophysiological factors and performed a cluster analysis for classifying the natural occurrence of subgroups of patients.

Results: No significant differences of N20p-P25p were found among different age-dependent groups, and in patients with or without PNS/CNS abnormalities of sensory pathways, while myoclonic/epileptic patients showed higher N20p-P25p than other groups. Read More

Zh Nevrol Psikhiatr Im S S Korsakova 2022 ;122(6):77-84

Research Center of Neurology, Moscow, Russia.

Objective: To identify clinical and laboratory indicators associated with the development of chronic musculoskeletal pain syndrome in young and middle-aged patients with degenerative changes of the spine.

Material And Methods: The study included 103 patients (59 women and 44 men) with a mean age 42 [36; 47] years with chronic musculoskeletal back pain. To verify degenerative changes of the spine, MRI was performed using Magnetom Symphony (Siemens; Germany), Magnetom Verio (Siemens; Germany) devices. Read More

J Zoo Wildl Med 2022 Jun;53(2):349-356

Disease Investigations, San Diego Wildlife Alliance, San Diego, CA 92112, USA.

Kirk's dik-diks () are the most common dik-dik species managed in North American zoological institutions, but their numbers are declining at a concerning rate, with less than 40 individuals currently housed in accredited institutions. This retrospective study reports the causes of mortality in Kirk's dik-diks in North American zoological institutions from 1988 to 2019. Out of 15 institutions accredited by the Association of Zoos and Aquariums (AZA) currently housing Kirk's dik-diks, nine contributed to this study (60% participation). Read More

Cell Transplant 2022 Jan-Dec;31:9636897221104451

Institute for Vision Research, University of Iowa, Iowa City, IA, USA.

Loss of photoreceptor cells is a primary feature of inherited retinal degenerative disorders including age-related macular degeneration and retinitis pigmentosa. To restore vision in affected patients, photoreceptor cell replacement will be required. The ideal donor cells for this application are induced pluripotent stem cells (iPSCs) because they can be derived from and transplanted into the same patient obviating the need for long-term immunosuppression. Read More

Dis Model Mech 2022 Jun 27. Epub 2022 Jun 27.

Department of Ophthalmology & Vision Science, School of Medicine, U.C. Davis, USA.

Retinitis Pigmentosa (RP), a retinal degenerative disease, is the leading cause of heritable blindness. Previously, we described that Arap1-/- mice develop a similar pattern of photoreceptor degeneration. Arap1 is an Arf-directed GTPase-activating protein (GAP) shown to modulate actin cytoskeletal dynamics. Read More

Fed Pract 2022 Apr 12;39(4):186-189. Epub 2022 Apr 12.

Orlando Veterans Affairs Healthcare System, Florida.

Background: For decades, the total hip arthroplasty procedure of choice has been a standard posterior approach. In the past several years, modified muscle-sparing surgical approaches have been introduced, including the mini posterior and direct anterior approaches. However, the optimal surgical approach is still being debated. Read More

Front Cell Dev Biol 2021 9;9:778941. Epub 2022 Jun 9.

Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.

Osteoarthritis (OA) is a degenerative joint disease characterized by articular cartilage degradation. Dysregulated autophagy is a major cause of OA. However, the underlying mechanism is unclear. Read More

Front Med (Lausanne) 2022 8;9:944769. Epub 2022 Jun 8.

Université de Strasbourg, Inserm, IRFAC/UMR-S1113, FMTS, Strasbourg, France.

Front Pharmacol 2022 8;13:904849. Epub 2022 Jun 8.

Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Lam. (CCL) is a medicinal herb widely used in traditional Chinese medicine for the treatment of ophthalmic diseases, including age-dependent vision-threatening retinal degenerative disorders that involve irreversible loss of the first-order retinal neurons, photoreceptors. However, evidence is lacking if CCL is pharmacologically active at protecting against loss of photoreceptors and photoreceptor degeneration-associated retinal structural and functional impairment. Read More

Front Pharmacol 2022 8;13:860598. Epub 2022 Jun 8.

Afzalipour School of Medicine and Pathology and Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Leishmaniasis has been identified as a significant disease in tropical and subtropical regions of the world, with Iran being one of the disease-endemic areas. Various treatments have been applied for this disease, and amphotericin B (Amp B) is the second line of treatment. Side effects of this drug have been reported in various organs. Read More

Front Pharmacol 2022 8;13:914338. Epub 2022 Jun 8.

European Organisation for Rare Diseases (EURORDIS), Paris, France.

Rare diseases (RDs) are a severe, chronic, degenerative and often life-threatening group of conditions affecting more than 30 million people in Europe. Their impact is often underreported and ranges from psychological and physical symptoms seriously compromising quality of life. There is then a need to consolidate knowledge on the economic, social, and quality of life impacts of rare diseases. Read More

Crit Rev Anal Chem 2022 Jun 26:1-16. Epub 2022 Jun 26.

Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq.

In today's world, Parkinson's disease (PD) has been introduced as a long-term degenerative disorder of the central nervous system which mainly affects approximately more than ten million people worldwide. The vast majority of diagnostic methods for PD have operated based on conventional sensing platforms, while the traditional laboratory tests are not efficient for diagnosis of PD in the early stage due to symptoms of this common neurodegenerative syndrome starting slowly. The advent of the aptasensor has revolutionized the early-stage diagnosis of PD by measuring related biomarkers due to the myriad advantages of originating from aptamers which can be able to sensitive and selective capture various types of related biomarkers. Read More

J Neuromuscul Dis 2022 Jun 20. Epub 2022 Jun 20.

Friedrich-Baur-Institute, Department of Neurology, Ludwig-Maximilians-University of Munich, Munich, Germany.

Background: Anti-3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)-myopathy is a usually rapidly progressive form of immune-mediated necrotizing myopathy (IMNM). Rarer clinical courses show slow progression and resemble the phenotype of limb-girdle dystrophy (LGMD).

Objective: We demonstrate the difficulties in differentiating LGMD versus anti-HMGCR-myopathy. Read More

J Hand Surg Am 2022 Jun 23. Epub 2022 Jun 23.

Anatomy Department, School of Medicine, University of Buenos Aires, Argentina.

Purpose: We evaluated the clinical outcomes of a series of patients with hyperextension deformity of the proximal interphalangeal joint treated with volar capsulodesis.

Methods: This retrospective study included 16 patients with symptomatic locking of the proximal interphalangeal joint who underwent volar capsulodesis and were followed for at least 2 years. We excluded patients with severe, degenerative changes on plain radiographs. Read More

Spine J 2022 Jun 23. Epub 2022 Jun 23.

Department of Clinical Sciences Lund, Neurosurgery, Lund University, Skåne University Hospital, Lund, Sweden.

Background Context: Degenerative cervical spondylotic myelopathy (DCM) is the commonest form of spinal cord injury in adults. However, a limited number of clinical reports have evaluated the role of biomarkers in DCM.

Purpose: We evaluated cerebrospinal fluid (CSF) biomarkers in patients scheduled for DCM surgery and hypothesized that CSF biomarkers levels 1) would reflect the severity of preoperative neurological status; and 2) correlate with radiological appearance as well as clinical outcome. Read More