59,370 results match your criteria Degenerative Lumbar Disc Disease in the Mature Athlete


Validation of the Acetabulum As a Skeletal Indicator of Age at Death in Modern European-Americans.

J Forensic Sci 2018 Dec 10. Epub 2018 Dec 10.

Department of Anthropology, University of West Florida, 11000 University Parkway, Bldg. 13, Pensacola, FL, 32514.

Progressive changes in the acetabulum have been used in modern skeletal age estimation, but they have not been completely understood. If their age correlations are weakened by the influence of factors like physical activity and obesity, acetabular changes should not be used for age estimation. To investigate their utility for aging, the acetabular variables of Rissech et al. Read More

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December 2018

Perturbed expression pattern of the immediate early gene Arc in the dentate gyrus of GluA1 C-terminal palmitoylation-deficient mice.

Neuropsychopharmacol Rep 2018 Dec 7. Epub 2018 Dec 7.

Section of Cellular Biochemistry, Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan.

Background: AMPA receptors predominantly mediate fast excitatory synaptic transmission in the mammalian brain. Post-translational protein S-palmitoylation of AMPA receptor GluA subunits at their C-termini reversibly controls the receptors trafficking to and from excitatory glutamatergic synapses. Excitatory inputs to neurons induce the expression of immediate early genes (IEGs), including Arc, with particular spatial patterns. Read More

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December 2018
1 Read

Expression of lamin A/C protein in degenerated human intervertebral disc.

Eur Rev Med Pharmacol Sci 2018 Nov;22(22):7607-7613

Department of Spine Surgery, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Objective: This study aimed to evaluate the expression characteristics of lamin A/C proteins in intervertebral disc degeneration (IVD) specimens from patients with different degeneration grades. Lamin A/C proteins have been shown to result in age-related changes in the osteoarticular system. However, the expression characteristics of these nuclear proteins in degenerated human IVD tissues have not been explored previously. Read More

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November 2018

[Speech and Language Disorders in the Elderly].

Authors:
Arno Olthoff

Laryngorhinootologie 2018 Dec 10;97(12):846-851. Epub 2018 Dec 10.

Phoniatrie und Pädaudiologie Göttingen, Klinik für Hals-, Nasen- und Ohrenheilkunde.

Cerebrovascular insults and neurodegenerative diseases are the main causes of acquired speech and language disorders. A massive increase in the prevalence of both is evident from the age of 65 years. By the age of 90 years, more than 10 % of the population would have experienced a stroke and 30 % would have suffered from neurodegenerative diseases. Read More

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December 2018

PEEK versus metal cages in posterior lumbar interbody fusion: a clinical and radiological comparative study.

Musculoskelet Surg 2018 Dec 10. Epub 2018 Dec 10.

S.C. Ortopedia e Traumatologia, IRCCS Policlinico San Matteo, Università degli Studi di Pavia, Viale Camillo Golgi 19, 27100, Pavia, PV, Italy.

Background: Low back pain and sciatica represent a common disabling condition with a significant impact on the social, working and economic lives of patients. Transforaminal lumbar interbody fusion (TLIF) is a surgical procedure used in degenerative spine conditions. Several types of cages were used in the TLIF procedure. Read More

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December 2018

[The trend towards full-endoscopic decompression : Current possibilities and limitations in disc herniation and spinal stenosis].

Authors:
S Ruetten M Komp

Orthopade 2018 Dec 7. Epub 2018 Dec 7.

Zentrum für Wirbelsäulenchirurgie und Schmerztherapie, Zentrum für Orthopädie und Unfallchirurgie der St. Elisabeth Gruppe - Katholische Kliniken Rhein-Ruhr, St. Anna Hospital Herne/Universitätsklinikum, Marien Hospital Herne/Marien Hospital Witten, Hospitalstr. 19, 44649, Herne, Deutschland.

Background: The most frequent causes of degenerative constrictions of the spinal canal are disk herniations and spinal stenoses. The lumbar and cervical spine is the most affected.

Surgical Procedures: After conservative treatments have been exhausted, surgical intervention may be necessary. Read More

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December 2018

Lumbar Schmorl's Nodes and Their Correlation with Spine Configuration and Degeneration.

Biomed Res Int 2018 7;2018:1574020. Epub 2018 Nov 7.

Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 6997801, Israel.

The aim of this study was to reveal whether demographic aspect, vertebral morphometry, and spine degeneration are associated with lumbar Schmorl's nodes (SNs). A retrospective cross-sectional study was performed using data from the Department of Radiology (Carmel, Medical Center, Israel) for 180 individuals: age range between 40 and 99 years; 90 males and 90 females. All participants had undergone high-resolution CT scans for abdominal diagnostic purposes in the same supine position prior to our study, which enabled the processing of the scans in all planes and allowed a 3D reconstruction of the lower lumbar region. Read More

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November 2018
1 Read

Lipoproteins in Cardiovascular Calcification: Potential Targets and Challenges.

Front Cardiovasc Med 2018 23;5:172. Epub 2018 Nov 23.

Department of Medicine, University of California, Los Angeles, Los Angeles, CA, United States.

Previously considered a degenerative process, cardiovascular calcification is now established as an active process that is regulated in several ways by lipids, phospholipids, and lipoproteins. These compounds serve many of the same functions in vascular and valvular calcification as they do in skeletal bone calcification. Hyperlipidemia leads to accumulation of lipoproteins in the subendothelial space of cardiovascular tissues, which leads to formation of mildly oxidized phospholipids, which are known bioactive factors in vascular cell calcification. Read More

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November 2018

Knee Arthroscopy: A Diagnostic and Therapeutic Tool for Management of Ochronotic Arthropathy.

Arthrosc Tech 2018 Nov 1;7(11):e1097-e1101. Epub 2018 Oct 1.

Stetson Powell Orthopedics and Sports Medicine, Burbank, California, U.S.A.

The surgical treatment of ochronotic arthropathy remains unclear. Although there is no absolute cure for ochronotic arthropathy, current management typically begins with conservative treatment. Total joint replacement may eventually be necessary for joints that become severely degenerative. Read More

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November 2018

Involvement of inflammatory responses in the early development of calcific aortic valve disease: lessons from statin therapy.

Anim Cells Syst (Seoul) 2018 28;22(6):390-399. Epub 2018 Sep 28.

Department of Life Science, College of Natural Sciences, Research Institute for Natural Sciences, Hanyang University, Seoul, Republic of Korea.

Calcific aortic valve disease (CAVD) is the most common degenerative heart valve disease. Among the many risk factors for this disease are age, hypercholesterolemia, hypertension, smoking, type-2 diabetes, rheumatic fever, and chronic kidney disease. Since many of these overlap with risk factors for atherosclerosis, the molecular and cellular mechanisms of CAVD development have been presumed to be similar to those for atherogenesis. Read More

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September 2018

Optical coherence tomography findings in patients prior to cataract surgery regarded as unremarkable with ophthalmoscopy.

PLoS One 2018 11;13(12):e0208980. Epub 2018 Dec 11.

Department of Ophthalmology, University Medical Center Goettingen, Germany.

Purpose: To investigate the feasibility and diagnostic benefit of routinely performed preoperative macular spectral-domain (SD-) optical coherence tomography (OCT) for the detection of macular pathology in patients with normal biomicroscopic funduscopy prior to cataract surgery.

Methods: Prospective, single center study. A total of 162 eyes of 123 consecutive patients referred for cataract surgery with a visual acuity better than 20/100, absence of macular symptoms such as metamorphopsia, no history of previous intravitreal procedures and a normal funduscopic appearance on biomicroscopy underwent an additional SD-OCT-examination prior to cataract surgery. Read More

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December 2018

Cervical disc degeneration and neck pain.

J Pain Res 2018 14;11:2853-2857. Epub 2018 Nov 14.

Interventional Spine and Musculoskeletal Care, Virginia iSpine Physicians, PC Virginia Spine Research Institute, Inc Richmond, VA, USA.

Cervical intervertebral disc has long been considered a common source of neck pain. However, the pain caused by the disc itself has not been clearly defined so far, and its diagnosis and treatment has always been controversial. Degenerative cervical disc has a rich supply of nerve fibers, is prone to inflammatory reactions, and is susceptible to pain that can be provoked by disc stimulation or distention, and can be eliminated by block. Read More

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November 2018

In Vivo Evaluation of PAX6 Overexpression and NMDA Cytotoxicity to Stimulate Proliferation in the Mouse Retina.

Sci Rep 2018 Dec 7;8(1):17700. Epub 2018 Dec 7.

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Retinal degenerative diseases, due to the lack of regeneration systems and self-renewable cells, often lead to visual impairment. Pax6 is a pleiotropic transcription factor and its expression level determines self-renewal status or differentiation of retinal cells. Here, we investigated the fate of simultaneous induction of retinal ganglion cell death and Pax6 overexpression in retro-differentiation of retinal cells and their commitment to re-enter into the cell cycle. Read More

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December 2018

The assessment of retina in pregnant women with myopia.

Authors:

Neuro Endocrinol Lett 2018 Oct 10;39(4). Epub 2018 Oct 10.

Objectives: Myopia is associated with increased frequency of retinal degenerative changes which are the risk factors of intra- and postpartal ophthalmological complications. Aim of this study was to analyze the degenerative lesions detected in opthalmological examination (including peripheral retinal lesions) as a potential risk factors for eyes' status in terms of delivery in myopic women.

Material And Methods: 254 pregnant women affected with myopia underwent opthalmological examination as a screening method to examine retina. Read More

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October 2018

Rupture of the Patellar Tendon After Platelet-Rich Plasma Treatment: A Case Report.

Clin J Sport Med 2018 Dec 3. Epub 2018 Dec 3.

Sant'Andrea Hospital, Traumatology Sports Center "Kilk Kilgour," "La Sapienza" University, Rome, Italy.

Introduction: Rupture of the patellar tendon is becoming more and more frequent, even in sports activities overloading the extensor mechanism of the knee. Platelet-rich plasma (PRP) treatment has been recently introduced in treatment for several knee- and sport-related injuries including muscle strain cartilage defect and tendinopathies. The aim of this case report is to present a case of rupture of the patellar tendon occurred after injections of PRP. Read More

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December 2018

Chronic Monteggia.

Curr Opin Pediatr 2018 Dec 6. Epub 2018 Dec 6.

Pontifícia Universidade Católica do Paraná, Brasil.

Purpose Of Review: The chronic Monteggia may lead to pain, mobility limitation, progressive valgus deformity, lateral elbow instability, late ulnar nerve paralysis, and degenerative changes. In this review, we discuss the current procedures in the literature focused on correcting chronic Monteggia to avoid these complications.

Recent Findings: Correction of the ulnar deformity with elongation and angulation of the ulna in the opposite direction of the dislocation of the radial head is the most important factor for the reduction and consequent preservation of the radial head. Read More

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December 2018

Amyotrophic lateral sclerosis as a synaptopathy.

Neural Regen Res 2019 Feb;14(2):189-192

Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, USA; School of Biomedical Sciences, The University of Queensland, St. Lucia, Australia.

The synapse is an incredibly specialized structure that allows for the coordinated communication of information from one neuron to another. When assembled into circuits, steady streams of excitatory and inhibitory synaptic activity shape neural outputs. At the organismal level, ensembles of neural networks underlie behavior, emotion and memory. Read More

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February 2019

MTSS1/Src family kinase dysregulation underlies multiple inherited ataxias.

Proc Natl Acad Sci U S A 2018 Dec 7. Epub 2018 Dec 7.

Program in Epithelial Biology, Stanford University School of Medicine, Stanford, CA 94305;

The genetically heterogeneous spinocerebellar ataxias (SCAs) are caused by Purkinje neuron dysfunction and degeneration, but their underlying pathological mechanisms remain elusive. The Src family of nonreceptor tyrosine kinases (SFK) are essential for nervous system homeostasis and are increasingly implicated in degenerative disease. Here we reveal that the SFK suppressor Missing-in-metastasis (MTSS1) is an ataxia locus that links multiple SCAs. Read More

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December 2018

Biomechanically stimulated chondrocytes promote osteoclastic bone resorption in the mandibular condyle.

Arch Oral Biol 2018 Dec 3;98:248-257. Epub 2018 Dec 3.

Department of Dentistry, The 986rd Hospital of PLA Air Force, Xi'an, 710054, China.

Objective: Chondrocyte signaling is important in osteoclastic bone resorption in mice tibiae. The present study aimed to test whether biomechanically stimulated chondrocytes promote osteoclastic bone resorption in the mandibular condyle.

Methods: Primary chondrocytes isolated from rat condylar cartilage were stimulated by fluid flow shear stress (FSS) for 30, 60, 120 min at intensities of 10, 20, or 30 dynes/cm. Read More

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December 2018

Restoration of Lumbar Lordosis After Minimally Invasive Transforaminal Lumbar Interbody Fusion: A Systematic Review.

Spine J 2018 Dec 6. Epub 2018 Dec 6.

Hospital for Special Surgery, Spine Care Institute, New York, NY. Electronic address:

Background: Transforaminal lumbar interbody fusion (TLIF) is a well-accepted surgical technique for the treatment of degenerative spinal conditions and spinal deformity. The TLIF procedure can be performed open or using minimally invasive techniques. While several studies have found that minimally invasive TLIF (MI-TLIF) has advantages over open TLIF procedures with less blood loss, post-operative pain and hospital length of stay, opponents of the minimally invasive technique cite the lack of restoration of lumbar lordosis as a major drawback. Read More

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December 2018
1 Read

Role of MicroRNA-141 in the Aging Musculoskeletal System: A Current Overview.

Mech Ageing Dev 2018 Dec 6. Epub 2018 Dec 6.

Department of Orthopedics, Augusta University, Augusta, GA, United States; Institute of Regenerative and Reparative medicine, Augusta University, Augusta, GA, United States. Electronic address:

MicroRNA's are small non-coding RNAs that regulate the expression of genes by targeting the 3' UTR's of mRNA. Studies reveal that miRNAs play a pivotal role in normal musculoskeletal function such as mesenchymal stem cell differentiation, survivability and apoptosis, osteogenesis, and chondrogenesis. Changes in normal miRNA expression have been linked to a number of pathological disease processes. Read More

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December 2018

Difference of dynamic morphometric changes between in patients with ossification of posterior longitudinal ligament and patients with cervical spondylosis: Assessed by Cervical dynamic MRI.

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Department of Neurosurgery, St. Vincent`s Hospital, The Catholic University of Korea, Suwon, South Korea. Electronic address:

Purpose: The purpose of this study was to evaluate differences between thicknesses of the ligamentum flavum (LF) and diameter of the spinal canal in different neck positions in patients with ossification of the posterior longitudinal ligament (OPLL) and patients with cervical degenerative spondylosis (CDS) using cervical dynamic magnetic resonance (MR) images.

Methods: Eighty-eight patients (66 CDS and 22 OPLL) that underwent neutral and dynamic MRI at our institute from February 2014 to July 2017 were the subjects of this retrospective study. Canal diameters and LF thicknesses were measured and Muhle's grades were determined in neutral and dynamic MR images from C2-3 to C7-T1. Read More

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December 2018

Health care services and disease modifying therapies use in community-based multiple sclerosis patients: Evolution from 2013 to 2015 and demographic characteristics.

Presse Med 2018 Dec 7. Epub 2018 Dec 7.

Agence Régionale de Santé ARS, 13002 Marseille, France.

Interest Of The Work: Multiple sclerosis (MS) disease modifying therapies (DMT) utilization increased during the last decade with the approval of new drugs. Symptomatic treatments also play an important role. Describing time trends and demographic characteristics for DMT and symptomatic treatments utilization in population-based MS patients will lead to a better knowledge of the resources distribution. Read More

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December 2018

Total Hip Arthroplasty Reduces Pain and Improves Function in Patients With Spondyloepiphyseal Dysplasia: A Long-Term Outcome Study of 50 Cases.

J Arthroplasty 2018 Oct 30. Epub 2018 Oct 30.

Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN.

Background: Spondyloepiphyseal dysplasia (SED) is rare genetic condition which leads to skeletal and joint deformities that can predispose patients to degenerative joint disease. There are limited reports on the results of total hip arthroplasty (THA) in this patient population. The purpose of this study is to review clinical and radiographic outcomes of THA performed in patients with SED at one institution. Read More

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October 2018

The Unstable Spine: A Surgeon's Perspective.

Semin Ultrasound CT MR 2018 Dec 13;39(6):618-629. Epub 2018 Oct 13.

Department of Orthopedic Surgery & Rehabilitation, University of Nebraska Medical Center, Omaha, NE.

Instability of the spine is a complex clinical entity that exists on a wide spectrum encompassing many aspects of spinal pathology including traumatic, neoplastic, infectious, and degenerative processes. The importance of determining stability is paramount in the decision-making process regarding the need for operative or nonoperative care. Defining clinical instability can be a challenging and requires careful attention to the pathology involved, findings of necessary imaging, and a thorough clinical exam. Read More

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December 2018

Infectious Spondylitis Mimics: Mechanisms of Disease and Imaging Findings.

Authors:
Humberto Morales

Semin Ultrasound CT MR 2018 Dec 15;39(6):587-604. Epub 2018 Nov 15.

Section of Neuroradiology, University of Cincinnati Medical Center, Cincinnati, OH. Electronic address:

Infectious processes of the spine are on the rise; in this scenario recognition of entities imitating infection is very important. The discovertebral unit is regarded as one of the most important and active sites in the spine. Importantly, the vertebral bony rim and the anterior corners of the vertebral bodies have significant vascularization, they are the last regions to ossify in the developmental process and suffer mechanical forces. Read More

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December 2018

Transplantation of retinal progenitor cells from optic cup-like structures differentiated from human embryonic stem cells in vitro and in vivo generation of retinal ganglion-like cells.

Stem Cells Dev 2018 Dec 10. Epub 2018 Dec 10.

Fudan University, Department of Anatomy, Histology and Embryology, Shanghai, China ;

Human embryonic stem cells (hESCs) have the potential to differentiate along the retinal lineage. We have efficiently differentiated human pluripotent stem cells (hPSCs) into optic cup-like structures by using a novel retinal differentiation medium (RDM).The purpose of this study was to determine whether the retinal progenitor cells (RPCs) derived from hESCs can integrate into the host retina and differentiate into retinal ganglion cells (RGCs) in vivo. Read More

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December 2018

Radicular Pain Syndromes: Cervical, Lumbar, and Spinal Stenosis.

Semin Neurol 2018 Dec 6;38(6):634-639. Epub 2018 Dec 6.

Department of Neurology, Boston University School of Medicine, Boston University Medical Center, Boston, Massachusetts.

Back pain is a top primary and urgent care complaint; radicular pain can be caused by herniation of the nucleus pulposus (intervertebral disc), spinal stenosis, or degenerative changes to the vertebrae. The focus of this clinical review will be the clinical approach and treatment of lumbar radicular pain, cervical radicular pain, and spinal stenosis. Usually localized through neurological history, exam, and imaging, specific signs and symptoms for lumbar radicular, spinal stenosis, and cervical radicular pain can help determine etiology. Read More

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December 2018
3 Reads

An Interactive and Low-Cost Full Body Rehabilitation Framework Based on 3D Immersive Serious Games.

J Biomed Inform 2018 Dec 3. Epub 2018 Dec 3.

Department of Computer Science Sapienza University of Rome, Via Salaria 113, 00198, Rome, Italy. Electronic address:

Strokes, surgeries, or degenerative diseases can impair motor abilities and balance. Long-term rehabilitation is often the only way to recover, as completely as possible, these lost skills. To be effective, this type of rehabilitation should follow three main rules. Read More

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December 2018
1 Read

[Continuous vs. intermitent intravenous analgesia for primary total knee replacement: analysis of the quality of the pain control, hospital stay and costs].

Acta Ortop Mex 2018 May-Jun;32(3):134-139

Instituto Allende de Cirugía Reconstructiva de los Miembros, Córdoba-Argentina.

Background: The International Association for the Study of Pain (IASP) defines pain as an unpleasant sensory and emotional experience associated with actual or potential tissue damage. Total knee arthroplasty is one of the orthopedic surgeries that manifests more pain in the first 24-48 hours, needing a multimodal analgesic therapy. The objective of this work is to compare two different intravenous analgesic modes applied to patients undergoing a primary total knee arthroplasty, analyzing the quality of pain control, hospital stay and costs. Read More

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December 2018
3 Reads

[Prevalence of osteoporosis and osteopenia in patients occupationally active].

Acta Ortop Mex 2018 May-Jun;32(3):131-133

Clínica de Detección y Diagnóstico Automatizado, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado (ISSSTE), Ciudad de México.

Background: Osteoporosis is a public health problem worldwide, affecting more than 200 million people. It is estimated that 30 to 50% of postmenopausal women suffer from it. According to the International Osteoporosis Foundation (IOF), osteoporosis is a disease characterized by a decrease in the density and quality of bones. Read More

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December 2018
1 Read

Hereditary Spastic Paraplegia: gain-of-function mechanisms revealed by new transgenic mouse.

Hum Mol Genet 2018 Dec 6. Epub 2018 Dec 6.

Department of Neurobiology and Anatomy.

Mutations of the SPAST gene, which encodes the microtubule-severing protein spastin, are the most common cause of Hereditary Spastic Paraplegia. Haploinsufficiency is the prevalent opinion as to the mechanism of the disease, but gain-of-function toxicity of the mutant proteins is another possibility. Here, we report a new transgenic mouse (termed SPASTC448Y mouse) that is not haploinsufficient but expresses human spastin bearing the HSP pathogenic C448Y mutation. Read More

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December 2018

Cutibacterium acnes in Spine Pathology: Pathophysiology, Diagnosis, and Management.

J Am Acad Orthop Surg 2018 Dec 4. Epub 2018 Dec 4.

From the Department of Orthopaedics, Beaumont Health System, Royal Oak, MI.

Cutibacterium acnes, long thought to be skin flora of pathological insignificance, has seen a surge in interest for its role in spine pathology. C acnes has been identified as a pathogen in native spine infection and osteomyelitis, which has implications in the management compared with more commonly recognized pathogens. In addition, It has also been recognized as a pathogen in postoperative and implant-associated infections. Read More

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December 2018
2 Reads

Predictors of caregiver burden and care costs for older persons with dementia in Taiwan.

Int Psychogeriatr 2018 Dec 6:1-10. Epub 2018 Dec 6.

Department of Public Health,Kaohsiung Medical University,Kaohsiung,Taiwan.

ABSTRACTObjectives:As a degenerative disease, the progression of dementia needs continued care provision and poses both psychological and financial burden for family caregivers of persons with dementia (PWD). This study seeks to compare predictors of care costs and caregiver burden, and to identify modifiable factors that could alleviate the burden faced by dementia caregivers.

Methods: This study interviewed 231 PWD-caregiver dyads in a dementia clinic at a teaching hospital in southern Taiwan in 2013. Read More

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December 2018

Evaluation of macrolinguistic aspects of the oral discourse in patients with Alzheimer's disease.

Int Psychogeriatr 2018 Dec 6:1-11. Epub 2018 Dec 6.

Department of Speech Therapy,São Paulo Federal University,São Paulo,Brazil.

ABSTRACTIntroduction:Alzheimer's disease (AD) is a degenerative syndrome that impairs cognitive functioning, including speech and language. Discourse can be used to analyze language processing, which is organized into microlinguistic and macrolinguistic dimensions.

Objectives: To identify the occurrence of changes in the macrolinguistic dimension of oral discourse in AD patients. Read More

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December 2018
2 Reads

A Chemical Chaperone Decouples TDP-43 Disordered Domain Phase Separation from Fibrillation.

Biochemistry 2018 Dec 6. Epub 2018 Dec 6.

Ribonucleoprotein (RNP) condensations through liquid-liquid phase separation play vital roles in the dynamic formation-dissolution of stress granules (SGs). These condensations are, however, usually assumed to be linked to pathologic fibrillation. Here, we show that physiologic condensation and pathologic fibrillation of RNPs are independent processes that can be unlinked with the chemical chaperone trimethylamine N-oxide (TMAO). Read More

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December 2018

Opioid Use is Associated with Higher Severity-Adjusted Episode Costs in Patients with Conservatively Managed Degenerative Joint Disease of the Back and Neck.

Pharmacoeconomics 2018 Dec 6. Epub 2018 Dec 6.

Clinical Data Services and Analytics, UnitedHealthcare, 9700 Health Care Lane, Minnetonka, MN, 55343, USA.

Background: Opioid use and misuse are urgent health issues. Previous studies suggest that opioid use increases healthcare resource use but severity adjustment is lacking.

Objective: The objective of this study was to evaluate the severity-adjusted cost difference between opioid users and non-users among patients with conservatively managed degenerative joint disease of the spine within a large commercial health plan population in the United States. Read More

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December 2018
1 Read

Correlation of Optical Coherence Tomography and Retinal Histology in Normal and Pro23His Retinal Degeneration Pig.

Transl Vis Sci Technol 2018 Nov 30;7(6):18. Epub 2018 Nov 30.

Carver College of Medicine, Department of Ophthalmology and Visual Sciences, Institute for Vision Research, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA.

Purpose: We correlate optical coherence tomography (OCT) retinal layer thickness measurements with histology in wild-type and retinal degenerative pigs.

Methods: OCT scans were obtained using the Bioptigen Envisu R2200. In normal pigs, three eyes were imaged in vivo, and three eyes were imaged after enucleation. Read More

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November 2018
2 Reads

Myocardial fibrosis predicts adverse outcome after MitraClip implantation.

Catheter Cardiovasc Interv 2018 Dec 3. Epub 2018 Dec 3.

Department of Cardiology, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Heart Center, University of Amsterdam, Amsterdam, The Netherlands.

Background: High-risk patients with mitral regurgitation (MR) may be treated by a percutaneous mitral valve repair with the MitraClip, but identification of patients who may benefit remains difficult. We aimed to determine whether myocardial fibrosis predicts outcome in MR patients undergoing MitraClip implantation and is beneficial in clinical decision making.

Methods: Preprocedural to the MitraClip implantation, myocardial fibrosis was analyzed with cardiovascular magnetic resonance (CMR) through late gadolinium enhancement. Read More

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December 2018

The pequi pulp oil (Caryocar brasiliense Camb.) provides protection against aging-related anemia, inflammation and oxidative stress in Swiss mice, especially in females.

Genet Mol Biol 2018 Nov 29. Epub 2018 Nov 29.

Departmento de Genética e Morfologia, Instituto de Ciências Biologicas, Universidade de Brasília, Brasilia, DF, Brazil.

Continued exposure to reactive oxygen species and inflammation are the rationale behind aging theories and associated diseases. Scientific evidence corroborates the ethnomedicinal use of the oil of pequi (Caryocar brasiliense Camb.), a typical Brazilian Cerrado fruit, against oxidative damage to biomolecules and inflammation. Read More

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November 2018
6 Reads

Isolation, Characterization and MicroRNA-based Genetic Modification of Human Dental Follicle Stem Cells.

J Vis Exp 2018 Nov 16(141). Epub 2018 Nov 16.

Department of Operative Dentistry and Periodontology, Rostock University Medical Center.

To date, several stem cell types at different developmental stages are in the focus for the treatment of degenerative diseases. Yet, certain aspects, such as initial massive cell death and low therapeutic effects, impaired their broad clinical translation. Genetic engineering of stem cells prior to transplantation emerged as a promising method to optimize therapeutic stem cell effects. Read More

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November 2018
3 Reads

Comparison of scapular muscle activation during shoulder elevation in older and young adults: A pilot study.

J Back Musculoskelet Rehabil 2018 Nov 16. Epub 2018 Nov 16.

Department of Health Science, Korea University Graduate School, Seoul, Korea.

Background: The prevalence of degenerative shoulder disease is increasing, and most shoulder diseases are accompanied by changed activation of the scapular muscles. However, the characteristics of scapular muscle activation in older adults have not yet been reported.

Objective: The aim of this study was to investigate the effect of age and load on scapular muscle activation during shoulder abduction and flexion. Read More

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November 2018

Cryptotanshinone inhibits RANKL-induced osteoclastogenesis by regulating ERK and NF-κB signaling pathways.

J Cell Biochem 2018 Dec 2. Epub 2018 Dec 2.

Department of Orthopedics, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

Osteoporosis (OS) is one of the most common healthy problems characterized by low bone mass. Osteoclast, the primary bone-resorbing cell, is responsible for destructive bone diseases including osteoporosis (OS). Cryptotanshinone (CTS), an active component extracted from the root of Salvia miltiorrhiza bunge, has been shown to prevent the destruction of cartilage and the thickening of subchondral bone in mice osteoarthritis models. Read More

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December 2018

Intervertebral disc penetration by antibiotics used prophylactically in spinal surgery: implications for the current standards and treatment of disc infections.

Eur Spine J 2018 Dec 1. Epub 2018 Dec 1.

Central European Institute of Technology (CEITEC), Masaryk University, Kamenice 753/5, 625 00, Brno, Czech Republic.

Purpose: The presence of Propionibacterium acnes in a substantial component of resected disc specimens obtained from patients undergoing discectomy or microdiscectomy has led to the suggestion that this prominent human skin and oral commensal may exacerbate the pathology of degenerative disc disease. This hypothesis, therefore, raises the exciting possibility that antibiotics could play an important role in treating this debilitating condition. To date, however, little information about antibiotic penetration into the intervertebral disc is available. Read More

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December 2018
1 Read

The relevance of high-intensity zones in degenerative disc disease.

Int Orthop 2018 Nov 30. Epub 2018 Nov 30.

Department of Orthopaedics and Traumatology, The University of Hong Kong, Queen Mary Hospital, 5/F Professorial Block, Queen Mary Hospital, Pokfulam, Hong Kong SAR, China.

Purpose: The purpose of this study was to review the current understanding of high-intensity zones (HIZ) in the lumbar spine with particular attention to its imaging phenotype and clinical relevance.

Methods: A review was conducted of studies related to HIZ. Particular attention was made to imaging phenotypes and classification, and its relationship with discogenic low back pain (LBP). Read More

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November 2018
1 Read

The Prevalence of Cervical Foraminal Stenosis on Computed Tomography of a Selected Community-Based Korean Population.

Clin Orthop Surg 2018 Dec 21;10(4):433-438. Epub 2018 Nov 21.

Department of Orthopaedic Surgery, Daegu Catholic University Medical Center, Daegu, Korea.

Background: Cervical foraminal stenosis (CFS) is one of the degenerative changes of the cervical spine; however, correlations between the severity of stenosis and that of symptoms are not consistent in the literature. Studies to date on the prevalence of stenosis are based on images obtained from the departments treating cervical lesions, and thus patient selection bias may have occurred. The purpose of this study was to investigate the prevalence of CFS according to the site, extent, and morphology of stenosis using cervical computed tomography (CT) images obtained from patients who were visiting not because of symptoms related to the cervical spine, cervical pain, or upper limb pain. Read More

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December 2018

False-positive technetium-99m methylene diphosphonate bone scan activity in the orbit in a patient with a history of breast carcinoma.

World J Nucl Med 2018 Oct-Dec;17(4):299-301

Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO, USA.

Metastasis of breast carcinoma to the orbit is an uncommon entity and carries a poor prognosis. This case report presents false-positive technetium-99m methylene diphosphonate activity in the right orbit of a patient with a history of a primary breast neoplasm. Orbital computed tomography imaging was obtained to further characterize the radiotracer uptake identified on the bone scan and demonstrated diffuse right globe intraocular calcifications secondary to degenerative intraocular changes. Read More

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December 2018

All that glitters is not gold: sacroiliitis.

Reumatologia 2018 31;56(5):289-293. Epub 2018 Oct 31.

Department of Radiology, San Paolo Hospital, Bari, Italy.

Objectives: The aim of this study was to determine the prevalence of "rheumatic" and "non-rheumatic" changes of the sacro-iliac joints (SIJ).

Material And Methods: We performed MRI in 210 patients with suspected inflammatory low back pain. We sorted and analysed the characteristics of sacroiliac bone lesions in "rheumatic" and "non-rheumatic" patients and assessed the diagnostic values of their extent and location. Read More

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October 2018
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Usp16 modulates Wnt signaling in primary tissues through Cdkn2a regulation.

Sci Rep 2018 Nov 30;8(1):17506. Epub 2018 Nov 30.

Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, California, 94305, USA.

Regulation of the Wnt pathway in stem cells and primary tissues is still poorly understood. Here we report that Usp16, a negative regulator of Bmi1/PRC1 function, modulates the Wnt pathway in mammary epithelia, primary human fibroblasts and MEFs, affecting their expansion and self-renewal potential. In mammary glands, reduced levels of Usp16 increase tissue responsiveness to Wnt, resulting in upregulation of the downstream Wnt target Axin2, expansion of the basal compartment and increased in vitro and in vivo epithelial regeneration. Read More

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November 2018