69,399 results match your criteria Degenerative Lumbar Disc Disease in the Mature Athlete

Long Term Outcomes After Arthroscopic Transosseous Equivalent Repair: Clinical and MRI Results of Rotator Cuff Tears at a Minimum Follow-up of 10 Years.

J Shoulder Elbow Surg 2021 May 12. Epub 2021 May 12.

Department of Orthopedics and Traumatology, Koc University School of Medicine, Istanbul, Turkey. Electronic address:

Purpose: The objective of this study was to evaluate long-term functional outcomes and structural integrity of medium to massive rotator cuff tears at 10 to 12 years of follow-up after arthroscopic transosseous equivalent repair (TOE).

Methods: A retrospective view was performed on a consecutive series of patients who underwent primary arthroscopic TOE repair of medium to massive size degenerative rotator cuff tears by a single surgeon between January 2007 and August 2009. Patients were examined at a minimum follow-up of 10 years and magnetic resonance imaging (MRI) was performed to assess tendon integrity. Read More

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Role of coronoidectomy and temporalis myotomy in surgical management of oral submucous fibrosis.

Oral Maxillofac Surg 2021 May 15. Epub 2021 May 15.

Department of Oral pathology, SDM College of Dental Sciences and Hospital, A Constituent unit of Shri Dharmasthala Manjunatheshwara University, Dharwad, Karnataka, India.

Purpose: The involvement of temporalis muscle fibers by oral submucous fibrosis (OSMF) and the procedure of coronoidectomy and temporalis myotomy in the surgical treatment protocol for the disease is a controversy. The primary objective of this study is to evaluate the histopathological changes in temporalis muscle fibers in patients undergoing surgical treatment for OSMF and to authenticate the importance of temporalis myotomy and coronoidectomy in surgical treatment protocol.

Method: A 3-year prospective study was conducted to assess the histopathological changes in temporalis muscle in surgically treated OSMF cases. Read More

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Differentiation of inflammatory from degenerative changes in the sacroiliac joints by machine learning supported texture analysis.

Eur J Radiol 2021 May 11;140:109755. Epub 2021 May 11.

Institute of Diagnostic and Interventional Radiology, University Hospital Zurich, Raemistrasse 100, 8091 Zurich, Switzerland; Faculty of Medicine, University of Zurich, Switzerland.

Purpose: To compare the diagnostic performance of texture analysis (TA) against visual qualitative assessment in the differentiation of spondyloarthritis (SpA) from degenerative changes in the sacroiliac joints (SIJ).

Method: Ninety patients referred for suspected inflammatory lower back pain from the rheumatology department were retrospectively included at our university hospital institution. MRI at 3 T of the lumbar spine and SIJ was performed with oblique coronal T1-weighted (w), fluid-sensitive fat-saturated (fs) TIRM and fsT1w intravenously contrast-enhanced (CE) images. Read More

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Electric Neurostimulation Regulates Microglial Activation via Retinoic Acid Receptor α Signaling.

Brain Behav Immun 2021 May 11. Epub 2021 May 11.

Faculty of Medicine, Hebrew University of Jerusalem, Israel; The Department of Neurology, The Agnes Ginges Center for Human Neurogenetics, Hadassah - Hebrew University Medical Center, Jerusalem, Israel. Electronic address:

Brain stimulation by electroconvulsive therapy is effective in neuropsychiatric disorders by unknown mechanisms. Microglial toxicity plays key role in neuropsychiatric, neuroinflammatory and degenerative diseases. We examined the mechanism by which electroconvulsive seizures (ECS) regulates microglial phenotype and response to stimuli. Read More

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Optimizing Timing of Valve intervention in Asymptomatic Severe Valvular Heart Disease.

Can J Cardiol 2021 May 11. Epub 2021 May 11.

Department of Cardiology, Montreal Heart Institute, Montreal, Canada. Electronic address:

The management of valvular heart disease (VHD) has changed dramatically over the past decade with advances in cardiac imaging, the use of novel biomarkers and the development of transcatheter valve repair and replacement technology. International society guidelines have kept pace to provide recommendations for diagnosis, follow up and timing of intervention. The most challenging patient cohort for clinicians are patients with asymptomatic severe disease in whom the optimal timing of intervention can be ill-defined. Read More

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Lumbar Disc Herniation is a Nonnegligible Factor for the Degeneration of Sacroiliac Joints.

Pain Physician 2021 May;24(3):E357-E365

Department of Rheumatology and Immunology, Guangdong Second Provincial General Hospital, China; The Second School of Clinical Medicine, Southern Medical University, China.

Background: Sacroiliac joint (SIJ) abnormality is a potential source of low back pain (LBP), therefore numerous patients receive various treatments because of the degenerative changes of SIJ. However, the outcome is unfavorable for patients because these morphologic alterations are common but not the origins of LBP. Previous studies revealed lumbar fusion and transitional vertebra increased the prevalence of degeneration of SIJ. Read More

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Use of Bone Marrow Concentrate to Treat Pain and Musculoskeletal Disorders: An Academic Delphi Investigation.

Pain Physician 2021 May;24(3):263-273

Research & Development, Regenexx, LLC.

Background: Acute and degenerative musculoskeletal disorders are among the most common etiologies of disability worldwide. Recently, there has been interest in the field of regenerative medicine to bridge the gap between conservative and surgical management of these conditions. Autologous bone marrow concentrate is one type of injectate that has increased in popularity over the last few decades. Read More

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A small-molecule Psora-4 acts as a caloric restriction mimetic to promote longevity in C. elegans.

Geroscience 2021 May 14. Epub 2021 May 14.

Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117608, Singapore.

In populations around the world, the fraction of humans aged 65 and above is increasing at an unprecedented rate. Aging is the main risk factor for the most important degenerative diseases and this demographic shift poses significant social, economic, and medical challenges. Pharmacological interventions directly targeting mechanisms of aging are an emerging strategy to delay or prevent age-dependent diseases. Read More

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