19,444 results match your criteria Defibrillation and Cardioversion


Polyethylene glycol-20k reduces post-resuscitation cerebral dysfunction in a rat model of cardiac arrest and resuscitation: A potential mechanism.

Biomed Pharmacother 2021 May 1;139:111646. Epub 2021 May 1.

Department of Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, 277 Yanta West Street, Xi'an, Shaanxi 710061, China; Weil Institute of Emergency and Critical Care Research, Virginia Commonwealth University, Richmond, VA, USA; Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, VA, USA. Electronic address:

Out-of-hospital cardiac arrest (CA) is a leading cause of death in the United States. Severe post-resuscitation cerebral dysfunction is a primary cause of poor outcome. Therefore, we investigate the effects of polyethylene glycol-20k (PEG-20k), a cell impermeant, on post-resuscitation cerebral function. Read More

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Defibrillation Safety Margin Testing in Patients With Congenital Heart Disease: Results From the NCDR.

JACC Clin Electrophysiol 2021 Apr 22. Epub 2021 Apr 22.

Section of Cardiac Electrophysiology, Division of Cardiology, University of California-San Diego, La Jolla, California, USA.

Objectives: This study analyzed the predictors of defibrillation safety margin (DSM) testing at the time of implantable cardioverter-defibrillator (ICD) insertion and factors associated with inadequate DSM in patients with congenital heart disease (CHD).

Background: There are few data about the prevalence and safety of DSM testing in those with CHD.

Methods: A retrospective analysis was performed of all patients with atrial or ventricular septal defect, tetralogy of Fallot, transposition of the great vessels, Ebstein anomaly, or common ventricle undergoing a transvenous ICD procedure in the National Cardiovascular Data Registry (NCDR) ICD Registry from April 2010 to March 2016, and DSM testing was assessed. Read More

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Fast hypothermia induced by extracorporeal circuit cooling alleviates renal and intestinal injury after cardiac arrest in swine.

Am J Emerg Med 2021 Apr 23;47:231-238. Epub 2021 Apr 23.

Hangzhou Emergency Medical Center of Zhejiang Province, Zhejiang, Hangzhou, China. Electronic address:

Background: Continuous renal replacement therapy (CRRT) was currently demonstrated to be an effective way to induce fast hypothermia and had proective effects on cardiac dysfunction and brain damage after cardiac pulmonary resuscitation (CPR). In the present study, we aimed to investigate the influence of extracorporeal circuit cooling using CRRT on renal and intestinal damage after CPR based on a porcine model.

Methods: 32 pigs were subjected to ventricular fibrillation for 8 min, followed by CPR for 5 min before defibrillation. Read More

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Ventricular Fibrillation Recurrences in Successfully Shocked Out-of-Hospital Cardiac Arrests.

Medicina (Kaunas) 2021 Apr 7;57(4). Epub 2021 Apr 7.

Department of Biomedical Science and Public Health, Cardiology and Arrhythmology Clinic, University Hospital "Ospedali Riuniti Umberto I-Lancisi-Salesi", Marche Polytechnic University, 60020 Ancona, Italy.

The prognostic impact of ventricular fibrillation (VF) recurrences after a successful shock in out-of-hospital cardiac arrest (OOHCA) is still poorly understood, and some evidence suggests a potential pro-arrhythmic effect of chest compressions in this setting. In the present analysis, we looked at the short-term and long-term prognosis of VF recurrences in OOHCA. And their potential association with chest compressions. Read More

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Out of hospital sudden death in a rural population: Low rates of icd underutilization among decedents.

Pacing Clin Electrophysiol 2021 Apr 28. Epub 2021 Apr 28.

Department of Psychology and Cardiovascular Disease at East Carolina University, Greenville, North Carolina.

Background: Implantable cardioverter defibrillators (ICDs) reduce mortality in patients at risk for life-threatening arrhythmias. Implantation of ICDs in rural or economically disadvantaged populations is suspected to be low. This study examined Out of Hospital Premature Natural Death (OHPND) and electronic medical record (EMR) data to identify rates of non-implantation of ICDs among decedents in eastern North Carolina. Read More

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Technical Aspects of Intensive Care Unit Management: A Single-Center Experience at a Tertiary Academic Hospital.

J Multidiscip Healthc 2021 20;14:869-875. Epub 2021 Apr 20.

Prince Abdullah Ben Khalid Celiac Disease Research Chair, King Saud University, Riyadh, Saudi Arabia.

Purpose: Special technical issues associated with the function and maintenance of medical devices arise in intensive care units (ICUs). This study explored the level of comfort of ICU staff in dealing with selected equipment, the factors that are associated with the staff's ease of adaptation to new technologies, and the role of technical support staff.

Patients And Methods: This is a single-center cross-sectional questionnaire-based survey that was conducted in February 2018 and targeted nurses working in the ICUs of King Saud University Medical City in Riyadh, Saudi Arabia. Read More

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Cardiac arrhythmias in patients with COVID-19: Lessons from 2300 telemetric monitoring days on the intensive care unit.

J Electrocardiol 2021 Apr 16;66:102-107. Epub 2021 Apr 16.

DZHK (German Center of Cardiovascular Research), partner site Berlin, Germany; Department of Internal Medicine and Cardiology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.

Background: Patients with COVID-19 seem to be prone to the development of arrhythmias. The objective of this trial was to determine the characteristics, clinical significance and therapeutic consequences of these arrhythmias in COVID-19 patients requiring intensive care unit (ICU) treatment.

Methods And Results: A total of 113 consecutive patients (mean age 64. Read More

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Assessment of the knowledge level and experience of healthcare personnel concerning CPR and early defibrillation: an internal survey.

BMC Cardiovasc Disord 2021 Apr 20;21(1):195. Epub 2021 Apr 20.

Department of Anesthesia and Intensive Care, University of Pisa, Via Paradisa 2, 56124, Pisa, Italy.

Background: In-hospital cardiac arrest (IHCA) is a major public health problem with significant mortality. Rapid cardiopulmonary resuscitation and early defibrillation is extremely connected to patient outcome. In this study, we aimed to assess the effects of a basic life support and defibrillation course in improving knowledge in IHCA management. Read More

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Effects of Preoperative Statin on the Frequency of Ventricular Fibrillation and C-Reactive Protein Level in Patients Undergoing Isolated Coronary Artery Bypass Grafting.

J Coll Physicians Surg Pak 2021 Apr;30(4):373-378

Department of Cardiovascular Surgery, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey.

Objective: To investigate the effects of statin use in preoperative period on the development of ventricular fibrillation (VF) following the removal of aortic cross-clamp (ACC) and on the levels of inflammation biomarker C-reactive protein (CRP) in patients who undergo elective isolated coronary artery bypass grafting (CABG).

Study Design: Observational study.

Place And Duration Of Study: Department of Cardiovascular Surgery, Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey, between May 2019 and January 2020. Read More

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Adrenaline to improve survival in out-of-hospital cardiac arrest: the PARAMEDIC2 RCT.

Health Technol Assess 2021 Apr;25(25):1-166

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry, UK.

Background: Adrenaline has been used as a treatment for cardiac arrest for many years, despite uncertainty about its effects on long-term outcomes and concerns that it may cause worse neurological outcomes.

Objectives: The objectives were to evaluate the effects of adrenaline on survival and neurological outcomes, and to assess the cost-effectiveness of adrenaline use.

Design: This was a pragmatic, randomised, allocation-concealed, placebo-controlled, parallel-group superiority trial and economic evaluation. Read More

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Out-of-hospital resuscitation of a 3 month old boy presenting with recurrent ventricular fibrillation cardiac arrest: a case report.

Scand J Trauma Resusc Emerg Med 2021 Apr 13;29(1):58. Epub 2021 Apr 13.

London Ambulance Service NHS Trust, London Ambulance Service, 220 Waterloo Road, London, SE1 8SD, UK.

A 3 month old boy, with no known health conditions, suffered a sudden collapse at home. On first EMS arrival, ventricular fibrillation (VF) cardiac arrest was identified and resuscitation following UK national guidelines was initiated. He remained in cardiac arrest for over 25 min, during which he received 10 defibrillation shocks, each effective, but with VF reoccurring within a few seconds of each of the first 9. Read More

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Association between the number of prehospital defibrillation attempts and neurologic outcomes in out-of-hospital cardiac arrest patients without on-scene return of spontaneous circulation.

Clin Exp Emerg Med 2021 Mar 31;8(1):21-29. Epub 2021 Mar 31.

Department of Emergency Medicine, Seoul National University Hospital, Seoul, Korea.

Objective: Delivery of prehospital defibrillation for shockable rhythms by emergency medical service providers is crucial for successful resuscitation in out-of-hospital cardiac arrest (OHCA) patients. The optimal range of prehospital defibrillation attempts for refractory shockable rhythms is unknown. This study evaluated the association between the number of prehospital defibrillation attempts and neurologic outcomes in OHCA patients. Read More

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Public awareness and willingness to use automated external defibrillators in a metropolitan city.

Clin Exp Emerg Med 2021 Mar 31;8(1):1-8. Epub 2021 Mar 31.

Department of Emergency Medicine, Dongguk University Ilsan Hospital, Dongguk University College of Medicine, Seoul, Korea.

Objective: Early defibrillation is crucial for the survival of patients with out-of-hospital cardiac arrest. This study aimed to examine the trends and associated factors regarding public awareness and willingness to use automated external defibrillators (AEDs) through citywide surveys.

Methods: Three-round surveys were conducted in February 2012 (n=1,000), December 2016 (n=1,141), and December 2018 (n=1,001) among citizens in Daegu, South Korea, who were aged ≥19 years. Read More

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Introducing Tb in (Ce/Eu)TbMoO Metal Oxide at Room Temperature and Its Use in Amyloid Defibrillation.

ACS Appl Mater Interfaces 2021 Apr 7;13(15):18184-18193. Epub 2021 Apr 7.

Department of Chemistry, National Sun Yat-Sen University, No. 70, Lien-Hai Road, Kaohsiung 804, Taiwan.

Tunable optical properties in nanomaterials enable a variety of applications in multidisciplinary areas. These properties are directly related to several different factors such as solvent conditions, synthesis methods, and most significantly, the oxidation states of metals participating in the absorption or emission properties. Lanthanide metals containing ABO perovskites are among such nanomaterials that can be tuned to a great extent by only modifying the charged states on the metals in the composition. Read More

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Early primary closure for device pocket infection.

Pacing Clin Electrophysiol 2021 Apr 5. Epub 2021 Apr 5.

Division of Cardiology, Cardiac Electrophysiology Program, University of California Medical Center, San Diego, California, USA.

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Novel Low-Voltage MultiPulse Therapy to Terminate Atrial Fibrillation.

JACC Clin Electrophysiol 2021 Mar 25. Epub 2021 Mar 25.

George Washington University, Washington, DC, USA. Electronic address:

Objectives: This first-in-human feasibility study was undertaken to translate the novel low-voltage MultiPulse Therapy (MPT) (Cardialen, Inc., Minneapolis, Minnesota), which was previously been shown to be effective in preclinical studies in terminating atrial fibrillation (AF), into clinical use.

Background: Current treatment options for AF, the most common arrhythmia in clinical practice, have limited success. Read More

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Surviving cardiac arrest: What happens after admission to the intensive care unit?

Rev Port Cardiol 2021 May 31;40(5):317-325. Epub 2021 Mar 31.

CINTESIS - Center for Health Technology and Services Research, Portugal; Anesthesiology Department, Centro Hospitalar Universitário São João, Porto, Portugal; Surgery and Physiology Department, Faculty of Medicine of Porto, Porto, Portugal.

Introduction: Patients successfully resuscitated from cardiac arrest (CA) are admitted to the intensive care unit (ICU) for post-resuscitation care. These patients' prognosis remains dismal, with only a minority surviving to hospital discharge. Understanding the clinical factors involved in the management of these patients is essential to improve their prognosis. Read More

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Use of Public Automated External Defibrillators in Out-of-Hospital Cardiac Arrest in Poland.

Medicina (Kaunas) 2021 Mar 22;57(3). Epub 2021 Mar 22.

Department of Internal and Pediatric Nursing, Faculty of Health Sciences, Medical University of Gdańsk, 80-211 Gdańsk, Poland.

National medical records indicate that approximately 350,000-700,000 people die each year from sudden cardiac arrest. The guidelines of the European Resuscitation Council (ERC) and the International Liaison Committee on Resuscitation (ILCOR) indicate that in addition to resuscitation, it is important-in the case of so-called defibrillation rhythms-to perform defibrillation as quickly as possible. The aim of this study was to assess the use of public automated external defibrillators in out of hospital cardiac arrest in Poland between 2008 and 2018. Read More

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Optimizing defibrillation during cardiac arrest.

Curr Opin Crit Care 2021 Jun;27(3):246-254

Department of Anesthesiology, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico.

Purpose Of Review: Current cardiac arrest guidelines are based on a fixed, time-based defibrillation strategy. Rhythm analysis and shock delivery (if indicated) are repeated every 2 min requiring cyclical interruptions of chest compressions. This approach has several downsides, such as the need to temporarily stop cardiopulmonary resuscitation (CPR) for a variable amount of time, thus reducing myocardial perfusion and decreasing the chance of successful defibrillation. Read More

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Evidence-based defibrillation dosage for children: Is it feasible to power a reliable pediatric clinical trial or it is mission impossible?

Resuscitation 2021 May 29;162:266-267. Epub 2021 Mar 29.

Life Support and Medical Simulation Research Group, Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain; CLINURSID Research Group, University of Santiago de Compostela, Santiago de Compostela, Spain; Paediatric Intensive Care Unit, Intermediate and Palliative Care Section, Paediatric Area, Clinic University Hospital of Santiago de Compostela (CHUS), Galician Public Health System (SERGAS), Santiago de Compostela, Spain.

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Clinical dilemma of management: Cardiac arrest after microsclerotherapy for lower limb telangiectasia with liquid 0.3% aethoxysklerol or idiopathic cardiac arrest?

SAGE Open Med Case Rep 2021 9;9:2050313X211000866. Epub 2021 Mar 9.

The Whiteley Clinic, Guildford, UK.

A 48-year-old woman attended to discuss a dilemma. She had suffered a cardiac arrest immediately following microsclerotherapy of leg telangiectasia with 0.3% aethoxysklerol. Read More

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Cardiac operations and interventions during the COVID-19 pandemic: a nationwide perspective.

Europace 2021 Mar 29. Epub 2021 Mar 29.

Department of Cardiology, Aston Medical School, Aston University, Birmingham B4 7ET, UK.

Aims : The COVID-19 pandemic has led to a decline in hospitalizations for non-COVID-19-related conditions. We explored the impact of the COVID-19 pandemic on cardiac operations and interventions undertaken in England.

Methods And Results : An administrative database covering hospital activity for England, the Health Episodes Statistics, was used to assess a total of 286 697 hospitalizations for cardiac operations and interventions, as well as 227 257 hospitalizations for myocardial infarction (MI) and 453 799 for heart failure (HF) from 7 January 2019 to 26 July 2020. Read More

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Use of Simulation-Based Medical Education for Advanced Resuscitation of In-Hospital Cardiac Arrest Patients with Suspected or Confirmed COVID-19.

Can J Cardiol 2021 Mar 25. Epub 2021 Mar 25.

Montreal Heart Institute, Montreal, Canada.

Cardiac arrest is common in critically-ill patients with coronavirus disease 2019 (COVID-19) and is associated with poor survival. Simulation is frequently used to evaluate and train code teams with the goal of improving outcomes. All participants engaged in a training on personal protective equipment donning and doffing for suspected or confirmed COVID-19 cases. Read More

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Rapid dispatch for out-of-hospital cardiac arrest is associated with improved survival.

Resuscitation 2021 Mar 26. Epub 2021 Mar 26.

Department of Cardiology, Nordsjællands Hospital, Dyrehavevej 29, 3400 Hillerød, Denmark; Department of Cardiology, Aalborg University Hospital, Hobrovej 18-22, 9000 Aalborg, Denmark.

Aim: As proxy for initiation of the first link in the Chain of Survival by the dispatcher, we aimed to investigate the effect of time to first dispatch on 30-day survival among patients with OHCA ultimately receiving the highest-level emergency medical response.

Methods: We linked data on all OHCA unwitnessed by emergency medical services (EMS) treated by Copenhagen EMS from 2016 through 2018 to corresponding emergency call records. Among patients receiving highest priority emergency response, we calculated time to dispatch as time from start of call to time of first dispatch. Read More

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European Resuscitation Council Guidelines 2021: Basic Life Support.

Resuscitation 2021 Apr 24;161:98-114. Epub 2021 Mar 24.

Warwick Clinical Trials Unit, Warwick Medical School, University of Warwick, Coventry CV4 7AL, United Kingdom; University Hospitals Birmingham, Birmingham B9 5SS, United Kingdom.

The European Resuscitation Council has produced these basic life support guidelines, which are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. The topics covered include cardiac arrest recognition, alerting emergency services, chest compressions, rescue breaths, automated external defibrillation (AED), CPR quality measurement, new technologies, safety, and foreign body airway obstruction. Read More

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European Resuscitation Council Guidelines 2021: Paediatric Life Support.

Resuscitation 2021 Apr 24;161:327-387. Epub 2021 Mar 24.

Paediatric Emergency Medicine, Imperial College Healthcare Trust NHS, Faculty of Medicine Imperial College, London, UK.

These European Resuscitation Council Paediatric Life Support (PLS) guidelines, are based on the 2020 International Consensus on Cardiopulmonary Resuscitation Science with Treatment Recommendations. This section provides guidelines on the management of critically ill infants and children, before, during and after cardiac arrest. Read More

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Strategies on locations of public access defibrillator: A systematic review.

Am J Emerg Med 2021 Feb 27;47:52-57. Epub 2021 Feb 27.

Department of Emergency Medicine, National Taiwan University Hsin-Chu Hospital, Hsinchu City, Taiwan, R.O.C.; Department of Emergency Medicine, National Taiwan University Hospital, Taipei City, Taiwan, R.O.C.. Electronic address:

Background: Out-of-hospital cardiac arrest (OHCA) is a critical condition with poor outcomes. Although the survival rate increases in those who undergo defibrillation, the utility of on-time defibrillation among bystanders remained low. An evaluation of the deployment strategy for public access defibrillators (PADs) is necessary to increase their use and accessibility. Read More

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February 2021

Activation of citizen responders to out-of-hospital cardiac arrest.

Curr Opin Crit Care 2021 Jun;27(3):209-215

Copenhagen Emergency Medical Services, University of Copenhagen.

Purpose Of Review: To discuss different approaches to citizen responder activation and possible future solutions for improved citizen engagement in out-of-hospital cardiac arrest (OHCA) resuscitation.

Recent Findings: Activating volunteer citizens to OHCA has the potential to improve OHCA survival by increasing bystander cardiopulmonary resuscitation (CPR) and early defibrillation. Accordingly, citizen responder systems have become widespread in numerous countries despite very limited evidence of their effect on survival or cost-effectiveness. Read More

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Automatic external defibrillator provided by unmanned aerial vehicle (drone) in Greater Paris: A real world-based simulation.

Resuscitation 2021 May 22;162:259-265. Epub 2021 Mar 22.

Emergency Medical Department, Paris Fire Brigade, 1, Place Jules Renard, 75017 Paris, France.

Aim: To reduce the delay in defibrillation of out-of-hospital cardiac arrest (OHCA) patients, recent publications have shown that drones equipped with an automatic external defibrillator (AED) appear to be effective in sparsely populated areas. To study the effectiveness of AED-drones in high-density urban areas, we developed an algorithm based on emergency dispatch parameters for the rate and detection speed of cardiac arrests and technical and meteorological parameters.

Methods: We ran a numerical simulation to compare the actual time required by the Basic Life Support team (BLSt) for OHCA patients in Greater Paris in 2017 to the time required by an AED-drone. Read More

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