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Eur Heart J Case Rep 2021 Apr 21;5(4):ytab120. Epub 2021 Apr 21.

Department of cardiology, Heart Centre OLVG, Oosterparkstraat 9, 1091 AC Amsterdam, the Netherlands.

Background: Non-bacterial thrombotic endocarditis (NBTE) is a rare form of endocarditis notably described in patients with advanced malignancy and auto-immune diseases. It is characterized by the formation of sterile, fibrin-containing vegetations on cardiac endothelium, in the absence of positive blood cultures. It is predominantly located on the mitral- and aortic valve (AV). Read More

J Vasc Surg Venous Lymphat Disord 2021 Jun 3. Epub 2021 Jun 3.

Department of Surgery, Northwest Clinics, Alkmaar, the Netherlands.

Objective: To review and analyse the currently available literature on Flebogrif and define its role in the global varicose vein treatment devices market.

Methods: A systematic literature search was performed in MEDLINE, Embase, and the Cochrane Library. Studies were eligible if they included patients treated with Flebogrif for saphenous vein incompetence, were published in English, and had full text available. Read More

Minerva Med 2021 05 14. Epub 2021 May 14.

Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

Lemierre syndrome is a rare form of septic thrombophlebitis of the head and neck veins, most typically the internal jugular vein, which affects otherwise healthy adolescents and young adults after an oropharyngitis or other local infection and is characterized by multiple septic embolization. Despite treatment, Lemierre syndrome displays a high rate of in-hospital complications that include thrombus progression and new peripheral septic embolization, and it can be fatal or cause disabling sequelae. The mainstay of treatment is antibiotic therapy; anticoagulation is often used, but its role is controversial. Read More

Semin Thromb Hemost 2021 May 10. Epub 2021 May 10.

Division of Cardiovascular Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Isolated distal deep vein thrombosis (IDDVT) is presumed to be more benign than proximal DVT (PDVT) or pulmonary embolism (PE), suggesting a need for different management approaches. This subgroup analysis of the RE-COVERY DVT/PE global, observational study investigated patient characteristics, hospitalization details, and anticoagulant therapy in patients with IDDVT in real-world settings in 34 countries enrolled from January 2016 to May 2017. Data were analyzed descriptively according to the type and location of the index venous thromboembolism (VTE): IDDVT, PDVT ± distal DVT (DDVT), and PE ± DVT. Read More

Pract Neurol 2021 May 7. Epub 2021 May 7.

Department of Neurology, Leeds Centre for Neurosciences, Leeds General Infirmary, Leeds, West Yorkshire, UK.

Lemierre's syndrome is a rare and potentially life-threatening condition that follows an oropharyngeal infection, typically from and usually affects healthy adolescents or young adults. The characteristic features are septic thrombophlebitis of the internal jugular vein and septic embolism leading to multiorgan involvement, commonly the brain, lungs and bones. We report a man with presenting symptoms suggesting hemicrania continua, whose initial imaging showed no features of dural venous sinus or jugular thrombosis. Read More

Case Rep Crit Care 2021 9;2021:5544505. Epub 2021 Apr 9.

Staten Island University Hospital, Staten Island, NY 10305, USA.

Background: Central venous catheters (CVCs) have been frequently associated with septic thrombophlebitis, bacteremia, and septic emboli. Right-sided infective endocarditis is seen concurrently in patients with septic pulmonary emboli. A case of methicillin-resistant Staphylococcus aureus (MRSA) bacteremia and septic pulmonary emboli secondary to infected peripheral venous catheter (PVC) is reported. Read More

Vasc Med 2021 Apr 8:1358863X211000420. Epub 2021 Apr 8.

Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

Mondor disease is characterized by an acute painful thrombophlebitis occurring at specific anatomical sites. Data on its incidence, characteristics of clinical presentation, and course are unavailable to date. We studied the course of Mondor disease in patients diagnosed and followed at the University Hospital Zurich (Switzerland) between 2004 and 2020. Read More

Acta Ophthalmol 2021 Apr 8. Epub 2021 Apr 8.

Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

Purpose: Lemierre syndrome is a life-threatening condition characterized by head/neck bacterial infection, local suppurative thrombophlebitis and septic embolic complications in a range of sites of distant organs. No prior study focused on the course and characteristics of ophthalmic complications of Lemierre syndrome.

Methods: We analysed data of 27 patients with ophthalmic complications from a large cohort of 712 cases with Lemierre syndrome reported globally between 2000 and 2017. Read More

J Med Case Rep 2021 Apr 2;15(1):188. Epub 2021 Apr 2.

Surgery Department, Mohamed Taher El Maamouri Hospital, Nabeul, Tunisia.

Background: Mondor's disease of the breast (MDB) is a rare and benign disorder of the breast. It is characterized by thrombophlebitis of the superficial veins of the chest wall. Clinically, it manifests as a cord-like induration of the breast area. Read More

Laryngorhinootologie 2021 04 30;100(4):291-293. Epub 2021 Mar 30.

Department of Radiology, University Hospital Gießen, Gießen, Germany.

Acute Med 2021 ;20(1):78-82

MB, BCh, BAO, FRCP, PhD, Acute Medicine Unit, Wards 7B and 7C, Royal Victoria Hospital, Belfast.

We present the case of a previously healthy, immunocompetent male with Lemierre's Syndrome. He presented with headache, sore throat and pyrexia. Initial blood tests revealed raised inflammatory markers and electrolyte abnormalities. Read More

BMJ Case Rep 2021 Mar 17;14(3). Epub 2021 Mar 17.

The Ear, Nose and Throat Department, Maidstone and Tunbridge Wells NHS Trust, Maidstone, Kent, UK.

A 43-year-old woman was referred to the Ear, Nose and Throat Department with a 3-day history of left-sided neck pain and swelling associated with fevers and night sweats. She also reported a cough, oral thrush and a dental extraction more than a month previously. A CT scan of the neck with contrast revealed left internal jugular vein (IJV) thrombophlebitis and the patient was initially managed for suspected Lemierre's syndrome. Read More

Hautarzt 2021 Apr 17;72(4):307-313. Epub 2021 Mar 17.

Hautklinik, Universitätsklinikum Aachen, Pauwelsstr. 30, 52074, Aachen, Deutschland.

In contrast to the obligatory paraneoplasias, which are usually rare, diseases such as Sweet's syndrome, thrombophlebitis or herpes zoster are more common. But they are less frequently associated with neoplasia. The risk of overlooking an associated neoplasm is therefore greater. Read More

BMJ Case Rep 2021 Mar 16;14(3). Epub 2021 Mar 16.

Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand

Lemierre's syndrome is a rare multisystemic infection beginning in oropharynx commonly caused by oral anaerobic organisms and leading to internal jugular vein thrombosis with septic emboli. Here, we describe a 45-year-old woman with hypertension and unrecognised type 2 diabetes who presented to a community hospital with fever, double vision and septic shock. Examination showed neck pain aggravated by neck flexion, limited ocular movement of right lateral rectus, left medial rectus and left superior oblique and incomplete ptosis of the left eye. Read More

Thromb Res 2021 06 6;202:36-39. Epub 2021 Mar 6.

Center for Thrombosis and Hemostasis, University Medical Center Mainz, Mainz, Germany; Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland. Electronic address:

Stem Cells Int 2021 23;2021:8816763. Epub 2021 Feb 23.

Department of Vascular Surgery, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.

Background: Vascular adventitia contains progenitor cells and is shown to participate in vascular remolding. Progenitor cells are recruited into the venous thrombi in mice to promote neovascularization. We hypothesized that the adventitial progenitor cells of human great saphenous vein (HGSV-AdPC) enhance the resolution of venous thrombosis via neovascularization. Read More

Medicine (Baltimore) 2021 Feb;100(8):e24632

Department of Emergency Medicine.

Rationale: Postpartum ovarian vein thrombophlebitis (POVT) is a rare condition, and it can lead to severe complications and mortality. Here we report a patient who presented with vaginal bleeding and the diagnosis of POVT was confirmed by imaging.

Patient Concerns: A 38-year-old postpartum woman without remarkable medical history presented with vaginal bleeding and lower abdominal pain. Read More

J Neurosurg Pediatr 2021 Feb 26:1-7. Epub 2021 Feb 26.

Departments of1Pediatrics.

Objective: The management of hydrocephalus resulting from intraventricular hemorrhage related to extreme prematurity remains demanding. Given the complexities of controlling hydrocephalus in this population, less commonly used procedures may be required. The authors examined the utility of ventriculogallbladder (VGB) shunts in a series of such children. Read More

Handb Clin Neurol 2021 ;177:261-267

Department of Neurology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL, United States. Electronic address:

Patients with neurologic disease are at high risk of venous thromboembolism (VTE). The converse risk of neurological complications in concert or following peripheral VTE is rarely considered. The major neurologic complication following pulmonary embolism or peripheral VTE is intracranial hemorrhage that occurs following anticoagulation therapy for VTE. Read More

Clin Nucl Med 2021 Feb 20. Epub 2021 Feb 20.

Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany Clinic of Angiology, University Hospital Zurich, Zurich, Switzerland.

Int J Cardiol 2021 05 30;331:221-229. Epub 2021 Jan 30.

Clinical Department of Medical, Surgical and Health Science, University of Trieste, Piazzale Europa, 1, 34127 Trieste, TS, Italy.

Background: Hughes-Stovin syndrome (HSS) is a systemic disease characterized by widespread vascular thrombosis and pulmonary vasculitis with serious morbidity and mortality. The HSS International Study Group is a multidisciplinary taskforce aiming to study HSS, in order to generate consensus recommendations regarding diagnosis and treatment.

Methods: We included 57 published cases of HSS (43 males) and collected data regarding: clinical presentation, associated complications, hemoptysis severity, laboratory and computed tomography pulmonary angiography (CTPA) findings, treatment modalities and cause of death. Read More

BMJ Case Rep 2021 Feb 1;14(2). Epub 2021 Feb 1.

Cardiology, West Hertfordshire Hospitals NHS Trust, Watford, UK.

A 49-year-old female patient presented with acute-on-chronic chest pain. She was diagnosed with multiple systemic thromboemboli, including myocardial infarctions, bilateral chronic pulmonary emboli, ischaemic stroke, deep venous thrombosis and superficial thrombophlebitis. She had a background of sickle cell trait. Read More

J Dermatol 2021 Apr 27;48(4):e159-e160. Epub 2021 Jan 27.

Department of Dermatology, Nara Medical University School of Medicine, Kashihara, Japan.

BMJ Case Rep 2021 Jan 20;14(1). Epub 2021 Jan 20.

Department of General Internal Medicine, Kokuho Asahi Chuo Hospital, Asahi, Chiba, Japan.

, which occurs as part of the oral microflora, is an uncommon cause of infection. However, it can cause serious bloodstream infections including infective endocarditis. Although oral bacteria, most commonly the spp, can cause internal jugular vein (IJV) thrombophlebitis, there are no reported cases of IJV thrombosis caused Here we report a patient with septic IJV thrombosis with bacteraemia. Read More

Orthop Surg 2021 Apr 19;13(2):442-450. Epub 2021 Jan 19.

Department of Orthopaedics, Southern Medical University, Guangzhou, China.

Objective: To analyze perioperative complications, resource consumption, and inpatient mortality of patients who receive total joint arthroplasty (TJA) with a concomitant diagnosis of a primary hypercoagulable state (PHS). The following questions were posed in the present paper. First, do patients undergoing TJA with PHS have increased risk of deep venous thrombosis (DVT), pulmonary embolism (PE), and periprosthetic joint infection (PJI)? Second, what other in-hospital complications are more likely among PHS patients undergoing TJA? Third, do TJA patients with PHS usually consume greater in-hospital resources? Fourth, do PHS patients suffer higher mortality rates compared to non-PHS patients? Finally, have PHS patients received proper anticoagulant management in past arthroplasties?

Methods: The National Inpatient Sample (NIS) database for the years between 2003 and 2014 was searched to identify patients undergoing primary TJA. Read More

Eur J Vasc Endovasc Surg 2021 Apr 14;61(4):627. Epub 2021 Jan 14.

Angiology and Vascular Surgery Department, Centro Hospitalar Universitário de São João, Porto, Portugal.

JBJS Case Connect 2020 12 4;10(4):e20.00362. Epub 2020 Dec 4.

Section of Orthopaedic Surgery, Department of Surgery, University of Calgary, Calgary, Alberta Canada.

Case: We present a 20-year-old female with Lemierre's syndrome and an associated infectious brachial plexopathy and missed septic shoulder arthritis. She subsequently presented with advanced post-infectious glenohumeral joint arthritis. At the final 12-month follow-up, substantial shoulder pain and dysfunction persisted. Read More

Mayo Clin Proc 2021 01;96(1):257-258

Department of Infectious Diseases, Infection Control and Employee Health, The University of Texas MD Anderson Cancer Center, Houston.

Int J Cardiol 2021 04 8;329:179-184. Epub 2020 Dec 8.

Department of Cardiology, Cardiology I, University Medical Center Mainz (Johannes Gutenberg-University Mainz), Mainz, Germany.

Background: Venous thromboembolism (VTE) constitute a major global burden of disease. Current international guidelines recommend treatment with anticoagulant therapy after VTE for a duration of at least 3 months. Since anticoagulation also imposes an increased risk for bleeding events, the individual risk has to be evaluated to determine adequate treatment plans. Read More

Praxis (Bern 1994) 2020 ;109(16):1271-1275

Medizinische Klinik Ospidal, Gesundheitszentrum Scuol.

A 'Trivial' Angina with Serious Consequences A 21-year old man presented with a septic shock two weeks after a pharyngitis. A thrombosis oft the internal jugular vein, septic systemic metastatic lesions and bacteriamia with Fusobacterium necrophorum led to the diagnosis of a Lemierre's syndrome - a rare complication of a pharyngitis with high morbidity and mortality, defined by a septic thrombophlebitis of the internal jugular vein with high risk of embolisation. A streptococcal-negative pharyngitis with red flags should therefore also be treated with antibiotics. Read More