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Clin Appl Thromb Hemost 2019 Jan-Dec;25:1076029619839150

2 Oakland University William Beaumont School of Medicine, Rochester, MI, USA.

Catheter-related (CR) thrombosis is a significant complication of midline catheters (MCs) and peripherally inserted central catheters (PICCs). Limited existing data for MCs suggest a favorable complication profile for MCs. To compare incidence of CR thrombosis between MCs and PICCs and to evaluate the impact of quantity of lumens and catheter diameter on CR thrombosis. Read More

Arch Med Sci 2019 Mar 4;15(2):393-401. Epub 2019 Mar 4.

Department of Vascular Disease, University Medical Centre Ljubljana, Ljubljana, Slovenia.

Introduction: Little is known about pathogenetic mechanisms of superficial venous thrombosis (SVT). We aimed to investigate the systemic inflammatory response in the acute phase of SVT, the time course of inflammatory markers and involvement of inflammation in resolution of thrombus in SVT.

Material And Methods: The circulatory inflammatory parameters high-sensitivity C-reactive protein (hsCRP), tumor necrosis factor α (TNF-α), interleukins 6, 8 and 10 (IL-6, IL-8, IL-10), and markers of fibrinolytic activity tissue plasminogen activator (t-PA), plasminogen activator inhibitor-1 (PAI-1) and fibrinogen were determined in 68 patients with acute SVT of lower limbs, who were allocated to two groups, dalteparin 5000 IU once daily or 10 000 IU once daily. Read More

N Engl J Med 2019 Mar;380(12):e16

University of Manitoba, Winnipeg, MB, Canada

Z Rheumatol 2019 Mar 14. Epub 2019 Mar 14.

Faculty of Behavioral, Management and Social Sciences, Department Psychology, Health and Technology, University of Twente, Enschede, The Netherlands.

Hughes-Stovin syndrome (HSS), characterized by the combination of multiple pulmonary artery aneurysms and deep vein thrombosis, is a rare and an under-recognized clinical entity with less than 40 published cases in English medical literature. Vascular venous thrombotic events, as occurring in the course of Behçet's disease (BD), are also described in HSS, e. g. Read More

Indian J Pharmacol 2018 Nov-Dec;50(6):344-349

Department of Anaesthesia and Intensive Care, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Objectives: Thrombosis and thrombophlebitis of the superficial venous system are common in hospitalized patients. Efficacy and safety of topical quick penetrating solution (QPS) of heparin were compared to heparin sodium topical gel for the prevention of infusion-associated phlebitis.

Materials And Methods: Patients aged 18-65 years undergoing intravenous cannulation for at least 72 h were enrolled and randomized to receive 6-8 drops of topical solution of heparin (Group sodium topical solution [QPS]) or1 g of topical gel (Group GEL) over the cannulated vein every 8 hourly for a total of 10 doses. Read More

Am Surg 2019 Jan;85(1):e47-e49

J Tehran Heart Cent 2018 Jul;13(3):132-135

Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

Inferior vena cava (IVC) thrombosis is a rare medical condition. Suppurative thrombophlebitis of the IVC is even a more uncommon subtype of IVC thrombosis and is mostly associated with IVC filters or venous catheters. We describe a 66-year-old man with persistent fever and history of pyonephrosis secondary to transurethral lithotripsy 1 month before recent admission. Read More

Clin Lymphoma Myeloma Leuk 2018 Dec 20. Epub 2018 Dec 20.

Department of Clinical Medicine and Surgery, Federico II University Medical School, Naples, Italy.

Background: The incidence of peripherally inserted central catheter (PICC)-related adverse events has been uncertain in the setting of acute myeloid leukemia (AML) compared with the incidence of centrally inserted central catheter (CICC) adverse events.

Patients And Methods: We conducted a monocentric, randomized trial of patients with previously untreated AML. Of the 93 patients, 46 had received a PICC and 47 had received a CICC as frontline intravascular device. Read More

Cochrane Database Syst Rev 2019 01 23;1:CD007798. Epub 2019 Jan 23.

National Centre of Research Excellence in Nursing, Centre for Health Practice Innovation, Menzies Health Institute Queensland, Griffith University, 170 Kessels Road, Brisbane, Queensland, Australia, 4111.

Background: US Centers for Disease Control guidelines recommend replacement of peripheral intravenous catheters (PIVC) no more frequently than every 72 to 96 hours. Routine replacement is thought to reduce the risk of phlebitis and bloodstream infection. Catheter insertion is an unpleasant experience for patients and replacement may be unnecessary if the catheter remains functional and there are no signs of inflammation or infection. Read More

Blood Coagul Fibrinolysis 2019 Mar;30(2):80-84

Laboratorio de Hematología, Sanatorio Allende.

: Hypodysfibrinogenemia and protein C deficiency are coagulopathies and in this report, we describe a young patient with both defects confirmed by molecular genetic tests. The patient was a 24-year-old woman referred for recurrent thrombophlebitis and finally deep venous thrombosis. Routine coagulation studies revealed mild decrease of protein C (0. Read More

BMJ Case Rep 2018 Nov 28;11(1). Epub 2018 Nov 28.

Infectious diseases, Hospital for Tropical Diseases, London, UK.

A young previously healthy patient presented with sepsis and cavitating pneumonia. was isolated from blood cultures and subsequent CT neck showed an internal jugular vein thrombosis. Treatment was with antibiotics, anticoagulation and supportive management. Read More

Health Inf Manag 2018 Dec 18:1833358318819105. Epub 2018 Dec 18.

2 Lancaster University, UK.

Background:: Intracranial venous thrombosis (ICVT) accounts for around 0.5% of all stroke cases. There have been no previously published studies of the International Classification of Diseases, Tenth Edition (ICD-10) validation for the identification of ICVT admissions in adults. Read More

Int J Cardiol 2019 Mar 6;278:225-231. Epub 2018 Dec 6.

Department of Cardiology, Cardiology I, University Medical Center Mainz, Johannes Gutenberg-University Mainz, Mainz, Germany.

Background: Atherosclerosis is associated with increased cardiovascular mortality. Associations between venous thromboembolism and atherosclerosis were recently reported. We aimed to investigate the impact of symptomatic atherosclerosis on adverse outcomes in patients with pulmonary embolism (PE) and to identify significant differences among patients with PE stratified by symptomatic atherosclerosis. Read More

J Clin Pharm Ther 2019 Feb 28;44(1):122-124. Epub 2018 Nov 28.

Touro College of Pharmacy, New York, New York.

What Is Known And Objective: Lemierre's syndrome is often misdiagnosed as a common cold or viral infection. Fusobacterium necrophorum is the most common causative organism. The recommended treatment regimen is 6 weeks of a beta-lactam antibiotic along with metronidazole. Read More

Am J Case Rep 2018 Nov 26;19:1405-1409. Epub 2018 Nov 26.

Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA.

BACKGROUND Severe pneumonia requiring admission to an intensive care unit carries high morbidity and mortality. Evidence-based management includes early administration of empiric antibiotics against plausible bacterial pathogens while awaiting results of microbiologic cultures. However, in over 60% of pneumonia cases, no causative pathogen is identified with conventional diagnostic techniques. Read More

Emerg Med Clin North Am 2019 Feb;37(1):95-107

Department of Emergency Medicine, Loma Linda University School of Medicine, 11234 Anderson Street MC A-108, Loma Linda, CA 92354, USA. Electronic address:

Infection of the neck is a relatively common emergency department complaint. If not diagnosed and managed promptly, it may quickly progress to a life-threatening infection. These infections can result in true airway emergencies that may require fiberoptic or surgical airways. Read More

JAMA 2018 12;320(22):2367-2368

Amsterdam Cardiovascular Sciences, University of Amsterdam, Amsterdam, the Netherlands.

Clinical Question: Which treatments for lower extremity superficial thrombophlebitis (ST) are associated with lower rates of venous thromboembolic events (VTEs) vs placebo?

Bottom Line: A dose of 2.5 mg of fondaparinux administered subcutaneously once daily for 45 days is associated with fewer cases of symptomatic VTE without an increase in major bleeding vs placebo. Low-molecular-weight heparin (LMWH) and nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with lower rates of ST extension or recurrence vs placebo, but data regarding symptomatic VTE remain inconclusive. Read More

Ann R Coll Surg Engl 2019 Feb 29;101(2):e52-e54. Epub 2018 Oct 29.

Maxillofacial Surgery Operative Unit, Department of Life, Health and Environmental Sciences, 'San Salvatore' City Hospital , L'Aquila , Italy.

Lemierre's syndrome is also known as the forgotten disease, and is a rare but life-threatening complication that can arise after surgical extractions of infected mandibular third molars. Owing to its rarity, oral and maxillofacial surgeons might not immediately recognise or can underestimate the pathological signs, and consequently do not apply the appropriate therapy to treat the syndrome. Here, we report on the occurrence and management of a case of Lemierre's syndrome, where the complications affected the right sigmoid sinus. Read More

BMJ Case Rep 2018 Oct 27;2018. Epub 2018 Oct 27.

Division of Pulmonary Medicine, Thoracic Center, St. Luke's International Hospital, Tokyo, Japan.

BMC Infect Dis 2018 Oct 19;18(1):523. Epub 2018 Oct 19.

Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh Hospital, 4-23-15 Kotobashi, Sumida-ku, Tokyo, 130-8575, Japan.

Background: Gemella bergeri is one of the nine species of the genus Gemella and is relatively difficult to identify. We herein describe the first case of septic shock due to a Gemella bergeri coinfection with Eikenella corrodens.

Case Presentation: A 44-year-old Asian man with a medical history of IgG4-related ophthalmic disease who was prescribed corticosteroids (prednisolone) presented to our hospital with dyspnea. Read More

Angiol Sosud Khir 2018;24(3):77-84

Saratov State Medical University named after V.I. Razumovsky under the Ministry of Public Health of the Russian Federation, Saratov, Russia.

The authors examined the effect of the presence of undifferentiated connective tissue dysplasia (UCTD) on the clinical course of lower-limb varicose veins (LLVV) and acute varicothrombophlebitis (AVTP) in patients after the Troyanov-Trendelenburg operation. We carried out a prospective comparative study of the remote results during three years after the Troyanov-Trendelenburg operation in a total of 132 patients suffering from AVTP. The Study Group included 67 patients found to have more than four phenotypic traits of UCTD, thus suggesting the presence of UCTD. Read More

Vascular 2019 Feb 7;27(1):27-32. Epub 2018 Sep 7.

Charm Vein Center, Seoul, Republic of Korea.

Objectives: To investigate the initial outcomes of 1940 nm diode laser in the treatment of incompetent saphenous veins.

Methods: This was a prospective observational study. We treated 89 patients with 160 incompetent saphenous veins using a 1940 nm diode laser and bare fiber. Read More

Int J Pediatr Otorhinolaryngol 2018 Oct 16;113:298-301. Epub 2018 Aug 16.

Department of Otolaryngology Head and Neck Surgery, "Haemek" Medical Center, Afula, Israel. Electronic address:

Septic thrombophlebitis of the facial vein (STFN) commonly presents with facial erythema, tenderness, and swelling above the involved vessel. Due to its rarity, diagnosis and treatment remain a challenge. Lemierre syndrome (LS), which consists of a triad of internal jugular vein thrombophlebitis, septicemia, and distant septic emboli, is a more common entity of which physicians are more familiar. Read More

Medicine (Baltimore) 2018 Aug;97(35):e11903

Department of Stomatology, the First People's Hospital of Changzhou, the Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China.

Rationale: Senile patients with LS complicated with DNM are rarely seen in clinical practice, and extensive cervical incision and drainage plus administration of effective antibiotics are the basis for treatment. Currently, the treatment controversy mainly has focused on whether mediastinal incision and drainage is necessary for patients with type I DNM, and whether anticoagulation therapy is required for jugular venous emboli and distant metastatic emboli induced by LS.

Patient Concerns: A female, 76 years old, developed pain of tonsil on right side 5 days ago, and felt that the pain aggravated complicated with dysphagia and swelling pain of neck on both sides since then. Read More

J Oral Maxillofac Surg 2018 Dec 30;76(12):2649.e1-2649.e9. Epub 2018 Jul 30.

Member of Kerman Dental and Oral Diseases Research Center; Associate Professor, Department of Oral Medicine, Dental School, Kerman University of Medical Science, Kerman, Iran. Electronic address:

Deep vein thrombosis (DVT) is caused primarily by obstruction of blood flow in the deep veins in the lower limbs. It is a form of thrombophlebitis and can be a major cause of morbidity and mortality in hospitalized patients. This report describes an unusual case of DVT in a 21-year-old woman with Class III malocclusion who underwent bimaxillary orthognathic surgery (bilateral sagittal split osteotomy and Le Fort I osteotomy) under general anesthesia. Read More

Cureus 2018 Jun 5;10(6):e2742. Epub 2018 Jun 5.

Department of Hematology and Oncology, Staten Island University Hospital, Staten Island, USA.

Serious thrombotic complications associated with an acute cytomegalovirus (CMV) infection in immunocompromised and immunocompetent patients are becoming increasingly recognized. While typically asymptomatic and self-limiting, an acute CMV infection appears to demonstrate a rare propensity for a vascular thrombosis, such as deep vein thrombosis (DVT), thrombophlebitis, and pulmonary embolism (PE). It remains unclear whether other predisposing factors play a role in its pathogenesis. Read More

Rofo 2018 Dec 6;190(12):1166-1168. Epub 2018 Aug 6.

Institute for Clinical Radiology and Nuclear Medicine, University-Medical-Center Mannheim, University-Medical-Center Mannheim, Germany.

Zhonghua Kou Qiang Yi Xue Za Zhi 2018 Aug;53(8):552-554

Department of Thoracic Surgery, The First People's Hospital of Changzhou, The Third Affiliated Hospital of Soochow University, Changzhou Jiangsu 213000, China.

Lemierre syndrome is a rare, potentially fatal condition characterized by internal jugular vein thrombosis following an acute oropharyngeal infection, often accompanied with cervical necrotizing fasciitis. This paper reviews 5 cases of Lemierre syndrome with cervical necrotizing fasciitis, extensive cervical drainage and sufficient antibiotics is crucial treatment for Lemierre syndrome, anticoagulation combined with antibiotics is safe and effective for propagation or nonresolution of the thrombus. Read More

J Microbiol Immunol Infect 2018 Jun 27. Epub 2018 Jun 27.

Department of Emergency Medicine, Inha University School of Medicine, Incheon, South Korea. Electronic address:

Pylephlebitis is a condition with thrombophlebitis of the portal mesenteric venous system. Herein, we report a patient suggesting odontogenic bacteremia as a risk factor of pylephlebitis. He was diagnosed as superior mesenteric vein thrombophlebitis, and blood cultures grew Gemella sanguinis and Streptococcus gordonii. Read More

BMJ Case Rep 2018 Jul 19;2018. Epub 2018 Jul 19.

Department of Internal Medicine, Michigan State University, Sparrow Hospital, East Lansing, Michigan, USA.

An 18-year-old woman presented to clinic with acute pharyngitis with 4/4 Centor criteria. Rapid streptococcal antigen test was negative. The patient, who was allergic to penicillin, was prescribed azithromycin. Read More

Eur J Radiol 2018 Aug 21;105:49-55. Epub 2018 May 21.

Division of Pediatrics, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Street, Unit 0087, Houston, TX, 77030, United States. Electronic address:

Purpose: To evaluate the frequency of tumor thrombus in the large veins draining primary pelvic osteosarcoma on early cross-sectional imaging studies and its effect on patient survival.

Materials And Methods: Our retrospective study included all patients with primary pelvic osteosarcoma treated at our facility between January 2000 and May 2014, who were ≤ 45 years of age, and had adequate imaging studies and clinical follow up. Four radiologists evaluated for tumor in the large draining veins on initial CT, MRI and PET/CTs. Read More

Medicine (Baltimore) 2018 Jun;97(26):e11228

Department of Infection Control and Prevention, Kurume University School of Medicine.

Rationale: The ancient infectious diseases, Lemierre's Syndrome and Bezold's Abscesses are rare.

Patient Concerns: A 70-year-old Japanese woman with a 15-year history of Parkinson's disease was referred to our hospital due to fever, occipital headache and bilateral shoulder pain that had continued for three months. She had been prescribed prednisolone due to a diagnosis of polymyalgia rheumatica. Read More

J Postgrad Med 2018 Jul-Sep;64(3):164-169

Department of Pediatrics, Seth G.S. Medical College and KEM Hospital, Mumbai, Maharashtra, India.

Deep vein thrombosis and pulmonary thromboembolism are rare and life threatening emergencies in children. We report an 11-year old female who presented with acute complaints of high grade fever, pain in the left thigh and inability to walk and breathlessness since 6 days. On physical examination, there was a diffuse tender swelling of the left thigh, tachypnea, tachycardia with hyperdynamic precordium and bilateral basal crepitations. Read More

BMJ Case Rep 2018 Jun 23;2018. Epub 2018 Jun 23.

Department of Infectious Diseases and Tropical Medicine, Birmingham Heartlands Hospital, Heart of England NHS Hospital Trust, Birmingham, UK.

A 26-year-old woman presented with a 5-day history of fever after returning from Bali. She denied sexual contact abroad. On examination, there was suprapubic tenderness and a widespread maculopapular rash. Read More

Infection 2018 Oct 20;46(5):721-724. Epub 2018 Jun 20.

Department of Public Health and Infectious Diseases, "Sapienza" University of Rome, Rome, Italy.

Introduction: The emergence of carbapenemase-producing Klebsiella pneumonia (KPC-Kp) has become a significant problem in terms of public health and clinical outcome in many hospitals in Southern Europe. Treatment options are usually limited and effective treatment of infections caused by these pathogens is a considerable challenge for clinicians. Ceftazidime-avibactam has been recently approved for the treatment of difficult-to-treat infections due to aerobic Gram-negative organisms in patients with limited treatment options. Read More

Vasc Endovascular Surg 2018 Nov 18;52(8):633-635. Epub 2018 Jun 18.

1 Division of Vascular Surgery, Department of Surgery, Stanford Health Care, Stanford, CA, USA.

Background:: We report the case of a 90-year old woman who presented with septic pulmonary emboli due to suppurative thrombophlebitis at an old peripheral intravenous site.

Methods:: After unsuccessful treatment with antibiotics, the patient was taken to the operating room for excision and drainage of the purulent superficial vein.

Results:: We review the literature and discuss the presentation, risk factors, treatment options, and complications of this often-overlooked disease entity. Read More

BMJ Case Rep 2018 Jun 13;2018. Epub 2018 Jun 13.

Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.

Vasc Endovascular Surg 2018 Nov 14;52(8):641-647. Epub 2018 Jun 14.

1 Division of Vascular Surgery, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

We describe the cases of 2 patients who had septic thrombophlebitis and were successfully managed with endovascular thrombectomy. Patient A developed septic thrombophlebitis of the inferior vena cava after several retroperitoneal resections for metastatic renal cell carcinoma. The thrombus was successfully removed via endovascular mechanical balloon thrombectomy. Read More

Arq Neuropsiquiatr 2018 May;76(5):358

Universidade de Campinas, Departamento de Neurologia, Campinas SP, Brasil.

Cutis 2018 May;101(5):322;325;326

Department of Pathology, University of Illinois at Chicago, USA.

QJM 2018 Oct;111(10):729-730

Department of Cardiothoracic Surgery, Royal Infirmary of Edinburgh, Edinburgh, UK.

Tidsskr Nor Laegeforen 2018 05 18;138(9). Epub 2018 May 18.

Mycopathologia 2019 Feb 22;184(1):177-180. Epub 2018 May 22.

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Histoplasma capsulatum is one of the most common pathogenic dimorphic fungi in Thailand. Its usual clinical syndrome is progressive disseminated histoplasmosis, whereas isolated hepatic histoplasmosis is extremely rare. Here, we report the world's first reported case of hepatic histoplasmosis with pylephlebitis in a 45-year-old Thai male who underwent orthotopic liver transplantation due to hepatitis B cirrhosis. Read More

Intern Med 2018 Sep 18;57(18):2607-2612. Epub 2018 May 18.

Department of Diagnostic and Generalist Medicine, Dokkyo Medical University Hospital, Japan.

Mondor's disease (MD) is a rare disease that manifests with a palpable cord-like induration on the body surface. In general, MD is a self-limited, benign thrombophlebitis that resolves in four to eight weeks without any specific treatment. Cases of MD can be roughly categorized into three different groups based on the site of the lesion as follows: original MD of the anterolateral thoracoabdominal wall, penile MD with dorsum and dorsolateral aspects of the penis, and axillary web syndrome with mid-upper arm after axillary surgery. Read More

J Pediatr 2018 09 26;200:289. Epub 2018 Apr 26.

Division of Clinical Immunology and Allergy Children's Hospital Los Angeles Department of Pediatrics Keck School of Medicine University of Southern California Los Angeles, California.

BMJ Case Rep 2018 Apr 28;2018. Epub 2018 Apr 28.

Radiology, NHS Ayrshire and Arran, Crosshouse Hospital, Ayr, UK.

A 16-year-old boy presented to hospital with a 6-day history of diarrhoea, vomiting and abdominal pain. During his admission he was found to be hypotensive, tachycardic and persistently feverish. Blood cultures taken on admission isolated CT scanning of his neck showed a non-occlusive thrombus of the right internal jugular vein and a small right parapharyngeal abscess. Read More

Minerva Med 2018 Aug 24;109(4):276-279. Epub 2018 Apr 24.

Gemelli Policlinic, Rome, Italy -

Background: Superficial thrombophlebitis (STP) is a relatively frequent pathology characterized by possible extension to the deep venous circulation, with notable local inflammatory reaction which is treated by subcutaneous administration of Fondaparinux. Stasis dermo-hypodermitis is characterized by cutaneous hyperpigmentation and eczema, treatment for which consists of the use of drugs targeting endothelial cells (mesoglycan, FFPM, sulodexide). In this study we evaluated the impact of local application of a mixture of semi-synthetic polysulfated galactosaminoglycans on the regression rate of STP and dermo-hypodermitis in patients treated with best medical therapy (BMT). Read More

Histopathology 2018 Sep 8;73(3):407-416. Epub 2018 Jun 8.

Department of Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Aims: Interobserver reliability of histopathological features in differentiation between cutaneous polyarteritis nodosa (cPAN) and superficial thrombophlebitis (ST) by assessment of inter-rater agreement of five histological features was investigated.

Methods And Results: All sections of cPAN and ST were evaluated independently by three experienced pathologists and one resident of pathology. The histopathological features studied included elastic fibre distribution in the vascular wall, a smooth muscle arrangement pattern, an internal elastic lamina pattern, fibrinoid necrosis and luminal thrombosis. Read More

Insights Imaging 2018 Aug 19;9(4):631-642. Epub 2018 Apr 19.

Department of Radiology, "Magna Grecia" University, Viale Europa, 88100, Catanzaro, Italy.

The number and complexity of endovascular procedures performed via either arterial or venous access are steadily increasing. Albeit associated with higher morbidity compared to the radial approach, the traditional common femoral artery remains the preferred access site in a variety of cardiac, aortic, oncologic and peripheral vascular procedures. Both transarterial and venous cannulation (for electrophysiology, intravenous laser ablation and central catheterisation) at the groin may result in potentially severe vascular access site complications (VASC). Read More

BMJ Case Rep 2018 Apr 18;2018. Epub 2018 Apr 18.

Pulmonary/Critical Care Medicine, NewYork-Presbyterian Queens, Flushing, New York, USA.