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Eur J Obstet Gynecol Reprod Biol 2019 Mar 11;237:57-63. Epub 2019 Mar 11.

The French Public Health Agency, Non-Communicable Disease and Trauma Division, Saint-Maurice, France.

Objectives: To determine whether the risk of thromboembolic complications is higher in women following unsuccessful fertility treatment (FT) and in pregnant women following successful FT, and whether the risk differs according to FT type.

Study Design: This is an observational prospective cohort study. All French women aged 18-45 years who received FT between 2013 and 2015 were selected from the French health insurance claim database which registers healthcare consumption for the entire French population. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Department of Surgery, Northwest Community Hospital, Arlington Heights IL.

Introduction: Pregnancy is a hypercoagulable state associated with a fivefold increase in risk of venous thromboembolism. Thrombolysis is the preferred level of care for patients with acute ilio-femoral deep vein thrombosis, however most studies exclude pregnant patients, highlighting the lack of data regarding the efficacy and safety of thrombolytic therapy for the mother and fetus.

Case Report: We describe successful use of thrombolytic therapy in conjunction with ultrasound to remove a large ileo-femoral deep vein thrombosis (DVT) in a first trimester patient with phlegmasia cerulea dolens. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Director of Performance Improvement, Northwest Community Healthcare, Arlington Heights, IL 60005. Electronic address:

Introduction: Almost 80% of patients with end stage renal disease (ESRD) initiate dialysis via a central venous catheter (CVC). CVCs are associated with multiple complications and a high cost of care. The purpose of our project is to determine the impact of early cannulation arteriovenous grafts (ECAVGs) on quality of care and costs. Read More

Ann Vasc Surg 2019 Apr 19. Epub 2019 Apr 19.

Centre for Outpatient Vascular Treatment CAT.

Background: The procedure aims to show our results with a novel non-tumescent, non-thermal technique to treat varicose veins. The V Block occlusion stent is a minimally invasive device for treating reflux of the great saphenous vein. It is an office-based procedure that does not require tumescence anesthesia. Read More

J Thromb Haemost 2019 Apr 22. Epub 2019 Apr 22.

Winship Cancer Institute of Emory University, Atlanta, GA, USA.

We would like to thank Dufrost and colleagues for their valuable comments on our systematic review [1]. The significant risk of venous as well as arterial thrombosis among patients with the antiphospholipid syndrome (APS) is well-established, and we acknowledge the challenges of anticoagulation therapy in this patient population. This article is protected by copyright. Read More

Medicine (Baltimore) 2019 Apr;98(16):e14925

Anesthesiology Department, Jingjiang People's Hospital, Jingjiang, Jiangsu Province, China.

Background: The optimal anesthetic technique remains debated in patients undergoing total-hip arthroplasty (THA). The purpose of this meta-analysis was to test the efficacy of general and spinal anesthesia for patients undergoing THA.

Methods: In January 2018, we searched PubMed, Embase, Web of Science, Cochrane Database of Systematic Reviews, and the Google database. Read More

J Orthop Trauma 2019 May;33(5):216-219

Department of Orthopaedic Surgery, University Hospitals, Cleveland Medical Center, Case Western Reserve University, Cleveland, OH.

Objective: To compare the rates of deep venous thrombosis (DVT), rates of pulmonary embolus (PE), and complication profiles of warfarin and low-molecular-weight heparin (LMWH) in patients undergoing operative fixation of hip fractures.

Design: Retrospective cohort study.

Setting: Insurance-based database of more than 22 million patient records. Read More

Cureus 2019 Feb 6;11(2):e4023. Epub 2019 Feb 6.

Internal Medicine, University of Connecticut, Farmington, USA.

Cerebral sinus venous thrombosis (CSVT) is a rare complication of acute mastoiditis with a declining incidence in the post-antibiotic era. In the adult population its incidence ranges from three to four cases per million. Here we present a case of a 47-year-old female with triple negative breast cancer on chemotherapy who underwent a molar tooth extraction, which was followed two weeks later by the sudden onset of left-sided frontotemporal headache radiating down the face, left ear fullness with associated hearing loss, toothache, and left orbital pain. Read More

Ann Indian Acad Neurol 2019 Apr-Jun;22(2):221-224

Department of Imaging and Interventional Radiology, Kerala Institute of Medical Sciences, Thiruvananthapuram, Kerala, India.

Deep cerebral venous thrombosis (DCVT) remains a very rare entity among the spectrum of cerebral venous thrombosis (CVT). Due to the bilateral draining territories, DCVT nearly invariably causes bilateral infarction with predictably dismal prognosis. However, rare instances of DCVT with unilateral infarction having favorable prognosis have been described, but pose a wide range of differentials to the clinician and require careful interpretation of clinical and radiological features for accurate diagnosis. Read More

Clin Hemorheol Microcirc 2019 Apr 19. Epub 2019 Apr 19.

Hand Surgery and Reconstructive Microsurgery Group of the Institute of Orthopedics and Traumathology-Clinics Hospital of University of Sao Paulo-São Paulo, Brazil.

Background: The optimal number of veins to be anastomosed in perforator flaps for limb reconstruction and its influence on the results remain controversial. Venous thrombosis of microvascular anastomoses is a commonly recorded complication in soft tissue reconstruction.

Objective: To evaluate the effect of two venous anastomoses in the incidence of venous thrombosis for limb reconstruction using anterolateral thigh (ALT) microsurgical free flaps. Read More

J Stroke Cerebrovasc Dis 2019 Apr 18. Epub 2019 Apr 18.

Department of Neurology, Osaka City University Graduate School of Medicine, Osaka City, Japan.

Pulmonary arteriovenous fistula (PAVF), a vessel malformation connecting the pulmonary circulation to the systemic circulation while bypassing the pulmonary capillaries, can cause paradoxical cerebral infarction. It is often associated with hereditary hemorrhagic telangiectasia (HHT), a genetic disease characterized by multiple dermal, mucosal, and visceral telangiectasia causing recurrent bleeding. Paradoxical cerebral embolism caused by PAVF without HHT is rare. Read More

Am J Case Rep 2019 Apr 21;20:562-566. Epub 2019 Apr 21.

Department of Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.

BACKGROUND Pseudomonal infection is the most common cause of malignant otitis externa (MOE), which typically affects elderly diabetic patients. Fungi are a rare cause of MOE. MOE can be life-threatening if not recognized and treated promptly. Read More

Surg Obes Relat Dis 2019 Mar 20. Epub 2019 Mar 20.

Department of Surgery, Division of General Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin. Electronic address:

Background: There is no consensus regarding the optimal venous thromboembolism (VTE) prevention strategy following bariatric surgery. Post-discharge chemoprophylaxis is frequently recommended for high-risk patients with little supporting data.

Objectives: To define practices related to post-discharge chemoprophylaxis in the United States. Read More

Br J Anaesth 2019 Apr 17. Epub 2019 Apr 17.

University of Linköping, Linköping, Sweden; Department of Cardiothoracic Anaesthesia and Intensive Care Medicine, Linköping University Hospital, Linköping, Sweden.

Background: Centrally inserted totally implanted vascular access ports (PORTs) and peripherally inserted central catheters (PICCs) are widely used for the administration of chemotherapy. Our aim was to study the incidence of catheter-related deep venous thrombosis in patients with cancer receiving chemotherapy through either a PICC or a PORT.

Methods: Adults with non-haematological cancer (mainly breast and colorectal) from two Swedish oncology centres were included and followed for up to 1 yr. Read More

Thromb Haemost 2019 Apr 20. Epub 2019 Apr 20.

Thrombosis and Atherosclerosis Research Institute, McMaster University, Hamilton, Ontario, Canada.

Background:  Deep vein thrombosis (DVT) can lead to pulmonary embolism (PE), but the mechanisms responsible for this progression are unknown. Previously, we showed that inhibition of thrombin-mediated activation of factor (F) XIII promotes venous thrombus stability in a murine model.

Aim:  In this study, we investigate the consequence of attenuating fibrinolysis, using FXIII, α-antiplasmin (α-AP) or ε-aminocaproic acid (EACA) supplementation, on clot lysis and venous thrombus stability using the same mouse model. Read More

Clin Chim Acta 2019 Apr 16;495:205-209. Epub 2019 Apr 16.

Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China. Electronic address:

Background: Increasing evidence suggests the role of non-criteria aPLs as important supplements to the current criteria aPLs in APS. In this study, we evaluated the clinical performance of a panel of non-criteria antibodies to phospholipid antigens, including, phosphatidylserine (aPS), phosphatidylinositol (aPI), sphingomyelin (aSM), phosphatidylcholine (aPC) and phosphatidylethanolamine (aPE) in a well-defined Chinese APS cohort.

Methods: A total of 229 subjects were tested, including 86 patients with APS, 104 disease controls (DCs) and 39 healthy controls (HCs). Read More

J Vasc Access 2019 Apr 19:1129729819838795. Epub 2019 Apr 19.

1 Department of Nephrology, Hospital Ruber Juan Bravo, Madrid, Spain.

Introduction: Graft is an alternative to native arteriovenous fistula to ensure permanent vascular access in hemodialysis patients. The most common complication is significant stenosis, which frequently causes thrombosis and graft loss. Periodic monitoring and surveillance with elective correction of stenotic lesions can prolong graft survival. Read More

Microsurgery 2019 Apr 19. Epub 2019 Apr 19.

Department of Hand, Plastic, and Reconstructive Surgery, Microsurgery, Burn Center, BG Trauma Center, Department of Plastic and Hand Surgery, University of Heidelberg, Ludwigshafen, Germany.

Background: The aim of this study was to evaluate outcome and safety of free flaps to the upper extremity by pooled, summarized rates, compared with the existing pooled results of the lower extremity from literature, and to improve the level of evidence in a meta-analysis.

Methods: A literature search of PubMed and Embase was conducted addressing publications between January 2000 and April 2018. Publications were selected by inclusion/exclusion criteria on safety and outcome. Read More

Front Cardiovasc Med 2019 2;6:33. Epub 2019 Apr 2.

Laboratory for Clinical Thrombosis and Hemostasis, Maastricht, Netherlands.

Inflammation and hypercoagulability play a pivotal role in venous thromboembolism and atherothrombosis. Since venous thrombosis increases the risk of atherothrombotic events and vice versa, common mechanisms may be involved. To elucidate the role of neutrophils and coagulation in the occurrence of atherothrombotic events in patients with a history of deep vein thrombosis (DVT or peripheral artery disease (PAD). Read More

Cureus 2019 Feb 4;11(2):e4005. Epub 2019 Feb 4.

Internal Medicine, Bridgeport Hospital, Milford, USA.

Venous thrombosis is a vascular disorder which is a consequence of Virchow's triad: hypercoagulability, venous stasis, and endothelial injury. While lower extremity deep venous thrombosis is common, upper torso thrombosis is a rare clinical condition and usually a complication of central venous catheterization or malignancy-related paraneoplastic syndromes. Herein, we present a rare case of a 64-year-old male who presented with right upper extremity and right facial swelling who was found to have a thrombus in the right internal jugular vein and right subclavian vein with no predisposing factors. Read More

Case Rep Obstet Gynecol 2019 14;2019:5702983. Epub 2019 Mar 14.

Department of General Internal Medicine, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.

Extra-hepatic portal vein thrombosis (EHPVO) represents the obstruction of the portal vein outside the liver and is not related to chronic liver disease or neoplasia. In chronic EHPVO, collateral veins and portal hypertension develop, resulting in splenomegaly and variceal formation. Myeloproliferative neoplasms (MPN) are the most frequent acquired etiology of EHPVO. Read More

J Neurosci Rural Pract 2019 Apr-Jun;10(2):278-282

Department of Medicine, Division of Neurology, 7-112L Clinical Sciences Building, University of Alberta, Edmonton, Canada.

Objective: Our study aims to evaluate the etiologic and clinical features of cerebral venous sinus thrombosis (CVST) in Saudi Arabia, and secondarily whether gender plays a role in CVST.

Materials And Methods: Data were collected retrospectively from the stroke registry during the period from January 2008 to April 2018, and the patients with the diagnosis of CVST were identified, and data were analyzed for any gender-specific differences in clinical presentation and etiology of cerebral venous thrombosis.

Results: There were 15 females while 11 males with a female:male ratio of 1. Read More

J Vasc Surg Venous Lymphat Disord 2019 May;7(3):364-374

Department of Surgery, Rijnstate, Arnhem, The Netherlands. Electronic address:

Objective: Endothermal techniques have proved to be effective for treatment of incompetent truncal veins. The tumescentless mechanochemical ablation (MOCA) technique has become an alternative treatment modality, but its outcome with regard to endothermal techniques is still unclear.

Methods: A multicenter prospective randomized controlled trial was designed comparing MOCA with radiofrequency ablation (RFA) to treat great saphenous vein incompetence with the hypothesis that MOCA is associated with less postprocedural pain and a comparable anatomic and clinical success rate at 1-year follow-up. Read More

Syst Rev 2019 Apr 18;8(1):99. Epub 2019 Apr 18.

Department of Medicine, University of Ottawa and The Ottawa Hospital Research Institute, 1053 Carling Avenue, Ottawa, ON, K1Y 4E9, Canada.

Background And Purpose: Cerebral venous thrombosis causes disability from venous infarct and hemorrhage and potential mortality. Anticoagulation improves survival and disability outcomes, yet direct oral anticoagulants are currently not indicated in cerebral venous thrombosis due to lack of evidence, despite being on the market for nearly a decade. This systematic review will collate evidence of reported safety and efficacy of direct oral anticoagulant therapy in cerebral venous thrombosis. Read More

BMC Cancer 2019 Apr 18;19(1):364. Epub 2019 Apr 18.

Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China.

Background: Our aim of the study is to investigate the feasibility of preoperative prediction for hepatocellular carcinoma (HCC) histological grading using gadoxetic acid-enhanced magnetic resonance imaging (MRI).

Methods: This study included one hundred and fifty-six patients with solitary HCC. Preoperative gadoxetic acid-enhanced MRI findings were retrospectively analyzed. Read More

PLoS Genet 2019 Apr 18;15(4):e1008110. Epub 2019 Apr 18.

Laboratory of Theoretical and Applied Functional Genomics, Novosibirsk State University, Novosibirsk, Russia.

Varicose veins of lower extremities (VVs) are a common multifactorial vascular disease. Genetic factors underlying VVs development remain largely unknown. Here we report the first large-scale study of VVs performed on a freely available genetic data of 408,455 European-ancestry individuals. Read More

Respirol Case Rep 2019 Jul 8;7(5):e00424. Epub 2019 Apr 8.

Department of Internal Medicine, Division of Pulmonary and Critical Care University of Michigan Ann Arbor Michigan USA.

Phelgmasia cerulea dolens (PCD) is a rare cause of shock that can complicate deep venous thrombosis and carries a high risk of mortality. We present a case of extensive bilateral lower extremity deep vein thrombosis associated with an inferior vena cava filter which rapidly progressed to PCD and refractory shock. Read More

J Surg Case Rep 2019 Apr 10;2019(4):rjz024. Epub 2019 Apr 10.

Temple Heart and Vascular Institute, Temple University Hospital, 3509 N. Broad Street, Boyer Pavilion 4th Floor, Philadelphia, PA 19140, USA.

May-Thurner syndrome (MTS) is an anatomic variant where the overlying right common iliac artery compresses and chronically obstructs the left common iliac vein, leading to thrombosis. Interventions for symptomatic MTS include endovascular thrombectomy and stenting. Occluding venous thrombus can be fatal to transplanted allografts. Read More

Acta Haematol 2019 Apr 17:1-7. Epub 2019 Apr 17.

Institute of Medical Biochemistry and Laboratory Diagnostics, Thrombotic Center, General University Hospital, and First Faculty of Medicine, Charles University, Prague, Czech Republic.

Background/aims: Endothelial progenitor cells (EPCs) and circulating endothelial cells (CECs) have been described as markers of endothelial damage and dysfunction in several diseases, including deep venous thrombosis. Their role in patients with known thrombophilia has not yet been evaluated. Both EPCs and CECs represent extremely rare cell populations. Read More

FP Essent 2019 Apr;479:21-29

Womack Army Medical Center Department of the Army, WAMC Stop A 2817 Reilly Rd, Ft Bragg, NC 28310-7301.

Risk factors for deep venous thrombosis (DVT) include immobility, recent or current hospitalization, recent surgery, recent infection, and cancer. Patients with suspected venous thromboembolism should be evaluated with the Wells score or modified Wells score (which adds a previous DVT) to determine the likelihood of DVT. A low or moderate probability score and a normal D-dimer test result exclude DVT. Read More

Angiol Sosud Khir 2019 ;25(1):153-157

Federal Centre of Cardiovascular Surgery under the RF Ministry of Public Health, Penza, Russia.

The authors carried out a retrospective study aimed at revealing predictors of early incompetence of coronary bypass grafts in patients with the ejection fraction below 30%. The study included a total of 104 patients presenting with coronary artery disease and the ejection fraction below 30%, who over the period from 2009 to 2016 underwent coronary artery bypass grafting with the use of autovenous and autoarterial conduits. 77 patients endured plasty of an aneurysm of the left ventricle (LV), 89 patients sustained plasty of the valvular apparatus. Read More

Angiol Sosud Khir 2019 ;25(1):82-86

Department of Surgery, Institute of Additional Professional Education, South Ural State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia.

Stenting of the iliac veins in patients with post-thrombotic syndrome is an intervention associated with a low risk of complications, high primary and secondary patency rates, low incidence of restenosis, leading to a significant decrease in the severity of symptoms of chronic venous disease and a high rate of trophic ulcer healing, as compared with conservative therapy. Unlike subcutaneous veins, the formation of calcinates in deep veins after endured thrombosis is of considerably less frequent occurrence. Described in the article is a clinical case report concerning successful stenting of the iliofemoral venous segment in a female patient presenting with post-thrombotic syndrome, a trophic ulcer of the crus, and the presence of linear calcinosis in the lumen of the iliac veins and common femoral vein. Read More

Angiol Sosud Khir 2019 ;25(1):19-23

Department of Surgery, Institute of Additional Professional Education, South Ural State Medical University of the RF Ministry of Public Health, Chelyabinsk, Russia.

Cancer-associated thromboembolic complications in malignant neoplasms are commonly encountered. They deteriorate the course of the underlying disease and are frequent causes of death. The oncological patient is at high risk of not only thrombosis but haemorrhage during anticoagulant therapy. Read More

Int Angiol 2019 Apr 15. Epub 2019 Apr 15.

Faculty of Medicine, University of Belgrade, Belgrade, Serbia.

Background: Pediatric peripheral vascular trauma carries significant risk of complications including limb loss and long-term invalidity. Mechanisms and types of morphological lesions are very diverse. The objectives of this study are to present a single vascular centre experience in surgical approach to pediatric vascular injuries and to analyze the main challenges related to this clinical entity. Read More

Am J Health Syst Pharm 2019 Apr 17. Epub 2019 Apr 17.

Houston Methodist Hospital, Houston, TX.

Purpose: The risks of venous thromboembolism (VTE) and bleeding with direct oral anticoagulants (DOACs) and aspirin for thromboprophylaxis after orthopedic surgery were studied.

Methods: A single center, retrospective study was conducted to examine patients who underwent a major orthopedic surgery from 2011 to 2015. The primary endpoint evaluated was the net clinical outcome of bleeding and thrombosis rates between the DOAC and aspirin groups. Read More

Vasa 2019 Apr 17:1-10. Epub 2019 Apr 17.

1 Vivantes Klinikum im Friedrichshain, Berlin, Germany.

Thromboses of cerebral veins and/or sinuses (CVT) encompass a clinically rather heterogenous, relatively rare entity, which is nonetheless an important cause of stroke in the young. While until the mid of the last century the prognosis of CVT was thought to be poor or even fatal in the majority of cases, the advance and wider use of modern imaging technology since the early 1980s, together with the results of registries and population-based studies, revealed that CVT is more frequent and less life-threatening than previously assumed. However, because headache is frequently the only symptom, many oligosymptomatic cases might be overlooked. Read More

J Cardiovasc Imaging 2019 Apr;27(2):154-155

Division of Cardiology, Department of Internal Medicine, Chonbuk National University Medical School, Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.

Ann Intensive Care 2019 Apr 16;9(1):47. Epub 2019 Apr 16.

Department of Intensive Care, Erasme Hospital, Université Libre de Bruxelles (ULB), Route de Lennik, 808, 1070, Brussels, Belgium.

The 2018 Paris Intensive Care symposium entitled "Update in Neurocritical Care" was organized in Paris, June 21-22, 2018, under the auspices of the French Intensive Care Society. This 2-day post-graduate educational symposium comprised several chapters, aiming first to provide all-board intensivists with current standards for the clinical assessment of altered consciousness states (including coma and delirium) and peripheral nervous system in critically ill patients, monitoring of brain function (specifically, electro-encephalography) and best practices for sedation-analgesia-delirium management. An update on the treatment of specific severe brain pathologies-including ischaemic/haemorrhagic stroke, cerebral venous thrombosis, hypoxic-ischaemic brain injury, immune-mediated and infectious encephalitis and refractory status epilepticus-was also provided. Read More

Vasc Specialist Int 2019 Mar;35(1):28-33

Endovascular and Vascular Division, Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Korea.

Purpose: Deep vein thrombosis (DVT) is the third most common cause of cardiovascular morbidity and mortality. Anticoagulation has been the primary treatment modality for acute DVT. However, catheter-directed thrombolysis (CDT) has recently become widely accepted as an additional therapy to anticoagulation. Read More

Int J Gynecol Cancer 2019 Apr 16. Epub 2019 Apr 16.

Department of Gynaecological Oncology, St. James's Hospital, Dublin, Ireland.

Objective: Gynaecological cancer patients have a high risk of developing venous thromboembolism (VTE). There is limited information on patient experience and compliance with an extended low molecular weight heparin prophylaxis in this setting. The aim of this study was to assess patient compliance, satisfaction and experience with the extended low molecular weight heparin prophylaxis after major surgery for gynaecological cancer. Read More

F1000Res 2019 14;8:182. Epub 2019 Feb 14.

Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh.

A 24-year-old male was presented to us with sudden onset of chest pain and dyspnea for the past one hour. There was no history of calf pain, trauma, surgery, prolonged immobilization, long-haul air travel, bleeding diathesis or any other co-morbidity. The patient denied any addiction history. Read More

Thromb Res 2019 Apr 10;178:85-90. Epub 2019 Apr 10.

Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais State, Brazil; Hematology Unit, University Hospital, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais State, Brazil. Electronic address:

Background: Cerebral venous thrombosis (CVT), although rare, is potentially fatal. Few studies have investigated risk factors associated with recurrent venous thromboembolism (VTE) after a first CVT event of which most are from Caucasian populations. The aim of this study was to evaluate risk factors associated with recurrent VTE after a first CVT event in a South American-population. Read More

Thromb Res 2019 Apr 9;178:75-78. Epub 2019 Apr 9.

Service d'hématologie biologique, Hôpital Lariboisière, AP-HP, Paris, France; INSERM UMR_S1140, Université Paris Descartes, Paris, France. Electronic address:

Thromb Res 2019 Apr 11;178:69-74. Epub 2019 Apr 11.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100730, China.

Objective: To explore the functional exercises of deep breathing and lower limb motions for the prevention of venous thrombosis in patients undergoing major surgery for gynecologic malignancy.

Methods: All eligible patients admitted to the gynecologic oncology unit were randomized into the study and control groups. A comprehensive set of functional exercises was provided to the study group under the instruction and supervision of medical staff. Read More

J Am Acad Dermatol 2019 Apr 13. Epub 2019 Apr 13.

Department of Dermatology, Mayo Clinic, Rochester, MN, USA; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, MN, USA. Electronic address:

Background: Klippel-Trenaunay Syndrome (KTS) is a vascular malformation overgrowth syndrome characterized by capillary malformation, venous malformation and limb overgrowth, +/- lymphatic malformation. Patients are at an increased risk of hemorrhage and venous thromboembolism (VTE). Consequently, women with this condition often are counseled to avoid pregnancy, but there is minimal data available on the relationship between pregnancy, VTE and bleeding risk. Read More

J Clin Invest 2019 Apr 16;130. Epub 2019 Apr 16.

Deep vein thrombosis (DVT), caused by alterations in venous homeostasis is the third most common cause of cardiovascular mortality; however, key molecular determinants in venous thrombosis have not been fully elucidated. Several lines of evidence indicate that DVT occurs at the intersection of dysregulated inflammation and coagulation. The enzyme ectonucleoside tri(di)phosphohydrolase (ENTPD1, also known as CD39) is a vascular ecto-apyrase on the surface of leukocytes and the endothelium that inhibits intravascular inflammation and thrombosis by hydrolysis of phosphodiester bonds from nucleotides released by activated cells. Read More

Hip Int 2019 Apr 16:1120700019841600. Epub 2019 Apr 16.

Department of Orthopaedic Surgery, Stanford Hospital and Clinics, Redwood City, CA, USA.

Introduction: Debate over the ideal agent for venous thromboembolism (VTE) prophylaxis after total hip arthroplasty (THA) has led to changes in prescribing trends of commonly used agents. We investigate variation in utilisation and the differences in VTE incidence and bleeding risk in primary THA after administration of aspirin, warfarin, enoxaparin, or factor Xa inhibitors.

Methods: 8829 patients were age/sex matched from a large database of primary THAs performed between 2007 and 2016. Read More

Minerva Med 2019 Jun;110(3):251-258

University of Milano-Bicocca, Milan, Italy.

Venous thromboembolism (VTE) is a major cause of morbidity and mortality in patients with cancer. For over a decade, the gold standard of treatment and secondary prevention of cancer-associated thrombosis (CAT) has been represented by low-molecular-weight heparins (LMWHs), which are currently recommended as the first-line treatment for CAT. Among the LMWHs that were more extensively tested in patients with CAT, tinzaparin is a LMWH produced by the enzymatic degradation of porcine-derived unfractionated heparin. Read More

ANZ J Surg 2019 Apr 15. Epub 2019 Apr 15.

Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Background: Patients undergoing total hip arthroplasty (THA) or total knee arthroplasty (TKA) are at risk of venous thromboembolism (VTE). Australian orthopaedic guidelines recommend aspirin and low-molecular-weight heparin (e.g. Read More

MMW Fortschr Med 2019 Apr;161(7):52

Kompetenzzentrum für Proktologie, Königstraße 49/Theatergasse 23, D-90402, Nürnberg, Deutschland.