Search Our Scientific Publications & Authors

J Hematol Oncol 2022 May 21;15(1):69. Epub 2022 May 21.

Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

International clinical practice guidelines have progressively endorsed direct oral anticoagulants (DOACs) as an alternative to low-molecular-weight heparins (LMWHs) monotherapy for the initial and long-term treatment of cancer-associated thrombosis (CAT). Several new randomized controlled trials (RCTs) have recently reported additional results on the safety and efficacy of DOACs in this setting. We performed an updated meta-analysis of all publicly available data from RCTs comparing DOACs with LMWHs for the treatment of CAT. Read More

Kidney Int 2022 Jun;101(6):1303

Urology and Nephrology Center, Department of Nephrology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, Zhejiang, China. Electronic address:

Sci Rep 2022 May 20;12(1):8519. Epub 2022 May 20.

Intensive Care Department, Ministry of National Guard Health Affairs, Riyadh, Kingdom of Saudi Arabia.

There are contradictory data regarding the effect of intermittent pneumatic compression (IPC) on the incidence of deep-vein thrombosis (DVT) and heart failure (HF) decompensation in critically ill patients. This study evaluated the effect of adjunctive use of IPC on the rate of incident DVT and ventilation-free days among critically ill patients with HF. In this pre-specified secondary analysis of the PREVENT trial (N = 2003), we compared the effect of adjunctive IPC added to pharmacologic thromboprophylaxis (IPC group), with pharmacologic thromboprophylaxis alone (control group) in critically ill patients with HF. Read More

Thromb Res 2022 May 17;215:19-29. Epub 2022 May 17.

Nottingham Digestive Diseases Centre (NDDC), Translational Medical Sciences, School of Medicine, University of Nottingham, NG7 2UH, UK; NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust and the University of Nottingham, Nottingham, NG7 2UH, UK. Electronic address:

Background And Aims: Historically, bleeding was thought to be a frequent and fatal complication of liver disease. However, thrombosis due to coagulation disorders in cirrhosis remains a real risk. We aim to systematically analyse published articles to evaluate epidemiology of venous thromboembolism (VTE) in chronic liver disease (CLD). Read More

J Exp Orthop 2022 May 20;9(1):47. Epub 2022 May 20.

Department of Orthopedic Surgery, Akita University Graduate School of Medicine, 1-1-1 Hondo, Akita, 010-8543, Japan.

Purpose: Patients undergoing knee surgery are at high risk for deep vein thrombosis (DVT), which is infrequent but potentially life-threatening. It has not been identified how to efficiently detect high-risk DVT while minimizing bleeding complications from anticoagulation. We hypothesized that the degree of activation of thrombotic markers may correlate with the size of the thrombus. Read More

Int J Neurosci 2022 May 20:1-7. Epub 2022 May 20.

Department of Neurology, University of Kansas Medical Center.

First line treatment for cerebral venous thrombosis (CVT) is systemic anticoagulation. In cases with symptoms of elevated ICP, endovascular thrombectomy (EVT) is pursued. We describe two cases in which dual stent-retrievers were used for EVT. Read More

Khirurgiia (Mosk) 2022 (5):75-80

Orel Regional Clinical Hospital, Orel, Russia.

Objective: To study the efficacy and safety of percutaneous mechanical thrombectomy and long-term anticoagulation with rivaroxaban for proximal deep vein thrombosis.

Material And Methods: We analyzed the effectiveness of treatment in 60 patients with proximal deep vein thrombosis divided into 2 homogeneous groups by 30 people. Standard therapy was performed in the first group, therapy with percutaneous mechanical thrombectomy was applied in the second group. Read More

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096221099893

Department of Pharmacy Practice, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Several guidelines endorsed the indefinite use warfarin or heparin-containing products for acute venous thromboembolism (VTE) treatment and secondary prevention and discouraged the use of direct oral anticoagulants (DOAC) for patients diagnosed with antiphospholipid syndrome (APS). However, adequate anticoagulation despite warfarin therapy remains a challenge in APS patients. Using DOACs in APS patients is seen in clinical practice, despite the lack of evidence to support their use in this population. Read More

Cureus 2022 Apr 15;14(4):e24157. Epub 2022 Apr 15.

Onco-hematology, Hospital Piacenza, Piacenza, ITA.

Background Several studies have recommended the use of vascular access in the treatment of COVID-19 patients. However, little is known about the utility and safety of using a peripheral ultrasound-guided vascular access device (UGVAD) at the bedside of hospitalized COVID-19 patients. To examine this, a retrospective monocenter study was carried out at the oncology-hematology department of Azienda Sanitaria di Piacenza, Italy. Read More

Surgeon 2022 May 16. Epub 2022 May 16.

Department of Vascular Surgery, Royal College of Surgeons in Ireland and Beaumont Hospital, Dublin, Ireland.

Objective: A systematic review and meta-analysis was performed to determine the role of thromboprophylaxis in the prevention of venous thromboembolism in patients undergoing varicose vein interventions.

Methods: PUBMED, EMBASE and Web of Science were searched for comparative studies of patients undergoing varicose vein interventions and received either thromboprophylaxis or no thromboprophylaxis. Data were collected on the number of thrombotic events including deep vein thrombosis (DVT), pulmonary embolism (PE) and endothermal heat-induced thrombosis (EHIT) as well as bleeding events. Read More

Ann Vasc Surg 2022 May 16. Epub 2022 May 16.

Loyola University Medical Center, Department of Surgery, Division of Vascular Surgery and Endovascular Therapy, 2160 S. First Avenue, EMS 110 Room 3215, Maywood, IL, USA, 60153. Electronic address:

Objective: The primary objective of this study is to assess the risk of thromboembolic events in hospitalized patients with COVID-19 and study the impact of thromboembolic events on hospital course and mortality risk during the initial height of the SARS-CoV-2 pandemic.

Methods: A retrospective review of all adult inpatients (≥18 years old) with COVID-19 infection at a single academic institution from March 15, 2020 - July 1, 2020 was performed. Collected data included patient demographics, comorbidities, hospital admission type, thromboembolic events, laboratory values, use of anticoagulants/antiplatelet agents, hospital length of stay, and in-hospital mortality. Read More

Am J Med Sci 2022 May 16. Epub 2022 May 16.

Department of Pathology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250033, China. Electronic address:

Background: Deep venous thrombosis (DVT) is a thrombus formed in the deep venous cavity and can cause a fatal pulmonary embolism. Since circulating miRNAs are used as molecular markers for the early warning and diagnosis of various diseases, such as tumors and cardiovascular diseases, the purpose of the present study was initially to identify differential expression circulating miRNAs in plasma, and then explore potential biomarkers for DVT.

Methods: The plasma of 30 patients with DVT before and after DVT related endovascular interventions constituted 6 sample pools for miRNA sequencing, and the levels of 22 plasma miRNAs were significantly changed. Read More

J Thromb Haemost 2022 May 19. Epub 2022 May 19.

Division of Internal Medicine, Department of Medicine, McGill University, Montreal, QC, Canada.

Background: Patients with cancer-associated thrombosis (CAT) are treated with full-dose anticoagulation for at least three months, but optimal dosing thereafter is unknown.

Aim: We explored the feasibility of extended prophylactic-dose low-molecular-weight heparin (LMWH) treatment following a minimum of three months of full-dose LMWH.

Methods: We conducted a multicenter prospective pilot study of patients with CAT who completed at least three months of therapeutic-dose LMWH. Read More

Support Care Cancer 2022 May 19. Epub 2022 May 19.

Warwick Medical School, University of Warwick, Coventry, England, UK.

Cancer-associated thrombosis (CAT) adversely affects the quality of life and survival of people with cancer. A holistic approach is optimal for the treatment and secondary prophylaxis of venous thromboembolism (VTE) including shared decision-making around anticoagulation, considering individual risk factors for VTE recurrence, morbidities from VTE, and resources available in cancer centres around the world. Taking a global perspective on availability and cost, this paper guides the reader through the wider aspects of treatment and secondary thromboprophylaxis which, in turn, influence the recent international guidelines. Read More

Vascular 2022 May 19:17085381221102783. Epub 2022 May 19.

Anatomy Department, 9311Sapienza University of Rome, Rome, Italy.

Chronic venous disorders (CVD) of the lower limbs can be treated with different strategies. Typically, conservative management is based on compression therapy, anticoagulants and venoactive drugs. Endovenous treatments remain the gold standard to treat saphenous insufficiency, with sclerotherapy and surgery maintaining a role in selected cases. Read More

Biomed Res Int 2022 9;2022:6560816. Epub 2022 May 9.

Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China.

Objective: A retrospective case-control study was performed to observe the effect and clinical significance of early electroacupuncture combined with enhanced recovery after surgery (ERAS) on pain perception and dysfunction after total knee arthroplasty (TKA).

Methods: About 100 patients who diagnosed with TKA from February 2019 to April 2021 were enrolled in our hospital. The patients were arbitrarily assigned into control group and study group. Read More

Front Endocrinol (Lausanne) 2022 2;13:876028. Epub 2022 May 2.

Department of Cardiology, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany.

Background: An increasing level of evidence suggests that obesity not only is a major risk factor for cardiovascular diseases (CVDs) but also has adverse outcomes during COVID-19 infection.

Methods: We used the German nationwide inpatient sample to analyze all hospitalized patients with confirmed COVID-19 diagnosis in Germany from January to December 2020 and stratified them for diagnosed obesity. Obesity was defined as body mass index ≥30 kg/m according to the WHO. Read More

Cureus 2022 Apr 15;14(4):e24162. Epub 2022 Apr 15.

Internal Medicine, University of Hawaii, Honolulu, USA.

Introduction: Cirrhosis is a significant cause of mortality and morbidity worldwide. Recent studies suggested that cirrhosis is associated with an increased risk of venous thromboembolism (VTE), which disproves the old belief that chronic liver disease coagulopathy is considered protective against VTE. We conducted a retrospective study which is to our knowledge the first of its kind to assess clinical characteristics and outcomes of decompensated cirrhosis (DC) patients admitted with acute pulmonary embolism (APE). Read More

Front Immunol 2022 2;13:870981. Epub 2022 May 2.

Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

The iliac vein can be severely stenosed and occluded due to thrombosis, tumor compression, or an anatomical abnormality. Such occlusion could result in limb swelling, venous claudication, and persistent leg ulcers. Its devastating sequelae heavily impact patients lifestyles and the social economy. Read More

Shock 2022 May;57(5):714-721

Department of Vascular Surgery, Beijing Shijitan Hospital, Capital Medical University, Haidian District, Beijing, China.

Objective: Endothelial progenitor cells-released extracellular vesicles (EPCs-EVs) have previously been reported to promote the dissolution of deep venous thrombosis (DVT) through delivery of microRNA (miR). Given that, this research was projected to search the relative action of EPCs-EVs transferring of miR-136-5p in DVT.

Methods: From EPCs transfected with miR-136-5p agomir or antagomir, EVs were extracted and then injected into DVT mice. Read More

Int Angiol 2022 May 18. Epub 2022 May 18.

Department of Angiology and Vascular Surgery, Centro Hospitalar Universitário de S. João, Porto, Portugal.

Introduction: Venous Thromboembolism (VTE) is a possible complication after varicose vein surgery, reported after both open and endovascular interventions. Nonetheless, there are no internationally accepted recommendations regarding postoperative VTE prevention strategies, with some authors advocating for its use, while others recommend against it. This study aims to systematically review current evidence on the efficacy and safety of chemothromboprophylactic strategies after varicose vein surgery. Read More

Ther Umsch 2022 Jun;79(5):254-259

Klinik für Rheumatologie, Universitätsspital Zürich.

Chronic Periaortitis The term chronic periaortitis encompasses several fibroinflammatory diseases that manifest on or around the abdominal aorta which may be associated with aneurysm formation. Formerly distinct entities are grouped together, such as idiopathic retroperitoneal fibrosis (Ormond's disease), inflammatory aortic aneurysm, and perianeurysmal retroperitoneal fibrosis. They may also occur IgG4-related. Read More

Cardiol Young 2022 May 18:1-5. Epub 2022 May 18.

Department of Cardiology and Grown-up Congenital Heart Disease, ICLAS, Rapallo, GE, Italy.

Background And Objectives: Infradiaphragmatic partial anomalous pulmonary venous connection is occasionally diagnosed in adulthood. Management of infradiaphragmatic PAPVC depends on anatomy and clinical presentation.

Methods: Over a 10-year period, we observed seven adult patients (median age 29 years) with partial anomalous pulmonary venous connection. Read More

Pol J Radiol 2022 1;87:e202-e206. Epub 2022 Apr 1.

JSS Medical College, Jssaher, India.

Purpose: To ascertain the role of optic nerve sheath diameter (ONSD) in the evaluation of cerebral venous sinus thrombosis (CVST).

Material And Methods: A retrospective study with convenient sampling was done during the period November 2018 to January 2020. Forty-one patients across all age groups with magnetic resonance venography (MRV) diagnosis of CVST and 82 gender-matched controls were included in the study. Read More

Cureus 2022 Apr 14;14(4):e24145. Epub 2022 Apr 14.

Hematology/Oncology, Stony Brook University Hospital, Port Jefferson, USA.

Inferior vena cava thrombosis (IVCT) is a potentially fatal condition that may rarely occur in young patients with COVID-19 infection. This report describes a young adult female with a recent COVID 19 infection who presented with fever, bilateral flank pain, elevated inflammatory markers, and evidence of thrombosis in the inferior vena cava (IVC) on computed tomography (CT). The patient required treatment with anticoagulation therapy and catheter-directed thrombolysis, IVC filter placement, and mechanical suction-assist thrombectomy. Read More

Cancer Drug Resist 2022 7;5(1):214-228. Epub 2022 Mar 7.

Irish Centre for Vascular Biology, School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin D02YNVV, Ireland.

Multiple Myeloma (MM) is a common haematological malignancy that is associated with a high rate of venous thromboembolism (VTE) with almost 10% of patients suffering thrombosis during their disease course. Recent studies have shown that, despite current thromboprophylaxis strategies, VTE rates in MM remain disappointingly high. The pathophysiology behind this consistently high rate of VTE is likely multifactorial. Read More

Contrast Media Mol Imaging 2022 28;2022:7795801. Epub 2022 Apr 28.

Department of Nuclear Medicine, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou 310014, Zhejiang, China.

Objective: To compare the clinical efficacy of total knee arthroplasty (TKA) and unicondylar knee arthroplasty (UKA) in the treatment of knee osteoarthritis (KOA).

Methods: A retrospective analysis was conducted on 30 patients admitted to the Department of Orthopaedics of Yijishan Hospital from 2020 to 2021. The patients were divided into UKA group ( = 15) and TKA group (control,  = 15). Read More

Res Pract Thromb Haemost 2022 Mar 10;6(3):e12701. Epub 2022 May 10.

Department of Medicine/Hematology University of Miami Hospital/Sylvester Comprehensive Cancer Center Miami Florida USA.

Background: Chemotherapy-induced thrombocytopenia (CIT) is common during treatment with antineoplastic therapies and may adversely impact chemotherapy dose intensity. There is no approved therapy for CIT. In our recent phase II randomized study, romiplostim led to correction of platelet counts in 85% of treated patients and allowed resumption of chemotherapy, with low rates of recurrent CIT in the first two cycles or 8 weeks of chemotherapy. Read More

J Belg Soc Radiol 2022 27;106(1):24. Epub 2022 Apr 27.

Presbyterian Medical Center, KR.

Radiologists need to be familiar with that ovarian vein thrombosis can occur as a complication of urinary tract infection. Ovarian vein thrombosis is a rare disease in which a majority of cases occur during the postpartum period. There are few case reports for ovarian vein thrombosis associated with urinary tract infection in non-postpartum women. Read More