Search Our Scientific Publications & Authors

Thromb Haemost 2019 Jan 16. Epub 2019 Jan 16.

McMaster University and the Thrombosis and Atherosclerosis Research Institute, Hamilton, Ontario, Canada.

The double-blind, randomized, AMPLIFY trial compared 6 months' treatment with apixaban (10 mg twice daily for 7 days and 5 mg twice daily thereafter) versus conventional treatment (subcutaneous enoxaparin [1 mg/kg twice daily for ≥ 5 days] overlapped and followed by warfarin [international normalized ratio = 2.0-3.0]) in patients with acute venous thromboembolism (VTE). Read More

Turk Neurosurg 2018 Oct 17. Epub 2018 Oct 17.

Heinrich-Braun-Clinic.

Aim: In glioblastoma multiforme, the balance between the procoagulant system, anticoagulant system and fibrinolytic system is impaired in favour of hypercoagulability. The aim of this study was to compare glioblastoma multiforme with astrocytoma grade II by subjectively evaluating the levels of prothrombin and biotinylation thrombin, and G protein serum protease activatin receptors, as tissue factors causing hypercoagulation and affecting coagulation.

Material And Methods: Specimens from 35 cases with glioblastoma multiforme and 23 cases with astrocytoma grade II were evaluated immunohistochemically. Read More

JAMA Cardiol 2019 Jan 16. Epub 2019 Jan 16.

London School of Hygiene and Tropical Medicine, London, United Kingdom.

Importance: It is uncertain to what extent established cardiovascular risk factors are associated with venous thromboembolism (VTE).

Objective: To estimate the associations of major cardiovascular risk factors with VTE, ie, deep vein thrombosis and pulmonary embolism.

Design, Setting, And Participants: This study included individual participant data mostly from essentially population-based cohort studies from the Emerging Risk Factors Collaboration (ERFC; 731 728 participants; 75 cohorts; years of baseline surveys, February 1960 to June 2008; latest date of follow-up, December 2015) and the UK Biobank (421 537 participants; years of baseline surveys, March 2006 to September 2010; latest date of follow-up, February 2016). Read More

Ortop Traumatol Rehabil 2018 Oct;20(5):401-408

Klinika Traumatologii i Ortopedii, Wojskowy Instytut Medyczny, Warszawa, Polska / Department of Traumatology and Orthopaedics, Military Institute of Medicine, Warsaw, Poland.

Background: Total hip replacement activates the coagulation and fibrinolysis systems. The aim of this paper is to describe the concentrations of these proteins following elective total hip replacement.

Material And Methods: This prospective laboratory study enrolled 30 patients (including 18 women) who had been qualified for primary total hip replacement due to idiopathic osteoarthritis. Read More

Reumatologia 2018 23;56(6):406-408. Epub 2018 Dec 23.

Department of Rheumatology, Trakya University School of Medicine, Edirne, Turkey.

Antiphospholipid syndrome is a cause of arterial and venous thrombosis especially in the young adult population. Although dural sinus thrombosis is a relatively rare complication of antiphospholipid syndrome, it may be a cause of morbidity and mortality. Extension of thrombosis and involvement of deep venous structures are poor prognostic factors in patients with dural sinus thrombosis, but the rate of near-complete recanalization is not known in antiphospholipid syndrome-related dural sinus thrombosis. Read More

Chin Med Sci J 2018 Nov;33(4):267-271

Department of Radiology, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China.

Cerebral venous sinus thrombosis (CVST) is a rare condition in early pregnancy. A 22-year-old Chinese woman at 10 weeks of pregnancy requested induced abortion and was diagnosed as CVST for a severe headache accompanying with nausea and vomiting. The patient was treated successfully with anticoagulation, followed by amniocentesis, and finally succeeded in induction of labor safely. Read More

Lung Cancer Manag 2017 Dec 1;6(3):87-91. Epub 2017 Dec 1.

Department of Pulmonology, Respiratory Oncology Unit, University Hospitals Leuven, UZ Leuven, Herestraat 49, 3000 Leuven, Belgium.

Thromboembolic events (TEEs) are frequent in cancer patients, especially venous thrombosis. Arterial thrombosis is less frequent. Chemotherapy increases the risk of these TEEs. Read More

J Vasc Bras 2018 Jul-Sep;17(3):257-261

Hospital Aristides Maltez, Liga Bahiana Contra o Câncer, Unidade de Terapia Intensiva, Salvador, BA, Brasil.

Central venous catheter implantation for hemodialysis is commonly performed in large centers and its complications are sometimes associated with insufficient training of those who perform it, but may also be related to the patient's clinical condition. The present study reports two cases of complications related to use of a short-stay catheter for hemodialysis. In the first case, the cannula was inadvertently inserted into the left subclavian artery, causing arterial thrombosis, which was conservatively managed and good collateral perfusion was documented with vascular echography. Read More

J Vasc Bras 2018 Jul-Sep;17(3):215-219

Universidade do Estado do Rio de Janeiro (UERJ), Hospital Universitário Pedro Ernesto, Rio de Janeiro, RJ, Brasil.

Civil aviation has seen a steady increase in the number of scheduled flights over the last ten years and, as a result, more passengers are traveling by air. This has been associated with an increase in flight-related diseases, especially on long-haul flights. One of the most feared complications during flights is venous thromboembolism (VTE), but its true incidence is difficult to measure because of a lack of consensus on elements such as the definition of how long after landing a VTE can be considered to be related to a flight and even how long a flight must last to be considered of long duration. Read More

J Vasc Bras 2018 Jul-Sep;17(3):208-214

Faculdade de Medicina do ABC, Disciplina de Angiologia e Cirurgia Vascular, Santo André, SP, Brasil.

Background: Adequate flow through a newly created arteriovenous fistula depends on multiple characteristics of the vessels and patient comorbidities. Several studies have related preoperative findings to failure, but few have analyzed the influence of intraoperative findings.

Objectives: To evaluate the predictive value of intraoperative findings on the immediate outcome of radial-cephalic arteriovenous wrist fistulas (RCAVF) by collecting data that are easily measured intraoperatively. Read More

J Vasc Bras 2018 Jul-Sep;17(3):184-192

Universidade Estadual de Campinas - UNICAMP, Faculdade de Odontologia de Piracicaba - FOP, Piracicaba, SP, Brasil.

Background: Venous thromboembolism (VTE) is a cause for growing concern in hospitals, has great impact on morbidity and mortality in clinical and surgical patients, and is the leading cause of preventable hospital deaths. Although there are risk assessment models for hospital inpatients, prophylaxis is still underused or is administered incorrectly.

Objectives: To assess the risk profile for VTE in recently hospitalized clinical and surgical patients and evaluate the thromboprophylactic measures implemented in the first 24 hours of hospitalization. Read More

Zhong Nan Da Xue Xue Bao Yi Xue Ban 2018 Nov;43(11):1246-1250

Department of Geriatrics Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.

Objective: To determine the etiologies and risk factors of intracerebral hemorrhage in young people.
 Methods: A total of 401 young patients with intracerebral hemorrhage were enrolled, and they were assigned into a 20-29 , a 30-39, and a 40-45 age group. The differences of various etiologies and risk factors among the three groups were analyzed. Read More

Hong Kong Med J 2019 Jan 11. Epub 2019 Jan 11.

Department of Surgery, Queen Mary Hospital, Pokfulam, Hong Kong.

Background: Conventional treatment of deep vein thrombosis (DVT) of the lower extremities by anticoagulation alone has been proven to be insufficient to prevent recurrence and post-thrombotic syndrome (PTS). Early restoration of venous patency and preservation of valvular function by endovascular surgery has been advocated. The aim of this study was to review the efficacy and safety of percutaneous mechanical thrombectomy (PMT) against catheter-directed thrombolysis (CDT) in the treatment of acute iliofemoral DVT. Read More

Clin Ther 2019 Jan 11. Epub 2019 Jan 11.

Renown Institute for Heart and Vascular Health, Reno, NV, USA.

Purpose: Renown Health (Reno, Nevada), a large, locally owned, not-for-profit integrated health care network, has developed an institution-wide policy to shift the treatment of deep vein thrombosis (DVT) from a short-acting anticoagulant and vitamin K antagonist to the direct oral anticoagulant rivaroxaban combined with pharmacy-directed follow-up at an outpatient anticoagulation clinic. We examined data on hospitalizations and costs pre-/post-policy change.

Methods: Data were obtained from the electronic health records of adults with newly diagnosed DVT treated at Renown Health. Read More

Am J Kidney Dis 2019 Jan 12. Epub 2019 Jan 12.

Division of Nephrology, Department of Medicine, London Health Sciences Centre, London; Division of Nephrology, Department of Medicine, University of Toronto, Toronto, Canada. Electronic address:

Rationale & Objective: Clinical practice guidelines discourage the use of central venous catheters (CVCs) for vascular access in dialysis. However, some patients have inadequate vessels for arteriovenous fistula creation or choose to use a dialysis catheter. The risks associated with CVC use and their relationship to patient age are poorly characterized. Read More

Mult Scler Relat Disord 2019 01 17;27:424-430. Epub 2018 Oct 17.

Nuffield Department of Clinical Neurosciences, Oxford University Hospitals, Oxford, UK.

J Neurosurg Spine 2019 Jan 11:1-6. Epub 2019 Jan 11.

2Department of Neurosurgery, Duke University Medical Center, Durham, North Carolina.

OBJECTIVEIn the United States, healthcare expenditures have been soaring at a concerning rate. There has been an excessive use of postoperative radiographs after spine surgery and this has been a target for hospitals to reduce unnecessary costs. However, there are only limited data identifying the rate of instrumentation changes on radiographs after complex spine surgery involving ≥ 5-level fusions. Read More

Zhongguo Zhong Xi Yi Jie He Za Zhi 2016 08;36(8):942-945

Objective To observe the prevention of acupoint massage for the occurrence of deep venous thrombosis (DVT) of various risk degrees after gynecologic laparoscopic surgery. Methods Using Autar deep vein risk assessment scale, patients undergoing gynecological laparoscopic surgery from June 2014 to December 2014 were assessed one day before surgery and 24 h after surgery. Patients at moderate and high risks were recruited as subjects in this research by blocking method, 72 in the moderate risk group and 34 in the high risk group. Read More

Clin Microbiol Infect 2019 Jan 10. Epub 2019 Jan 10.

Département de Bactériologie-Virologie, Hygiène et Parasitologie-Mycologie, Centre Hospitalier Régional Universitaire (CHRU) de Brest, 29238 Brest, France; UMR1078 "Génétique, Génomique Fonctionnelle et Biotechnologies", INSERM, Université de Brest, EFS, IBSAM, 29200 Brest, France.

We report a picture of incurvated Gram-negative bacilli corresponding to a Helicobacter cinaedi strain. The strain was isolated from the bloodstream in a woman with atypical Raynaud's disease and a recent history of superficial venous thrombosis. H. Read More

J Vasc Surg Venous Lymphat Disord 2019 Jan 10. Epub 2019 Jan 10.

Division of Interventional Radiology, Mayo Clinic, Rochester, Minn.

Objective: The use of catheter-directed thrombolysis (CDT) may provide clinical benefit in patients with acute deep venous thrombosis (DVT), but significant doubt remains about its indications and risks. We assessed technical success in resolution of acute iliofemoral or central DVT after single-session treatment with a novel mechanical aspiration thrombectomy device as an alternative to initiation of CDT.

Methods: This was a single-center retrospective review of patients with acute iliofemoral or central DVT treated with the Indigo continuous aspiration mechanical thrombectomy 8 system (Penumbra, Inc, Alameda, Calif) from 2016 to 2017. Read More

Biochem Biophys Res Commun 2019 Jan 11. Epub 2019 Jan 11.

Department of Chemistry and Biochemistry, San Diego State University, San Diego, CA, USA. Electronic address:

The endothelial receptor tyrosine kinase Tie2 plays an important role in vascular formation and maintenance. Mutations in Tie2 lead to vascular malformations, which are painful vascular lesions that cause disfigurement, bleeding, and thrombosis. R849W Tie2 is the most common mutation implicated in an inherited form of vascular malformations and has been shown to be activating, though little is known about the kinetic features of catalysis. Read More

J Emerg Med 2019 Jan 8. Epub 2019 Jan 8.

Temple University Hospital, Philadelphia, Pennsylvania.

Background: Internal jugular venous thrombosis (IJVT) is an uncommon condition rarely diagnosed in the outpatient setting. IJVT carries significant morbidity and mortality and must be considered in the differential diagnosis for new-onset neck pain and swelling, especially in the emergency setting. Paget-Schroetter syndrome (PSS), or primary thrombosis secondary to effort, is an uncommon, likely under-recognized etiology of thrombosis. Read More

Dis Mon 2019 Jan 8. Epub 2019 Jan 8.

The University of Chicago Pritzker School of Medicine, Chicago, IL, USA. Electronic address:

Venous thromboembolism (VTE) including pulmonary embolism (PE) and deep vein thrombosis (DVT) is one of the leading causes of preventable cardiovascular disease in the United States (US) and is the number one preventable causes of death following a surgical procedure. Post operative VTE is associated with multiple short and long term complications. We will focus on reviewing the many faces of VTE in detail as they represent common challenging scenarios in clinical practice. Read More

Acta Radiol 2019 Jan 12:284185118823346. Epub 2019 Jan 12.

4 Department of Radiology, The Affiliated Hospital of Qingdao University, Qingdao, PR China.

Background: Acute intracranial hypertension (IH) is commonly found in patients with cerebral venous thrombosis (CVT). Some magnetic resonance imaging (MRI) findings that are suggestive of acute IH and are thus important for planning treatment and improving clinical outcomes have been reported; however, the significance of changes in ventricular size in the presence of acute CVT-related IH remains unclear.

Purpose: To investigate changes in ventricular size in patients with CVT-related IH by MRI and to determine whether such changes are predictors of IH in these patients. Read More

J Thromb Thrombolysis 2019 Jan 12. Epub 2019 Jan 12.

Department of Biomedical Science, College of Life Science, CHA University, 335 Pangyo-ro, Bundang-gu, Seongnam, South Korea.

Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. Read More

Ann Vasc Dis 2018 Dec;11(4):531-534

Research Institute, Shizuoka Cancer Center, Shizuoka, Japan.

: To determine the effect of switching from the initial direct oral anticoagulant (DOAC) to another DOAC on exacerbation of deep vein thrombosis (DVT). : We retrospectively reviewed the data of patients with advanced cancer who experienced exacerbated DVT during initial treatment with DOAC due to new venous thromboembolism (VTE). After switching to another DOAC for VTE recurrence, changes in the thrombus and bleeding were evaluated for 3 months. Read More

Ann Vasc Dis 2018 Dec;11(4):503-510

Department of Cardiovascular Surgery, Japan Red Cross Kumamoto Hospital, Kumamoto, Japan.

Kumamoto was hit by a series of strong earthquakes beginning on April 14, 2016. We treated many deep vein thrombosis (DVT) patients and pulmonary thrombosis (PTE) patients. We came up with a strategy for diagnosis and therapy of venous thromboembolism (VTE). Read More

Radiologe 2019 Jan 11. Epub 2019 Jan 11.

Klinische Abteilung für Kardiovaskuläre und Interventionelle Radiologie, Universitätsklinik für Radiologie und Nuklearmedizin, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

Clinical Issue: Vascular abnormalities are a rare cause of an acute abdomen. They include arterial bleeding and ischemia, the latter being either in the arterial or venous system. The most common cause of an acute ischemic abdomen is acute mesenteric ischemia caused by a thromboembolic occlusion of the superior mesenteric artery, followed by thrombotic occlusion of the portal vein, the mesenteric vein as well as the hepatic veins and the suprahepatic part of the inferior vena cava. Read More

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Department of Cardiovascular Medicine, Tokushima University Graduate School of BiomedicalSciences, Tokushima, Japan.

Antiphospholipid syndrome (APS) is a systemic autoimmune disease characterised by thromboembolic events including venous thromboembolism (VTE) in association with the presence of antiphospholipid antibodies. The standard treatment of VTE historically consists of anticoagulation therapy with warfarin, a vitamin K antagonist. Recently, direct oral anticoagulants, including rivaroxaban have become available for the treatment of VTE. Read More

BMJ Case Rep 2019 Jan 10;12(1). Epub 2019 Jan 10.

Department of Neuroscience, Imaging and Clinical Sciences, "G. d'Annunzio" University, Chieti, Italy.

J Stroke Cerebrovasc Dis 2019 Jan 8. Epub 2019 Jan 8.

Columbia University, Vagelos College of Physicians & Surgeons, New York, New York.

Cerebral venous sinus thrombosis (CVST) requires anticoagulation to promote vessel recanalization. Current anticoagulation paradigms utilize plasma tests from peripheral venous/arterial samples for therapeutic monitoring. We describe a medically-refractory case of CVST in a 35-year-old woman later found to have JAK2 mutation and essential thrombocytosis. Read More

Gynecol Oncol 2019 Jan 8. Epub 2019 Jan 8.

Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States of America; Dana-Farber Cancer Institute, Boston, MA, United States of America.

Objectives: To determine whether perioperative red blood cell transfusion (PRBCT) affects infection, thrombosis, or survival rates in epithelial ovarian cancer (EOC) patients undergoing neoadjuvant chemotherapy (NACT) and interval debulking surgery (IDS).

Methods: Demographics, operative characteristics, and outcome data were abstracted from records of stage IIIC-IV EOC patients managed with NACT-IDS from 01/2010-07/2015. Associations of PRBCT with morbidity and oncologic outcomes were evaluated. Read More

Cancers (Basel) 2019 Jan 10;11(1). Epub 2019 Jan 10.

Autoimmune and Vascular Disease Unit, Internal Medicine (UF04), Center of reference for rare systemic autoimmne diseases (FAI2R), Saint-Louis Hospital, Assistance Publique Hôpitaux de Paris, F-75010 Paris, France.

Venous thromboembolism (VTE) is a common cause of morbidity and mortality in cancer patients and leads to a significant increase in health care costs. Cancer patients often suffer from multiple co-morbidities and have both a greater risk of VTE recurrence and bleeding compared to non-cancer patients. Anticoagulation is therefore challenging. Read More

Semin Thromb Hemost 2019 Jan 11. Epub 2019 Jan 11.

Laboratory for Thrombosis Research, KU Leuven Campus Kulak Kortrijk, Kortrijk, Belgium.

Thrombotic complications are still a major health risk worldwide. Our view on the pathophysiology of thrombosis has significantly changed since the discovery of neutrophil extracellular traps (NETs) and their prothrombotic characteristics. Generated by neutrophils that release their decondensed chromatin as a network of extracellular fibers, NETs promote thrombus formation by serving as a scaffold that activates platelets and coagulation. Read More

Thromb Res 2019 Jan 3;174:148-150. Epub 2019 Jan 3.

University of Insubria, Varese, Italy.

J Trauma Acute Care Surg 2019 Jan 10. Epub 2019 Jan 10.

Department of Surgery, Denver Health Medical Center, University of Colorado.

Background: Viscoelastic tests (VETs), specifically thromboelastography (TEG) and rotational thromboelastometry (ROTEM), are gaining popularity in the management of critically ill surgical patients with hemorrhage or thrombosis due to their comprehensive characterization of the coagulation process and point-of-care availability in comparison to conventional coagulation tests (CCTs). We review current evidence for VET use in patients in the surgical intensive care unit (SICU).

Methods: We searched PUBMED, EMBASE and the Cochrane Library through May 30, 2018 for articles that evaluated the use of VETs in patient populations and clinical scenarios germane to the surgical intensivist. Read More

Blood Coagul Fibrinolysis 2019 Jan 9. Epub 2019 Jan 9.

Laboratorio de Hematología, Sanatorio Allende.

: Hypodysfibrinogenemia and protein C deficiency are coagulopathies and in this report, we describe a young patient with both defects confirmed by molecular genetic tests. The patient was a 24-year-old woman referred for recurrent thrombophlebitis and finally deep venous thrombosis. Routine coagulation studies revealed mild decrease of protein C (0. Read More

Postgrad Med 2019 Jan 11. Epub 2019 Jan 11.

a Department of Internal Medicine , National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University , Tainan , Taiwan.

Multifocal gastrointestinal varices are uncommon and often associated with liver cirrhosis. They consist of varices at the gastroesophageal region and the other sites (i.e. Read More

J Int Med Res 2019 Jan 11:300060518820744. Epub 2019 Jan 11.

4 National Clinical Research Center for Geriatric Disease, Department of Geriatric Cardiology, Chinese PLA General Hospital, Beijing, China.

Objective: This study was performed to determine the risk factors associated with peripherally inserted central catheter (PICC)-related venous thrombosis in patients of advanced age (>65 years).

Methods: In total, 549 hospitalized patients aged 66 to 104 years who were undergoing PICC placement from January 2008 to December 2014 were enrolled. Symptomatic venous thrombosis was confirmed by B-mode or Doppler ultrasonography in the presence of clinical signs. Read More

Ann Transplant 2019 Jan 11;24:25-29. Epub 2019 Jan 11.

Department of Nephrology, Kidney Transplantation and Arterial Hypertension, Children's Memorial Health Institute, Warsaw, Poland.

BACKGROUND Diffuse thrombosis of iliac veins and IVC has been considered a significant technical obstacle in pediatric kidney transplantation (KT). MATERIAL AND METHODS Between 1984 and 2018, 951 KTs were performed in our institution. In 4 children qualified for KT, diffuse thrombosis of iliac veins or IVC was found. Read More

Acta Med Indones 2018 Oct;50(4):343-345

Department of Internal Medicine, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia.

A 38-year-old woman presented with general weakness and vaginal bleeding. One month prior, she had been diagnosed with Evans syndrome (haemolytic anemia with positive Coombs test and thrombocytopenia) and was given oral steroid as maintenance therapy. Her serology examination was negative for hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Read More

Haematologica 2019 Jan 10. Epub 2019 Jan 10.

Dept. of Emergency Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA;

Pak J Pharm Sci 2018 Nov;31(6(Special)):2835-2839

Department of Cardiovascular Surgery, Third Hospital of Xingtai (Xingtai Cardiovascular Hospital), No.108, Steel North Road, Qiaoxi District, Xingtai, Hebei, PR China.

Present study is conducted to investigate the efficacy and safety of application of low-molecular-weight heparin calcium in the prophylaxis of deep venous thrombosis (DVT) following the laparoscopic surgery for gynecological tumors, so as to provide reference for the selection of anti-coagulant procedure in clinical practice. A total of 180 patients who underwent the laparoscopic surgery for the gynecological tumors in this hospital between January 2015 and December 2017 were enrolled in this study, and according to the anti-coagulant procedure, they were divided into two groups, i.e. Read More

Pak J Pharm Sci 2018 Nov;31(6(Special)):2799-2803

Department of Urology, No.3 Hospital of Peking University, Beijing, PR China.

Deep venous thrombosis is a very common complication of orthopedic patients on bed rest. In the present study, comparison of the correlation between serum vascular endothelial growth factor (VEGF) with D-Dimer, fibrinogen and thrombo elastogram was done. 68 elderly fractured patients that had undergone surgery were divided into two groups according to whether they were diagnosed with deep venous thrombosis in the perioperative period or not. Read More

Br J Radiol 2019 Jan 10:20180695. Epub 2019 Jan 10.

3 Department of Radiology, Tekden Hospital , Denizli , Turkey.

Objective:: We aimed to determine the diagnostic performance of the contrast-enhanced and unenhanced combined pulmonary arterial MRI and magnetic resonance venography techniques in the diagnosis of venous thromboembolism (VTE).

Methods:: 44 patients who underwent CT pulmonary angiography (CTPA) for suspected PE constituted the study population. Patients underwent combined pulmonary and lower extremity MRI, and Doppler ultrasonography within 72 h after CTPA. Read More

Cardiovasc Intervent Radiol 2019 Jan 9. Epub 2019 Jan 9.

Interventional Radiology, Galway University Hospital, Galway, Ireland.

Purpose: The purpose of this paper is to assess the applicability of direct computed tomography venography (DCTV) in assessing dominant inflow vein in the femoral confluence in extensive chronic iliofemoral venous obstruction, using venography as the gold standard.

Methods: All DCTVs performed in symptomatic patients with previous iliofemoral deep vein thrombosis subsequently submitted to venography in the period from January 2014 to August 2018 were retrospectively reviewed. Two groups were defined depending on whether the femoral vein (FV) or the deep femoral vein (DFV) was the dominant inflow on venography in order to identify predictors of DFV as dominant inflow in DCTV. Read More

Case Rep Neurol 2018 Sep-Dec;10(3):328-331. Epub 2018 Nov 23.

Department of Neurology, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA.

Stroke in young women is commonly cryptogenic or associated with an underlying hypercoagulable state (e.g., hormonal contraception). Read More

Kardiologiia 2018 Dec 25;58(12):60-65. Epub 2018 Dec 25.

Pirogov Russian National Research Medical University (RNRMU).

Purpose: to elucidate predictors of development of chronic thromboembolic pulmonary hypertension (CTEPH) after acute pulmonary artery thromboembolism (PTE).

Material And Methods: We included in this study 210 patients hospitalized with diagnosis of submassive and massive PTE from 2013 to 2017. In 1 to 3 years after initial hospitalization these patients were invited for control examination. Read More

Clin Orthop Relat Res 2019 Jan 4. Epub 2019 Jan 4.

M. Faour, N. S. Piuzzi, D. P. Brigati, A. K. Klika, M. M. Mont, W. K. Barsoum, C. Higuera-Rueda, Department of Orthopaedic Surgery, Cleveland Clinic Foundation, Cleveland, OH, USA N. S. Piuzzi, Instituto Universitario del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.

Background: Aspirin is established as an effective prophylaxis for venous thromboembolism (VTE) after THA; however, there is no consensus as to whether low- or regular-dose aspirin is more effective at preventing VTE.

Questions/purposes: (1) Is there a difference in the incidence of symptomatic VTE within 90 days of elective THA using low-dose aspirin compared with regular-dose aspirin? (2) Is there a difference in the risk of significant bleeding (gastrointestinal and wound bleeding) and mortality between low- and standard-dose aspirin within 90 days after surgery?

Methods: We retrospectively evaluated 7488 patients in our database who underwent THA between September 2012 and December 2016. A total of 3936 (53%) patients received aspirin alone for VTE prophylaxis after THA. Read More

Clin Orthop Relat Res 2019 Jan 3. Epub 2019 Jan 3.

M. Sloan, G.-C. Lee Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA N. Sheth Department of Orthopaedic Surgery, Pennsylvania Hospital, Philadelphia, PA, USA.

Background: Deep venous thrombosis (DVT) and pulmonary embolus (PE) remain an important cause of morbidity and mortality after THA and TKA. Prior recommendations have advocated for more aggressive prophylaxis for patients with obesity, whereas the evidence supporting these recommendations is conflicting and often based on underpowered studies.

Questions/purposes: (1) What is the association between obesity and DVT and PE after primary and revision THA and TKA? (2) Is there a body mass index (BMI) threshold beyond which DVT and PE risk is elevated?

Methods: We reviewed the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database from 2008 to 2016 to evaluate the reported 30-day rates of DVT, PE, and combined venous thromboembolism (VTE) after primary THA, primary TKA, revision THA, and revision TKA according to BMI as a continuous variable and a categorical variable as defined by the World Health Organization cutoffs for underweight, normal weight, overweight, and obesity. Read More