83,734 results match your criteria Deep Venous Thrombosis


Prevention of Venous Thromboembolism in Hospitalized Medically Ill Patients: A U.S. Perspective.

Thromb Haemost 2020 Jun 3;120(6):924-936. Epub 2020 Jun 3.

University of Oklahoma Health Sciences Center, Hudson College of Public Health, Oklahoma City, Oklahoma, United States.

Venous thromboembolism (VTE) remains a major cause of morbidity and mortality in hospitalized medically ill patients. These patients constitute a heterogeneous population, whose VTE risk is dependent upon the acute medical illness, immobility status, and patient-specific risk factors that have been incorporated into individualized VTE risk assessment models. Randomized placebo-controlled trials (RCTs) have shown both efficacy and net clinical benefit of in-hospital thromboprophylaxis, which is supported by guideline recommendations. Read More

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http://dx.doi.org/10.1055/s-0040-1710326DOI Listing

COVID and Coagulation: Bleeding and Thrombotic Manifestations of SARS-CoV2 Infection.

Blood 2020 Jun 3. Epub 2020 Jun 3.

Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States.

Patients with coronavirus disease 2019 (COVID-19) have elevated D-dimer levels. Early reports describe high venous thromboembolism (VTE) and disseminated intravascular coagulation (DIC) rates, but data are limited. This multicenter, retrospective study described the rate and severity of hemostatic and thrombotic complications of 400 hospital-admitted COVID-19 patients (144 critically ill) primarily receiving standard-dose prophylactic anticoagulation. Read More

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http://dx.doi.org/10.1182/blood.2020006520DOI Listing

From Hemophilia to Deep Venous Thrombosis Patient Samples: How to Perform an Easy Coagulometer Validation Process According to Available Guidelines.

Clin Appl Thromb Hemost 2020 Jan-Dec;26:1076029620915512

Laboratory Hemostasis and Thrombosis, Hematology and Hemotherapy Center, University of Campinas-UNICAMP Campinas, São Paulo, Brazil.

Validation protocols for the evaluation of coagulometers are needed to help professionals select the most suitable system for their regular laboratory routines. The objective of this study was to show how high standard protocols for the coagulometer validation process can fit into the daily laboratory routine. For this study, 45 healthy individuals and 112 patient samples were analyzed. Read More

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http://dx.doi.org/10.1177/1076029620915512DOI Listing

Cardiovascular disease and antiphospholipid syndrome: how to predict and how to treat?

Pol Arch Intern Med 2020 Jun 3. Epub 2020 Jun 3.

The antiphospholipid syndrome (APS) is an autoimmune systemic disease characterized by a hypercoagulable state secondary to the presence of antiphospholipid antibodies (aPL) and associated to vascular thromboses and/or pregnancy complications. Although ≈60% of thrombotic manifestations is represented by venous thrombosis, also cardiovascular (CV) manifestations can occur in APS patients, comprising coronary and/or non-coronary complications. Moreover, several studies consistently showed a more significant atherosclerosis in APS patients than controls. Read More

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http://dx.doi.org/10.20452/pamw.15415DOI Listing

The role of Angiology and Vascular Surgery in the COVID-19 pandemic.

Rev Col Bras Cir 2020 1;47:e20202595. Epub 2020 Jun 1.

Laboratory of Physiology and Microcirculation, University of the State of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.

The New Coronavirus Epidemic (2019-nCoV), discovered in the city of Wuhan, China, in December 2019, presents mainly with pulmonary pneumonia that is preceded by fever, cough and myalgia. However, as the disease spread globally and the number of hospitalizations increased exponentially, it was noted that most serious patients hospitalized by COVID-19 have laboratory changes worthy of attention, such as lymphopenia, neutrophilia, increased time of prothrombin and increased levels of D-dimer. Due to these changes proving to be crucial for the mortality and morbidity rates in this subset of infected people, several studies focusing on the pathophysiology, mainly hematological, of the disease appear every day. Read More

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http://dx.doi.org/10.1590/0100-6991e-20202595DOI Listing

A retrospective observational study investigating the factors associated with right heart failure in patients with primary acute pulmonary embolism and deep vein thrombosis.

J Gen Fam Med 2020 May 4;21(3):63-70. Epub 2020 Mar 4.

Graduate School of Health Science Suzuka University of Medical Science Suzuka Japan.

Background: The relationship between the risk of right heart failure in primary acute pulmonary embolism after embolization and the residual thrombus sites in the pelvis and lower limbs is not clear.

Methods: This single-center retrospective observational study examined the results of contrast-enhanced computed tomography and venous ultrasonography of patients with primary acute PE and DVT. We assessed the association between the occurrence of right heart failure and age; gender; pulmonary thrombosis distribution; most proximal site of deep vein thrombosis in the soleal vein, inferior vena cava (IVC), or common iliac vein (CIV); DVT distribution; and malignancy using univariate and multivariate logistic regression. Read More

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http://dx.doi.org/10.1002/jgf2.305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260167PMC

Validation of the Khorana Score to Assess Venous Thromboembolism and Its Association with Mortality in Cancer Patients: A Retrospective Community-based Observational Experience.

Cureus 2020 Apr 29;12(4):e7883. Epub 2020 Apr 29.

Internal Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, USA.

Introduction: Khorana score (KS) stratifies patients into low, intermediate, and high risk groups for venous thromboembolism (VTE). We examined the generalizability of the KS to risk of VTE and association with mortality.

Methods: A retrospective cohort study was conducted at Mount Auburn Hospital, Cambridge, Massachusetts. Read More

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http://dx.doi.org/10.7759/cureus.7883DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255532PMC

The Issue of the Antiphospholipid Antibody Syndrome.

J Clin Med Res 2020 May 8;12(5):286-292. Epub 2020 May 8.

Hospital das Clinicas, Federal University of Pernambuco, Recife-PE, Brazil.

Antiphospholipid antibody syndrome (APS) is a state of hypercoagulability secondary to an autoimmune disorder. It is associated with thrombotic events in venous and arterial vessels, obstetric complications characterized by recurrent fetal losses, and increased perinatal morbidity. APS is classified as primary, when not associated with other pathologies; or secondary, when associated with an underlying autoimmune disease with, solid tumor, or hematological disorder. Read More

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http://dx.doi.org/10.14740/jocmr4154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7239578PMC

Comparative analysis of enoxaparin versus rivaroxaban in the treatment of cancer associated venous thromboembolism: experience from a tertiary care cancer centre.

Thromb J 2020 24;18. Epub 2020 May 24.

Department of Internal Medicine, Shaukat Khanam Memorial Cancer Hospital & Research Centre, Lahore, Pakistan.

Background: Venous Thromboembolism (VTE) in cancer patients is associated with increased mortality and morbidity. While newer data on use of direct oral anticoagulants (DOACs) in treating cancer associated thrombosis (CAT) is promising; its data is still few and inconsistent across literature. We designed the study to assess if rivaroxaban would be an appealing alternate choice to treat CAT. Read More

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http://dx.doi.org/10.1186/s12959-020-00221-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245926PMC

Features and incidence of thromboembolic disease: A comparative study between high and low altitude dwellers in Saudi Arabia.

Saudi J Biol Sci 2020 Jun 12;27(6):1632-1636. Epub 2020 Mar 12.

Physiology Department, College of Medicine, King Saud University, King Saud University, Medical City, Riyadh, Saudi Arabia.

To estimate and compare the incidence of thromboembolic disease among patients who are clinically suspected for VTE among high and low altitude dwellers in Saudi Arabia. A prospective study conducted over two years (2011-2013) conducted in two different geographical areas in Saudi Arabia; Abha City and Riyadh City. Patients clinically suspected with deep vein thrombosis and pulmonary embolism was recruited to the study. Read More

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http://dx.doi.org/10.1016/j.sjbs.2020.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7253901PMC

Evolution in the risk of adverse events of adjuvant endocrine therapy in postmenopausal women with early-stage breast cancer.

Breast Cancer Res Treat 2020 Jun 1. Epub 2020 Jun 1.

Davidoff Cancer Center, Rabin Medical Center, Beilinson Hospital, 39 Jabotinsky st., 4941492, Petah Tikva, Israel.

Background: Adjuvant endocrine therapy is a gold standard in early-stage, hormone receptor positive breast cancer. In postmenopausal women, aromatase inhibitors (AIs) are associated with improved outcome compared to tamoxifen monotherapy. Differences in the toxicity profiles of these drugs are described; however, little is known about whether the risk of adverse events changes over time. Read More

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http://dx.doi.org/10.1007/s10549-020-05715-1DOI Listing

Real world data regarding the management of cancer-associated thrombosis.

Curr Opin Oncol 2020 Jun 1. Epub 2020 Jun 1.

Department of Radiotherapy-Radiation Oncology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Larisa, Greece.

Purpose Of Review: Patients with cancer are at high risk for thrombotic events, mainly deep vein thrombosis and pulmonary embolism. Low-molecular-weight heparins (LMWHs) and direct oral anticoagulants (DOACs) are among the current treatment options for cancer-associated thrombosis (CAT). We assessed real world data (RWD) regarding treatment patterns of CAT from 1 September 2018 to 31 January 2020. Read More

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http://dx.doi.org/10.1097/CCO.0000000000000646DOI Listing

Chemotherapy associated dural sinus thrombosis presenting as a cerebrospinal fluid leak.

BMJ Case Rep 2020 Jun 1;13(6). Epub 2020 Jun 1.

ENT Department, Imperial College Healthcare NHS Trust, London, UK.

Despite the well documented increased risk of thrombosis in patients with cancer and during chemotherapy, cerebral venous sinus thrombosis (CVT) remains a rare entity. We present a rare case of cerebrospinal fluid (CSF) rhinorrhoea secondary to a left transverse sinus thrombus which occurred 2 years previously during chemotherapy for breast cancer. The patient underwent a three-layer repair using Neuro-Patch, septal cartilage and middle turbinate pedicle flap and was started on acetazolamide. Read More

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http://dx.doi.org/10.1136/bcr-2020-235240DOI Listing

Novel Diagnostic Options without Contrast Media or Radiation: Triggered Angiography Non-Contrast-Enhanced Sequence Magnetic Resonance Imaging in Treating Different Leg Venous Diseases.

Diagnostics (Basel) 2020 May 29;10(6). Epub 2020 May 29.

Division of Thoracic and Cardiovascular Surgery, ChiaYi Chang Gung Memorial Hospital, Chiayi and Chang Gung University, College of Medicine, Taoyuan 61363, Taiwan.

Objectives: Venous diseases in the lower extremities long lacked an objective diagnostic tool prior to the advent of the triggered angiography non-contrast-enhanced (TRANCE) technique.

Methods: An observational study with retrospective data analysis.

Materials: Between April 2017 and June 2019, 66 patients were evaluated for venous diseases through TRANCE-magnetic resonance imaging (MRI) and were grouped according to whether they had occlusive venous (OV) disease, a static venous ulcer (SU), or symptomatic varicose veins (VV). Read More

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http://dx.doi.org/10.3390/diagnostics10060355DOI Listing

Image-proven thromboembolism in patients with severe COVID-19 in a tertiary critical care unit in the United Kingdom.

Thromb Res 2020 May 29;193:1-4. Epub 2020 May 29.

Haemostasis and Thrombosis Centre, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.thromres.2020.05.049DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256551PMC

Thrombosis risk associated with COVID-19 infection. A scoping review.

Thromb Res 2020 May 27;192:152-160. Epub 2020 May 27.

Department of Medicine, Division of Hematology, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. Electronic address:

Background: Infection by the 2019 novel coronavirus (COVID-19) has been reportedly associated with a high risk of thrombotic complications. So far information is scarce and rapidly emerging.

Methods: We conducted a scoping review using a single engine search for studies assessing thrombosis and coagulopathy in COVID-19 patients. Read More

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http://dx.doi.org/10.1016/j.thromres.2020.05.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255332PMC

Spontaneous arterial thrombosis in a patient with advanced ovarian clear cell cancer: a case report and literature review.

J Int Med Res 2020 Jun;48(6):300060520926742

Department of Gynecology & Obstetrics, Zhongshan Hospital, Fudan University, Shanghai, China.

Patients with ovarian cancer are often in a hypercoagulable state and have a high risk of venous thrombosis, including deep vein thrombosis and pulmonary embolism. However, arterial thrombosis is relatively rare in ovarian cancer. We report a case a 46-year-old woman with ovarian clear cell carcinoma who developed arterial and venous thrombosis in the lower extremities as the first manifestation. Read More

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http://dx.doi.org/10.1177/0300060520926742DOI Listing

Recurrent Thrombosis in Patients with Antiphospholipid Antibodies and an Initial Venous or Arterial Thromboembolic Event: A Systematic Review and Meta-Analysis.

J Thromb Haemost 2020 Jun 2. Epub 2020 Jun 2.

RTI International, Research, Triangle Park, NC, USA.

Background: Patients with antiphospholipid antibodies (aPL) and thromboembolism (TE) are at risk for recurrent TE. Few studies, however, distinguish patients based on the initial event.

Objectives: We performed a systematic review and meta-analysis to investigate patients with aPL and venous TE (VTE), provoked or unprovoked, and patients with arterial TE (ATE). Read More

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http://dx.doi.org/10.1111/jth.14936DOI Listing

Etiology of Papilledema in Patients in the Eye Clinic Setting.

JAMA Netw Open 2020 Jun 1;3(6):e206625. Epub 2020 Jun 1.

Department of Ophthalmology, Mayo Clinic College of Medicine, Rochester, Minnesota.

Importance: The study of health conditions associated with papilledema will augment the clinical judgment of eye care professionals treating patients with optic disc edema in determining the urgency of additional evaluation and counseling patients accordingly.

Objectives: To determine the incidence, demographic characteristics, and etiologies of papilledema based on a unique records-linkage research platform; and to describe the demographic and clinical differences between patients with idiopathic intracranial hypertension (IIH) and other causes of papilledema.

Design, Setting, And Participants: Retrospective population-based cross-sectional study of patients treated for papilledema at outpatient eye clinics in Olmsted County, Minnesota, using the Rochester Epidemiology Project. Read More

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http://dx.doi.org/10.1001/jamanetworkopen.2020.6625DOI Listing

Multimodal thromboprophylaxis in low-risk patients undergoing lower limb arthroplasty: A retrospective observational cohort analysis of 1400 patients with ultrasound screening.

J Orthop Surg (Hong Kong) 2020 Jan-Apr;28(2):2309499020926790

Joint Orthopaedic Centre, Sydney, Australia.

Purpose: This study reports the results of a multimodal thromboprophylaxis protocol for lower limb arthroplasty involving risk stratification, intraoperative calf compression, aspirin prophylaxis and early (within 4 h) post-operative mobilisation facilitated by the use of local infiltration analgesia. The study also aimed to identify risk factors for venous thromboembolism (VTE) within a 3-month period following surgery for patients deemed not at elevated risk.

Methods: Patients undergoing knee/hip arthroplasty or hip resurfacing were preoperatively screened for VTE risk factors, and those at standard risk were placed on a thromboprophylaxis protocol consisting of intraoperative intermittent calf compression during surgery, 300 mg/day aspirin for 6 weeks from surgery and early mobilisation. Read More

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http://dx.doi.org/10.1177/2309499020926790DOI Listing

Coronavirus Disease 2019 (COVID-19) Can Masquerade as Acute Postoperative Periprosthetic Joint Infection.

Cureus 2020 Apr 27;12(4):e7857. Epub 2020 Apr 27.

Academic Orthopaedic Department, Papageorgiou General Hospital, Thessaloniki, GRC.

Fever etiology during the first postoperative days following total knee arthroplasty (TKA) may be challenging to solve. Early periprosthetic joint infection is the main reason; however, other equally important causes must be excluded such as thrombosis, deep venous thrombosis, and chest or urinary tract infections. We report the case of a 70-year-old Caucasian female patient presented with high fever reaching 39°C, fatigue, and myalgia lasting for a week after a fully cemented primary TKA. Read More

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http://dx.doi.org/10.7759/cureus.7857DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255085PMC

Neuromuscular blockade management in the critically Ill patient.

J Intensive Care 2020 24;8:37. Epub 2020 May 24.

3Department of Anesthesiology, University of Minnesota Medical School, Minneapolis, MN USA.

Neuromuscular blocking agents (NMBAs) can be an effective modality to address challenges that arise daily in the intensive care unit (ICU). These medications are often used to optimize mechanical ventilation, facilitate endotracheal intubation, stop overt shivering during therapeutic hypothermia following cardiac arrest, and may have a role in the management of life-threatening conditions such as elevated intracranial pressure and status asthmaticus (when deep sedation fails or is not tolerated). However, current NMBA use has decreased during the last decade due to concerns of potential adverse effects such as venous thrombosis, patient awareness during paralysis, development of critical illness myopathy, autonomic interactions, and even residual paralysis following cessation of NMBA use. Read More

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http://dx.doi.org/10.1186/s40560-020-00455-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7245849PMC

Hip Fracture Outcomes During the COVID-19 Pandemic: Early Results from New York.

J Orthop Trauma 2020 May 27. Epub 2020 May 27.

Department of Orthopaedic Surgery, Orthopaedic Trauma Service, Hospital for Special Surgery, New York, NY.

Objective: To evaluate inpatient outcomes among hip fracture patients treated during the COVID-19 pandemic in New York City.

Design: Multicenter retrospective cohort study SETTING:: One Level 1 Trauma Center and one orthopaedic specialty hospital in New York CityPatients/Participants: Fifty-nine consecutive patients (average age 85, range: 65 - 100 years) treated for a hip fracture (OTA/AO 31, 32.1) over a 5-week period, March 20, 2020 to April 24, 2020, during the height of the COVID-19 crisis. Read More

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http://dx.doi.org/10.1097/BOT.0000000000001849DOI Listing

The Michigan Appropriateness Guide for Intravenous Catheters in Pediatrics: miniMAGIC.

Pediatrics 2020 Jun;145(Suppl 3):S269-S284

Patient Safety Enhancement Program and Center for Clinical Management Research, US Department of Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, Michigan.

Objectives: Vascular access device decision-making for pediatric patients remains a complex, highly variable process. To date, evidence-based criteria to inform these choices do not exist. The objective of the Michigan Appropriateness Guide for Intravenous Catheters in pediatrics (miniMAGIC) was to provide guidance on device selection, device characteristics, and insertion technique for clinicians, balancing and contextualizing evidence with current practice through a multidisciplinary panel of experts. Read More

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http://dx.doi.org/10.1542/peds.2019-3474IDOI Listing

A snapshot of cancer-associated thromboembolic disease in 2018-2019: First data from the TESEO prospective registry.

Eur J Intern Med 2020 May 29. Epub 2020 May 29.

Medical Oncology Department, Hospital Universitario Gregorio Marañón, Calle del Dr. Esquerdo, 46, 28007 Madrid, Spain. Electronic address:

Background: The ever-growing complexity of cancer-associated thrombosis (CAT), with new antineoplastic drugs and anticoagulants, distinctive characteristics, and decisions with low levels of evidence, justifies this registry.

Method: TESEO is a prospective registry promoted by the Spanish Society of Medical Oncology to which 34 centers contribute cases. It seeks to provide an epidemiological description of CAT in Spain. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.05.031DOI Listing

Direct oral anticoagulants versus vitamin K antagonists in antiphospholipid syndrome: A meta-analysis.

Eur J Intern Med 2020 May 29. Epub 2020 May 29.

Internal Medicine Department, Hospital Universitari Bellvitge - IDIBELL, Barcelona, Spain; Faculty of Medicine and Health Sciences, Universitat de Barcelona, Barcelona, Spain. Electronic address:

Background: Anticoagulant treatment is recommended in patients with thrombosis and antiphospholipid syndrome (APS). Conflicting results have been reported on the role of direct oral anticoagulants (DOACs) in these patients. We performed a meta-analysis of randomized controlled trials (RCTs) focused on this issue. Read More

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http://dx.doi.org/10.1016/j.ejim.2020.05.012DOI Listing

A risk as an infection route: Nasal colonization of methicillin-resistant Staphylococcus aureus USA300 clone among contact sport athletes in Japan.

J Infect Chemother 2020 May 29. Epub 2020 May 29.

Emergency and Critical Care Medicine, Tokyo Medical University Hachioji Medical Center, 1163 Tatemachi, Hachioji, Tokyo 193-0998, Japan.

Panton-Valentine leukocidin (PVL)-positive USA300 clone is a highly pathogenic and global epidemic community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) clone. Athletes are particularly vulnerable to CA-MRSA infection because of the frequency of skin trauma, close-contact situations, and sharing of equipment that is customary in the athletic setting. We experienced a case of Japanese collegiate football player with septic pulmonary emboli secondary to infectious iliofemoral deep venous thrombosis caused by the USA300 clone. Read More

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http://dx.doi.org/10.1016/j.jiac.2020.04.027DOI Listing

Thromboprophylaxis in elective spinal surgery: A protocol for systematic review.

Medicine (Baltimore) 2020 May;99(21):e20127

Iberoamerican Cochrane Centre, Sant Pau Biomedical Research Institute (IIB Sant Pau), CIBERESP, Barcelona, Spain.

Background: Venous thromboembolism (VTE) is a serious, sometimes life-threatening complication that can occur following spine surgery. The incidence of VTE, and the optimal type and timing of thromboprophylaxis for this complication in elective spine surgery is a matter of debate.

Objective: To perform a systematic review with the aim of clarifying the efficacy and adverse effects of mechanical and chemical prophylaxis for preventing thromboembolic complications in elective spine surgery for conditions other than trauma and malignant disease. Read More

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http://dx.doi.org/10.1097/MD.0000000000020127DOI Listing

Risk of venous thromboembolism in patients with idiopathic pulmonary fibrosis: a systematic review and meta-analysis.

Sarcoidosis Vasc Diffuse Lung Dis 2018 28;35(2):109-114. Epub 2018 Apr 28.

Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

Recent studies have suggested that patients with idiopathic pulmonary fibrosis (IPF) may have a higher risk of venous thromboembolism (VTE) compared to general population even though the results were inconsistent. To investigate the risk of VTE among patients with IPF. Comprehensive literature review using MEDLINE and EMBASE database were performed to identify studies that compared the risk of VTE among patients with IPF to general population. Read More

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http://dx.doi.org/10.36141/svdld.v35i2.6213DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7170087PMC

Risk of venous thromboembolism associated with totally implantable venous access ports in cancer patients: a systematic review and meta-analysis.

J Thromb Haemost 2020 Jun 1. Epub 2020 Jun 1.

Department of Internal Medicine, Hirslanden Clinic, Berne, Switzerland.

Background: Totally implantable venous access ports (TIVAPs) for chemotherapy are associated with venous thromboembolism (VTE). We aimed to quantify the incidence of TIVAPs associated VTE and compare it with external central venous catheters (CVCs) in cancer patients through a meta-analysis.

Methods: Studies reporting on VTE risk associated with TIVAP were retrieved from medical literature databases. Read More

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http://dx.doi.org/10.1111/jth.14930DOI Listing

A Case Series of MGUS and COVID-19.

Br J Haematol 2020 Jun 1. Epub 2020 Jun 1.

Department of Oncology, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.

Monoclonal Gammopathy of Undetermined Significance (MGUS) is a pre-malignant clonal plasma cell disorder, with 25 to 30% life-long risk of progression to multiple myeloma (MM). It is usually asymptomatic, but infrequently associated with several serious conditions, such as neuropathies, glomerulonephritis, and acquired angioedema. Moreover, a higher risk of infection and deep venous thrombosis has been reported in patients with MGUS. Read More

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http://dx.doi.org/10.1111/bjh.16906DOI Listing

Association between obesity and venous thromboembolism.

Med Pharm Rep 2020 Apr 22;93(2):162-168. Epub 2020 Apr 22.

2 Internal Medicine Department, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Background And Aims: Obesity is associated with numerous pathological conditions, including venous thromboembolism (VTE). VTE is a multifactorial disease; more than half of the hospitalized patients are at risk for VTE.We aimed to assess the risk of VTE associated with obesity, taking into account the class of obesity (according to the body mass index), gender, age and the intervention of other acquired risk factors. Read More

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http://dx.doi.org/10.15386/mpr-1372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7243888PMC

A Review of Temporary Permanent Pacemakers and a Comparison with Conventional Temporary Pacemakers.

J Innov Card Rhythm Manag 2019 May 15;10(5):3652-3661. Epub 2019 May 15.

Section of Electrophysiology & Pacing, Division of Cardiology, Department of Medicine, Baylor Scott & White Temple Memorial Hospital, Baylor Scott & White Health, Dallas, TX, USA.

Temporary cardiac pacing is commonly used in patients with life-threatening bradycardia and serves as a bridge to implantation of a permanent pacemaker (PPM). For years, passive fixation leads have been used for this purpose, offering the advantage of that they can be placed at bedside. The downside, however, is that patients must remain on telemetry and bed rest until lead removal due to the risk of displacement and failure to capture. Read More

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http://dx.doi.org/10.19102/icrm.2019.100506DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7252718PMC

Superficial venous thrombosis of the upper limb presenting to a chiropractic clinic: a case report.

J Can Chiropr Assoc 2020 Apr;64(1):76-81

Division of Clinical Education, Canadian Memorial Chiropractic College.

Objective: To present the clinical case of a patient with an upper extremity superficial venous thrombosis (SVT), and to highlight the importance for clinicians working in musculoskeletal care settings, to considered non-musculoskeletal causes for their patients' presentations.

Clinical Features: A 31-year-old male presented to an academic chiropractic clinic with progressive left sided tension over the medial arm, extending to the anterior aspect of his proximal forearm.

Intervention And Outcome: The patient was initially diagnosed with possible biceps/brachialis muscular strain and peripheral entrapment of the median nerve. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250507PMC

Acute kidney injury following percutaneous mechanical thrombectomy of subclavian artery stent graft thrombosis: a case report.

CVIR Endovasc 2020 Jun 1;3(1):27. Epub 2020 Jun 1.

Department of Diagnostic and Interventional Radiology, University Hospital Merkur, Zajceva ul.19, 10000, Zagreb, Croatia.

Background: Percutaneous mechanical thrombectomy (PMT) is a well-established technique for treatment of acute arterial and venous thrombosis which inevitably leads to intravascular erythrocyte hemolysis, resulting in hemoglobinuria.

Case Presentation: We present a case of 66-year-old Caucasian female with subclavian artery aneurysm causing distal embolization and hand ischemia. The aneurysm was treated with stent graft, but with a subsequent graft thrombosis 3 months later. Read More

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http://dx.doi.org/10.1186/s42155-020-00119-0DOI Listing

A REVIEW INTO THE MANAGEMENT OF MAY-THURNER SYNDROME IN ADOLESCENTS.

J Vasc Surg Venous Lymphat Disord 2020 May 28. Epub 2020 May 28.

Department of Vascular Surgery, Royal Blackburn Hospital, Haslingden Road, BB2 3HH.

Objective: To investigate the presentation, aetiology, management and outcomes of may-thurner syndrome in adolescents aged under 18.

Methods: We searched electronic bibliographic databases to identify published reports of May-thurner syndrome in patients under 18 years of age. We conducted our review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement standards. Read More

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http://dx.doi.org/10.1016/j.jvsv.2020.05.006DOI Listing

Non-Hodgkin's Lymphoma presenting as deep venous thrombosis; A case report with literature review.

Int J Surg Case Rep 2020 May 22;71:196-198. Epub 2020 May 22.

Kscien Organization, Hamdi Str, Azadi Mall, Sulaimani, Kurdistan, Iraq.

Introduction: Idiopathic deep venous thrombosis is a relatively common clinical finding. The aim of this article is to report and discuss a case of lymphoma presented as DVT in line with SCARE guidelines with brief literature review.

Case Report: A 19-year-old male presented with right lower limb swelling for two week duration. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260608PMC

Venous thromboembolic events in patients with brain metastases: the PICOS score.

Eur J Cancer 2020 May 27;134:75-85. Epub 2020 May 27.

Department of Neurology, Brain Tumor Center & Clinical Neuroscience Center, University Hospital and University of Zurich, Frauenklinikstrasse 26, CH-8091 Zurich, Switzerland.

Aim Of Study: Venous thromboembolic events (VTEs) are significant complications in patients with systemic malignancies. Thrombosis risk is poorly defined for patients with brain metastasis, and available risk calculation scores are not validated for these patients.

Methods: We identified 811 patients with brain metastasis followed at our institution and reviewed electronic charts retrospectively for the occurrence of VTEs, along with candidate risk factors. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.04.018DOI Listing

Role, Management, and Outcome of Free Flap Reconstruction for Acute Full-Thickness Burns in Hands.

Ann Plast Surg 2020 May 27. Epub 2020 May 27.

From the Department of Hand, Plastic and Reconstructive Surgery, Microsurgery-Burn Center, BG Trauma Center Ludwigshafen/Rhine, Hand and Plastic Surgery, University Heidelberg, Ludwigshafen, Germany.

Introduction: Severe thermal trauma to the hand can result in major impairment and reduced function due to defective healing or even extremity loss. Full-thickness injuries frequently incur exposure of tendons or bone and require an early and stable coverage with soft tissue transplants to allow for rapid induction of exercise and to preserve structures and hand function. Free tissue transfer to the hand after thermal trauma is a rare indication, and safety, management, and outcome of free flap surgery for severe acute burn injuries to the hand remains underreported. Read More

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http://dx.doi.org/10.1097/SAP.0000000000002412DOI Listing

Sonographic evolution of the superficial vein thrombosis of the lower extremity.

J Ultrasound 2020 May 29. Epub 2020 May 29.

Department of Internal Medicine, Hospital Universitario La Paz, Madrid, Spain.

Background: Superficial venous thrombosis (SVT) is a common clinical problem across various treatment settings. SVT shares risk factors with deep venous thrombosis (DVT) and carries a risk of thromboembolic complications, greater than previously expected. Little is known about the pathophysiology, resolution and recurrence of this disease. Read More

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http://dx.doi.org/10.1007/s40477-020-00482-7DOI Listing

Association between factor V Leiden mutation and recurrent pregnancy loss in the middle east countries: a Newcastle-Ottawa meta-analysis.

Arch Gynecol Obstet 2020 May 29. Epub 2020 May 29.

Department of Laboratory Medicine and Pathology, University of Alberta, WMC 5B4.09, 8440 112 ST NW, Edmonton, AB, Canada.

Purpose: Heritable thrombophilia is a category of genetic disorders of the coagulation cascade with the increasing risk of thrombus formation and recurrent pregnancy loss (RPL). Factor V Leiden (FVL) (R506Q) mutation is the most common genetic cause of deep venous thrombosis, but its association with RPL has been inconsistent in studies arising from non-Western countries. The present metanalysis was aimed to determine whether an association exists between FVL and RPL in the Middle East. Read More

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http://dx.doi.org/10.1007/s00404-020-05610-6DOI Listing

Venous Thoracic Outlet Syndrome in a Young Student.

J Emerg Med 2020 May 26. Epub 2020 May 26.

Department of Emergency Medicine, The Ohio State University, Columbus, Ohio.

Background: Venous thoracic outlet syndrome (VTOS) results from compression and thrombosis of the axillosubclavian vein. In primary effort thrombosis, a subtype of VTOS, chronic repetitive compression injury of the axillosubclavian vein leads to scarring, stenosis, and eventually, thrombosis. This is a rare manifestation of an upper extremity deep vein thrombosis. Read More

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http://dx.doi.org/10.1016/j.jemermed.2020.04.044DOI Listing

[Frequency and predictive factors of venous thrombosis in Behçet's disease].

Rev Med Interne 2020 May 26. Epub 2020 May 26.

Service de médecine interne, centre hospitalier universitaire Mohammed-VI Marrakech, Marrakech, Maroc.

Objective: To investigate the clinical features of venous thrombosis in patients with Behçet's disease and to determine the patients at high risk for this complication.

Methods: We retrospectively studied patients with venous thrombosis (n = 157) who were followed up in the Internal Medicine department. These patients were divided into two groups according to the existence (n = 60, 38. Read More

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http://dx.doi.org/10.1016/j.revmed.2020.03.010DOI Listing

Acute pulmonary embolism in COVID-19 disease: Preliminary report on seven patients.

Int J Cardiol 2020 Apr 24. Epub 2020 Apr 24.

Department of Radiological Sciences, Spedali Civili and University of Brescia, Italy.

There is some evidence that Covid 19 pneumonia is associated with prothrombotic status and increased risk of venous thromboembolic events (deep venous thrombosis and pulmonary embolism). Over a two-week period we admitted in our Unit 25 patients with Covid-19 pneumonia, of these pulmonary embolism was diagnosed using computed tomography angiography in 7. We report on clinical and biochemical features of these patients. Read More

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http://dx.doi.org/10.1016/j.ijcard.2020.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250100PMC

Is Carbon Monoxide Poisoning a Risk Factor or a Bystander of Deep Venous Thrombosis?

Ann Emerg Med 2020 06;75(6):781-782

Department of Neurology, Affiliated Dongyang Hospital of Wenzhou Medical University, Dongyang, Zhejiang, People's Republic of China.

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http://dx.doi.org/10.1016/j.annemergmed.2020.01.032DOI Listing

MR Imaging of the Mesenteric Vasculature.

Authors:
Jeremy D Collins

Radiol Clin North Am 2020 Jul 12;58(4):797-813. Epub 2020 May 12.

Department of Radiology, Mayo Clinic, 200 First Street Southwest, Rochester, MN 55901, USA. Electronic address:

MR angiography is a flexible imaging technique enabling morphologic assessment of mesenteric arterial and venous vasculature. Conventional gadolinium-based contrast media and ferumoxytol are used as contrast agents. Ferumoxytol, an intravenous iron replacement therapy approved by the US Food and Drug Administration for iron deficiency anemia, is an effective and well tolerated blood pool contrast agent. Read More

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http://dx.doi.org/10.1016/j.rcl.2020.03.001DOI Listing

A Safe Transitions Pathway for post-craniotomy neurological surgery patients: high-value care that bypasses the intensive care unit.

J Neurosurg 2020 May 29:1-6. Epub 2020 May 29.

1Department of Neurological Surgery and.

Objective: High-value medical care is described as care that leads to excellent patient outcomes, high patient satisfaction, and efficient costs. Neurosurgical care in particular can be expensive for the hospital, as substantial costs are accrued during the operation and throughout the postoperative stay. The authors developed a "Safe Transitions Pathway" (STP) model in which select patients went to the postanesthesia care unit (PACU) and then the neuro-transitional care unit (NTCU) rather than being directly admitted to the neurosciences intensive care unit (ICU) following a craniotomy. Read More

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http://dx.doi.org/10.3171/2020.3.JNS192133DOI Listing

Myocardial Infarction with Limb Arterial and Venous Thrombosis in a Patient with Enoxaparin-Induced Thrombocytopenia.

Am J Case Rep 2020 May 29;21:e922498. Epub 2020 May 29.

Department of Medicine, Division of Hematology and Oncology, State University New York (SUNY) Downstate Medical Center, Brooklyn, NY, USA.

BACKGROUND Heparin, often used as an anticoagulant, acts by binding to antithrombin III. Indeed, heparin binds to a variety of proteins other than antithrombin III. Among them, platelet factor 4 can bind and neutralize the anticoagulant activity of heparin. Read More

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http://dx.doi.org/10.12659/AJCR.922498DOI Listing