198,490 results match your criteria Deep Neck Infections


Completeness of circle of Willis and white matter hyperintensities in patients with severe internal carotid artery stenosis.

Neurol Sci 2018 Dec 15. Epub 2018 Dec 15.

Cerebrovascular Disease Center, Department of Neurology, People's Hospital, China Medical University, 33 Wenyi Road, Shenhe District, Shenyang, 110016, People's Republic of China.

Background: We investigated whether completeness of the circle of Willis (CoW) protected patients with severe internal carotid artery (ICA) stenosis against white matter hyperintensities (WMHs).

Methods: We included 115 patients with unilateral ICA stenosis ≥ 70%. The completeness of CoW was assessed and WMHs were rated on a visual scale. Read More

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December 2018

Visualization technologies for 5-ALA-based fluorescence-guided surgeries.

J Neurooncol 2018 Dec 15. Epub 2018 Dec 15.

Department of Mechanical Engineering, University of Washington, Seattle, WA, 98195, USA.

Introduction: 5-ALA-based fluorescence-guided surgery has been shown to be a safe and effective method to improve intraoperative visualization and resection of malignant gliomas. However, it remains ineffective in guiding the resection of lower-grade, non-enhancing, and deep-seated tumors, mainly because these tumors do not produce detectable fluorescence with conventional visualization technologies, namely, wide-field (WF) surgical microscopy.

Methods: We describe some of the main factors that limit the sensitivity and accuracy of conventional WF surgical microscopy, and then provide a survey of commercial and research prototypes being developed to address these challenges, along with their principles, advantages and disadvantages, as well as the current status of clinical translation for each technology. Read More

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December 2018

Deep sequencing salivary proteins for periodontitis using proteomics.

Clin Oral Investig 2018 Dec 15. Epub 2018 Dec 15.

Department of Preventive and Social Dentistry, School of Dentistry, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul, 03080, South Korea.

Objectives: Saliva is a bodily fluid transuded from gingival crevice fluid and blood and contains many proteins. Proteins in saliva have been studied as markers for periodontal diseases. Mass spectrometric analysis is applied to investigate biomarker proteins that are related to periodontitis. Read More

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December 2018

Clinically applicable delineation of the pallidal sensorimotor region in patients with advanced Parkinson's disease: study of probabilistic and deterministic tractography.

Authors:

J Neurosurg 2018 Dec 14:1-12. Epub 2018 Dec 14.

OBJECTIVEDeep brain stimulation (DBS) is an effective procedure in improving motor symptoms for patients with advanced Parkinson's disease (PD) through the use of high-frequency stimulation. Although one of the most commonly used target sites for DBS, sensorimotor regions of the globus pallidus interna (GPi) have yet to be thoroughly described with advanced neuroimaging analysis in vivo for human subjects. Furthermore, many imaging studies to date have been performed in a research setting and bring into question the feasibility of their applications in a clinical setting, such as for surgical planning. Read More

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December 2018

In-situ forming gels containing fluorometholone-loaded polymeric nanoparticles for ocular inflammatory conditions.

Colloids Surf B Biointerfaces 2018 Nov 27;175:365-374. Epub 2018 Nov 27.

Department of Pharmacy, Pharmaceutical Technology and Physical Chemistry, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028, Barcelona, Spain; Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, Barcelona, Spain. Electronic address:

Thermosensitive gels have been developed and optimized in such a way that they become gels at corneal temperature and with a viscosity that allows the adequate release of the Fluorometholone (FMT)-loaded PLGA nanoparticles (NPs) in order to improve ocular anti-inflammatory efficacy against a commercial formulation. It has been shown that gels avoid burst release of the drug in the first hours with a slow and increasing profile after administration. NPs have maintained their average size and spherical shape within the gels as confirmed by transmission electron microscopy (TEM). Read More

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November 2018
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Proteomics turns functional.

J Proteomics 2018 Dec 13. Epub 2018 Dec 13.

Department of Science and High Technology, Center of Bioinformatics, University of Insubria, Busto Arsizio, Italy. Electronic address:

Proteomics is acquiring a pivotal role in the comprehensive understanding of human biology. Biochemical processes involved in complex diseases, such as neurodegenerative diseases, diabetes and cancer, can be identified by combining proteomics analysis and bioinformatics tools. In the last ten years, the main output of differential proteomics investigations evolved from long lists of proteins to the generation of new hypotheses and their functional verification. Read More

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December 2018

Using a deep learning algorithm and integrated gradients explanation to assist grading for diabetic retinopathy.

Ophthalmology 2018 Nov 28. Epub 2018 Nov 28.

Google Research, Google Inc, Mountain View, CA, USA.

Objective: To understand the impact of deep learning diabetic retinopathy (DR) algorithms on physician readers in computer-assisted settings.

Design: Evaluation of diagnostic technology PARTICIPANTS: 1,796 retinal fundus images from 1,612 diabetic patients.

Methods: 10 ophthalmologists (5 general ophthalmologists, 4 retina specialists, 1 retina fellow) read images for DR severity based on the International Clinical Diabetic Retinopathy disease severity scale in one of 3 conditions: Unassisted, Grades Only, or Grades + Heatmap. Read More

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November 2018

Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: Relationship between the electrode trajectory and cognitive decline.

Parkinsonism Relat Disord 2018 Dec 8. Epub 2018 Dec 8.

Department of Psychology, University of Turin, Via Verdi, 8 - 10124, Turin, Italy.

Introduction: It remains to be clarified whether penetration of the caudate nucleus increases the risk of cognitive decline in patients with Parkinson's disease (PD) undergoing deep brain stimulation (DBS) of the subthalamic nucleus (STN).

Methods: A retrospective analysis of pre/postoperative neuropsychological changes was performed with 46 consecutive patients with PD who underwent DBS of the STN. In particular, to evaluate the possible relationship between cognitive changes and DBS lead trajectories, repeated-measures ANCOVAs were conducted to analyze the effects of group (23 patients with vs 23 patients without penetration of the caudate nucleus) and time (T0 vs T1) for each neuropsychological test. Read More

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December 2018

An overview of deep learning in medical imaging focusing on MRI.

Z Med Phys 2018 Dec 12. Epub 2018 Dec 12.

Mohn Medical Imaging and Visualization Centre (MMIV), Haukeland University Hospital, Norway; Neuroinformatics and Image Analysis Laboratory, Department of Biomedicine, University of Bergen, Norway; Department of Health and Functioning, Western Norway University of Applied Sciences, Norway. Electronic address:

What has happened in machine learning lately, and what does it mean for the future of medical image analysis? Machine learning has witnessed a tremendous amount of attention over the last few years. The current boom started around 2009 when so-called deep artificial neural networks began outperforming other established models on a number of important benchmarks. Deep neural networks are now the state-of-the-art machine learning models across a variety of areas, from image analysis to natural language processing, and widely deployed in academia and industry. Read More

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December 2018

Seventeen to Twenty Years of Follow-Up of the Low Contact Stress Rotating-Platform Total Knee Arthroplasty With a Cementless Tibia in All Cases.

J Arthroplasty 2018 Nov 23. Epub 2018 Nov 23.

Outcomes Unit, Primary Joint Unit, Department of Orthopaedics, Musgrave Park Hospital, Belfast, United Kingdom.

Background: Total knee arthroplasty designs can be categorized by bearing design and fixation method. The mobile-bearing concept was developed with the aim of increasing longevity and improving function by reduced polyethylene wear and closer replication of physiological knee motion. Cementless fixation has the goal of achieving a long-lasting "biological" fixation between prosthesis and bone. Read More

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November 2018

Preparation of hydroxylated lecithin complexed iodine/carboxymethyl chitosan/sodium alginate composite membrane by microwave drying and its applications in infected burn wound treatment.

Carbohydr Polym 2019 Feb 29;206:435-445. Epub 2018 Oct 29.

Agriculture Products Processing Research Institute, Chinese Academy of Tropical Agricultural Sciences, Zhanjiang, 524001, PR China.

Improving the antibacterial properties of membrane wound dressings of natural polymers is crucial. Iodine is an important safe inorganic antibacterial agent, but was confined in the composition with polymer membranes due to the challenges of homogeneity and stability during drying. In the present work, iodine was complexed with hydroxylated lecithin (HL) to improve its stability and complexing efficiency for the composition with carboxymethly chitosan/sodium alginate. Read More

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February 2019

A centrifuge method to determine the solid-liquid phase behavior of eutectic mixtures.

J Chem Phys 2018 Dec;149(22):224505

Laboratory of Physical Chemistry, Department of Chemical Engineering and Chemistry, Eindhoven University of Technology, Het Kranenveld, Building 14 (Helix), 5612 AZ Eindhoven, The Netherlands.

The centrifuge method is a novel, equilibrium-based, analytical procedure that allows the construction of solid-liquid phase diagrams of binary eutectic mixtures. In this paper, the development, optimization, and successful verification of the centrifuge method are described. Contrary to common dynamic analysis techniques-differential scanning calorimetry and hot-stage microscopy-the studied mixtures are equilibrated at constant temperature. Read More

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December 2018

Gut microbiota-dependent trimethylamine-N-oxide (TMAO) shows a U-shaped association with mortality but not with recurrent venous thromboembolism.

Thromb Res 2018 Dec 6;174:40-47. Epub 2018 Dec 6.

Center for Molecular Cardiology, Laboratory for Platelet Research, University of Zurich, Schlieren, Switzerland; Department of Internal Medicine, Cantonal Hospital of Baden, Baden, Switzerland. Electronic address:

Introduction: Gut microbiota-dependent trimethylamine-N-oxide (TMAO) correlates with arterial thrombotic events including myocardial infarction and stroke, and mortality. However, the association of TMAO with recurrent venous thromboembolism (VTE) and mortality remains unknown.

Methods: TMAO plasma levels were assessed by high performance liquid chromatography in 859 patients aged ≥65 years with acute VTE and categorized into low (<2. Read More

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December 2018
2 Reads

Post-thrombotic syndrome and recurrent thromboembolism in patients with upper extremity deep vein thrombosis: A systematic review and meta-analysis.

Thromb Res 2018 Dec 8;174:34-39. Epub 2018 Dec 8.

Department of Medicine, Division of Hematology, Western University, London, ON, Canada; Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. Electronic address:

Introduction: There is limited data on the occurrence of complications in patients with upper extremity deep vein thrombosis (UEDVT).

Aims: We aimed to determine the frequency of post-thrombotic syndrome (PTS), thrombosis recurrence and major bleeding (MB) in patients with UEDVT.

Material And Methods: We conducted a systematic review of the literature including studies from 1970 onwards. Read More

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December 2018
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Establishing a decision-support system for eco-design of biological wastewater treatment: A case study of bioaugmented constructed wetland.

Bioresour Technol 2018 Dec 7;274:425-429. Epub 2018 Dec 7.

Section of Sanitary Engineering, Department of Water Management, Delft University of Technology, Delft 2628CN, The Netherlands; Veolia Water Technologies Techno Center Netherlands B.V., Tanthofdreef 21, 2623 EW Delft, The Netherlands.

Deep treatment is a common approach to enhance pollutant removal for biological wastewater treatment technologies (BWTTs), and life cycle assessment (LCA) holds substantial advantages to support process optimization. However, there lacks of LCA-based benchmarks that cover human-nature nexuses and stakeholder involvement, which limits the guidance and eco-design of BWTTs. This study proposed a decision-support system (DSS) by linking LCA with Water Quality Model and Conjoint Analysis. Read More

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December 2018
2 Reads

On the (Non-)equivalency of monopolar and bipolar settings for deep brain stimulation fMRI studies of Parkinson's disease patients.

J Magn Reson Imaging 2018 Dec 15. Epub 2018 Dec 15.

GE Global Research Center, Bangalore, India.

Background: The majority of Parkinson's disease patients with deep brain stimulation (DBS) use a monopolar configuration, which presents challenges for EEG and MRI studies. The literature reports algorithms to convert monopolar to bipolar settings.

Purpose/hypothesis: To assess brain responses of Parkinson's disease patients implanted with DBS during fMRI studies using their clinical and presumed equivalent settings using a published conversion recipe. Read More

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December 2018

The composition and structure of the intestinal microflora of Anguilla marmorata at different growth rates: a deep sequencing study.

J Appl Microbiol 2018 Dec 15. Epub 2018 Dec 15.

Jimei University, Xiamen, 361021, China.

Aims: The aim of this study was to determine the intestinal microflora of Anguilla marmorata at different growth rates and to identify potential probiotic/pernicious bacteria.

Methods And Results: Bacterial communities from 8 different fish intestinal sites (including the intestinal contents and the intestinal mucosa) from three fish groups (3 fast-, 2 medium-, and 3 stunted-growth samples), 2 water samples, and 1 diet sample were characterized by Illumina next-generation sequencing. The data revealed that the predominant genera (relative abundance of bacteria genera >1%) in the intestine of fast- and medium-growth groups were Cetobacterium, Edwardsiella, Clostridium, Lactococcus, Bacteroides, Plesiomonas, and Akkermansia. Read More

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December 2018

First-principles study of Aziridinium Lead Iodide Perovskite for Photovoltaics.

Chemphyschem 2018 Dec 15. Epub 2018 Dec 15.

South China University of Technology, Department of Physics, 381 Wushan Rd., 510640, Guangzhou, CHINA.

Long term stability remains one of the main challenges for the commercialization of rapidly developing hybrid organic-inorganic perovskite solar cells. Herein, we investigate the electronic and optical properties of a recently reported a much better stability hybrid halide perovskite (CH2)2NH2PbI3 (AZPbI3) than popular halide perovskits CH3NH3PbI3 and HC(NH2)2PbI3, using the density functional theory (DFT). We find that AZPbI3 possesses a band gap of 1. Read More

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December 2018

Comparative risk of venous thromboembolism with tofacitinib versus tumor necrosis factor inhibitors: A cohort study of rheumatoid arthritis patients.

Arthritis Rheumatol 2018 Dec 15. Epub 2018 Dec 15.

Division of Pharmacoepidemiology and Pharmacoeconomics, Brigham and Women's Hospital & Harvard Medical School, Boston, MA, USA.

Objective: To evaluate the risk of venous thromboembolism (VTE) with tofacitinib versus tumor necrosis factor (TNF)-inhibitors in rheumatoid arthritis (RA) patients.

Methods: RA patients initiating tofacitinib or a TNF inhibitor without use of any biologic or tofacitinib any time prior were identified from Truven MarketScan (2012-2016) or Medicare claims (parts A, B, and D, 2012-2015) and followed until treatment discontinuation, treatment switch, insurance disenrollment, or administrative censoring. The outcome of VTE was identified using inpatient claims for pulmonary embolism or deep vein thrombosis. Read More

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December 2018

Alternative Design for Anterolateral Thigh Multi-Paddled Flaps: The 3-5 System.

Med Sci Monit 2018 Dec 15;24:9102-9109. Epub 2018 Dec 15.

Department of Plastic Surgery, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China (mainland).

BACKGROUND The design and harvest of the anterolateral thigh (ALT) multi-paddled flap is a critical step in reconstructive surgeries. However, limited perforator distribution patterns of traditional design methods have gradually emerged in clinical practice. The aim of this study was to investigate the effect of a new technique (the 3-5 system) on ALT multi-paddled flap design. Read More

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December 2018

Maternal and offspring MTHFR genotypes interact in a mouse model to induce ASD-like behavior.

Genes Brain Behav 2018 Dec 15:e12547. Epub 2018 Dec 15.

Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.

Individuals with autism constitute a variable population whose members are spread along the autism spectrum. Sub-populations within that spectrum exhibit other conditions, such as anxiety, intellectual disabilities, hyperactivity and epilepsy, with different severities and co-occurrences. Among the genes associated with the increased risk for autism is the methylenetetrahydrofolate-reductase (MTHFR) 677C>T polymorphism, which impairs one-carbon metabolic pathway efficiency. Read More

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December 2018

Moonshot to Cancer Cure: Recruiting Policy to Break Down Silos.

Cancer Treat Res 2019 ;171:119-128

Robert H. Lurie Comprehensive Cancer Center, Survivorship Institute, Northwestern University, Chicago, IL, 60611, USA.

Funded by the 21 Century Cures Act, The Beau Biden Cancer Moonshot Initiative is broad, deep, integrative, and intended to expediently address cancer's most vexing problems. Launched in 2015, it is an effort to accelerate the pace of cancer research with a focus on breaking down silos through cross-pollination of research, recruitment of multidisciplinary clinical and basic science research teams, sharing of complex scientific databases, and the creation of public-private research partnerships. This audacious approach to cancer treatment is intended to alleviate the current burden of cancer within countries and across borders. Read More

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January 2019
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Patient 3D body pose estimation from pressure imaging.

Int J Comput Assist Radiol Surg 2018 Dec 14. Epub 2018 Dec 14.

Computer Aided Medical Procedures, Technische Universität München, Boltzmannstr 3, 85748, Garching, Germany.

Purpose: In-bed motion monitoring has become of great interest for a variety of clinical applications. Image-based approaches could be seen as a natural non-intrusive approach for this purpose; however, video devices require special challenging settings for a clinical environment. We propose to estimate the patient's posture from pressure sensors' data mapped to images. Read More

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December 2018
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Positive influence of simvastatin used as adjuvant agent for cavity lining.

Clin Oral Investig 2018 Dec 14. Epub 2018 Dec 14.

Department of Physiology and Pathology, Araraquara School of Dentistry, São Paulo State University (Unesp), Rua Humaitá, 1680, Araraquara, SP, 14801-903, Brazil.

Objectives: To assess the biological, antimicrobial, and mechanical effects of the treatment of deep dentin with simvastatin (SV) before application of a glass-ionomer cement (GIC).

Materials And Methods: Dentin discs were adapted to artificial pulp chambers and SV (2.5 or 1. Read More

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December 2018

Secretory Expression of a Chimeric Peptide in Lactococcus lactis: Assessment of its Cytotoxic Activity and a Deep View on Its Interaction with Cell-Surface Glycosaminoglycans by Molecular Modeling.

Probiotics Antimicrob Proteins 2018 Dec 14. Epub 2018 Dec 14.

Department of Animal Sciences, Faculty of Agriculture, Ferdowsi University of Mashhad, Mashhad, Iran.

Nowadays, cancer remains a major cause of death affecting millions of people. Currently, the antimicrobial peptides (AMPs) as potent anticancer therapeutic agents offer specificity and low levels of side effects in cancer therapy. In the present study, a cationic chimeric peptide (cLFchimera), derived from camel lactoferrin, was expressed as a secretory peptide using P170 expression system in L. Read More

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December 2018
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From deep learning to transfer learning for the prediction of skeletal muscle forces.

Authors:
Tien Tuan Dao

Med Biol Eng Comput 2018 Dec 14. Epub 2018 Dec 14.

Sorbonne University, Université de Technologie de Compiègne, CNRS, UMR 7338 Biomechanics and Bioengineering, Centre de recherche Royallieu, Compiègne Cedex, France.

Skeletal muscle forces may be estimated using rigid musculoskeletal models and neural networks. Neural network (NN) approach has the advantages of real-time estimation ability and promising prediction accuracy. However, most of the developed NN models are based on conventional feedforward NNs, which do not take dynamic temporal relationships of the muscle force profiles into consideration. Read More

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December 2018

Deep sequencing and transcriptome analysis to identify genes related to biosynthesis of aristolochic acid in Asarum heterotropoides.

Sci Rep 2018 Dec 14;8(1):17850. Epub 2018 Dec 14.

Traditional Chinese Medicine College, Jilin Agricultural University, Changchun City, Jilin Province, 130118, China.

Asarum spp. are important medicinal plants that have the potential for use in treating various types of fevers. Aristolochic acid is one of the main toxic compounds present in these plants. Read More

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December 2018
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Constructing exact representations of quantum many-body systems with deep neural networks.

Nat Commun 2018 Dec 14;9(1):5322. Epub 2018 Dec 14.

Department of Applied Physics, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8656, Japan.

Obtaining accurate properties of many-body interacting quantum matter is a long-standing challenge in theoretical physics and chemistry, rooting into the complexity of the many-body wave-function. Classical representations of many-body states constitute a key tool for both analytical and numerical approaches to interacting quantum problems. Here, we introduce a technique to construct classical representations of many-body quantum systems based on artificial neural networks. Read More

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December 2018

Selective carious tissue removal using subjective criteria or polymer bur: study protocol for a randomised controlled trial (SelecCT).

BMJ Open 2018 Dec 14;8(12):e022952. Epub 2018 Dec 14.

Department of Dentistry, School of Health Sciences, University of Brasília, Brasilia, Brazil.

Introduction: Selective (incomplete/partial) carious tissue removal is suitable for treating deep carious lesions in teeth with vital, asymptomatic pulps. In the periphery of a cavity, removal to hard dentin is performed, while in pulpo-proximal areas, leathery or soft dentin is left to avoid pulp exposure. As the decision of what contains 'soft' or 'leathery' dentin is subjective, using self-limiting burs which help to standardise the hardness of the remaining dentin, has been suggested to increase the reliability of carious tissue removal. Read More

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December 2018

Obinutuzumab pretreatment abrogates tumor lysis risk while maintaining undetectable MRD for venetoclax + obinutuzumab in CLL.

Blood Adv 2018 Dec;2(24):3566-3571

Internal Medicine, Albert Schweitzer Hospital, Dordrecht, The Netherlands.

Early data on venetoclax-containing regimens for the treatment of chronic lymphocytic leukemia (CLL) show promising results with deep remissions, but are hampered by potential risk for tumor lysis syndrome (TLS). Whether optimal duration of venetoclax treatment can be guided by minimal residual disease (MRD) is currently unknown. To study whether TLS risk can be mitigated in an unfit population by introducing preinduction, and whether MRD-guided duration of venetoclax treatment is a feasible and efficacious approach, we performed the Dutch-Belgian Cooperative Trial Group for Hemato-oncology (HOVON) 139/GIVE trial. Read More

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December 2018

Posteromedial rotatory incongruity of the elbow: a computational kinematics study.

J Shoulder Elbow Surg 2018 Dec 12. Epub 2018 Dec 12.

Department of Orthopaedic Surgery, University of Missouri-Kansas City, Kansas City, MO, USA.

Background: Our objective was to analyze the effect of different anteromedial coronoid fracture patterns with different combinations of ligamentous repairs. We hypothesized that smaller fractures would be sufficiently treated with ligamentous repair alone but that larger fragments would require a combination of ligament and bony repair versus reconstruction.

Methods: Two multibody models were created from cadaveric specimens in the ADAMS program. Read More

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December 2018

Penile Prosthesis Reservoir Removal: Surgical Description and Patient Outcomes.

J Sex Med 2018 Dec 11. Epub 2018 Dec 11.

Division of Urology, Rutgers New Jersey Medical School, East Orange, NJ, USA. Electronic address:

Background: Removal of the penile prosthesis reservoir can be technically challenging because of its difficult locations either deep in the pelvis or high in the abdominal wall.

Aim: To describe a detailed surgical technique for reservoir removal through a penoscrotal approach.

Methods: We describe our preferred method for removal of prosthetic reservoir and present a retrospective review of patient outcomes after reservoir removal. Read More

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December 2018
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Quantitative analyses of amount and localization of radiosensitizer gold nanoparticles interacting with cancer cells to optimize radiation therapy.

Biochem Biophys Res Commun 2018 Dec 11. Epub 2018 Dec 11.

Department of Medical Physics, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, 980-8575, Japan. Electronic address:

Previous studies showed that gold nanoparticles (AuNPs) are useful radiosensitizers which optimize radiation therapy under low-dose radiation. However, the mechanisms of AuNP radiosensitization, including the amount and localization of the AuNPs interacting with cancer cells, has not yet been quantified. To answer these questions, we prepared AuNPs conjugated with anti-human epidermal growth factor receptor type 2 (HER2) antibody via polyethylene glycol (PEG) chains (AuNP-PEG-HER2ab). Read More

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December 2018

Implant-related sepsis in lower limb fractures following gunshot injuries in the civilian population: A systematic review.

Injury 2018 Dec 5. Epub 2018 Dec 5.

Division of Orthopaedics, Department of Surgical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, South Africa; Countess of Chester Hospital, Chester, UK.

Introduction: The management of long bone lower limb fractures secondary to gunshot wounds (GSWs) in the civilian setting are complex and there is currently no consensus regarding the optimal approach to managing such fractures. This study aims to address the relationship of implant related sepsis in fractures secondary to GSWs.

Methods: A systematic review of the literature was performed on both Pubmed and Scopus databases that look at fractures caused by GSWs in the lower limb. Read More

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December 2018

Non-Coding RNA in Pancreas and β-Cell Development.

Noncoding RNA 2018 Dec 13;4(4). Epub 2018 Dec 13.

Department of Science and Environment, Roskilde University, DK-4000 Roskilde, Denmark.

In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. Read More

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December 2018

Metformin inhibits estradiol and progesterone-induced decidualization of endometrial stromal cells by regulating expression of progesterone receptor, cytokines and matrix metalloproteinases.

Biomed Pharmacother 2019 Jan 15;109:1578-1585. Epub 2018 Nov 15.

Center of Reproductive Medicine, The Affiliated Wuxi Matemity and Child Health Care Hospital of Nanjing Medical University, China.

Background: Polycystic ovary syndrome (PCOS) is a serious threat for reproductive-aged women. Metformin has been used for the treatment of PCOS. However, its molecular mechanism in decidualization process of PCOS has not been well featured. Read More

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January 2019

Deep Brain Stimulation in Early Parkinson's Disease May Slow Rest Tremor Progression.

Neurosurgery 2019 Jan;84(1):E13-E14

Department of Neurological Surgery University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania.

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January 2019

Origin of neck pain and direction of movement influence dynamic cervical joint motion and pressure pain sensitivity.

Clin Biomech (Bristol, Avon) 2018 Dec 5;61:120-128. Epub 2018 Dec 5.

Center for Neuroplasticity and Pain (CNAP), SMI, Department of Health and Science Technology, Faculty of Medicine, Aalborg University, Denmark.

Background: Patients with neck pain normally showed alterations in cervical motion and pressure pain sensitivity. Cervical joints show scattered motions opposite to (anti-directional) the primary motion direction (pro-directional) during dynamic cervical flexion and extension. This study aimed to assess dynamic cervical joint motion and pressure pain sensitivity when pain originated from different cervical muscles which may have clinical relevance in diagnosis of impairments related with neck pain. Read More

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December 2018

Designing luminescent ruthenium prodrug for precise cancer therapy and rapid clinical diagnosis.

Biomaterials 2018 Dec 5;192:579-589. Epub 2018 Dec 5.

The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China; Department of Chemistry, Jinan University, Guangzhou, 510632, China. Electronic address:

The effective design of a targeted drug delivery system could improve the therapeutic efficacy of anticancer drugs by reducing their undesirable adsorption and toxic side effects. Here, an RGD-peptide functionalized and bioresponsive ruthenium prodrug (Ru-RGD) was designed for both cancer therapy and clinical diagnosis. This prodrug can be selectively delivered to cervical tumor sites to enhance theranostic efficacy. Read More

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December 2018
2 Reads

Odorous compounds sources and transport from a swine deep-pit finishing operation: A case study.

J Environ Manage 2018 Dec 11;233:12-23. Epub 2018 Dec 11.

USDA Agricultural Research Service, National Laboratory for Agriculture and the Environment, 1015 N. University Boulevard, Ames, IA, 50011, United States.

Odor emissions from swine finishing operations are an air quality issue that affects residents at the local level. A study was conducted at a commercial swine deep-pit finishing operation in central Iowa to monitor odorous compounds emitted and transported offsite. Gaseous compounds were sampled using either sorbent tubes or canisters with GC/MS analysis, and particulates matter (PM) were sampled with high volume samplers and thermally extracted onto sorbent tubes for GC/MS analysis. Read More

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December 2018
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Combining land preparation and vegetation restoration for optimal soil eco-hydrological services in the Loess Plateau, China.

Sci Total Environ 2018 Dec 3;657:535-547. Epub 2018 Dec 3.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Department of Sediment Research, China Institute of Water Resource and Hydropower Research, Beijing 100048.

In semiarid terrestrial ecosystems, optimized eco-rehabilitation strategies, such as land preparations and planting vegetation, are keys to achieve a successful ecological restoration. Land preparations and vegetation are supposed to have the coupled and respective impacts on soil ecosystem services, which are still unclear now. In this study, eighteen experimental plots with six different combinations and repetitions of land preparations and vegetation were built in the Chinese Loess Plateau in 2014 and soil moisture storages (SMS), soil carbon stocks (SCS) and other soil nutrient stocks were calculated at 0-100 cm, also the effects of land preparations and planting vegetation on soil eco-hydrological services are analyzed by mathematical methods. Read More

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December 2018

Advanced chemical peels: phenol-croton oil peel.

J Am Acad Dermatol 2018 Dec 11. Epub 2018 Dec 11.

Department of Dermatology, Emory University School of Medicine, Atlanta, GA.

Once considered the gold standard for deep facial resurfacing, the classical Baker-Gordon phenol-croton oil peel has largely been replaced by formulas with lower concentrations of phenol and croton oil. The improved safety profile of deep peels has ushered in a new era in chemical peeling. Wrinkles can be improved and skin tightened with more subtle and natural results. Read More

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December 2018
2 Reads

Diabetic Nonperfused Areas in Macular and Extramacular Regions on Wide-Field Optical Coherence Tomography Angiography.

Invest Ophthalmol Vis Sci 2018 Dec;59(15):5893-5903

Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.

Purpose: To investigate the nonperfused areas (NPAs) in each subfield segmented by large arterioles on wide-field swept-source optical coherence tomography angiography (SS-OCTA) images in diabetic retinopathy.

Methods: We retrospectively reviewed 101 consecutive eyes of 67 patients with severe nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR), for whom 12 × 12-mm SS-OCTA images centered on the optic disc were acquired. Both eyes were included in 34 patients. Read More

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December 2018

VESSEL DENSITY OF SUPERFICIAL, INTERMEDIATE, AND DEEP CAPILLARY PLEXUSES USING OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY.

Retina 2018 Dec 6. Epub 2018 Dec 6.

Service d'Ophtalmologie, Hôpital Lariboisière, AP-HP, Assistance Publique-Hôpitaux de Paris, Université Paris Diderot, Sorbonne Paris Cité, France.

Purpose: To provide values of retinal vessel density (VD) in the three retinal capillary plexuses, foveal avascular zone (FAZ) area, and retinal layer thickness in a cohort of healthy subjects.

Methods: The optical coherence tomography angiography maps of 148 eyes of 84 healthy subjects, aged 22 to 76 years, were analyzed for measuring VD of the retinal capillary plexuses, using the Optovue device comprising a projection artifact removal algorithm. Foveal avascular zone metrics were measured, and the relationship between optical coherence tomography angiography findings and age, sex, and image quality was studied. Read More

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December 2018

Osseointegrated Percutaneous Prosthetic System for the Treatment of Patients With Transfemoral Amputation: A Prospective Five-year Follow-up of Patient-reported Outcomes and Complications.

J Am Acad Orthop Surg 2018 Dec 13. Epub 2018 Dec 13.

From the Centre for Advanced Reconstruction of Extremities (C.A.R.E.), Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Brånemark, Dr. Hagberg, Mrs. Kulbacka-Ortiz, and Dr. Berlin), International Centre for Osseointegration Research, Education and Surgery (iCORES), Department of Orthopaedics, University of California, San Francisco, CA (Dr. Brånemark), and the Sahlgrenska University Hospital, Department of Orthopaedics, Institute for Clinical Sciences, The Sahlgrenska Academy, University of Gothenburg, Mölndal, Sweden (Dr. Rydevik).

Introduction: Direct skeletal attachment of prostheses has previously been shown to improve patient-reported outcome (PRO) measures of individuals with transfemoral amputation (TFA) at 2-year follow-up. This prospective study reports the outcomes at 5-year follow-up.

Methods: A total of 51 patients (55 legs) with TFA were included in a prospective study. Read More

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December 2018

Nocturnal ventricular repolarization lability predicts cardiovascular mortality in the Sleep Heart Health Study.

Am J Physiol Heart Circ Physiol 2018 Dec 14. Epub 2018 Dec 14.

Institut für Biomedizinische Technik, TU Dresden.

Background-The objective of this study was to quantify repolarization lability and its association with sex, sleep stage and cardiovascular mortality. Methods-We analyzed polysomnographic recordings of 2,263 participants enrolled in the Sleep heart health study (SHHS-2). Beat-to-beat QT interval variability (QTV) was quantified for consecutive epochs of 5 minutes according to the dominant sleep stage (AWAKE, NREM2, NREM3, REM). Read More

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December 2018

Motion fluency and object preference: Robust perceptual but fragile memory effects.

J Exp Psychol Learn Mem Cogn 2018 Dec 13. Epub 2018 Dec 13.

Department of Psychology.

In 8 experiments, we investigated motion fluency effects on object preference. In each experiment, distinct objects were repeatedly seen moving either fluently (with a smooth and predictable motion) or disfluently (with sudden and unpredictable direction changes) in a task where participants were required to respond to occasional brief changes in object appearance. Results show that (a) fluent objects are preferred over disfluent objects when ratings follow a moving presentation, (b) there is some evidence that object-motion associations can be learned with repeated exposures, (c) sufficiently potent motions can yield preference for fluent objects after a single viewing, and (d) learned associations do not transfer to situations where ratings follow a stationary presentation, even after deep levels of encoding. Read More

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December 2018

[The surgical management of upper parapharyngeal regions].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Dec;32(23):1804-1809

Department of Otorhinolaryngology, the First Affiliated Hospital, Bengbu Medical College, Bengbu, 233004, China.

To find proper the surgical approval and evaluate clinical efficacy to treat the tumor of upper parapharyngeal space involving the base of skull and intracranial skull. The data of 9 cases from June 2013 and June 2018 were analyzed retrospectively including schwannoma in 6 cases, pleomorphic adenoma in 2 cases and hemangioma in 1 case. All cases received preoperative high resolution CT and MRI, some cases also did the DSA examination. Read More

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December 2018
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Sparsity-based photoacoustic image reconstruction with a linear array transducer and direct measurement of the forward model.

J Biomed Opt 2018 Dec;24(3):1-9

Dartmouth College, Thayer School of Engineering, Hanover, New Hampshire, United States.

Photoacoustic (PA) imaging is an emerging imaging technique for many clinical applications. One of the challenges posed by clinical translation is that imaging systems often rely on a finite-aperture transducer rather than a full tomography system. This results in imaging artifacts arising from an underdetermined reconstruction of the initial pressure distribution (IPD). Read More

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December 2018

Models and machines: How deep learning will take clinical pharmacology to the next level.

CPT Pharmacometrics Syst Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Roche Pharmaceutical Research & Early Development, Roche Innovation Center Basel, Switzerland.

Recent advances in machine learning (ML) have led to enthusiasm about its use throughout the biopharmaceutical industry. ML methods can be applied to a wide range of problems and have the potential to revolutionize aspects of drug development. The incorporation of ML in modeling and simulation (M+S) has been eagerly anticipated and in this perspective we highlight examples where ML and M+S approaches can be integrated as complementary parts of a clinical pharmacology workflow. Read More

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December 2018