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J Investig Med 2022 Jun 27. Epub 2022 Jun 27.

Department of Otorhinolaryngology, Yildirim Beyazit University, Ankara, Turkey.

This study aimed to analyze laboratory and radiological imaging results in the prediction of treatment strategy in patients with deep neck infections. Eighty-three patients (55 (66.3%) men, mean age: 38. Read More

BMJ Case Rep 2022 Jun 20;15(6). Epub 2022 Jun 20.

Dentistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Ludwig's angina is a rapidly spreading, potentially fatal infection of deep fascial spaces of the neck leading to airway oedema and death. This, in recent times when associated with COVID-19 infection, possess treatment challenges making the patient susceptible to opportunistic infections with reduced healing potential. Owing to the multifactorial aetiology in our case and addressing them at the earliest, it is important to achieve favourable outcomes. Read More

Biomed Res Int 2022 6;2022:5456616. Epub 2022 Jun 6.

Department of Orthopaedic Surgery, The 3rd Hospital of Hebei Medical University, Shijiazhuang, 050051 Hebei, China.

Background: Surgical site infection (SSI) was a formidable challenge for surgical management of femoral neck fractures; however, there was a lack of studies with comprehensive variables. We conducted this study to investigate the incidence and risk factors of SSI in elderly patients with femoral neck fractures.

Methods: This was a retrospective study of patients who presented with femoral neck fractures and underwent surgery in our institution between January 2016 and April 2020. Read More

J Immunother Cancer 2022 Jun;10(6)

Department of Head and Neck-Endocrine Oncology, H Lee Moffitt Cancer Center and Research Center Inc, Tampa, Florida, USA

Background: T cell receptor (TCR) signaling profile is a fundamental property that underpins both adaptive and innate immunity in the host. Despite its potential clinical relevance, the TCR repertoire in peripheral blood has not been thoroughly explored for its value as an immunotherapy efficacy biomarker in head and neck squamous cell carcinoma (HNSCC). The purpose of the present study is to characterize and compare the TCR repertoire in peripheral blood mononuclear cells (PBMC) from patients with HNSCC treated with the combination of cetuximab and nivolumab. Read More

J Clin Med 2022 May 12;11(10). Epub 2022 May 12.

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-111 Szczecin, Poland.

The treatment of oral and maxillofacial infections is based on a recognized algorithm that may require modification under the influence of various local and systemic factors. The aim of this study was to present a comprehensive and microbiological profile of oral and maxillofacial infections, and explore possible correlations between the course of an infection and selected systemic factors based on the medical records of 329 patients affected by the disease. We identified most common clinical, demographic, bacterial, and laboratory parameters specific for these infections. Read More

Children (Basel) 2022 Apr 26;9(5). Epub 2022 Apr 26.

Università degli Studi di Milano, 20122 Milan, Italy.

Deep neck infections (DNIs) include all the infections sited in the potential spaces and fascial planes of the neck within the limits of the deep layer of the cervical fascia. Parapharyngeal and retropharyngeal infections leading to parapharyngeal abscess (PPA) and retropharyngeal abscess (RPA) are the most common. DNIs remain an important health problem, especially in children. Read More

J Stomatol Oral Maxillofac Surg 2022 May 14. Epub 2022 May 14.

Clinical Center of Vojvodina, Clinic for Maxillofacial and Oral Surgery, Novi Sad, Serbia; University of Novi Sad, Faculty of medicine, Department for dentistry and maxillofacial surgery, Novi Sad, Serbia.

Objectives: Descending necrotizing mediastinitis (DNM) is the most serious complication of maxillofacial infections followed with high mortality. The objective of this retrospective study was to evaluate possible prognostic clinical factors for survival of patients with DNM based on single center clinical data.

Methods: The study enrolled patients admitted to the Emergency Center of Vojvodina with the diagnosis of DNM either as the primary diagnosis or with discharged diagnosis after surgical treatment during 11-years period. Read More

Am J Case Rep 2022 May 12;23:e936034. Epub 2022 May 12.

Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan.

BACKGROUND COVID-19 is treated using antiviral and immunosuppressive drugs. Therefore, patients treated for COVID-19 may have an increased risk of secondary infection and a masked inflammatory response. We present a case of a deep neck abscess caused by pyogenic sternoclavicular arthritis during treatment for COVID-19. Read More

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2022 Apr;57(4):405-412

Otolaryngol Pol 2021 Oct;76(2):42-45

Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Ostrava, Czech Republic.

<b>Aim:</b> The aim of this study was to compare the odontogenic and tonsillar origins of deep neck infection (DNI) as a negative prognostic factor for developing complications. </br></br> <b>Methods:</b> This was a retrospective study of 544 patients with tonsillar and odontogenic origins of DNI treated between 2006 and 2015 at 6 ENT Departments and Departments of Oral and Maxillofacial Surgery. Complications from DNI (descending mediastinitis, sepsis, thrombosis of the internal jugular vein, pneumonia, and pleuritis) were evaluated in both groups and compared. Read More

Tumour Virus Res 2022 Jun 20;13:200237. Epub 2022 Apr 20.

Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA; Department of Cancer Prevention & Control, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA; Department of Epidemiology & Population Health, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:

Background: HIV has been shown to increase the likelihood of oral HPV infection. In this study, we evaluated the risk of oral HPV in HIV infected patients compared with HIV-negative controls.

Methods: 101 healthy adult volunteers (HIV-) and 245 adults living with HIV infection (HIV+) were recruited from 5 academic medical centers. Read More

Diagnostics (Basel) 2022 Apr 9;12(4). Epub 2022 Apr 9.

School of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

Deep neck infection (DNI) is associated with morbidity and mortality. Surgical incision and drainage (I&D) of DNI abscesses are essential. Refractory abscesses require repeat I&D. Read More

Tomography 2022 04 1;8(2):920-932. Epub 2022 Apr 1.

Section of Otorhinolaryngology, Department of Neurosciences, University of Padova, Via Giustiniani 2, 35128 Padova, Italy.

Bezold's abscess is a deep neck abscess related to otomastoiditis. Due to the insidious clinical presentation, diagnosis can be extremely challenging, leading to delays in treatment and possible life-threatening complications. The literature currently provides a fragmented picture, presenting only single or small number of cases. Read More

Ned Tijdschr Tandheelkd 2022 Apr;129(4):175-183

Treatment of odontogenic infections, such as drainage of submucosal abscesses, should be carried out by the dental practitioner. However, when an odontogenic infection deteriorates into a deep neck abscess, treatment should be carried out by the oral maxillofacial surgeon. Based on two cases, this article describes the clinical presentation, course, and necessary treatment of a deep neck abscess. Read More

Am J Otolaryngol 2022 May-Jun;43(3):103463. Epub 2022 Apr 6.

School of Medicine, Chang Gung University, Taoyuan, Taiwan; Department of Otorhinolaryngology & Head and Neck Surgery, Chang Gung Memorial Hospital, Linkou, Taiwan. Electronic address:

Background: Deep neck infection (DNI) is a life-threatening condition of the deep neck spaces with potential to obstruct the airway. Aspiration pneumonia (AP), which results from aspiration of colonized oropharyngeal or upper gastrointestinal contents, is a respiratory infection that affects the lungs, wherein the air sacs are filled with purulent fluid. The cooccurrence of these two diseases can cause severe damage to the respiratory system, leading to morbidity and mortality. Read More

SAGE Open Med Case Rep 2022 4;10:2050313X221089119. Epub 2022 Apr 4.

Department of Otolaryngology-Head and Neck Surgery, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada.

Pharyngeal abscesses require urgent management as they have the propensity to cause severe and life-threatening complications. The introduction of antibiotics has led to a dramatic decline in the incidence of these infections. Regardless, abscess formation continues to be observed in the peritonsillar, parapharyngeal, and retropharyngeal spaces. Read More

Intensive Crit Care Nurs 2022 Aug 23;71:103251. Epub 2022 Mar 23.

Department of ENT and Head and Neck Surgery, Angers University Hospital, 4 rue Larrey, 49933 ANGERS Cedex, France; MitoLab team, MitoVasc Institute, CNRS UMR6015, INSERM U1083, 49933 ANGERS Cedex 09, France.

We report the case of a 59-year-old, obese woman who underwent prolonged prone position during the medical management of an acute respiratory distress syndrome induced by SARS-CoV-2 infection, complicated by a masseter muscle pressure injury. Such side effect may be underestimate in intensive care units and should be prevent by prophylactic dressings on facial weight-bearing sites. The understanding of facial deep tissue injury is essential to guide clinical detection and management of such a complication in COVID-19 patients. Read More

Cureus 2022 Feb 21;14(2):e22438. Epub 2022 Feb 21.

Department of Surgery, Division of Trauma and Acute Care Surgery, University of South Florida Morsani College of Medicine/Lehigh Valley Health Network Campus, Bethlehem, USA.

Necrotizing fasciitis is a life-threatening infection that can be rapidly fatal. Early identification and emergent surgical management are essential to minimize morbidity and mortality. This case report describes a 25-year-old male who presented to the emergency department with a three-day history of worsening left lower dental infection and new-onset neck pain and swelling. Read More

J Healthc Eng 2022 24;2022:1540774. Epub 2022 Mar 24.

Department of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing 100853, China.

Objective: Hidradenitis suppurativa (HS) is a rare autosomal dominant condition characterized by inflamed nodules, cysts, deep abscesses, draining sinuses in the axillae, inguinal, and anogenital regions. Mutations in the NCSTN gene have been perceived to be responsible for the major underlying changes in the disorder. The purpose of this study is to identify a novel gene mutation in a Chinese family with HS. Read More

Head Neck Pathol 2022 Mar 25. Epub 2022 Mar 25.

Oral Pathology and Medicine Master, Health Care Department, Autonomous Metropolitan University, Calzada del Hueso 1100, col. Villa Quietud, 04960, Mexico City, Mexico.

Oral secondary syphilis may mimic various infectious, neoplastic, or immune-mediated processes; hence, its diagnosis may represent a challenge. Early diagnosis of syphilis, a disease that has increased in recent decades, is essential for adequate management, particularly in people living with HIV (PLWH). This study aimed to comprehensively characterize oral secondary syphilis in a group of 47 PLWH. Read More

BMC Infect Dis 2022 Mar 23;22(1):280. Epub 2022 Mar 23.

Otorhinolaryngology Hospital, First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan 2nd Road, Guangzhou, Guangdong, People's Republic of China.

Background: Deep neck space abscess (DNSA) is a serious infection in the head and neck. Antibiotic therapy is an important treatment in patients with DNSA. However, the results of bacterial culture need at least 48 h, and the positive rate is only 30-50%, indicating that the use of empiric antibiotic treatment for most patients with DNSA should at least 48 h or even throughout the whole course of treatment. Read More

Tomography 2022 03 7;8(2):718-729. Epub 2022 Mar 7.

Department of Otolaryngology-Head and Neck Surgery Tri-Service General Hospital, National Defense Medical Center No. 325, Sec. 2, Cheng-Gong Road, Neihu District, Taipei 114, Taiwan.

Background: The traditional Lund-Mackay score (TLMs) is unable to subgrade the volume of inflammatory disease. We aimed to propose an effective modification and calculated the volume-based modified LM score (VMLMs), which should correlate more strongly with clinical symptoms than the TLMs.

Methods: Semi-supervised learning with pseudo-labels used for self-training was adopted to train our convolutional neural networks, with the algorithm including a combination of MobileNet, SENet, and ResNet. Read More

PLoS One 2022 25;17(2):e0263125. Epub 2022 Feb 25.

Medical AI Research Center, Samsung Medical Center, Seoul, Republic of Korea.

Background: This study aims to develop artificial intelligence (AI) system to automatically classify patients with maxillary sinus fungal ball (MFB), chronic rhinosinusitis (CRS), and healthy controls (HCs).

Methods: We collected 512 coronal image sets from ostiomeatal unit computed tomography (OMU CT) performed on subjects who visited a single tertiary hospital. These data included 254 MFB, 128 CRS, and 130 HC subjects and were used for training the proposed AI system. Read More

J Bone Joint Surg Am 2022 05 23;104(9):780-789. Epub 2022 Feb 23.

Department of Orthopaedic Surgery, Washington University School of Medicine, St Louis, Missouri.

Background: Residual Legg-Calvé-Perthes (LCP) deformities represent one of the most challenging disorders in hip reconstructive surgery. In complex cases, both instability (acetabular dysplasia) and multifocal femoroacetabular impingement (FAI) (proximal femoral deformities) require correction. We assessed intermediate-term patient-reported outcome measures, radiographic correction, complications, and survivorship for combined surgical dislocation (SD) and periacetabular osteotomy (PAO) for the treatment of complex LCP deformities. Read More

Acta Otorrinolaringol Esp (Engl Ed) 2022 Jan-Feb;73(1):4-10

Sección de Cirugía de Cabeza y Cuello, Hospital Prof. A. Posadas, El Palomar, Argentina.

Introduction: The most common cause of deep neck infections is dental infection. They are diagnosed with physical examination, imaging studies, ultrasound, or computed tomography. Surgical drainage of collections should always be performed early in a classical or percutaneous way, depending on the case. Read More

Neuroradiol J 2022 Feb 21:19714009211059122. Epub 2022 Feb 21.

Department of Diagnostic Radiology, 66984American University of Beirut, Lebanon.

Non-traumatic head and neck emergencies include several disease processes such as infectious, inflammatory, and malignant. Infections are among the most common pathological processes that affect the head and neck, and are particularly important due to their acute, severe, and potentially life-threatening nature. Radiologists need to be well acquainted with these entities because any delay or misdiagnosis can lead to significant morbidity and mortality. Read More

Pediatr Radiol 2022 05 20;52(6):1158-1166. Epub 2022 Feb 20.

Diagnostic Radiology, University of Turku, Kiinamyllynkatu 4-8, 20520, Turku, Finland.

Background: Differences in the functioning of the immune system and the anatomical proportions of the neck between children and adults lead to different manifestations of deep neck infections. Magnetic resonance imaging (MRI) may serve as an alternative to computed tomography (CT) as the primary imaging modality.

Objective: To study characteristic MRI findings and the diagnostic accuracy of MRI in pediatric deep neck infections. Read More

Acta Otolaryngol 2022 Feb 3;142(2):202-205. Epub 2022 Feb 3.

Department of Otorhinolaryngology, Kindai University Faculty of Medicine, Osaka, Japan.

Malignant neoplasms (MNs) in the head and neck are occasionally hidden in deep neck infections (DNIs) that require emergency treatment, which potentially leads to delayed diagnosis of MNs. This study aimed to identify predictive factors that can prevent delays in diagnosing MNs in patients with DNIs. We retrospectively analysed data from 83 patients admitted to our hospital who were diagnosed with DNIs. Read More

Diagnostics (Basel) 2021 Dec 23;12(1). Epub 2021 Dec 23.

School of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

Deep neck infection (DNI) is a serious disease of deep neck spaces that can lead to morbidities and mortality. Acute epiglottitis (AE) is a severe infection of the epiglottis, which can lead to airway obstruction. However, there have been no studies of risk factors in patients with concurrent DNI and AE. Read More

Vestn Otorinolaringol 2021 ;86(6):62-68

Morozovskaya Children's City Clinical Hospital, Moscow, Russia.

Parapharyngeal and retropharyngeal abscesses (PPA) in children are a rare pathology, for the diagnosis of which it is necessary to use additional instrumental examination methods. The tactics of treating patients remains a subject of discussion.

Objective: To analyze the features of the clinic, diagnosis and treatment of PPA in children. Read More