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A giant sacrococcygeal teratoma in adult female: A case report.

Int J Surg Case Rep 2018 Nov 22;54:47-50. Epub 2018 Nov 22.

Department of General Surgery, King Abdulla University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box (3030), Irbid, 22110, Jordan. Electronic address:

Introduction: Sacrococcygealteratoma is very rare in adults with only few cases reported in literature. It is a slow growing benign cystic tumor with 1-2% chance for malignant transformation and may attain a huge size causing pressure effect on pelvic and intra-abdominal organs. When grows caudally, it causes discomfort, skin excoriation and cosmetic disfigurement. Read More

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November 2018
3 Reads

Highly effective and safe intermediate based on deep eutectic medium for carrier less-three phase hollow fiber microextraction of antiarrhythmic agents in complex matrices.

J Chromatogr B Analyt Technol Biomed Life Sci 2018 Nov 7;1104:196-204. Epub 2018 Nov 7.

Department of Chemistry, Semnan University, Semnan 35195-363, Iran.

For the first time, three phase hollow fiber liquid phase microextraction using an influential, and green middle phase comprised a new relatively-hydrophobic deep eutectic solvent (three-phase HF-LPME-DES) was developed for trace analyses of antiarrhythmic drugs in biological and environmental samples. The extraction solvent was easily synthesized by mixing the green and cheap raw materials, namely choline chloride and 1-phenylethanol (ChCl: Ph-ETOH), in the ambient temperature. Good compatibility to pores of hollow-fiber, high ability for extraction of ionizable organic compounds with no need to any carrier agents, and easy availability in the laboratory environment turned this new proposed deep eutectic intermediate to a worthy generation of the supported liquid membrane (SLM). Read More

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November 2018
2 Reads

Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins.

Cell Signal 2018 Dec 3. Epub 2018 Dec 3.

Division of Cell Matrix Biology & Regenerative Medicine, UK. Electronic address:

Photodamage in chronically sun-exposed skin manifests clinically as deep wrinkles and histologically as extensive remodelling of the dermal extracellular matrix (ECM) and in particular, the elastic fibre system. We have shown previously that loss of fibrillin microfibrils, a key elastic fibre component, is a hallmark of early photodamage and that these ECM assemblies are susceptible in vitro to physiologically attainable doses of ultraviolet radiation (UVR). Here, we test the hypotheses that UVR-mediated photo-oxidation is the primary driver of fibrillin microfibril and fibronectin degradation and that prior UVR exposure will enhance the subsequent proteolytic activity of UVR-upregulated matrix metalloproteinases (MMPs). Read More

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December 2018
2 Reads

An Interactive and Low-Cost Full Body Rehabilitation Framework Based on 3D Immersive Serious Games.

J Biomed Inform 2018 Dec 3. Epub 2018 Dec 3.

Department of Computer Science Sapienza University of Rome, Via Salaria 113, 00198, Rome, Italy. Electronic address:

Strokes, surgeries, or degenerative diseases can impair motor abilities and balance. Long-term rehabilitation is often the only way to recover, as completely as possible, these lost skills. To be effective, this type of rehabilitation should follow three main rules. Read More

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December 2018
1 Read

Extracellular polymeric substances (EPS) producing and oil degrading bacteria isolated from the northern Gulf of Mexico.

PLoS One 2018 6;13(12):e0208406. Epub 2018 Dec 6.

Department of Marine Biology, Texas A&M University at Galveston, Galveston, Texas, United States of America.

Sinking marine oil snow was found to be a major mechanism in the transport of spilled oil from the surface to the deep sea following the Deepwater Horizon (DwH) oil spill. Marine snow formation is primarily facilitated by extracellular polymeric substances (EPS), which are mainly composed of proteins and carbohydrates secreted by microorganisms. While numerous bacteria have been identified to degrade oil, there is a paucity of knowledge on bacteria that produce EPS in response to oil and Corexit exposure in the northern Gulf of Mexico (nGoM). Read More

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December 2018

Bayesian adaptive dual control of deep brain stimulation in a computational model of Parkinson's disease.

PLoS Comput Biol 2018 Dec 6;14(12):e1006606. Epub 2018 Dec 6.

Department of Biomedical Engineering, University of Minnesota, Minneapolis, Minnesota, United States of America.

In this paper, we present a novel Bayesian adaptive dual controller (ADC) for autonomously programming deep brain stimulation devices. We evaluated the Bayesian ADC's performance in the context of reducing beta power in a computational model of Parkinson's disease, in which it was tasked with finding the set of stimulation parameters which optimally reduced beta power as fast as possible. Here, the Bayesian ADC has dual goals: (a) to minimize beta power by exploiting the best parameters found so far, and (b) to explore the space to find better parameters, thus allowing for better control in the future. Read More

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December 2018

Transverse and longitudinal spin-fluctuations in INVAR FeNi.

J Phys Condens Matter 2019 Jan;31(2):025802

ISIS Neutron and Muon Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Didcot, OX11 0QX, United Kingdom.

The presence of spin-fluctuations deep within the ordered state of ferromagnetic [Formula: see text] alloy [Formula: see text] has long been suspected but seldom directly observed. Inhomogeneities of one type or another have been cited as important in stabilizing [Formula: see text] behaviour-either longitudinal spin-fluctuations associated with the [Formula: see text]-state (local environment) model or transverse magnetisation arising from non-collinear spin structures. In this study we employ small-angle neutron scattering with neutron polarization analysis to distinguish between the two possibilities. Read More

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January 2019
2 Reads

Graphene Quantum Dots-Mediated Theranostic Penetrative Delivery of Drug and Photolytics in Deep Tumors by Targeted Biomimetic Nanosponges.

Nano Lett 2018 Dec 6. Epub 2018 Dec 6.

Dual targeted delivery of drugs and energy by nanohybrids can potentially alleviate side effects and improve the unique features required for precision medicine. To realize this aim, however, the hybrids which are often rapidly removal from circulation and piled up tumors periphery near the blood vessels must address the difficulties in low blood half-lives and tumor penetration. In this study, a sponge-inspired carbon composites-supported red blood cell (RBC) membrane that doubles as a stealth agent and photolytic carrier that transports tumor-penetrative agents (graphene quantum dots and docetaxel (GQD-D)) and heat with irradiation was developed. Read More

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December 2018

Medial elbow anatomy: A paradigm shift for UCL injury prevention and management.

Clin Anat 2018 Dec 6. Epub 2018 Dec 6.

Department of Clinical Anatomy, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Introduction: To improve the management outcomes and diagnostic accuracy of the ulnar collateral ligament (UCL) injury, the anatomy of the medial side of the elbow joint is necessary to be understood in terms of the periarticular surroundings rather than the specific ligaments. The aim of this study was to anatomically clarify the medial side of the elbow joint in terms of the tendinous structures and joint capsule.

Materials And Methods: We conducted a descriptive anatomical study of 23 embalmed cadaveric elbows. Read More

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December 2018

Resolving Deep Nodes in an Ancient Radiation of Neotropical Fishes in the Presence of Conflicting Signals from Incomplete Lineage Sorting.

Syst Biol 2018 Dec 6. Epub 2018 Dec 6.

Museum of Natural Science, Department of Biological Sciences, Louisiana State University, Baton Rouge, Louisiana, USA.

Resolving patterns of ancient and rapid diversifications is one of the most challenging tasks in evolutionary biology. These difficulties arise from confusing phylogenetic signals that are associated with the interplay of incomplete lineage sorting and homoplasy. Phylogenomic analyses of hundreds, or even thousands, of loci offer the potential to resolve such contentious relationships. Read More

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December 2018

Capsule Network for Protein Post-Translational Modification Site Prediction.

Bioinformatics 2018 Dec 6. Epub 2018 Dec 6.

Department of Electrical Engineering and Computer Science, and Christopher S. Bond Life Sciences Center, University of Missouri, Columbia, USA.

Motivation: Computational methods for protein post-translational modification (PTM) site prediction provide a useful approach for studying protein functions. The prediction accuracy of the existing methods has significant room for improvement. A recent deep-learning architecture, Capsule Network (CapsNet), which can characterize the internal hierarchical representation of input data, presents a great opportunity to solve this problem, especially using small training data. Read More

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December 2018

Excellent benzocoumarin-based ratiometric two-photon fluorescent probe for HO detection.

Phys Chem Chem Phys 2018 Dec 6. Epub 2018 Dec 6.

Laboratory of Theoretical and Computational Chemistry, Institute of Theoretical Chemistry, Jilin University, Liutiao Road 2#, Changchun 130061, China.

The level of hydrogen peroxide (H2O2) plays an essential role in regulating biological processes. The in vivo or in vitro detection of H2O2 in deep tissues by utilizing two-photon (TP) fluorescent probes can significantly alleviate the detection damage inflicted onto living organisms as well as facilitate high-resolution imaging when compared with one-photon (OP) fluorescent probes. However, few TP fluorescent probes possess both high fluorescence efficiency and easily distinguishable spectra for measuring H2O2. Read More

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December 2018

Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists.

Elife 2018 Dec 6;7. Epub 2018 Dec 6.

Department of Developmental Genetics, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

Pathways modulating glucose homeostasis independently of insulin would open new avenues to combat insulin resistance and diabetes. Here, we report the establishment, characterization and use of a vertebrate 'insulin-free' model to identify insulin-independent modulators of glucose metabolism. knockout zebrafish recapitulate core characteristics of diabetes and survive only up to larval stages. Read More

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December 2018

Effect of preservation methods on tensile properties of human femur-ACL-tibial complex (FATC) - a cadaveric study on male subjects.

Acta Bioeng Biomech 2018 ;20(4):31-42

Centre for Biomedical Engineering, Indian Institute of Technology (IIT) Delhi, New Delhi, India.

Purpose: Deep freezing and storing in formalin are some of the common techniques of human tissue preservation. However, the preservation modes affect the biomechanical properties of the tissues. In this work, the effects of the above-stated preservation tech- niques are compared with that of fresh cadaveric samples. Read More

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January 2018

2D and 3D real-time passive cavitation imaging of pulsed cavitation ultrasound therapy in moving tissues.

Phys Med Biol 2018 Dec 6;63(23):235028. Epub 2018 Dec 6.

Institut Langevin, ESPCI ParisTech, CNRS UMR 7587, INSERM U979, Paris 7, 17 rue Moreau, 75012 Paris, France. Cardiawave SA, 29 rue du Faubourg Saint Jacques, 75014, Paris, France.

Pulsed cavitation ultrasound therapy (PCUT) is an effective non-invasive therapeutic approach in various medical indications that relies on the mechanical effects generated by cavitation bubbles. Even though limited by the poor contrast, conventional ultrasound B-Mode imaging has been widely used for the guidance and monitoring of the therapeutic procedure, allowing the visualization of the cavitation bubble cloud. However, the visualization of the bubble cloud is often limited in deep organs such as the liver and the heart and remains moreover completely subjective for the operator. Read More

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December 2018
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Graphene interdigital electrodes for improving sensitivity in Ga2O3:Zn deep-ultraviolet photoconductive detector.

ACS Appl Mater Interfaces 2018 Dec 6. Epub 2018 Dec 6.

Graphene (Gr) has been widely used as a transparent electrode material for photodetectors due to its high conductivity and high transmittance, in recent years. However, the currently low-efficiency manipulation of Gr has hindered the arraying and practical use of such detectors. We invented a multi-step method of accurately tailoring graphene into interdigital electrodes, for fabricating a sensitive, stable deep-ultraviolet photodetector based on Zn-doped Ga2O3 films. Read More

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December 2018

A new approach to lower eyelid-cheek junction rejuvenation.

J Cosmet Dermatol 2018 Dec 5. Epub 2018 Dec 5.

Beijing Lomeye Cosmetic Surgery Clinic, Beijing, China.

Background: Anti-aging in lower eyelid-cheek junction area has always been the upmost widely sought of cosmetic surgery. Removal of orbital fat from inside or outside, removal of part of the skin or even the orbicularis muscle, superficial pull and deep fill and a series of surgical procedures like these have been or are becoming the mainstream of clinical practice. However, aging involves a variety of tissues and causes, which is a dynamic and continuous process. Read More

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December 2018
1 Read

Deep integrative analysis of microRNA-mRNA regulatory networks for biomarker and target discovery in chondrosarcoma.

J Cell Biochem 2018 Dec 5. Epub 2018 Dec 5.

Department of Joint Surgery, The Affiliated Hospital of Jining Medical University, Shandong, China.

Chondrosarcoma (CHS) is a common malignant bone sarcoma and its occurrence increases with age. microRNAs (miRNAs) are a class of noncoding RNAs that participate in various biological processes and disease pathogenesis by targeting functional messenger RNA (mRNA). However, the modulation of miRNAs in CHS remains largely unknown. Read More

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December 2018
1 Read

Deep-Learning Convolutional Neural Network: Inner and Outer Bladder Wall Segmentation in CT Urography.

Med Phys 2018 Dec 5. Epub 2018 Dec 5.

Department of Radiology, The University of Michigan, Ann Arbor, Michigan, 48109-0904.

Purpose: We are developing a computerized segmentation tool for the inner and outer bladder wall as a part of an image analysis pipeline for CT urography (CTU).

Materials And Methods: A data set of 172 CTU cases was collected retrospectively with IRB approval. The data set was randomly split into two independent sets of training (81 cases) and testing (92 cases) which were manually outlined for both the inner and outer wall. Read More

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December 2018

Characteristic "neck collar" injuries in Australian sea lions (Neophoca cinerea) caused by marine debris.

Forensic Sci Med Pathol 2018 Dec 5. Epub 2018 Dec 5.

Australian Marine Wildlife Research and Rescue Organization (AMWRRO), Adelaide, South Australia, 5000, Australia.

An adult male Australian sea lion (Neophoca cinerea) presented with a deep, almost circumferential, incised wound around the neck caused by a noose formed by a single strand of green nylon rope. The wound extended 4-5 cm deeply through the skin and blubber into skeletal muscle, predominantly on the dorsal surface and left side, but had not involved the airway or major vessels. The edges of the wound were sharply incised and oozing blood with a granulating infected base. Read More

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December 2018
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An original procedure for orbitonasal cutaneous infiltrative tumor repair, using combined forehead and melolabial propeller flaps.

Eur Arch Otorhinolaryngol 2018 Dec 5. Epub 2018 Dec 5.

Institut Universitaire de la Face et du Cou, Centre Hospitalier Universitaire de NICE, 31 Avenue de Valombrose, 06100, Nice, Alpes-Maritimes, France.

Introduction: Resections of cutaneous tumors in the medial orbitonasal region can be transfixing. Repairs using a single local flap run the risk of failure and that of secondary sinonasal fistula, especially in cases of surgery on a radiated field. We propose an original and reliable repair procedure using two pedicled regional flaps vascularized by two distinct arterial systems clinched together to reconstruct the mucosal and cutaneous planes. Read More

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December 2018

Colo-Pro: a pilot randomised controlled trial to compare standard bolus-dosed cefuroxime prophylaxis to bolus-continuous infusion-dosed cefuroxime prophylaxis for the prevention of infections after colorectal surgery.

Eur J Clin Microbiol Infect Dis 2018 Dec 5. Epub 2018 Dec 5.

Old Medical School, Leeds General Infirmary, Leeds Teaching Hospitals NHS Trust, Leeds, LS1 3EX, UK.

Standard bolus-dosed antibiotic prophylaxis may not inhibit growth of antibiotic resistant colonic bacteria, a cause of SSIs after colorectal surgery. An alternative strategy is continuous administration of antibiotic throughout surgery, maintaining concentrations of antibiotics that inhibit growth of resistant bacteria. This study is a pilot comparing bolus-continuous infusion with bolus-dosed cefuroxime prophylaxis in colorectal surgery. Read More

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December 2018

Automatic detection of perforator vessels using infrared thermography in reconstructive surgery.

Int J Comput Assist Radiol Surg 2018 Dec 5. Epub 2018 Dec 5.

Innovation Center Computer Assisted Surgery, University Leipzig, Semmelweisstr. 14, 04103, Leipzig, Germany.

Purpose: Knowing the location of the blood vessels supplying the skin and subcutaneous tissue is a requirement during the planning of tissue transfer in reconstructive surgery. Commonly used imaging techniques such as computed tomography angiography and indocyanine green angiography expose the patient to radiation or a contrast agent, respectively. Infrared thermal imaging was evaluated with success as a non-invasive alternative. Read More

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December 2018
3 Reads

Surveillance Ultrasound in the Neuro Intensive Care Unit: Time to Deep Vein Thrombosis Diagnosis.

Neurocrit Care 2018 Dec 5. Epub 2018 Dec 5.

University Health System, San Antonio, TX, USA.

Background/objectives: Deep vein thrombosis (DVT) and pulmonary embolism (PE) are complications of hospitalization leading to increased morbidity and mortality. Routine surveillance ultrasound has become common practice in some intensive care units (ICU) to detect DVT early and initiate anticoagulation, preventing complications. However, initiating anticoagulants for asymptomatic DVT treatment may increase risk of hemorrhage. Read More

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December 2018

Risk factors for potential pulmonary embolism in the patients with deep venous thrombosis: a retrospective study.

Eur J Trauma Emerg Surg 2018 Dec 5. Epub 2018 Dec 5.

Digital Subtraction Room, Tianjin Hospital, No. 406, south liberation road, Hexi district, Tianjin, 300211, China.

Introduction: The risk factors for the detachment of big thrombi from the vessel wall in patients with deep venous thrombosis (DVT) are still not clear, which are potential risks for pulmonary embolism (PE). This study was aimed to identify the risk factors for big thrombi detaching from the vessel wall in the patients with lower extremity DVT and to identify the role of the lower limb immobilization.

Methods: We retrospectively reviewed the patients whose inferior vena cava (IVC) filter were removed in our hospital. Read More

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December 2018
1 Read

Microsurgical reconstruction with vascularized fibula and massive bone allograft for bone tumors.

Eur J Orthop Surg Traumatol 2018 Dec 5. Epub 2018 Dec 5.

Department of Orthopaedic Surgery, IRCCS Istituto Ortopedico Rizzoli, via Pupilli n1, 40136, Bologna, Italy.

Introduction: Combining massive bone allograft and vascularized fibula in intercalary reconstruction following resection of bone tumors represents a complex reconstructive procedure that requires specialists in microvascular surgery as well as orthopedic surgery. The purpose of our study was to examine the outcomes using this surgical technique in patients with bone tumors in terms of oncologic results, complications related to surgery, Musculoskeletal Tumor Society (MSTS) scores and duration of surgery.

Materials And Methods: We analyzed 81 patients with femoral or tibial sarcomas who underwent intercalary resection and microsurgical reconstruction with massive bone allograft and vascularized fibula. Read More

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December 2018

High-performance solar-blind SnO nanowire photodetectors assembled using optical tweezers.

Nanoscale 2018 Dec 6. Epub 2018 Dec 6.

Hunan Key Laboratory for Super Microstructure and Ultrafast Process, School of Physics and Electronics, Central South University, Changsha, Hunan 410083, P. R. China. and Department of Physics and Astronomy, University of Rochester, Rochester, NY 14627, USA.

One-dimensional semiconducting SnO2 nanowires with wide bandgaps are promising candidates to build many important optoelectronic devices. Because building these devices involves the assembly of nanowires into complex structures, manipulation of the active materials needs to be done with high spatial precision. In this paper, an optical tweezer system, comprising a spatial light-modulator, a microscope, and optical elements, is used to individually trap, transfer, and assemble SnO2 nanowires into two-terminal photodetectors in a liquid environment. Read More

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December 2018
1 Read

Prospective pilot study comparing deep sclerectomy outcomes with a long-term and intense corticosteroid treatment versus a standard one.

BMJ Open Ophthalmol 2018 31;3(1):e000165. Epub 2018 Oct 31.

Glaucoma and Neuro-Ophthalmology Department, FISABIO Oftalmologia, Valencia, Spain.

Objective: To compare prospectively intraocular pressure (IOP) results after deep sclerectomy (DS) using a topical short-term corticosteroid treatment (STCT, 1  month) versus a topical long-term and intense corticosteroid treatment (LTCT, 6 months) in a two2  year-follow-up.

Methods: Patients with medically uncontrolled open angle glaucoma were prospectively recruited and underwent a DS.

Results: We operated 45 eyes of 45 patients, 22 in STCT group and 23 in LTCT group. Read More

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October 2018

How Bispectral Index Compares to Spectral Entropy of the EEG and A-line ARX Index in the Same Patient.

Open Med (Wars) 2018 24;13:583-596. Epub 2018 Nov 24.

Department of Anaesthesia and Intensive Care Medicine, Innsbruck Medical University, A-6020 Innsbruck, Anichstrasse 35, Innsbruck Austria.

Background: Bispectral index (BIS) monitoring of depth of anesthesia has pioneered the field for more recent monitoring devices like the A-line ARX Index (AAI) or the state (SE) and response entropy (RE) monitoring devices. Following an observational design the present study aimed to simultaneously compare in the same patient recorded BIS, AAI and entropy values.

Methods: Data from patients (n = 32) undergoing minor gynecological operations were analyzed. Read More

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November 2018

Deep cutaneous infection in a patient recovering from toxic epidermal necrolysis.

Med Mycol Case Rep 2019 Mar 26;23:26-28. Epub 2018 Oct 26.

Brooke Army Medical Center, 3551 Roger Brooke Drive, San Antonio, TX, USA.

Patients with toxic epidermal necrolysis, a condition that causes full thickness epidermal necrosis that affects over 30% of the skin surface and mucosal membranes, often develop comorbid infections throughout the recovery of the disease [1]. While most commonly these are related to a bacterial source, infections due to viral, mycobacterial, and rarely fungal organisms occur. We present a case of a patient who developed a deep cutaneous fungal infection caused by Trichosporon asahii and discuss the management. Read More

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March 2019
2 Reads

Ecology and life history of (Araneae: Tetragnathidae) from Monte Albo (Sardinia, Italy).

Authors:
Enrico Lunghi

PeerJ 2018 29;6:e6049. Epub 2018 Nov 29.

Department of Biogeography, Trier University, Trier, Germany.

The orb-weaver spider Simon 1922 (Araneae: Tetragnathidae) is one of the most common cave predators occurring in the Mediterranean basin. Although the congeneric represented the model species in several studies, our knowledge of is only founded on observations performed on a handful of populations. In this study spiders were studied in caves of Monte Albo (Sardinia, Italy) over a year. Read More

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November 2018

Ice ages and butterflyfishes: Phylogenomics elucidates the ecological and evolutionary history of reef fishes in an endemism hotspot.

Ecol Evol 2018 Nov 23;8(22):10989-11008. Epub 2018 Oct 23.

Red Sea Research Center, Division of Biological and Environmental Science and Engineering King Abdullah University of Science and Technology Thuwal Saudi Arabia.

For tropical marine species, hotspots of endemism occur in peripheral areas furthest from the center of diversity, but the evolutionary processes that lead to their origin remain elusive. We test several hypotheses related to the evolution of peripheral endemics by sequencing ultraconserved element (UCE) loci to produce a genome-scale phylogeny of 47 butterflyfish species (family Chaetodontidae) that includes all shallow water butterflyfish from the coastal waters of the Arabian Peninsula (i.e. Read More

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November 2018

The first complete mitochondrial genome of the Mariana Trench (Asteroidea: Brisingida: Brisingidae) allows insights into the deep-sea adaptive evolution of Brisingida.

Ecol Evol 2018 Nov 31;8(22):10673-10686. Epub 2018 Oct 31.

Institute of Deep-Sea Science and Engineering Chinese Academy of Sciences Sanya China.

Starfish (phylum Echinodermata) are ecologically important and diverse members of marine ecosystems in all of the world's oceans, from the shallow water to the hadal zone. The deep sea is recognized as an extremely harsh environment on earth. In this study, we present the mitochondrial genome sequence of Mariana Trench starfish , and this study is the first to explore in detail the mitochondrial genome of a deep-sea member of the order Brisingida. Read More

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November 2018

Deep sequencing analysis of toad skin glands and partial biochemical characterization of its cutaneous secretion.

J Venom Anim Toxins Incl Trop Dis 2018 29;24:36. Epub 2018 Nov 29.

2Laboratory of genetics - LABGEN, Institute of Genetics and Biochemistry, Campus Umuarama, Federal University of Uberlândia, Avenida Pará, Uberlândia, MG 1720 Brazil.

Background: Animal poisons and venoms are sources of biomolecules naturally selected. toads are widespread in the whole Brazilian territory and they have poison glands and mucous gland. Recently, protein from toads' secretion has gaining attention. Read More

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November 2018
1 Read

Seed Germination Indicates Adaptive Transgenerational Plasticity in a Submerged Macrophyte.

Front Plant Sci 2018 21;9:1592. Epub 2018 Nov 21.

Donghu Experimental Station of Lake Ecosystems, State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciencess, Wuhan, China.

Adaptive transgenerational plasticity is an important evolutionary strategy in plants. We investigated the resource allocation strategy in sexual reproduction and performed an seed germination experiment of to reveal their responses to different water depths. Later, we discussed the biased adaptability to the maternal habitat in this species. Read More

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November 2018

Particle-Attached and Free-Living Archaeal Communities in the Benthic Boundary Layer of the Mariana Trench.

Front Microbiol 2018 21;9:2821. Epub 2018 Nov 21.

State Key Laboratory of Ocean Engineering, Institute of Oceanography, Shanghai Jiao Tong University, Shanghai, China.

The benthic boundary layer (BBL) is the part of the water column that is situated near to the sediment surface, where active oceanic biogeochemical cycling occurs. Archaea play an important role in mediating this cycling, however, their composition and diversity in the BBL remain largely unknown. We investigated the community composition and abundance of both particle-attached (PA) and free-living (FL) archaea in the BBL on the slopes of the Mariana Trench using Illumina sequencing and quantitative PCR (qPCR), at both the DNA and RNA levels. Read More

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November 2018

White Matter Changes Along the Electrode Lead in Patients Treated With Deep Brain Stimulation.

Front Neurol 2018 21;9:983. Epub 2018 Nov 21.

Department of Neurology, Christian-Albrechts University of Kiel, Kiel, Germany.

Deep brain stimulation (DBS) is an established treatment for various movement disorders. There is little data available about the potential damage to brain parenchyma through DBS treatment. The objective of this study was to investigate the occurrence of signal changes on magnetic resonance imaging (MRI) in patients treated with DBS. Read More

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November 2018
1 Read

miRNA expression profiles in Smad4-positive and Smad4-negative SW620 human colon cancer cells detected by next-generation small RNA sequencing.

Cancer Manag Res 2018 8;10:5479-5490. Epub 2018 Nov 8.

Department of General Surgery, Zhongshan Hospital, Xiamen University, Xiamen, Fujian 361004 People's Republic of China,

Background And Aims: SMAD4, as a tumor suppressive gene in human colon cancer, inhibits the metastasis of colon adenocarcinoma cells. However, the molecular mechanisms are unclear. miRNAs play an important role in the pathogenesis and progression of cancer. Read More

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November 2018

A proposed mechanism influencing structural patterns in X-linked retinoschisis and stellate nonhereditary idiopathic foveomacular retinoschisis.

Eye (Lond) 2018 Dec 5. Epub 2018 Dec 5.

Vitreous Retina Macula Consultants of New York, New York, NY, USA.

Objective: To explore the structural differences between X-linked retinoschisis (XLR) and stellate nonhereditary idiopathic foveomacular retinoschisis (SNIFR) using swept-source optical coherence tomography angiography (SS-OCTA).

Methods: A case series of two patients, a 9-year-old male with XLR and a 58-year-old woman with SNIFR were imaged with swept-source optical coherence tomography angiography (SS-OCTA; PLEX Elite 900, Carl Zeiss Meditec, Inc, Dublin, CA). Automated segmentation was manually adjusted to include the areas of retinoschisis within en face flow and structural slabs. Read More

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December 2018

Soft-tissue evidence for homeothermy and crypsis in a Jurassic ichthyosaur.

Nature 2018 Dec 5. Epub 2018 Dec 5.

Department of Geology, Lund University, Lund, Sweden.

Ichthyosaurs are extinct marine reptiles that display a notable external similarity to modern toothed whales. Here we show that this resemblance is more than skin deep. We apply a multidisciplinary experimental approach to characterize the cellular and molecular composition of integumental tissues in an exceptionally preserved specimen of the Early Jurassic ichthyosaur Stenopterygius. Read More

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December 2018

Capture of nebular gases during Earth's accretion is preserved in deep-mantle neon.

Nature 2018 Dec 5. Epub 2018 Dec 5.

Department of Earth and Planetary Sciences, University of California-Davis, Davis, CA, USA.

Evidence for the capture of nebular gases by planetary interiors would place important constraints on models of planet formation. These constraints include accretion timescales, thermal evolution, volatile compositions and planetary redox states. Retention of nebular gases by planetary interiors also constrains the dynamics of outgassing and volatile loss associated with the assembly and ensuing evolution of terrestrial planets. Read More

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December 2018

Deep learning for detecting tumour-infiltrating lymphocytes in testicular germ cell tumours.

J Clin Pathol 2018 Dec 5. Epub 2018 Dec 5.

Nuffield Department of Surgical Sciences and NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK.

Aims: To evaluate if a deep learning algorithm can be trained to identify tumour-infiltrating lymphocytes (TILs) in tissue samples of testicular germ cell tumours and to assess whether the TIL counts correlate with relapse status of the patient.

Methods: TILs were manually annotated in 259 tumour regions from 28 whole-slide images (WSIs) of H&E-stained tissue samples. A deep learning algorithm was trained on half of the regions and tested on the other half. Read More

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December 2018

Management of bacterial skin and skin structure infections with polymicrobial aetiology.

Expert Rev Anti Infect Ther 2018 Dec 6. Epub 2018 Dec 6.

b AORN dei Colli Dept of Infectious Diseases , Naples , Italy .

Introduction: Skin and Soft Tissue Infections (SSTIs) are some of the most commonly occurring bacterial infections, with a wide range of possible aetiological pathogens and a considerable variety of clinical presentations and severity; from mild to severe life-threatening infections. Several classifications have been proposed based on a specific variable, such as anatomical localization, skin extension, progression rate, clinical presentation, severity and etiological agent. Areas covered: The last criteria allows the differentiation of SSTIs as mono-microbial and poly-microbial. Read More

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December 2018