88,994 results match your criteria Danish Medical Journal [Journal]


Electrophysiological and behavioral measures of some speech contrasts in varied attention and noise.

Hear Res 2018 Dec 6;373:1-9. Epub 2018 Dec 6.

Lund University Department of Psychology, Paradisgatan 5, Lund, 22100, Sweden. Electronic address:

This paper investigates the salience of speech contrasts in noise, in relation to how listening attention affects scalp-recorded cortical responses. The contrasts that were examined with consonant-vowel syllables, were place of articulation, vowel length and voice-onset time (VOT) and our analysis focuses on the correspondence between the effect of attention on the electrophysiology and the decrement in behavioral results when noise was added to the stimuli. Normal-hearing subjects (n = 20) performed closed-set syllable identification in no noise, 0, 4 and 8 dB signal-noise ratio (SNR). Read More

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December 2018

The DAHANCA 32 study: Electrochemotherapy for recurrent mucosal head and neck cancer.

Head Neck 2018 Dec 15. Epub 2018 Dec 15.

Department of Otorhinolaryngology, Head & Neck Surgery and Audiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.

Background: Electrochemotherapy is an established treatment for cutaneous tumors. This study aimed at determining efficacy of electrochemotherapy in recurrent head and neck cancer.

Methods: Phase II clinical trial in patients with recurrent head and neck carcinomas with no curative treatment options. Read More

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December 2018

Parents' experiences of donation to their child before kidney transplantation: A qualitative study.

J Clin Nurs 2018 Dec 14. Epub 2018 Dec 14.

Department of Clinical Institute, University of Southern, Denmark.

Aim And Objectives: To explore Parents' experiences of donation to their child before kidney transplantation.

Background: Transplantation is the treatment of choice for pediatric patients with end-stage renal disease. Living donor kidney transplantation has shown a higher long-term transplant survival compared to deceased donor transplantation and entails a more controllable process, with shorter waiting time. Read More

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December 2018

Disability and morbidity among older patients in the emergency department: a Danish population-based cohort study.

BMJ Open 2018 Dec 14;8(12):e023803. Epub 2018 Dec 14.

Department of Geriatric Medicine, Odense University Hospital, Odense, Denmark.

Objectives: The objective was to describe the prevalence of geriatric conditions among older medical patients in the emergency department (ED) and the association with admission, mortality, reattendance and loss of independency.

Design: Population-based prospective cohort study.

Setting: ED of a large university hospital. Read More

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December 2018

Non-Coding RNA in Pancreas and β-Cell Development.

Noncoding RNA 2018 Dec 13;4(4). Epub 2018 Dec 13.

Department of Science and Environment, Roskilde University, DK-4000 Roskilde, Denmark.

In this review, we provide an overview of the current knowledge on the role of different classes of non-coding RNAs for islet and β-cell development, maturation and function. MicroRNAs (miRNAs), a prominent class of small RNAs, have been investigated for more than two decades and patterns of the roles of different miRNAs in pancreatic fetal development, islet and β-cell maturation and function are now emerging. Specific miRNAs are dynamically regulated throughout the period of pancreas development, during islet and β-cell differentiation as well as in the perinatal period, where a burst of β-cell replication takes place. Read More

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December 2018

The Influence of Antidepressants on the Disease Course Among Patients With Crohn's Disease and Ulcerative Colitis-A Danish Nationwide Register-Based Cohort Study.

Inflamm Bowel Dis 2018 Dec 14. Epub 2018 Dec 14.

National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark.

Background: Psychiatric comorbidity might modify the disease course adversely in patients with inflammatory bowel disease (IBD). Treatment options include antidepressants, which, apart from improving mood, have anti-inflammatory properties that might modify the disease course. This nationwide study aimed to examine the influence of antidepressants on the disease course among patients with ulcerative colitis (UC) and Crohn's disease (CD). Read More

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December 2018
1 Read

Measuring mental well-being in Denmark: Validation of the original and short version of the Warwick-Edinburgh mental well-being scale (WEMWBS and SWEMWBS) and cross-cultural comparison across four European settings.

Psychiatry Res 2018 Dec 5;271:502-509. Epub 2018 Dec 5.

The Danish National Institute of Public Health, University of Southern Denmark, Studiestraede 6, 1455 Copenhagen, Denmark. Electronic address:

This study examined the psychometric properties of the Danish WEMWBS and its short version (SWEMWBS) in a Danish population sample, and compared scores in Denmark with scores representative of three other European settings. A total of 3,508 Danish men and women aged 16-95 filled out an electronic survey. Face validity was examined by cognitive interviews. Read More

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December 2018

Long-term residential exposure to PM, PM, black carbon, NO, and ozone and mortality in a Danish cohort.

Environ Int 2018 Dec 11;123:265-272. Epub 2018 Dec 11.

Danish Cancer Society Research Center, Strandboulevarden 49, 2100 Copenhagen Ø, Denmark; Department of Environmental Science, Aarhus University, Frederiksborgvej 399, P.O. Box 358, 4000 Roskilde, Denmark. Electronic address:

Air pollutants such as NO and PM have consistently been linked to mortality, but only few previous studies have addressed associations with long-term exposure to black carbon (BC) and ozone (O). We investigated the association between PM, PM, BC, NO, and O and mortality in a Danish cohort of 49,564 individuals who were followed up from enrollment in 1993-1997 through 2015. Residential address history from 1979 onwards was combined with air pollution exposure obtained by the state-of-the-art, validated, THOR/AirGIS air pollution modelling system, and information on residential traffic noise exposure, lifestyle and socio-demography. Read More

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December 2018
1 Read

Health risk assessment on N-nitrosodimethylamine in drinking water and food in major cities of China with disability-adjusted life years (DALYs).

Ecotoxicol Environ Saf 2018 Dec 11;170:412-417. Epub 2018 Dec 11.

Key Laboratory of Drinking Water Science and Technology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; Sino-Danish College, University of Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China.

In this study, a health risk assessment of N-nitrosodimethylamine (NDMA) in drinking water and food was conducted using disability-adjusted life years (DALYs) in major cities of China. Considering the numerous non-detected values found in drinking water samples, a zero-inflated model was employed to obtain a more precise NDMA concentration distribution function in drinking water. With exogenous chronic daily intake of 1. Read More

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December 2018

Contributions of climate change and vegetation greening to evapotranspiration trend in a typical hilly-gully basin on the Loess Plateau, China.

Sci Total Environ 2018 Nov 27;657:325-339. Epub 2018 Nov 27.

Key Laboratory of Water Cycle and Related Land Surface Processes, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.

Significant increases in vegetation cover on the Loess Plateau since the early 2000s have been well documented. However, the relevant hydrological effects are still unclear. Here, we investigated the changes in actual evapotranspiration (ET) from 2000 to 2016 and related them to climate change and vegetation greening in Yanhe River basin (YRB), a typical hilly-gully basin on the Loess Plateau, by using the remote-sensing based VIP model. Read More

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November 2018

Reproducibility of quantitative coronary computed tomography angiography in asymptomatic individuals and patients with acute chest pain.

PLoS One 2018 14;13(12):e0207980. Epub 2018 Dec 14.

Department of Cardiology, Rigshospitalet, Faculty of Health Sciences, University of Copenhagen, Copenhagen, Denmark.

Purpose: Quantitative computed tomography (QCT) provides important prognostic information of coronary atherosclerosis. We investigated intraobserver and interobserver QCT reproducibility in asymptomatic individuals, patients with acute chest pain without acute coronary syndrome (ACS), and patients with acute chest pain and ACS.

Methods: Fifty patients from each cohort, scanned between 01/02/2010-14/11/2013 and matched according to age and gender, were retrospectively assessed for inclusion. Read More

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December 2018
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Replication of newly proposed TNM staging system for medullary thyroid carcinoma: a nationwide study.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

C Godballe, Department of ORL Head and Neck Surgery and Audiology, Odense University Hospital, Odense, Denmark.

A recent study proposed new TNM groupings for better survival discrimination among stage groups for medullary thyroid carcinoma (MTC) and validated these groupings in a population-based cohort in the United States. However, it is unknown how well the groupings perform in populations outside the United States. Consequently, we conducted the first population-based study aiming to evaluate if the recently proposed TNM groupings provide better survival discrimination than the current American Joint Committee on Cancer (AJCC) TNM staging system (seventh and eighth edition) in a nationwide MTC cohort outside the United States. Read More

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December 2018

Mogens Schou (1918-2005): a scientist, a doctor and a lithium champion.

Bipolar Disord 2018 Dec 14. Epub 2018 Dec 14.

Aalborg University Hospital, Psychiatry, Aalborg, Denmark.

In November this year, we marked the 100th anniversary of the birthday of Mogens Schou, the great Danish clinical and basic scientist and a true giant of lithium research and treatment. Mogens Schou did more than anybody else in the world to establish lithium therapy, and without his assiduousness lithium may well have been forgotten. To commemorate his achievements a special symposium was organized in Copenhagen dedicated to lithium and the life time contributions of Mogens Schou. Read More

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December 2018
1 Read

The diabetic phenotype is preserved in myotubes established from type 2 diabetic subjects: a critical appraisal.

Authors:
Michael Gaster

APMIS 2019 Jan;127(1):3-26

Laboratory for Molecular Physiology, Department of Pathology and Department of Endocrinology, Odense University Hospital, Odense, Denmark.

Cultured human myotubes offer a unique model to distinguish between primary and environmental factors in the aetiology of insulin resistance in human skeletal muscle. The objective of this review was to summarize our and other group studies on insulin resistance in human myotubes established from lean, obese and type 2 diabetes (T2D) subjects. Overall, studies of human myotubes established from lean, obese and T2D subjects clearly show that part of the diabetic phenotype observed in vivo is preserved in diabetic myotubes. Read More

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January 2019

Subtyping of intraductal papillary mucinous neoplasms - pitfalls of MUC1 immunohistochemistry.

APMIS 2019 Jan 22;127(1):27-32. Epub 2018 Nov 22.

Department of Pathology, Copenhagen University Hospital Rigshospitalet, København, Denmark.

Intraductal papillary mucinous neoplasms (IPMNs) are precursor lesions of pancreatic ductal adenocarcinoma (PDAC). Current edition of WHO Classification of Tumors of the Digestive System recognizes four different subtypes (gastric, intestinal, pancreatobiliary, and oncocytic) and recommends analysis of mucin expression (MUC1, MUC2, MUC5AC, MUC6) as well as evaluation of architectural and cell differentiation patterns for correct classification. However, there is no consensus on MUC1 expression of IPMN-lesions in the literature. Read More

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January 2019

Enhanced Natural Killer Cell Immunotherapy by Rationally Assembling Fc Fragments of Antibodies onto Tumor Membranes.

Adv Mater 2018 Dec 14:e1804395. Epub 2018 Dec 14.

Chinese Academy of Sciences (CAS) Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology (NCNST), 11 Beiyitiao, Zhongguancun, Beijing, 100190, China.

Recent advances in cancer immunotherapy have exploited the efficient potential of natural killer (NK) cells to kill tumor cells through antibody-dependent cell-mediated cytotoxicity (ADCC). However, this therapeutic strategy is seriously limited by tumor antigen heterogeneity since antibodies can only recognize specific antigens. In this work, modified antibodies or their Fc fragments that can target solid tumors without the necessity of specific antigen presentation on tumors are developed. Read More

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December 2018

From democratic participation to civic resistance: the loss of institutional trust as an outcome of activism in the refugee solidarity movement.

Authors:
Jonas Toubøl

Br J Sociol 2018 Dec 12. Epub 2018 Dec 12.

Adding to the literature on non-institutional political action and trust, this article argues that the loss of institutional trust is not only a cause but also an outcome of political activism. Studying the Danish refugee solidarity movement in a mixed-methods research design including survey and qualitative interview data, the article shows that three kinds of activism - political activism, humanitarian activity, and civil disobedience - relate differently to the loss of trust in the institutions of the Parliament, the legal system, and the police. Political activism primarily affects a loss of trust in the Parliament due to low external efficacy and a closed political opportunity structure. Read More

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December 2018

Hyperpolarized [1- C] pyruvate as a possible diagnostic tool in liver disease.

Physiol Rep 2018 Dec;6(23):e13943

MR Research Centre, Aarhus University Hospital, Aarhus, Denmark.

Introduction of hyperpolarized magnetic resonance in preclinical studies and lately translation to patients provides new detailed in vivo information of metabolic flux in organs. Hyperpolarized magnetic resonance based on C enriched pyruvate is performed without ionizing radiation and allows quantification of the pyruvate conversion products: alanine, lactate and bicarbonate in real time. Thus, this methodology has a promising potential for in vivo monitoring of energetic alterations in hepatic diseases. Read More

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December 2018
3 Reads

[Limited evidence for effect and safety of propranolol for exam-related anxiety].

Ugeskr Laeger 2018 Dec;180(50)

Propranolol is often prescribed to younger people with exam-related performance anxiety. Evidence for effect as well as safety is, however, sparse for this non-approved indication. Furthermore, only relatively large pack sizes are available in Denmark. Read More

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December 2018

[Effects of glucagon-like peptides on gallbladder motility].

Ugeskr Laeger 2018 Dec;180(50)

As cases of gallbladder-related adverse events have been reported in patients treated with glucagon-like peptide (GLP)-1 receptor agonists and GLP-2 receptor agonists, studies have investigated the effects of these hormones on the enterohepatic circulation of bile acids and gallbladder motility. Results suggest, that bile acids and GLP-2 counteract postprandial cholecystokinin-mediated gallbladder contraction, while GLP-1 may delay gallbladder refilling. This provides important information on the effect and safety of drugs based on GLP-1 and GLP-2, respectively. Read More

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December 2018

[Intramedullary spinal cord tumour as differential diagnosis to bilateral muscle weakness].

Ugeskr Laeger 2018 Dec;180(50)

Intramedullary spinal cord tumours (IMSCT) are rare neoplasms, which can potentially lead to severe neurologic deficits. In this case report, an 83-year-old man presented with rapidly progressive bilateral muscle weakness developed within few weeks. MRI revealed a spinal cord tumour at the C7/Th1 vertebral level. Read More

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December 2018

[Diagnostics of congenital cytomegalovirus in Denmark].

Ugeskr Laeger 2018 Dec;180(50)

Congenital cytomegalovirus (cCMV) is the most common infectious cause of congenital malformations in Denmark. The disease is not notifiable, and there are no national data. A regional Danish prospective study from the 1970s found a cCMV incidence of 0. Read More

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December 2018

[Blind corticosteroid injection as primary treatment of trigger finger].

Ugeskr Laeger 2018 Dec;180(50)

Trigger finger (TF) is a common condition with a lifetime prevalence up to 2%. Local corticosteroid injection at the level of the A1 pulley is a frequently used and safe treatment for TF with cure rates around 50% in randomised controlled trials, while surgical release has cure rates near 100% but more severe complications. Blind local corticosteroid injection has the same effect as ultrasound-guided local corticosteroid injection on cure rates, and the effect remains the same, whether the steroid is placed intra-sheath or extra-sheath. Read More

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December 2018

[Melanonychia].

Ugeskr Laeger 2018 Dec;180(50)

Melanonychia is seen, when melanin is incorporated in the nail, which gives a band of dark discolouration of the nail. Nail discolouration is a common cause for patients to seek medical attention, and it is often benign. Melanonychia can be seen due to melanocytic proliferation (ungual naevi), benign hyperplasia (lentigo) and hypermelanosis (infections, traumas). Read More

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December 2018

[Christmas article. Significantly fewer acute hospital admissions on days off].

Ugeskr Laeger 2018 Dec;180(50)

The number of acute admissions in Danish hospitals is increasing and is causing recurrent overcrowding problems. There are fewer hospitalisations on days off, like weekends, public holidays and vacations, and this phenomenon is analysed in our review with data from the period 1.1. Read More

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December 2018

[Christmas article. When the hearth leads the way].

Ugeskr Laeger 2018 Dec;180(50)

Situs inversus is a medical condition with transposition of the organs in chest and abdomen. The condition may cause misdiagnosis due to inverted location of the origin of acute abdominal pain in cases of e.g. Read More

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December 2018

[Christmas article. The myth of women's menstrual synchronisation].

Authors:
Søren Mølgaard

Ugeskr Laeger 2018 Dec;180(50)

To solve the enigma of menstrual synchronisation, the relevant literature has been reviewed in this paper. A methodological discussion of studies in favour of the synchronisation hypothesis severely undermines the credibility of this hypothesis, and recent studies have been unable to observe the phenomenon in humans and primates. It is therefore concluded, that there is no substantial evidence of the hypothesis. Read More

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December 2018

[Taste from all perspectives].

Ugeskr Laeger 2018 Dec;180(50)

The taste buds seem to have a gatekeeper function to avoid uneatable or potentially toxic food and to be aware of dysfunctional sense of taste. However, taste has a wider function than avoiding illness. It is also the precondition for tastiness and pleasure, which is even as important in a health-promoting context. Read More

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December 2018

[Christmas article. Scientific spam].

Ugeskr Laeger 2018 Dec;180(50)

Introduction: Predatory publishing has led to an increasing amount of scientific spam mails addressed to medical researchers. This study aimed at characterising this spam further.

Methods: Prospective study of spam received during a three-month-period. Read More

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December 2018

[Christmas Article. String-mounted nameplates increase the risk of misidentification of doctors].

Ugeskr Laeger 2018 Dec;180(50)

Introduction: At Aarhus University Hospital, it has been decided, that nameplates should be attached to strings. Previously, they were mounted on needles. This has caused problems of misidentification of doctors among patients and especially for the senior physicians, because the string-mounted nameplates often face in the wrong direction. Read More

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December 2018

[Christmas article. Significant difference in plate prices in the Hvidovre Hospital canteen].

Ugeskr Laeger 2018 Dec;180(50)

Introduction: Following price hikes in the Hvidovre Hospital canteen and continual discussions concerning the unpredictability of meal prices we decided to examine, if there was a difference in the weight of canteen plates, and if the two available weight scales measured differently.

Methods: We initially conducted a pilot study and weighed 50 plates twice, once on each weight scale connected to the cash register in the canteen. After an interim analysis and a new power calculation, we weighed an additional 88 plates, but on one scale only. Read More

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December 2018

[Christmas article. Urine wheel (un-)folded - a modern version of the urine wheel].

Ugeskr Laeger 2018 Dec;180(50)

In 1492 Johannes de Ketham published the urine wheel which was thought to reveal imbalances of the four humours according to the colour of the urine. The urine wheel presented in this article is a foldable modern version linking the colours of urine to different diseases, food and drugs. Read More

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December 2018

[Christmas article. The influence of lunar phases on epilectic seizures].

Ugeskr Laeger 2018 Dec;180(50)

An old myth asserts, that the lunar phases influence epileptic seizures. This Christmas article examines the assertion by reviewing four articles about the correlation between the lunar phases and the frequency of seizures in patients with epilepsy and in patients with non-epileptic seizures. Hypotheses suggest, that sleep disturbances, melatonin level and nocturnal illumination may play a role in the relation between lunar phases and epileptic seizures. Read More

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December 2018

[Christmas article. MRI assessment of the optimal type of traditional pork roast and preparation method - a randomised blinded trial].

Ugeskr Laeger 2018 Dec;180(50)

Introduction: Pork roast is part of the traditional Danish Christmas meal and has been so for several hundreds of years. A novel cooking method is sous vide, in which the meat under vacuum is cooked for a long time at low temperature. Can MRI predict the optimal type of traditional pork roast and the optimal preparation method: oven or sous vide preparation?

Methods: Two different pork roasts, one from an ordinary pig and one from a pig from an organic farm, were divided in two and randomised to oven cooking or sous vide. Read More

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December 2018

Stort og småt fra redaktionen.

Authors:
Anja Pinborg

Ugeskr Laeger 2018 Dec;180(50)

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December 2018

Comorbidity among HHT patients and their controls in a 20 years follow-up period.

Orphanet J Rare Dis 2018 Dec 14;13(1):223. Epub 2018 Dec 14.

Odense Patient data Explorative Network (OPEN), Odense University Hospital/Department of Clinical Research, University of Southern Denmark, Odense, Denmark.

Background: Hereditary Haemorrhagic Telangiectasia (HHT) is an autosomal dominant genetic disorder with a wide variety of clinical manifestations due to the presence of multiple arteriovenous malformations in various tissues and organs.

Objective: To study the need for hospital admittance in a group of HHT patients and matched controls during a 20 years follow-up period commencing in 1995.

Methods: All HHT patients in the County of Funen, Denmark, were included. Read More

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December 2018

NonPrimordial Solar Mass Black Holes.

Phys Rev Lett 2018 Nov;121(22):221102

Service de Physique Théorique, Université Libre de Bruxelles (ULB), CP225 Boulevard du Triomphe, B-1050 Bruxelles, Belgium.

We propose a mechanism that can convert a sizable fraction of neutron stars into black holes with mass ∼1  M_{⊙}, too light to be produced via stellar evolution. We show that asymmetric fermionic dark matter of mass on the teraelectron volt scale, with attractive self-interaction within the range that alleviates the problems of collisionless cold dark matter, can accumulate in a neutron star and collapse, forming a black hole that converts the rest of the star to a solar mass black hole. We estimate the fraction of neutron stars that can become black holes without contradicting neutron star observations. Read More

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November 2018

Immunoprofiles of colorectal cancer from Lynch syndrome.

Oncoimmunology 2019 26;8(1):e1515612. Epub 2018 Sep 26.

The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre Hospital, Hvidovre, Denmark.

Colorectal cancers associated with Lynch syndrome are characterized by defective mismatch repair, microsatellite instability, high mutation rates, and a highly immunogenic environment. These features define a subset of cancer with a favorable prognosis and high likelihood to respond to treatment with anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) drugs. With the aim to define immune-evasive mechanisms and a potential impact hereof in colorectal cancers from Lynch syndrome hereditary cases with retained mismatch repair function, we immunohistochemically and transcriptionally profiled 270 tumors. Read More

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September 2018
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Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia.

Nat Commun 2018 Dec 13;9(1):5296. Epub 2018 Dec 13.

National Centre for Register-based Research, Aarhus University, Aarhus, 8210, Denmark.

Spatial mapping is a promising strategy to investigate the mechanisms underlying the incidence of psychosis. We analyzed a case-cohort study (n = 24,028), drawn from the 1.47 million Danish persons born between 1981 and 2005, using a novel framework for decomposing the geospatial risk for schizophrenia based on locale of upbringing and polygenic scores. Read More

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December 2018
1 Read

Surgical treatment and survival from colorectal cancer in Denmark, England, Norway, and Sweden: a population-based study.

Lancet Oncol 2018 Dec 10. Epub 2018 Dec 10.

Department of Population Health, London School of Hygiene & Tropical Medicine, London, UK.

Background: Survival from colorectal cancer has been shown to be lower in Denmark and England than in comparable high-income countries. We used data from national colorectal cancer registries to assess whether differences in the proportion of patients receiving resectional surgery could contribute to international differences in colorectal cancer survival.

Methods: In this population-based study, we collected data from all patients aged 18-99 years diagnosed with primary, invasive, colorectal adenocarcinoma from Jan 1, 2010, to Dec 31, 2012, in Denmark, England, Norway, and Sweden, from national colorectal cancer registries. Read More

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December 2018

New Insights into the Potential of Endogenous Redox Systems in Wheat Bread Dough.

Antioxidants (Basel) 2018 Dec 12;7(12). Epub 2018 Dec 12.

Enzyme and Protein Chemistry (EPC), Department of Systems Biology, Technical University of Denmark, Building 224, DK-2800 Kgs Lyngby, Denmark.

Various redox compounds are known to influence the structure of the gluten network in bread dough, and hence its strength. The cereal thioredoxin system (NTS), composed of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent thioredoxin reductase (NTR) and thioredoxin (Trx), is a major reducing enzymatic system that is involved in seed formation and germination. NTS is a particularly interesting tool for food processing due to its heat stability and its broad range of protein substrates. Read More

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December 2018

Anti-CRISPR-Based and CRISPR-Based Genome Editing of Rod-Shaped Virus 2.

Viruses 2018 Dec 8;10(12). Epub 2018 Dec 8.

Danish Archaea Centre, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen, Denmark.

Genetic engineering of viruses has generally been challenging. This is also true for archaeal rod-shaped viruses, which carry linear double-stranded DNA genomes with hairpin ends. In this paper, we describe two different genome editing approaches to mutate the rod-shaped virus 2 (SIRV2) using the archaeon LAL14/1 and its derivatives as hosts. Read More

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December 2018

Complex spatio-temporal distribution and genomic ancestry of mitochondrial DNA haplogroups in 24,216 Danes.

PLoS One 2018 13;13(12):e0208829. Epub 2018 Dec 13.

Department for Congenital Disorders, Statens Serum Institut, Copenhagen, Denmark.

Mitochondrial DNA (mtDNA) haplogroups (hgs) are evolutionarily conserved sets of mtDNA SNP-haplotypes with characteristic geographical distribution. Associations of hgs with disease and physiological characteristics have been reported, but have frequently not been reproducible. Using 418 mtDNA SNPs on the PsychChip (Illumina), we assessed the spatio-temporal distribution of mtDNA hgs in Denmark from DNA isolated from 24,642 geographically un-biased dried blood spots (DBS), collected from 1981 to 2005 through the Danish National Neonatal Screening program. Read More

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December 2018

[Development of “MADE”, a French Job exposure matrix for evaluation of biomechanical exposure].

Sante Publique 2018 May June;30(3):333-337

Objective: This paper presents the stages of development of an occupational biomechanical exposure matrix and preliminary reliability and validity indicators.

Methods: The expertise-based job exposure matrix, called "MADE" (for "difficult physical conditions and job matrix"), was developed from the French and international classification of jobs for 17 biomechanical exposures. Three pairs of investigators independently rate the frequency and intensity of exposure of each job from 0 to 5; discordant scores within pairs (mean difference >20% for each biomechanical exposure considered) were discussed collectively. Read More

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December 2018

Diamond/Porous Titanium Nitride Electrodes With Superior Electrochemical Performance for Neural Interfacing.

Front Bioeng Biotechnol 2018 15;6:171. Epub 2018 Nov 15.

Laboratory for Stem Cell Research, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.

Robust devices for chronic neural stimulation demand electrode materials which exhibit high charge injection () capacity and long-term stability. Boron-doped diamond (BDD) electrodes have shown promise for neural stimulation applications, but their practical applications remain limited due to the poor charge transfer capability of diamond. In this work, we present an attractive approach to produce BDD electrodes with exceptionally high surface area using porous titanium nitride (TiN) as interlayer template. Read More

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November 2018

infective endocarditis in a healthy adult.

IDCases 2018 17;14:e00471. Epub 2018 Nov 17.

Internal Medicine Residency Department of Medicine Rutgers Robert Wood Johnson Medical School, CAB 7320, 125 Paterson Street, New Brunswick, NJ 08903, United States.

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November 2018

Introduction of Mercury-Free Gold Extraction to Small-Scale Miners in the Cabo Delgado Province in Mozambique.

J Health Pollut 2018 Sep 10;8(19):180909. Epub 2018 Sep 10.

The Research Unit for General Practice, University of Copenhagen, Denmark.

Background: The majority of small-scale gold miners worldwide, including those in Mozambique, use mercury to extract gold. Over the last fifty years, gold production from small-scale mining has been accelerating and consequently the amount of mercury released to the environment has increased dramatically, causing major global health problems. In 2018, a team from the Danish non-governmental organization Diálogos introduced the mercury-free gold extraction method in the Cabo Delgado province in Mozambique in the villages of Waqueia and Nanlia. Read More

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September 2018

How does childhood socioeconomic position affect overweight and obesity in adolescence and early adulthood: a longitudinal study.

BMC Obes 2018 3;5:34. Epub 2018 Dec 3.

1Danish Ramazzini Centre, Department of Occupational Medicine, University Research Clinic, Regional Hospital West Jutland, Gl. Landevej 61, 7400 Herning, Denmark.

Background: Childhood socioeconomic position (SEP) has previously been associated with increased risk of overweight among children and adolescents. However, it remains uncertain whether the timing of exposure is important in relation to developing overweight in early adulthood. We aimed to examine how SEP during early (0-8 years) and late childhood (9-14 years) relates to overweight at age 15, 18 and 21. Read More

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December 2018