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J Med Case Rep 2021 Feb 17;15(1):69. Epub 2021 Feb 17.

Department of Pathology and Laboratory Medicine, Aga Khan University Hospital, Karachi, Pakistan.

Background: Retiform Hemangioendothelioma (RH) is an extremely rare vascular tumor of intermediate biological behavior, which is prone to local recurrence but rarely shows metastasis to distant sites. It may harbor areas resembling Dabska tumor in some cases and angiosarcoma, which in its well differentiated form may exhibit similar pathological appearance in some areas, making it problematic to rule out a possibility of a malignant diagnosis on a core biopsy. Therefore, complete surgical resection with negative margins is essential for accurate diagnosis and local control. Read More

Am J Dermatopathol 2021 Feb;43(2):119-136

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain; and.

Abstract: Intravascular proliferations of the skin are clinically heterogeneous and may present with a wide range of clinical features, including violaceous papules, nodules, plaques, or other unspecific cutaneous lesions. Histopathologically, these conditions are characterized by proliferation of different cell types within the lumina of dermal vessels and endothelial cell hyperplasia. Immunohistochemistry is the best tool to identify the nature of the intravascular proliferating cells and the type of involved vessel. Read More

An Bras Dermatol 2020 Mar - Apr;95(2):214-216. Epub 2020 Feb 12.

Pathological Anatomy Service, Studart & Studart Laboratory, Salvador, BA, Brazil.

Papillary intralymphatic angioendothelioma (Dabska tumor) is a rarely metastasizing lymphatic vascular neoplasm that usually affects children and young adults. The majority of these cases occur in soft tissues of extremities, and to date less than 40 cases have been described. Despite the generally indolent evolution, can be locally invasive with the potential to metastasize. Read More

Indian J Pathol Microbiol 2020 Jan-Mar;63(1):122-124

Department of Pathology, IPGME and R, Kolkata, West Bengal, India.

Retiform hemangioendothelioma is a rare vascular neoplasm of intermediate grade, the diagnosis of which can be challenging. We report a case of 35-year-old man with swelling in the postauricular region. He had undergone FNAC which had revealed blood only. Read More

Anal Bioanal Chem 2019 May 8;411(13):2925-2935. Epub 2019 Apr 8.

, Dabska 18H 52-571, Kraków, Poland.

We present an electrochemical DNA detection strategy based on self-assembled ferrocene-cored poly(amidoamine) dendrimers for the detection of a gene relevant to breast cancer. The chemisorption of three ferrocene-cored poly(amidoamine) generations and hybridization of single-stranded DNA on a Au electrode were studied by cyclic voltammetry and differential pulse voltammetry. The biosensor demonstrated high sensitivity of 0. Read More

Ocul Oncol Pathol 2018 Jun 12;4(4):230-235. Epub 2018 Jan 12.

Department of Ophthalmic Pathology, Thomas Jefferson University, Philadelphia, PA, USA.

Primary cutaneous angiosarcoma is a rare vasoformative malignant neoplasm that can present a diagnostic and therapeutic challenge. We describe a 76-year-old Caucasian man with right upper eyelid swelling and nodularity, initially suspected clinically to represent either ocular adnexal lymphoma or basal cell carcinoma. Incisional biopsy and wide resection of the mass with frozen section control of margins were interpreted as compatible with hobnail (Dabska-retiform) hemangioendothelioma. Read More

Dig Endosc 2018 May 25;30(3):390. Epub 2018 Mar 25.

Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.

Clin Sarcoma Res 2018 30;8. Epub 2018 Jan 30.

1Department of Pathology, Rizzoli Institute, Bologna, Italy.

Background: Papillary intralymphatic angioendothelioma (PILA) is a locally aggressive, rarely metastasizing vascular tumor, generally occurring in the soft tissues, with less than 40 cases described in the literature and only three cases reported in bone.

Case Presentation: We describe the case of a 51-year-old male with an intraosseous PILA of the proximal edge of his left clavicle and two other lesions evident on imaging. The patient was treated with marginal resection of the clavicle lesion but was lost to follow-up 1 month after surgery. Read More

Histol Histopathol 2017 Dec 1;32(12):1239-1279. Epub 2017 Aug 1.

Department of Cell Biology and Histology, School of Medicine, Campus of International Excellence, "Campus Mare Nostrum", IMIB-Arrixaca, University of Murcia, Murcia, Spain.

We review the morpho-functional basis of the different types of angiogenesis and report our observations, including the formation of angiogenesis-related secondary structures. First of all, we consider the following issues: a) conceptual differences between angiogenesis and vasculogenesis, b) incidence of angiogenesis in pre- and postnatal life, c) regions of vascular tree with angiogenic capacity, d) cells (endothelial cells, pericytes, CD34+ adventitial stromal cells of the microvasculature and inflammatory cells) and extracellular matrix components involved in angiogenesis, e) events associated with angiogenesis, f) different types of angiogenesis, including sprouting and intussusceptive angiogenesis, and other angiogenic or vascularization forms arising from endothelial precursor cells (postnatal vasculogenesis), vasculogenesis mimicry, vessel co-option and piecemeal angiogenesis. Subsequently, we consider the specific morpho-functional characteristics of each type of angiogenesis. Read More

J Cutan Pathol 2017 Jan 2;44(1):107-109. Epub 2016 Nov 2.

Dermatek, Centro Médico Teknon, Barcelona, Spain.

J Eur Acad Dermatol Venereol 2016 Oct 31;30(10):e59-e61. Epub 2015 Aug 31.

Department of Dermatology, Paracelsus Medical University Salzburg, Muellner Hauptstraße 48, A-5020, Salzburg, Austria.

Zhonghua Bing Li Xue Za Zhi 2015 Jul;44(7):480-5

E-mail:

Objective: To further elucidate the clinical and pathologic features of retiform hemangioendothelioma (RH) and its clinical spectrum.

Methods: Eight cases of RH were reviewed. The clinicopathologic profiles, immunophenotypes and outcome data were investigated. Read More

J Cutan Pathol 2016 Mar 12;43(3):258-62. Epub 2015 Oct 12.

Department of Dermatology, Fundación Jiménez Díaz, Madrid, Spain.

Dabska tumor, also known as papillary intralymphatic angioendothelioma (PILA), is a locally aggressive hemangiendothelioma characterized by intravascular papillary proliferations of atypical endothelial cells. Besides PILA, papillary tufts lined by hobnail endothelial cells have been rarely described in vascular proliferations. We report two cases of acquired hemangiomas, which focally showed this finding. Read More

Pol J Pathol 2015 Mar;66(1):1-2

Diagn Pathol 2013 Sep 24;8:160. Epub 2013 Sep 24.

Department of Pathology, The First Affiliated Hospital, Sun Yat-sen university, 58, Zhongshan Road II, Guangzhou 510080, China.

Unlabelled: Papillary intralymphatic angioendothelioma (PILA) or Dabska tumor is extremely rare, and often affects the skin and subcutaneous tissues of children. Since its first description by Dabska, only a few intraosseous cases have been described in the literature and none of them presents with multifocal osteolytic lesion of bones. We present a case of unusual multifocal intraosseous PILA in facial bones occurring in a 1 year 3 month old male child. Read More

Eplasty 2013 10;13:e46. Epub 2013 Sep 10.

Divisions of General Surgery, Rutgers-Robert Wood Johnson Medical School, New Brunswick.

Objective: The Dabska tumor is a rare low-grade angiosarcoma first described in 1969 by Maria Dabska. Approximately 30 cases of varying presentations have been reported since its initial description.

Methods: We describe a case of a 23-year-old woman presenting with a massive recurrent left flank hemangioendothelioma, at final resection diagnosed to be an endovascular papillary angioendothelioma (Dabska tumor). Read More

Case Rep Pathol 2013 31;2013:531479. Epub 2013 Mar 31.

Institute of Pathology, University of Cologne Medical Center, 50937 Cologne, Germany.

Papillary intralymphatic angioendothelioma is a rare, low-grade neoplasm of lymphatic channels that usually presents intradermally or subcutaneously. We report the case of a 24-year-old male presenting with an isolated intratesticular palpable mass and symptoms of testicular pain. Preoperative ultrasound examination showed an irregular, heterogeneous mass. Read More

Coll Antropol 2012 Nov;36 Suppl 2:171-2

Dr. Ivo Pedisić, General Hospital, Department of ENT Surgery, Sisak, Croatia.

In 1969 Dabska and her colleagues described for the first time this rare malignant tumour, also later known as a malignant endovascular papillary angioendothelioma of childhood. Overall, depending amongst other factors on its location, it is thought to have a generally favourable prognosis and a wide local excision seems to be the treatment of choice. We here present a very rare and unusual case of a 63 year old woman with a 20 year history of slow-growing right buccal dermatological lesion which resembled a common mole. Read More

Semin Diagn Pathol 2013 Feb;30(1):29-44

Department of Dermatology, Fundación Jiménez Díaz, Universidad Autónoma, Madrid, Spain.

Hemangioendothelioma is the term used to name those vascular neoplasms that show a borderline biological behavior, intermediate between entirely benign hemangiomas and highly malignant angiosarcomas. Although originally spindle cell hemangioendothelioma was proposed as a specific clinicopathologic variant of hemangioendothelioma, currently, it is considered as an entirely benign lesion, and thus, the name spindle cell hemangioma seems to be the most accurate for this lesion. Authentic hemangioendotheliomas involving the skin and soft tissues include papillary intralymphatic angioendothelioma (also known as Dabska tumor), retiform hemangioendothelioma, kaposiform hemangioendothelioma, epithelioid hemangioendothelioma, pseudomyogenic hemangioendothelioma (also known as epithelioid sarcoma-like hemangioendothelioma), and composite hemangioendothelioma. Read More

Pediatr Neurosurg 2012 21;48(1):48-50. Epub 2012 Jul 21.

Department of Pathology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India.

Encephaloceles arise from developmental defects in neural tube formation. These lesions contain brain and meninges which herniate through a defect in the skull. These may present as isolated malformations or rarely be associated with brain tumors. Read More

Histopathology 2011 Nov 18;59(5):1027-9. Epub 2011 Oct 18.

Am J Dermatopathol 2011 Oct;33(7):e84-7

Department of Pathology, Necker-Enfants Malades Hospital, APHP, Université Paris Descartes, Paris, France.

Retiform hemangioendothelioma (RH) is a rare low-grade malignancy angiosarcoma, with a high rate of local recurrence and a low metastatic risk. A 6 year-old girl with a large cervical cystic lymphangioma diagnosed by ultrasound and Doppler ultrasound, which showed a large multiloculated anechoic cyst with no flow. The lymphangioma was treated with injections of Picibanil (OK-432). Read More

Diagn Cytopathol 2011 Jul 2;39(7):514-6. Epub 2010 Nov 2.

Department of Pathology, Rajendra Institute of Medical Sciences, Ranchi, India.

Here we described a rare case of malignant endovascular papillary angioendothelioma (Dabska tumor) in an adult female. On fine needle aspiration, the smear showed many small clusters of tumor cells with rosettoid arrangement along with papillary fragments with fibrovascular core and hobnail like arrangement of the cells. Histopathological examination revealed a vascular tumor in the form of papillary projection into the vascular lumina, lined by atypical endothelial cells. Read More

Hum Pathol 2011 Jul;42(7):913-7

Dermatology and Pathology, New Jersey Medical School, Newark, NJ 07103, USA.

There is only one cancer to our knowledge named in honor of its female describer, the Dąbska tumor. Maria Dąbska was a brave hero of the Warsaw Resurrection of 1944 who survived deportation to Germany to graduate from medical school in Gdańsk and pursue a career in pathology, for which her research on the Dąbska tumor, breast cancer, sweat gland tumors, keratoacanthoma, soft tissue sarcomas, bone pathology, parachordoma, melanoma, and other entities remains salient. Working behind the Iron Curtain, she nevertheless achieved international recognition, yet few today are cognizant of her and her accomplishments. Read More

Pathol Res Pract 2011 May 11;207(5):327-31. Epub 2011 Mar 11.

Division of Diagnostic Pathology, National Hospital Organization Hokkaido Cancer Center, Sapporo, Japan.

Extra-axial soft tissue chordoma is rare. We report a case of extra-axial soft tissue chordoma of the right wrist in an 87-year-old man. The tumor was large, and the cut surface showed multinodular and myxoid appearance. Read More

J Pediatr Surg 2011 Jan;46(1):e25-8

Division of Plastic Surgery, Department of Surgery, College of Medicine, Milton S. Hershey Medical Center, The Pennsylvania State University, Hershey, PA 17033, USA.

Endovascular papillary angioendothelioma, or Dabska tumor, was first presented in 1969 by Maria Dabska where she presented cases occurring in 6 children. The tumor was described as being a low-grade angiosarcoma characterized by papillary endovascular proliferations of atypical endothelial cells and anastomosing vascular channels within the dermis. Since its original description, only 30 case reports have been written describing the varying presentation, clinical course, and histopathology of this tumor. Read More

Neuro Endocrinol Lett 2010 ;31(4):454-6

Department of Pathology District Specialist Hospital, and Department of Surgery, Medical University of Silesia, Tychy, Poland.

We report an angiosarcoma arising within a malignant endovascular papillary angioendothelioma (Dabska tumor) in soft tissue of the upper thigh/buttock of a 42-year-old woman. Although neoplastic progression within a vascular tumor of an existing low-grade lesion into DT has been described so far, we seem to be the first to report transformation of DT into an angiosarcoma. Read More

Dermatol Online J 2010 Apr 15;16(4). Epub 2010 Apr 15.

University of Minnesota, USA.

The term angiosarcoma, encompasses several neoplasms, all of which exhibit a malignant process derived from endothelial cells of the vessels. The most common form of angiosarcoma is highly aggressive, often fatal, and usually affects the head and neck region of elderly white men. Other low-grade forms of angiosarcoma, including papillary intralymphatic angioendothelioma, also known as Dabska tumor, are less invasive, affect a wider age range, and offer a better prognosis. Read More

Cesk Patol 2009 Jul;45(3):72-4

Ustav patologickej anatómie Jesseniovej lekárskej fakulty a Martinskej fakultnej nemocnice, Martin.

Retiform hemangioendothelioma (RHE) is a rare vascular tumoriform lesion characterized by rete testis--like vascular structures. RHE belongs to a group of vascular tumors of intermediate malignancy and together with Dabska tumor form a category of so-called hobnail hemangioendotheliomas. Authors present a case of a 8-year-old girl with RHE which was located in right calf and measured 12 x 8 mm. Read More