3,096 results match your criteria DNA and Cell Biology [Journal]


Cytosine Methylation of Isoflavone Synthase Gene in the Genic Region Positively Regulates Its Expression and Isoflavone Biosynthesis in Soybean Seeds.

DNA Cell Biol 2019 Apr 24. Epub 2019 Apr 24.

1 Division of Biochemistry, ICAR-Indian Agricultural Research Institute, New Delhi, India.

Plants, being sessile organisms, have evolved several dynamic mechanisms of gene regulation. Epigenetic modification especially cytosine methylation and demethylation actively regulates the expression of genes. To understand the role of cytosine methylation during isoflavonoid biosynthesis and accumulation, we performed cytosine methylation analysis in the coding region of two isoforms and gene, in two contrasting soybean genotypes differing in total isoflavone content (NRC37: high isoflavone; and NRC7: low isoflavone). Read More

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http://dx.doi.org/10.1089/dna.2018.4584DOI Listing

Intronic Polymorphisms in Gene of Second Heart Field as Risk Factors for Human Congenital Heart Disease in a Chinese Population.

DNA Cell Biol 2019 Apr 23. Epub 2019 Apr 23.

1 Center for Cardiac Surgery, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.

Transcriptional factors and signaling factors in the second heart field (SHF) contribute to cardiac development. However, the associations of intronic gene variants in the SHF with congenital heart disease (CHD) remain ununderstood. Ten single nucleotide polymorphisms (SNPs) from our previous sequencing data were selected and then genotyped in 383 CHD patients and 384 healthy controls in a Chinese population. Read More

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http://dx.doi.org/10.1089/dna.2018.4254DOI Listing

microRNA-370 Promotes Cell Growth by Targeting WNK2 in Breast Cancer.

DNA Cell Biol 2019 Apr 22. Epub 2019 Apr 22.

Central Hospital of Zibo, Zhangdian District, Zibo, Shandong, China.

Aberrant expression of microRNA-370 (miR-370) has been found in many types of human cancers. In non-small cell lung cancer, miR-370 is a tumor suppressor with decreased expression. In prostate cancer, it is an oncogene with overexpression. Read More

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https://www.liebertpub.com/doi/10.1089/dna.2018.4602
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http://dx.doi.org/10.1089/dna.2018.4602DOI Listing
April 2019
2 Reads

Forkhead Box C2 Attenuates Lipopolysaccharide-Induced Cell Adhesion via Suppression of Intercellular Adhesion Molecule-1 Expression in Human Umbilical Vein Endothelial Cells.

DNA Cell Biol 2019 Apr 17. Epub 2019 Apr 17.

1 Laboratory Medicine Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

Atherosclerosis is a chronic vascular inflammatory disease that involves diverse cell types and circulating regulatory factors, including intercellular adhesion molecule (ICAM)-1, a proinflammatory cytokine. Lipopolysaccharides (LPS) increase ICAM-1 expression and promote cell adhesion, but the mechanism is not clear. We found that LPS induced time- and dose-regulated upregulation of ICAM-1 expression and downregulation of forkhead box protein C2 (Foxc2) expression in human umbilical vein endothelial cells (HUVECs). Read More

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http://dx.doi.org/10.1089/dna.2019.4663DOI Listing

Identification and Characterization of the Anillin Gene in Silkworm.

DNA Cell Biol 2019 Apr 13. Epub 2019 Apr 13.

1 State Key Laboratory of Silkworm Genome Biology, Biological Science Research Center, Southwest University, Chongqing, China.

Anillin is an actin binding protein and plays crucial roles during mitotic cell cycle progression in metazoan. However, the sequence and functions of the Anillin gene have not been yet characterized in the silkworm, Bombyx mori. In this study, we cloned the full-length cDNA sequence of the silkworm Anillin (BmAnillin) gene. Read More

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http://dx.doi.org/10.1089/dna.2019.4660DOI Listing

ABCB1 (C1236T) Polymorphism Affects P-Glycoprotein-Mediated Transport of Methotrexate, Doxorubicin, Actinomycin D, and Etoposide.

DNA Cell Biol 2019 Apr 12. Epub 2019 Apr 12.

2 Department of Pharmacy, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.

P-glycoprotein (P-gp), encoded by the ABCB1 (ATP-binding cassette transporter superfamily B member 1) gene, is a transport protein involved in the efflux and distribution of the osteosarcoma drugs methotrexate, doxorubicin, actinomycin D, and etoposide. In vivo studies indicate a close relationship between the ABCB1 (C1236T) single-nucleotide polymorphism (SNP) and the efficacy of these drugs. The purpose of this research was to elucidate the effect of ABCB1 (C1236T) polymorphism on P-gp-mediated efflux of osteosarcoma drugs. Read More

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http://dx.doi.org/10.1089/dna.2018.4583DOI Listing
April 2019
2 Reads

Alterations in DNA Methylation Status Associated with Gulf War Illness.

DNA Cell Biol 2019 Mar 28. Epub 2019 Mar 28.

3 Institute for Neuro Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, Florida.

Gulf War Illness (GWI) affects about 25% of Persian Gulf veterans with a cluster of chronic symptoms, including immune dysfunction and neurological issues. Recent studies implicate gene expression changes in immune function to be associated with GWI. Since DNA methylation can regulate such changes in gene expression, and disruption of DNA methylation pattern is implicated in various immune and neurological diseases, we aimed to study the DNA methylation patterns in peripheral blood mononuclear cells from GWI patients. Read More

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http://dx.doi.org/10.1089/dna.2018.4469DOI Listing

Wnt3a Activates the WNT-YAP/TAZ Pathway to Sustain CDX2 Expression in Bovine Trophoblast Stem Cells.

DNA Cell Biol 2019 Mar 21. Epub 2019 Mar 21.

1 State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestocks, Inner Mongolia University, Hohhot, China.

Trophoblast stem cells (TSCs), the precursors of placental cells, are effective for studying placental formation in vitro. Using a dual inhibition (2i) medium and mixed L-Wnt3a/mouse embryonic fibroblast feeder cells, we previously established the bovine trophoblast cell line BTS-1. In this study, we used bovine fetal fibroblasts and added Wnt3a to the 2i medium to establish another bovine TSC line (BTSW). Read More

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http://dx.doi.org/10.1089/dna.2018.4458DOI Listing
March 2019
2 Reads
2.055 Impact Factor

Lack of Association Between CTLA-4 Genetic Polymorphisms and Noncardiac Gastric Cancer in a Chinese Population.

DNA Cell Biol 2019 Mar 19. Epub 2019 Mar 19.

1 First Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a key negative immunoregulatory molecule with characteristics of gene polymorphisms. Genetically predisposed CTLA-4 alteration in humans was associated with gastric cancer (GC) development. To explore the association of CTLA-4 polymorphism with susceptibility of noncardiac GC (NCGC), 490 NCGC patients and 1476 control individuals were studied. Read More

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http://dx.doi.org/10.1089/dna.2018.4555DOI Listing
March 2019
1 Read
2.055 Impact Factor

Regulation of Acetylation in High Mobility Group Protein B1 Cytosol Translocation.

DNA Cell Biol 2019 Mar 15. Epub 2019 Mar 15.

Department of Infectious Diseases, Renmin Hospital of Wuhan University, Wuhan, China.

High mobility group protein B1 (HMGB1) is a nonhistone that mainly binds to nucleus DNA. As an important late inflammatory transmitter, extracellular HMGB1 is involved in the inflammatory immune response, tumor growth, infiltration, and metastasis. HMGB1 is actively released by activated inflammatory cells or passively released by necrotic cells. Read More

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http://dx.doi.org/10.1089/dna.2018.4592DOI Listing
March 2019
3 Reads

Integrative microRNA-mRNA Analysis of Muscle Tissues in Qianhua Mutton Merino and Small Tail Han Sheep Reveals Key Roles for oar-miR-655-3p and oar-miR-381-5p.

DNA Cell Biol 2019 Mar 13. Epub 2019 Mar 13.

1 College of Animal Science and Technology, Jilin Agricultural University, Changchun, China.

The Qianhua Mutton Merino (QHMM) is a new variety of sheep (Ovis aries) with improved meat performance compared with the traditional Small Tail Han (STH) sheep variety. We recently reported the transcriptome profiling of longissimus muscle tissues between QHMM and STH sheep. In the present study, we aimed to evaluate key micro (mi)RNA-mRNA networks associated with sheep muscle growth and development. Read More

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https://www.liebertpub.com/doi/10.1089/dna.2018.4408
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http://dx.doi.org/10.1089/dna.2018.4408DOI Listing
March 2019
6 Reads

The SDF1/CXCR7 Signaling Axis Participates in Angiogenesis in Degenerated Discs Via the PI3K/AKT Pathway.

DNA Cell Biol 2019 Mar 13. Epub 2019 Mar 13.

Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.

Degenerative disc disease (DDD) is the main cause of low back pain, and the ingrowth of new blood vessels is one of its pathological features. The stromal cell-derived factor 1 (SDF1)/CXCR7 signaling axis plays a role in these physiological and pathological activities. The aims of this study were to explore whether this signaling axis participates in the angiogenesis of degenerated intervertebral discs (IVDs) and to define its underlying mechanism. Read More

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http://dx.doi.org/10.1089/dna.2018.4531DOI Listing
March 2019
5 Reads

An 85-Gene Coexpression Module for Progression of Hypertension-Induced Spontaneous Intracerebral Hemorrhage.

DNA Cell Biol 2019 Mar 6. Epub 2019 Mar 6.

1 Department of Neurosurgery, The Affiliated Hospital of Qingdao University, Qingdao, China.

Intracerebral hemorrhage (ICH) represents the most lethal form of stroke. We sought to identify potential genes that might contribute to progression of hypertension-induced spontaneous ICH (HIS-ICH). RNA-sequencing data set of cerebral vessel samples from HIS-ICH mice and normal mice was obtained from the Gene Expression Omnibus. Read More

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http://dx.doi.org/10.1089/dna.2018.4425DOI Listing
March 2019
3 Reads
2.055 Impact Factor

Mechanism of Low Expression of miR-30a-5p on Epithelial-Mesenchymal Transition and Metastasis in Ovarian Cancer.

DNA Cell Biol 2019 Apr 6;38(4):341-351. Epub 2019 Mar 6.

The Second Department of Gynecology, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, Shenyang, China.

Metastasis of ovarian cancer is regulated by microRNAs. This study focused on the effects of miR-30a-5p on ovarian cancer migration and invasion. Our results showed that the miR-30a-5p and mucin type O-glycan biosynthesis are closely related to ovarian cancer, and that miR-30a-5p was downregulated in ovarian cancer cells. Read More

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https://www.liebertpub.com/doi/10.1089/dna.2018.4396
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http://dx.doi.org/10.1089/dna.2018.4396DOI Listing
April 2019
4 Reads

Early Stage Biomarkers Screening of Prostate Cancer Based on Weighted Gene Coexpression Network Analysis.

DNA Cell Biol 2019 Mar 5. Epub 2019 Mar 5.

1 Department of Urology, Tianjin Institute of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Although the morbidity and mortality rates of prostate cancer (PCa) are considerably high, many PCas are characterized as indolent and slow growing, which do not require overtreatment. Overdiagnosis and overtreatment of early detected PCa are an emerging problem, owing to a lack of biomarkers that detect advanced disease at an earlier stage. In this study, RNA-Seq data of 57,045 genes for 495 PCa samples and 52 normal samples in the The Cancer Genome Atlas (TCGA) database were downloaded. Read More

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http://dx.doi.org/10.1089/dna.2018.4406DOI Listing
March 2019
5 Reads
2.055 Impact Factor

Upregulation of SPAG6 in Myelodysplastic Syndrome: Knockdown Inhibits Cell Proliferation Via AKT/FOXO Signaling Pathway.

DNA Cell Biol 2019 Mar 5. Epub 2019 Mar 5.

Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China.

Recently, sperm-associated antigen 6 (SPAG6), a member of the cancer-testis antigen family, has been shown to be involved in tumorigenesis. An increasing number of studies have shown that SPAG6 expression is associated with the pathogenesis of myelodysplastic syndrome (MDS). However, the mechanism has not been clearly elucidated. Read More

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http://dx.doi.org/10.1089/dna.2018.4521DOI Listing
March 2019
3 Reads
2.055 Impact Factor

Crosstalk Between the Microbiome and Gestational Immunity in Autism-Related Disorders.

DNA Cell Biol 2019 Feb 28. Epub 2019 Feb 28.

1 Department of Neuroscience, Center for Brain Immunology and Glia (BIG), University of Virginia, Charlottesville, Virginia.

The etiologies of most neurodevelopmental disorders, including autism spectrum disorder (ASD), remain incompletely understood. However, recent epidemiological and experimental data suggest that dysregulated maternal immune activation (MIA) can impede normal brain maturation and promote the development of autism-related phenotypes. Indeed, our studies and work by others demonstrate that offspring born to pregnant animals that were exposed to immune activators develop many of the defining behavioral features of ASD, including abnormalities in social preference, communicative impairments, and repetitive/stereotyped behaviors. Read More

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http://dx.doi.org/10.1089/dna.2019.4653DOI Listing
February 2019
1 Read

Association Between AXIN1 Gene Polymorphisms and Dilated Cardiomyopathy in a Chinese Han Population.

DNA Cell Biol 2019 Feb 27. Epub 2019 Feb 27.

1 Department of Cardiology, West China Hospital of Sichuan University, Chengdu, P.R. China.

Dilated cardiomyopathy (DCM) is a common type of cardiomyopathy. The pathogenesis of DCM remains unclear and involves varied genes. AXIN1 is a crucial gene in regulating various functions in cells, it encodes protein Axin1, which regulates the assembly and disassembly of β-catenin destruction complex. Read More

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http://dx.doi.org/10.1089/dna.2018.4567DOI Listing
February 2019
2 Reads

Transcriptome-Wide Characterization and Functional Identification of the Aquaporin Gene Family During Drought Stress in Common Vetch.

DNA Cell Biol 2019 Apr 26;38(4):374-384. Epub 2019 Feb 26.

State Key Laboratory of Grassland Agro-ecosystems, Key Laboratory of Grassland Livestock Industry Innovation, Ministry of Agriculture and Rural Affairs, Engineering Research Center of Grassland Industry, Ministry of Education, College of Pastoral Agriculture Science and Technology, Lanzhou University, Lanzhou, P.R. China.

Aquaporins (AQPs) are transmembrane channels that are essential for the movement of water and other small molecules between biofilms in various physiological processes in plants. In this study, based on transcriptome-wide data, we identified and described a total of 21 AQP genes in common vetch (Vicia sativa subsp. sativa), which is an economically important pasture legume worldwide. Read More

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http://dx.doi.org/10.1089/dna.2018.4562DOI Listing

Evolutionary Analysis of the F-Box Gene Family in Saccharomycetaceae.

DNA Cell Biol 2019 Apr 25;38(4):333-340. Epub 2019 Feb 25.

2 State Key Laboratory of Crop Stress Biology in Arid Areas and College of Life Sciences, Northwest A&F University, Yangling, China.

F-box proteins are a core component of Skp1-Cul1-F-box (SCF) ubiquitin/ligase complexes and are involved in a lot of cellular processes in yeasts. However, the current knowledge of the molecular evolution of the F-box gene family in yeasts remains unclear. In this study, 136 F-box genes were identified in 10 yeast species of the Saccharomycetaceae. Read More

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http://dx.doi.org/10.1089/dna.2018.4271DOI Listing
April 2019
2 Reads

Association of the Promoter Methylation and the rs12917 Polymorphism of MGMT with Formation of DNA Bulky Adducts and the Risk of Lung Cancer in Mexican Mestizo Population.

DNA Cell Biol 2019 Apr 20;38(4):307-313. Epub 2019 Feb 20.

3 Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

O-Methylguanine-DNA methyltransferase (MGMT) is an enzyme that repairs the DNA damage caused by the tobacco habit, and low activity of this enzyme has been associated with a risk of lung cancer (LC). Our objective was to determine the association of the promoter methylation and the rs12917 polymorphism of MGMT with formation of DNA bulky adducts and the risk of LC in the Mexican Mestizo population. In this study are included 431 subjects. Read More

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http://dx.doi.org/10.1089/dna.2018.4526DOI Listing
April 2019
2 Reads

Efficient Generation of an Fah/Rag2 Dual-Gene Knockout Porcine Cell Line Using CRISPR/Cas9 and Adenovirus.

DNA Cell Biol 2019 Apr 14;38(4):314-321. Epub 2019 Feb 14.

1 Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHFPC, West China Hospital, Sichuan University, Chengdu, China.

The shortage of human hepatocytes continues to be a significant limitation for the widespread application of hepatocyte transplantation and bioartificial liver (BAL) support therapy. Recombinant activation gene 2 (Rag2) and fumarylacetoacetate hydrolase (Fah)-deficient mice could be highly repopulated with human hepatocytes. However, Fah/Rag2-deficient mice can only produce up to 1 × 10 human hepatocytes per mouse. Read More

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http://dx.doi.org/10.1089/dna.2018.4493DOI Listing
April 2019
2 Reads

Reciprocal Regulation Between O-GlcNAcylation and β-Catenin Facilitates Cell Viability and Inhibits Apoptosis in Liver Cancer.

DNA Cell Biol 2019 Apr 14;38(4):286-296. Epub 2019 Feb 14.

1 Department of Hepatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.

Abnormal expression of O-Linked β-N-acetylglucosamine (O-GlcNAc) and β-catenin is a general feature of cancer and contributes to transformed phenotypes. In this study, we identified the interaction between O-GlcNAc and β-catenin, and explored their effects on the progression of liver cancer. Our results demonstrated that upregulation of O-GlcNAc was induced by high glucose, whereas the application of PuGNAc and GlcNAc increased β-catenin protein expression levels, as well as the protein's stability and nuclear accumulation in the liver cancer cell lines HEP-G2 and HuH-7. Read More

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http://dx.doi.org/10.1089/dna.2018.4447DOI Listing
April 2019
3 Reads

BMP9 Promotes the Extracellular Matrix of Nucleus Pulposus Cells via Inhibition of the Notch Signaling Pathway.

DNA Cell Biol 2019 Apr 13;38(4):358-366. Epub 2019 Feb 13.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Intervertebral disk degeneration (IDD) is a common disease that is caused by degeneration of the nucleus pulposus (NP). One goal in the treatment of IDD is delaying or reversing the degeneration of NP via the transformation of exogenous genes. This study first investigated the role of BMP9 in the extracellular matrix (ECM) of nucleus pulposus cells (NPCs) and its mechanism. Read More

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http://dx.doi.org/10.1089/dna.2018.4478DOI Listing
April 2019
2 Reads

Long Noncoding RNA SNHG16 Promotes Osteosarcoma Cells Migration and Invasion via Sponging miRNA-340.

DNA Cell Biol 2019 Feb;38(2):170-175

2 Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Long noncoding RNA host gene 16 (SNHG16) has a key role in a variety of cancer progression. However, the role and mechanism of SNHG16 in osteosarcoma (OS) remain unknown. In this study, we examined the functional role of SNHG16 in OS cells through knocked-down SNHG16 by using siRNA. Read More

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http://dx.doi.org/10.1089/dna.2018.4424DOI Listing
February 2019

Transcriptome Analysis of Dairy Goat Mammary Gland Tissues from Different Lactation Stages.

DNA Cell Biol 2019 Feb;38(2):129-143

Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian City, Shandong Province, P.R. China.

The mammary gland is a unique organ involved in lactation in dairy livestock, and its development and lactation ability are affected by both genetic and environmental factors. To explore the molecular regulatory mechanisms of these factors, this study used high-throughput sequencing technology and bioinformatics methods to systematically analyze the transcriptome of Laoshan dairy goat mammary gland tissues from different lactation stages. From three libraries, 36,336,892, 36,469,596, and 35,759,380, pure sequences were obtained, with 25,292, 23,665 and 27,220 expressed genes, respectively, resulting in a total of 14,892 nonredundant differentially expressed genes. Read More

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http://dx.doi.org/10.1089/dna.2018.4349DOI Listing
February 2019
2 Reads

Polymorphism in CYP24A1 Is Associated with Lung Cancer Risk: A Case-Control Study in Chinese Female Nonsmokers.

DNA Cell Biol 2019 Mar 6;38(3):243-249. Epub 2019 Feb 6.

1 Department of Epidemiology, School of Public Health, China Medical University, Shenyang, P.R. China.

CYP24A1 plays important roles in antiproliferative effects, which have been proved in many human tumor cells. Polymorphisms in CYP24A1 may affect the risk of lung cancer, but the results remained inconclusive. To enhance the understanding of possible relationship between CYP24A1 polymorphism rs6068816 and lung cancer risks, we first carried out this case-control study among Chinese female nonsmokers, including 345 lung cancer patients and 351 noncancer controls. Read More

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http://dx.doi.org/10.1089/dna.2018.4510DOI Listing

Structural and Functional Plasticity of Collagen Fibrils.

DNA Cell Biol 2019 Apr 6;38(4):367-373. Epub 2019 Feb 6.

1 Department of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.

Collagen is a major component of the subendothelial matrix and participates in bleeding arrest by activating and aggregating platelets at the site of vascular injury. The most common type I collagen exists in both soluble and fibrillar forms, but structural exchangeability between the two forms is currently unknown. Using atomic force microscopy, we show that type I collagen switches between soluble and fibrillar forms in a pH-dependent and ion-independent manner. Read More

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http://dx.doi.org/10.1089/dna.2018.4494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477584PMC
April 2019
3 Reads
2.055 Impact Factor

Long Noncoding RNA LINC00152 Facilitates the Leukemogenesis of Acute Myeloid Leukemia by Promoting CDK9 Through miR-193a.

DNA Cell Biol 2019 Mar 1;38(3):236-242. Epub 2019 Feb 1.

2 General Practice Department, The First Hospital of Jiaxing, Jiaxing, China.

The vital role of long noncoding RNAs (lncRNAs) on the acute myeloid leukemia (AML) has been increasingly recognized. This study aims to explore the unknown function of lncRNA LINC00152 in the leukemogenesis of AML. LINC00152 is determined to be upregulated in the AML samples, and the overexpression of LINC00152 is also authenticated in the advanced French-American-British (FAB) AML patients and closely correlated with the poor outcome of AML patients. Read More

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http://dx.doi.org/10.1089/dna.2018.4482DOI Listing
March 2019
2 Reads

miR-21-3p Targets Elovl5 and Regulates Triglyceride Production in Mammary Epithelial Cells of Cow.

DNA Cell Biol 2019 Apr 1;38(4):352-357. Epub 2019 Feb 1.

1 Department of Animal Science, Jilin University, Changchun, Jilin, P.R. China.

MicroRNAs (miRNAs) can regulate a variety of biological functions such as fat and cholesterol synthesis, translocation, and utilization by regulating degradation or by inhibiting target mRNA translation. In this study, the target gene of miR-21-3p was analyzed through bioinformatics, which predicted Elovl5. Furthermore, miR-21-3p was verified for regulation of triglyceride expression. Read More

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https://www.liebertpub.com/doi/10.1089/dna.2018.4409
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http://dx.doi.org/10.1089/dna.2018.4409DOI Listing
April 2019
1 Read

Negative Effects of Cyclic Palmitate Treatment on Glucose Responsiveness and Insulin Production in Mouse Insulinoma Min6 Cells Are Reversible.

DNA Cell Biol 2019 Apr 31;38(4):395-403. Epub 2019 Jan 31.

4 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

Pancreatic β-cell failure is characterized by compromised insulin secretion in response to glucose, which ultimately results in hyperglycemia, the clinical hallmark of type 2 diabetes mellitus (T2DM). Acute exposure to plasma free fatty acids (FFAs) potentiates glucose stimulated insulin secretion (GSIS), while chronic exposure impairs GSIS, and the latter has been associated with the mechanism of β cell failure in obesity linked T2DM. By contrast, growth hormone (GH) signaling has been linked positively to GSIS in β cells. Read More

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http://dx.doi.org/10.1089/dna.2018.4558DOI Listing
April 2019
3 Reads

Involvement of the Dysregulation of miR-23b-3p, miR-195-5p, miR-656-5p, and miR-340-5p in Trastuzumab Resistance of HER2-Positive Breast Cancer Cells and System Biology Approach to Predict Their Targets Involved in Resistance.

DNA Cell Biol 2019 Feb 31;38(2):184-192. Epub 2019 Jan 31.

2 Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Resistance to trastuzumab has become a limiting factor for therapeutic efficacy of human epidermal growth factor 2 (HER2)-positive breast cancer. Different expression levels of miRNAs in cancer cells have been associated with poor prognosis and response to chemotherapy. The aim of this study was to evaluate miRNAs that were thought to be associated with HER2-positive breast cancer chemoresistance. Read More

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http://dx.doi.org/10.1089/dna.2018.4427DOI Listing
February 2019
3 Reads

Identification of a 26-lncRNAs Risk Model for Predicting Overall Survival of Cervical Squamous Cell Carcinoma Based on Integrated Bioinformatics Analysis.

DNA Cell Biol 2019 Apr 30;38(4):322-332. Epub 2019 Jan 30.

Department of Oncology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China.

As a common malignancy in women, cervical squamous cell carcinoma is a major cause of cancer-related mortality globally. Recent studies have demonstrated that long non-coding RNA (lncRNA) can function as potential biomarkers in cancer prognosis; however, little is known about its role in cervical cancer. In this study, we downloaded the gene expression profiles along with the clinical data of patients with cervical squamous cell carcinoma from The Cancer Genome Atlas. Read More

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http://dx.doi.org/10.1089/dna.2018.4533DOI Listing

lncRNA SRA1 Promotes the Activation of Cardiac Myofibroblasts Through Negative Regulation of miR-148b.

DNA Cell Biol 2019 Apr 29;38(4):385-394. Epub 2019 Jan 29.

Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, China.

Long noncoding RNAs (lncRNAs) have been reported to play a key role in diversity cardiovascular diseases, including cardiac fibrosis. The present study aims to investigate the biological role of lncRNA SRA1 in the activation of cardiac myofibroblasts and the underlying mechanism. Results showed that the expression of SRA1 was upregulated accompanied by cardiac fibrosis in an abdominal aortic banding-treated rat model. Read More

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http://dx.doi.org/10.1089/dna.2018.4358DOI Listing
April 2019
1 Read

Identification and Analysis of a Candidate WRKY Transcription Factor Gene Affecting Adventitious Root Formation Using Association Mapping in Catalpa Scop.

DNA Cell Biol 2019 Apr 24;38(4):297-306. Epub 2019 Jan 24.

Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Research Center of Ornamental Plants, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, China.

The capacity to develop adventitious roots (AR) from cuttings is a key factor for the mass deployment of superior genotypes in the woody plant, including Catalpa Scop. Catalpa Scop. was characterized as having excellent woody qualities in China. Read More

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http://dx.doi.org/10.1089/dna.2018.4528DOI Listing
April 2019
2 Reads

microRNA-Mediated Tumor-Microbiota Metabolic Interactions in Colorectal Cancer.

DNA Cell Biol 2019 Apr 22;38(4):281-285. Epub 2019 Jan 22.

1 Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, Minnesota.

Worldwide, colorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Recent advances in high-throughput technologies have shown that the gut microbiota may have a major influence on human health, including CRC. Nonetheless, how the gut microbiota interacts with tumor cells in CRC patients is largely unknown. Read More

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http://dx.doi.org/10.1089/dna.2018.4579DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477581PMC

Identification of Candidate Genes Involved in Renal Ischemia/Reperfusion Injury.

DNA Cell Biol 2019 Mar 22;38(3):256-262. Epub 2019 Jan 22.

2 Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

Renal ischemia/reperfusion injury (IRI) is a main risk factor for the occurrence of delayed graft function or primary graft nonfunction of kidney transplantation. However, it lacks ideal molecular markers for indicating IRI in kidney transplantation. The present study is to explore novel candidate genes involved in renal IRI. Read More

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http://dx.doi.org/10.1089/dna.2018.4551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434600PMC
March 2019
2 Reads
2.055 Impact Factor

Helicobacter pylori-Induced DNA Damage Is a Potential Driver for Human Gastric Cancer AGS Cells.

DNA Cell Biol 2019 Mar 18;38(3):272-280. Epub 2019 Jan 18.

3 Department of Gastroenterology, Peking University Third Hospital, Beijing, P.R. China.

Helicobacter pylori is a major cause of gastric cancer. This study was aimed to explore the characteristic of DNA damage induced by H. pylori infection in gastric cancer AGS cells. Read More

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http://dx.doi.org/10.1089/dna.2018.4487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434597PMC
March 2019
1 Read
2.055 Impact Factor

Origin of Coding RNA from Random-Sequence RNA.

Authors:
Gaspar Banfalvi

DNA Cell Biol 2019 Mar 14;38(3):223-228. Epub 2019 Jan 14.

Department of Biotechnology and Microbiology, University of Debrecen, Debrecen, Hungary.

D-ribose and D-arabinose differ only by the steric orientation of their C2-OH groups. The initial reactions and emergence of RNA depended on the position, reactivity, and flexibility of the C2-OH moiety in the ribose molecule. The steric relationship of the C2- and C3-OH groups favored the selection of ribose, ribonucleotide, and RNA synthesis and excluded the possibility of xenonucleic acid-based life on Earth. Read More

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http://dx.doi.org/10.1089/dna.2018.4389DOI Listing
March 2019
1 Read

Effects of MDR1 (C3435T) Polymorphism on Resistance, Uptake, and Efflux to Antiepileptic Drugs.

DNA Cell Biol 2019 Mar 11;38(3):250-255. Epub 2019 Jan 11.

Department of Pharmacy, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

P-glycoprotein (P-gp), encoded by the MDR1 (multidrug resistance 1) gene, involves in the efflux of multiple compounds, such as certain antiepileptic drugs. The aim of this research was to observe the impacts of MDR1 (C3435T) variant on the efflux of phenytoin, carbamazepine, valproate, and phenobarbital in vitro. Stable recombinant LLC-PK1 cell systems transfected with MDR1 (wild-type allele) and MDR1 (variant allele) were constructed. Read More

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http://dx.doi.org/10.1089/dna.2018.4553DOI Listing
March 2019
1 Read

Gen1 Modulates Metanephric Morphology Through Retinoic Acid Signaling.

DNA Cell Biol 2019 Mar 11;38(3):263-271. Epub 2019 Jan 11.

1 Department of Nephrology, Children's Hospital of Fudan University, Shanghai Kidney Development and Pediatric Kidney Disease Research Center, Shanghai, China.

Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of end-stage renal disease in children. Our group has discovered that Holliday Junction resolvase gene Gen1 is a potential candidate gene for CAKUT. Gen1 mutant mice showed CAKUT phenotypes similar to those observed in retinoic acid (RA)-deficient models. Read More

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http://dx.doi.org/10.1089/dna.2018.4426DOI Listing
March 2019
2 Reads

Transcriptional Regulation of NAMPT Gene by Glycogen Synthase Kinase 3β in Goat Adipocytes.

DNA Cell Biol 2019 Mar 7;38(3):229-235. Epub 2019 Jan 7.

1 Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, P.R. China.

Nicotinamide phosphoribosyl transferase (NAMPT) is a cytokine which is secreted by adipose tissue and involved in the process of immunoreactions, inflammation, and lipid metabolism through the endocrine or paracrine. However, the information regarding NAMPT and its transcriptional regulation in goats remains unknown. In this study, the inactivation of glycogen synthase kinase 3β (GSK3β) decreased the supernatant NAMPT productions in goat adipocytes. Read More

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https://www.liebertpub.com/doi/10.1089/dna.2018.4499
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http://dx.doi.org/10.1089/dna.2018.4499DOI Listing
March 2019
8 Reads
2.055 Impact Factor

Molecular Mechanism of Externalization of Phosphatidylserine on the Surface of Ebola Virus Particles.

DNA Cell Biol 2019 Feb 7;38(2):115-120. Epub 2019 Jan 7.

2 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Ebola virus (EBOV) is an enveloped filamentous virus that causes severe hemorrhagic fever in humans and nonhuman primates with up to 90% fatality. Accumulating evidence indicates that various viruses, including EBOV, exploit the host apoptotic clearance machinery to enhance their entry into host cells by externalizing phosphatidylserine (PS) in the viral envelope. PS is typically distributed in the inner layer of the plasma membrane (PM) in normal cells. Read More

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https://www.liebertpub.com/doi/10.1089/dna.2018.4485
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http://dx.doi.org/10.1089/dna.2018.4485DOI Listing
February 2019
4 Reads

Long Noncoding RNA LINC00460 Promotes the Gefitinib Resistance of Nonsmall Cell Lung Cancer Through Epidermal Growth Factor Receptor by Sponging miR-769-5p.

DNA Cell Biol 2019 Feb 2;38(2):176-183. Epub 2019 Jan 2.

3 Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

The vital roles of long noncoding RNAs (lncRNAs) in the nonsmall cell lung cancer (NSCLC) tumorigenesis are increasingly important. This work aims to investigate the role of lncRNA LINC00460 in the gefitinib resistance of NSCLC cells and discover its relevant mechanism. Our finding reveals that the expression of lncRNA LINC00460 is upregulated in the gefitinib-resistant NSCLC tissue and cells, and closely correlated with advanced tumor stage and clinical poor prognosis outcome. Read More

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http://dx.doi.org/10.1089/dna.2018.4462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6383575PMC
February 2019
1 Read

miR-142 Suppresses Endometrial Cancer Proliferation In Vitro and In Vivo by Targeting Cyclin D1.

DNA Cell Biol 2019 Feb 26;38(2):144-150. Epub 2018 Dec 26.

4 Department of Physical Examination, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Endometrial cancer (EC), a prevalent gynecologic tumor, is a great threat to women. We aimed to explore miR-142's effects on EC and the relevant mechanisms. Cell proliferation was evaluated with MTT, cell counting, and colony formation assay. Read More

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http://dx.doi.org/10.1089/dna.2018.4441DOI Listing
February 2019
2 Reads

Response to Zhang et al. re:"CXCR5 CD8 T Cells Indirectly Offer B Cell Help and Are Inversely Correlated with Viral Load in Chronic Hepatitis B Infection".

Authors:
Yun Jin

DNA Cell Biol 2019 Jan 21;38(1):113. Epub 2018 Dec 21.

Department of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province , Kuming, China .

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http://dx.doi.org/10.1089/dna.2018.4538DOI Listing
January 2019
1 Read

miRNA-106a Promotes Breast Cancer Cell Proliferation, Clonogenicity, Migration, and Invasion Through Inhibiting Apoptosis and Chemosensitivity.

DNA Cell Biol 2019 Feb 20;38(2):198-207. Epub 2018 Dec 20.

1 Department of Breast/Thyroid Surgery, Shengli Oilfield Central Hospital, Dongying, China.

To explore the effect of miR-106a in breast cancer cell behavior and sensitivity to chemotherapeutic agents. Tumor tissue and adjacent normal tissue were derived from 40 breast cancer patients, and miR-106a expression was measured by reverse transcription-qPCR. Breast cancer cells, MDA-MB-231 and MCF-7, were treated with miRNA-106a mimic (MM) or miRNA-106a inhibitor (MI) and negative controls. Read More

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https://www.liebertpub.com/doi/10.1089/dna.2018.4282
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http://dx.doi.org/10.1089/dna.2018.4282DOI Listing
February 2019
13 Reads

DNA Methylation and Transcription Factors Competitively Regulate SIRT4 Promoter Activity in Bovine Adipocytes: Roles of NRF1 and CMYB.

DNA Cell Biol 2019 Jan 20;38(1):63-75. Epub 2018 Dec 20.

1 College of Animal Science and Technology, Northwest A&F University, Yangling, China.

Sirtuin 4 (SIRT4) belongs to the mitochondrial sirtuin protein family, a class of NAD-dependent protein deacylases that remove post-translational acyl modifications from cellular substrates during the regulation of various biological pathways. SIRT4 has been shown to regulate lipid homeostasis. However, the mechanism by which the bovine SIRT4 gene is transcriptionally regulated remains unknown. Read More

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http://dx.doi.org/10.1089/dna.2018.4454DOI Listing
January 2019
1 Read

Expression and Clinical Significance of CMTM6 in Hepatocellular Carcinoma.

DNA Cell Biol 2019 Feb 18;38(2):193-197. Epub 2018 Dec 18.

1 Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, P.R. China.

This study aimed to examine the expression level and clinical significance of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) in paired hepatocellular carcinoma (HCC) and adjacent nontumor tissues. The expression of CMTM6 was detected in 75 paired HCC and adjacent nontumor tissues by immunohistochemistry. Chi-square test was used to compare the difference of CMTM6 expression between HCC tissues and adjacent nontumor tissues. Read More

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http://dx.doi.org/10.1089/dna.2018.4513DOI Listing
February 2019
3 Reads