3,077 results match your criteria DNA and Cell Biology [Journal]


Association of the Promoter Methylation and the rs12917 Polymorphism of MGMT with Formation of DNA Bulky Adducts and the Risk of Lung Cancer in Mexican Mestizo Population.

DNA Cell Biol 2019 Feb 20. Epub 2019 Feb 20.

3 Departamento de Medicina Genómica y Toxicología Ambiental, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad de México, Mexico.

O-Methylguanine-DNA methyltransferase (MGMT) is an enzyme that repairs the DNA damage caused by the tobacco habit, and low activity of this enzyme has been associated with a risk of lung cancer (LC). Our objective was to determine the association of the promoter methylation and the rs12917 polymorphism of MGMT with formation of DNA bulky adducts and the risk of LC in the Mexican Mestizo population. In this study are included 431 subjects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4526DOI Listing
February 2019

Efficient Generation of an Fah/Rag2 Dual-Gene Knockout Porcine Cell Line Using CRISPR/Cas9 and Adenovirus.

DNA Cell Biol 2019 Feb 14. Epub 2019 Feb 14.

1 Laboratory of Pathology, Key Laboratory of Transplant Engineering and Immunology, NHFPC, West China Hospital, Sichuan University, Chengdu, China.

The shortage of human hepatocytes continues to be a significant limitation for the widespread application of hepatocyte transplantation and bioartificial liver (BAL) support therapy. Recombinant activation gene 2 (Rag2) and fumarylacetoacetate hydrolase (Fah)-deficient mice could be highly repopulated with human hepatocytes. However, Fah/Rag2-deficient mice can only produce up to 1 × 10 human hepatocytes per mouse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4493DOI Listing
February 2019

Reciprocal Regulation Between O-GlcNAcylation and β-Catenin Facilitates Cell Viability and Inhibits Apoptosis in Liver Cancer.

DNA Cell Biol 2019 Feb 14. Epub 2019 Feb 14.

1 Department of Hepatology, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, P.R. China.

Abnormal expression of O-Linked β-N-acetylglucosamine (O-GlcNAc) and β-catenin is a general feature of cancer and contributes to transformed phenotypes. In this study, we identified the interaction between O-GlcNAc and β-catenin, and explored their effects on the progression of liver cancer. Our results demonstrated that upregulation of O-GlcNAc was induced by high glucose, whereas the application of PuGNAc and GlcNAc increased β-catenin protein expression levels, as well as the protein's stability and nuclear accumulation in the liver cancer cell lines HEP-G2 and HuH-7. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4447DOI Listing
February 2019
2 Reads

BMP9 Promotes the Extracellular Matrix of Nucleus Pulposus Cells Via Inhibition of the Notch Signaling Pathway.

DNA Cell Biol 2019 Feb 13. Epub 2019 Feb 13.

Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.

Intervertebral disk degeneration (IDD) is a common disease that is caused by degeneration of the nucleus pulposus (NP). One goal in the treatment of IDD is delaying or reversing the degeneration of NP via the transformation of exogenous genes. This study first investigated the role of BMP9 in the extracellular matrix (ECM) of nucleus pulposus cells (NPCs) and its mechanism. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4478DOI Listing
February 2019

Acknowledgment of Our Reviewers.

Authors:

DNA Cell Biol 2019 Feb 14;38(2):208-218. Epub 2018 Dec 14.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.29009.csrDOI Listing
February 2019

Long Noncoding RNA SNHG16 Promotes Osteosarcoma Cells Migration and Invasion via Sponging miRNA-340.

DNA Cell Biol 2019 Feb;38(2):170-175

2 Department of Orthopedics, Tongji Hospital, Tongji University School of Medicine, Shanghai, China.

Long noncoding RNA host gene 16 (SNHG16) has a key role in a variety of cancer progression. However, the role and mechanism of SNHG16 in osteosarcoma (OS) remain unknown. In this study, we examined the functional role of SNHG16 in OS cells through knocked-down SNHG16 by using siRNA. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4424DOI Listing
February 2019

Transcriptome Analysis of Dairy Goat Mammary Gland Tissues from Different Lactation Stages.

DNA Cell Biol 2019 Feb;38(2):129-143

Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Shandong Agricultural University, Taian City, Shandong Province, P.R. China.

The mammary gland is a unique organ involved in lactation in dairy livestock, and its development and lactation ability are affected by both genetic and environmental factors. To explore the molecular regulatory mechanisms of these factors, this study used high-throughput sequencing technology and bioinformatics methods to systematically analyze the transcriptome of Laoshan dairy goat mammary gland tissues from different lactation stages. From three libraries, 36,336,892, 36,469,596, and 35,759,380, pure sequences were obtained, with 25,292, 23,665 and 27,220 expressed genes, respectively, resulting in a total of 14,892 nonredundant differentially expressed genes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4349DOI Listing
February 2019

Polymorphism in CYP24A1 Is Associated with Lung Cancer Risk: A Case-Control Study in Chinese Female Nonsmokers.

DNA Cell Biol 2019 Feb 6. Epub 2019 Feb 6.

1 Department of Epidemiology, School of Public Health, China Medical University, Shenyang, P.R. China.

CYP24A1 plays important roles in antiproliferative effects, which have been proved in many human tumor cells. Polymorphisms in CYP24A1 may affect the risk of lung cancer, but the results remained inconclusive. To enhance the understanding of possible relationship between CYP24A1 polymorphism rs6068816 and lung cancer risks, we first carried out this case-control study among Chinese female nonsmokers, including 345 lung cancer patients and 351 noncancer controls. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4510DOI Listing
February 2019

Structural and Functional Plasticity of Collagen Fibrils.

DNA Cell Biol 2019 Feb 6. Epub 2019 Feb 6.

1 Department of Neurosurgery, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.

Collagen is a major component of the subendothelial matrix and participates in bleeding arrest by activating and aggregating platelets at the site of vascular injury. The most common type I collagen exists in both soluble and fibrillar forms, but structural exchangeability between the two forms is currently unknown. Using atomic force microscopy, we show that type I collagen switches between soluble and fibrillar forms in a pH-dependent and ion-independent manner. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4494DOI Listing
February 2019
2.055 Impact Factor

Long Noncoding RNA LINC00152 Facilitates the Leukemogenesis of Acute Myeloid Leukemia by Promoting CDK9 Through miR-193a.

DNA Cell Biol 2019 Feb 1. Epub 2019 Feb 1.

2 General Practice Department, The First Hospital of Jiaxing, Jiaxing, China.

The vital role of long noncoding RNAs (lncRNAs) on the acute myeloid leukemia (AML) has been increasingly recognized. This study aims to explore the unknown function of lncRNA LINC00152 in the leukemogenesis of AML. LINC00152 is determined to be upregulated in the AML samples, and the overexpression of LINC00152 is also authenticated in the advanced French-American-British (FAB) AML patients and closely correlated with the poor outcome of AML patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4482DOI Listing
February 2019
2 Reads

miR-21-3p Targets Elovl5 and Regulates Triglyceride Production in Mammary Epithelial Cells of Cow.

DNA Cell Biol 2019 Feb 1. Epub 2019 Feb 1.

1 Department of Animal Science, Jilin University, Changchun, Jilin, P. R. China.

MicroRNAs (miRNAs) can regulate a variety of biological functions such as fat and cholesterol synthesis, translocation, and utilization by regulating degradation or by inhibiting target mRNA translation. In this study, the target gene of miR-21-3p was analyzed through bioinformatics, which predicted Elovl5. Furthermore, miR-21-3p was verified for regulation of triglyceride expression. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4409
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4409DOI Listing
February 2019
1 Read

Negative Effects of Cyclic Palmitate Treatment on Glucose Responsiveness and Insulin Production in Mouse Insulinoma Min6 Cells Are Reversible.

DNA Cell Biol 2019 Jan 31. Epub 2019 Jan 31.

4 Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas.

Pancreatic β-cell failure is characterized by compromised insulin secretion in response to glucose, which ultimately results in hyperglycemia, the clinical hallmark of type 2 diabetes mellitus (T2DM). Acute exposure to plasma free fatty acids (FFAs) potentiates glucose stimulated insulin secretion (GSIS), while chronic exposure impairs GSIS, and the latter has been associated with the mechanism of β cell failure in obesity linked T2DM. By contrast, growth hormone (GH) signaling has been linked positively to GSIS in β cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4558DOI Listing
January 2019
1 Read

Involvement of the Dysregulation of miR-23b-3p, miR-195-5p, miR-656-5p, and miR-340-5p in Trastuzumab Resistance of HER2-Positive Breast Cancer Cells and System Biology Approach to Predict Their Targets Involved in Resistance.

DNA Cell Biol 2019 Feb 31;38(2):184-192. Epub 2019 Jan 31.

2 Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.

Resistance to trastuzumab has become a limiting factor for therapeutic efficacy of human epidermal growth factor 2 (HER2)-positive breast cancer. Different expression levels of miRNAs in cancer cells have been associated with poor prognosis and response to chemotherapy. The aim of this study was to evaluate miRNAs that were thought to be associated with HER2-positive breast cancer chemoresistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4427DOI Listing
February 2019
2 Reads

Identification of a 26-lncRNAs Risk Model for Predicting Overall Survival of Cervical Squamous Cell Carcinoma Based on Integrated Bioinformatics Analysis.

DNA Cell Biol 2019 Jan 30. Epub 2019 Jan 30.

Department of Oncology, First Hospital of Qinhuangdao, Qinhuangdao, Hebei, China.

As a common malignancy in women, cervical squamous cell carcinoma is a major cause of cancer-related mortality globally. Recent studies have demonstrated that long non-coding RNA (lncRNA) can function as potential biomarkers in cancer prognosis; however, little is known about its role in cervical cancer. In this study, we downloaded the gene expression profiles along with the clinical data of patients with cervical squamous cell carcinoma from The Cancer Genome Atlas. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4533DOI Listing
January 2019

lncRNA SRA1 Promotes the Activation of Cardiac Myofibroblasts Through Negative Regulation of miR-148b.

DNA Cell Biol 2019 Jan 29. Epub 2019 Jan 29.

Department of Anesthesiology, Lanzhou University Second Hospital, Lanzhou, China.

Long noncoding RNAs (lncRNAs) have been reported to play a key role in diversity cardiovascular diseases, including cardiac fibrosis. The present study aims to investigate the biological role of lncRNA SRA1 in the activation of cardiac myofibroblasts and the underlying mechanism. Results showed that the expression of SRA1 was upregulated accompanied by cardiac fibrosis in an abdominal aortic banding-treated rat model. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4358DOI Listing
January 2019
1 Read

Identification and Analysis of a Candidate WRKY Transcription Factor Gene Affecting Adventitious Root Formation Using Association Mapping in Catalpa Scop.

DNA Cell Biol 2019 Jan 24. Epub 2019 Jan 24.

Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Research Center of Ornamental Plants, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences, Nanjing, China.

The capacity to develop adventitious roots (AR) from cuttings is a key factor for the mass deployment of superior genotypes in the woody plant, including Catalpa Scop. Catalpa Scop. was characterized as having excellent woody qualities in China. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4528DOI Listing
January 2019

MicroRNA-Mediated Tumor-Microbiota Metabolic Interactions in Colorectal Cancer.

DNA Cell Biol 2019 Jan 22. Epub 2019 Jan 22.

1 Bioinformatics and Computational Biology Program, University of Minnesota, Minneapolis, Minnesota.

Worldwide, colorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Recent advances in high-throughput technologies have shown that the gut microbiota may have a major influence on human health, including CRC. Nonetheless, how the gut microbiota interacts with tumor cells in CRC patients is largely unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4579DOI Listing
January 2019

Identification of Candidate Genes Involved in Renal Ischemia/Reperfusion Injury.

DNA Cell Biol 2019 Jan 22. Epub 2019 Jan 22.

2 Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, People's Republic of China.

Renal ischemia/reperfusion injury (IRI) is a main risk factor for the occurrence of delayed graft function or primary graft nonfunction of kidney transplantation. However, it lacks ideal molecular markers for indicating IRI in kidney transplantation. The present study is to explore novel candidate genes involved in renal IRI. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4551DOI Listing
January 2019
2.055 Impact Factor

Helicobacter pylori-Induced DNA Damage Is a Potential Driver for Human Gastric Cancer AGS Cells.

DNA Cell Biol 2019 Jan 18. Epub 2019 Jan 18.

3 Department of Gastroenterology, Peking University Third Hospital, Beijing, P.R. China.

Helicobacter pylori is a major cause of gastric cancer. This study was aimed to explore the characteristic of DNA damage induced by H. pylori infection in gastric cancer AGS cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4487DOI Listing
January 2019
1 Read
2.055 Impact Factor

Origin of Coding RNA from Random-Sequence RNA.

Authors:
Gaspar Banfalvi

DNA Cell Biol 2019 Jan 14. Epub 2019 Jan 14.

Department of Biotechnology and Microbiology, University of Debrecen, Debrecen, Hungary.

D-ribose and D-arabinose differ only by the steric orientation of their C2-OH groups. The initial reactions and emergence of RNA depended on the position, reactivity, and flexibility of the C2-OH moiety in the ribose molecule. The steric relationship of the C2- and C3-OH groups favored the selection of ribose, ribonucleotide, and RNA synthesis and excluded the possibility of xenonucleic acid-based life on Earth. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4389DOI Listing
January 2019
1 Read

Effects of MDR1 (C3435T) Polymorphism on Resistance, Uptake, and Efflux to Antiepileptic Drugs.

DNA Cell Biol 2019 Jan 11. Epub 2019 Jan 11.

Department of Pharmacy, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.

P-glycoprotein (P-gp), encoded by the MDR1 (multidrug resistance 1) gene, involves in the efflux of multiple compounds, such as certain antiepileptic drugs. The aim of this research was to observe the impacts of MDR1 (C3435T) variant on the efflux of phenytoin, carbamazepine, valproate, and phenobarbital in vitro. Stable recombinant LLC-PK1 cell systems transfected with MDR1 (wild-type allele) and MDR1 (variant allele) were constructed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4553DOI Listing
January 2019
1 Read

Gen1 Modulates Metanephric Morphology Through Retinoic Acid Signaling.

DNA Cell Biol 2019 Jan 11. Epub 2019 Jan 11.

1 Department of Nephrology, Children's Hospital of Fudan University, Shanghai Kidney Development and Pediatric Kidney Disease Research Center, Shanghai, China.

Congenital anomalies of the kidney and urinary tract (CAKUT) are the leading cause of end-stage renal disease in children. Our group has discovered that Holliday Junction resolvase gene Gen1 is a potential candidate gene for CAKUT. Gen1 mutant mice showed CAKUT phenotypes similar to those observed in retinoic acid (RA)-deficient models. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4426DOI Listing
January 2019
1 Read

Transcriptional Regulation of NAMPT Gene by Glycogen Synthase Kinase 3β in Goat Adipocytes.

DNA Cell Biol 2019 Jan 7. Epub 2019 Jan 7.

1 Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu, P.R. China.

Nicotinamide phosphoribosyl transferase (NAMPT) is a cytokine which is secreted by adipose tissue and involved in the process of immunoreactions, inflammation, and lipid metabolism through the endocrine or paracrine. However, the information regarding NAMPT and its transcriptional regulation in goats remains unknown. In this study, the inactivation of glycogen synthase kinase 3β (GSK3β) decreased the supernatant NAMPT productions in goat adipocytes. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4499
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4499DOI Listing
January 2019
8 Reads
2.055 Impact Factor

Molecular Mechanism of Externalization of Phosphatidylserine on the Surface of Ebola Virus Particles.

DNA Cell Biol 2019 Feb 7;38(2):115-120. Epub 2019 Jan 7.

2 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Ebola virus (EBOV) is an enveloped filamentous virus that causes severe hemorrhagic fever in humans and nonhuman primates with up to 90% fatality. Accumulating evidence indicates that various viruses, including EBOV, exploit the host apoptotic clearance machinery to enhance their entry into host cells by externalizing phosphatidylserine (PS) in the viral envelope. PS is typically distributed in the inner layer of the plasma membrane (PM) in normal cells. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4485
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4485DOI Listing
February 2019
2 Reads

Long Noncoding RNA LINC00460 Promotes the Gefitinib Resistance of Nonsmall Cell Lung Cancer Through Epidermal Growth Factor Receptor by Sponging miR-769-5p.

DNA Cell Biol 2019 Feb 2;38(2):176-183. Epub 2019 Jan 2.

3 Department of Radiation Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.

The vital roles of long noncoding RNAs (lncRNAs) in the nonsmall cell lung cancer (NSCLC) tumorigenesis are increasingly important. This work aims to investigate the role of lncRNA LINC00460 in the gefitinib resistance of NSCLC cells and discover its relevant mechanism. Our finding reveals that the expression of lncRNA LINC00460 is upregulated in the gefitinib-resistant NSCLC tissue and cells, and closely correlated with advanced tumor stage and clinical poor prognosis outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4462DOI Listing
February 2019
1 Read

miR-142 Suppresses Endometrial Cancer Proliferation In Vitro and In Vivo by Targeting Cyclin D1.

DNA Cell Biol 2019 Feb 26;38(2):144-150. Epub 2018 Dec 26.

4 Department of Physical Examination, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China.

Endometrial cancer (EC), a prevalent gynecologic tumor, is a great threat to women. We aimed to explore miR-142's effects on EC and the relevant mechanisms. Cell proliferation was evaluated with MTT, cell counting, and colony formation assay. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4441DOI Listing
February 2019
2 Reads

Response to Zhang et al. re:"CXCR5 CD8 T Cells Indirectly Offer B Cell Help and Are Inversely Correlated with Viral Load in Chronic Hepatitis B Infection".

Authors:
Yun Jin

DNA Cell Biol 2019 Jan 21;38(1):113. Epub 2018 Dec 21.

Department of Hepatobiliary Surgery, The First People's Hospital of Yunnan Province , Kuming, China .

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4538DOI Listing
January 2019
1 Read

miRNA-106a Promotes Breast Cancer Cell Proliferation, Clonogenicity, Migration, and Invasion Through Inhibiting Apoptosis and Chemosensitivity.

DNA Cell Biol 2019 Feb 20;38(2):198-207. Epub 2018 Dec 20.

1 Department of Breast/Thyroid Surgery, Shengli Oilfield Central Hospital, Dongying, China.

To explore the effect of miR-106a in breast cancer cell behavior and sensitivity to chemotherapeutic agents. Tumor tissue and adjacent normal tissue were derived from 40 breast cancer patients, and miR-106a expression was measured by reverse transcription-qPCR. Breast cancer cells, MDA-MB-231 and MCF-7, were treated with miRNA-106a mimic (MM) or miRNA-106a inhibitor (MI) and negative controls. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4282
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4282DOI Listing
February 2019
10 Reads

DNA Methylation and Transcription Factors Competitively Regulate SIRT4 Promoter Activity in Bovine Adipocytes: Roles of NRF1 and CMYB.

DNA Cell Biol 2019 Jan 20;38(1):63-75. Epub 2018 Dec 20.

1 College of Animal Science and Technology, Northwest A&F University, Yangling, China.

Sirtuin 4 (SIRT4) belongs to the mitochondrial sirtuin protein family, a class of NAD-dependent protein deacylases that remove post-translational acyl modifications from cellular substrates during the regulation of various biological pathways. SIRT4 has been shown to regulate lipid homeostasis. However, the mechanism by which the bovine SIRT4 gene is transcriptionally regulated remains unknown. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4454DOI Listing
January 2019
1 Read

Expression and Clinical Significance of CMTM6 in Hepatocellular Carcinoma.

DNA Cell Biol 2019 Feb 18;38(2):193-197. Epub 2018 Dec 18.

1 Department of Epidemiology and Statistics, School of Public Health, Guilin Medical University, Guilin, P.R. China.

This study aimed to examine the expression level and clinical significance of chemokine-like factor-like MARVEL transmembrane domain-containing family member 6 (CMTM6) in paired hepatocellular carcinoma (HCC) and adjacent nontumor tissues. The expression of CMTM6 was detected in 75 paired HCC and adjacent nontumor tissues by immunohistochemistry. Chi-square test was used to compare the difference of CMTM6 expression between HCC tissues and adjacent nontumor tissues. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4513DOI Listing
February 2019
2 Reads

Molecular Regulation Mechanisms and Interactions Between Reactive Oxygen Species and Mitophagy.

DNA Cell Biol 2019 Jan 15;38(1):10-22. Epub 2018 Dec 15.

1 Department of Spine Center, Zhongda Hospital, Medical School, Southeast University , Nanjing, Jiangsu, China .

The generation of reactive oxygen species (ROS) in response to oxidative stress has important effects on cell development, normal function, and survival. It may cause oxidative damage to intracellular macromolecular substances and mitochondria through several signaling pathways. However, the damaged mitochondria promote further ROS generation, creating a vicious cycle that can cause cellular injury. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4348
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4348DOI Listing
January 2019
21 Reads

PD-1 Polymorphisms Are Associated with Susceptibility of Acute Anterior Uveitis in Chinese Population.

DNA Cell Biol 2019 Feb 12;38(2):121-128. Epub 2018 Dec 12.

1 The Eye Hospital of Wenzhou Medical University, School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China.

Acute anterior uveitis (AAU) is an ordinary type of uveitis, which is an autoimmune disease produced by T cells. Programmed apoptosis protein 1 (PD-1) is a vital negative regulatory protein of immune tolerance. We detect the single nucleotide polymorphisms (SNPs) rs41386349, rs10204525, and rs2227982 of PD-1 to investigate the correlation between PD-1 polymorphisms and AAU. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4417DOI Listing
February 2019
1 Read

Effects of A94T and P84L Polymorphisms Within the TNF-α Gene on Proliferation and Activation of Hepatic Stellate Cells.

DNA Cell Biol 2019 Feb 18;38(2):162-169. Epub 2018 Dec 18.

Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, Hubei, P.R. China.

Tumor necrosis factor alpha (TNF-α) appears to play an important role in proliferation and activation of hepatic stellate cells (HSCs), but it is unclear whether single nucleotide polymorphisms (SNPs) in the TNF-α gene influence HSCs function. In this study, we explored the effects of TNF-α A94T and P84L polymorphisms on the level of TNF-α, proliferation and activation of HSCs. It was found that A94T and P84L SNPs of TNF-α downregulated the mRNA and protein level of TNF-α in recombinant cells. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4452DOI Listing
February 2019
2 Reads
2.055 Impact Factor

Association of Genetic Variants of NLRP4 with Exacerbation of Asthma: The Effect of Smoking.

DNA Cell Biol 2019 Jan 8;38(1):76-84. Epub 2018 Dec 8.

5 Department of Interdisciplinary Program in Biomedical Science Major, Graduate School, Soonchunhyang University , Bucheon, Korea.

Asthma exacerbation is induced by the interaction of genes and environmental factors such as cigarette smoke. NLRP4 counteracts the activity of the inflammasome, which is responsible for asthma exacerbation. In this study, we analyzed the association of single-nucleotide polymorphisms of NLRP4 with the annual rate of exacerbation and evaluated the additive effect of smoking in 1454 asthmatics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4433DOI Listing
January 2019
1 Read

Novel-miR-4885 Promotes Migration and Invasion of Esophageal Cancer Cells Through Targeting CTNNA2.

DNA Cell Biol 2019 Feb 8;38(2):151-161. Epub 2018 Dec 8.

1 Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, Jiangsu, P.R. China.

Esophageal cancer is one of the most common cancers worldwide. It is critical to find early diagnostic biomarkers for esophageal cancer. MicroRNAs (miRNAs) play important regulatory roles in occurrence and development of esophageal cancer, which has the diagnostic and prognostic values. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4377DOI Listing
February 2019
2 Reads

Retracted: Long Noncoding RNA SOX2OT Accelerates the Carcinogenesis of Wilms' Tumor Through ceRNA Through miR-363/FOXP4 Axis.

DNA Cell Biol 2018 11 27. Epub 2018 Nov 27.

Department of Pediatrics, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University , Huaian, China .

References: ATCC. www.lgcstandards-atcc. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4420DOI Listing
November 2018
2 Reads

Underappreciated Roles of the Translocase of the Outer and Inner Mitochondrial Membrane Protein Complexes in Human Disease.

DNA Cell Biol 2019 Jan 27;38(1):23-40. Epub 2018 Nov 27.

Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University , Cape Town, South Africa .

Mitochondria are critical for cellular survival, and for their proper functioning, translocation of ∼1500 proteins across the mitochondrial membranes is required. The translocase of the outer (TOMM) and inner mitochondrial membrane (TIMM) complexes are major components of this translocation machinery. Through specific processes, preproteins and other molecules are imported, translocated, and directed to specific mitochondrial compartments for their function. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4292DOI Listing
January 2019
2 Reads

DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage.

DNA Cell Biol 2019 Jan 27;38(1):1-6. Epub 2018 Nov 27.

Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Canada .

A new hypothesis for the mechanism of Huntington's disease (HD) is driven by a small molecule lead that may connect age-associated reactive oxygen stress, oxidative DNA damage, and mitochondrial dysfunction. These pathways have also recently been defined in genome-wide association studies of cytosine-adenine-guanine-expansion polyglutamine neurodegenerative diseases, including HD and the spinocerebellar ataxias. We discuss how N6-furfuryladenine (N6FFA) nucleotide salvage and role as a kinase neosubstrate may have important mechanistic implications for both HD and familial Parkinson's disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4476DOI Listing
January 2019
10 Reads

Functional BCL-2 rs2279115 Promoter Noncoding Variant Contributes to Glioma Predisposition, Especially in Males.

DNA Cell Biol 2019 Jan 27;38(1):85-90. Epub 2018 Nov 27.

3 Shandong Provincial Key Laboratory of Radiation Oncology, Cancer Research Center, Shandong Cancer Hospital Affiliated to Shandong University , Shandong Academy of Medical Sciences, Jinan, China .

As a crucial oncogene, B cell lymphoma-2 (BCL-2) could promote cancer cell survival by inhibiting apoptosis via suppressing activation of proapoptotic proteins, such as BAX and BAK. There is a functional rs2279115 genetic polymorphism locating in BCL-2 promoter and deregulating BCL-2 expression. However, it is still largely undefined how BCL-2 rs2279115 promoter noncoding genetic variant is involved in glioma development. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4318
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4318DOI Listing
January 2019
18 Reads

Dual Role of a C-Terminally Truncated Isoform of Large Tumor Suppressor Kinase 1 in the Regulation of Hippo Signaling and Tissue Growth.

DNA Cell Biol 2019 Jan 21;38(1):91-106. Epub 2018 Nov 21.

1 Intercollege Graduate Degree Program in Molecular, Cellular, and Integrative Biosciences, The Pennsylvania State University, University Park , Pennsylvania.

The considerable amount of experimental evidence has defined the Hippo pathway as a tumor suppressive pathway and increased expression and/or activity of its oncogenic effectors is frequently observed in cancer. However, clinical studies have failed to attribute cancer development and progression to mutations in the pathway. In explaining this conundrum, we investigated the expression and functions of a C-terminally truncated isoform of large tumor suppressor kinase 1 (LATS1) called short LATS1 (sLATS1) in human cell lines and Drosophila. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/dna.2018.4340DOI Listing
January 2019
10 Reads

Turned Inside Out: Will Myelin-Protective Therapies Become the Next-Generation Anti-Inflammatories?

DNA Cell Biol 2018 Nov 21. Epub 2018 Nov 21.

Department of Clinical Neurosciences, Hotchkiss Brain Institute, University of Calgary , Calgary, Canada .

The earliest and most proximal triggers of inflammatory demyelination in multiple sclerosis (MS) remain an open question. In this DNACB review we address experimental and clinical evidence consistent with subtle perturbations of the axo-myelinic compartment of central nervous system white matter as initiation sites of secondary autoimmune demyelination in MS. Strengthened by experimental evidence that by inhibiting myelinopathy one can prevent inflammatory demyelination, myelin-protective therapies may represent a new class of anti-inflammatory medications for combating myelin autoimmunity. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4496
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4496DOI Listing
November 2018
2 Reads

Re: "CXCR5 CD8 T Cells Indirectly Offer B Cell Help and Are Inversely Correlated with Viral Load in Chronic Hepatitis B Infection" by Jiang et al. (DNA Cell Biol 2017;36, 321-327).

DNA Cell Biol 2019 Jan 14;38(1):107-112. Epub 2018 Nov 14.

2 Department of Clinical Laboratory, Zhejiang Provincial People's Hospital, People's Hospital of Hangzhou Medical College , Hangzhou, China .

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4278
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4278DOI Listing
January 2019
10 Reads

Consumer Antimicrobials on Gut Microbiota and Gut Health.

DNA Cell Biol 2019 Jan 14;38(1):7-9. Epub 2018 Nov 14.

1 Department of Food Science and University of Massachusetts , Amherst, Massachusetts.

Triclosan (TCS) is a high-volume chemical used as an antimicrobial ingredient in over 2000 consumer products such as toothpastes, cosmetics, and toys. Due to its widespread use, it causes ubiquitous contamination in the environment and is frequently detected in the human body, raising concerns about its impact on environmental pollution and human health. Our recent study showed that short-time exposure to low-dose TCS causes colonic inflammation, increases severity of colitis, and exacerbates colitis-associated colon tumorigenesis in mice, through gut microbiota- and Toll-like receptor 4 (TLR4)-dependent mechanisms. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4483
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350052PMC
January 2019
12 Reads

miR-196a Promotes Proliferation and Inhibits Apoptosis of Immature Porcine Sertoli Cells.

DNA Cell Biol 2019 Jan 14;38(1):41-48. Epub 2018 Nov 14.

1 College of Animal Science, Jilin University , Changchun, Jilin, P.R. China .

Our previous study showed that the expression of miR-196a was significantly higher in immature porcine testes than in mature porcine testes. However, the role of miR-196a in immature Sertoli cells remains unclear. In this study, miR-196a mimics, miR-196a inhibitor, and microRNA-small hairpin negative control (miRNA-ShNC) were transfected into immature Sertoli cells, respectively. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4387
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4387DOI Listing
January 2019
12 Reads

Liraglutide Promotes the Osteogenic Differentiation in MC3T3-E1 Cells Via Regulating the Expression of Smad2/3 Through PI3K/Akt and Wnt/β-Catenin Pathways.

DNA Cell Biol 2018 Nov 7. Epub 2018 Nov 7.

1 Department of Endocrinology, The Third Hospital of Hebei Medical University , Shijiazhuang, Hebei, China .

Diabetes is a worldwide health problem with increasing prevalence. Some reports indicate the interplay between bone and glucose metabolism. The imbalance between bone resorption and formation resulted in the structural integrity and strength of bone. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4397
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4397DOI Listing
November 2018
8 Reads

Biology of Tumor Associated Macrophages in Diffuse Large B Cell Lymphoma.

DNA Cell Biol 2018 Nov 16. Epub 2018 Nov 16.

Department of Hematology, Nanfang Hospital, Southern Medical University , Guangzhou, China .

The tumor associated microenvironment is known to play a vital role during the development and progression of different malignant tumors. As a part of tumor microenvironment, tumor associated macrophages (TAMs) are crucial for the genesis, proliferation, metastasis, and survival of tumor cells. Recently, more and more studies showed that TAMs were related with poor clinical status and survival in patients with diffuse large B cell lymphoma (DLBCL). Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4374
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4374DOI Listing
November 2018
9 Reads

Characterization of MDPL Fibroblasts Carrying the Recurrent p.Ser605del Mutation in POLD1 Gene.

DNA Cell Biol 2018 Nov 2. Epub 2018 Nov 2.

2 Laboratory of Medical Genetics, Tor Vergata Hospital , Rome, Italy .

Mandibular hypoplasia, deafness, and progeroid features, with concomitant lipodystrophy, define a multisystem disorder named MDPL syndrome. MDPL has been associated with heterozygous mutations in POLD1 gene resulting in loss of DNA polymerase δ activity. In this study, we report clinical, genetic, and cellular studies of a 13-year-old Pakistani girl, presenting growth retardation, sensorineural deafness, altered distribution of subcutaneous adipose tissue, and insulin resistance. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4335
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4335DOI Listing
November 2018
15 Reads

Circular RNA hsa_circ_0074362 Promotes Glioma Cell Proliferation, Migration, and Invasion by Attenuating the Inhibition of miR-1236-3p on HOXB7 Expression.

DNA Cell Biol 2018 Nov 2;37(11):917-924. Epub 2018 Nov 2.

1 Department of Neurosurgery, The Fourth Hospital of Harbin Medical University , Harbin, China .

As a novel type of noncoding RNAs, circular RNAs (circRNAs) have been acknowledged as pivot effectors in multiple physiological and pathological processes, including cancer. Although an increasing number of circRNAs are gradually discovered, their function and mechanism in tumorigenesis remain largely unknown. In this study, we identified hsa_circ_0074362 as an oncogene in glioma. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4311
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4311DOI Listing
November 2018
7 Reads

Discovery of Key Genes in Dermatomyositis Based on the Gene Expression Omnibus Database.

DNA Cell Biol 2018 Oct 31. Epub 2018 Oct 31.

1 Rheumatology Department, Xiangya Hospital, Central South University , Changsha, China .

The aim of this study was to identify biomarkers of dermatomyositis (DM). The analysis was conducted by retrieving DM-related cDNA microarray data sets from public databases. Gene ontology, Kyoto encyclopedia of genes and genomes, and protein-protein interaction analyses were performed, together with quantitative PCR-based detection of biomarkers in muscle tissue after stimulation with serum from patients with DM or healthy controls. Read More

View Article

Download full-text PDF

Source
https://www.liebertpub.com/doi/10.1089/dna.2018.4256
Publisher Site
http://dx.doi.org/10.1089/dna.2018.4256DOI Listing
October 2018
11 Reads