43,371 results match your criteria Cytopathology [Journal]


Lymph node fine-needle cytology in the era of personalized medicine. Is there a role?

Cytopathology 2019 Apr 20. Epub 2019 Apr 20.

Universita degli Studi di Salerno, Medicine and Surgery, Fisciano, Campania, IT.

The 2016 WHO revised classification of lymphoma has sub-classified well defined entities and added a number of provisional entities on the basis of new knowledge on genetic, epigenetics and phenotypical data; prognostic and predictive features are also part of this classification. New knowledge on well-defined entities further enlightens the mechanisms of lymphomagenesis, which are more complex and multifactorial than once believed. Therapies are also more complex because traditional clinical trials have been integrated with new drugs and compounds with unique mechanisms of actions against distinct molecular targets. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cyt.12708
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http://dx.doi.org/10.1111/cyt.12708DOI Listing
April 2019
1 Read

Erratum.

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Cancer 2019 May 5;125(9):1571. Epub 2018 Nov 5.

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http://dx.doi.org/10.1002/cncr.31703DOI Listing

Inotuzumab ozogamicin in combination with low-intensity chemotherapy (mini-HCVD) with or without blinatumomab versus standard intensive chemotherapy (HCVAD) as frontline therapy for older patients with Philadelphia chromosome-negative acute lymphoblastic leukemia: A propensity score analysis.

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: The outcome of older patients with newly diagnosed, Philadelphia chromosome (Ph)-negative acute lymphoblastic leukemia (ALL) is poor. The combination of targeted therapy with low-intensity chemotherapy is safe and effective. The objective of the current analysis was to compare the outcome of patients who received a combination of inotuzumab ozogamicin plus low-intensity chemotherapy (mini-hyperfractionated cyclophosphamide, vincristine, and dexamethasone [mini-HCVD]) with or without blinatumomab versus the outcome of those who received the standard, intensive, hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone (HCVAD) regimen. Read More

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http://dx.doi.org/10.1002/cncr.32139DOI Listing
April 2019
1 Read
4.889 Impact Factor

Work-related medical rehabilitation in patients with cancer-Postrehabilitation results from a cluster-randomized multicenter trial.

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Institute for Social Medicine and Epidemiology, University of Lubeck, Lubeck, Germany.

Background: Effective multidisciplinary rehabilitation programs supporting the return to work have become increasingly relevant for cancer survivors. In Germany, inpatient work-related medical rehabilitation programs consider treatment modules of work-related diagnostics, work-related functional capacity training, psychosocial groups, and intensified social counseling. The authors tested the effectiveness of a work-related medical rehabilitation program compared with conventional medical rehabilitation using a cluster-randomized multicenter trial (German Clinical Trial Register: DRKS00007770). Read More

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http://dx.doi.org/10.1002/cncr.32131DOI Listing

Is there still a role for stem cell transplantation in multiple myeloma?

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

High-dose chemotherapy and autologous stem cell transplantation (ASCT) are a standard of care for transplant-eligible patients with newly diagnosed multiple myeloma (MM). The introduction of novel agents, which range from immunomodulatory drugs and proteasome inhibitors to monoclonal antibodies and have now been integrated into both induction and salvage regimens, has dramatically revolutionized the treatment landscape of MM and challenged the role of high-dose chemotherapy and ASCT in treating MM. These advances have led to a number of provocative questions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32060
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http://dx.doi.org/10.1002/cncr.32060DOI Listing
April 2019
2 Reads

Pathfinders in oncology from the end of the 19th century to the first description of Ewing sarcoma.

Authors:
Steven I Hajdu

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Pathology Consultants, Westlake Village, California.

During the period 1884 to 1922, the only option in cases of operable cancers was radical surgery, and only a minority of patients were cured. Sporadic attempts were made to treat inoperable cancer patients with bacterial toxins; however, with the discovery of x-ray and radium, the era of radiation treatment as an alternative to surgery began. The discovery of transmissible cancers and experimental growth of cancer cells offered new information and not only led to a better understanding of the cellular composition of cancers but also yielded important information that ultimately paved the way to chemotherapy. Read More

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http://dx.doi.org/10.1002/cncr.32086DOI Listing

Ambulatory status after surgical and nonsurgical treatment for spinal metastasis.

Cancer 2019 Apr 15. Epub 2019 Apr 15.

Department of Orthopaedic Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

Background: Decisions for operative or nonoperative management remain challenging for patients with spinal metastases, especially when life expectancy and quality of life are not easily predicted. This study evaluated the effects of operative and nonoperative management on maintenance of ambulatory function and survival for patients treated for spinal metastases.

Methods: Propensity matching was used to yield an analytic sample in which operatively and nonoperatively treated patients were similar with respect to key baseline covariates. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32140
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http://dx.doi.org/10.1002/cncr.32140DOI Listing
April 2019
2 Reads

Investigation of lymphoid lesions of the Head and Neck using combined fine needle aspiration cytology and flow cytometry: accuracy and pitfalls.

Cytopathology 2019 Apr 15. Epub 2019 Apr 15.

Cytology Department, Sullivan Nicolaides Pathology, 24 Hurworth St, Bowen Hills, 4006.

Objective: We reviewed the diagnostic utility of combined fine needle aspiration cytology (FNAC) and flow cytometry (FC) in the diagnosis of lymphoid lesions of the head and neck.

Method: 1402 patients with combined FNAC-FC reports were correlated with follow-up information. Rapid on-site evaluation (ROSE) of cytological specimens was performed in 52% of cases. Read More

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http://dx.doi.org/10.1111/cyt.12706DOI Listing
April 2019
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The accuracy of diagnosing Burkitt lymphoma in serous effusion specimen: a cytological-histological correlation with ancillary studies.

Cytopathology 2019 Apr 15. Epub 2019 Apr 15.

Department of pathology, West China Hospital of Sichuan University, Chengdu, 610041, China.

Objective: The objective of this study is to evaluate the effectiveness of diagnosing Burkitt lymphoma (BL) in serous effusion (SE) specimen and summarize the characteristics of BL in SE. We also assess the utility of a germinal centre-associated marker, LMO2, in the differential diagnosis of BL in SE specimen.

Methods: Eleven cases of malignant SE caused by BL were reviewed. Read More

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http://dx.doi.org/10.1111/cyt.12707DOI Listing
April 2019
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Metastatic malignant melanoma to the esophagus, first case diagnosed by endoscopic ultrasound (EUS) guided fine needle aspiration (FNA).

Cytopathology 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathology& laboratory Medicine, Henry Ford Hospital.

Metastatic malignant melanoma to the esophagus is extremely rare. An extensive literature search revealed only 17 reports since 1895. All were diagnosed on surgical specimens. Read More

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http://dx.doi.org/10.1111/cyt.12704DOI Listing

Fixed smears are better than unfixed smears of Fine Needle Aspiration Cytology for detection of Acid-Fast Bacilli on Ziehl-Neelsen Stain.

Authors:
Anju Khairwa

Cytopathology 2019 Apr 13. Epub 2019 Apr 13.

Department of Pathology, ESIC Model Hospital Gurugram, Haryana, India.

Tuberculosis (TB) is an ongoing global health problem. There is still major obstacle in detection of TB despite availability of various diagnostic techniques. The fine needle aspirate cytology (FNAC) had better sensitivity and specificity in the evaluation of tubercular lymphadenitis (TBL) in comparison to conventional lymph node biopsy. Read More

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http://dx.doi.org/10.1111/cyt.12702DOI Listing

Diagnostic challenge in a metastatic pulmonary adenocarcinoma with neuroendocrine differentiation to breast and skin.

Cytopathology 2019 Apr 12. Epub 2019 Apr 12.

Dept of Pathology and Lab Medicine, AIIMS, Bhubaneswar, PIN-751019.

Malignancy to the breast is a rare form of breast malignancy (<1% of all breast tumors) with difficult diagnosis and often dismal prognosis. Melanoma, hematological malignancies and rhabdomyosarcoma commonly affect the breast secondarily although the carcinomas of pulmonary, ovarian and renal origin are also reported to metastatize to the breast. The metastatic symptoms could be the first symptom to the patient and becomes a diagnostic challenge for both the clinician and the pathologist. Read More

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http://dx.doi.org/10.1111/cyt.12703DOI Listing

Spectrum of cytomorphological features of extranodal NK/ T-cell lymphoma, nasal type.

Cytopathology 2019 Apr 12. Epub 2019 Apr 12.

Medicine, All India Institute of Medical Sciences, New Delhi.

Objective: Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is an aggressive extranodal lymphoma of NK-cell or T-cell lineage. Its clinical features overlap with those of several sinonasal mass lesions. While the histopathologic features are well described, diagnosis is often difficult, owing to presence of extensive coagulative necrosis, so that repeated biopsies may sometimes be necessary for correct diagnosis. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cyt.12705
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http://dx.doi.org/10.1111/cyt.12705DOI Listing
April 2019
3 Reads

Family communication and patient distress after germline genetic testing in individuals with pancreatic ductal adenocarcinoma.

Cancer 2019 Apr 12. Epub 2019 Apr 12.

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Boston, Massachusetts.

Background: Germline genetic testing currently is recommended for patients with pancreatic ductal adenocarcinoma (PDAC). In the current study, the authors assessed how often results are communicated to first-degree relatives within 3 months and the emotional impact of testing on patients.

Methods: A total of 148 patients who were newly diagnosed with PDAC and who had undergone testing of 32 cancer susceptibility genes at 3 academic centers were selected; 71% participated. Read More

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http://dx.doi.org/10.1002/cncr.32077DOI Listing
April 2019
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Autophagy inhibition overcomes sorafenib resistance in S45F-mutated desmoid tumors.

Cancer 2019 Apr 12. Epub 2019 Apr 12.

Program in Translational Therapeutics, The James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.

Background: Desmoid tumors (DTs) are rare and understudied fibroblastic lesions that are frequently recurrent and locally invasive. DT patients often experience chronic pain, organ dysfunction, decrease in quality of life, and even death.

Methods: Sorafenib has emerged as a promising therapeutic strategy, which has led to the first randomized phase 3 clinical trial devoted to DTs. Read More

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http://dx.doi.org/10.1002/cncr.32120DOI Listing

Desmoid tumor: A focus set on a challenging but understudied rare disease.

Authors:
Bernd Kasper

Cancer 2019 Apr 12. Epub 2019 Apr 12.

Sarcoma Unit, Interdisciplinary Tumor Center Mannheim, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.

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http://dx.doi.org/10.1002/cncr.32119DOI Listing

Incidence of hepatocellular carcinoma among older Americans attributable to hepatitis C and hepatitis B: 2001 through 2013.

Cancer 2019 Apr 12. Epub 2019 Apr 12.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland.

Background: In the United States, incidence and mortality rates of hepatocellular carcinoma (HCC) are increasing in older individuals. Chronic infection with hepatitis C virus (HCV) and hepatitis B virus (HBV) are important causes of HCC; however, the contribution of viral hepatitis to recent trends in HCC incidence among older Americans is unclear.

Methods: Data from the Surveillance, Epidemiology, and End Results-Medicare linkage (SEER-Medicare) for the years 2001 through 2013 were used to identify HCC cases among individuals aged ≥66 years and Medicare files were used to assess the HCV and HBV status of these HCC cases. Read More

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http://dx.doi.org/10.1002/cncr.32129DOI Listing
April 2019
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Optimal management of gastroesophageal junction cancer.

Cancer 2019 Apr 11. Epub 2019 Apr 11.

Gastrointestinal Oncology Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, New York.

Although recent decades have witnessed incremental improvements in the treatment of gastroesophageal junction (GEJ) carcinoma, outcomes remain modest. For locally advanced esophageal cancer, the addition of chemotherapy and/or radiation to surgery is considered the standard of care. Chemotherapy remains the primary treatment for metastatic disease and improves survival over best supportive care. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32066
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http://dx.doi.org/10.1002/cncr.32066DOI Listing
April 2019
3 Reads

Medicare and patient spending among beneficiaries diagnosed with chronic myelogenous leukemia.

Cancer 2019 Apr 11. Epub 2019 Apr 11.

Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, Birmingham, Alabama.

Background: The authors examined Medicare spending and patient spending in older patients with chronic myelogenous leukemia (CML) over the first 5 years from the time of CML diagnosis in the tyrosine kinase inhibitor (TKI) era.

Methods: Medicare beneficiaries with CML who were diagnosed between 2007 and 2012 at age >65 years were identified from the Surveillance, Epidemiology, and End Results (SEER)-Medicare database (805 beneficiaries). A noncancer Medicare beneficiary sample was frequency-matched based on age, sex, and race/ethnicity (805 individuals). Read More

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http://dx.doi.org/10.1002/cncr.32137DOI Listing
April 2019
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'Forget me not': urine cytology in a male with hematuria.

Cytopathology 2019 Apr 8. Epub 2019 Apr 8.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh.

Tuberculosis (TB) of the urinary tract is a common disease in developing countries of the world. Establishing a clinical diagnosis is challenging owing to the variable clinical presentations of the disease and often a high index of suspicion is required. Identification of epithelioid cell granulomas, Langhans' type of multinucleated giant cells, variable inflammation and demonstration of acid fast bacilli on Ziehl-Neelson (ZN) stain are essential for establishing a cytologic diagnosis. Read More

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http://dx.doi.org/10.1111/cyt.12700DOI Listing
April 2019
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Temporal trends in liver cancer mortality by educational attainment in the United States, 2000-2015.

Cancer 2019 Apr 8. Epub 2019 Apr 8.

Surveillance and Health Services Research Program, American Cancer Society, Atlanta, Georgia.

Background: Liver cancer is the most rapidly rising cause of cancer death in the United States. However, it is unclear whether the mortality trend differs by socioeconomic and/or hepatitis C virus (HCV) infection status.

Methods: Joinpoint analyses and Poisson regression modeling were performed to examine trends in death rates from liver cancer by education and HCV infection status among persons aged 25 to 74 years from 2000 to 2015. Read More

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http://dx.doi.org/10.1002/cncr.32023DOI Listing

Fine needle aspiration cytology of a recurrent hand swelling.

Cytopathology 2019 Apr 6. Epub 2019 Apr 6.

Department of Cytology and Gynecologic Pathology.

A 55 year female presented with a recurrent hard, fixed, ulcerated swelling measuring 2.5 x 2.2x 2 cm over left dorsum of hand in web space at level of third and fourth metacarpals (figure 1a). Read More

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http://dx.doi.org/10.1111/cyt.12699DOI Listing
April 2019
5 Reads

Multiple myeloma epidemiology and patient geographic distribution in Canada: A population study.

Cancer 2019 Apr 5. Epub 2019 Apr 5.

Division of Dermatology, University of Ottawa, Ottawa, Ontario, Canada.

Background: Multiple myeloma (MM) is a malignancy of mature plasma cells. Environmental risk factors identified for this malignancy, among others, include farming and exposure to pesticides.

Methods: Using 3 independent population-based databases (the Canadian Cancer Registry, le Registre Québécois du Cancer, and Canadian Vital Statistics), this study analyzed patients' clinical characteristics and the incidence, mortality, and geographic distribution of MM cases in Canada during 1992-2015. Read More

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http://dx.doi.org/10.1002/cncr.32128DOI Listing
April 2019
2 Reads

A genetic variation in the CpG island of pseudogene GBAP1 promoter is associated with gastric cancer susceptibility.

Cancer 2019 Apr 5. Epub 2019 Apr 5.

Department of Environmental Genomics, Center for Global Health, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center For Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China.

Background: Previous genome-wide association studies (GWASs) have identified that several single nucleotide polymorphisms (SNPs) are implicated in gastric cancer (GC) risk. However, the multiple statistical comparisons of GWASs may reject some true biological positives with subthreshold P values.

Methods: This study annotated the genomic locations of all CpG islands in the genome using the Encyclopedia of DNA Elements (ENCODE). Read More

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http://dx.doi.org/10.1002/cncr.32081DOI Listing

Daratumumab in multiple myeloma.

Cancer 2019 Apr 5. Epub 2019 Apr 5.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia.

The development of effective monoclonal antibodies for the treatment of myeloma has been a long journey of clinical and drug development. Identification of the right target antigen was a critical part of the process. CD38 as a target has been considered for some time, but clinically, daratumumab, a CD38 monoclonal antibody, was the first to be tested, and it has delivered the best clinical responses as a single agent to date. Read More

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http://dx.doi.org/10.1002/cncr.32065DOI Listing
April 2019
3 Reads

A phase 2, randomized trial evaluating the combination of dalantercept plus axitinib in patients with advanced clear cell renal cell carcinoma.

Cancer 2019 Apr 5. Epub 2019 Apr 5.

Fox Chase Cancer Center, Philadelphia, Pennsylvania.

Background: In a prior open-label study, the combination of dalantercept, a novel antiangiogenic targeting activin receptor-like kinase 1 (ALK1), plus axitinib was deemed safe and tolerable with a promising efficacy signal in patients with advanced renal cell carcinoma (RCC).

Methods: In the current phase 2, randomized, double-blind, placebo-controlled study, patients with clear cell RCC previously treated with 1 prior angiogenesis inhibitor were randomized 1:1 to receive axitinib plus dalantercept versus axitinib plus placebo. Randomization was stratified by the type of prior therapy. Read More

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http://dx.doi.org/10.1002/cncr.32061DOI Listing
April 2019
5 Reads

Diagnosis of urinary bladder urothelial carcinoma by immunocytology with p53, MCM5, MCM2 and Ki-67 antibodies using cell blocks derived from urine.

Cytopathology 2019 Apr 3. Epub 2019 Apr 3.

Department of Urology, 2nd Faculty of Medicine, Charles University, V Úvalu 84, 150 06, Prague, Czech Republic.

Objective: Immunocytochemistry has attained a marginal role in urology so far. Combining the morphological and immunophenotypical changes of the urothelial cells retrieved from urine is a logical approach. The study aimed to analyse the diagnostic potential of immunocytological staining in the detection of high grade and low grade urothelial carcinoma. Read More

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http://dx.doi.org/10.1111/cyt.12698DOI Listing

Errata.

Authors:

Cancer 2019 Apr 27;125(8):1387-1388. Epub 2019 Feb 27.

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http://dx.doi.org/10.1002/cncr.31887DOI Listing
April 2019
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Errata.

Authors:

Cancer 2019 Apr 1;125(8):1387. Epub 2019 Feb 1.

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http://dx.doi.org/10.1002/cncr.32021DOI Listing

Association between depth of response and survival in patients with advanced-stage non-small cell lung cancer treated with first-line chemotherapy.

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Celgene Corporation, Summit, New Jersey.

Background: A partial response according to the Response Evaluation Criteria in Solid Tumors includes a wide range of changes in tumor size. This study evaluated whether further specification of tumor reduction based on the depth of response (DpR) would provide a more precise association with outcomes for patients with non-small cell lung cancer (NSCLC) treated with first-line platinum-based chemotherapy.

Methods: A retrospective analysis was performed for the randomized phase 3 CA031 trial in patients with NSCLC treated with carboplatin in combination with nab-paclitaxel or solvent-based paclitaxel. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32114
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http://dx.doi.org/10.1002/cncr.32114DOI Listing
April 2019
1 Read

Metastatic castration-sensitive prostate cancer: Abiraterone, docetaxel, or...

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Tulane Cancer Center, Tulane University, New Orleans, Louisiana.

For decades, the management of patients with advanced prostate cancer has been hormonal therapy, known as androgen deprivation therapy, which is intended to lower testosterone levels. Further incremental progress in the treatment of men with metastatic hormone-sensitive prostate cancer (mHSPC) has come from the addition of docetaxel or abiraterone acetate to androgen deprivation therapy for more aggressive upfront treatment regimens. Other combinatorial regimens testing the addition of novel therapies currently are in the late stages of development and are expected to further improve the clinical outcomes of these patients. Read More

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http://dx.doi.org/10.1002/cncr.32039DOI Listing
April 2019
2 Reads

Prevalence of germline variants in inflammatory breast cancer.

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Harvard Medical School, Boston, Massachusetts.

Background: Inflammatory breast cancer (IBC) is an uncommon and aggressive subtype of breast cancer associated with early disease recurrence and short survival. The prevalence of germline variants in cancer predisposition genes has not been systematically evaluated in women with IBC.

Methods: Among 301 women enrolled in the clinical IBC registry at a single institution between 2010 and 2017, 168 had documented genetic testing. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32062
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http://dx.doi.org/10.1002/cncr.32062DOI Listing
April 2019
4 Reads

Biopharmacological considerations for accelerating drug development of deguelin, a rotenoid with potent chemotherapeutic and chemopreventive potential.

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Cancer Science Institute of Singapore, National University of Singapore, Singapore.

Deguelin is a rotenoid compound that exists in abundant quantities in the bark, roots, and leaves of the Leguminosae family of plants. An analysis of evidence from both in vitro and in vivo studies suggests that deguelin displays potent anticancer activity against multiple cancer types and exhibits chemopreventive potential in Akt-inducible transgenic mouse models. Deguelin appears to impede carcinogenesis by enhancing cell apoptosis and hindering malignant transformation and tumor cell propagation. Read More

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http://dx.doi.org/10.1002/cncr.32069DOI Listing
April 2019
3 Reads
4.889 Impact Factor

Rural-urban residence and cancer survival in high-income countries: A systematic review.

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Cancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.

There is some evidence that place of residence is associated with cancer survival, but the findings are inconsistent, and the underlying mechanisms by which residential location might affect survival are not well understood. We conducted a systematic review of observational studies investigating the association of rural versus urban residence with cancer survival in high-income countries. We searched the Ovid Medline, EMBASE, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) databases up to May 31, 2016. Read More

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http://dx.doi.org/10.1002/cncr.32073DOI Listing

Yoga for symptom management in oncology: A review of the evidence base and future directions for research.

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada.

Because yoga is increasingly recognized as a complementary approach to cancer symptom management, patients/survivors and providers need to understand its potential benefits and limitations both during and after treatment. The authors reviewed randomized controlled trials (RCTs) of yoga conducted at these points in the cancer continuum (N = 29; n = 13 during treatment, n = 12 post-treatment, and n = 4 with mixed samples). Findings both during and after treatment demonstrated the efficacy of yoga to improve overall quality of life (QOL), with improvement in subdomains of QOL varying across studies. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.31979
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http://dx.doi.org/10.1002/cncr.31979DOI Listing
April 2019
6 Reads

Mutation of chromatin regulators and focal hotspot alterations characterize human papillomavirus-positive oropharyngeal squamous cell carcinoma.

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Moores Cancer Center, University of California San Diego, La Jolla, California.

Background: Human papillomavirus (HPV)-associated oropharyngeal cancer is a disease clinically and biologically distinct from smoking-related head and neck squamous cell carcinoma (HNSCC). Despite its rapidly increasing incidence, the mutational landscape of HPV+ oropharyngeal squamous cell carcinoma (OPSCC) remains understudied.

Methods: This article presents the first mutational analysis of the 46 HPV+ OPSCC tumors within the newly expanded cohort of 530 HNSCC tumors from The Cancer Genome Atlas. Read More

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http://dx.doi.org/10.1002/cncr.32068DOI Listing
April 2019
4 Reads

Tailored management of primary gastrointestinal stromal tumors.

Cancer 2019 Apr 1. Epub 2019 Apr 1.

Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

Gastrointestinal stromal tumors (GISTs) are the most common human sarcoma and can form along the entire gastrointestinal tract. Over the last 20 years, considerable advances have been made in our understanding of the biology of GISTs. The advent of tyrosine kinase inhibitors has provided effective medical therapy for the first time. Read More

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http://dx.doi.org/10.1002/cncr.32067DOI Listing
April 2019
2 Reads

Concordance of Breast Fine Needle Aspiration Cytology Interpretation with Subsequent Surgical Pathology: An 18 Year Review from a Single Sub-Saharan African Institution.

Cytopathology 2019 Mar 30. Epub 2019 Mar 30.

Department of Laboratory Medicine, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.

Introduction: There are many merits to fine needle aspiration cytology (FNAC) in evaluation of palpable breast lesions. We set out to determine the concordance of breast FNAC interpretation with subsequent surgical pathology in the resource-limited healthcare setting of rural Kenya.

Methods: African Inland Church (AIC) Kijabe Hospital electronic pathology files were retrospectively reviewed from 1/1999-9/2017. Read More

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http://dx.doi.org/10.1111/cyt.12696DOI Listing
March 2019
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Addition of Analysis of KRAS Mutation or Immunohistochemistry with MUC1 and CEA Improves the Diagnostic Performance of the Fine-Needle Aspiration Cytology for the Diagnosis of Pancreatic Carcinoma.

Cytopathology 2019 Mar 31. Epub 2019 Mar 31.

Unit of Biomedical Research in Cancer, Institute of Biomedical Research, National Autonomous University of Mexico, Instituto Nacional de Cancerologia, Mexico City, Mexico.

Background: Pancreatic adenocarcinoma (PAC) is a health problem because of high lethality, increasing incidence, and the absence of an early diagnosis. Biopsy by fine-needle aspiration guided by endoscopic ultrasound (FNA-EUS) has allowed obtaining tissue for cytopathological analysis, but there are several problems with their interpretation. We aimed to compare the diagnostic performance of the cytopathological analysis with the addition of either an immunohistochemical (IHC) panel or the KRAS mutation for the diagnosis of PAC. Read More

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http://dx.doi.org/10.1111/cyt.12697DOI Listing
March 2019
1 Read

Willingness to bear adversity and beliefs about the curability of advanced cancer in older adults.

Cancer 2019 Mar 28. Epub 2019 Mar 28.

Department of Psychiatry, University of Rochester School of Medicine and Dentistry, Rochester, New York.

Background: Older patients with advanced cancer who are 100% certain they will be cured pose unique challenges for clinical decision making, but to the authors' knowledge, the prevalence and correlates of absolute certainty about curability (ACC) are unknown.

Methods: Cross-sectional data were collected in a geriatric assessment trial. ACC was assessed by asking patients, "What do you believe are the chances that your cancer will go away and never come back with treatment?" Response options were 100% (coded as ACC), >50%, 50/50, <50%, 0%, and uncertain. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/cncr.32074
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http://dx.doi.org/10.1002/cncr.32074DOI Listing
March 2019
7 Reads

Inotuzumab ozogamicin versus standard of care in relapsed or refractory acute lymphoblastic leukemia: Final report and long-term survival follow-up from the randomized, phase 3 INO-VATE study.

Cancer 2019 Mar 28. Epub 2019 Mar 28.

Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio.

Background: Inotuzumab ozogamicin (InO) is an antibody-drug conjugate used for adults with relapsed/refractory B-cell precursor (BCP) acute lymphoblastic leukemia (ALL). The INotuzumab Ozogamicin trial to inVestigAte Tolerability and Efficacy (INO-VATE) previously reported improved outcomes with InO versus standard-of-care (SoC) chemotherapy. This article reports the final INO-VATE results (≥2 years of follow-up) and additional analyses of patient characteristics associated with improved outcomes. Read More

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http://dx.doi.org/10.1002/cncr.32116DOI Listing
March 2019
1 Read

African American patients may or may not have poorer response rates after monoclonal antibody treatment: Overreliance on P values in underpowered studies.

Authors:
Mark A Fiala

Cancer 2019 Mar 28. Epub 2019 Mar 28.

Division of Oncology, Washington University School of Medicine, St Louis, Missouri.

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http://dx.doi.org/10.1002/cncr.32082DOI Listing

Multiple subcutaneous swellings in a young female.

Cytopathology 2019 Mar 27. Epub 2019 Mar 27.

Department of Cytology and Gynecological Pathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Pilomatricoma is a relatively rare, benign skin appendageal neoplasm with predilection for head and neck region, young age and female sex. Cytological diagnosis is often challenging owing to the lack of awareness and failure to identify the characteristic cytomorphologic features, often leading to misdiagnoses. Development of multiple pilomatricomas is very rare with only a few cases reported in the literature. Read More

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http://dx.doi.org/10.1111/cyt.12695DOI Listing
March 2019
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High-intensity end-of-life care among children, adolescents, and young adults with cancer who die in the hospital: A population-based study from the French national hospital database.

Cancer 2019 Mar 26. Epub 2019 Mar 26.

Aix-Marseille University, EA 3279 CEReSS - Health Service Research and Quality of Life Center, Marseille, France.

Background: Efforts to improve the quality of end-of-life (EOL) care depend on better knowledge of the care that children, adolescents, and young adults with cancer receive, including high-intensity EOL (HI-EOL) care. The objective was to assess the rates of HI-EOL care in this population and to determine patient- and hospital-related predictors of HI-EOL from the French national hospital database.

Methods: This was a population-based, retrospective study of a cohort of patients aged 0 to 25 years at the time of death who died at hospital as a result of cancer in France between 2014 and 2016. Read More

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http://dx.doi.org/10.1002/cncr.32035DOI Listing
March 2019
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