3,251,578 results match your criteria Cytopathology [Journal]
Methods Mol Biol 2019 ;1894:145-159
Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, Louisville, KY, USA.
DNA double-strand breaks (DSBs), one of the most severe lesions of DNA damage triggered by various genotoxic insults, can lead to chromosome change, genomic instability, and even tumorigenesis if not repaired efficiently. In response to DNA damage, histone H2AX molecules are rapidly phosphorylated at serine 139 near the site of DNA DSBs and form γ-H2AX foci. As an early important cellular event linked to DNA damage and repair, γ-H2AX is a highly sensitive biomarker for "monitoring" DNA damage and consequently is a useful tool in genetic toxicology screen. Read More
Int J Hematol 2018 Dec 13. Epub 2018 Dec 13.
Division of Hematology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec 2, Shih-Pai Road, Taipei, 112, Taiwan.
Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a rare form of cytotoxic T-cell lymphoma. It is believed that SPTL in patients without hemophagocytic syndrome (HPS) follows an indolent course; in contrast, SPTL in patients with HPS has been associated with unfavorable survival. To provide more clinical data on SPTL in Asian populations and to identify optimal therapeutic strategies for SPTL, we assessed the clinicopathological features and long-term follow-up data of 10 Taiwanese SPTL patients diagnosed at a single center. Read More
Surg Endosc 2018 Dec 13. Epub 2018 Dec 13.
University of Tennessee Medical Center at Knoxville, 1934 Alcoa Highway, Bldg. D, Ste. 370, Knoxville, TN, 37920, USA.
Background: Transanal minimally invasive surgery (TAMIS) has gained worldwide popularity as a method for the local excision of rectal neoplasms. However, it is technically demanding due to limited working space. Robotic TAMIS offers potential enhanced dexterity and ability while allowing for a more aggressive resection with a stable platform. Read More
J Clin Immunol 2018 Dec 13. Epub 2018 Dec 13.
Paediatric Immunology Unit, Department of Paediatric Pulmonology, Allergology and Neonatology, Hanover Medical School, Carl-Neuberg Str. 1, 30625, Hannover, Germany.
Studies of chest computed tomography (CT) in patients with primary antibody deficiency syndromes (ADS) suggest a broad range of bronchial pathology. However, there are as yet no multicentre studies to assess the variety of bronchial pathology in this patient group. One of the underlying reasons is the lack of a consensus methodology, a prerequisite to jointly document chest CT findings. Read More
Eur Arch Paediatr Dent 2018 Dec 13. Epub 2018 Dec 13.
Department of Pathology and Dentistry Clinic, School of Dentistry, Federal University of Piauí, Campus Universitário Ministro Petrônio Portella, bloco 5, Programa de Pós-Graduação em Odontologia, Bairro Ininga, Teresina, Piauí, 64049-550, Brazil.
Forensic Sci Med Pathol 2018 Dec 13. Epub 2018 Dec 13.
Charité - Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Institute of Legal Medicine and Forensic Sciences, Berlin, Germany.
Forensic routine consists of more than just the classical legal medicine described in textbooks. It is often crucial to answer forensic questions that involve numerous interfaces with other medical disciplines. These interdisciplinary questions that arise in routine autopsy proceedures can also be addressed scientifically, despite decreasing autopsy numbers. Read More
Esophagus 2018 Dec 13. Epub 2018 Dec 13.
AI Medical Service Inc., Tokyo, Japan.
Background And Aims: The endocytoscopic system (ECS) helps in virtual realization of histology and can aid in confirming histological diagnosis in vivo. We propose replacing biopsy-based histology for esophageal squamous cell carcinoma (ESCC) by using the ECS. We applied deep-learning artificial intelligence (AI) to analyse ECS images of the esophagus to determine whether AI can support endoscopists for the replacement of biopsy-based histology. Read More
Eur J Pediatr 2018 Dec 13. Epub 2018 Dec 13.
Clinical Genetics Department, Our Lady's Children's Hospital, Dublin, Ireland.
The filamin A gene (FLNA) on Xq28 encodes the filamin A protein. Mutation in FLNA causes a wide spectrum of disease including skeletal dysplasia, neuronal migration abnormality, cardiovascular malformation, intellectual disability and intestinal obstruction. Recently, childhood-onset interstitial lung disease associated with a range of FLNA mutations has been recognised and reported. Read More
Geroscience 2018 Dec 13. Epub 2018 Dec 13.
Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT, 84322, USA.
Cardiovascular disease, rare in premenopausal women, increases sharply at menopause and is typically accompanied by chronic inflammation. Previous work in our laboratory demonstrated that replacing senescent ovaries in post-reproductive mice with young, actively cycling ovaries restored many health benefits, including decreased cardiomyopathy and restoration of immune function. Our objective here was to determine if depletion of germ cells from young transplanted ovaries would alter the ovarian-dependent extension of life and health span. Read More
J Nucl Cardiol 2018 Dec 13. Epub 2018 Dec 13.
Turku PET Centre, University of Turku, 20520, Turku, Finland.
Background: Activation of glucagon-like peptide-1 receptor (GLP-1R) signaling protects against cardiac dysfunction and remodeling after myocardial infarction (MI). The aim of the study was to evaluate Ga-NODAGA-exendin-4 positron emission tomography (PET) for assessment of GLP-1R expression after MI in rats.
Methods And Results: Rats were studied at 3 days, 1 and 12 weeks after permanent coronary ligation or a sham-operation. Read More
Pathol Oncol Res 2018 Dec 13. Epub 2018 Dec 13.
Division of Biomedical Science and Biochemistry, Research School of Biology, ANU College of Medicine, Biology and Environment, Australian National University, P.O. Box: 2601, Canberra, Australia.
Diffuse gastric cancer (DGC) is one of the two primary types of stomach cancer. Carriers of germline mutations in the gene encoding E-cadherin are predisposed to DGC. The primary aim of the present study was to determine if genomic instability is an early event in DGC and how it may lead to disease progression. Read More
Clin Exp Metastasis 2018 Dec 13. Epub 2018 Dec 13.
Department of Pathology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands.
Programmed death-1 (PD-1) is an immune checkpoint that is able to inhibit the immune system by binding to its ligand programmed death-ligand 1 (PD-L1). In many cancer types, among which breast cancer, prognostic and/or predictive values have been suggested for both PD-1 and PD-L1. Previous research has demonstrated discrepancies in PD-L1 expression between primary breast tumors and distant metastases, however data so far have been scarce. Read More
Clin Exp Nephrol 2018 Dec 13. Epub 2018 Dec 13.
Department of Nephrology and Rheumatology, Aichi Medical University, 1-1 Yazakokarimata, Nagakute, Aichi, 480-1195, Japan.
Background: The morphological changes induced by bio-incompatible peritoneal dialysis (PD) solutions are well known. However, the morphological damage induced by long-term low-glucose degradation product (GDP), pH-neutral solutions has not been reported in detail. The aim of this study was to investigate the long-term effects of pH-neutral PD solutions on morphological and functional changes in the peritoneal membrane. Read More
Cancer Metastasis Rev 2018 Dec 14. Epub 2018 Dec 14.
Department of Cancer Biology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, 66160, USA.
Many inbred strains of mice develop spontaneous tumors as they age. Recent awareness of the impacts of mitochondrial DNA (mtDNA) on cancer and aging has inspired developing a mitochondrial-nuclear exchange (MNX) mouse model in which nuclear DNA is paired with mitochondrial genomes from other strains of mouse. MNX mice exhibit mtDNA influences on tumorigenicity and metastasis upon mating with transgenic mice. Read More
Breast Cancer Res Treat 2018 Dec 13. Epub 2018 Dec 13.
Department of Human Pathology in Adulthood and Childhood "G. Barresi", University Hospital of Messina, Messina, Italy.
EJNMMI Res 2018 Dec 13;8(1):110. Epub 2018 Dec 13.
Department of Nuclear Medicine and Molecular Imaging, Division of Nuclear Medicine, KU Leuven, Herestraat 49, 3000, Leuven, Belgium.
Background: F-FDG brain PET measures metabolic changes in neurodegenerative disorders and may discriminate between different diseases even at an early stage. The objective of this study was to classify patients with amyotrophic lateral sclerosis (ALS) and Parkinson plus syndromes (PP). To this end, different approaches were evaluated using generalized linear models and corresponding glucose metabolic brain patterns. Read More
Diabetologia 2018 Dec 14. Epub 2018 Dec 14.
Institute of Cellular Medicine, Faculty of Clinical Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Acta Neuropathol 2018 Dec 13. Epub 2018 Dec 13.
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Göteborgsvägen 31, House V3/SU, 43180, Mölndal, Sweden.
Tau is an axonal microtubule-binding protein. Tau pathology in brain and increased tau concentration in the cerebrospinal fluid (CSF) are hallmarks of Alzheimer's disease (AD). Most of tau in CSF is present as fragments. Read More
Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.
Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58th, The Second Zhongshan Road, Guangzhou, 510080, Guangdong, China.
Purpose: To investigate the feasibility of prediction for targeted therapy-related gene expression in hepatocellular carcinoma (HCC) using preoperative gadoxetic acid-enhanced magnetic resonance imaging (MRI).
Materials And Methods: Ninety-one patients (81 men, mean age 53.9 ± 12 years) with solitary HCC who underwent preoperative enhanced MRI were retrospectively analyzed. Read More
Eur Radiol 2018 Dec 13. Epub 2018 Dec 13.
Department of Radiology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan II Road, Guangzhou, 510080, People's Republic of China.
Objectives: Intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (MRI) provides information on both perfusion and diffusion and has been used to evaluate Crohn's disease (CD) activity and fibrosis in children; however, there are no reports on its use in adults. We aimed to determine its value for detecting and grading intestinal fibrosis in adults with CD compared with contrast-enhanced imaging and traditional diffusion-weighted imaging using surgical histopathology as a reference standard.
Methods: Twenty-four adults with CD underwent preoperative IVIM, traditional diffusion-weighted, and contrast-enhanced imaging. Read More
Ophthalmol Retina 2018 Oct 7;2(10):1080-1082. Epub 2018 Jun 7.
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, MO (USA).
J Spine Surg 2018 Sep;4(3):681-683
Department of Pathology, Queen Elizabeth Hospital, Hong Kong, China.
J Spine Surg 2018 Sep;4(3):624-629
Department of Neurosurgery, Universidad Militar Nueva Granada, Bogotá, Colombia.
Background: Spinal fractures are becoming more frequent and should be handled as a severe and endemic pathology that requires timely diagnosis and adequate treatment. The classification of the AOSpine is currently the classification used for this type of fractures, not only for its approach, but to predict surgical management.
Methods: These patients had spinal fracture reduction procedures done through percutaneous way with expander endovertebral implants, and intraosseous fixation using SpineJack intravertebral implants plus Cohesion cement. Read More
J Spine Surg 2018 Sep;4(3):610-615
Department of Neurosurgery, School of Medicine, University of Thessaly, Larissa, Greece.
Background: Surgical treatment of adult degenerative scoliosis (DS) always remains a challenge and often necessitates complex multilevel surgery via traditional open approaches. However, the severity of the procedure, in association with the fact that many of these patients are at an advanced age with several comorbidities, results in high rate of complications. Therefore, during the last decade, minimally invasive procedures have gained a place in the treatment of this pathology. Read More
J Spine Surg 2018 Sep;4(3):583-587
The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation, Oswestry, Shropshire, UK.
Background: The aim of this study was to investigate whether massive lumbar disc herniations (LDH) can be managed safely with non-operative treatment. Whilst most LDH are treated successfully with analgesia and physiotherapy, there is little literature regarding the treatment of massive LDH. Their impressive size raises the suspicion that they may cause cauda equina syndrome and are therefore often treated surgically. Read More
J Spine Surg 2018 Sep;4(3):560-567
Department of Orthopaedics, The Ohio State University Wexner Medical Center, Columbus, OH, USA.
Background: Wound complications can occur in up to 20% of patients following multilevel posterior spinal fusion. Currently, the use of local flaps has been reported in high-risk patients with a history of spinal neoplasm, radiation therapy, exposed hardware, multiple spine surgeries, or wound infections. However, there are no reports of prophylactic muscle flap wound closure in patients undergoing multi-level spinal fusion for degenerative pathology. Read More
J Spine Surg 2018 Sep;4(3):546-552
Department of Orthopaedic Surgery, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Background: Chordomas are rare malignant tumors of the spinal column often afflicting the upper cervical spine and sacrum. There are few large single center series on chordomas due to its rarity. The purpose of this study is to report a single center's experience with the operative and non-operative management of chordomas. Read More
Clin Transl Radiat Oncol 2019 Feb 14;15:1-6. Epub 2018 Nov 14.
Advanced Technology Center, Sheba Medical Center, Ramat-Gan 52621, Israel.
•Of 310 brain tumors patients recruited, histology of 99 lesions was available.•Of those, 5 were histologically confirmed as radiation-induced malformations.•TRAMs cannot differentiate active tumor from vascular malformation. Read More
Clin Transl Radiat Oncol 2019 Jan 17;14:51-58. Epub 2018 Nov 17.
Department of Urology, Nara Medical University, Japan.
Purpose: To investigate chronological changes in lower urinary tract symptoms (LUTS) in patients who received iodine-125 brachytherapy (BT) for prostate cancer.
Methods: We enrolled 706 patients who received BT. Of these, 265 (38%) received BT combined with external beam radiation therapy (EBRT). Read More
Cannabis Cannabinoid Res 2018 10;3(1):242-251. Epub 2018 Dec 10.
Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California.
Legalization of cannabis (CB) for both medicinal and, in some states, recreational use, has given rise to increasing usage rates across the country. Of particular concern are indications that frequent CB use may be selectively harmful to the developing adolescent brain compared with adult-onset usage. However, the long-term effects of heavy, adolescent CB use on brain structure and cognitive performance in late-life remain unknown. Read More
Acad Pathol 2018 Jan-Dec;5:2374289518816502. Epub 2018 Dec 4.
Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, USA.
Acute kidney injury, especially early-stage disease, is a common hospital comorbidity requiring timely recognition and treatment. We investigated the effect of daily laboratory alerting of patients at risk for acute kidney injury as measured by documented diagnoses. A quasi-experimental study was conducted at 8 New York hospitals between January 1, 2014, and June 30, 2017. Read More
Bio Protoc 2018 Nov;8(21)
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, USA.
Sendai virus (SeV) is an enveloped, single-stranded RNA virus of the family . SeV is a useful tool to study its infectious pathomechanism in immunology and the pathomechanism of a murine model of IgA nephropathy. Virus quantification is essential not only to determine the original viral titers for an appropriate application, but also to measure the viral titers in samples from the harvests from experiments. Read More
Mol Ther Methods Clin Dev 2018 Dec 18;11:131-142. Epub 2018 Oct 18.
Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by high levels of pathogenic autoantibodies and tissue damage. Multiple studies showed that dendritic cell (DC) activation plays a critical role in SLE pathogenesis. Human alpha 1 antitrypsin (hAAT) is a serine proteinase inhibitor with potent anti-inflammatory and cytoprotective properties. Read More
Front Mol Biosci 2018 28;5:105. Epub 2018 Nov 28.
Laboratory of Gene Expression, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
RBM20 is a vertebrate-specific RNA-binding protein with two zinc finger (ZnF) domains, one RNA-recognition motif (RRM)-type RNA-binding domain and an arginine/serine (RS)-rich region. has initially been identified as one of dilated cardiomyopathy (DCM)-linked genes. RBM20 is a regulator of heart-specific alternative splicing and mice lacking the RRM domain are defective in the splicing regulation. Read More
Front Oncol 2018 28;8:571. Epub 2018 Nov 28.
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, United States.
Testicular germ cell tumors are unique among solid cancers. Historically, this disease was deadly if progressed beyond the stage I. The implementation of cisplatin-based chemotherapy regimens has drastically changed the clinical outcome of metastatic testicular cancer. Read More
Front Oncol 2018 28;8:567. Epub 2018 Nov 28.
Division of Neuropathology, University of Alberta Hospital, Edmonton, AB, Canada.
Atypical teratoid/rhabdoid tumor in adults is a relatively rare malignant neoplasm. It is characterized by the presence of rhabdoid cells in combination with loss of either the INI1 or BRG1protein from the tumor cells. A systematic review was conducted using MEDLINE using the terms "atypical teratoid rhabdoid tumor" AND "adult. Read More
Cureus 2018 Oct 10;10(10):e3437. Epub 2018 Oct 10.
Otolaryngology, Aga Khan University Hospital, Karachi, PAK.
Introduction Ameloblastoma is a locally destructive tumor with a propensity for recurrence if not entirely excised. Management of ameloblastoma poses a challenge for all involved in the field of head and neck surgery because successful treatment requires not only adequate resection but also a functional and aesthetically acceptable reconstruction of the residual defect. Methods Patients who had histologically proven ameloblastoma between 1991 and 2009 were identified from the database of Aga Khan University Hospital. Read More
Cureus 2018 Oct 9;10(10):e3432. Epub 2018 Oct 9.
Otolaryngology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.
Cecal leiomyomas are rare benign tumors of smooth muscle arising from the colonic muscularis mucosa or muscularis propria. They are usually asymptomatic in nature and, if symptomatic, may present as pain in the abdomen, intestinal obstruction, or bleeding. In some cases, leiomyoma can cause free perforation leading to peritonitis. Read More
Cureus 2018 Oct 9;10(10):e3430. Epub 2018 Oct 9.
Colorectal Surgery, Royal Prince Alfred Hospital, Sydney, AUS.
This report is of a rare case involving a 27-year-old female who presented to the hospital with the pathological couplet of colocolic intussusception and cecal bascule causing bowel obstruction. Up to the time of presentation to the hospital, this patient had not undergone a full investigation for a known iron deficiency, anemia. Subsequently, during the emergency admission and after having an operative surgical procedure, the patient was found to have both a congenitally malpositioned cecum and a benign colonic polyp-forming condition. Read More
Cureus 2018 Oct 8;10(10):e3424. Epub 2018 Oct 8.
Otolaryngology, Aristotle University of Thessaloniki, Thessalonki, GRC.
Nikolai Ivanovich Pirogov is considered one of the most important anatomists and surgeons in the history of medicine. The Russian physician conducted more than 11,000 dissections and meticulously studied human anatomy, discovering important anatomical regions such as Pirogov's triangle. Pirogov developed surgical methods and techniques used by physicians for many decades such as Pirogov's amputation. Read More
Oncoimmunology 2019 31;8(1):e1524695. Epub 2018 Oct 31.
Department of Medicine, Vanderbilt University, Nashville, TN, USA.
Colitis is a frequent, clinically-significant immune-related adverse event caused by anti-programmed death-1 (PD-1). The clinical features, timing, and management of colitis with anti-PD-1-based regimens are not well-characterized. Patients with advanced melanoma that received either anti-PD-1 monotherapy ("monotherapy") or combined with ipilimumab ("combination therapy") were screened from 8 academic medical centers, to identify those with clinically-relevant colitis (colitis requiring systemic steroids). Read More
Oncoimmunology 2019 26;8(1):e1515612. Epub 2018 Sep 26.
The Danish HNPCC Register, Clinical Research Centre, Copenhagen University Hospital, Hvidovre Hospital, Hvidovre, Denmark.
Colorectal cancers associated with Lynch syndrome are characterized by defective mismatch repair, microsatellite instability, high mutation rates, and a highly immunogenic environment. These features define a subset of cancer with a favorable prognosis and high likelihood to respond to treatment with anti-programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1) drugs. With the aim to define immune-evasive mechanisms and a potential impact hereof in colorectal cancers from Lynch syndrome hereditary cases with retained mismatch repair function, we immunohistochemically and transcriptionally profiled 270 tumors. Read More
Oncoimmunology 2019 6;8(1):e1515058. Epub 2018 Sep 6.
Vaccine and Immunotherapy Center, The Wistar Institute, Philadlephia, PA, USA.
Ovarian cancer is frequently diagnosed as peritoneal carcinomatosis. Unlike other tumor locations, the peritoneal cavity is commonly exposed to gut-breaching and ascending genital microorganisms and has a unique immune environment. IL-33 is a local cytokine that can activate innate and adaptive immunity. Read More
Oncoimmunology 2019 5;8(1):e1512943. Epub 2018 Sep 5.
Project neuroArm, Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.
Meningioma is the most common brain tumor in adults. Surgical resection remains the primary treatment. No chemotherapy exists. Read More
Oncoimmunology 2019 21;8(1):e1512942. Epub 2018 Sep 21.
Molecular Targeting Unit, Department of Research, Fondazione IRCCS Istituto Nazionale dei Tumori of Milan, Milan, Italy.
Through whole-transcriptome profiling of HER2+ breast carcinomas (BCs), we previously showed that those sensitive to trastuzumab are addicted to this oncoprotein and are enriched in immune pathways, raising the hypothesis that HER2 itself regulates immune cell recruitment. In the present study we investigated the relationship between HER2 activity and the pro-trastuzumab tumor immune milieu. Gene expression profiling and immunohistochemistry analysis of 53 HER2+ BCs showed that trastuzumab-sensitive tumors expressed significantly higher levels of chemokines involved in immune cell recruitment, with higher infiltration of T cells and monocytes, and higher levels of PD-1 ligands than tumors that do not benefit from trastuzumab. Read More
Oncoimmunology 2019 2;8(1):e1512458. Epub 2018 Nov 2.
German Cancer Consortium (DKTK), Heidelberg, Germany.
Tumor-infiltrating lymphocytes (TILs) are correlated to prognosis of several kinds of cancer. Most studies focused on T cells, while the role of tumor-associated B cells (TABs) has only recently gained more attention. TABs contain subpopulations with distinct functions, potentially promoting or inhibiting immune responses. Read More
Oncoimmunology 2019 11;8(1):e1512455. Epub 2018 Oct 11.
Department of Pediatrics, New York Medical College, Valhalla, NY, USA.
Pediatric and adult patients with recurrent/refractory Burkitt lymphoma (BL) continue to have poor outcomes, emphasizing the need for newer therapeutic agents. Bruton's tyrosine kinase (BTK) is activated following B-cell receptor stimulation and in part regulates normal B-cell development. Ibrutinib, a selective and irreversible BTK inhibitor, has been efficacious in chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), Waldenström's macroglobulinemia, and marginal zone lymphoma. Read More
Oncoimmunology 2019 1;8(1):e1510710. Epub 2018 Oct 1.
Department of Pathology and Immunology, University of Geneva Medical School, Gemeva, Switzerland.
We have recently demonstrated that intratumoral CpG-B vaccination enhances anti-tumor immunity and tumor regression in mice. We further show that the local delivery of TLR9 agonists converts the tolerogenic tumor microenvironment into an immunopermissive one, which may benefit current immunotherapeutic anticancer strategies by enhancing innate and adaptive tumor-associated immune cell responses. Read More
Oncoimmunology 2019 11;8(1):e1505174. Epub 2018 Oct 11.
Institut National de la Santé et de la Recherche Medicale (INSERM), UMRS1138, Centre de Recherche des Cordeliers, Paris, France.
In non-small cell lung carcinoma (NSCLC), stimulation of toll-like receptor 7 (TLR7), a receptor for single stranded RNA, is linked to tumor progression and resistance to anticancer chemotherapy. However, the mechanism of this effect has been elusive. Here, using a murine model of lung adenocarcinoma, we demonstrate a key role for TLR7 expressed by malignant (rather than by stromal and immune) cells, in the recruitment of myeloid derived suppressor cells (MDSCs), induced after TLR7 stimulation, resulting in accelerated tumor growth and metastasis. Read More