304 results match your criteria Cytomegalovirus Esophagitis


Infectious esophagitis in children.

J Pediatr Gastroenterol Nutr 2022 Jun 10. Epub 2022 Jun 10.

Department of Pediatric Gastroenterology, Sydney Children's Hospital.

Infectious esophagitis is the third most common cause of esophagitis after gastroesophageal reflux disease and eosinophilic esophagitis (EoE) 1 and should always be considered in the differential of patients with dysphagia and odynophagia. The most common organisms causing disease are candida, Herpes simplex virus (HSV) and Cytomegalovirus (CMV). It is well recognised that an impaired local or systemic immune system is a risk factor for disease, however esophageal dysmotility and disruptions in esophageal homeostasis and the esophageal milieu are likely to represent additional risk factors in disease pathogenesis. Read More

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Simultaneous Occurrence of Cytomegalovirus Colitis and Retinitis as the Initial Presentation of Human Immunodeficiency Virus Infection in a Patient With Zero CD4 Count.

Cureus 2022 Feb 21;14(2):e22455. Epub 2022 Feb 21.

Medicine/Infectious Diseases, King Abdulaziz Medical City, Jeddah, SAU.

Cytomegalovirus (CMV) can be a reason for severe disease in immunocompromised patients, either via the reactivation of latent CMV infection or via the acquisition of primary CMV infection. Clinical syndromes that may be observed are retinitis, colitis, esophagitis, encephalitis, pneumonitis, hepatitis, uveitis, and graft rejection following transplantation. The simultaneous occurrence of CMV colitis and retinitis as the initial presentation of human immunodeficiency virus (HIV) infection is extremely rare. Read More

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February 2022

Risk Factors, Clinical and Endoscopic Features, and Clinical Outcomes in Patients with Cytomegalovirus Esophagitis.

J Clin Med 2022 Mar 13;11(6). Epub 2022 Mar 13.

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou Branch, Taoyuan 333, Taiwan.

Cytomegalovirus (CMV) esophagitis is the second most common CMV disease of the gastrointestinal tract. This study aims to comprehensively analyze risk factors, clinical characteristics, endoscopic features, outcomes, and prognostic factors of CMV esophagitis. We retrospectively collected data of patients who underwent esophageal CMV immunohistochemistry (IHC) staining between January 2003 and April 2021 from the pathology database at the Chang Gung Memorial Hospital. Read More

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Risks of Opportunistic Infections in People With Human Immunodeficiency Virus With Cancers Treated With Chemotherapy.

Open Forum Infect Dis 2021 Aug 19;8(8):ofab389. Epub 2021 Jul 19.

Icahn School of Medicine at Mt Sinai, New York, New York, USA.

Background: We ascertained incidence of opportunistic infections (OIs) in people with human immunodeficiency virus (PWH) with cancer undergoing chemotherapy with non-human immunodeficiency virus (HIV) comparators.

Methods: We identified 2106 PWH and 2981 uninfected Veterans with cancer who received at least 1 dose of chemotherapy between 1996 and 2017 from the Veterans Aging Cohort Study. We ascertained incident OIs within 6 months of chemotherapy amongst zoster, cytomegalovirus, tuberculosis, esophagitis, pneumonia (PCP), toxoplasmosis, Cryptococcosis, atypical infection, bacteremia, histoplasmosis, coccidioidomycosis, or progressive multifocal leukoencephalopathy. Read More

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CMV and HSV Pneumonia After Immunosuppressive Agents for Treatment of Cytokine Release Syndrome Due to Chimeric Antigen Receptor-modified T (CAR-T)-Cell Immunotherapy.

J Immunother 2021 Nov-Dec 01;44(9):351-354

Division of Allergy and Infectious Diseases, Department of Medicine.

Pneumonia due to cytomegalovirus and herpes simplex virus-1 caused substantial morbidity after hematopoietic cell transplantation before the institution of preventative approaches. End-organ disease from herpesviruses is poorly described after chimeric antigen receptor-modified T-cell immunotherapy. We report 2 cases of cytomegalovirus pneumonia and 1 case of herpes simplex virus-1 gingivostomatitis, esophagitis, and pneumonia after chimeric antigen receptor-modified T-cell immunotherapy for the treatment of hematologic malignancies. Read More

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February 2022

Clinical and Histopathologic Features Can Help Target Immunohistochemical Stain Use in the Diagnosis of Viral Esophagitis.

Appl Immunohistochem Mol Morphol 2021 Nov-Dec 01;29(10):713-719

Department of Pathology.

Objectives: Herpes simplex virus (HSV) and cytomegalovirus (CMV) immunohistochemical stains (IHC) are frequently applied on esophageal biopsies. Our aims were to identify IHC use patterns in viral esophagitis (VE), and clinicopathologic features of VE that could guide IHC use.

Methods: We included 58 VE cases and 60 controls, defined as patients with negative HSV/CMV IHC between January 2006 and July 2017. Read More

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Cytomegalovirus-associated esophagitis on early esophageal cancer in immunocompetent host: a case report.

Gut Pathog 2021 Apr 16;13(1):24. Epub 2021 Apr 16.

Department of Endoscopy, New Tokyo Hospital, 1271 Wanagaya, Matsudo, Chiba, 270-2232, Japan.

Background: Cytomegalovirus (CMV)-associated gastrointestinal diseases usually occur in immunocompromised patients; however, few cases has also been described in healthy hosts despite still unclear pathological mechanisms. CMV esophagitis causes various lesions, such as erythematous mucosa, erosions, and ulcers, although such inflammatory changes can appear in superficial esophageal cancers or in surrounding areas. CMV-associated esophagitis has been also reported in cancer patients, but typically in those with advanced and/or terminal stage cancers secondary to chemoradiotherapy-induced immunosuppression or the physiologic demands of the malignancy itself. Read More

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Cytomegalovirus and Herpes Simplex Virus Co-Infection in an HIV-Negative Patient: A Case Report.

Cureus 2021 Feb 8;13(2):e13214. Epub 2021 Feb 8.

Internal Medicine, Rutgers New Jersey Medical School, Newark, USA.

Herpes simplex virus (HSV) and cytomegalovirus (CMV) infections are commonly seen in immunocompromised patients, particularly in patients with HIV. However, fulminant CMV infection and concurrent infection with HSV and CMV in non-HIV patients are quite rare. We present the case of a 72-year-old HIV-negative man with a history of oropharyngeal carcinoma in remission and recent treatment of immune thrombocytopenic purpura with high-dose steroids who was transferred from an outside hospital for Ear Nose and Throat (ENT) evaluation of a non-healing buccal ulcer. Read More

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February 2021

Vaping-associated esophagitis.

BMC Gastroenterol 2021 Mar 5;21(1):106. Epub 2021 Mar 5.

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School Boston, 55 Fruit Street, Boston, MA, 02114, USA.

Background: Vaping, or e-cigarettes, heat nicotine and other chemicals to create a vapor that is inhaled. The practice has gained rapid popularity with 41 million people globally reporting regular or occasional use. Although tobacco smoking is well-known to increase esophageal acid exposure by augmenting the number of reflux events, the effects of vaping on the gastrointestinal tract have not yet been elucidated. Read More

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A Unique Case of Esophagitis in an Immunocompromised Patient.

Gastroenterology 2021 Sep 18;161(3):e8-e9. Epub 2021 Feb 18.

Department of Medicine, Max Rady Faculty of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

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September 2021

Machine learning approach for differentiating cytomegalovirus esophagitis from herpes simplex virus esophagitis.

Sci Rep 2021 02 11;11(1):3672. Epub 2021 Feb 11.

Department of Gastroenterology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-Ro 43-Gil, Songpa-gu, Seoul, 05505, Republic of Korea.

The endoscopic features between herpes simplex virus (HSV) and cytomegalovirus (CMV) esophagitis overlap significantly, and hence the differential diagnosis between HSV and CMV esophagitis is sometimes difficult. Therefore, we developed a machine-learning-based classifier to discriminate between CMV and HSV esophagitis. We analyzed 87 patients with HSV esophagitis and 63 patients with CMV esophagitis and developed a machine-learning-based artificial intelligence (AI) system using a total of 666 endoscopic images with HSV esophagitis and 416 endoscopic images with CMV esophagitis. Read More

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February 2021

[Evaluation and management of infectious esophagitis in immunocompromised patients and immunocompetent individuals].

Ter Arkh 2020 Sep 3;92(8):108-117. Epub 2020 Sep 3.

Sechenov First Moscow State Medical University (Sechenov University).

Among the many causes of the inflammatory process in the esophagus, infectious diseases are becoming increasingly important due to their steady growth. Previously esophageal infections have traditionally been associated with immunodeficiency syndromes, but now in clinical practice, these disorders are becoming increasingly recognized in immunocompetent individuals. Early diagnosis of infectious esophagitis is necessary to develop effective treatment tactics, and, as a result, reduce the risk of complications and adverse outcomes of the disease. Read More

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September 2020

Esophageal and virus co-infection in an immunocompromised patient: Case report and review of literature.

IDCases 2020 25;22:e00925. Epub 2020 Jul 25.

Pathology and Laboratory Medicine Department, American University of Beirut Medical Center, P.O. Box 11-0236, Riad El Solh, Beirut, 110-72020, Lebanon.

and co-infection has been reported to occur in a variety of sites in immunocompromised patients. To our knowledge, few cases of such co-infection have been reported to occur in the esophagus. We report a case of a 60-year-old woman who was maintained on immunosuppressive therapy for a presumed diagnosis of pemphigus vulgaris, who presented with odynophagia. Read More

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Giant Gastric Ulcers: An Unusual Culprit.

Dig Dis Sci 2020 10;65(10):2811-2817

Division of Gastroenterology and Hepatology, University of New Mexico, MSC 10-5550, Albuquerque, NM, 87131, USA.

Mycophenolate Mofetil (MMF) is routinely used immunosuppressant in solid organ transplantation is commonly associated with several gastrointestinal (GI) side effects. Here we present a case of giant gastric ulcer of 5 cm from MMF use post cardiac transplant. CASE DESCRIPTION: A 56-year-old male with history of severe ischemic cardiomyopathy post heart transplant was on immunosuppression with MMF, tacrolimus and prednisone for 5 months. Read More

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October 2020

A case of cytomegalovirus esophagitis during topical steroid therapy for eosinophilic esophagitis.

Clin J Gastroenterol 2020 Dec 1;13(6):1046-1050. Epub 2020 Sep 1.

Department of Gastroenterology, Tokyo Metropolitan Bokutoh Hospital, 4-23-15, Kotobashi, Sumida-ku, Tokyo, 130-8575, Japan.

Systemic immune deficiency is a major cause of cytomegalovirus (CMV) esophagitis. We report a case of CMV esophagitis during topical steroid therapy of eosinophilic esophagitis (EoE) in a non-immunodeficient patient. An 85-year-old man with dysphagia was on a 6-year regimen of oral budesonide (1200 mcg daily) for EoE. Read More

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December 2020

Cytomegalovirus esophagitis in a patient on ocrelizumab therapy: A case report.

Am J Health Syst Pharm 2020 08;77(16):1278-1279

University of South Florida-Morton Plant Mease Family Medicine Residency Turley Family Health Center Dr. Joseph A. Eaddy Family Medicine Research Center Clearwater, FL.

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Cytomegalovirus esophagitis with symptoms of gastroesophageal reflux disease in a kidney transplant recipient.

Kaohsiung J Med Sci 2020 Oct 15;36(10):859-860. Epub 2020 Jul 15.

Department of Gastroenterology and Hepatology, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

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October 2020

Cytomegalovirus-associated esophageal stricture as a manifestation of the immune reconstitution inflammatory syndrome.

IDCases 2020 11;21:e00795. Epub 2020 May 11.

Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Cytomegalovirus (CMV) esophagitis is well described in immunocompromised individuals, however, esophageal stricture due to CMV is rare. CMV disease in the setting of the immune reconstitution inflammatory syndrome (IRIS) usually takes the form of an immune-recovery uveitis or retinitis. We describe a young female patient with HIV who developed an esophageal stricture due to CMV within 6 months of starting antiretroviral therapy (ART). Read More

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Severe gastrointestinal bleeding due to synchronous herpes simplex virus and cytomegalovirus esophagitis.

Gastroenterol Hepatol 2020 Oct 30;43(8):449-450. Epub 2020 Apr 30.

Servicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Madrid, España.

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October 2020

Efficacy and Safety of Tocilizumab in the Treatment of Acute Active Antibody-mediated Rejection in Kidney Transplant Recipients.

Transplant Direct 2020 Apr 13;6(4):e543. Epub 2020 Mar 13.

Division of Nephrology, Washington University in St. Louis, St. Louis, MO.

Antibody-mediated rejection (AMR) continues to have a deleterious impact on kidney allograft survival. Recent evidence supports use of tocilizumab for treatment of chronic active AMR, but it has not been assessed for treatment of acute active AMR.

Methods: We performed a single-center, observational study of kidney transplant recipients who received at least 1 dose of tocilizumab in addition to conventional therapies for acute active AMR between October 2016 and October 2018 with follow-up through August 2019. Read More

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Infectious Esophagitis in Romanian Children: From Etiology and Risk Factors to Clinical Characteristics and Endoscopic Features.

J Clin Med 2020 Mar 30;9(4). Epub 2020 Mar 30.

Department of Microbiology, IuliuHatieganu University of Medicine and Pharmacy, 400151 Cluj-Napoca, Romania.

Objectives: The aim of this study is to provide information about prevalence, etiology, risk factors, clinical characteristics and endoscopic features of various types of infectious esophagitis in children.

Methods: We performed a total of 520 upper gastrointestinal tract endoscopies in Pediatric Clinic II, Emergency Hospital for Children, Cluj-Napoca. Indications for endoscopy in our cohort were gastrointestinal tract symptoms such as dysphagia, heartburn, or appetite loss. Read More

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Cytomegalovirus myocarditis in solid organ transplant recipients: A case series and review of literature.

Transpl Infect Dis 2020 Jun 11;22(3):e13282. Epub 2020 Apr 11.

Division of Infectious Disease, University of Colorado Denver, Aurora, CO, USA.

Cytomegalovirus (CMV) is a DNA virus of the Herpesviridae family and is estimated to affect 15%-30% of high-risk solid organ transplant recipients. Typical manifestations of CMV end-organ disease in this population include colitis, esophagitis, and pneumonitis, and myocarditis is a rarely reported manifestation. We describe two cases of CMV myocarditis in solid organ transplant recipients and review the literature regarding previously published cases of CMV myocarditis. Read More

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Educational Case: Infectious Esophagitis.

Acad Pathol 2020 Jan-Dec;7:2374289520903438. Epub 2020 Feb 6.

Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA, USA.

http://journals.sagepub.com/doi/10. Read More

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February 2020

Diagnosis and Treatment of Esophageal Candidiasis: Current Updates.

Can J Gastroenterol Hepatol 2019 20;2019:3585136. Epub 2019 Oct 20.

Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

Esophageal candidiasis (EC) is the most common type of infectious esophagitis. In the gastrointestinal tract, the esophagus is the second most susceptible to candida infection, only after the oropharynx. Immunocompromised patients are most at risk, including patients with HIV/AIDS, leukemia, diabetics, and those who are receiving corticosteroids, radiation, and chemotherapy. Read More

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Simultaneous candida albicans and herpes simplex virus type 2 esophagitis in a renal transplant recipient.

BMJ Case Rep 2019 Aug 15;12(8). Epub 2019 Aug 15.

Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, Georgia, USA.

Renal transplant recipients are prone to opportunistic infections due to iatrogenic immunosuppression. Infectious esophagitis can present as an opportunistic infection in the post-transplant period. Common pathogens are candida, herpes simplex virus (HSV) and cytomegalovirus (CMV). Read More

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Host Genetics of Cytomegalovirus Pathogenesis.

Front Genet 2019 23;10:616. Epub 2019 Jul 23.

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States.

Human cytomegalovirus (HCMV) is a ubiquitous herpes virus (human herpes virus 5) with the highest morbidity and mortality rates compared to other herpes viruses. Risk groups include very young, elderly, transplant recipient, and immunocompromised individuals. HCMV may cause retinitis, encephalitis, hepatitis, esophagitis, colitis, pneumonia, neonatal infection sequelae, inflammatory, and age-related diseases. Read More

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An Exclusively Skewed Distribution of Pediatric Immune Reconstitution Inflammatory Syndrome Toward the Female Sex Is Associated With Advanced Acquired Immune Deficiency Syndrome.

Front Pediatr 2019 10;7:293. Epub 2019 Jul 10.

Molecular Identification and Diagnosis Unit, Laboratory of Biotechnology, Center for Biosciences and Biotechnology, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.

In human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) patients with very low CD4 cell counts, there is a temporal relationship between administration of antiretroviral therapy (ART) and an increased inflammatory response state known as the immune reconstitution inflammatory syndrome (IRIS). The predominant clinical presentation of IRIS is an infectious disease that can be life-threatening. IRIS-related infectious events are distributed similarly between adult males and females, albeit a few studies have shown a skewing toward the male sex in pediatric IRIS. Read More

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Low dose valganciclovir as cytomegalovirus prophylaxis in post-renal transplant recipients induced with alemtuzumab: A single-center study.

Transpl Immunol 2019 10 22;56:101226. Epub 2019 Jul 22.

Department of Surgery, University of Toledo College of Medicine and Health Sciences, Toledo, OH, United States of America.

Objectives: Alemtuzumab (Ale) is a recombinant monoclonal antibody which binds to CD52 causing profound lymphodepletion, thus allowing its use in renal transplantation induction therapy. However, patients may be at increased risk for opportunistic infections, such as Cytomegalovirus (CMV). We analyzed CMV infection in renal allograft recipients administered low-dose valganciclovir (VGCV) prophylaxis with alemtuzumab induction and steroid minimization. Read More

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October 2019

[Esophageal actinomycosis in patients with HIV infection].

Rev Gastroenterol Peru 2019 Apr-Jun;39(2):160-163

Servicio de Anatomía Patológica, Hospital Guillermo Almenara Irigoyen. Lima, Perú.

Esophageal pathology is common in patients with HIV, frequently due to Candida, cytomegalovirus or herpes virus. However, esophageal actinomycosis is a rare infection, even in patients with HIV. We report the case of a 33-year-old male patient, with a recent diagnosis of HIV who was admitted for fever, odynophagia, dysphagia and retrosternal pain. Read More

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January 2020