287 results match your criteria Cytomegalovirus Esophagitis


Cytomegalovirus-associated esophageal stricture as a manifestation of the immune reconstitution inflammatory syndrome.

IDCases 2020 11;21:e00795. Epub 2020 May 11.

Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Cytomegalovirus (CMV) esophagitis is well described in immunocompromised individuals, however, esophageal stricture due to CMV is rare. CMV disease in the setting of the immune reconstitution inflammatory syndrome (IRIS) usually takes the form of an immune-recovery uveitis or retinitis. We describe a young female patient with HIV who developed an esophageal stricture due to CMV within 6 months of starting antiretroviral therapy (ART). Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242862PMC

Severe gastrointestinal bleeding due to synchronous herpes simplex virus and cytomegalovirus esophagitis.

Gastroenterol Hepatol 2020 Apr 30. Epub 2020 Apr 30.

Servicio de Gastroenterología y Hepatología, Hospital Universitario Ramón y Cajal, Madrid, España.

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http://dx.doi.org/10.1016/j.gastrohep.2020.02.014DOI Listing

Efficacy and Safety of Tocilizumab in the Treatment of Acute Active Antibody-mediated Rejection in Kidney Transplant Recipients.

Transplant Direct 2020 Apr 13;6(4):e543. Epub 2020 Mar 13.

Division of Nephrology, Washington University in St. Louis, St. Louis, MO.

Antibody-mediated rejection (AMR) continues to have a deleterious impact on kidney allograft survival. Recent evidence supports use of tocilizumab for treatment of chronic active AMR, but it has not been assessed for treatment of acute active AMR.

Methods: We performed a single-center, observational study of kidney transplant recipients who received at least 1 dose of tocilizumab in addition to conventional therapies for acute active AMR between October 2016 and October 2018 with follow-up through August 2019. Read More

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http://dx.doi.org/10.1097/TXD.0000000000000988DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7145000PMC

Infectious Esophagitis in Romanian Children: From Etiology and Risk Factors to Clinical Characteristics and Endoscopic Features.

J Clin Med 2020 Mar 30;9(4). Epub 2020 Mar 30.

Department of Microbiology, IuliuHatieganu University of Medicine and Pharmacy, 400151 Cluj-Napoca, Romania.

Objectives: The aim of this study is to provide information about prevalence, etiology, risk factors, clinical characteristics and endoscopic features of various types of infectious esophagitis in children.

Methods: We performed a total of 520 upper gastrointestinal tract endoscopies in Pediatric Clinic II, Emergency Hospital for Children, Cluj-Napoca. Indications for endoscopy in our cohort were gastrointestinal tract symptoms such as dysphagia, heartburn, or appetite loss. Read More

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http://dx.doi.org/10.3390/jcm9040939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7230472PMC

Cytomegalovirus myocarditis in solid organ transplant recipients: A case series and review of literature.

Transpl Infect Dis 2020 Jun 11;22(3):e13282. Epub 2020 Apr 11.

Division of Infectious Disease, University of Colorado Denver, Aurora, CO, USA.

Cytomegalovirus (CMV) is a DNA virus of the Herpesviridae family and is estimated to affect 15%-30% of high-risk solid organ transplant recipients. Typical manifestations of CMV end-organ disease in this population include colitis, esophagitis, and pneumonitis, and myocarditis is a rarely reported manifestation. We describe two cases of CMV myocarditis in solid organ transplant recipients and review the literature regarding previously published cases of CMV myocarditis. Read More

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http://dx.doi.org/10.1111/tid.13282DOI Listing

Educational Case: Infectious Esophagitis.

Acad Pathol 2020 Jan-Dec;7:2374289520903438. Epub 2020 Feb 6.

Pathology and Laboratory Medicine, University of California Davis School of Medicine, Sacramento, CA, USA.

http://journals.sagepub.com/doi/10. Read More

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http://dx.doi.org/10.1177/2374289520903438DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7005969PMC
February 2020

Diagnosis and Treatment of Esophageal Candidiasis: Current Updates.

Can J Gastroenterol Hepatol 2019 20;2019:3585136. Epub 2019 Oct 20.

Department of Gastroenterology, The Second Affiliated Hospital of Zhejiang University, Hangzhou, China.

Esophageal candidiasis (EC) is the most common type of infectious esophagitis. In the gastrointestinal tract, the esophagus is the second most susceptible to candida infection, only after the oropharynx. Immunocompromised patients are most at risk, including patients with HIV/AIDS, leukemia, diabetics, and those who are receiving corticosteroids, radiation, and chemotherapy. Read More

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http://dx.doi.org/10.1155/2019/3585136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6854261PMC

Simultaneous candida albicans and herpes simplex virus type 2 esophagitis in a renal transplant recipient.

BMJ Case Rep 2019 Aug 15;12(8). Epub 2019 Aug 15.

Nephrology, Hypertension and Transplant Medicine, Augusta University Health, Augusta, Georgia, USA.

Renal transplant recipients are prone to opportunistic infections due to iatrogenic immunosuppression. Infectious esophagitis can present as an opportunistic infection in the post-transplant period. Common pathogens are candida, herpes simplex virus (HSV) and cytomegalovirus (CMV). Read More

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http://dx.doi.org/10.1136/bcr-2019-230410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6700596PMC
August 2019
2 Reads

Host Genetics of Cytomegalovirus Pathogenesis.

Front Genet 2019 23;10:616. Epub 2019 Jul 23.

Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States.

Human cytomegalovirus (HCMV) is a ubiquitous herpes virus (human herpes virus 5) with the highest morbidity and mortality rates compared to other herpes viruses. Risk groups include very young, elderly, transplant recipient, and immunocompromised individuals. HCMV may cause retinitis, encephalitis, hepatitis, esophagitis, colitis, pneumonia, neonatal infection sequelae, inflammatory, and age-related diseases. Read More

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http://dx.doi.org/10.3389/fgene.2019.00616DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6664682PMC
July 2019
4 Reads

An Exclusively Skewed Distribution of Pediatric Immune Reconstitution Inflammatory Syndrome Toward the Female Sex Is Associated With Advanced Acquired Immune Deficiency Syndrome.

Front Pediatr 2019 10;7:293. Epub 2019 Jul 10.

Molecular Identification and Diagnosis Unit, Laboratory of Biotechnology, Center for Biosciences and Biotechnology, Universidade Estadual do Norte Fluminense Darcy Ribeiro, Campos dos Goytacazes, Brazil.

In human immunodeficiency virus and acquired immune deficiency syndrome (HIV/AIDS) patients with very low CD4 cell counts, there is a temporal relationship between administration of antiretroviral therapy (ART) and an increased inflammatory response state known as the immune reconstitution inflammatory syndrome (IRIS). The predominant clinical presentation of IRIS is an infectious disease that can be life-threatening. IRIS-related infectious events are distributed similarly between adult males and females, albeit a few studies have shown a skewing toward the male sex in pediatric IRIS. Read More

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http://dx.doi.org/10.3389/fped.2019.00293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6635464PMC
July 2019
6 Reads

Low dose valganciclovir as cytomegalovirus prophylaxis in post-renal transplant recipients induced with alemtuzumab: A single-center study.

Transpl Immunol 2019 10 22;56:101226. Epub 2019 Jul 22.

Department of Surgery, University of Toledo College of Medicine and Health Sciences, Toledo, OH, United States of America.

Objectives: Alemtuzumab (Ale) is a recombinant monoclonal antibody which binds to CD52 causing profound lymphodepletion, thus allowing its use in renal transplantation induction therapy. However, patients may be at increased risk for opportunistic infections, such as Cytomegalovirus (CMV). We analyzed CMV infection in renal allograft recipients administered low-dose valganciclovir (VGCV) prophylaxis with alemtuzumab induction and steroid minimization. Read More

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http://dx.doi.org/10.1016/j.trim.2019.101226DOI Listing
October 2019
3 Reads

[Esophageal actinomycosis in patients with HIV infection].

Rev Gastroenterol Peru 2019 Apr-Jun;39(2):160-163

Servicio de Anatomía Patológica, Hospital Guillermo Almenara Irigoyen. Lima, Perú.

Esophageal pathology is common in patients with HIV, frequently due to Candida, cytomegalovirus or herpes virus. However, esophageal actinomycosis is a rare infection, even in patients with HIV. We report the case of a 33-year-old male patient, with a recent diagnosis of HIV who was admitted for fever, odynophagia, dysphagia and retrosternal pain. Read More

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January 2020
5 Reads

Cachexia, Colitis, and Cancer.

Gastroenterology 2020 02 16;158(3):488-490. Epub 2019 Jul 16.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1053/j.gastro.2019.07.021DOI Listing
February 2020
8 Reads

Severe Bleeding due to Cytomegalovirus Esophagitis in a Patient with Diabetes after Interbody Fusion Surgery.

Intern Med 2019 Oct 10;58(20):2949-2955. Epub 2019 Jul 10.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.

A 49-year-old man with diabetes taking clopidogrel and celecoxib underwent interbody fusion surgery for spinal spondylolysis. Ten days after the surgery, he vomited a large amount of fresh blood. A blood examination revealed hemodynamic failure. Read More

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http://dx.doi.org/10.2169/internalmedicine.2908-19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6859388PMC
October 2019
14 Reads

Can endoscopists differentiate cytomegalovirus esophagitis from herpes simplex virus esophagitis based on gross endoscopic findings?

Medicine (Baltimore) 2019 Jun;98(23):e15845

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine.

Differential diagnosis between herpes simplex virus (HSV) esophagitis and cytomegalovirus (CMV) esophagitis is challenging because there are many similarities and overlaps between their endoscopic features. The aims of this study were to investigate the implications of the endoscopic findings for the diagnosis of HSV and CMV esophagitis, and to develop a predictive model for differentiating CMV esophagitis from HSV esophagitis.Patients who underwent endoscopic examination and had pathologically-confirmed HSV or CMV esophagitis were eligible. Read More

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http://dx.doi.org/10.1097/MD.0000000000015845DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6571398PMC
June 2019
24 Reads

An uncommon case of herpetic esophagitis in a small child with allergic rhinitis: A case report and literature review (CARE compliant).

Medicine (Baltimore) 2019 May;98(20):e15601

University of Medicine, Pharmacy, Sciences and Technology, Târgu Mures, Romania.

Rationale: Herpetic esophagitis (HE) is a common condition in immunosuppressed patients, but a rare entity in immunocompetent patients affecting especially male teenagers and young adults.

Patient Concerns: We report the case of a 5-year-old male patient, with a history of allergic rhinitis admitted in our clinic for acute onset fever refractory to antipyretics, chest pain, anorexia, refusal of solid food, accepting only small amounts of fluids, odynophagia, and epigastric pain. The clinical exam revealed severe malaise, pallor, decreased skin turgor, abdominal epigastric tenderness, heartburn at palpation within the epigastric area. Read More

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http://dx.doi.org/10.1097/MD.0000000000015601DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6531067PMC
May 2019
6 Reads
5.723 Impact Factor

Risk Factors, Endoscopic Features, and Clinical Outcomes of Cytomegalovirus Esophagitis Based on a 10-year Analysis at a Single Center.

Clin Gastroenterol Hepatol 2020 Mar 8;18(3):736-738. Epub 2019 May 8.

Department of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

Cytomegalovirus (CMV) can infect multiple areas of the gastrointestinal tract, most commonly the esophagus and colon. CMV esophagitis is the third leading cause of infectious esophagitis, after Candida and herpes simplex virus. It occurs predominantly in immunocompromised hosts such as patients with human immunodeficiency virus (HIV) and is considered an acquired immunodeficiency syndrome (AIDS) defining illness. Read More

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http://dx.doi.org/10.1016/j.cgh.2019.04.066DOI Listing
March 2020
5 Reads
7.896 Impact Factor

Sequential infection by herpes simplex virus, Candida species, and Cytomegalovirus species in esophagus.

Gastrointest Endosc 2019 08 14;90(2):307-308. Epub 2019 Apr 14.

Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, Osaka, Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00165107193159
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http://dx.doi.org/10.1016/j.gie.2019.04.210DOI Listing
August 2019
16 Reads

A Fluttering Blue Hue Is Tough to Subdue.

Gastroenterology 2019 04 2;156(5):1255-1256. Epub 2019 Jan 2.

University of Alabama at Birmingham, Birmingham, Alabama.

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http://dx.doi.org/10.1053/j.gastro.2018.11.074DOI Listing
April 2019
3 Reads

Mononeuritis multiplex: an uncommon neurological manifestation of cytomegalovirus reactivation in an HIV-infected patient.

BMC Infect Dis 2018 Nov 12;18(1):554. Epub 2018 Nov 12.

Infectious Diseases Department, Centro Hospitalar de São João, Alameda Professor Hernâni Monteiro, 4200-319, Porto, Portugal.

Background: Cytomegalovirus (CMV) reactivation with neurological involvement in patients with acquired immunodeficiency syndrome (AIDS) is increasingly rare since the introduction of antiretroviral therapy (ART). Manifestations include encephalitis, myelitis, polyradiculopathy and, less commonly, mononeuritis multiplex (MNM). We report a case of disseminated CMV disease with gastrointestinal and peripheral and central nervous system involvement in a patient with AIDS, manifesting primarily as MNM. Read More

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https://bmcinfectdis.biomedcentral.com/articles/10.1186/s128
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http://dx.doi.org/10.1186/s12879-018-3501-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6233374PMC
November 2018
48 Reads

Cytomegalovirus pleuropericarditis after orthotopic liver transplantation.

Acta Gastroenterol Belg 2018 Jul-Sep;81(3):427-429

Antwerp University Hospital, Department of Gastroenterology and Hepatology.

Cytomegalovirus (CMV) reactivation is a common complication after liver transplantation. In patients with CMV infection, indicated by a positive CMV DNA titer, the presence of any clinical symptom is termed CMV disease. The most common organ affected in CMV disease is the gastrointestinal tract, causing esophagitis, gastritis, enteritis or colitis. Read More

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February 2019
8 Reads

Infections of the esophagus: an update on risk factors, diagnosis, and management.

Dis Esophagus 2018 Dec;31(12)

Division of Gastroenterology and Hepatology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Infectious esophagitis is a leading cause of esophagitis worldwide. While esophageal infections have traditionally been associated with immunocompromised patients, these disorders are becoming increasingly recognized in immunocompetent individuals. The three most common etiologies of infectious esophagitis are Candida, herpes simplex virus, and cytomegalovirus. Read More

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https://academic.oup.com/dote/advance-article/doi/10.1093/do
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http://dx.doi.org/10.1093/dote/doy094DOI Listing
December 2018
41 Reads

Fatal disseminated cytomegalovirus infection with necrotizing oophoritis in a patient with acquired immunodeficiency syndrome.

Autops Case Rep 2018 Jul-Sep;8(3):e2018029. Epub 2018 Jul 30.

Universidade de São Paulo, Faculty of Medicine, Department of Anatomic Pathology, Emergency Department and LIM06. São Paulo, SP, Brazil.

Disseminated human cytomegalovirus (CMV) disease occurs mainly as a congenital infection and among immunocompromised hosts. Patients with acquired immunodeficiency syndrome (AIDS) are at increased risk for CMV infection, and the most prevalent clinical manifestation is retinitis, followed by colitis, esophagitis, pneumonitis, and encephalitis. CMV oophoritis is poorly described in the literature with some cases reported in patients with hematological or solid malignancies, bone marrow or solid organ transplantation, immunosuppressive therapy, and advanced AIDS cases. Read More

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http://autopsyandcasereports.org/article/doi/10.4322/acr.201
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http://dx.doi.org/10.4322/acr.2018.029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6066265PMC
July 2018
22 Reads

Unique causes of esophageal inflammation: a histopathologic perspective.

Ann N Y Acad Sci 2018 12 16;1434(1):219-226. Epub 2018 May 16.

Department of Pathology, Yale School of Medicine, New Haven, Connecticut.

Gastroenterologists frequently perform endoscopic esophageal mucosal biopsies for pathologic diagnosis in patients experiencing symptoms of esophagitis. The more common causes of esophagitis diagnosed on esophageal mucosal biopsy include reflux esophagitis, eosinophilic esophagitis, and infectious esophagitis caused by Candida albicans, herpes simplex virus, and/or cytomegalovirus. However, there are several causes of esophagitis seen less frequently by pathologists that are very important to recognize. Read More

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http://dx.doi.org/10.1111/nyas.13732DOI Listing
December 2018
9 Reads

Role of Endoscopic Findings and Biopsies in Renal Transplant Recipients With Gastrointestinal Complications: A Tertiary Care Experience.

Exp Clin Transplant 2018 10 9;16(5):522-527. Epub 2018 Mar 9.

From the Department of Hepato-Gastroenterology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.

Objectives: We investigated the incidence of gastrointestinal disorders requiring endoscopic and histopathologic diagnoses in renal transplant recipients.

Materials And Methods: In this retrospective analysis, we examined records of patients seen at the Department of Hepato-Gastroenterology and Transplantation Sciences, Sindh Institute of Urology and Trans?lantation (Karachi, Pakistan) from January 2010 to December 2014. Renal transplant recipients with gastrointestinal disorders who required endoscopy, including proctoscopy and upper and lower gastrointestinal endoscopy as per indication, were included. Read More

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http://dx.doi.org/10.6002/ect.2017.0132DOI Listing
October 2018
18 Reads

Cytomegalovirus ulcerative oesophagitis in a young healthy immunocompetent patient.

BMJ Case Rep 2018 Mar 5;2018. Epub 2018 Mar 5.

Department of Gastroenterology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Cytomegalovirus (CMV) gastrointestinal disease usually arises in patients with immunodeficiency or immunosuppression, being rare in immunocompetent hosts. Although increasing in incidence, few cases of CMV gastrointestinal disease have been described among young healthy patients. Currently, there is uncertainty in approaching these patients, including the need for antiviral therapy that remains to be established. Read More

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http://dx.doi.org/10.1136/bcr-2017-223297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847831PMC
March 2018
7 Reads

A rare presentation of cytomegalovirus infection in an immunocompetent patient.

Gastrointest Endosc 2018 07 17;88(1):185-186. Epub 2018 Mar 17.

Gastroenterology Department, Centro Hospitalar Tondela-Viseu, Viseu, Portugal.

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http://dx.doi.org/10.1016/j.gie.2018.01.037DOI Listing
July 2018
8 Reads

Infectious esophagitis in the immunosuppressed: Candida and beyond.

J Community Med (Reno) 2018 5;1. Epub 2018 Apr 5.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA.

Infection is the second most common cause of esophagitis, second only to gastroesophageal reflux, and represents a clinically important disorder. Immunosuppressed patients are at highest risk for infectious esophagitis, with herpes simplex virus, and cytomegalovirus being the most common causative microorganisms. Here we provide a brief clinical review and present a case of concomitant oropharyngeal and presumed esophageal candidiasis in a patient with autoimmune hepatitis who was initiated on high-dose corticosteroid therapy and soon thereafter develop odynodysphagia and who was found to have herpes esophagitis diagnosed by endoscopy and histopathology. Read More

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http://dx.doi.org/10.33582/2637-4900/1004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6939767PMC

Early post-transplant diagnosis of cytomegalovirus esophagitis in an ABO-incompatible kidney transplant recipients: A case report.

Transpl Infect Dis 2018 Apr 25;20(2):e12827. Epub 2018 Jan 25.

Department of Nephrology and Hypertension, St. Marianna University School of Medicine, Kawasaki, Japan.

Cytomegalovirus (CMV) is a common infectious pathogen in kidney transplant patients. Here, we present a case of CMV esophagitis with antigenemia, that developed within 3 days of kidney transplantation, a timeline generally considered to be too early for development of a CMV infection. Intense immunosuppressive therapy for desensitization in ABO-incompatibility or in the presence of donor-specific antibody can increase the risk for significant opportunistic infection immediately after or even before transplantation. Read More

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http://dx.doi.org/10.1111/tid.12827DOI Listing
April 2018
70 Reads

Cytomegalovirus Disease of the Upper Gastrointestinal Tract: A 10-Year Retrospective Study.

GE Port J Gastroenterol 2017 Nov 2;24(6):262-268. Epub 2017 Sep 2.

Department of Gastroenterology, Lisbon, Portugal.

Background And Aims: Cytomegalovirus (CMV) disease of the gastrointestinal (GI) tract is a major cause of morbidity and mortality in immunocompromised patients. The colon is the most commonly affected site, and the literature is scarce regarding CMV disease of the upper GI tract. Therefore, our study aimed to evaluate the clinical and endoscopic features of upper GI CMV disease. Read More

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http://dx.doi.org/10.1159/000479232DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5731150PMC
November 2017
14 Reads

Severe esophagitis associated with cytomegalovirus during concurrent chemoradiotherapy for esophageal cancer.

Jpn J Clin Oncol 2017 Sep;47(9):885-888

Department of Clinical Oncology, Kyoto University Hospital, Kyoto, Japan.

Although radiation esophagitis is one of the most common adverse events that occurs during chemoradiotherapy (CRT) in patients with esophageal cancer, CRT-associated cytomegalovirus (CMV) esophagitis is rare. CMV esophagitis typically occurs in patients with an immunosuppressed status. Here we report a case of CMV esophagitis during CRT initially treated as radiation esophagitis. Read More

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http://dx.doi.org/10.1093/jjco/hyx083DOI Listing
September 2017
54 Reads

Varicella-Zoster Virus Gastritis: Case Report and Review of the Literature.

Int J Surg Pathol 2017 Aug 1;25(5):449-452. Epub 2017 Mar 1.

1 University of Calgary, Calgary, Alberta, Canada.

We report varicella-zoster virus (VZV) gastritis in a 70-year-old woman postchemotherapy for lymphoma, presenting with abdominal pain, vomiting, and delirium without rash. A gastric biopsy demonstrated viral inclusions but posed a diagnostic challenge as immunohistochemistry for cytomegalovirus and herpes simplex virus were negative, and VZV immunohistochemistry was not available. The patient developed a vesicular rash 7 days after her symptoms began. Read More

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http://journals.sagepub.com/doi/10.1177/1066896917696751
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http://dx.doi.org/10.1177/1066896917696751DOI Listing
August 2017
20 Reads

Celiac Crisis Associated with Herpes Simplex Virus Esophagitis.

ACG Case Rep J 2016 Aug 23;3(4):e159. Epub 2016 Nov 23.

Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University, Columbus, OH.

Celiac crisis is a rare presentation of celiac disease that is characterized by life-threatening electrolyte abnormalities, vitamin and mineral deficiencies, and diarrhea. Triggers for celiac crisis include major surgeries, pancreatitis, and infections of cytomegalovirus, and salmonella. A 24-year-old woman presented with celiac crisis associated with severe herpes simplex virus (HSV) esophagitis. Read More

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http://dx.doi.org/10.14309/crj.2016.132DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5126499PMC
August 2016
24 Reads
1 Citation

Periesophageal Pseudoaneurysms: Rare Cause of Refractory Bleeding Treated with Transarterial Embolization.

Case Rep Gastrointest Med 2016 12;2016:1456949. Epub 2016 Oct 12.

Division of Gastroenterology and Hepatology, Virginia Commonwealth University, Richmond, VA, USA.

A 43-year-old female with history of systemic lupus erythematosus, prior cytomegalovirus esophagitis treated with ganciclovir, and long segment Barrett's esophagus (Prague class C8 M9) with high grade dysplasia treated with radiofrequency ablation presented to the hospital with hematemesis. An upper gastrointestinal endoscopy showed multiple esophageal ulcers with active arterial spurting which could not be controlled with endoscopic interventions including placement of hemostatic clips. An emergent angiogram demonstrated actively bleeding saccular dilations (pseudoaneurysms) in the esophageal branches of the lower thoracic aorta as well as left gastric artery for which gelfoam and coil embolization was initially successful. Read More

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http://dx.doi.org/10.1155/2016/1456949DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5080469PMC
October 2016
10 Reads

Cytomegalovirus esophagitis developing during chemoradiotherapy for esophageal cancer: two case reports.

J Med Case Rep 2016 Sep 21;10(1):259. Epub 2016 Sep 21.

Department of Gastroenterology, National Center of Global Health and Medicine, 1-21-1 Toyama Shinjuku-ku, Tokyo, 162-8655, Japan.

Background: It is well known that cytomegalovirus esophagitis occurs in immunosuppressed patients. However, few reports have described cytomegalovirus esophagitis occurring during chemoradiotherapy for esophageal cancer.

Case Presentation: We report two cases of patients with cytomegalovirus esophagitis that developed during chemoradiotherapy for esophageal cancer. Read More

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http://jmedicalcasereports.biomedcentral.com/articles/10.118
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http://dx.doi.org/10.1186/s13256-016-0947-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5031298PMC
September 2016
13 Reads

Esophagitis Caused by Cytomegalovirus Infection in an Immune-competent Patient.

Clin Gastroenterol Hepatol 2016 12 29;14(12):e143-e144. Epub 2016 Jun 29.

Department of Gastroenterology, Sendai Kousei Hospital, Sendai-City, Miyagi, Japan.

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http://dx.doi.org/10.1016/j.cgh.2016.06.016DOI Listing
December 2016
8 Reads

Care of Patients With HIV Infection: Medical Complications and Comorbidities.

FP Essent 2016 Apr;443:16-22

University of Massachusetts Medical School, 55 N Lake Ave, Worcester, MA 01655.

Care of patients with HIV infection starts with diagnosis as soon as possible, preferably at or near the time of acute infection. Opportunistic infections, malignancies, and other conditions develop progressively over time, particularly in untreated patients. The AIDS-defining opportunistic infections most common in the United States include Pneumocystis jirovecii pneumonia, Candida esophagitis, toxoplasmic encephalitis, tuberculosis, disseminated Mycobacterium avium complex, cryptococcal meningitis, and cytomegalovirus retinitis. Read More

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April 2016
38 Reads

Evaluation and Management of Infectious Esophagitis in Immunocompromised and Immunocompetent Individuals.

Curr Treat Options Gastroenterol 2016 Mar;14(1):28-38

Division of Gastroenterology and Hepatology, Johns Hopkins University School of Medicine, 4940 Eastern Avenue, A Building, Room 344B, Baltimore, MD, 21224, USA.

Opinion Statement: Among the many inflammatory processes that may account for esophageal symptoms, infection represents an important etiologic category with numerous clinically relevant subdivisions. While features of the history and physical exam are informative, diagnosis often hinges on endoscopic visualization and histopathologic analysis. This chapter will review in series the most clinically relevant causative agents for infectious esophagitis, with specific diagnostic and therapeutic features of note divided into one of two immune milieus. Read More

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http://dx.doi.org/10.1007/s11938-016-0082-2DOI Listing
March 2016
11 Reads

Extensive Esophageal Ulceration in a Renal Transplant Patient.

GE Port J Gastroenterol 2016 Mar-Apr;23(2):116-118. Epub 2015 Oct 9.

Gastroenterology Department, Centro Hospitalar São João, Faculty of Medicine of the University of Porto, Porto, Portugal.

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http://dx.doi.org/10.1016/j.jpge.2015.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580169PMC
October 2015
7 Reads

Surgical manifestations of gastrointestinal cytomegalovirus infection in children: Clinical audit and literature review.

J Pediatr Surg 2015 Nov 30;50(11):1874-9. Epub 2015 Jun 30.

Department of Paediatric Surgery, Red Cross War Memorial Children's Hospital, Cape Town, South Africa.

Introduction: Gastrointestinal sequelae of cytomegalovirus are rare, usually associated with significant immune compromise, and carry a high morbidity and mortality. Gastrointestinal disease frequently requires surgical intervention for diagnosis and management.

Aim: The aim of the study is to evaluate the incidence, presentation and management of gastrointestinal cytomegalovirus disease in a pediatric population. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2015.06.018DOI Listing
November 2015
36 Reads

Esophageal infections: an update.

Curr Opin Pediatr 2015 Oct;27(5):642-8

aDivision of Infectious Disease and Immunology, Department of Pediatrics bDivision of Gastroenterology, Hepatology and Nutrition, Levine Children's Hospital, Carolinas Medical Center, Charlotte, North Carolina, USA.

Purpose Of Review: Infectious esophagitis generally occurs in patients with impaired immunity. Although methods to suppress the immune system evolve, the potential infectious consequences are poorly understood. The purpose of this article is to review the risk factors, diagnosis, and treatment of infectious esophagitis. Read More

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http://dx.doi.org/10.1097/MOP.0000000000000266DOI Listing
October 2015
10 Reads

Radiation esophagitis.

Arch Pathol Lab Med 2015 Jun;139(6):827-30

From the Department of Pathology, Rush University Medical Center, Chicago, Illinois.

The esophagus is frequently exposed to radiation during treatment of advanced stages of common cancers such as lung, breast, and esophagus. However, symptomatic radiation esophagitis requiring endoscopic and histologic evaluation occurs quite rarely, affecting less than 1% of patients receiving radiation treatment. Symptoms occur acutely, generally within the first 2 months. Read More

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http://www.archivesofpathology.org/doi/10.5858/arpa.2014-011
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http://dx.doi.org/10.5858/arpa.2014-0111-RSDOI Listing
June 2015
29 Reads

Symptomatic cytomegalovirus gastrointestinal infection with positive quantitative real-time PCR findings in apparently immunocompetent patients: a case series.

Clin Microbiol Infect 2015 Dec 22;21(12):1121.e1-7. Epub 2015 May 22.

University Clinic of Geriatric Medicine, Grenoble University Hospital, Grenoble, France.

Cytomegalovirus (CMV) gastrointestinal disease rarely occurs in immunocompetent patients, and is mainly diagnosed on the basis of histopathological findings. Real-time PCR for CMV DNA quantification is considered to be a useful diagnostic tool, but its place in the diagnostic strategy is not clearly defined. The goal of the study was to describe the clinical and paraclinical features of apparently immunocompetent patients with CMV gastrointestinal disease diagnosed according to quantitative PCR results. Read More

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http://dx.doi.org/10.1016/j.cmi.2015.05.016DOI Listing
December 2015
4 Reads

Severe viral oesophagitis, pharyngitis, and stomatitis as antecedents of ileocecal Crohn's disease.

Prz Gastroenterol 2015 6;10(1):47-50. Epub 2015 Feb 6.

Department of Gastroenterology and Hepatology, Medical University of Silesia, Katowice, Poland.

We present a 22-year-old male who developed a severe erosive oesophagitis extending to the pharynx and oral cavity without obvious risk factors. Endoscopic image suggested viral aetiology that could not be confirmed by routine serological diagnostics of infections with cytomegalovirus, Epstein-Barr virus, and Herpes simplex virus. The histopathological evaluation also gave no definite clues to the aetiology of the inflammation. Read More

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http://dx.doi.org/10.5114/pg.2014.47495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411404PMC
May 2015
14 Reads

Acyclovir versus valganciclovir for preventing cytomegalovirus infection in intermediate-risk liver transplant recipients.

Prog Transplant 2015 Mar;25(1):39-44

Hartford Hospital, Hartford, Connecticut.

Context: Cytomegalovirus (CMV) is an opportunistic infection that causes profound morbidity and mortality after orthotopic liver transplant (OLT). The CMV immunoglobulin G serostatuses of donors and recipients are the main factors influencing risk for development of CMV infection after transplant.

Objective: To compare acyclovir and valganciclovir for preventing CMV infection after OLT. Read More

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http://dx.doi.org/10.7182/pit2015558DOI Listing
March 2015
14 Reads

Catastrophic gastrointestinal complication of systemic immunosuppression.

World J Gastroenterol 2015 Feb;21(8):2542-5

Lyn Alexandra Smith, Daniel R Gaya, Gastroenterology Unit, Glasgow Royal Infirmary, G4 0SF Glasgow, United Kingdom.

We present a case of acute upper gastrointestinal haemorrhage in a patient with systemic vasculitis immunosuppressed on cyclophosphamide and prednisolone. The patient presented with a diffuse haemorrhagic oesophagitis and a non-specific duodenitis. Biopsies taken from the oesophagus and duodenum demonstrated infection with herpes simplex virus (HSV) and cytomegalovirus (CMV) respectively. Read More

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http://www.wjgnet.com/1007-9327/full/v21/i8/2542.htm
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http://dx.doi.org/10.3748/wjg.v21.i8.2542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342934PMC
February 2015
14 Reads

The clinical characteristics and manifestations of cytomegalovirus esophagitis.

Dis Esophagus 2016 May 26;29(4):392-9. Epub 2015 Feb 26.

Department of Pathology, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Esophagitis is the second most common gastrointestinal manifestation of cytomegalovirus (CMV) infection after colitis. CMV esophagitis has been reported in patients who have undergone transplantation, are on long-term renal dialysis, or who have the human immunodeficiency virus infection. This study aimed to investigate the clinical characteristics and manifestations of CMV esophagitis in patients who underwent diagnostic endoscopy. Read More

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http://dx.doi.org/10.1111/dote.12340DOI Listing
May 2016
50 Reads