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Case Rep Infect Dis 2020 21;2020:8498216. Epub 2020 Jun 21.

Division of Geographic Medicine and Infectious Diseases, Tufts Medical Center, Tufts University School of Medicine Clinical and Translational Science Institute, Boston, MA, USA.

A 54-year-old male, five months postorthotopic heart transplantation, presented with intermittent fevers, headaches, and "soupy" stools. Prior to presentation, he had low-level cytomegalovirus (CMV) viremia for two straight weeks. Given his immunosuppression, diarrhea, and low-level CMV viremia, he was presumed to have cytomegalovirus and/or colitis and treated empirically for both on hospital day one. Read More

Scand J Gastroenterol 2020 Jul 7:1-6. Epub 2020 Jul 7.

Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.

Objectives: Cytomegalovirus (CMV) infection is common in the general population. CMV infection negatively affects disease course in transplant recipients and HIV patients. Whereas primary CMV infections may occur sporadically in seronegative patients, all seropositive patients with inflammatory bowel syndrome (IBD) are at risk for CMV reactivation due to the inflammatory mucosal and use of immunosuppressive medication. Read More

Inflamm Intest Dis 2020 Jun 10;5(2):49-58. Epub 2020 Mar 10.

Clinical Gastroenterology, Universidade de Caxias do Sul, Caxias do Sul, Brazil.

Aim: To report a case of a female patient with hemophagocytic lymphohistiocytosis (HLH) and to systematically review the available cases of the association between HLH and inflammatory bowel disease (IBD).

Methods: In accordance to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines, retrieval of studies was based on Medical Subject Headings and Health Sciences Descriptors, which were combined using Boolean operators. Searches were run on the electronic databases Scopus, Web of Science, MEDLINE (PubMed), Biblioteca Regional de Medicina, Latin American and Caribbean Health Sciences Literature, Cochrane Library for Systematic Reviews and Opengrey. Read More

Scand J Gastroenterol 2020 Jun 19;55(6):664-670. Epub 2020 Jun 19.

The Maria Sklodowska-Curie National Research Institute of Oncology, Department of Gastroenterology, Warsaw, Poland.

In severe ulcerative colitis (UC) bowel biopsy is recommended to detect the cytomegalovirus (CMV) infection capable of complicating the course of the disease. Histopathology with immunohistochemistry (IHC) is time-consuming, and a blood polymerase chain reaction (PCR) for CMV DNA is used as an alternative, notwithstanding nothing more than a moderate correlation between the two. We aimed to detect CMV DNA in the stools of patients with active UC, and to compare the results with CMV IHC in bowel biopsies. Read More

J Pediatric Infect Dis Soc 2020 Jun 14. Epub 2020 Jun 14.

Department of Pediatrics, Division of Infectious Diseases, University of Nebraska Medical Center, Omaha, Nebraska, USA.

We report a case of disseminated tularemia in a previously healthy 8-month-old male. This case highlights an atypical presentation of tularemia with multisystem organ involvement. The diagnosis was complicated by concurrent primary cytomegalovirus infection. Read More

Case Rep Gastroenterol 2020 May-Aug;14(2):279-285. Epub 2020 May 13.

Department of Gastroenterology, National Hospital Organization Hakodate National Hospital, Hakodate, Japan.

Cytomegalovirus (CMV) colitis with a cobblestone appearance is rare, and its endoscopic and pathological features remain poorly described. A 78-year-old woman was admitted to our hospital for disturbance of consciousness, high-grade fever, and diarrhea occurring up to 7 times a day. Sigmoidoscopy revealed a circumferential ulcer with mucosal defect, an ulcer with a cobblestone appearance extending from the upper rectum to the sigmoid colon, and an irregular ulcer on the lower rectum. Read More

Surg Case Rep 2020 Jun 1;6(1):121. Epub 2020 Jun 1.

Department of General Surgery, Toyohashi Municipal Hospital, 50 Hachiken-nishi, Aotake-cho, Toyohashi, Aichi, 441-8570, Japan.

Background: Ulcerative colitis (UC) developing during chemotherapy is very rare. Here, we describe a case of acute onset during chemoradiotherapy for lung adenocarcinoma, requiring a total proctocolectomy.

Case Presentation: A 52-year-old man was admitted to the hospital for chemoradiotherapy of lung cancer. Read More

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):583-587

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To compare the differences in the detection rates of cytomegalovirus (CMV) infection between the left and right colons for guiding endoscopic biopsy-sites. The cases of colonic CMV infection confirmed by histology at the Peking Union Medical College Hospital from July 2015 to July 2018 were collected and analyzed. Splenic curvature was used as the dividing point between the left and right colons. Read More

BMJ Case Rep 2020 May 19;13(5). Epub 2020 May 19.

Department of Gastroenterology and Hepatology, Cleveland Clinic Foundation, Cleveland, Ohio, USA.

As immune checkpoint inhibitors (ICIs) are increasingly used, clinicians are more frequently encountering the side effects of these therapies. ICIs have been implicated in numerous adverse effects against healthy tissues. We present a case of a patient who developed treatment refractory checkpoint inhibitor colitis. Read More

Urol Int 2020 May 19:1-6. Epub 2020 May 19.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Introduction: Splenectomy had been previously performed in ABO-incompatible kidney transplantation to reduce the B cell pool. However, studies have shown that patients undergoing splenectomy may have a lifelong susceptibility to infection and mortality. Splenectomy may affect the incidence of cytomegalovirus (CMV) disease even at a very late stage after transplantation in ABO-incompatible recipients. Read More

Mater Sociomed 2020 Mar;32(1):41-45

Division of Gastroenterology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Introduction: infection (CDI) has been reported to be a cause of flare-ups in patients with inflammatory bowel disease (IBD). Cytomegalovirus (CMV) infection can cause severe disease and complications in immunocompromised patients in consequence of disease or therapy.

Aim: Our aim was to describe the prevalence and clinical outcomes of CDI with concomitant CMV infection in IBD patients hospitalized for flare-ups in association with the disease itself and medication used. Read More

J Crohns Colitis 2020 Apr 28. Epub 2020 Apr 28.

University Hospital of St Etienne, Department of Hepatology and Gastroenterology, St Etienne, France.

Turk J Gastroenterol 2020 Mar;31(3):274-275

Department of Internal Medicine, American University of Beirut Medical Center, Bone Marrow Transplantation Program, Beirut, Lebanon.

Int J Mol Sci 2020 Mar 31;21(7). Epub 2020 Mar 31.

Department of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo 060-8543, Japan.

Human cytomegalovirus (HCMV) is a ubiquitous herpesvirus (the human herpesvirus 5) and an opportunistic pathogen that primarily infects HIV-positive and other immuno-compromised patients. Retrospective studies in the field of inflammatory bowel disease (IBD) have suggested a relationship between a concomitant colonic HCMV infection and poor outcomes in patients with an ulcerative colitis (UC) due to the presence of HCMV in surgical specimens of patients with a toxic megacolon or a steroid-resistant UC. Therefore, gastroenterologists have focused on the contribution of HCMV infections in the exacerbation of UC. Read More

Thorac Cancer 2020 Jun 2;11(6):1699-1702. Epub 2020 Apr 2.

Department of Pulmonary and Critical Care Medicine, Peking Union Medical Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Immune checkpoint inhibitors, the new standard in cancer therapy, present durable responses in numerous solid tumors and hematologic malignancies, as well as resulting in an increased incidence of immune-related adverse events (irAEs). Diarrhea is a common irAE, with an incidence rate of approximately 10% to 13%. It is important to distinguish between diarrhea symptomatic of an infection, which is the main differential diagnosis, and immune-related diarrhea. Read More

Transpl Infect Dis 2020 Jun 11;22(3):e13282. Epub 2020 Apr 11.

Division of Infectious Disease, University of Colorado Denver, Aurora, CO, USA.

Cytomegalovirus (CMV) is a DNA virus of the Herpesviridae family and is estimated to affect 15%-30% of high-risk solid organ transplant recipients. Typical manifestations of CMV end-organ disease in this population include colitis, esophagitis, and pneumonitis, and myocarditis is a rarely reported manifestation. We describe two cases of CMV myocarditis in solid organ transplant recipients and review the literature regarding previously published cases of CMV myocarditis. Read More

Case Rep Gastroenterol 2020 Jan-Apr;14(1):103-109. Epub 2020 Feb 25.

Department of Gastroenterology and Hepatology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan.

Although most immune-related adverse events (irAEs) secondary to immune checkpoint inhibitors can be managed with immunosuppressive therapies; they can induce reactivation of infectious diseases, including cytomegalovirus (CMV). Here, we show a case of CMV enterocolitis during steroid therapy for an irAE. A 77-year-old man with unresectable malignant melanoma was treated with ipilimumab. Read More

Expert Rev Gastroenterol Hepatol 2020 May 5;14(5):307-309. Epub 2020 May 5.

Department of Infectious Diseases and Clinical Microbiology, Istanbul Medeniyet University , Istanbul, Turkey.

Eur J Case Rep Intern Med 2020 11;7(3):001288. Epub 2020 Feb 11.

Department of Internal Medicine, "Santa Croce e Carle" Hospital, Cuneo, Italy.

Background: The causes of inflammatory bowel disease (IBD) have not yet been clearly elucidated, but it is known that genetic susceptibility, altered gut microbiota and environmental factors are all involved, and that a combination of these factors causes an inappropriate immune response, resulting in impaired intestinal barrier function. With regard to the treatment of IBD, the use of conventional immunosuppressive drugs has been complemented by more specific therapeutic agents, including biological drugs. Systemic immune suppression is a risk factor for cytomegalovirus (CMV) infection, which is associated with considerable morbidity and mortality in immunocompromised hosts. Read More

BMC Infect Dis 2020 Mar 20;20(1):237. Epub 2020 Mar 20.

Department of Pathology, Sidra Medicine, Level 2M, Office H2M-24093, PO BOX 26999, Doha, Qatar.

Background: Infections with multidrug-resistant organisms (MDRO) pose a serious threat to patients with dysregulated immunity such as in hemophagocytic lymphohistiocytosis (HLH), but such infections have rarely been comprehensively characterized. Here, we present a fatal case of HLH secondary to cytomegalovirus (CMV) infection complicated by both anti-viral drug resistance and sepsis from multiple MDROs including pandrug-resistant superbug bacteria.

Case Presentation: A previously healthy, six-year-old boy presented with a 45-day history of fever prior to a diagnosis of hemophagocytic lymphohistiocytosis and hemorrhagic colitis, both associated with CMV. Read More

Int J Colorectal Dis 2020 May 2;35(5):897-903. Epub 2020 Mar 2.

UCLA Center for Inflammatory Bowel Diseases, UCLA Vatche & Tamar Manoukian Divison of Digestive Diseases, University of California Los Angeles, Los Angeles, CA, USA.

Background: Cytomegalovirus (CMV) infection may complicate ulcerative colitis (UC) or Crohn's disease (CD) hospitalizations. Studies examining this relationship are often single-center examining short time periods.

Aims: To quantify the prevalence of CMV and its impact on outcomes among UC and CD hospitalizations over time using nationwide administrative databases. Read More

World J Clin Cases 2020 Feb;8(3):552-559

Department of Pathology, Yeungnam University College of Medicine, Daegu 42415, South Korea.

Background: Cytomegalovirus (CMV) enterocolitis presenting in the form of pancolitis or involving the small and large intestines in an immunocompetent patient is rarely encountered, and CMV enterocolitis presenting with a serious complication, such as toxic megacolon, in an immunocompetent adult has only been reported on a few occasions.

Case Summary: We describe the case of a 70-year-old male with no history of inflammatory bowel disease or immunodeficiency who presented with toxic megacolon and subsequently developed massive hemorrhage as a complication of CMV ileo-pancolitis. The patient was referred to our institute for abdominal pain and distension. Read More

J Crohns Colitis 2020 Feb 27. Epub 2020 Feb 27.

Gastroenterology and Liver Services, Concord Hospital, Sydney, Australia.

Despite multiple studies, the role of CMV infection in exacerbating the severity of inflammation in ulcerative colitis (UC) and its response to treatment remains debatable. Additionally, the optimal diagnostic tests for CMV infection in the setting of UC relapse and timing of antiviral treatment initiation remain unclear. The challenge faced by gastroenterologists is to differentiate between an acute UC flare and true CMV colitis. Read More

Transpl Infect Dis 2020 Apr 24;22(2):e13259. Epub 2020 Feb 24.

Division of Infectious Diseases, Carolinas Medical Center, Atrium Health, Charlotte, NC, USA.

Cytomegalovirus (CMV) is a common opportunistic infection in solid organ transplant (SOT) recipients in the first 6 months after transplant. Late onset CMV infection or disease outside the classical risk period is uncommon and can present with atypical signs and symptoms. Here, we report a case of late onset CMV presenting as a colonic stricture more than 10 years after liver transplantation in the absence of traditional CMV risk factors. Read More

Arch Rheumatol 2019 Dec 22;34(4):447-450. Epub 2019 Apr 22.

Department of Rheumatology, Katip Çelebi University Atatürk Training and Research Hospital, İzmir, Turkey.

Cytomegalovirus infection, which can occur as a result of reactivation due to immunosuppressive treatment in patients with granulomatosis with polyangiitis, is a serious condition that should be kept in mind because of its fatal course. In this article, we report a 49-year-old male patient with a diagnosis of granulomatosis with polyangiitis who developed a life-threatening colonic ulcer due to cytomegalovirus colitis and a shrunken spleen with irregular contours that was detected on abdominal computed tomography. This is a rare case of cytomegalovirus disease in a patient with granulomatosis with polyangiitis and splenic necrosis. Read More

Transplantation 2020 Feb;104(2):404-409

Transplant Infectious Diseases, University Health Network, Toronto, ON, Canada.

Background: Letermovir, a new viral terminase complex inhibitor, has been approved for the prevention of cytomegalovirus (CMV) infection in hematopoietic stem cell transplant patients. However, data on the efficacy and safety of letermovir for the treatment of CMV infection in transplant recipients remain scarce.

Methods: We performed a single-center retrospective study of stem cell and organ transplant recipients who received letermovir for the treatment of CMV infection from November 2017 to October 2018. Read More

J Formos Med Assoc 2020 Jan 20. Epub 2020 Jan 20.

Division of Hepatology and Gastroenterology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Inflammatory Bowel Disease Clinical and Study Integrated Center, National Taiwan University Hospital, Taipei, Taiwan; College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Cardiol Young 2020 Mar 24;30(3):431-432. Epub 2020 Jan 24.

Department for Pediatric Cardiology, Kepler University Hospital GmbH, Johannes Kepler University Linz, Linz, Austria.

Introduction: Aetiology of protein-losing enteropathy in single-ventricle type CHD is multi-factorial.

Report: We describe two Fontan patients with protein-losing enteropathy who presented with cytomegalovirus-associated colitis.

Discussion: Fontan patients display risk factors for cytomegalovirus-induced gastroenteropathy that may affect lymph angiogenesis, disease development, and progression. Read More

Scand J Gastroenterol 2020 Jan 9;55(1):55-61. Epub 2020 Jan 9.

Department of Gastroenterology, Children's Hospital of Fudan University, Shanghai, China.

Cytomegalovirus (CMV) is rarely thought to be the cause of significant gastrointestinal infection in immunocompetent children. CMV colitis is seldom observed in young infants. This study aims to examine the clinical features of CMV colitis in Chinese children. Read More

Open Forum Infect Dis 2019 Dec 18;6(12):ofz526. Epub 2019 Dec 18.

Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Background: The precise role of cytomegalovirus (CMV) in ulcerative colitis (UC) remains disputed. We evaluated the association of CMV-specific host immune responses and systemic or local viral replication with responses to systemic steroids in patients with moderate to severe UC.

Methods: Patients who were hospitalized for moderate to severe UC between April 2015 and June 2016 were enrolled. Read More

J Thorac Oncol 2020 01;15(1):e15-e20

Department of Gastrointestinal Oncology, Netherlands Cancer Institute, Amsterdam, The Netherlands.

JGH Open 2019 Dec 5;3(6):525-531. Epub 2019 Jul 5.

Department of Gastroenterology Tokyo Women's Medical University Tokyo Japan.

Background And Aim: Combined therapy with tacrolimus (TAC) and an anti-tumor necrosis factorα (TNFα) antibody is used to induce remission in ulcerative colitis (UC) patients who have not responded to monotherapy with either drug. We evaluated the efficacy and safety of combined therapy, as well as the relapse rate.

Methods: Combined therapy was performed to induce remission in UC patients showing an inadequate response to monotherapy with TAC or an anti-TNFα antibody. Read More

ACG Case Rep J 2019 Oct 18;6(10):e00225. Epub 2019 Oct 18.

Department of Gastroenterology, LSU School of Medicine, New Orleans, LA.

Patients with poorly controlled human immunodeficiency virus are subject to a wide range of opportunistic infections. is a parasitic gastrointestinal infection associated with chronic and life-threatening diarrhea in patients with acquired immunodeficiency syndrome. Cytomegalovirus colitis is a serious complication caused by reactivation of the virus, leading to viremia and end-organ disease by hematogenous spread. Read More

Pediatr Blood Cancer 2020 03 2;67(3):e28101. Epub 2019 Dec 2.

Department of Pediatrics, Seoul National University College of Medicine, Seoul, Korea.

Background: Cytomegalovirus (CMV) disease is underrecognized in children with retinoblastoma. This study investigated rates of CMV infection and disease in this specific population receiving chemotherapy.

Methods: From a cohort of 164 patients with retinoblastoma diagnosed from 2011 to 2018, 107 patients were evaluated for CMV infection determined by antigenemia assay or real-time PCR. Read More

Clin Case Rep 2019 Nov 18;7(11):2252-2253. Epub 2019 Sep 18.

Department of Internal Medicine Miyazaki Prefectural Nobeoka Hospital Miyazaki Japan.

Longitudinal mucosal and submucosal hemorrhage along the taeniae coli is a potential colonic manifestation of cytomegalovirus infection in immunocompromised patients. When diagnosing cytomegalovirus colitis in immunocompromised patients, endoscopic biopsy on taeniae coli seems effective for viral detection. Read More

Breast Cancer 2020 Jul 26;27(4):776-779. Epub 2019 Nov 26.

Department of Colorectal Surgery, Taichung Veterans General Hospital, Taichung, Taiwan.

Purpose: Anti-cancer therapy put patients in an immunocompromised status. Reactivation of cytomegalovirus (CMV) in immunocompromised patient can cause a severe disease. Thus, we presented a case who had recurrent CMV colitis which complicate with rectovaginal fistula. Read More

ACG Case Rep J 2019 Sep 2;6(9):e00197. Epub 2019 Sep 2.

Division of Gastroenterology & Hepatology, Department of Medicine, Tufts Medical Center, Boston, MA.

Cecal bascule is a rare type of volvulus of the colon and requires a mobile cecum and ascending colon, which could be due to congenital or acquired anatomic abnormalities. Inflammatory conditions that cause acute changes in colonic mobility or motility may contribute to development of volvulus, as described in other types of colonic obstruction. Patients with risk factors for a mobile proximal colon presenting with obstructive symptoms should undergo prompt diagnostic evaluation for volvulus to allow for timely intervention. Read More

Scand J Gastroenterol 2019 Nov 13;54(11):1346-1352. Epub 2019 Nov 13.

Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji, Istanbul Medeniyet Universitesi, Istanbul, Turkey.

This meta-analysis aimed to pool available data regarding the efficacy of ganciclovir treatment among cytomegalovirus-detected ulcerative colitis patients. We screened PubMed, Ovid, Web of Science and Cochrane databases for relevant studies, and four investigators independently evaluated the studies for eligibility. The primary outcome was surgical resection or death from ulcerative colitis. Read More

Inflammation 2020 Feb;43(1):326-335

Department of Pharmacy, Beijing Chao-Yang Hospital, Capital Medical University, 8 Gongren Tiyuchang Nanlu, Beijing, 100020, China.

Many studies have demonstrated an association between cytomegalovirus (CMV) infection and inflammatory bowel disease (IBD). Moreover, CMV infection is more common in patients with severe or steroid-refractory IBD. However, it is not clarified whether CMV worsens IBD or if it is merely a surrogate marker for IBD. Read More

Pathogens 2019 Nov 4;8(4). Epub 2019 Nov 4.

Institute of Parasitology of Slovak Academy of Sciences, Hlinkova 3, 040 01 Košice, Slovakia.

The HIV/acquired immunodeficiency syndrome (AIDS) pandemic has affected the health status of the population in many countries. Early symptomatic HIV infection includes persistent generalized lymphadenopathy (PGL), which can be associated with opportunistic infections, e.g. Read More

Am J Clin Pathol 2020 02;153(3):380-386

Department of Pathology and Laboratory Medicine, University of Texas Health Science Center at San Antonio.

Objectives: To characterize the histopathologic features of colitis in patients with impaired renal function.

Methods: We retrospectively identified 413 patients who underwent colonoscopic evaluation for colitis between 2011 and 2015. Patients were divided into four groups based on estimated glomerular filtrate rates. Read More

Intern Med 2020 Feb 24;59(4):519-525. Epub 2019 Oct 24.

Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan.

A 64-year-old Japanese man suffered cardiopulmonary arrest, which may have resulted from sepsis and/or hyperosmolar hyperglycemic non-ketonic coma, and was admitted after successful resuscitation. He had watery diarrhea on day 18 and was diagnosed with cytomegalovirus enterocolitis. In addition, computed tomography performed on day 27 and colonoscopy revealed gastric emphysema and intestinal pseudolipomatosis, respectively. Read More

Cir Cir 2019 ;87(6):688-691

Servicio de Cirugía General y del Aparato Digestivo. Complejo Hospitalario Universitario Insular Materno-Infantil de Gran Canaria, Las Palmas, España.

Cytomegalovirus infection is an uncommon illness that mainly affects immunocompromised subjects being associated with high morbidity and mortality rates. Reactivation or reinfection of the virus causes various symptoms ranging from asymptomatic forms to severe organ-specific complications, such as severe lower gastrointestinal bleeding. Once diagnosed the infection it is important and necessary to establish an adequate treatment with antivirals, with the surgical option for those cases with gastrointestinal complications depending on the patients clinical situation. Read More

Turk J Gastroenterol 2019 10;30(10):932-934

Department of Colorectal Surgery, Santa Elena Clinic, Madrid, Spain.

Hematol Transfus Cell Ther 2020 Jan - Mar;42(1):18-24. Epub 2019 Feb 22.

Facultad de ciencias de la salud, Universidad Icesi, Cali, Colombia; Fundación Valle del Lili, Cali, Colombia. Electronic address:

Objective: Cytomegalovirus infection and disease are significant causes of morbidity and mortality among patients with hematopoietic stem cell transplantation. The aim of this study was to assess the frequency of cytomegalovirus infection and characterize the patients who developed the disease.

Methods: A retrospective cohort study was performed among adult patients, recipients of allogeneic HSTC between 2008 and 2015. Read More

Arch Dis Child Fetal Neonatal Ed 2020 May 15;105(3):334-339. Epub 2019 Oct 15.

Department of Paediatric Infectious Diseases, St Mary's Hospital, Imperial College NHS Healthcare Trust, London, U.K.

Postnatal cytomegalovirus (pCMV) infection is a common viral infection typically occurring within the first months of life. pCMV refers to postnatal acquisition of CMV rather than postnatal manifestations of antenatal or perinatal acquired CMV. pCMV is usually asymptomatic in term infants, but can cause symptomatic disease in preterm (gestational age <32 weeks) and very low birth weight (<1500 g) infants resulting in sepsis, pneumonia, thrombocytopaenia, neutropaenia, hepatitis, colitis and occasionally death. Read More

BMJ Case Rep 2019 Oct 13;12(10). Epub 2019 Oct 13.

Clinical Laboratory, Hospital Universitario de Fuenlabrada, Fuenlabrada, Spain.

A follow-up blood count was performed on a 74-year-old woman diagnosed with colitis due to cytomegalovirus and under treatment with valganciclovir. The automated complete blood count revealed an abnormal white blood cells (WBC) scattergram together with WBC alert flags. The peripheral blood smear showed neutrophils with markedly hyposegmented nuclei or bilobed nuclei and very condensed chromatin or clumping chromatin all consistent with Pelger-Huët anomaly (PHA). Read More

Clin Gastroenterol Hepatol 2020 Jul 11;18(8):1785-1795.e3. Epub 2019 Oct 11.

All Wales Lymphoma Panel, University Hospital of Wales, Cardiff, United Kingdom. Electronic address:

Background & Aims: Cancer therapy with immune checkpoint inhibitors can cause colitis and colon perforation. We investigated whether infection with Epstein Barr virus (EBV) associates with development and severity of colitis in patients receiving immune checkpoint inhibitor therapies.

Methods: We performed a retrospective analysis of fixed colon tissues from 16 patients (12 men, 4 women, median age, 69. Read More

Gut 2019 12 27;68(Suppl 3):s1-s106. Epub 2019 Sep 27.

University Hospital of Wales, Cardiff, UK.

Ulcerative colitis and Crohn's disease are the principal forms of inflammatory bowel disease. Both represent chronic inflammation of the gastrointestinal tract, which displays heterogeneity in inflammatory and symptomatic burden between patients and within individuals over time. Optimal management relies on understanding and tailoring evidence-based interventions by clinicians in partnership with patients. Read More