49,923 results match your criteria Cytomegalovirus


Prediction of Neurodevelopmental Impairment in Congenital Cytomegalovirus Infection by Early Postnatal Magnetic Resonance Imaging.

Neonatology 2020 Jun 3:1-7. Epub 2020 Jun 3.

Department of Pediatrics and Child Health, Nihon University School of Medicine, Tokyo, Japan.

Introduction: Congenital cytomegalovirus infection (CCMVI) may result in neurodevelopmental impairments (NDIs) such as hearing loss, developmental delay, epilepsy, and cerebral palsy. We aimed to investigate the potential for brain magnetic resonance imaging (MRI) to predict NDI in patients with CCMVI.

Methods: We studied infants with CCMVI who were referred to our hospital from April 2010 to October 2018 and underwent a brain MRI within 3 months since birth. Read More

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http://dx.doi.org/10.1159/000508218DOI Listing

Transcriptional activities of human elongation factor-1α and cytomegalovirus promoter in transgenic dogs generated by somatic cell nuclear transfer.

PLoS One 2020 3;15(6):e0233784. Epub 2020 Jun 3.

Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seongbuk-gu, Seoul, Republic of Korea.

Recent advances in somatic cell nuclear transfer (SCNT) in canines facilitate the production of canine transgenic models. Owing to the importance of stable and strong promoter activity in transgenic animals, we tested human elongation factor 1α (hEF1α) and cytomegalovirus (CMV) promoter sequences in SCNT transgenic dogs. After transfection, transgenic donor fibroblasts with the hEF1α-enhanced green fluorescence protein (EGFP) transgene were successfully isolated using fluorescence-activated cell sorting (FACS). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0233784PLOS

Non-primary CMV infection not always innocent. A case-report and literature review.

Acta Clin Belg 2020 Jun 3:1-5. Epub 2020 Jun 3.

Department of Neonatology, Antwerp University Hospital, University of Antwerp , Belgium.

Objectives: Cytomegalovirus (CMV) is the most common infectious cause of congenital malformations. CMV infections are frequently symptomatic in case of a primary infection during pregnancy. Generally, maternal immunity protects the newborn against a symptomatic course of the CMV infection. Read More

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http://dx.doi.org/10.1080/17843286.2020.1773651DOI Listing

Facial cytomegalovirus ulcers in transformed mycosis fungoides.

JAAD Case Rep 2020 Jun 24;6(6):524-527. Epub 2020 Apr 24.

Department of Dermatology, Singapore General Hospital, Singapore.

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http://dx.doi.org/10.1016/j.jdcr.2020.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7256224PMC

Total proctocolectomy with end ileostomy for acute onset of ulcerative colitis during chemoradiotherapy for lung adenocarcinoma (successfully treated by surgery): a case report.

Surg Case Rep 2020 Jun 1;6(1):121. Epub 2020 Jun 1.

Department of General Surgery, Toyohashi Municipal Hospital, 50 Hachiken-nishi, Aotake-cho, Toyohashi, Aichi, 441-8570, Japan.

Background: Ulcerative colitis (UC) developing during chemotherapy is very rare. Here, we describe a case of acute onset during chemoradiotherapy for lung adenocarcinoma, requiring a total proctocolectomy.

Case Presentation: A 52-year-old man was admitted to the hospital for chemoradiotherapy of lung cancer. Read More

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http://dx.doi.org/10.1186/s40792-020-00886-xDOI Listing

[Different viral doses of cytomegalovirus infection in the left and right colons].

Zhonghua Bing Li Xue Za Zhi 2020 Jun;49(6):583-587

Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

To compare the differences in the detection rates of cytomegalovirus (CMV) infection between the left and right colons for guiding endoscopic biopsy-sites. The cases of colonic CMV infection confirmed by histology at the Peking Union Medical College Hospital from July 2015 to July 2018 were collected and analyzed. Splenic curvature was used as the dividing point between the left and right colons. Read More

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http://dx.doi.org/10.3760/cma.j.cn112151-20190924-00523DOI Listing

Human Cytomegalovirus-Encoded G Protein-Coupled Receptor UL33 Facilitates Virus Dissemination via the Extracellular and Cell-to-Cell Route.

Viruses 2020 May 30;12(6). Epub 2020 May 30.

Amsterdam Institute for Molecular and Life Sciences (AIMMS), Division of Medicinal Chemistry, Faculty of Sciences, Vrije Universiteit, De Boelelaan 1108, 1081 HZ Amsterdam, The Netherlands.

Human cytomegalovirus (HCMV) encodes four G protein-coupled receptor (GPCR) homologs. Three of these receptors, UL78, US27 and US28, are known for their roles in HCMV dissemination and latency. Despite importance of its rodent orthologs for viral replication and pathogenesis, such a function is not reported for the HCMV-encoded GPCR UL33. Read More

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http://dx.doi.org/10.3390/v12060594DOI Listing

Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus.

Microorganisms 2020 May 30;8(6). Epub 2020 May 30.

Institute for Virology and Forschungszentrum für Immuntherapie, University Medical Center of the Johannes Gutenberg-University Mainz, Obere Zahlbacher Str. 67, D-55131 Mainz, Germany.

The assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that requires, as an essential prerequisite, the complex crosstalk between viral structural proteins. Currently, however, the mechanisms governing the successive steps in the constitution of virion protein complexes remain elusive. Protein phosphorylation is a key regulator determining the sequential changes in the conformation, binding, dynamics, and stability of proteins in the course of multiprotein assembly. Read More

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http://dx.doi.org/10.3390/microorganisms8060820DOI Listing

(Iso)Quinoline-Artemisinin Hybrids via Click Chemistry: Highly Potent Agents against Viruses.

Chemistry 2020 Jun 2. Epub 2020 Jun 2.

Institut für Organische Chemie, Friedrich-Alexander Universität Erlangen-Nürnberg, Department Chemie und Pharmazie, Henkestrasse 42, 91054, Erlangen, GERMANY.

Viral infections cause life-threatening diseases in millions of people worldwide every year and there is urgent need for new effective antiviral drugs. Hybridization of two chemically diverse compounds into a new bioactive effector product is a successful concept to improve the hybrid drug's properties compared to its parent compounds. In this study, (iso)quinoline-artemisinin hybrids, obtained via copper-catalyzed azide-alkyne cycloaddition (CuAAC) or organocatalyzed click reactions (in organic solvents or in the presence of water), were analyzed in vitro for the first time for their inhibitory activity against human cytomegalovirus (HCMV), as compared with their parent compounds and the reference drug ganciclovir. Read More

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http://dx.doi.org/10.1002/chem.202001803DOI Listing

A Comparative Quantitative Proteomic Analysis of HCMV-Infected Cells Highlights pUL138 as a Multifunctional Protein.

Molecules 2020 May 28;25(11). Epub 2020 May 28.

State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.

Human cytomegalovirus (HCMV) is a widespread virus that can establish life-long latent infection in large populations. The establishment of latent infection prevents HCMV from being cleared by host cells, and HCMV reactivation from latency can cause severe disease and death in people with immature or compromised immune systems. To establish persistent and latent infection in healthy individuals, HCMV encodes a large array of proteins that can modulate different components and pathways of host cells. Read More

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http://dx.doi.org/10.3390/molecules25112520DOI Listing

Clinical consequences of primary CMV infection after renal transplantation: a case-control study.

Transpl Int 2020 Jun 1. Epub 2020 Jun 1.

Renal Transplant Unit, Department of Internal Medicine.

Background: The impact of primary cytomegalovirus-infection (pCMV) on renal allograft-function and histology is controversial. We evaluated the influence on incidence of acute-rejection, allograft-loss, allograft-function and interstitial-fibrosis/tubular-atrophy (IF/TA).

Methods: Retrospective case-control study; recipients transplanted between 2000-2014. Read More

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http://dx.doi.org/10.1111/tri.13667DOI Listing

Beyond HIV infection: neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases.

Virus Res 2020 May 29:198040. Epub 2020 May 29.

Laboratório de Imunobiologia e Imunogenética, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil; Programa de Pós-Graduação em Genética e Biologia Molecular, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil; Núcleo de Bioinformática do Laboratório de Imunobiologia e Imunogenética, Departamento de Genética, Universidade Federal do Rio Grande do Sul - UFRGS, Porto Alegre, Brazil. Electronic address:

The interactions between chemokine receptors and their ligands may affect susceptibility to infectious diseases as well as their clinical manifestations. These interactions mediate both the traffic of inflammatory cells and virus-associated immune responses. In the context of viral infections, the human C-C chemokine receptor type 5 (CCR5) receives great attention from the scientific community due to its role as an HIV-1 co-receptor. Read More

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http://dx.doi.org/10.1016/j.virusres.2020.198040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7260533PMC

Cytomegalovirus Genotype Distribution among Congenital and Perinatal Infected Patients with CMV-Associated Thrombocytopenia.

Fetal Pediatr Pathol 2020 Jun 1:1-10. Epub 2020 Jun 1.

Department of Pediatrics, Maternal and Child Health Hospital of Hubei Province, Wuhan, China.

We determined the prevalence and relationship of glycoprotein B (gB), glycoprotein N (gN), and glycoprotein H (gH) genotypes of cytomegalovirus (CMV) in CMV-associated thrombocytopenia (CAP). CMV gB, gN, and gH strains were determined by nested PCR and restriction length polymorphism from 24 CAP and 20 asymptomatic CMV infected infants. The order of prevalence was gB1 (70. Read More

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http://dx.doi.org/10.1080/15513815.2020.1765916DOI Listing

NK Cell-Mediated Recall Responses: Memory-Like, Adaptive, or Antigen-Specific?

Front Cell Infect Microbiol 2020 14;10:208. Epub 2020 May 14.

Department of Dermatology, Medical University of Vienna, Vienna, Austria.

Mounting experimental evidence hints to an import role for natural killer (NK) cells in adaptive immune responses to pathogens. NK cells with adaptive features are heterogeneous and belong to different subsets according to their phenotype as well as the nature of their adaptive recall reactions. Three types of adaptive NK cell responses have been described: (i) NK cells with long-lived memory of multiple different haptens and viral antigens were described in murine liver tissue with a possible human counterpart; (ii) infection of human and mouse cytomegalovirus is associated with an expansion of NKG2C and Ly49H NK cells, respectively, that selectively recognize CMV-encoded peptides thereby facilitating recall responses; (iii) cytokine-stimulated NK cells respond to different stimuli with enhanced production of IFN-γ after re-stimulation. Read More

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http://dx.doi.org/10.3389/fcimb.2020.00208DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7240046PMC

Cytomegaloviruses and Macrophages-Friends and Foes From Early on?

Front Immunol 2020 12;11:793. Epub 2020 May 12.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Starting at birth, newborn infants are exposed to numerous microorganisms. Adaptation of the innate immune system to them is a delicate process, with potentially advantageous and harmful implications for health development. Cytomegaloviruses (CMVs) are highly adapted to their specific mammalian hosts, with which they share millions of years of co-evolution. Read More

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http://dx.doi.org/10.3389/fimmu.2020.00793DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7235172PMC

[Viral co-infection with head and neck tumors].

Vestn Otorinolaringol 2020 ;85(2):67-72

Tomsk National Research Medical Center of the Russian Academy of Sciences, Oncology Research Institute, Tomsk, Russia.

The review is devoted to assessing the prevalence of human papillomavirus (HPV) in combination with other viral agents for head and neck tumors (HNT). HPV is recognized as an etiological factor in the development of cervical cancer, but there is evidence that it may be involved in carcinogenesis in other locations, in particular the upper respiratory tract. However, HPV is not the most important factor in tumor growth and progression. Read More

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http://dx.doi.org/10.17116/otorino20208502167DOI Listing
January 2020

Cytomegalovirus in Solid Organ Transplant Recipients: Clinical Updates, Challenges and Future Directions.

Curr Pharm Des 2020 May 31. Epub 2020 May 31.

Division of Infectious Diseases, William J von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, 200 First Street SW, Rochester, Minnesota 55905. United States.

Cytomegalovirus is the classic opportunistic infection after solid organ transplantation. This review will discuss updates and future directions in the diagnosis, prevention and treatment of CMV infection in solid organ transplant recipients. Antiviral prophylaxis and pre-emptive therapy are the mainstays of CMV prevention, but they should not be mutually exclusive and each strategy should be considered depending on a specific situation. Read More

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http://dx.doi.org/10.2174/1381612826666200531152901DOI Listing

Differential cleavage of viral polypeptides by allotypic variants of granzyme B skews immunity to mouse cytomegalovirus.

Biochim Biophys Acta Proteins Proteom 2020 May 27:140457. Epub 2020 May 27.

Rosie Lew Cancer Immunology Program, Peter MacCallum Cancer Centre, 305 Grattan Street Melbourne 3000, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne 3050, Australia. Electronic address:

We investigated the molecular basis for the remarkably different survival outcomes of mice expressing different alloforms of the pro-apoptotic serine protease granzyme B to mouse cytomegalovirus infection. Whereas C57BL/6 mice homozygous for granzyme B (GzmB) raise cytotoxic T lymphocytes that efficiently kill infected cells, those of C57BL/6 mice congenic for the outbred allele (GzmB) fail to kill MCMV-infected cells and died from uncontrolled hepatocyte infection and acute liver failure. We identified subtle differences in how GzmB and GzmB activate cell death signalling - both alloforms predominantly activated pro-caspases directly, and cleaved pro-apoptotic Bid poorly. Read More

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http://dx.doi.org/10.1016/j.bbapap.2020.140457DOI Listing

Murine cytomegalovirus dissemination but not reactivation in donor-positive/recipient-negative allogeneic kidney transplantation can be effectively prevented by transplant immune tolerance.

Kidney Int 2020 Feb 21. Epub 2020 Feb 21.

Nephrology, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA; Duke Transplant Center, Duke University Medical Center, Durham, North Carolina, USA. Electronic address:

Cytomegalovirus (CMV) reactivation from latently infected donor organs post-transplantation and its dissemination cause significant comorbidities in transplant recipients. Transplant-induced inflammation combined with chronic immunosuppression has been thought to provoke CMV reactivation and dissemination, although sequential events in this process have not been studied. Here, we investigated this process in a high-risk donor CMV-positive to recipient CMV-negative allogeneic murine kidney transplantation model. Read More

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http://dx.doi.org/10.1016/j.kint.2020.01.034DOI Listing
February 2020

Human cytomegalovirus infection is correlated with atherosclerotic plaque vulnerability in carotid artery.

J Gene Med 2020 May 28:e3236. Epub 2020 May 28.

Central Laboratory, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, China.

Objective: Several studies have suggested that human cytomegalovirus (CMV) infection is closely related to the pathogenesis of atherosclerosis. The objective of this study is to investigate the association between human CMV infection and carotid atherosclerotic plaque vulnerability in Chinese population.

Methods: A total of 42 patients with carotid atherosclerosis (observation group) and 30 healthy volunteers (control group) were recruited in our study from October 2016 to January 2018. Read More

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http://dx.doi.org/10.1002/jgm.3236DOI Listing

Cytomegalovirus Proctitis in a Patient with Chronic Lymphocytic Leukemia on Ibrutinib Therapy: A Case Report.

Cureus 2020 Apr 26;12(4):e7837. Epub 2020 Apr 26.

Gastroenterology, University of Illinois College of Medicine at Peoria - OSF Saint Francis Medical Center, Peoria, USA.

Ibrutinib is a Bruton tyrosine kinase (BTK) inhibitor that has shown significant efficacy in patients with lymphoid carcinomas, mostly chronic lymphocytic leukemia (CLL). Cytomegalovirus (CMV) infection is not a common infectious complication associated with ibrutinib. To increase the clinical awareness about this rare entity, we present the first case of CMV proctitis in an immunocompromised host who was being treated with ibrutinib. Read More

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http://dx.doi.org/10.7759/cureus.7837DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7250520PMC

Association between cytomegalovirus end-organ diseases and moderate-to-severe dementia: a population-based cohort study.

BMC Neurol 2020 May 28;20(1):216. Epub 2020 May 28.

Division of Infectious Disease, Department of Internal Medicine, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul, 06273, Republic of Korea.

Background: The association between cytomegalovirus (CMV) and dementia remains controversial. Previous studies have suggested that CMV serostatus, as assessed by serum immunoglobulin G, plays a role in neurodegeneration with cognitive impairment. We aimed to evaluate the association between CMV tissue-invasive end-organ diseases and moderate-to-severe dementia. Read More

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http://dx.doi.org/10.1186/s12883-020-01776-3DOI Listing

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription.

Microorganisms 2020 May 26;8(6). Epub 2020 May 26.

Institute of Genetics, Technische Universität Braunschweig, 38106 Braunschweig, Germany.

The rapid activation of pattern recognition receptor (PRR)-mediated type I interferon (IFN) signaling is crucial for the host response to infection. In turn, human cytomegalovirus (HCMV) must evade this potent response to establish life-long infection. Here, we reveal that the HCMV tegument protein UL35 antagonizes the activation of type I IFN transcription downstream of the DNA and RNA sensors cGAS and RIG-I, respectively. Read More

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http://dx.doi.org/10.3390/microorganisms8060790DOI Listing

Fractalkine/CX3CL1 in Neoplastic Processes.

Int J Mol Sci 2020 May 25;21(10). Epub 2020 May 25.

Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72 Av., 70-111 Szczecin, Poland.

Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma. This work focuses on the 'hallmarks of cancer' involving CX3CL1 and its receptor CX3CR1. Read More

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http://dx.doi.org/10.3390/ijms21103723DOI Listing

Risk of Symptomatic Infection after Non-Primary Congenital Cytomegalovirus Infection.

Microorganisms 2020 May 25;8(5). Epub 2020 May 25.

Neonatal Care Unit, Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.

Cytomegalovirus (CMV) is the leading cause of congenital infection. Its occurrence is phenotypically heterogeneous. The type of maternal infection, primary or non-primary, is an important factor related to the symptomatic disease, the primary infection was long considered the only cause of severe neonatal disease. Read More

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http://dx.doi.org/10.3390/microorganisms8050786DOI Listing

Dissection of the HCMV-Specific Antibody Responses in Lung-Transplant Recipients.

J Heart Lung Transplant 2020 Apr 30;39(4S):S83. Epub 2020 Mar 30.

Center for Virology, Medical University Vienna, Vienna, Austria.

Purpose: Human Cytomegalovirus (HCMV) is an important viral pathogen in lung-transplant recipients (LTRs), which may cause generalized infection and tissue-invasive disease. The risk for HCMV-replication depends on the donor (D) and recipient (R) serostatus as well as on HCMV-specific immune responses such as HCMV-specific antibodies (AB) and NK-cells, which may limit viral spread after lung-transplantation. In this study we analyzed the glycoprotein B (gB) and pentameric complex (PC)-specific AB-responses as well as the antibodies' neutralizing and NK-cell activating effector functions following lung transplantation. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1309DOI Listing

Targeting Latent Human Cytomegalovirus (CMV) with a Novel Fusion Toxin Protein during Ex Vivo Lung Perfusion.

J Heart Lung Transplant 2020 Apr 30;39(4S):S83. Epub 2020 Mar 30.

Latner Thoracic Surgery Research Laboratories, University Health Network, University of Toronto, Toronto, ON, Canada.

Purpose: Donor to recipient CMV mismatch leads to high incidence of CMV infection post lung transplant leading to inferior long-term patient outcomes. CMV latently infected cells ubiquitously express a surface marker, US28. We aimed to evaluate the therapeutic effects of a novel fusion toxin protein (F49A-FTP) that targets US28 in human lungs during EVLP, with the ultimate goal of minimizing or preventing CMV reactivation post transplantation. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1310DOI Listing

Correlation of Longitudinal Gene-Expression Profiling (GEP) Score to Cytomegalovirus (CMV) Infection: Results from the Outcomes Allomap® Registry.

J Heart Lung Transplant 2020 Apr 30;39(4S):S83-S84. Epub 2020 Mar 30.

Cedars Sinai, Beverly Hills, CA.

Purpose: Cytomegalovirus (CMV) infection has been implicated in the pathogenesis of allograft rejection, which is reflected by high gene-expression profiling (GEP) scores. The effect of CMV infection on serial GEP scores in the absence of acute cellular rejection (ACR) is unknown.

Methods: Data from 14,985 samples collected from 2288 heart transplant (HT) recipients enrolled in Outcomes AlloMap® Registry (OAR) were analyzed. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1311DOI Listing

A Potential Role for NKG2C+ γδ T Cells as a Cellular Therapy in Combating Post-Lung Transplant Cytomegalovirus Infection.

J Heart Lung Transplant 2020 Apr 30;39(4S):S82. Epub 2020 Mar 30.

Lung Transplant Service, The Alfred Hospital, Melbourne, Australia.

Purpose: Cytomegalovirus (CMV) is the most clinically significant pathogen following lung transplantation (LTx). While currently used anti-viral treatments are efficacious, their use is associated with toxicity and antiviral resistance. Given early promising results, immunotherapy is an attractive option to complement current antiviral therapies. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1307DOI Listing

Impact of Human HLA-E and NKG2C Variants and of HCMV Ul40 Genotype Populations on HCMV Replication in Lung Transplant Recipients.

J Heart Lung Transplant 2020 Apr 30;39(4S):S82-S83. Epub 2020 Mar 30.

Center for Virology, Medical University Vienna, Vienna, Austria.

Purpose: Human Cytomegalovirus (HCMV) is an important viral pathogen in lung-transplant recipients (LTRs), which may cause tissue-invasive disease. The risk for HCMV-replication depends on HCMV-specific immune responses, which may limit viral spread after lung-transplantation. NKG2C Natural-Killer (NK-) cells limit HCMV replication, even under immunosuppressive therapy. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1308DOI Listing

Cytomegalovirus Immune Globulin (CMV-Ig): An Old Drug with Fewer Tricks - Removal of Prophylactic CMV-Ig Administration in CMV Mismatched Lung Transplant Recipients.

J Heart Lung Transplant 2020 Apr 30;39(4S):S505. Epub 2020 Mar 30.

Medicine, Houston Methodist Hospital, Houston, TX.

Purpose: The routine use of cytomegalovirus immune globulin (CMV-Ig) to provide passive immunity to cytomegalovirus (CMV) in patients is not supported in published literature. International guidelines do not advocate for the use of CMV-Ig alone in thoracic transplant and provide only weak recommendations for its role in combination with antiviral therapy for prevention of CMV. The utilization of CMV-Ig incurs significant cost, and carries the potential for infusion related toxicities. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.109DOI Listing

Incidence and Risk Factors for Neutropenia in Adult Heart Transplant Recipients: Single Centre Experience.

J Heart Lung Transplant 2020 Apr 30;39(4S):S503. Epub 2020 Mar 30.

Royal Brompton & Harefield NHS Foundation Trust, London, United Kingdom.

Purpose: Neutropenia, a major complication of solid organ transplantation, is associated with poorer clinical outcomes. It has frequently been attributed to drug-induced bone marrow suppression and infections. Neutropenia in adult heart transplant recipients are increasingly observed, but little has been published on the burden of post-transplant neutropenia in this population. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.104DOI Listing

Lung Transplantation after Allogeneic Stem Cell Transplantation: A Single-Centre Experience.

J Heart Lung Transplant 2020 Apr 30;39(4S):S501. Epub 2020 Mar 30.

Dept. Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, Padova, Italy.

Purpose: Pulmonary chronic graft versus host disease (GVHD) is one of the thoracic manifestations that can complicate allogeneic hematopoietic stem cell transplantation (HSCT) causing respiratory failure and death. Lung transplantation (LTx) often remains the only therapeutic option for progressive forms although it has been reported in a small number of patients worldwide.

Methods: This retrospective study focused on patients who underwent LTx for pulmonary GVHD in our Centre and consisted in a careful review of all crucial post-transplantation clinical (primary graft dysfunction, CLAD-free survival, overall survival) and pathological data [acute rejection and infection indices in all follow-up scheduled bronchoscopies (total number of biopsies: 35, total number of bronchoalveolar lavages: 33), signs of chronic rejection]. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.099DOI Listing

Risk Factors of Invasive Fungal Infections in Heart and Lung Transplantation: Systematic Review and Meta-Analysis.

J Heart Lung Transplant 2020 Apr 30;39(4S):S485. Epub 2020 Mar 30.

Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.

Purpose: Invasive fungal infection (IFI) remains one of the most common complications after heart and lung transplantation, which relates to high morbidity and mortality rates. However, risk factors associated with this infection have not been well demonstrated.

Methods: We performed a comprehensive search using Ovid MEDLINE, Ovid Embase, Cochrane database of systematic reviews, and Cochrane central register of a controlled trial. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.050DOI Listing

CMV Viremia after Discontinuation of Valganciclovir Prophylaxis in Lung Transplant Recipients.

J Heart Lung Transplant 2020 Apr 30;39(4S):S485. Epub 2020 Mar 30.

Transplant Pulmonology, Massachusetts General Hospital, Boston, MA.

Purpose: Cytomegalovirus (CMV) remains a significant cause of acute morbidity following lung transplantation, and has been linked to the early onset of chronic allograft rejection. Most lung transplant centers utilize prophylaxis with valganciclovir (VGC) to prevent CMV infection. Long-term VGC therapy can be complicated by adverse side effects that include myelosuppression, leading to early discontinuation. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.049DOI Listing

Utilization of PHS Increased Risk for Transmission of Infectious Disease Donor Organs in Lung Transplantation: One Center's 7-year Experience.

J Heart Lung Transplant 2020 Apr 30;39(4S):S483-S484. Epub 2020 Mar 30.

Massachusetts General Hospital, Boston, MA.

Purpose: Over the past several years 37 to 41% of all deceased donor organs in Region 1 were designated as Public Health Service increased risk for infectious disease transmission compared to 25-27% nationally. Limited by the number of standard donors our Center sought to develop guidelines for utilizing these donors and implement a system for follow-up testing for disease transmission. We reviewed our single-center 7-year experience utilizing PHS donor organs in our lung transplant program. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.045DOI Listing

Comparison of Outcomes in Heart Transplant Recipients Receiving CMV Prophylaxis with CMV IVIG with Valganciclovir versus Valganciclovir Alone.

J Heart Lung Transplant 2020 Apr 30;39(4S):S480. Epub 2020 Mar 30.

Tampa General Hospital, Tampa, FL.

Purpose: Cytomegalovirus (CMV) remains one of the most common opportunistic infections affecting orthotopic heart transplant (OHT) patients, with seronegative (R-) recipients receiving transplants from seropositive donors (D+) being at the highest risk. CMV intravenous immune globulin (CMV IVIG) use for prophylaxis has been limited since the release of valganciclovir (VGC) due to efficacy, infusion-related toxicities, and cost. The ISHLT guidelines for the care of heart transplant recipients state there may be a role for CMV IVIG in high risk (D+/R-) OHT in combination with VCG, but it is not clearly defined. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.034DOI Listing

Hepatitis B Seropositivity is Associated with Increased Cardiac Allograft Vasculopathy after Heart Transplantation.

J Heart Lung Transplant 2020 Apr 30;39(4S):S479. Epub 2020 Mar 30.

Sheba Medical Center and Tel Aviv University, Ramat Gan, Israel.

Purpose: Viral triggers have been implicated in the pathogenesis of cardiac allograft vasculopathy (CAV), the Achilles heel of heart transplantation (HT). Cytomegalovirus is associated with impaired coronary endothelial function, and in pediatric HT patients a variety of viruses, particularly adenovirus, are associated with graft dysfunction or loss. Hepatitis B virus (HBV) is associated with vasculitis and vascular processes in non-HT patients. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.031DOI Listing

Preliminary Results of a Randomized Clinical Trial of Intravenous Immunoglobulin in Solid Organ Recipients with Severe Infection and Secondary Antibody Deficiency.

J Heart Lung Transplant 2020 Apr 30;39(4S):S45-S46. Epub 2020 Mar 30.

Clinical Immunology, Hospital General Universitario Gregorio Marañon, Madrid, Spain.

Purpose: Infection is a cause of death in solid organ transplantation. Secondary antibody deficiency is a risk factor of severe infection in solid organ transplantation. In a multicenter randomized clinical trial we evaluated the efficacy and safety of an intravenous immunoglobulin (IVIG) protocol to decrease the rate of re-infection in solid organ recipients with severe infections and secondary antibody deficiency. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.1216DOI Listing

Prevalence of Acute Cellular Rejection and Its Impact on Survival Post Heart Transplantation in the Contemporary Era.

J Heart Lung Transplant 2020 Apr 30;39(4S):S243. Epub 2020 Mar 30.

National Heart and Lung Transplant Centre, Mater Misericordiae University Hospital, Dublin, Ireland.

Purpose: Identify the prevalence and associates of ISHLT grade ≥2R acute cellular rejection (≥2CR) and its impact on survival post heart transplantation in a well-phenotyped, modern era Irish cohort all of whom receive induction therapy.

Methods: Retrospective analysis of 88 patients who underwent heart transplantation between 2014 and 2019 (mean age 49.8 ± 13. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.920DOI Listing

Cytomegalovirus Infections are Frequent after Heart Transplantation but Do Not Increase the Risk of Biopsy-Proven Allograft Rejection in the Modern Era.

J Heart Lung Transplant 2020 Apr 30;39(4S):S205. Epub 2020 Mar 30.

Groupe Hospitalier Pitié-Salpêtrière, Paris, France.

Purpose: Our aim was to analyze the clinical impact of CMV infections on the risk of allograft rejection.

Methods: We conducted a single-center retrospective study including patients transplanted between January 2012 and December 2016 who had at least one endomyocardial biopsy (EMB) during follow-up. Patients at high risk of CMV infections (D+/R-) received valganciclovir prophylaxis for 3 months, those at intermediate risk (R +) were treated according to a preemptive strategy (viral replication threshold: 10,000 IU / mL). Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.819DOI Listing

6-month vs 12-month CMV Prophylaxis for CMV-Mismatched Heart Transplant Recipients.

J Heart Lung Transplant 2020 Apr 30;39(4S):S204-S205. Epub 2020 Mar 30.

Infectious Diseases & Geographic Medicine, Stanford University, Stanford, CA.

Purpose: Cytomegalovirus (CMV) infection frequently affects CMV-mismatched (D+/R-) heart transplant (HTx) recipients. Guidelines recommend 3 to 6 months of CMV prophylaxis for D+/R- HTx recipients. Here we sought to assess the effect of an update to our institution CMV prophylaxis protocol in 2017 with a decreased duration from 12 to 6 months postHTx. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.818DOI Listing

Does CMV Status Impact on Morbidity and Survival Following Heart Transplantation? A Large Multi-Centre Retrospective UK Study.

J Heart Lung Transplant 2020 Apr 30;39(4S):S204. Epub 2020 Mar 30.

Cardiothoracic Transplant Unit, Manchester Foundation Trust, Manchester, United Kingdom.

Purpose: Cytomegalovirus (CMV) infection following heart transplant is associated with increased morbidity and mortality. We evaluated the impact of CMV status on long term survival at all UK centres, employing different approaches to managing CMV.

Methods: Adult patients undergoing heart transplantation and surviving >30 days between March 1987 and August 2018 included. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.817DOI Listing

Natural Killer (NK) Cells: The Missing Link between Antibody-Mediated Rejection (ABMR) and Chronic Lung Allograft Dysfunction (CLAD)?

J Heart Lung Transplant 2020 Apr 30;39(4S):S197. Epub 2020 Mar 30.

Lung Transplant Service, The Alfred Hospital, Melbourne, Australia.

Purpose: The long-term success of lung transplantation (LTx) is limited by CLAD. The complement-independent pathway of ABMR, driven by antibody-dependent cellular cytotoxicity (ADCC) may contribute to CLAD. ADCC is mediated through the CD16 Fc receptor expressed on NK cells, however a role for different NK cell subsets in mediating ABMR is yet to be elucidated. Read More

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http://dx.doi.org/10.1016/j.healun.2020.01.799DOI Listing

Adrenal paracoccidioidomycosis

Biomedica 2020 05 1;40(Supl. 1):20-22. Epub 2020 May 1.

Departamento de Patología, Universidad de Antioquia, Medellín, Colombia.

Primary adrenal insufficiency is a defect in glucocorticoid, mineralocorticoid and sexual androgens production. Patients with this disorder have low cortisol levels and aldosterone deficiency with concomitant hyponatremia and hyperkalemia. The most common etiology of this disease is the production of antibodies against the enzyme 21 hydroxylase. Read More

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http://dx.doi.org/10.7705/biomedica.4844DOI Listing

Cytomegalovirus-associated esophageal stricture as a manifestation of the immune reconstitution inflammatory syndrome.

IDCases 2020 11;21:e00795. Epub 2020 May 11.

Department of Internal Medicine, Chris Hani Baragwanath Academic Hospital, Johannesburg, South Africa.

Cytomegalovirus (CMV) esophagitis is well described in immunocompromised individuals, however, esophageal stricture due to CMV is rare. CMV disease in the setting of the immune reconstitution inflammatory syndrome (IRIS) usually takes the form of an immune-recovery uveitis or retinitis. We describe a young female patient with HIV who developed an esophageal stricture due to CMV within 6 months of starting antiretroviral therapy (ART). Read More

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http://dx.doi.org/10.1016/j.idcr.2020.e00795DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7242862PMC

Timing of primary maternal cytomegalovirus infection and rates of vertical transmission and fetal consequences.

Am J Obstet Gynecol 2020 May 24. Epub 2020 May 24.

Second Department of Obstetrics and Gynecology, Faculty of Medicine, Aristotle University of Thessaloniki, Ippokrateio Hospital of Thessaloniki, Greece. Electronic address:

Objective: Cytomegalovirus (CMV) infection is the most frequent congenital infection and a major cause of long-term neurological morbidity. The aim of this meta-analysis was to calculate the pooled rates of vertical transmission and fetal consequences according to the timing of primary maternal infection.

Data Sources: MEDLINE, Scopus, Cochrane Library and grey literature sources were searched from inception until January 2020. Read More

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http://dx.doi.org/10.1016/j.ajog.2020.05.038DOI Listing

Viral Infections in Burns.

Surg Infect (Larchmt) 2020 May 27. Epub 2020 May 27.

Walter Reed National Military Medical Center, Bethesda, Maryland, USA.

Viral infections after burns are less common than bacterial infections but usually occur in the more severely burned patients and have been associated with poor outcomes. Retrospective reviews and case series were examined to provide an overview of the management of viral infections in the burn patient. The most common viral pathogens in these patients are the herpesviruses, which include herpes simplex, varicella zoster, cytomegalovirus, and human herpesvirus 6. Read More

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http://dx.doi.org/10.1089/sur.2020.130DOI Listing

Epstein-Barr virus retinitis in an immunocompromised child: A case report.

Eur J Ophthalmol 2020 May 27:1120672120926855. Epub 2020 May 27.

Department of Ophthalmology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan.

Introduction: The Epstein-Barr virus is a rare causative pathogen identified in the posterior segment. The majority of cases were presented with a serious condition of acute retinal necrosis, and most of these eyes had poor outcomes. The clinical features and effective treatment options for this condition are still unclear. Read More

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http://dx.doi.org/10.1177/1120672120926855DOI Listing

Is it time for routine prenatal serological screening for congenital cytomegalovirus?

Prenat Diagn 2020 May 27. Epub 2020 May 27.

EA Fetus, Paris Descartes Université, Université de Paris, Paris, France.

Congenital CMV infection (cCMV) is the most prevalent congenital infection, main non-genetic cause of sensorineural hearing loss (SNHL) and major cause of neurological disability. Despite the burden of cCMV, no Public Health body recommends universal serology screening in pregnancy. This was explained by gaps in knowledge of epidemiology, diagnosis, prognosis and the absence of any validated treatment. Read More

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http://dx.doi.org/10.1002/pd.5757DOI Listing