48,136 results match your criteria Cytomegalovirus


Diagnostic performance of cytomegalovirus (CMV) immune monitoring with ELISPOT and QuantiFERON-CMV assay in kidney transplantation: A PRISMA-compliant article.

Medicine (Baltimore) 2019 Apr;98(16):e15228

Background: Cytomegalovirus (CMV) infection is part of major infection complications following kidney transplantation. However, more rapid and low-complexity assays are needed for CMV infection. Our study is to investigate the diagnostic efficacy of 2 novel tests, CMV-ELISPOT and QuantiFERON-CMV tests, in CMV DNA viremia and CMV infection following renal transplant. Read More

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http://dx.doi.org/10.1097/MD.0000000000015228DOI Listing

Immune Activation and Microbial Translocation Markers in HIV-Exposed Uninfected Malawian Infants in the First Year of Life.

J Trop Pediatr 2019 Apr 21. Epub 2019 Apr 21.

National Center for Global Health, Istituto Superiore di Sanità, Rome 00161, Italy.

Background: HIV-exposed uninfected (HEU) infants show a high rate of morbidity. We aimed to investigate on biomarkers of immune activation/microbial translocation in HEU infants, evaluating the impact that infections/malnutrition can have on biomarker levels during the first year of life.

Methods: Clinical data of 72 Malawian infants were recorded monthly and correlated with levels of soluble CD14 (sCD14), lipopolysaccharide-binding protein (LBP) and intestinal fatty acid-binding protein (I-FABP), analyzed longitudinally. Read More

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https://academic.oup.com/tropej/advance-article/doi/10.1093/
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http://dx.doi.org/10.1093/tropej/fmz022DOI Listing
April 2019
1 Read

Herpes Virus Infections Other than Cytomegalovirus in the Recipients of Hematopoietic Stem Cell Transplantation.

Infect Dis Clin North Am 2019 Jun;33(2):467-484

City of Hope National Medical Center, 1500 East Duarte Road, Duarte, CA 91010, USA. Electronic address:

This review discusses the epidemiologic and clinical aspects of herpes viruses other than cytomegalovirus in patients who have undergone hematopoietic stem cell transplantation. Read More

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http://dx.doi.org/10.1016/j.idc.2019.02.012DOI Listing

Haploidentical allogeneic hematopoietic stem cell transplantation increases the risk of cytomegalovirus infection in adult patients with acute leukemia.

Transpl Infect Dis 2019 Apr 20:e13096. Epub 2019 Apr 20.

Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, Taiwan.

Background: Owing to the shortage of hematopoietic stem cells from matched sibling donors (MSD) and matched unrelated donors (MUD), the number of patients undergoing haploidentical allogeneic hematopoietic stem cell transplantation (allo-HSCT) has rapidly increased. Despite a comparable overall survival (OS) and leukemia-free survival using this approach, some evidence suggests that haploidentical allo-HSCT recipients have a higher incidence of cytomegalovirus (CMV) infection, though this has not been clearly established.

Methods: This study retrospectively compared the cumulative incidence of CMV DNAemia, 2-year OS, and leukemia-free survival rates in acute leukemia patients with with MSD (n=41), MUD (n=18), and haploidentical donor allografts (n=21). Read More

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http://dx.doi.org/10.1111/tid.13096DOI Listing

Transcripts expressed in cytomegalovirus latency coding for an antigenic IE/E phase peptide that drives "memory inflation".

Med Microbiol Immunol 2019 Apr 19. Epub 2019 Apr 19.

Institute for Virology, University Medical Center, Johannes Gutenberg-University Mainz and Research Center for Immunotherapy (FZI), Obere Zahlbacher Strasse 67, Hochhaus am Augustusplatz, 55131, Mainz, Germany.

Roizman's definition of herpesviral latency, which applies also to cytomegaloviruses (CMVs), demands maintenance of reactivation-competent viral genomes after clearance of productive infection. It is more recent understanding that failure to complete the productive viral cycle for virus assembly and release does not imply viral gene silencing at all genetic loci and all the time. It rather appears that CMV latency is transcriptionally "noisy" in that silenced viral genes get desilenced from time to time in a stochastic manner, leading to "transcripts expressed in latency" (TELs). Read More

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http://link.springer.com/10.1007/s00430-019-00615-8
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http://dx.doi.org/10.1007/s00430-019-00615-8DOI Listing
April 2019
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Function of the cargo sorting dileucine motif in a cytomegalovirus immune evasion protein.

Med Microbiol Immunol 2019 Apr 19. Epub 2019 Apr 19.

Institute for Virology, University Medical Center of the Johannes Gutenberg-University Mainz and Research Center for Immunotherapy (FZI), Obere Zahlbacher Strasse 67, Hochhaus am Augustusplatz, 55131, Mainz, Germany.

As an immune evasion mechanism, cytomegaloviruses (CMVs) have evolved proteins that interfere with cell surface trafficking of MHC class-I (MHC-I) molecules to tone down recognition by antiviral CD8 T cells. This interference can affect the trafficking of recently peptide-loaded MHC-I from the endoplasmic reticulum to the cell surface, thus modulating the presentation of viral peptides, as well as the recycling of pre-existing cell surface MHC-I, resulting in reduction of the level of overall MHC-I cell surface expression. Murine cytomegalovirus (mCMV) was paradigmatic in that it led to the discovery of this immune evasion strategy of CMVs. Read More

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http://link.springer.com/10.1007/s00430-019-00604-x
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http://dx.doi.org/10.1007/s00430-019-00604-xDOI Listing
April 2019
1 Read

Impact of CMV upon immune aging: facts and fiction.

Med Microbiol Immunol 2019 Apr 19. Epub 2019 Apr 19.

Department of Immunobiology and the University of Arizona Center on Aging, University of Arizona College of Medicine-Tucson, Tucson, AZ, 85718, USA.

Aging is accompanied by significant defects in immunity and compromised responses to new, previously unencountered microbial pathogens. Most humans carry several persistent or latent viruses as they age, interacting with the host immune systems for years. In that context maybe the most studied persistent virus is Cytomegalovirus, infamous for its ability to recruit very large T cell responses which increase with age and to simultaneously evade elimination by the immune system. Read More

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http://link.springer.com/10.1007/s00430-019-00605-w
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http://dx.doi.org/10.1007/s00430-019-00605-wDOI Listing
April 2019
1 Read

Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA

Respiratory tract infections due to community-acquired respiratory viruses including respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus are detected in up to 40% of allogeneic hematopoietic stem cell transplant recipients in whom they cause severe symptoms including pneumonia and bronchiolitis and can be fatal. Given the lack of effective antivirals and the data from our group demonstrating that adoptively transferred ex vivo-expanded virus-specific T cells can be clinically beneficial for the treatment of both latent (Epstein-Barr virus, cytomegalovirus, BK virus, human herpesvirus 6) and lytic (adenovirus) viruses, we investigated the potential for extending this immunotherapeutic approach to respiratory viruses. We now describe a system that rapidly generates a single preparation of polyclonal (CD4+ and CD8+) virus-specific T cells reactive against 12 antigens derived from 4 viruses (respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus) that commonly cause post-transplant morbidity and mortality. Read More

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http://dx.doi.org/10.3324/haematol.2018.206896DOI Listing

Toward DNA-Based T-Cell Mediated Vaccines to Target HIV-1 and Hepatitis C Virus: Approaches to Elicit Localized Immunity for Protection.

Front Cell Infect Microbiol 2019 3;9:91. Epub 2019 Apr 3.

Virology Laboratory, Basil Hetzel Institute for Translational Health Research, Discipline of Surgery, University of Adelaide, Adelaide, SA, Australia.

Human immunodeficiency virus (HIV)-1 and hepatitis C virus (HCV) are major contributors to the global disease burden with many experts recognizing the requirement of an effective vaccine to bring a durable end to these viral epidemics. The most promising vaccine candidates that have advanced into pre-clinical models and the clinic to eliminate or provide protection against these chronic viruses are viral vectors [e.g. Read More

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https://www.frontiersin.org/article/10.3389/fcimb.2019.00091
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http://dx.doi.org/10.3389/fcimb.2019.00091DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456646PMC
April 2019
5 Reads

Human Cytomegalovirus Antigen Presentation by HLA-DR+ NKG2C+ Adaptive NK Cells Specifically Activates Polyfunctional Effector Memory CD4+ T Lymphocytes.

Front Immunol 2019 3;10:687. Epub 2019 Apr 3.

Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.

Natural killer (NK) cells play a dual role in the defense against viral pathogens by directly lysing infected cells as well as by regulating anti-viral T cell immunity. Infection by human cytomegalovirus (HCMV) promotes a persistent expansion of NKG2C+ adaptive NK cells which have been shown to display enhanced antibody-dependent responses against infected targets and associated to viral control in transplanted patients. Based on gene expression data showing increased transcription of CIITA and several genes related to the MHC class II pathway in adaptive NK cells, we explored their putative capacity for antigen presentation to CD4+ T cells. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00687DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6456717PMC

Drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS): An update in 2019.

Allergol Int 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Kyorin University School of Medicine, Tokyo, Japan.

The aim of this review was to provide an updated overview of drug-induced hypersensitivity syndrome (DiHS)/drug reaction with eosinophilia and systemic symptoms (DRESS). Several new insights have been made, particularly with regards to the diagnosis, pathogenesis and care of some important complications and sequelae. The indication of herpesvirus reactivations in diagnosis in the assessment of disease severity is now better specified. Read More

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http://dx.doi.org/10.1016/j.alit.2019.03.006DOI Listing

Regulation of human cytomegalovirus secondary envelopment by a C-terminal tetra-lysine motif in pUL71.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

Institute of Virology, Ulm University Medical Center, 89081 Ulm, Germany.

Human cytomegalovirus (HCMV) secondary envelopment requires the viral tegument protein pUL71. Lack of pUL71 results in a complex ultrastructural phenotype with increased numbers of viral capsids undergoing envelopment at the cytoplasmic virus assembly complex. Here, we report a role of the pUL71 C-terminus in secondary envelopment. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.02244-18
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http://dx.doi.org/10.1128/JVI.02244-18DOI Listing
April 2019
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Phenotypic and functional differences between HHV-6 and HCMV specific T-cells.

J Virol 2019 Apr 17. Epub 2019 Apr 17.

INSERM 1135, Centre d'Immunologie et des Maladies Infectieuses (CIMI-Paris), Sorbonne Université, F-75013, Paris, France

: Human herpesvirus 6 (HHV-6) infects over 90% of the population, and establishes a latent infection, with asymptomatic episodes of reactivation. However, HHV-6 reactivation is associated with morbidity and sometimes mortality in immunocompromised patients. To date, the control of the virus in healthy virus carriers and its failure in patients with disease remain poorly understood. Read More

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http://jvi.asm.org/lookup/doi/10.1128/JVI.02321-18
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http://dx.doi.org/10.1128/JVI.02321-18DOI Listing
April 2019
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Early infection with cytomegalovirus and risk of childhood hematological malignancies.

Cancer Epidemiol Biomarkers Prev 2019 Apr 17. Epub 2019 Apr 17.

Institute of Environmental Medicine, Unit of Epidemiology, Karolinska Institute.

Background: Congenital cytomegalovirus (CMV) infection was recently identified as a risk factor for childhood acute lymphocytic leukemia by detecting the presence of CMV sequences in neonatal blood spots. In the current study, we asked whether clinically apparent CMV infection could be identified prior to hematological malignancy, using high quality Swedish population-based registries.

Methods: CMV infection was identified with appropriate ICD-9 or ICD-10 codes in the Patient and Medical Birth Registries, and childhood malignancies below the age of 15 were identified in the Cancer Registry, among 2,782,507 children born in Sweden 1987 to 2014. Read More

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http://dx.doi.org/10.1158/1055-9965.EPI-19-0044DOI Listing
April 2019
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Maternal Viral Infection and Risk of Fetal Congenital Heart Diseases: A Meta-Analysis of Observational Studies.

J Am Heart Assoc 2019 May;8(9):e011264

1 Department of Epidemiology and Health Statistics Xiangya School of Public Health Central South University Hunan China.

Background At present, the association between maternal viral infection and risk of congenital heart diseases ( CHD ) in offspring is uncertain; additionally, a complete overview is missing. A meta-analysis of observational studies was performed to address the question of whether women who had a history of viral infection in early pregnancy were at an increased risk of CHD in offspring, compared with mothers without viral infection. Methods and Results Unrestricted searches were conducted, with an end date parameter of July 15, 2018, of PubMed, Embase, Google Scholar, Cochrane Libraries, and Chinese databases, to identify studies that met prestated inclusion criteria. Read More

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https://www.ahajournals.org/doi/10.1161/JAHA.118.011264
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http://dx.doi.org/10.1161/JAHA.118.011264DOI Listing
May 2019
1 Read

Sequential infection of herpes simplex virus, candida, and cytomegalovirus in esophagus.

Gastrointest Endosc 2019 Apr 14. Epub 2019 Apr 14.

Department of Gastroenterology and Hepatology, Takatsuki Red Cross Hospital, 1-1-1 Abuno, Takatsuki-city, Osaka 569-1045 Japan.

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https://linkinghub.elsevier.com/retrieve/pii/S00165107193159
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http://dx.doi.org/10.1016/j.gie.2019.04.210DOI Listing
April 2019
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Comparison of the LIAISON®XL and ARCHITECT IgG, IgM, and IgG avidity assays for the diagnosis of Toxoplasma, cytomegalovirus, and rubella virus infections.

New Microbiol 2019 Apr 17;41(2). Epub 2019 Apr 17.

SC Microbiologia e Virologia Fondazione IRCCS Policlinico San Matteo Pavia, Italy.

This study compared the performance of the LIAISON®XL system of immunoglobulin (Ig) G and IgM immunoassays for the diagnosis of Toxoplasma gondii, cytomegalovirus (CMV), and rubella virus infections with that of the ARCHITECT system. Patient serum samples, previously screened and clinically diagnosed with T. gondii, CMV or rubella, were used to compare LIAISON®XL and ARCHITECT IgG and IgM immunoassays. Read More

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April 2019
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Epidemiology of viral infections among children undergoing hematopoietic stem cell transplant: Α prospective single- center study.

Transpl Infect Dis 2019 Apr 16:e13095. Epub 2019 Apr 16.

Pediatric Clinic, "P & A Kyriakou" Children's Hospital, National and Kapodistrian University of Athens, Faculty of Nursing, Athens, Greece.

Background: Viral infections are a significant cause of morbidity and mortality in pediatric transplant populations. We analyzed the epidemiology of viral infections in pediatric hematopoietic stem cell transplant (HSCT) patients, including their incidence, associated risk factors, and outcome.

Methods: In a prospective study from September 2011 to September 2015 blood, urine and stool specimens were monitored weekly from transplantation to day 100 or after if clinically suspected, by use of real-time polymerase chain reaction. Read More

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http://dx.doi.org/10.1111/tid.13095DOI Listing
April 2019
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Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach.

Eur J Epidemiol 2019 Apr 13. Epub 2019 Apr 13.

Department of Epidemiology, Harvard T.H. Chan School of Public Health, 677 Huntington Avenue, Boston, MA, 02115, USA.

Chronological age alone is not a sufficient measure of the true physiological state of the body. The aims of the present study were to: (1) quantify biological age based on a physiological biomarker composite model; (2) and evaluate its association with death and age-related disease onset in the setting of an elderly population. Using structural equation modeling we computed biological age for 1699 individuals recruited from the first and second waves of the Rotterdam study. Read More

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http://dx.doi.org/10.1007/s10654-019-00497-3DOI Listing

The prognostic impact of the cytomegalovirus serostatus in patients with chronic hematological malignancies after allogeneic hematopoietic stem cell transplantation: a report from the Infectious Diseases Working Party of EBMT.

Ann Hematol 2019 Apr 16. Epub 2019 Apr 16.

Collegium Medicum UMK, University Hospital, Bydgoszcz, Poland.

It has been shown recently that donor and/or recipient cytomegalovirus (CMV) seropositivity is associated with a significant overall survival (OS) decline in acute leukemia patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT). We now analyzed the prognostic impact of the donor/recipient CMV serostatus in 6968 patients with chronic hematological malignancies who underwent allo-HSCT. Donor and/or recipient CMV seropositivity was associated with a significantly reduced 2-year progression-free survival (PFS, 50% vs. Read More

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http://link.springer.com/10.1007/s00277-019-03669-z
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http://dx.doi.org/10.1007/s00277-019-03669-zDOI Listing
April 2019
1 Read

Cytomegalovirus infection in a T-cell lymphoma patient presenting with multiple gastrointestinal ulcers: a case report.

Endosc Int Open 2019 Apr 12;7(4):E615-E620. Epub 2019 Apr 12.

Department of Gastroenterology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Gastrointestinal ulcers are responsible for a wide spectrum of diseases. Infection, drug-induced enteritis, malignancy, vasculitis and Inflammatory bowel disease are the most common causes; their clinical expression often varies according to the site and severity of intestinal involvement. We report on a 68-year-old male presenting with dyspepsia and melena and multiple gastrointestinal ulcers on endoscopy. Read More

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http://dx.doi.org/10.1055/a-0869-7828DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461553PMC
April 2019
1 Read

Pharmacokinetic Drug-Drug Interactions Between Letermovir and the Immunosuppressants Cyclosporine, Tacrolimus, Sirolimus, and Mycophenolate Mofetil.

J Clin Pharmacol 2019 Apr 16. Epub 2019 Apr 16.

Merck & Co., Inc., Kenilworth, NJ, USA.

Letermovir (AIC246, MK-8228) is a human cytomegalovirus terminase inhibitor indicated for the prophylaxis of cytomegalovirus infection and disease in allogeneic hematopoietic stem cell transplant recipients that is also being investigated for use in other transplant settings. Many transplant patients receive immunosuppressant drugs, of which several have narrow therapeutic ranges. There is a potential for the coadministration of letermovir with these agents, and any potential effect on their pharmacokinetics (PK) must be understood. Read More

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http://dx.doi.org/10.1002/jcph.1423DOI Listing

The Susceptibility of Primary Dermis Fibroblasts from the Chinese Tree Shrew to Human Cytomegalovirus Infection.

Virol Sin 2019 Apr 15. Epub 2019 Apr 15.

Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, 650500, China.

As a universal pathogen leading to neonatal defects and transplant failure, human cytomegalovirus (HCMV) has strict species specificity and this has prevented the development of a suitable animal model for the pathogenesis study. The mechanism of cross-species barrier remains elusive and there are so far no non-human cell culture models that support HCMV replication. The Chinese tree shrew (Tupaia belangeri chinensis) is a small laboratory animal and evolutionary closely related with primates. Read More

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http://dx.doi.org/10.1007/s12250-019-00106-3DOI Listing
April 2019
2 Reads

The hallmarks of CMV-specific CD8 T-cell differentiation.

Med Microbiol Immunol 2019 Apr 13. Epub 2019 Apr 13.

Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.

Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high or even increase over time, a phenomenon named memory T-cell inflation. Besides, the maintained robust T-cell response, CMV-specific T cells seem to have a distinctive phenotype, characterized by an advanced differentiation state. Here, we will review this "special" differentiation status by discussing the cellular phenotype based on the expression of CD45 isoforms, costimulatory, inhibitory and natural killer receptors, adhesion and lymphocyte homing molecules, transcription factors, cytokines and cytotoxic molecules. Read More

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http://link.springer.com/10.1007/s00430-019-00608-7
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http://dx.doi.org/10.1007/s00430-019-00608-7DOI Listing
April 2019
1 Read

Cellular Cullin RING Ubiquitin Ligases: Druggable Host Dependency Factors of Cytomegaloviruses.

Int J Mol Sci 2019 Apr 2;20(7). Epub 2019 Apr 2.

Institute for Virology, University Hospital Essen, University Duisburg-Essen, 45147 Essen, Germany.

Human cytomegalovirus (HCMV) is a ubiquitous betaherpesvirus that frequently causes morbidity and mortality in individuals with insufficient immunity, such as transplant recipients, AIDS patients, and congenitally infected newborns. Several antiviral drugs are approved to treat HCMV infections. However, resistant HCMV mutants can arise in patients receiving long-term therapy. Read More

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https://www.mdpi.com/1422-0067/20/7/1636
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http://dx.doi.org/10.3390/ijms20071636DOI Listing
April 2019
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Is hospital-acquired pneumonia different in transplant recipients?

Clin Microbiol Infect 2019 Apr 12. Epub 2019 Apr 12.

Infectious Diseases Department, Bellvitge University Hospital, IDIBELL, University of Barcelona, Spain; REIPI (Spanish Network for Research in Infectious Disease), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background: Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are serious complications in transplant patients.

Objectives: The aim of this review is to summarize the evidence regarding nosocomial pneumonia in transplant recipients, including HAP in non-ventilated patients and VAP, and to identify future directions for improvement.

Sources: A comprehensive literature search in the PubMed/MEDLINE database was performed. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S1198743X193015
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http://dx.doi.org/10.1016/j.cmi.2019.04.003DOI Listing
April 2019
2 Reads

High incidence of Clinically Significant Cytomegalovirus Infection in CMV D+/R+ Lung Transplant Recipients Receiving 3 Months of Antiviral Prophylaxis.

Transpl Infect Dis 2019 Apr 15:e13094. Epub 2019 Apr 15.

Department of Medicine, Division of Infectious Diseases, University of Alberta, Canada.

Background: Universal antiviral prophylaxis is the preferred preventive strategy for lung transplant recipients (LTRs) at risk of CMV infection. We compared the risk of CMV infection between CMV D+/R+ and D-/R+ LTRs after 3 months of prophylaxis.

Methods: This was a retrospective review of CMV R+ LTRs transplanted between 2005-2013. Read More

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http://dx.doi.org/10.1111/tid.13094DOI Listing

Unusual Presentation of Hemophagocytic Lymphohistiocytosis in a Kidney Transplant Patient.

Case Rep Transplant 2019 10;2019:3682378. Epub 2019 Mar 10.

Division of Nephrology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.

We are presenting a case of a middle-aged woman with history of remote kidney transplantation who had multiple admissions for septic shock-like picture, recurrent fever, and hypotension. Her shock manifestation would resolve after stress dose steroid administration and less than 24 hours of vasopressor administration. Initially, extensive workup was performed without revealing etiology. Read More

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http://dx.doi.org/10.1155/2019/3682378DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431471PMC
March 2019
1 Read

CD28 CD4 T-cell expansions in autoimmune disease suggest a link with cytomegalovirus infection.

F1000Res 2019 25;8. Epub 2019 Mar 25.

Department of Clinical and Experimental medicine, Brighton and Sussex Medical School, Brighton, Sussex, BN1 9PX, UK.

Immunosenescence is thought to contribute to the increase of autoimmune diseases in older people. Immunosenescence is often associated with the presence of an expanded population of CD4 T cells lacking expression of CD28 (CD28 ). These highly cytotoxic CD4 T cells were isolated from disease-affected tissues in patients with rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, or other chronic inflammatory diseases and their numbers appeared to be linked to disease severity. Read More

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http://dx.doi.org/10.12688/f1000research.17119.1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6436193PMC
March 2019
1 Read

Blood donor safety, prevalence and associated factors for cytomegalovirus infection among blood donors in Minna-Nigeria, 2014.

Pan Afr Med J 2019 22;32(Suppl 1). Epub 2019 Jan 22.

Nigeria Field Epidemiology and Laboratory Training Program, Abuja-Nigeria.

Introduction: human cytomegalovirus (CMV) has remained a cause of morbidity and mortality in pregnancy and immunocompromised patients. CMV is transmissible through blood transfusion. We conducted a descriptive, cross-sectional study to assess blood donor safety and to determine the prevalence and associated factors for CMV infection among blood donors in Minna, Nigeria. Read More

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http://dx.doi.org/10.11604/pamj.supp.2019.32.1.13297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6445335PMC

A Practical Review of Cytomegalovirus in Gastroenterology and Hepatology.

Gastroenterol Res Pract 2019 7;2019:6156581. Epub 2019 Mar 7.

Division of Gastroenterology and Hepatology, Scripps Clinic, La Jolla, CA, USA.

Human cytomegalovirus (CMV) is a ubiquitous virus with a wide spectrum of pathology in humans. Host immunity is a major determinant of the clinical manifestation of CMV and can vary widely in the gastroenterology and hepatology practice setting. Immunocompetent patients generally develop a benign, self-limited mononucleosis-like syndrome whereas gastrointestinal tissue-invasive disease is more frequently seen in immunocompromised and inflammatory bowel disease patients. Read More

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https://www.hindawi.com/journals/grp/2019/6156581/
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http://dx.doi.org/10.1155/2019/6156581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431500PMC
March 2019
2 Reads

Very Early Cytomegalovirus Infection After Renal Transplantation: A Single-Center 20-Year Perspective.

Virology (Auckl) 2019 2;10:1178122X19840371. Epub 2019 Apr 2.

Department of Medicine, University of Wisconsin-Madison School of Medicine and Public Health, University of Wisconsin Hospital and Clinics, Madison, WI, USA.

Background: Cytomegalovirus (CMV) infection risk in the first month after transplantation is felt to be minimal; however, the epidemiology has not been specifically investigated, particularly in the modern era of potent immunosuppressive regimens and universal CMV prophylaxis.

Objective: The aim of this study was to describe the incidence of and risk factors associated with CMV occurring less than 30 days after transplant and evaluate the effect of very early CMV on outcomes.

Methods: Retrospective, single-center study of adult renal transplant (RTX) recipients between January 1, 1994 and December 31, 2014. Read More

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http://dx.doi.org/10.1177/1178122X19840371DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6448111PMC

Cytomegalovirus Induced Collapsing Glomerulopathy and Necrotizing Glomerulonephritis in a Renal Allograft Recipient.

Indian J Nephrol 2019 Mar-Apr;29(2):122-124

Department of Pathology, Center for Renal and Urological Pathology, Chennai, Tamil Nadu, India.

In renal allograft recipients, cytomegalovirus (CMV) typically causes tubulointerstitial nephritis. Only rarely glomeruli are involved. We present a rare case of CMV with collapsing glomerulopathy, necrotizing glomerulonephritis, and crescent formation in a renal allograft recipient. Read More

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http://www.indianjnephrol.org/preprintarticle.asp?id=252210
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http://dx.doi.org/10.4103/ijn.IJN_375_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440330PMC
April 2019
2 Reads

[Cytomegalovirus infections].

Rev Prat 2019 Mar;69(3):301-306

CNR des Herpesvirus, laboratoire de bactériologievirologie-hygiène, CHU de Limoges, université de Limoges, Inserm, RESINFIT, U1092, Limoges, France.

Cytomegalovirus infections. Cytomegalovirus (CMV) infections, which are common in children and adolescents, are often asymptomatic or with little specific signs. When they occur in adults, clinical forms may be more severe even in the immunocompetent. Read More

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March 2019
2 Reads

[The ocular manifestations of human immunodeficiency virus and syphilis coinfection].

Zhonghua Yan Ke Za Zhi 2019 Apr;55(4):267-272

Department of Ophthalmology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China.

To investigate the ocular manifestations of human immunodeficiency virus (HIV) and syphilis coinfection. A retrospective analysis of the ocular manifestations was carried out in 27 patients (54 eyes) diagnosed as syphilis and HIV coinfection by the Department of Infectious Medicine in Peking Union Medical College Hospital during the years of 2006-2017. The research included 26 males and 1 female, aging from 24 to 76 years old, with a mean age of 40. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0412-4081.2019.04.008DOI Listing
April 2019
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Maturation of the immune system in the fetus and the implications for congenital CMV.

Best Pract Res Clin Obstet Gynaecol 2019 Mar 16. Epub 2019 Mar 16.

Pediatric Department A and Immunology Service, Jeffrey Modell Foundation Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Affiliated with Tel Aviv University, Tel Aviv 6997801, Israel.

Congenital cytomegalovirus (CMV) infection is the most prevalent and consequential congenital infection, among others, that affects approximately 0.6% of all live births worldwide. Timing of maternal infection and maternal immune status largely determine the likelihood of a symptomatic infection. Read More

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http://dx.doi.org/10.1016/j.bpobgyn.2019.03.002DOI Listing

Wiskott-Aldrich syndrome protein may be critical for CD8 T cell function following MCMV infection.

Cell Immunol 2019 Apr 27;338:43-50. Epub 2019 Mar 27.

Department of Hematology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:

Wiskott-Aldrich syndrome (WAS) patients are characterized by immunodeficiency and viral infections. T cells derived from WAS patients and WAS protein (WASP)-deficient mice have various defects. However, whether WASP plays a role in immune control of cytomegalovirus (CMV) infection remains unclear. Read More

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http://dx.doi.org/10.1016/j.cellimm.2019.03.004DOI Listing
April 2019
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[Infectious complications after kidney transplantation].

Nephrol Ther 2019 Apr;15 Suppl 1:S37-S42

Service de néphrologie et transplantation adulte, hôpital Necker Enfants Malades, Assistance publique-Hôpitaux de Paris, 149, rue de Sèvres, 75015 Paris, France; Université Paris Descartes Sorbonne Paris Cité, 12, rue de l'École-de-Médecine, 75006 Paris, France.

Infectious complications are one of the leading causes of hospitalization and mortality in kidney transplant recipients. They are more frequent during the year following transplantation, and in the elderly. Community infections, such as pyelonephritis and pneumonia, are from far the most common infections. Read More

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http://dx.doi.org/10.1016/j.nephro.2019.03.010DOI Listing
April 2019
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Acute Fulminant-Onset Synchronized CMV-Ulcerative Colitis.

Arch Iran Med 2019 Feb 1;22(2):99-101. Epub 2019 Feb 1.

Tepecik Education and Research Hospital, Department of Gastroenterology, Yenisehir-Izmir, Turkey.

Cytomegalovirus (CMV) is an agent which exists asymptomatically in most individuals and may cause latent life-time infection following contamination. Symptomatic CMV infection develops most commonly in organ transplant recipients and in individuals who receive immunosuppressive drugs, undergo haemodialysis or have acquired immunodeficiency syndrome. The link between ulcerative colitis and CMV infection and the efficacy of antiviral therapy in these individuals have been demonstrated. Read More

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February 2019
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Effects of bariatric surgery on telomere length and T-cell aging.

Int J Obes (Lond) 2019 Apr 12. Epub 2019 Apr 12.

Department of Internal Medicine, Section Nephrology and Transplantation, Erasmus University Medical Center, Rotterdam, The Netherlands.

Background: Obesity adversely affects health and is associated with subclinical systemic inflammation and features of accelerated aging, including the T-cell immune system. The presence of metabolic syndrome (MetS) may accelerate, while bariatric surgery might reverse these phenomena. To examine the effects of MetS and bariatric surgery on T-cell aging, we measured relative telomere length (RTL) and T-cell differentiation status in obese patients before and after bariatric surgery. Read More

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http://www.nature.com/articles/s41366-019-0351-y
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http://dx.doi.org/10.1038/s41366-019-0351-yDOI Listing
April 2019
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Weaponizing T-cell receptors through molecular engineering.

J Biol Chem 2019 Apr;294(15):5805-5806

From the Departments of Biomedical Engineering,

T-cell receptors (TCRs) recognize pathogens to ignite immune responses, making them attractive scaffolds for development as immunotherapeutics. However, manipulation of TCRs has been impeded by difficulties in their engineering and expression. Wagner and colleagues now establish new platforms to generate high-affinity TCR variants that potently activate T cells, and they also create soluble TCR fusion proteins that specifically recognize cognate peptides. Read More

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http://dx.doi.org/10.1074/jbc.H119.008479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463730PMC

Recurrent Aphthous Stomatitis Caused by Cytomegalovirus, Herpes Simplex Virus, and Candida Species in a Kidney Transplant Recipient: A Case Report.

Transplant Proc 2019 Apr 26;51(3):993-997. Epub 2019 Jan 26.

Department of Urology, Kyoto University Hospital, Kyoto, Japan.

Recipients of organ transplants are immunosuppressed and at high risk of oral infection. Oral diseases are often neglected compared with infections of other organs that typically confer higher morbidity. However, severe local symptoms hinder oral intake, decrease quality of life, and are sometimes lethal. Read More

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http://dx.doi.org/10.1016/j.transproceed.2019.01.058DOI Listing
April 2019
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Cytomegalovirus cholestasis in an immunocompetent host.

Ann Biol Clin (Paris) 2019 Apr 12. Epub 2019 Apr 12.

Université Mohammed V, Faculté de médecine et de pharmacie de Rabat, Centre Hospitalier Universitaire Ibn Sina, Hôpital des spécialités, Laboratoire central de virologie, Rabat, Maroc.

Primary infection or reactivation of cytomegalovirus (CMV) can induce in immunocompromised patients a severe disease depending on the type of immuno-suppression, and can affect multiple organs. On the other hand, the infection is benign and mostly asymptomatic in immunocompetent individuals who do not require antiviral treatment. Rare cases of primary infection have been documented. Read More

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http://dx.doi.org/10.1684/abc.2019.1434DOI Listing
April 2019
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Seroepidemiological analysis and literature review of the prevalence of Epstein-Barr virus and herpesvirus infections in pediatric cases with non-Hodgkin lymphoma in Central Europe.

Pediatr Blood Cancer 2019 Apr 12:e27752. Epub 2019 Apr 12.

Department of Pediatric Hematology and Oncology, Justus Liebig University Giessen, Giessen, Germany.

Background: Epstein-Barr virus (EBV) is linked to a variety of malignancies; most endemic Burkitt lymphoma (BL) harbor EBV, whereas only a subset of the cases of sporadic BL is EBV positive.

Procedure: We retrospectively determined the herpesvirus seroprevalence at the time of diagnosis in pediatric non-Hodgkin lymphoma (NHL) patients enrolled in NHL-BFM (Berlin-Frankfurt-Muenster) studies. We accessed the seroepidemiological data from 1147 patients that became available during 1990-2007. Read More

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http://dx.doi.org/10.1002/pbc.27752DOI Listing
April 2019
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No risk factors for late onset hearing loss in asymptomatic congenital cytomegalovirus infants - close monitoring is needed.

Acta Paediatr 2019 Apr 12. Epub 2019 Apr 12.

Department of Pediatrics C, Schneider Children's Medical Center, Petah Tikva, Israel.

Congenital cytomegalovirus (cCMV) is the leading cause of congenital infections, affecting approximately 0.7% of live births worldwide. Although, 85%-90% of infected children are asymptomatic at birth, 10%-15% will develop late onset hearing impairment (1). Read More

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http://dx.doi.org/10.1111/apa.14814DOI Listing
April 2019
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Impact of cytomegalovirus load on host response to sepsis.

Med Microbiol Immunol 2019 Apr 11. Epub 2019 Apr 11.

Beth Israel Deaconess Medical Center, Harvard Medical School, 110 Francis St, Lowry 2G, Boston, MA, 02215, USA.

There is a decades old association between cytomegalovirus reactivation and sepsis in immune-competent hosts. Much has been learned about this relationship, which has been described as bidirectional, meaning that the virus incites and is incited by the host's inflammatory response. More recent work has suggested that chronic viral infection leaves the host with exaggerated immunity to bacterial infections. Read More

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http://dx.doi.org/10.1007/s00430-019-00603-yDOI Listing
April 2019
1 Read
3.038 Impact Factor

Eyelid ulceration from cytomegalovirus, an unusual AIDS-defining illness.

Can J Ophthalmol 2019 Apr 24;54(2):e84-e87. Epub 2018 Aug 24.

Department of Ophthalmology, University of Florida Gainesville, Fla.

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http://dx.doi.org/10.1016/j.jcjo.2018.06.006DOI Listing

Cytomegalovirus Retinitis in Children and Adolescents with Acute Leukemia following allogeneic Hematopoietic Stem Cell Transplantation.

Transpl Infect Dis 2019 Apr 10:e13089. Epub 2019 Apr 10.

Department of Pediatric Hematology and Oncology, University Children's Hospital Muenster.

Cytomegalovirus retinitis (CMVR) may occur after allogeneic hematopoietic stem cell transplantation (HSCT). However, little is known about its incidence, strategies for ophthalmic surveillance, and timely implementation of adequate antiviral treatment in pediatric allogeneic HSCT recipients. We provide a retrospective analysis of the epidemiology and clinical features of CMVR in pediatric allogeneic HSCT patients transplanted at our center over a 16-year period. Read More

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http://dx.doi.org/10.1111/tid.13089DOI Listing
April 2019
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Aortic Conduit Aneurysm and Enteric Fistula Formation in a Post Liver Transplant Patient: A potential causative role for CMV?

Transpl Infect Dis 2019 Apr 11:e13092. Epub 2019 Apr 11.

Liver Unit, University Hospitals Birmingham NHS Foundation Trust, Mindelsohn Way, Edgbaston, Birmingham, B15 2GW.

Hepatic arterial aortic conduits can be used as an alternative means of revascularising the donor liver when the native recipient hepatic artery (HA) cannot be used. Cytomegalovirus (CMV) is a common Herpesviridae infection in patients who have undergone solid organ transplants. It can be asymptomatic but may cause fever and invasive disease affecting any organ system. Read More

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http://dx.doi.org/10.1111/tid.13092DOI Listing
April 2019
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Cytomegalovirus memory inflation and immune protection.

Authors:
Luka Cicin-Sain

Med Microbiol Immunol 2019 Apr 10. Epub 2019 Apr 10.

Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany.

Cytomegalovirus (CMV) infection induces powerful and sustained T-cell responses against a few selected immunodominant antigenic epitopes. This immune response was named memory inflation, because it does not contract in the long term, and may even expand over months and years of virus latency. It is by now understood that memory inflation does not occur at the expense of the naïve T-cell pool, but rather as a competitive selection process within the effector pool, where viral antigens with higher avidity of TCR binding and with earlier expression patterns outcompete those that are expressed later and bind TCRs less efficiently. Read More

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http://dx.doi.org/10.1007/s00430-019-00607-8DOI Listing