53,338 results match your criteria Cytomegalovirus

Malignant mixed tumour of the parotid gland in a preterm neonate with cytomegalovirus infection.

BMJ Case Rep 2022 May 13;15(5). Epub 2022 May 13.

General, Visceral and Proctological Surgery, Diakonmed Diakoniekrankenhaus Chemnitzer Land gGmbH, Hartmannsdorf, Saxony, Germany

A young pregnant woman presented to the emergency department with acute lower abdominal pain. The ultrasound examination showed not only a viable fetus with a gestational age of 24 weeks but also a heteroechoic mass of about 7×7 cm involving parts of the face. The patient was found to be in active labour with rapid progression, and she gave birth to a dead female neonate. Read More

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Increased Complement-Associated Inflammation in Cytomegalovirus-Positive Hypertensive Anterior Uveitis Patients Based on the Aqueous Humor Proteomics Analysis.

J Clin Med 2022 Apr 22;11(9). Epub 2022 Apr 22.

Department of Ophthalmology, Duke University School of Medicine, Durham, NC 27710, USA.

Herpetic anterior uveitis-associated ocular inflammation is commonly manifested with ocular hypertension and glaucoma. Relative to other viruses, cytomegalovirus (CMV) positive hypertensive anterior uveitis is associated with high recurrences of uveitis, as well as with uncontrolled intraocular pressure (IOP) and a subsequent higher requirement for future glaucoma surgery. To gain novel insights into the pathogenesis of ocular hypertension in these patients, we investigated the proteome changes of the aqueous humor (AH) derived from the CMV hypertensive anterior uveitis (CMV-HAU; = 10) patients and non-glaucoma (cataract; = 10) patients using liquid chromatography with tandem mass spectrometry. Read More

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Mast Cells Meet Cytomegalovirus: A New Example of Protective Mast Cell Involvement in an Infectious Disease.

Cells 2022 Apr 21;11(9). Epub 2022 Apr 21.

Institute for Virology, Research Center for Immunotherapy (FZI), University Medical Center of the Johannes Gutenberg, University Mainz, 55131 Mainz, Germany.

Cytomegaloviruses (CMVs) belong to the β-subfamily of herpesviruses. Their host-to-host transmission involves the airways. As primary infection of an immunocompetent host causes only mild feverish symptoms, human CMV (hCMV) is usually not considered in routine differential diagnostics of common airway infections. Read More

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Direct Injection of Recombinant AAV-Containing Solution into the Oviductal Lumen of Pregnant Mice Caused In Situ Infection of Both Preimplantation Embryos and Oviductal Epithelium.

Int J Mol Sci 2022 Apr 28;23(9). Epub 2022 Apr 28.

Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.

Adeno-associated virus (AAV) vector is an efficient viral-based gene delivery tool used with many types of cells and tissues, including neuronal cells and muscles. AAV serotype 6 (AAV-6), one of numerous AAV serotypes, was recently found to efficiently transduce mouse preimplantation embryos. Furthermore, through coupling with a clustered, regularly interspaced, short palindromic repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system-a modern genome editing technology-AAV-6 has been shown to effectively create a mutation at a target locus, which relies on isolation of zygotes, in vitro viral infection, and transplantation of the infected embryos to recipient females. Read More

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Current Understanding in the Clinical Characteristics and Molecular Mechanisms in Different Subtypes of Biliary Atresia.

Int J Mol Sci 2022 Apr 27;23(9). Epub 2022 Apr 27.

Division of Paediatric Surgery, Department of Surgery, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China.

Biliary atresia is a severe obliterative cholangiopathy in early infancy that is by far the most common cause of surgical jaundice and the most common indicator for liver transplantation in children. With the advanced knowledge gained from different clinical trials and the development of research models, a more precise clinical classification of BA (i.e. Read More

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Sequencing of the Viral UL111a Gene Directly from Clinical Specimens Reveals Variants of HCMV-Encoded IL-10 That Are Associated with Altered Immune Responses to HCMV.

Int J Mol Sci 2022 Apr 22;23(9). Epub 2022 Apr 22.

Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley 6102, Australia.

Human cytomegalovirus (HCMV) is a beta-herpesvirus carried by ~80% of adults worldwide. Acute infections are often asymptomatic in healthy individuals but generate diverse syndromes in neonates, renal transplant recipients (RTR), and people with HIV (PWH). The HCMV gene UL111a encodes a homolog of human interleukin-10 (IL-10) that interacts with the human IL-10 receptor. Read More

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Combining CD34+ stem cell selection with prophylactic pathogen and leukemia directed T-cell immunotherapy to simultaneously reduce graft versus host disease, infection and leukemia recurrence after allogeneic stem cell transplant.

Am J Hematol 2022 May 12. Epub 2022 May 12.

Blood Transplant and Cell Therapies Program, Westmead Hospital, Sydney.

Background: We designed a trial to simultaneously address the problems of graft versus host disease (GVHD), infection and recurrence of malignancy after allogeneic stem cell transplantation.

Methods: CD34 stem cell isolation was used to minimise the development of acute and chronic GVHD. Two prophylactic infusions, one combining donor-derived cytomegalovirus, Epstein Barr virus and Aspergillus fumigatus specific T-cells and the other comprising donor-derived CD19 directed chimeric antigen receptor (CAR) bearing T-cells, were given 21-28 days after transplant. Read More

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Cytomegalovirus viral interleukin-10 (cmvIL-10) in patients with Aspergillus infection and effects on clinical outcome.

Mycoses 2022 May 12. Epub 2022 May 12.

Division of Clinical Skills Training, Department of Medical Education, Taipei Veterans General Hospital, Taipei.

Background: Human cytomegalovirus (CMV) is associated with aspergillosis, but the simultaneous presence of cytomegalovirus viral interleukin-10 (cmvIL-10) and aspergillosis has never been investigated. CmvIL-10 is produced by CMV-infected cells and acts as an immune modulator during CMV infection. The aim of this study was to evaluate cmvIL-10 levels in peripheral blood and its influence on the clinical outcomes of Aspergillus infection. Read More

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Mathematical Modeling of Protracted HCMV Replication using Genome Substrates and Protein Temporal Profiles.

FASEB J 2022 May;36 Suppl 1

Microbiology and Immunology, Medical College of Wisconsin, Wauwatosa, WI.

Rationale: Clinical manifestations of human cytomegalovirus (HCMV) infection, a major cause of morbidity and mortality in the immunocompromised, are associated with the lytic replication cycle. Lytic replication occurs over 96 hrs and is marked by viral DNA (vDNA) synthesis and expression of viral proteins, the latter of which can be generalized into distinct temporal classifications. Given the complexity of the lytic replication cycle, mathematical modeling can be used to probe this elaborate system. Read More

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Human Cytomegalovirus (HCMV) Tegument Protein pUL35 in the establishment of latency in models of quiescent infection.

FASEB J 2022 May;36 Suppl 1

Biology, Fort Lewis College, Durango, CO.

Human Cytomegalovirus (HCMV) is a double stranded DNA, beta herpes virus that primarily infects those with transplants, advanced HIV/AIDS, cancer, newborns, and those with a compromised immune system. This virus is the leading cause of virus-induced birth defects and can lead to death. HCMV is able to establish a latent phase of virus replication, in which the host is not producing infectious virus, but still retains the complete genome. Read More

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Enhanced Metabolism and Altered Paracrine Signaling in Glioblastoma Following Cytomegalovirus Infection.

FASEB J 2022 May;36 Suppl 1

Microbiology and Immunology, Tulane University, New Orleans, LA.

Glioblastoma (GBM) is an aggressive central nervous system neoplasia with an extremely poor prognosis. Despite intense research, 5-year survival rates have not increased for the past 20 years, pointing to the need for alternative therapeutic strategies. Accumulating evidence has described a role for cytomegalovirus (CMV) in GBM, yet the mechanism of action is still unclear. Read More

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UL25 Deletion in hCMV and Impacts on Viral Replication Cycles.

Asa K Laskie

FASEB J 2022 May;36 Suppl 1

Biology, Fort Lewis College, Durango, CO.

Human Cytomegalovirus (hCMV) is a beta herpes virus that impacts a significant portion of the adult U.S. population (50-94% seroprevalence, depending on the region). Read More

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Predictors of cochleovestibular dysfunction in children with congenital cytomegalovirus infection.

Eur J Pediatr 2022 May 13. Epub 2022 May 13.

Department of Otolaryngology, Robert Debre Hospital, Assistance Publique Hôpitaux de Paris (APHP), Paris University, 48 boulevard Sérurier, 75019, Paris, France.

The purpose of this study is to assess the predictive factors of both hearing and vestibular impairment in congenitally cytomegalovirus-infected children (cCMV) through a multivariate analysis of clinical and imaging characteristics collected during pregnancy and at birth. This retrospective study was conducted between March 2014 and March 2020, including confirmed congenitally CMV-infected children with a complete vestibular and hearing assessment. Data concerning pregnancy, date of infection, clinical characteristics, and symptomatology at birth were collected. Read More

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CMV infection combined with Acute GVHD associated with poor CD8+ T-cell immune reconstitution and poor prognosis post HLA-matched allo-HSCT.

Clin Exp Immunol 2022 May 12. Epub 2022 May 12.

Peking University People's Hospital, Peking University Institute of Hematology, National Clinical Research Center for Hematologic Disease, Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, Beijing, China.

Cytomegalovirus (CMV) infection and acute graft-versus-host disease (aGVHD) are two major complications that contribute to a poor prognosis after hematopoietic stem cell transplantation (HSCT). Superior early immune reconstitution (IR) is associated with improved survival after HSCT. However, when all three factors, CMV infection, aGVHD, and IR, are concomitantly considered, the effects of the triple events on HSCT are still unknown and should be studied further. Read More

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Immunoprofiling reveals cell subsets associated with the trajectory of cytomegalovirus reactivation post stem cell transplantation.

Nat Commun 2022 May 11;13(1):2603. Epub 2022 May 11.

School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.

Human cytomegalovirus reactivation is a major opportunistic infection after allogeneic haematopoietic stem cell transplantation and has a complex relationship with post-transplant immune reconstitution. Here, we use mass cytometry to define patterns of innate and adaptive immune cell reconstitution at key phases of human cytomegalovirus reactivation in the first 100 days post haematopoietic stem cell transplantation. Human cytomegalovirus reactivation is associated with the development of activated, memory T-cell profiles, with faster effector-memory CD4 T-cell recovery in patients with low-level versus high-level human cytomegalovirus DNAemia. Read More

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CMV specific T cell immune response in hepatitis C negative kidney transplant recipients receiving transplant from hepatitis C viremic donors and hepatitis C aviremic donors.

Ren Fail 2022 Dec;44(1):831-841

Department of Medicine, Division of Nephrology & Hypertension, University of Utah, Salt Lake City, UT, USA.

Kidney transplants (KT) from hepatitis C (HCV) viremic donors to HCV negative recipients has shown promising renal outcomes, however, high incidence of cytomegalovirus (CMV) viremia were reported. We performed a prospective cohort study of 52 HCV negative KT recipients from Methodist University Hospital including 41 receiving transplants from HCV aviremic donors and 11 from HCV viremic donors. CMV specific CD4+ and CD8 + T cell immunity was measured by intracellular flow cytometry assay. Read More

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December 2022

Using machine learning to predict COVID-19 infection and severity risk among 4510 aged adults: a UK Biobank cohort study.

Sci Rep 2022 May 11;12(1):7736. Epub 2022 May 11.

Infections and Cancer Epidemiology Division, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Many risk factors have emerged for novel 2019 coronavirus disease (COVID-19). It is relatively unknown how these factors collectively predict COVID-19 infection risk, as well as risk for a severe infection (i.e. Read More

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Vestibular and balance dysfunction in children with congenital CMV: a systematic review.

Arch Dis Child Fetal Neonatal Ed 2022 May 11. Epub 2022 May 11.

Academic Paediatrics, Royal Alexandra Children's Hospital, Brighton, UK.

Objective: This systematic review evaluates vestibular and balance dysfunction in children with congenital cytomegalovirus (cCMV), makes recommendations for clinical practice and informs future research priorities.

Design: MEDLINE, Embase, EMCARE, BMJ Best Practice, Cochrane Library, DynaMed Plus and UpToDate were searched from inception to 20 March 2021 and graded according to Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria.

Patients: Children with cCMV diagnosed within 3 weeks of life from either blood, saliva and/or urine (using either PCR or culture). Read More

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A TRUSTED targeted mass spectrometry assay for pan-herpesvirus protein detection.

Cell Rep 2022 May;39(6):110810

Department of Molecular Biology, Princeton University, Lewis Thomas Laboratory, Washington Road, Princeton, NJ 08544, USA. Electronic address:

The presence and abundance of viral proteins within host cells are part of the essential signatures of the cellular stages of viral infections. However, methods that can comprehensively detect and quantify these proteins are still limited, particularly for viruses with large protein coding capacity. Here, we design and experimentally validate a mass spectrometry-based Targeted herpesviRUS proTEin Detection (TRUSTED) assay for monitoring human viruses representing the three Herpesviridae subfamilies-herpes simplex virus type 1, human cytomegalovirus (HCMV), and Kaposi sarcoma-associated herpesvirus. Read More

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Bendamustine treatment of haematological malignancies: significant risks of opportunistic viral, fungal and bacterial infections.

Hematology 2022 Dec;27(1):535-542

Department of Medicine, Queen Mary Hospital, Pokfulam, Hong Kong.

Objectives: Bendamustine is a standard treatment for low-grade B-cell lymphomas, and considered safe in clinical trials. Its safety in routine practice might be different.

Methods: We retrospectively analyzed the infection complications in an unselected cohort of patients treated with bendamustine over a nine-year period. Read More

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December 2022

Utility of Cytomegalovirus Cell-Mediated Immunity Assays in Solid Organ Transplantation.

J Clin Microbiol 2022 May 11:e0171621. Epub 2022 May 11.

Transplant Infectious Diseases and Multi-Organ Transplant Program, University Health Network, Toronto, Ontario, Canada.

Cytomegalovirus (CMV) is one of the most important viral complications after solid organ transplantation (SOT). Current preventive and management strategies rely primarily on serologic and viral load testing and remain suboptimal. To address these issues, multiple techniques to measure CMV-specific cell-mediated immunity (CMI) have been developed and evaluated in clinical studies over the past two decades. Read More

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Health impact of seven herpesviruses on (pre)diabetes incidence and HbA: results from the KORA cohort.

Diabetologia 2022 May 11. Epub 2022 May 11.

Institute of Medical Information Sciences, Biometry and Epidemiology, Ludwig-Maximilians University, Munich, Germany.

Aims/hypothesis: The prevalence of type 2 diabetes is increasing worldwide, and previous studies have suggested that it is higher in individuals who are seropositive for herpesviruses. This study examines the prospective association of herpesviruses with (pre)diabetes to evaluate their potential role in diabetes aetiology.

Methods: Two follow-up examinations of the German population-based KORA cohort (F4 and FF4) were used to identify participants with normal glucose tolerance at baseline, thus being at risk for (pre)diabetes (n = 1257). Read More

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A comparative analysis depicting the disease characteristics and phylogenetic signature of human cytomegalovirus infection in Human Immunodeficiency Virus 1 seropositive patients with end-organ retinitis and gastro-enteric diseases.

Sci Rep 2022 May 10;12(1):7617. Epub 2022 May 10.

ICMR-NICED Virus Laboratory, ICMR-National Institute of Cholera and Enteric Diseases, Kolkata, GB4, ID & BG Hospital Campus, Dr. S.C Banerjee road, Beliaghata, Kolkata, West Bengal, 700010, India.

During advanced HIV infection, Human Cytomegalovirus (HCMV) has been proven to produce devitalizing end-organ diseases (EOD). The interactive co-existence of HIV and HCMV has been reported by many researchers and has been suggested to be linked with a more aggressive disease state. This study has been designed to bring forward an assessment of the clinical risk factors capable of defining the conditions of HCMV induced retinitis and gastro-enteric diseases among HIV1 seropositive patients. Read More

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Human cytomegalovirus RNA2.7 inhibits RNA polymerase II (Pol II) Serine-2 phosphorylation by reducing the interaction between Pol II and phosphorylated cyclin-dependent kinase 9 (pCDK9).

Virol Sin 2022 Feb 28. Epub 2022 Feb 28.

Virology Laboratory, Shengjing Hospital of China Medical University, Shenyang, 110004, China; Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, 110004, China; Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang, 110004, China. Electronic address:

Human cytomegalovirus (HCMV) is a ubiquitous pathogen belongs to betaherpesvirus subfamily. RNA2.7 is a highly conserved long non-coding RNA accounting for more than 20% of total viral transcripts. Read More

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February 2022

New intranasal and injectable gene therapy for healthy life extension.

Proc Natl Acad Sci U S A 2022 May 10;119(20):e2121499119. Epub 2022 May 10.

Department of Microbiology, Biochemistry, and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ 07103.

SignificanceUsing CMV as a gene therapy vector we illustrated that CMV can be used therapeutically as a monthly inhaled or intraperitoneally delivered treatment for aging-associated decline. Exogenous telomerase reverse transcriptase or follistatin genes were safely and effectively delivered in a murine model. This treatment significantly improved biomarkers associated with healthy aging, and the mouse lifespan was increased up to 41% without an increased risk of cancer. Read More

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When Push Comes to Shove! Emergency ABO-Incompatible Pediatric Living Donor Liver Transplant for Acute Wilson's Disease.

J Clin Exp Hepatol 2022 Mar-Apr;12(2):658-663. Epub 2021 Aug 21.

Department of Liver Transplant and Hepatopancreaticobiliary Surgery, Gleneagles Global Health City, Perumbakkam, Chennai, India.

ABO-incompatible living donor liver transplantation (ABOi-LDLT) is on the rise as a viable option in countries with limited access to deceased donor grafts. While reported outcomes of ABOi-LT in children are similar to ABO- Compatible liver transplant (ABOc-LT), most children beyond 1-2 years of age will need desensitization to overcome the immunological barrier of incompatible blood groups. The current standard protocol for desensitization is Rituximab that targets B lymphocytes and is given 2-3 weeks prior to LT. Read More

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Coronavirus Disease 2019-associated mucormycosis and cytomegalovirus coinfection in a kidney transplant recipient.

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1501-1504

Department of Nephrology and Renal Transplantation, Virinchi Hospitals, Hyderabad, Telangana, India.

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Comparison of short-term outcomes with and without induction therapy in low-risk renal transplant recipients.

Saudi J Kidney Dis Transpl 2021 Sep-Oct;32(5):1273-1282

Department of Nephrology, Sir Ganga Ram Hospital, New Delhi, India.

With low rates of rejection with current immunosuppression consisting of steroids, mycophenolic acid and tacrolimus, the question arises whether induction offers any additional benefit in low-risk renal transplant recipients. This study evaluated outcomes with and without induction in low-risk renal transplant recipients. A prospective observational study in which 100 low-risk renal transplant recipients were included and divided into two groups - one that received induction (IND) and another that did not (NO IND). Read More

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Ganciclovir and Valganciclovir Use Among Infants With Congenital Cytomegalovirus: Data From a Multicenter Electronic Health Record Dataset in the United States.

J Pediatric Infect Dis Soc 2022 May 9. Epub 2022 May 9.

Division of Viral Diseases, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

Among 342 US infants with congenital cytomegalovirus treated with antivirals, 114 (33%) received ganciclovir (with or without valganciclovir) and 228 (67%) received valganciclovir only, for a median of 8 and 171 days, starting at a median of 15 and 45 days of life, respectively, with neutropenia diagnosed in 25% and 17%. Read More

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