780,766 results match your criteria Cytokine & Growth Factor Reviews [Journal]


Oxytocin in the tumor microenvironment is associated with lower inflammation and longer survival in advanced epithelial ovarian cancer patients.

Psychoneuroendocrinology 2019 Apr 6;106:244-251. Epub 2019 Apr 6.

Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Miller School of Medicine, University of Miami, United States.

Background: Prior research demonstrates a protective role for oxytocin in ovarian cancer based on its anti-proliferative, anti-migratory, and anti-invasive effects in vitro and in vivo. However, the role of endogenous oxytocin has not been examined in ovarian cancer patients. Oxytocin also has anti-inflammatory properties that have not been examined in cancer. Read More

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http://dx.doi.org/10.1016/j.psyneuen.2019.04.007DOI Listing
April 2019
1 Read

Curcumin attenuates collagen-induced rat arthritis via anti-inflammatory and apoptotic effects.

Int Immunopharmacol 2019 Apr 17;72:292-300. Epub 2019 Apr 17.

Department of Immunology, Medical College of Nanchang University, Nanchang 330000, China. Electronic address:

Curcumin is a natural herbal product that has been popularly used to treat autoimmune diseases in China; however, its effects on rheumatoid arthritis and its mechanism are not clear. The main purposes of this study are to explore the therapeutic effects of curcumin on collagen-induced arthritis (CIA) rats and the pharmacological mechanism. In the present study, CIA rats were established by injecting bovine type II collagen. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15675769193079
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http://dx.doi.org/10.1016/j.intimp.2019.04.027DOI Listing
April 2019
1 Read

Preliminary studies on the anti-osteoporosis activity of Baohuoside I.

Biomed Pharmacother 2019 Apr 17;115:108850. Epub 2019 Apr 17.

Department of Spine Surgery, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, China. Electronic address:

The aim of the present study was to investigate the anti-osteoporotic activity of Baohuoside I, an active component of Herba Epimedii. Effects of Baohuoside I on the differentiation of BMSCs and the formation of adipocytes were evaluated using alkaline phosphatase staining and methylene blue staining method, respectively. Osteoporosis model was established in ovariectomized rats prior to the measurement of the serum SOD and MDA levels as well as the expression of inflammatory cytokines protein in the rats' tissues after treatment with Baohuoside I using ELISA assay kits. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07533322183753
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http://dx.doi.org/10.1016/j.biopha.2019.108850DOI Listing
April 2019
1 Read

APOC3 promotes TNF-α-induced expression of JAM-1 in endothelial cell via PI3K-IKK2-p65 pathway.

Cardiovasc Pathol 2019 Mar 4;41:11-17. Epub 2019 Mar 4.

Department of Laboratory Medicine, Affiliated Hospital of Nantong University, 20 Xi Si Road, Nantong 226001, People's Republic of China; Insitute of Public Health, Nantong University, 9 Se Yuan Road, Nantong 226001, People's Republic of China. Electronic address:

Atherosclerosis is a chronic inflammatory disease with lipid accumulation. Apolipoprotein C3 (APOC3), which is an important regulator of human lipid metabolism, is associated with multiple vascular mechanisms in atherosclerosis and proinflammatory responses. We have previously reported that the expression of inflammatory cytokine TNF-α is elevated in human endothelial cells (HUVECs) after APOC3 treatment. Read More

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http://dx.doi.org/10.1016/j.carpath.2019.02.005DOI Listing

Modificated Mahuang-Tang, a traditional herbal medicine suppresses inflammatory responses induced by cigarette smoke in human airway epithelial cell and mice.

Phytomedicine 2018 Dec 1;59:152777. Epub 2018 Dec 1.

College of Veterinary Medicine (BK21 Plus Project Team), Chonnam National University, 77 Yongbong-ro, Buk-gu, Gwangju 500-757, Republic of Korea. Electronic address:

Background: Cigarette smoke (CS) is a major contributor to the high incidence of chronic obstructive pulmonary disease (COPD) featured as chronic inflammation and airway obstruction. Mahuang-Tang is a traditional polyherbal mixture composed of four different herbs. It is widely used in Asia as a remedy for allergic reaction and inflammation. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.037DOI Listing
December 2018

Inhibition of 3β-Hydroxysteroid Dehydrogenase Type 1 Suppresses Interleukin-6 in Breast Cancer.

J Surg Res 2019 Apr 17;241:8-14. Epub 2019 Apr 17.

Department of Surgery, MacKay Memorial Hospital and Mackay Medical College, Taipei, Taiwan; Department of Medical Research, MacKay Memorial Hospital, Taipei, Taiwan; Mackay Junior College of Medicine, Nursing, and Management, Taipei, Taiwan. Electronic address:

Background: Recently, we demonstrated that the expression of 3β-hydroxysteroid dehydrogenase type 1 (HSD3B1) in breast cancer is associated with shorter recurrence-free survival, and genetic or pharmacologic inhibition of HSD3B1 reduced colony formation and xenograft growth. However, the mechanisms are unclear.

Methods: Triple-negative MDA-MB-231 and BT-20 breast cancer cells underwent HSD3B1 silencing. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.024DOI Listing

Phosphodiesterase-4 Inhibitor Roflumilast Attenuates Pulmonary Air Emboli-Induced Lung Injury.

J Surg Res 2019 Apr 17;241:24-30. Epub 2019 Apr 17.

Division of Pulmonary Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu-Chi University, Hualien, Taiwan. Electronic address:

Background: Pulmonary air embolism (PAE)-induced acute lung injury (ALI) can be caused by massive air entry into the lung circulation. PAE can occur during diving, aviation, and some iatrogenic invasive procedures. PAE-induced ALI presents with severe inflammation, hypoxia, and pulmonary hypertension, and it is a serious complication resulting in significant morbidity and mortality. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00224804193014
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http://dx.doi.org/10.1016/j.jss.2019.03.028DOI Listing
April 2019
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Triple co-culture of human alveolar epithelium, endothelium and macrophages for studying the interaction of nanocarriers with the air-blood barrier.

Acta Biomater 2019 Apr 17. Epub 2019 Apr 17.

HIPS - Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research (HZI), Saarland University, Universitätscampus E8.1, 66123 Saarbrücken, Germany; Department of Pharmacy, Saarland University, 66123, Saarbrücken, Germany. Electronic address:

Predictive in vitro models are valuable alternatives to animal experiments for evaluating the transport of molecules and (nano)particles across biological barriers. In this work, an improved triple co-culture of air-blood barrier was set-up, being exclusively constituted by human cell lines that allowed to perform experiments at air-liquid interface. Epithelial NCI-H441 cells and endothelial HPMEC-ST1. Read More

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http://dx.doi.org/10.1016/j.actbio.2019.04.037DOI Listing

Nanoemulsion strategy of pioglitazone for the treatment of skin inflammatory diseases.

Nanomedicine 2019 Apr 17. Epub 2019 Apr 17.

Institute of Nanoscience and Nanotechnology (IN2UB), University of Barcelona, 08028 Barcelona, Spain; Department of Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy, University of Granada, Granada, Spain. Electronic address:

Pioglitazone (PGZ) is a peroxisome proliferator-activated receptor agonist. Its role in the inflammatory response modulation opens the door for additional therapeutic applications. The purpose of this study was to develop a pioglitazone nanoemulsion (PGZ-NE) to investigate its anti-inflammatory efficacy on the skin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S15499634193007
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http://dx.doi.org/10.1016/j.nano.2019.03.017DOI Listing
April 2019
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Cytokine production in allergic and Trichuris trichiura-infected children from an urban region of the Brazilian northeast.

Parasitol Int 2019 Apr 17. Epub 2019 Apr 17.

Immunology Section, Keizo Asami Immunopathology Laboratory (LIKA), Federal University of Pernambuco, Recife, Brazil; Department of Pharmaceutical Sciences, Health Sciences Center, Federal University of Pernambuco, Recife, Brazil. Electronic address:

The relationship between the cellular immune response during Trichuris trichiura infection and asthma has not yet been established. In this study, the cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, TNF-α, IFN-γ and IL-17A were evaluated in asthmatic children harboring T. trichiura. Read More

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http://dx.doi.org/10.1016/j.parint.2019.04.015DOI Listing

Regulation of human inducible nitric oxide synthase expression by an upstream open reading frame.

Nitric Oxide 2019 Apr 17. Epub 2019 Apr 17.

Department of Pharmacology, University Medical Center of the Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 67, 55101, Mainz, Germany. Electronic address:

The human inducible nitric oxide synthase (iNOS) gene contains an upstream open reading frame (uORF) in its 5'-untranslated region (5'-UTR) implying a translational regulation of iNOS expression. Transfection experiments in human DLD-1 cells revealed that the uORF although translatable seems not to inhibit the translation start at the bona fide ATG. Our data clearly show that human iNOS translation is cap-dependent and that the 5'-UTR of the iNOS mRNA contains no internal ribosome entry site. Read More

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http://dx.doi.org/10.1016/j.niox.2019.04.008DOI Listing

Human Erythroblasts with c-Kit Activating Mutations Have Reduced Cell Culture Costs and Remain Capable of Terminal Maturation.

Exp Hematol 2019 Apr 17. Epub 2019 Apr 17.

Center for Pediatric Biomedical Research, Department of Pediatrics, University of Rochester, Rochester, NY. Electronic address:

A major barrier to the in vitro production of red blood cells for transfusion therapy is the cost of culture components, with cytokines making up greater than half of the culture costs. Cell culture cytokines also represent a major expense for in vitro studies of human erythropoiesis. HUDEP2 cells are an E6/E7 immortalized erythroblast line used for the in vitro study of human erythropoiesis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S0301472X193013
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http://dx.doi.org/10.1016/j.exphem.2019.04.001DOI Listing
April 2019
4 Reads

Ameliorative effect of Atractylodes macrocephala essential oil combined with Panax ginseng total saponins on 5-fluorouracil induced diarrhea is associated with gut microbial modulation.

J Ethnopharmacol 2019 Apr 17:111887. Epub 2019 Apr 17.

College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. Electronic address:

Ethnopharmacological Relevance: Traditional Chinese medicine (TCM) holds that deficiency of spleen-Qi is the major pathogenesis of chemotherapy-induced diarrhea (CID). Herb pair of Atractylodes macrocephala Koidz. (AM) and Panax ginseng C. Read More

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http://dx.doi.org/10.1016/j.jep.2019.111887DOI Listing
April 2019
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A novel polysaccharide from Dendrobium devonianum serves as a TLR4 agonist for activating macrophages.

Int J Biol Macromol 2019 Apr 17. Epub 2019 Apr 17.

School of Basic Medical Sciences & Forensic Medicine, Hangzhou Medical College, Hangzhou 310053, China. Electronic address:

Dendrobium devonianum has been used as herbal medicines and nutraceutical products since ancient time in China. However, its chemical composition and pharmacological mechanisms are not fully known. In present studies, by chemical purification and characteristic identification, we discovered a novel polysaccharide from D. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01418130183710
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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.125DOI Listing
April 2019
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The flavonoid chrysin protects against zearalenone induced reproductive toxicity in male mice.

Toxicon 2019 Apr 17. Epub 2019 Apr 17.

Laboratório de Avaliações Farmacológicas e Toxicológicas Aplicadas às Moléculas Bioativas (Laftambio Pampa), Universidade Federal Do Pampa, Campus Itaqui, 97650-000, Itaqui, RS, Brazil.

The mycotoxin zearalenone (ZEA) has strong estrogenic effects and elicits reproductive toxicity. Chrysin is a natural flavonoid found in many plant and has a broad range of pharmacological activities, including anticancer, antioxidant and anti-inflammatory. The present study aimed to investigate the potential protective effects of chrysin against ZEA toxicity. Read More

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http://dx.doi.org/10.1016/j.toxicon.2019.04.004DOI Listing

Pro-apoptotic and anti-inflammatory effects of araloside A on human rheumatoid arthritis fibroblast-like synoviocytes.

Chem Biol Interact 2019 Apr 17. Epub 2019 Apr 17.

Department of Rheumatology and Immunology, Huaihe Hospital of Henan University, Kaifeng, 475000, Henan, China. Electronic address:

Rheumatoid arthritis fibroblast-like synoviocytes play an essential role in the occurrence and progression of rheumatoid arthritis. As the main pharmacologically active components of Aralia taibaiensis, total saponins, particularly triterpenoid saponins, have been shown to possess multiple pharmacological activities including relieving rheumatism. However, the effect of araloside A, a triterpenoid saponin extracted from the root bark of Aralia taibaiensis, on rheumatoid arthritis remains unknown. Read More

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http://dx.doi.org/10.1016/j.cbi.2019.04.025DOI Listing

The contribution of KSHV to mortality in hospitalized HIV-infected patients being investigated for tuberculosis in South Africa.

J Infect Dis 2019 Apr 20. Epub 2019 Apr 20.

Division of Medical Biochemistry and Structural Biology, Department of Integrative Biomedical Sciences, University of Cape Town, South Africa.

Background: Despite increasing numbers of human immunodeficiency virus (HIV)-infected South Africans receiving antiretroviral therapy (ART), tuberculosis remains the leading cause of mortality. Approximately 25% of patients treated for tuberculosis have microbiologically unconfirmed diagnoses. We assessed whether elevated Kaposi's sarcoma-associated Herpes Virus (KSHV) viral load (VL) contributes to mortality in hospitalized HIV-infected patients investigated for tuberculosis. Read More

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https://academic.oup.com/jid/advance-article/doi/10.1093/inf
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http://dx.doi.org/10.1093/infdis/jiz180DOI Listing
April 2019
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Revisiting Tramadol: A Multi-Modal Agent for Pain Management.

Authors:
Ahmed Barakat

CNS Drugs 2019 Apr 19. Epub 2019 Apr 19.

Department of Medical Pharmacology, Faculty of Medicine, Assiut University, Assiut, 71515, Egypt.

Tramadol-an atypical opioid analgesic-has a unique pharmacokinetic and pharmacodynamic profile, with opioidergic, noradrenergic, and serotonergic actions. Tramadol has long been used as a well-tolerated alternative to other drugs in moderate pain because of its opioidergic and monoaminergic activities. However, cumulative evidence has been gathered over the last few years that supports other likely mechanisms and uses of tramadol in pain management. Read More

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http://link.springer.com/10.1007/s40263-019-00623-5
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http://dx.doi.org/10.1007/s40263-019-00623-5DOI Listing
April 2019
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Possible Molecular Mediators Involved and Mechanistic Insight into Fibromyalgia and Associated Co-morbidities.

Neurochem Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India.

Fibromyalgia is a chronic complex syndrome of non-articulate origin characterized by musculoskeletal pain, painful tender points, sleep problems and co-morbidities including depression, migraine. The etiopathogenesis of fibromyalgia is complex, variable and remains inconclusive. The etiological factors that have been defined include stress, genetic predisposition and environmental components. Read More

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http://link.springer.com/10.1007/s11064-019-02805-5
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http://dx.doi.org/10.1007/s11064-019-02805-5DOI Listing
April 2019
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Systematic assessment of the clinicopathological prognostic significance of tissue cytokine expression for lung adenocarcinoma based on integrative analysis of TCGA data.

Sci Rep 2019 Apr 19;9(1):6301. Epub 2019 Apr 19.

Department of Medical Oncology, Chinese People's Liberation Army General Hospital, Beijing, 100853, China.

Dysregulated intratumoral immune reactions are shaped by complex networks of cytokines, which coordinate with tumor cells to determine tumor progression and aggressiveness. In lung adenocarcinoma (LUAD), the role of intratumoral cytokine gene expression for stratifying prognosis has not been systematically investigated. Using high-dimensional datasets of cancer specimens from clinical patients in The Cancer Genome Atlas (TCGA), we explored the transcript abundance and prognostic impact of 27 clinically evaluable cytokines in 500 LUAD tumor samples according to clinicopathological features and two common driver mutations (EGFR and KRAS). Read More

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http://dx.doi.org/10.1038/s41598-019-42345-0DOI Listing

Inflammatory cytokines and ischemic stroke risk: The REGARDS cohort.

Neurology 2019 Apr 19. Epub 2019 Apr 19.

From the Departments of Pathology and Laboratory Medicine (N.S.J., N.A.Z., M.C.) and Medicine (N.A.Z., M.C.), University of Vermont Larner College of Medicine, Burlington; Department of Biometry (P.W.C.), University of Vermont, Burlington; Department of Biostatistics (S.E.J.), University of Alabama at Birmingham; Department of Epidemiology and Biostatistics (L.A.M.), Dornsife School of Public Health, Drexel University, Philadelphia, PA; and Department of Neurology and Rehabilitation Medicine (B.K.), University of Cincinnati College of Medicine, OH.

Objective: We studied circulating interleukin (IL)-6, IL-8, and IL-10 concentrations and incident ischemic stroke risk in a biracial cohort, and determined if these cytokines mediated the racial disparity in stroke incidence affecting the black population.

Methods: The Reasons for Geographic and Racial Differences in Stroke study enrolled 30,237 black and white men and women age ≥45 in 2003-2007. We measured baseline IL-6, IL-8, and IL-10 in a case-cohort study of 557 participants with incident stroke over 5. Read More

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http://dx.doi.org/10.1212/WNL.0000000000007416DOI Listing

Rapid generation of multivirus-specific T lymphocytes for the prevention and treatment of respiratory viral infections.

Haematologica 2019 Apr 19. Epub 2019 Apr 19.

Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, TX, USA

Respiratory tract infections due to community-acquired respiratory viruses including respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus are detected in up to 40% of allogeneic hematopoietic stem cell transplant recipients in whom they cause severe symptoms including pneumonia and bronchiolitis and can be fatal. Given the lack of effective antivirals and the data from our group demonstrating that adoptively transferred ex vivo-expanded virus-specific T cells can be clinically beneficial for the treatment of both latent (Epstein-Barr virus, cytomegalovirus, BK virus, human herpesvirus 6) and lytic (adenovirus) viruses, we investigated the potential for extending this immunotherapeutic approach to respiratory viruses. We now describe a system that rapidly generates a single preparation of polyclonal (CD4+ and CD8+) virus-specific T cells reactive against 12 antigens derived from 4 viruses (respiratory syncytial virus, Influenza, parainfluenza virus 3 and human metapneumovirus) that commonly cause post-transplant morbidity and mortality. Read More

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http://dx.doi.org/10.3324/haematol.2018.206896DOI Listing

Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection.

Cell Host Microbe 2019 Apr 13. Epub 2019 Apr 13.

Department of Microbiology, Immunology and Cancer Biology, University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA; Department of Pathology, University of Virginia Health System, Charlottesville, VA 22908, USA. Electronic address:

Clostridium difficile infection (CDI) is the number one hospital-acquired infection in the United States. CDI is more common and severe in inflammatory bowel disease patients. Here, we studied the mechanism by which prior colitis exacerbates CDI. Read More

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http://dx.doi.org/10.1016/j.chom.2019.03.003DOI Listing

Biological and Clinical Significance of Human NKRP1A/LLT1 Receptor/Ligand Interactions.

Crit Rev Immunol 2018 ;38(6):479-489

Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland.

Killer cell lectin-like receptors (KLRs) are C-type lectin-like glycoproteins encoded by genes clustered in the natural killer gene complex (NKC) located on the short arm of human chromosome 12. In addition to the NKG2 subfamily, the NKC includes a less characterized group of genes coding for NKRP1 receptors and their ligands of the C-type lectin (CLEC) subfamily. Among this group, the best recognized is the NKRP1A/LLT1 pair encoded respectively by the KLRB1 and CLEC2D genes. Read More

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http://www.dl.begellhouse.com/journals/2ff21abf44b19838,50bd
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http://dx.doi.org/10.1615/CritRevImmunol.2019029559DOI Listing
January 2018
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IL-33 in Tumor Immunity: Nothing to Sneeze At.

Crit Rev Immunol 2018 ;38(6):453-470

Robert H. Lurie Comprehensive Cancer Center, Department of Medicine-Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, Illinois; Biotherapy Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Although immunotherapy has been at the forefront of cancer therapy for the last several years, better clinical responses are still desired. Interleukin-33 is perhaps one of the most overlooked antitumor cytokines. Its ability to promote type 1 immune responses, which control tumor growth in preclinical animal models is overshadowed by its association with type 2 immunity and poor prognosis in some human cancers. Read More

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http://dx.doi.org/10.1615/CritRevImmunol.2018026335DOI Listing
January 2018
1 Read

Placental programming of neuropsychiatric disease.

Pediatr Res 2019 Apr 19. Epub 2019 Apr 19.

Department of Pediatrics, Division of Neonatology, Children's Research Institute at Children's National Medical Center, Washington, DC, USA.

The placenta is vital for fetal growth, and compromised function is associated with abnormal development, especially of the brain. Linking placental function to brain development is a new field we have dubbed neuroplacentology. Approximately 380,000 infants in the United States each year abruptly lose placental support upon premature birth, and more than 10% of pregnancies are affected by more insidious placental dysfunction such as preeclampsia or infection. Read More

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http://dx.doi.org/10.1038/s41390-019-0405-9DOI Listing

Development of a C1q-immobilized (Cim) assay to measure total antibodies to infliximab and its clinical relevance in patients with inflammatory bowel disease.

Cytokine 2019 Apr 16;120:54-61. Epub 2019 Apr 16.

IBD Centre, Toho University Sakura Medical Centre, Chiba, Japan. Electronic address:

Objective: Determination of antibodies to infliximab (ATI) is desirable for the management of patients with inflammatory bowel disease (IBD) who receive infliximab. Conventional ligand-binding ATI-assays detect only free-form of ATI, potentially increasing the proportion of patients with undetectable ATI, but with adequate trough infliximab (TRI) level who experience loss of response (LOR) to infliximab. We investigated this assertion using a novel ATI-Cim assay. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.014DOI Listing

MicroRNA-181b-5p attenuates early postoperative cognitive dysfunction by suppressing hippocampal neuroinflammation in mice.

Cytokine 2019 Apr 16;120:41-53. Epub 2019 Apr 16.

Department of Anesthesiology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei, China. Electronic address:

Background: Postoperative cognitive dysfunction (POCD) is a common complication after surgery and its occurrence is associated with increased morbidity and mortality. However, the pathophysiology of this complication remains largely unknown. Efforts to identify causes of POCD have focused on the hippocampal neuroinflammation. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.005DOI Listing

Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.

Cytokine 2019 Apr 16;120:28-40. Epub 2019 Apr 16.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. Electronic address:

Viperin is an interferon-inducible protein that helps in protecting mammals against various virus infections. Viperin is a highly conserved member of the interferon-stimulated genes (ISG) family in many species. Viperin has been shown to play a pivotal role in the innate immunity of chicken; however, its role has not been explored in its antiviral potential. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.007DOI Listing

Interleukin-18 serum levels in sepsis: Correlation with disease severity and inflammatory markers.

Cytokine 2019 Apr 16;120:22-27. Epub 2019 Apr 16.

Department of Anesthesiology and Intensive TherapyCare, 4th Military Hospital of Wroclaw, Weigla 5, 50-981 Wroclaw, Poland; Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland. Electronic address:

Purpose: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection and a syndrome shaped by pathogen and host factors with characteristic that evolve over time. The study was conducted to evaluate the prognostic and discriminative value of IL-18 assessment in comparison to PCT, CRP, WBC in early stage of sepsis and septic shock.

Methods: An observational and prospective study was conducted in the group of 40 ICU patients with diagnosis of sepsis or septic shock, serum PCT, IL-18, CRP and WBC measurements were performed on admission, and on the 2nd, 3rd and 5th therapy day. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.003DOI Listing

Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia.

Cytokine 2019 Apr 16;119:202-213. Epub 2019 Apr 16.

Institute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, Krakow, Poland. Electronic address:

The complex neuroimmunological interactions mediated by chemokines are suggested to be responsible for the development of neuropathic pain. The lack of knowledge regarding the detailed pathomechanism of neuropathy is one reason for the lack of optimally efficient therapies. Recently, several lines of evidence indicated that expression of CCR2 is increased in spinal cord neurons and microglial cells after peripheral nerve injury. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.007DOI Listing

Borrelia burgdorferi basic membrane protein A initiates proinflammatory chemokine storm in THP 1-derived macrophages via the receptors TLR1 and TLR2.

Biomed Pharmacother 2019 Apr 16;115:108874. Epub 2019 Apr 16.

Department of Biochemistry and Molecular Biology, Kunming Medical University, Kunming 650500, China.

Lyme disease, reffered to as Lyme borreliosis, is a tick-borne zoonotic disease caused by Borrelia burgdorferi spirochetes. Lyme arthritis, the most common, serious and harmful manifestation during the late stages of Lyme disease, is closely associated with the Borrelia burgdorferi basic membrane protein A (BmpA). Chemokines are also reported to have an important role in Lyme arthritis. Read More

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http://dx.doi.org/10.1016/j.biopha.2019.108874DOI Listing
April 2019
2 Reads

Modulation of the somatotropic axis, adiponectin and cytokine secretion during highly pathogenic porcine reproductive and respiratory syndrome virus type 1 (HP-PRRSV-1) infection.

Res Vet Sci 2019 Apr 11;124:263-269. Epub 2019 Apr 11.

Department of Veterinary Science, University of Parma, Strada del Taglio, 10, 43126 Parma, Italy.

Porcine reproductive and respiratory syndrome virus (PRRSV) is known to be clinically responsible for reproductive failure in sows and post-weaning respiratory disease in growing piglets. During the last years, highly pathogenic PRRSV isolates have been discovered. In Italy, a PRRSV-1 subtype 1 strain (namely PR40/2014) characterized by high pathogenicity was isolated and experimental infection was characterized in terms of virological/clinical features and immune modulation (Canelli et al. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00345288183159
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http://dx.doi.org/10.1016/j.rvsc.2019.04.007DOI Listing
April 2019
1 Read

The immunomodulatory effect of Poria cocos polysaccharides is mediated by the Ca/PKC/p38/NF-κB signaling pathway in macrophages.

Int Immunopharmacol 2019 Apr 16;72:252-257. Epub 2019 Apr 16.

Department of Clinical Laboratory, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address:

Poria cocos polysaccharide (PCP), extracted from Poria cocos sclerotium, has many biological activities. The present study explored the immunomodulatory effect and the underlying molecular mechanism of PCP in RAW 264.7 macrophages. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.017DOI Listing

CXCR6 deficiency ameliorates ischemia-reperfusion injury by reducing the recruitment and cytokine production of hepatic NKT cells in a mouse model of non-alcoholic fatty liver disease.

Int Immunopharmacol 2019 Apr 16;72:224-234. Epub 2019 Apr 16.

Department of Hepatic Surgery and Liver Transplantation Center of The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China. Electronic address:

Fatty liver is used for transplantation due to organ shortage, but prone to cause complications like ischemia-reperfusion injury (IRI). NKT cells as a bridge between innate and adaptive immunity were reported to infiltrate the liver at the early phase of IRI induced in normal liver. However, the localization mechanism of NKT cells is not precise, and the role of NKT cells in fatty liver IRI is poorly understood. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.021DOI Listing

Blinatumomab for Acute Lymphoblastic Leukemia Relapse After Allogeneic Hematopoietic Stem Cell Transplantation.

Biol Blood Marrow Transplant 2019 Apr 16. Epub 2019 Apr 16.

Medizinische Klinik und Poliklinik II, Universitätsklinikum Würzburg, Würzburg, Germany.

Patients with relapsed/refractory (R/R) acute lymphoblastic leukemia (ALL) following allogeneic hematopoietic stem cell transplantation (alloHSCT) have a poor prognosis, and alternative therapies are needed for this patient population. Blinatumomab, a bispecific T-cell engager immunotherapy, was evaluated in an open-label, single-arm, phase 2 study of adults with R/R Philadelphia chromosomenegative B-cell precursor ALL and resulted in a complete remission (CR) or CR with partial hematologic recovery of peripheral blood counts (CRh) rate of 43% within 2 treatment cycles. We conducted an exploratory analysis to determine the efficacy and safety of blinatumomab in 64 patients who had relapsed following alloHSCT prior to enrollment in the phase 2 study. Read More

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http://dx.doi.org/10.1016/j.bbmt.2019.04.010DOI Listing

Aryl quinolinyl hydrazone derivatives as anti-inflammatory agents that inhibit TLR4 activation in the macrophages.

Eur J Pharm Sci 2019 Apr 16. Epub 2019 Apr 16.

Bose Institute, Division of Molecular Medicine, P-1/12, C.I.T. Scheme VII M, Kolkata 700054, India. Electronic address:

A series of aryl 7-chloroquinolinyl hydrazone derivatives (3a-u) have been synthesized in 55-76% yield using simple reaction condition. The synthesized compounds were evaluated for their anti-inflammatory activities based on their ability to inhibit pro-inflammatory cytokine secretion from the macrophages after stimulation with lipopolysaccharide (LPS). Three compounds appeared as promising anti-inflammatory agents. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S09280987193015
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http://dx.doi.org/10.1016/j.ejps.2019.04.016DOI Listing
April 2019
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Baicalin tetrazole acts as anti-pneumocystis carinii pneumonia candidate in immunosuppressed rat model.

Microb Pathog 2019 Apr 16. Epub 2019 Apr 16.

Department of Laboratory Medicine, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, China. Electronic address:

The present study was aimed to synthesize and evaluate tetrazoles of baicalin against Pneumocystis carinii pneumonia in the rat model. Among the seven synthesized baicalin tetrazoles, one with trifloromethyl group in the aromatic ring was found to be most potent during the initial study. The mechanism of preventive effect of most potent compound 4c against Pneumocystis carinii pneumonia was investigated in detail. Read More

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http://dx.doi.org/10.1016/j.micpath.2019.04.027DOI Listing

Lung cancer-derived extracellular vesicles induced myotube atrophy and adipocyte lipolysis via the extracellular IL-6-mediated STAT3 pathway.

Biochim Biophys Acta Mol Cell Biol Lipids 2019 Apr 16. Epub 2019 Apr 16.

Department of Pathogenic Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei Province, China. Electronic address:

Cancer-associated cachexia (CAC) constitutes a metabolic dysfunction characterized by systemic inflammation and body weight loss. Muscle atrophy and adipose tissue lipolysis might explain weight loss in CAC. Specific functions of numerous hormones and cytokines derived from tumours can provoke cachexia. Read More

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http://dx.doi.org/10.1016/j.bbalip.2019.04.006DOI Listing

Effect of symbiotic supplemented diet on innate-adaptive immune response, cytokine gene regulation and antioxidant property in Labeo rohita against Aeromonas hydrophila.

Fish Shellfish Immunol 2019 Apr 16. Epub 2019 Apr 16.

Department of Herbal and Environmental Science, Tamil University, Thanjavur, 613 005, Tamil Nadu, India.

Administration of probiotic, prebiotic or symbiotic supplemented diets boosts the antioxidant property, pro and/or anti-inflammatory cytokine gene transcription, innate-adaptive immunity, growth rate and feed digestibility with very low or no mortality in healthy and infected (both groups) in Labeo rohita against Aeromonas hydrophila is reported. The probiotic diet increased the white blood cell (WBC) count and globulin (GB) level significantly on or after 6th week whereas with the symbiotic diet the increase was noted two weeks earlier in both groups; the total protein (TP) level also increased significantly when fed with probiotic diet on weeks 6 and 8, whereas with symbiotic diet the significant increase manifested earlier at 4th week itself. The serum phagocytic activity (PA), respiratory burst activity (RBA), complement C3 (CC3) level, alternative complement pathway (ACP), lysozyme activity (LA), and immunoglobulin M (IgM) levels in head kidney (HK) leucocytes increased significantly (P < 0. Read More

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http://dx.doi.org/10.1016/j.fsi.2019.04.036DOI Listing

Adiponectin as inducer of inflammatory and apoptosis involving in immune defense in lamprey.

Fish Shellfish Immunol 2019 Apr 16. Epub 2019 Apr 16.

College of Life Science, Liaoning Normal University, Dalian, 116081, China; Lamprey Research Center, Liaoning Normal University, Dalian, 116081, China. Electronic address:

Adiponectin (APN) is an important cytokine secreted by fat cells that is responsible for regulating numerous biological functions. However, the APN gene in lamprey and its precise function remain unidentified. In this study, the full-length cDNA sequence of L-APN was cloned, and it encoded a protein of 267 amino acid residues with a globular domain. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10504648193028
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http://dx.doi.org/10.1016/j.fsi.2019.04.045DOI Listing
April 2019
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Oxidative stress-induced senescence markedly increases disc cell bioenergetics.

Mech Ageing Dev 2019 Apr 16. Epub 2019 Apr 16.

Department of Orthopedic Surgery, University of Pittsburgh, 200 Lothrop Street, Pittsburgh, PA, 15213, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, 15213, USA. Electronic address:

Cellular senescence is a phenotype characterized by irreversible growth arrest, chronic elevated secretion of proinflammatory cytokines and matrix proteases, a phenomenon known as senescence associated secretory phenotype (SASP). Biomarkers of cellular senescence have been shown to increase with age and degeneration of human disc tissue. Senescent disc cells in culture recapitulate features associated with age-related disc degeneration, including increased secretion of proinflammatory cytokines, matrix proteases, and fragmentation of matrix proteins. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00476374183019
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http://dx.doi.org/10.1016/j.mad.2019.04.006DOI Listing
April 2019
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XPro1595 ameliorates bone cancer pain in rats via inhibiting p38-mediated glial cell activation and neuroinflammation in the spinal dorsal horn.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Department of Human Anatomy, Histology and Embryology & K.K. Leung Brain Research Centre, Preclinical School of Medicine, The Fourth Military Medical University, Xi'an 710032, PR China. Electronic address:

Bone cancer pain (BCP) profoundly compromises the life quality of patients with bone metastases. Severe side effects of the drugs which were widely used and effective in the various stages of this condition results in a huge challenge for BCP treatment. Here, we investigated the antinociceptive effects of XPro1595, a soluble tumor necrosis factor (solTNF) inhibitor with considerable immunoregulatory efficacy, on BCP, as well as the underlying mechanisms within the spinal dorsal horn (SDH). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183053
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.009DOI Listing
April 2019
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Insulin treatment protects the brain against neuroinflammation by reducing cerebral cytokines and modulating mitochondrial function.

Brain Res Bull 2019 Apr 16. Epub 2019 Apr 16.

Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, 88806-00 Criciúma, SC, Brazil. Electronic address:

In the central nervous system, glial cells protect the brain against neuronal stress by inducing inflammatory responses; namely, intracellular signaling and cytokine production. However, chronic inflammation is often associated with degenerative diseases that can damage hormone signaling and mitochondrial function. Lipopolysaccharide (LPS) induces neuroinflammation by stimulating the production of interleukin-1beta (IL-1β) and tumor necrosis factor-alpha (TNF-α); moreover, it generates oxidative stress and impairs cognitive functions. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03619230183094
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http://dx.doi.org/10.1016/j.brainresbull.2019.04.011DOI Listing
April 2019
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Anti-inflammatory effects of vanadium-binding protein from Halocynthia roretzi in LPS-stimulated RAW264.7 macrophages through NF-κB and MAPK pathways.

Int J Biol Macromol 2019 Apr 16. Epub 2019 Apr 16.

Department of Food Science and Biotechnology, Kyung Hee University, Yongin 17104, Republic of Korea; Skin Biotechnology Center, Kyung Hee University, Suwon 16229, Republic of Korea. Electronic address:

Vanadium-binding protein (VBP) was separated from the blood of the fresh sea urchin Halocynthia roretzi through (NH)SO precipitation, Diethylaminoethyl Sepharose fast-flow ion-exchange chromatography, and Sephacryl S-200 high-resolution size-exclusion chromatography. The protein size and purification yield of VBP were 27 kDa and 5.5%, respectively. Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.106DOI Listing

The RAG2 gene of yellow catfish (Tachysurus fulvidraco) and its immune response against Edwardsiella ictaluri infection.

Dev Comp Immunol 2019 Apr 16. Epub 2019 Apr 16.

Guangzhou Key Laboratory of Aquatic Animal Diseases and Waterfowl Breeding, College of Animal Sciences and Technology, Zhongkai University of Agriculture and Engineering, Guangzhou, Guangdong, 510225, China. Electronic address:

Recombination-activating gene 2 (rag 2) allies with recombination-activating gene 1 (rag 1) and regulates the V(D)J recombination of immunoglobulin (Ig) and T-cell receptor (TCR) genes. Being a key player in the adaptive immune response of vertebrates, functional characterization of rag 2 from yellow catfish is beneficial for understanding the biological response towards the pathogens. In this report, we have cloned and characterized the rag 2 gene of yellow catfish, and a particular pattern of expression was analysed in the major tissues of yellow catfish. Read More

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http://dx.doi.org/10.1016/j.dci.2019.04.006DOI Listing

TLR2 and TLR4 mediate an activation of adipose tissue renin-angiotensin system induced by uric acid.

Biochimie 2019 Apr 16. Epub 2019 Apr 16.

Department of Endocrinology, Central War Zone General Hospital of the Chinese People's Liberation Army, Wuhan, China.

Both hyperuricemia and adipose tissue renin-angiotensin system (RAS) are closely associated with multiple metabolic and cardiovascular diseases. We previously reported that uric acid could upregulate tissue RAS in adipocytes. In the present study, we aimed to reveal the involvement of toll-like receptors (TLRs) in uric acid-induced RAS activation in adipose tissue. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03009084193012
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http://dx.doi.org/10.1016/j.biochi.2019.04.013DOI Listing
April 2019
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Induction of innate cytokine responses by respiratory mucosal challenge with R848 in zebrafish, mice and humans.

J Allergy Clin Immunol 2019 Apr 16. Epub 2019 Apr 16.

Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, SW7 2AZ, UK. Electronic address:

We compared live zebrafish, mouse and human nasal challenge responses to the TLR7/8 agonist resiquimod (R848). We found remarkably similar induction of mediators in the three species, offering novel mucosal models of innate anti-viral immunity. Read More

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http://dx.doi.org/10.1016/j.jaci.2019.04.003DOI Listing

Impact of malaria and hepatitis B co-infection on clinical and cytokine profiles among pregnant women.

PLoS One 2019 19;14(4):e0215550. Epub 2019 Apr 19.

West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon- Accra, Ghana.

Background: The overlap of malaria and chronic hepatitis B (CHB) is common in endemic regions, however, it is not known if this co-infection could adversely influence clinical and immunological responses. This study investigated these interactions in pregnant women reporting to antenatal clinics in Ghana.

Methods: Clinical parameters (hemoglobin, liver function biomarker, peripheral malaria parasitemia, and hepatitis B viremia) and cytokine profiles were assayed and compared across four categories of pregnant women: un-infected, mono-infected with Plasmodium falciparum (Malaria group), mono-infected with chronic hepatitis B virus (CHB group) and co-infected (Malaria+CHB group). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215550PLOS

Preclinical evaluation of EPHX2 inhibition as a novel treatment for inflammatory bowel disease.

PLoS One 2019 19;14(4):e0215033. Epub 2019 Apr 19.

Computational Biology, GlaxoSmithKline, Collegeville, Pennsylvania, United States of America.

Epoxyeicosatrienoic acids (EETs) are signaling lipids produced by cytochrome P450 epoxygenation of arachidonic acid, which are metabolized by EPHX2 (epoxide hydrolase 2, alias soluble epoxide hydrolase or sEH). EETs have pleiotropic effects, including anti-inflammatory activity. Using a Connectivity Map (CMAP) approach, we identified an inverse-correlation between an exemplar EPHX2 inhibitor (EPHX2i) compound response and an inflammatory bowel disease patient-derived signature. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215033PLOS
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