773,991 results match your criteria Cytokine & Growth Factor Reviews [Journal]


Hepatic differentiation of human pluripotent stem cells by developmental stage-related metabolomics products.

Differentiation 2019 Jan 28;105:54-70. Epub 2019 Jan 28.

Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Diabetes Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Irwin S. and Sylvia Chanin Institute for Cancer Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Ruth L. and David S. Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address:

Endogenous cell signals regulate tissue homeostasis and are significant for directing the fate of stem cells. During liver development, cytokines released from various cell types are critical for stem/progenitor cell differentiation and lineage expansions. To determine mechanisms in these stage-specific lineage interactions, we modeled potential effects of soluble signals derived from immortalized human fetal liver parenchymal cells on stem cells, including embryonic and induced pluripotent stem cells. Read More

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http://dx.doi.org/10.1016/j.diff.2019.01.005DOI Listing
January 2019

Cytokines use different intracellular mechanisms to upregulate the membrane expression of CXCR1 in human monocytes.

Mol Immunol 2019 Feb 15;108:23-33. Epub 2019 Feb 15.

Laboratorio de Patogénesis e Inmunología de Procesos Infecciosos, Instituto de Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas- Academia Nacional de Medicina, Buenos Aires, Argentina. Electronic address:

Membrane expression of fractalkine (CXCL1)-receptor (CXCR1) is relevant in monocytes (Mo) because CXCR1-CXCL1 interactions might participate on both, homeostatic and pathologic conditions. We have previously demonstrated that CXCR1 levels are decreased during culture and when Mo are differentiated into dendritic cells, but enhanced when differentiated into macrophages. Regarding soluble factors, lipopolysaccharide (LPS) accelerated the loss of CXCR1, while interleukin (IL)-10 and Interferon-gamma (IFN-γ) prevented it. Read More

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http://dx.doi.org/10.1016/j.molimm.2019.01.003DOI Listing
February 2019

Growth and differentiation factor 15 is a biomarker for low back pain-associated disability.

Cytokine 2019 Feb 15;117:8-14. Epub 2019 Feb 15.

Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, 6905126 Tel-Aviv, Israel; Lilian and Marcel Pollak Chair of Biological Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, 6905126 Tel-Aviv, Israel. Electronic address:

The development of low back pain (LBP) is often associated with obesity and sarcopenia. However, the mechanisms of this association remain unclear. To clarify this, we measured circulating levels of a selected panel of soluble factors, presumably involved in obesity and sarcopenia pathogenesis, and correlated them with several LBP-related characteristics, taking into account body composition and other relevant covariates. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.011DOI Listing
February 2019

The senescence-associated secretory phenotype and its regulation.

Cytokine 2019 Feb 15;117:15-22. Epub 2019 Feb 15.

Department of Biochemistry and Molecular Medicine, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7, Canada; CRCHUM, 900 Saint-Denis - Room R10.432, Montréal, QC H2X 0A9, Canada. Electronic address:

The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context. The SASP reinforces the senescent cell cycle arrest, stimulates the immune-mediated clearance of potentially tumorigenic cells, limits fibrosis and promotes wound healing and tissue regeneration. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.013DOI Listing
February 2019

Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a.

Int Immunopharmacol 2019 Feb 15;69:373-381. Epub 2019 Feb 15.

Department of Orthopaedics, China-Japan Union Hospital of Jilin University, Changchun 130033, Jilin, China. Electronic address:

Kaempferol is a kind of bioflavonoid exerts diverse pharmacological activities, including anti-apoptotic and anti-inflammatory activities. Kaempferol has been recognized as an effective agent for alleviating the clinical symptoms of osteoarthritis (OA). This study aimed to provide evidence that Kaempferol has potential in the management of OA. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.02.014DOI Listing
February 2019

Plasma estradiol levels and antidepressant effects of omega-3 fatty acids in pregnant women.

Brain Behav Immun 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan; Division of Health Care Research, Center for Public Health Sciences, National Cancer Center Japan, Tokyo, Japan.

Background: Omega-3 polyunsaturated fatty acids (PUFAs) reduce depressive symptoms through an anti-inflammatory effect, and injection of both omega-3 PUFAs and estradiol (E2) induces antidepressant-like effects in rats by regulating the expression of inflammatory cytokines. The aims of this study were to examine the association of increased E2 during pregnancy with depressive symptoms and with inflammatory cytokines in women who were and were not supplemented with omega-3 PUFAs.

Methods: Pregnant women with Edinburgh Postnatal Depression Scale scores ≥ 9 were recruited at 12-24 weeks of gestation. Read More

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http://dx.doi.org/10.1016/j.bbi.2019.02.014DOI Listing
February 2019

Taxifolin protects neurons against ischemic injury in vitro via the activation of antioxidant systems and signal transduction pathways of GABAergic neurons.

Mol Cell Neurosci 2019 Feb 15. Epub 2019 Feb 15.

Institute of Cell Biophysics, Federal Research Center "Pushchino Scientific Center for Biological Research of the Russian Academy of Sciences", Russian Academy of Sciences, Russia. Electronic address:

Cerebral blood flow disturbances lead to the massive death of brain cells. The death of >80% of cells is observed in hippocampal cell cultures after 40 min of oxygen and glucose deprivation (ischemia-like conditions, OGD). However, there are some populations of GABAergic neurons which are characterized by increased vulnerability to oxygen-glucose deprivation conditions. Read More

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http://dx.doi.org/10.1016/j.mcn.2019.01.005DOI Listing
February 2019

Long-term stimulation of angiotensin II induced endothelial senescence and dysfunction.

Exp Gerontol 2019 Feb 15. Epub 2019 Feb 15.

State Key Laboratory of Cardiovascular Disease, FuWai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College, Chinese Academy of Medical Sciences, Beilishi Road 167, Xicheng District, Beijing 100037, China. Electronic address:

The role of angiotensin II (Ang II) in hypertension has been clarified, but recent studies show that aging-associated arterial changes and those with hypertension as well as atherosclerosis may have some common pathogenesis. This study aimed to clarify the effects of Ang II on endothelial senescence by establishing a replicative senescence model of human umbilical vein endothelial cells (HUVECs) in vitro. The population-doubling level (PDL) was calculated, PDL5 and PDL25 respectively referred to cells cultured for 2 days and 30 days. Read More

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http://dx.doi.org/10.1016/j.exger.2019.02.012DOI Listing
February 2019

MicroRNA-30c abrogation protects against spinal cord ischemia reperfusion injury through modulating SIRT1.

Eur J Pharmacol 2019 Feb 15. Epub 2019 Feb 15.

Spine area of orthopedics, Xi'an Hospital of Traditional Chinese Medicine, 710021, Shanxi, China. Electronic address:

Spinal cord ischemia/reperfusion (I/R) injury is a severe complication in many surgeries. Although microRNAs (miRNAs) are involved in I/R-caused spinal cord injury (SCI), the mechanism that underlies miR-30c interacted with SCI remains elusive. In this study, I/R surgery or oxygen-glucose deprivation (OGD) were performed to establish SCI model in vivo or in vitro, respectively. Read More

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http://dx.doi.org/10.1016/j.ejphar.2019.02.027DOI Listing
February 2019

Involvement of Stat3 phosphorylation in mild heat shock-induced thermotolerance.

Exp Cell Res 2019 Feb 15. Epub 2019 Feb 15.

Department of Biochemistry & Molecular Biology, Kyoto Pharmaceutical University, Kyoto 607-8414, Japan. Electronic address:

Thermotolerance is a phenomenon in which cells become resistant to stress by prior exposure to heat shock, and its development is associated with the induction of heat shock proteins (Hsps), including Hsp70. We previously showed that the expression of Hsp70 is regulated by the cytokine signaling transcription factor Stat3, but the role of Stat3 in thermotolerance is not known. In this study, we examined the possible involvement of Stat3 in the acquisition of thermotolerance. Read More

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http://dx.doi.org/10.1016/j.yexcr.2019.02.011DOI Listing
February 2019

ATP redirects cytokine trafficking and promotes novel membrane TNF signaling via microvesicles.

FASEB J 2019 Feb 18:fj201802386R. Epub 2019 Feb 18.

Section of Anaesthetics, Pain Medicine, and Intensive Care, Faculty of Medicine, Chelsea and Westminster Hospital, Imperial College London, London, United Kingdom.

Cellular stress or injury induces release of endogenous danger signals such as ATP, which plays a central role in activating immune cells. ATP is essential for the release of nonclassically secreted cytokines such as IL-1β but, paradoxically, has been reported to inhibit the release of classically secreted cytokines such as TNF. Here, we reveal that ATP does switch off soluble TNF (17 kDa) release from LPS-treated macrophages, but rather than inhibiting the entire TNF secretion, ATP packages membrane TNF (26 kDa) within microvesicles (MVs). Read More

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http://dx.doi.org/10.1096/fj.201802386RDOI Listing
February 2019

Recombinant human granulocyte- colony stimulating factor in women with unexplained recurrent pregnancy losses: a randomized clinical trial.

Hum Reprod 2019 Feb 18. Epub 2019 Feb 18.

Nora Therapeutics, Inc., 530 Lytton Avenue, 2nd Floor, Palo Alto, CA, USA.

Study Question: Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history of unexplained recurrent pregnancy loss?

Summary Answer: rhG-CSF administered in the first trimester of pregnancy did not improve outcomes among women with a history of unexplained recurrent pregnancy loss.

What Is Known Already: The only previous randomized controlled study of granulocyte colony stimulating factor in recurrent miscarriage in 68 women with unexplained primary recurrent miscarriage found a statistically significant reduction in miscarriage and improvement in live birth rates. A further four observational studies where G-CSF was used in a recurrent miscarriage population were identified in the literature, two of which confirmed statistically significant increase in clinical pregnancy and live birth rates. Read More

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http://dx.doi.org/10.1093/humrep/dey393DOI Listing
February 2019

Microencapsulated Immunoassays for Detection of Cytokines in Human Blood.

ACS Sens 2019 Feb 18. Epub 2019 Feb 18.

Department of Physiology and Biomedical Engineering , Mayo Clinic , Rochester Campus, Rochester , Minnesota 55905 , United States.

Cytokines are produced by leukocytes in blood and may be used as indicators of malignancies or infections. The objective of this study was to develop a strategy for immunosensing cytokines in whole, unprocessed human blood. Microfluidic droplet generation was employed to fabricate ∼400 μm diameter microcapsules with a hydrogel shell and an aqueous core containing sensing microbeads. Read More

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http://dx.doi.org/10.1021/acssensors.8b01033DOI Listing
February 2019

[Irisin as a new marker for the early diagnosis of low-traumatic fractures in rheumatoid arthritis.]

Klin Lab Diagn 2018 ;63(11):702-706

Volgograd State Medical University, 400131, Volgograd, Russian Federation.

The aim of this study was to study the relationship between serum irisin level and the presence of low-traumatic bone fractures in rheumatoid arthritis (RA) patients. We examined 170 people including 110 RA patients and 60 healthy individuals as comparison group. The serum irisin level was determined with solid-phase enzyme-linked immunosorbent assay using ELISA Irisin test system (BioVendor, cat. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-11-702-706DOI Listing
January 2018

[Biological function of endoecology (cleanliness of intercellular environment) realize two biolocical reactions: excretion reaction and inflammation reaction - utilization in vivo, in situ catabolites of the large molecular mass.]

Authors:
V N Titov

Klin Lab Diagn 2018 ;63(11):668-676

National Medical Research Center of Cardiology, Ministry of Health, 121552, Moscow, Russia.

For the biological functions of trophology (nutrition) and homeostasis, we believe that the third place is occupied by the function of endoecology: in a single pool of intercellular environment in vivo it must be "pure". The biological function of endoecology, realizes two biological reactions: the reaction of excretion and the reaction of inflammation. The biological reaction of excretion is the filtration of phlogogens of a small mol. Read More

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http://dx.doi.org/10.18821/0869-2084-2018-63-11-668-676DOI Listing
January 2018

Actual Anti-TNF Trough Levels Relate to Serum IL-10 in Drug-Responding Patients With Crohn's Disease.

Inflamm Bowel Dis 2019 Feb 19. Epub 2019 Feb 19.

CIBERehd, Instituto de Salud Carlos III, Madrid, Spain.

Background: Patients with Crohn's disease (CD) responding to anti-tumor necrosis factor (anti-TNF) show great variability in serum drug levels, even within the therapeutic range. We aimed at exploring the role of inflammatory, genetic, and bacterial variables in relation to anti-TNF through levels in CD patients.

Methods: Consecutive CD patients receiving stable doses of infliximab or adalimumab were included. Read More

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http://dx.doi.org/10.1093/ibd/izz012DOI Listing
February 2019

In silico characterization of microRNAs-like sequences in the genome of Paracoccidioides brasiliensis.

Genet Mol Biol 2019 Feb 14. Epub 2019 Feb 14.

Laboratório de Biologia Molecular, Instituto de Ciências Biológicas, Universidade Federal de Goiás, Campus II Samambaia, Goiânia, GO, Brazil.

Eukaryotic cells have different mechanisms of post-transcriptional regulation. Among these mechanisms, microRNAs promote regulation of targets by cleavage or degradation of the mRNA. Fungi of the Paracoccidioides complex are the etiological agents of the main systemic mycosis of Latin America. Read More

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http://dx.doi.org/10.1590/1678-4685-GMB-2018-0014DOI Listing
February 2019

Epithelial barrier repair and prevention of allergy.

J Clin Invest 2019 Feb 18. Epub 2019 Feb 18.

Division of Pediatric Allergy and Clinical Immunology, Department of Pediatrics, and.

Allergic diseases have in common a dysfunctional epithelial barrier, which allows the penetration of allergens and microbes, leading to the release of type 2 cytokines that drive allergic inflammation. The accessibility of skin, compared with lung or gastrointestinal tissue, has facilitated detailed investigations into mechanisms underlying epithelial barrier dysfunction in atopic dermatitis (AD). This Review describes the formation of the skin barrier and analyzes the link between altered skin barrier formation and the pathogenesis of AD. Read More

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http://dx.doi.org/10.1172/JCI124608DOI Listing
February 2019

Mesenchymal stem cells improve platelet counts in mice with immune thrombocytopenia.

J Cell Biochem 2019 Feb 18. Epub 2019 Feb 18.

Department of Hematology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.

Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. The breakdown of immune tolerance (regulatory T [Treg] cells and suppressor cytokines) plays an important role in ITP pathophysiology, especially in refractory ITP. Bone marrow-derived mesenchymal stem cells (BM-MSCs) show immunomodulatory properties and have been extensively utilized for autoimmune diseases. Read More

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http://dx.doi.org/10.1002/jcb.28405DOI Listing
February 2019

The association of Leptospermum honey with cytokine expression in the sinonasal epithelium of chronic rhinosinusitis patients.

World J Otorhinolaryngol Head Neck Surg 2019 Mar 7;5(1):19-25. Epub 2018 Sep 7.

St. Paul's Sinus Centre, Division of Otolaryngology, Department of Surgery, St. Paul's Sinus Centre, Vancouver, BC, Canada.

Objective: To identify the differences in cytokine expression between sinonasal tissue from patients treated with Leptospermum (Manuka) honey (LH) irrigation versus normal saline irrigation twice-daily for twelve weeks following sinus surgery (FESS).

Methods: Forty-six CRS patients were recruited. Sinus tissue biopsies were collected during FESS and then at 5 and 12 weeks postoperatively during the course of treatment. Read More

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http://dx.doi.org/10.1016/j.wjorl.2018.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364513PMC

Chemotherapy-related cognitive dysfunction and effects on quality of life in gynecologic cancer patients.

Expert Rev Qual Life Cancer Care 2018 26;3(1):19-26. Epub 2018 Feb 26.

Department of Neurology, Department of Neurological Surgery, and Chao Family Comprehensive Cancer Center, University of California Irvine, Irvine, CA, USA.

Introduction: chemotherapy-related cognitive dysfunction (CRCD) is a growing problem due to rising cancer rates and increasing numbers of cancer survivors. upwards of 70% of ovarian cancer patients report cognitive-changes following treatment for their cancer.

Areas Covered: the underlying mechanisms of CRCD are a subject of active research and debate. Read More

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http://dx.doi.org/10.1080/23809000.2018.1443811DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6377208PMC
February 2018

NDR2 promotes the antiviral immune response via facilitating TRIM25-mediated RIG-I activation in macrophages.

Sci Adv 2019 Feb 6;5(2):eaav0163. Epub 2019 Feb 6.

Institute of Immunology, School of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China.

Retinoic acid-inducible gene I (RIG-I), a pivotal cytosolic sensor, recognizes viral RNAs to initiate antiviral innate immunity. However, posttranslational regulation of RIG-I signaling is not well understood. We report here that nuclear Dbf2-related kinase 2 (NDR2) functions as a crucial positive regulator of the RIG-I-mediated antiviral immune response. Read More

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http://dx.doi.org/10.1126/sciadv.aav0163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365120PMC
February 2019

ENA-78 Is a Novel Predictor of Wound Healing in Patients with Diabetic Foot Ulcers.

J Diabetes Res 2019 15;2019:2695436. Epub 2019 Jan 15.

Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022 Hubei, China.

Objectives: Chronic foot ulceration is a severe complication of diabetes, driving morbidity and mortality. The aim of our study was to identify novel biomarkers of impaired wound healing in diabetic foot ulcers.

Methods: 109 patients with neuropathic diabetic foot ulcers and 30 burn victims otherwise healthy participated. Read More

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http://dx.doi.org/10.1155/2019/2695436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350601PMC
January 2019

Biomarkers in patients with mucopolysaccharidosis type II and IV.

Mol Genet Metab Rep 2019 Jun 5;19:100455. Epub 2019 Feb 5.

Nemours/Alfred I. duPont Hospital for Children, Wilmington, DE, United States.

Glycosaminoglycans (GAGs), dermatan sulfate (DS), heparan sulfate (HS), and keratan sulfate (KS), are the primary biomarkers in patients with mucopolysaccharidoses (MPS); however, little is known about other biomarkers. To explore potential biomarkers and their correlation with GAGs, blood samples were collected from 46 MPS II patients, 34 MPS IVA patients, and 5 MPS IVB patients. We evaluated the levels of 8 pro-inflammatory factors (EGF, IL-1β, IL-6, MIP-1α, TNF-α, MMP-1, MMP-2, and MMP-9), collagen type II, and DS, HS (HS0S, HSNS), and KS (mono-sulfated, di-sulfated) in blood. Read More

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http://dx.doi.org/10.1016/j.ymgmr.2019.100455DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365937PMC

Combination therapy with androgen deprivation for hormone sensitive prostate cancer: A new frontier.

Asian J Urol 2019 Jan 15;6(1):57-64. Epub 2018 Sep 15.

Department of Urology, University of Wisconsin-Madison, Madison, WI, USA.

Androgen deprivation therapy (ADT) has been the standard of care for the last 75 years in metastatic hormone sensitive prostate cancer (PCa). However, this approach is rarely curative. Recent clinical trials have demonstrated that ADT combined with other agents, notably docetaxel and abiraterone, lead to improved survival. Read More

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http://dx.doi.org/10.1016/j.ajur.2018.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6363606PMC
January 2019

CAR-T immunotherapy: how will it change treatment for acute lymphoblastic leukemia and beyond?

Expert Opin Orphan Drugs 2018 8;6(10):563-566. Epub 2018 Oct 8.

Department of Pediatrics and Carbone Comprehensive Cancer Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Introduction: The recent approval of CD19 chimeric antigen receptor (CAR) T cells for refractory or second relapse of B cell acute lymphoblastic leukemia (B-ALL) has led to a paradigm shift. Besides being an alternative to chemotherapy and antibody-based approaches, CAR-T cells have become the first successful example of "personalized medicine."

Areas Covered: In clinical trials, tisagenlecleucel demonstrated higher response rates than prior therapies, and led to durable remissions lasting up to years for some children. Read More

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http://dx.doi.org/10.1080/21678707.2018.1529562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375487PMC
October 2018

Synergistic cytoprotection by co-treatment with dexamethasone and rapamycin against proinflammatory cytokine-induced alveolar epithelial cell injury.

J Intensive Care 2019 7;7:12. Epub 2019 Feb 7.

1Department of Anesthesiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.

Background: One of the main pathophysiological manifestations during the acute phase of sepsis is massive production of proinflammatory mediators. Clinical trials involving direct suppression of inflammatory mediators to relieve organ dysfunction in sepsis have been extensively performed; however, the clinical outcomes of such trials remain far from satisfactory. Given the need for better sepsis treatments, we have screened various agents with anti-inflammatory properties for cytoprotective effects. Read More

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http://dx.doi.org/10.1186/s40560-019-0365-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367811PMC
February 2019
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The Relationship between Fatigue and Cytokine Levels in Patients with Acute Myeloid Leukemia.

Int J Hematol Oncol Stem Cell Res 2018 Oct;12(4):318-321

Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Cancer-related fatigue (CRF) is a very prominent complaint and disabling symptom in cancer patients probably influenced by endogenous cytokines. But, the published data on this subject are limited. We explored the relationship of cytokines such as tumor necrosis factor (TNF-α) and interleukin-6 (IL-6) with fatigue in patients with AML. Read More

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October 2018

Fibroblast-myofibroblast crosstalk after exposure to mesenchymal stem cells secretome.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S73-S79

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: The aim of the present study was to investigate the effect of human bone marrow-derived mesenchymal stem cells conditioned medium on fibroblast to myofibroblast differentiation.

Background: Mesenchymal stem cells have a long-term clinical application and widely have used in autoimmune disease and regenerative medicine. However, some MSCs derived cytokines such as TGF-β could have a dual role in suppression or progression of disease. Read More

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January 2018

Variants in two gene members of the TNF ligand superfamily and hepatitis C virus chronic disease.

Gastroenterol Hepatol Bed Bench 2018 ;11(Suppl 1):S66-S72

Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Aim: To assess the possible correlation between single nucleotide polymorphisms (SNPs) of two members of TNF ligand superfamily genes, tumor necrosis factor-α (TNF-α) and lymphotoxin-α (LTA), and HCV chronic disease.

Background: The causes of disease progression from hepatitis C virus (HCV) infection to chronic liver disease still remains unclear. Abnormal production of the cytokines alleged to be contributed to progression of the disease or viral persistence. Read More

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January 2018

The Human Endolymphatic Sac and Inner Ear Immunity: Macrophage Interaction and Molecular Expression.

Front Immunol 2018 1;9:3181. Epub 2019 Feb 1.

Section of Otolaryngology, Department of Surgical Sciences, Head and Neck Surgery, Uppsala University Hospital, Uppsala, Sweden.

The endolymphatic sac (ES) is endowed with a multitude of white blood cells that may trap and process antigens that reach the inner ear from nearby infection-prone areas, it thus serves as an immunologic defense organ. The human ES, and unexpectedly the rest of the inner ear, has been recently shown to contain numerous resident macrophages. In this paper, we describe ES macrophages using super-resolution structured fluorescence microscopy (SR-SIM) and speculate on these macrophages' roles in human inner ear defense. Read More

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http://dx.doi.org/10.3389/fimmu.2018.03181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367985PMC
February 2019

Deficiency in IL-33/ST2 Axis Reshapes Mitochondrial Metabolism in Lipopolysaccharide-Stimulated Macrophages.

Front Immunol 2019 1;10:127. Epub 2019 Feb 1.

Department of Hepatology, The First Hospital of Jilin University, Changchun, China.

The polarization and function of macrophages play essential roles in controlling immune responses. Interleukin (IL)-33 is a member of the IL-1 family that has been shown to influence macrophage activation and polarization, but the underlying mechanisms are not fully understood. Mitochondrial metabolism has been reported to be a central player in shaping macrophage polarization; previous studies have shown that both aerobic glycolysis and oxidative phosphorylation uniquely regulate the functions of M1 and M2 macrophages. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367255PMC
February 2019

The Immunology of Macrophage Activation Syndrome.

Front Immunol 2019 1;10:119. Epub 2019 Feb 1.

Pediatric Rheumatology, University of Alabama Birmingham, Birmingham, AL, United States.

Synonymous with secondary hemophagocytic lymphohistiocytosis, macrophage activation syndrome (MAS) is a term used by rheumatologists to describe a potentially life-threatening complication of systemic inflammatory disorders, most commonly systemic juvenile idiopathic arthritis (sJIA) and systemic lupus erythematosus (SLE). Clinical and laboratory features of MAS include sustained fever, hyperferritinemia, pancytopenia, fibrinolytic coagulopathy, and liver dysfunction. Soluble interleukin-2 receptor alpha chain (sCD25) and sCD163 may be elevated, and histopathology often reveals characteristic increased hemophagocytic activity in the bone marrow (and other tissues), with positive CD163 (histiocyte) staining. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367262PMC
February 2019

The Autoimmune Disorder Susceptibility Gene Restrains NK Cell Function in YTS NK Cell Line and Knockout Mice.

Front Immunol 2019 1;10:68. Epub 2019 Feb 1.

The Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.

locus polymorphisms have been associated with several autoimmune diseases. We overexpressed in YTS natural killer (NK) cells and observed reduced NK cell cytotoxicity and IFN-γ release, delayed dendritic cell (DC) maturation, decreased conjugate formation, cell-surface receptor downregulation and increased autophagy. In contrast, siRNA mediated knockdown resulted in increased NK cell cytotoxicity, reversal of receptor expression and disrupted mitophagy. Read More

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http://dx.doi.org/10.3389/fimmu.2019.00068DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367972PMC
February 2019

Cellular Mechanisms of Etrolizumab Treatment in Inflammatory Bowel Disease.

Front Pharmacol 2019 1;10:39. Epub 2019 Feb 1.

Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Kussmaul Campus for Medical Research and Translational Research Center, Erlangen, Germany.

Anti-integrin therapy is a new frontline strategy in the treatment of inflammatory bowel diseases (IBD). The anti-β7 integrin antibody etrolizumab is currently being investigated for safety and efficacy in Crohn's disease (CD) and ulcerative colitis (UC) in several phase III trials. Mechanistically, etrolizumab is known to block β7 integrin ligand binding and reduces intestinal trafficking of β7-expressing cells. Read More

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http://dx.doi.org/10.3389/fphar.2019.00039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367223PMC
February 2019

Zinc Improves Functional Recovery by Regulating the Secretion of Granulocyte Colony Stimulating Factor From Microglia/Macrophages After Spinal Cord Injury.

Front Mol Neurosci 2019 1;12:18. Epub 2019 Feb 1.

Department of Orthopedics, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, China.

While zinc promotes motor function recovery after spinal cord injury (SCI), the precise mechanisms involved are not fully understood. The present study aimed to elucidate the effects of zinc and granulocyte colony stimulating factor (G-CSF) on neuronal recovery after SCI. The SCI model was established by Allen's method. Read More

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http://dx.doi.org/10.3389/fnmol.2019.00018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6367229PMC
February 2019

Enhanced efficacy of chemically modified curcumin in experimental periodontitis: systemic implications.

J Exp Pharmacol 2019 23;11:1-14. Epub 2019 Jan 23.

Department of General Dentistry, School of Dental Medicine, Stony Brook University, Stony Brook, NY, USA,

Introduction: Dental microbial biofilm initiates gingival inflammation, and its suppression is the current dominant strategy for treating periodontitis. However, the host response to the biofilm is largely responsible for the connective tissue breakdown including alveolar bone loss, which is mediated by proinflammatory cytokines and matrix metalloproteinases (MMPs).

Methods: The current study compared the efficacy of a novel host-modulation compound, a chemically modified curcumin (CMC 2. Read More

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http://dx.doi.org/10.2147/JEP.S171119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350653PMC
January 2019

Pro-inflammatory agents released by pathogens, dying host cells, and neutrophils act synergistically to destroy host tissues: a working hypothesis.

J Inflamm Res 2019 23;12:35-47. Epub 2019 Jan 23.

Department of Pathology, The University of Michigan Medical School, Ann Arbor, MI, USA.

We postulate that the extensive cell and tissue damage inflicted by many infectious, inflammatory and post-inflammatory episodes is an enled result of a synergism among the invading microbial agents, host neutrophils and dead and dying cells in the nidus. Microbial toxins and other metabolites along with the plethora of pro-inflammatory agents released from activated neutrophils massively recruited to the infectious sites and high levels of cationic histones, other cationic peptides, proteinases and Th1 cytokines released from activated polymorphonuclear neutrophils (PMNs) and from necrotized tissues may act in concert (synergism) to bring about cell killing and tissue destruction. Multiple, diverse interactions among the many potential pro-inflammatory moieties have been described in these complex lesions. Read More

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http://dx.doi.org/10.2147/JIR.S190007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350637PMC
January 2019

Effects of triptolide and methotrexate nanosuspensions on left ventricular remodeling in autoimmune myocarditis rats.

Int J Nanomedicine 2019 29;14:851-863. Epub 2019 Jan 29.

Department of Chemical Engineering, Northeastern University, Boston, MA 02115, USA,

Purpose: This study was carried out to investigate the effects of a triptolide (TP) nanosuspension and methotrexate (MTX) nanosuspension on left ventricular remodeling and cardiac function for autoimmune myocarditis (EAM) in rats. The regulating effects on inflammatory cytokines in the peripheral serum and related mechanisms are also discussed.

Methods: First, TP and MTX were prepared as a nanosuspension, and the EAM model was successfully established in rats with cardiac myosin. Read More

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http://dx.doi.org/10.2147/IJN.S191267DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6361222PMC
January 2019

Genetic polymorphisms near IL-21 gene associated with Th17 cytokines confer risk for systemic lupus erythematosus in Chinese Han population.

Lupus 2019 Feb 18:961203319829821. Epub 2019 Feb 18.

1 Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu, China.

Objective: Interleukin-21 (IL-21) contributes to expansion, differentiation, and modulation of various immunocompetent cells. Deregulated production of IL-21 plays a role of cardinal significance in the pathogenesis of systemic lupus erythematosus (SLE). We aimed to determine whether single nucleotide polymorphisms (SNP) near the IL-21 gene have significant association with SLE susceptibility and the T helper-related inflammatory cytokine profile of SLE patients. Read More

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http://dx.doi.org/10.1177/0961203319829821DOI Listing
February 2019

Prebiotic oligosaccharides in early life alter gut microbiome development in male mice while supporting influenza vaccination responses.

Benef Microbes 2019 Feb 18:1-14. Epub 2019 Feb 18.

2 Danone Nutricia Research, Department of Immunology / Microbiology, Uppsalalaan 12, 3584 CT Utrecht, the Netherlands.

Beneficial modulation of the gut microbiota is an attractive therapeutic approach to improve the efficacy of vaccine-induced immunity. In this study, mice were supplemented with the prebiotic milk oligosaccharide 2'-fucosyllactose (2'FL) as well as a complex mixture of immune modulatory prebiotic short-chain galacto-oligosaccharides and long-chain fructo-oligosaccharides (scGOS/lcFOS) from different stages in early life. Adult mice were vaccinated with trivalent influenza vaccine (TIV) and both development of the gut microbiota and antibody-mediated vaccine responses were followed over time. Read More

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http://dx.doi.org/10.3920/BM2018.0098DOI Listing
February 2019

Identification of potential CRAC channel inhibitors: Pharmacophore mapping, 3D-QSAR modelling, and molecular docking approach.

SAR QSAR Environ Res 2019 Feb 18:1-28. Epub 2019 Feb 18.

a Ion Channel Biology Laboratory, AU-KBC Research Centre, Madras Institute of Technology, Anna University , Chennai , India.

Upregulation of store-operated Ca influx via ORAI1, an integral component of the CRAC channel, is responsible for abnormal cytokine release in active rheumatoid arthritis, and therefore ORAI1 has been proposed as an attractive molecular target. In this study, we attempted to predict the mechanical insights of ORAI1 inhibitors through pharmacophore modelling, 3D-QSAR, molecular docking and free energy analysis. Various hypotheses of pharmacophores were generated and from that, a pharmacophore hypothesis with two hydrogen bond acceptors, one hydrogen bond donor and two aromatic rings (AADRR) resulted in a statistically significant 3D-QSAR model (r = 0. Read More

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http://dx.doi.org/10.1080/1062936X.2019.1566172DOI Listing
February 2019

[Current situation and thinking on the intestinal microflora regulation with acupuncture and moxibustion].

Zhen Ci Yan Jiu 2019 Jan;44(1):71-4

Union Hospital Affiliated to Tongji Medical College of Huazhong Science and Technology University, Wuhan 430022.

Large number of microflora is parasitized in the human intestinal tract, which maintains the stability of the microecological environment in the host's intestinal tract and the healthy state of the body. Once the steady state is out of balance, the intestinal microflora is dysfunctional and a variety of diseases will be induced. Acupuncture and moxibustion have a positive role in improving different types of clinical problems by regulating , harmonizing and , and strengthening the body's resistance. Read More

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http://dx.doi.org/10.13702/j.1000-0607.180118DOI Listing
January 2019

Inflammatory biomarkers, vascular procedures of lower limbs, and wound healing.

Int Wound J 2019 Feb 17. Epub 2019 Feb 17.

Department of Vascular and Endovascular Surgery, Centre Hospitalier Sud Francilien, Paris, France.

Abnormal, persistent inflammation after bypass surgery could prevent healing of an ischaemic foot lesion. In 37 patients with peripheral arterial disease (PAD) (Rutherford Grade III Category 5) who underwent infrapopliteal vein graft and midfoot amputation, plasma levels of fibrinogen, C-reactive protein (CRP), interleukin-1 (IL-1), interleukin-6 (IL-6), tumour necrosis factor-α (TNF-α), and matrix metalloproteinase-2 and -9 (MMP-2 and MMP-9) were determined preoperatively and during the follow up. Nine patients without clinical and Doppler evidence of arterial disease, who underwent post-traumatic midfoot primary amputation, were included in the experiment group, and 15 age-matched healthy volunteers served as control. Read More

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http://dx.doi.org/10.1111/iwj.13086DOI Listing
February 2019

Higher serum levels of systemic inflammatory markers are linked to greater inspiratory muscle dysfunction in copd.

Clin Respir J 2019 Feb 18. Epub 2019 Feb 18.

Department of Physical Therapy, University of Miami Miller School of Medicine, Coral Gables, FL - United States.

Background: COPD is associated with an inflammatory response that becomes more pronounced in acute exacerbations. Considerable attention has recently focused on the value of several inflammatory mediators in predicting worsening of COPD-related symptoms. Whereas respiratory muscle dysfunction is also widely present in this population, little is known about how systemic inflammation relates to inspiratory muscle dysfunction in COPD. Read More

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http://dx.doi.org/10.1111/crj.13006DOI Listing
February 2019

The angiotensin-(1-7)/Mas receptor axis protects from endothelial cell senescence via klotho and Nrf2 activation.

Aging Cell 2019 Feb 17:e12913. Epub 2019 Feb 17.

Department of Pharmacology, Faculty of Medicine, Universidad Autónoma de Madrid, Madrid, Spain.

Endothelial cell senescence is a hallmark of vascular aging that predisposes to vascular disease. We aimed to explore the capacity of the renin-angiotensin system (RAS) heptapeptide angiotensin (Ang)-(1-7) to counteract human endothelial cell senescence and to identify intracellular pathways mediating its potential protective action. In human umbilical vein endothelial cell (HUVEC) cultures, Ang II promoted cell senescence, as revealed by the enhancement in senescence-associated galactosidase (SA-β-gal+) positive staining, total and telomeric DNA damage, adhesion molecule expression, and human mononuclear adhesion to HUVEC monolayers. Read More

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http://dx.doi.org/10.1111/acel.12913DOI Listing
February 2019

Daily Variation in Macrophage Phagocytosis is Clock-independent and Dispensable for Cytokine Production.

Immunology 2019 Feb 18. Epub 2019 Feb 18.

Immunoregulation Section, Autoimmunity Branch, NIAMS, National Institutes of Health, Bethesda, MD, 20892, USA.

Innate immune responses vary in a circadian manner, and more recent investigations aim to understand the underlying molecular mechanisms. Cytokine production varies significantly over the course of a day depending on the time of stimulation by pathogens or Toll-Like Receptor ligands, and multiple signalling pathways linked to the cell-autonomous circadian clock modulate innate immunity. Recognition of foreign material, especially by innate immune cells, engages a myriad of receptors which trigger inflammatory responses, as well as endocytosis and degradation and/or processing for antigen presentation. Read More

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http://dx.doi.org/10.1111/imm.13053DOI Listing
February 2019

Effect of prenatal exposure to combined immunosuppressive agrochemicals in a mouse model of allergic airway inflammation.

J Vet Med Sci 2019 Feb 15. Epub 2019 Feb 15.

The Institute of Environmental Toxicology.

The aim of this study is to identify the combined effect of multiple chemicals to the development of allergy. In this study, the effect of prenatal exposure to an organochlorine agent methoxychlor (MXC) and/or an organophosphate agent parathion (PARA) on trimellitic anhydride-induced allergic airway inflammation was examined in mice. Eosinophil infiltration in the bronchoalveolar lavage fluid (BALF) was significantly enhanced by MXC+PARA exposure compared to that of the control, MXC, and PARA groups. Read More

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http://dx.doi.org/10.1292/jvms.18-0641DOI Listing
February 2019

Interleukin-17: The Role for Pathological Angiogenesis in Ocular Neovascular Diseases.

Tohoku J Exp Med 2019 ;247(2):87-98

Department of Ophthalmology, The Second Xiangya Hospital, Central South University.

Ocular neovascular diseases are featured by abnormal angiogenesis in the eye, and they seriously threaten the human visual health. These diseases include proliferative diabetic retinopathy (PDR), age-related macular degeneration (AMD), retinopathy of prematurity (ROP), and retinal vein occlusion (RVO). In fact, ocular neovascular diseases represent the leading causes of vision impairment and blindness worldwide. Read More

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http://dx.doi.org/10.1620/tjem.247.87DOI Listing
January 2019

DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma.

EBioMedicine 2019 Feb 14. Epub 2019 Feb 14.

Department of Neurosurgery, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China; Neuroscience Institute, Heilongjiang Academy of Medical Sciences, Harbin 150086, China. Electronic address:

Background: DNA damage repair (DDR) alterations are important events in cancer initiation, progression, and therapeutic resistance. However, the involvement of DDR alterations in glioma malignancy needs further investigation. This study aims to characterize the clinical and molecular features of gliomas with DDR alterations and elucidate the biological process of DDR alterations that regulate the cross talk between gliomas and the tumor microenvironment. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.01.067DOI Listing
February 2019
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