5,355 results match your criteria Cytokine [Journal]


Exercise-induced anti-inflammatory effects in overweight/obese women with polycystic ovary syndrome.

Cytokine 2019 Apr 18;120:66-70. Epub 2019 Apr 18.

Applied Physiology & Nutrition Research Group, Laboratory of Assessment and Conditioning in Rheumatology, School of Physical Education and Sport, School of Medicine, University of São Paulo, Brazil; Rheumatology Division, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, Brazil. Electronic address:

Polycystic ovary syndrome (PCOS) is characterized by exacerbated inflammation, which is implicated in cardiometabolic dysfunction. This study aimed to examine the potential effects of acute exercise on inflammatory responses in obese/overweight PCOS women and their controls. Participants underwent a single bout of moderate-intensity aerobic exercise (30 min at ∼65% of VO). Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.006DOI Listing

Variations of salivary concentration of cytokines and chemokines in presence of oral squamous cell carcinoma. A case-crossover longitudinal prospective study.

Cytokine 2019 Apr 18;120:62-65. Epub 2019 Apr 18.

University of Turin, Department of Oncology, Unit of Oral Medicine and Oral Oncology, Italy.

Salivary biomarkers represent a promising diagnostic tool. Non-invasive and stress-free sampling results in objective parameters able to overcome the need of clinical expertise required for a correct interpretation of early oral squamous cell carcinoma (OSCC). The present study aims at evaluating potential variations in the salivary concentration of cytokines in presence of OSCC. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.009DOI Listing

Development of a C1q-immobilized (Cim) assay to measure total antibodies to infliximab and its clinical relevance in patients with inflammatory bowel disease.

Cytokine 2019 Apr 16;120:54-61. Epub 2019 Apr 16.

IBD Centre, Toho University Sakura Medical Centre, Chiba, Japan. Electronic address:

Objective: Determination of antibodies to infliximab (ATI) is desirable for the management of patients with inflammatory bowel disease (IBD) who receive infliximab. Conventional ligand-binding ATI-assays detect only free-form of ATI, potentially increasing the proportion of patients with undetectable ATI, but with adequate trough infliximab (TRI) level who experience loss of response (LOR) to infliximab. We investigated this assertion using a novel ATI-Cim assay. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.014DOI Listing

MicroRNA-181b-5p attenuates early postoperative cognitive dysfunction by suppressing hippocampal neuroinflammation in mice.

Cytokine 2019 Apr 16;120:41-53. Epub 2019 Apr 16.

Department of Anesthesiology, Zhongnan Hospital of Wuhan University, 169 Donghu Road, Wuhan, Hubei, China. Electronic address:

Background: Postoperative cognitive dysfunction (POCD) is a common complication after surgery and its occurrence is associated with increased morbidity and mortality. However, the pathophysiology of this complication remains largely unknown. Efforts to identify causes of POCD have focused on the hippocampal neuroinflammation. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666193010
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http://dx.doi.org/10.1016/j.cyto.2019.04.005DOI Listing
April 2019
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Chicken viperin inhibits Newcastle disease virus infection in vitro: A possible interaction with the viral matrix protein.

Cytokine 2019 Apr 16;120:28-40. Epub 2019 Apr 16.

Department of Biosciences and Bioengineering, Indian Institute of Technology Guwahati, Guwahati, Assam 781039, India. Electronic address:

Viperin is an interferon-inducible protein that helps in protecting mammals against various virus infections. Viperin is a highly conserved member of the interferon-stimulated genes (ISG) family in many species. Viperin has been shown to play a pivotal role in the innate immunity of chicken; however, its role has not been explored in its antiviral potential. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.007DOI Listing

Interleukin-18 serum levels in sepsis: Correlation with disease severity and inflammatory markers.

Cytokine 2019 Apr 16;120:22-27. Epub 2019 Apr 16.

Department of Anesthesiology and Intensive TherapyCare, 4th Military Hospital of Wroclaw, Weigla 5, 50-981 Wroclaw, Poland; Faculty of Health Science, Wroclaw Medical University, Wroclaw, Poland. Electronic address:

Purpose: Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection and a syndrome shaped by pathogen and host factors with characteristic that evolve over time. The study was conducted to evaluate the prognostic and discriminative value of IL-18 assessment in comparison to PCT, CRP, WBC in early stage of sepsis and septic shock.

Methods: An observational and prospective study was conducted in the group of 40 ICU patients with diagnosis of sepsis or septic shock, serum PCT, IL-18, CRP and WBC measurements were performed on admission, and on the 2nd, 3rd and 5th therapy day. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666193010
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http://dx.doi.org/10.1016/j.cyto.2019.04.003DOI Listing
April 2019
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Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia.

Cytokine 2019 Apr 16;119:202-213. Epub 2019 Apr 16.

Institute of Pharmacology, Polish Academy of Sciences, Department of Pain Pharmacology, Krakow, Poland. Electronic address:

The complex neuroimmunological interactions mediated by chemokines are suggested to be responsible for the development of neuropathic pain. The lack of knowledge regarding the detailed pathomechanism of neuropathy is one reason for the lack of optimally efficient therapies. Recently, several lines of evidence indicated that expression of CCR2 is increased in spinal cord neurons and microglial cells after peripheral nerve injury. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.007DOI Listing

IL 6 but not TNF is linked to coronary artery calcification in patients with chronic kidney disease.

Cytokine 2019 Apr 13;120:9-14. Epub 2019 Apr 13.

Department of Immunology, Transplantology and Internal Diseases, Medical University of Warsaw, Nowogrodzka 59, 02-006 Warszawa, Poland. Electronic address:

Introduction: Patients with chronic kidney disease (CKD) have a high risk of death mainly due to cardiovascular diseases (CVD). Early risk identification may allow interventions and prevention of fatal events.

Objectives: The study aim was to assess the usefulness of selected CVD biomarkers as predictors of 5-year mortality in patients with different CKD stages. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.002DOI Listing
April 2019
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Poxviral E3L ortholog (Viral Interferon resistance gene) of orf viruses of sheep and goats indicates species-specific clustering with heterogeneity among parapoxviruses.

Cytokine 2019 Apr 13;120:15-21. Epub 2019 Apr 13.

Division of Virology, ICAR-IVRI, Mukteswar 263 138, Nainital, Uttarakhand, India. Electronic address:

Orf is a contagious disease posing a serious threat to animal and human health. E3L is one of the evolutionarily acquired immunomodulatory proteins present in orf virus (ORFV) and is responsible for conferring resistance to interferons among poxviruses. Genetic analysis of ORFV isolates of different geographical regions including Indian subcontinent targeting viral interferon resistance (VIR) gene (a homolog of vaccinia virus E3L gene) revealed a high percentage of identity among themselves and other ORFV isolates at both nt and aa levels as compared to low identity among parapoxviruses (PPVs). Read More

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http://dx.doi.org/10.1016/j.cyto.2019.04.001DOI Listing
April 2019
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Synergistic effects of recombinant Lentiviral-mediated BMP2 and TGF-beta3 on the osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro.

Cytokine 2019 Apr 13;120:1-8. Epub 2019 Apr 13.

Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address:

Background: Bone marrow mesenchymal stem cells (BMSCs) are considered good candidates for seed cells in bone engineering. The study aim to investigate the synergistic effects of human bone morphogenetic protein 2 (hBMP2) and transforming growth factor beta3 (hTGF-beta3) modified BMSCs on inducing osteogenic differentiation in vitro.

Methods: Lentivirus (LV) carrying hBMP2 and/or hTGF-beta3 genes were constructed and used to transduce rat BMSCs. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.020DOI Listing
April 2019
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Pentraxin-3 in coronary artery disease: A meta-analysis.

Cytokine 2019 Apr 4;119:197-201. Epub 2019 Apr 4.

Department of Cardiology, The Second Affiliated Hospital of Air Force Medical University, Xi'an 710038, PR China. Electronic address:

Aims: Studies on the prognostic significance of circulating pentraxin-3 level in patients with coronary artery disease (CAD) have yielded conflicting results. The aim of this meta-analysis was to evaluate the prognostic value of circulating pentraxin-3 level in CAD patients.

Materials/methods: We made a systematic literature search in Pubmed, Embae, CNKI, Wanfang, and VIP database from their inception to January 10, 2019 for prospective cohort studies that investigated the association between pentraxin-3 level and adverse outcomes in patients with CAD. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.017DOI Listing
April 2019
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Serum cytokine patterns in first half of pregnancy.

Cytokine 2019 Apr 3;119:188-196. Epub 2019 Apr 3.

Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway; Centre of Molecular Inflammation Research (CEMIR), Norwegian University of Science and Technology (NTNU), 7491 Trondheim, Norway.

Introduction: Human pregnancy is a state of elevated maternal systemic inflammation, and pregnancy complications are often associated with a dysfunctional immune response. The network of cytokines reflects this complex immune activity, and broad serum cytokine profiling provides a new tool to understand the changes in immune status during pregnancy.

Objective: This study aimed to determine how maternal serum cytokine patterns change during the first half of pregnancy. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.013DOI Listing

Clinical significance of serum CXCL9 levels as a biomarker for systemic juvenile idiopathic arthritis associated macrophage activation syndrome.

Cytokine 2019 Apr 2;119:182-187. Epub 2019 Apr 2.

Department of Pediatrics, Graduate School of Medical Sciences, Kanazawa University, Japan.

To clarify cytokines involved in the development of systemic juvenile idiopathic arthritis (s-JIA) associated macrophage activation syndrome (MAS) and to identify the serum biomarkers for the diagnosis of s-JIA associated MAS, we employed an antibody array that simultaneously detects 174 cytokines. Fifteen s-JIA patients including 5 patients receiving tocilizumab (TCZ) were analyzed. The levels of five cytokines were significantly elevated in MAS phase compared to those in the active phase of s-JIA. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.018DOI Listing

Extracellular ATP activates P2X7R-NF-κB (p65) pathway to promote the maturation of bone marrow-derived dendritic cells of mice.

Cytokine 2019 Apr 2;119:175-181. Epub 2019 Apr 2.

Department of Ophthalmology, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China. Electronic address:

The maturation state of dendritic cell (DC) plays an important role in immune activities. Previously we had found that NF-κB (p65) pathway could promote DC maturation and subsequent immune effects. But the upstream mechanism of this pathway was still unclear. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.019DOI Listing
April 2019
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Resistin up-regulates LPL expression through the PPARγ-dependent PI3K/AKT signaling pathway impacting lipid accumulation in RAW264.7 macrophages.

Cytokine 2019 Mar 26;119:168-174. Epub 2019 Mar 26.

Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Huimin road 211, 611130, China. Electronic address:

Resistin is a cysteine-rich cytokine, which has been indicated as a mediator of insulin resistance and inflammation. Previous studies demonstrated that lipoprotein lipase (LPL) was an important enzyme that could mediate lipid accumulation in macrophages. Additionally, the intracellular molecules phosphatidylinositol 3-kinase (PI3K)/serine-threonine protein kinase (AKT)/peroxisome proliferator-activated receptor (PPARγ) were supposed to be involved in the lipid accumulation process in cells. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.016DOI Listing

IL-33 contributes to disease severity in Psoriasis-like models of mouse.

Cytokine 2019 Mar 22;119:159-167. Epub 2019 Mar 22.

Department of Dermatology, The First Affiliated Hospital of Xinxiang Medical University, Henan, Xinxiang 453000, China. Electronic address:

Immune cells infiltrating the psoriatic skin secrete high amounts of pro-inflammatory cytokines IL-17, TNF-α, IL-21 and IL-36 resulting in chronic inflammation. However, the exact cellular and molecular mechanisms have not been fully understood. We report here elevation of IL-33 expression in psoriatic lesions. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.019DOI Listing
March 2019
2 Reads

Increased expression of IL-32 correlates with IFN-γ, Th1 and Tc1 in virologically suppressed HIV-1-infected patients.

Cytokine 2019 Mar 22. Epub 2019 Mar 22.

Laboratory of Virology, Department of Molecular Medicine, Affiliated to Istituto Pasteur Italia - Cenci Bolognetti Foundation, Sapienza University of Rome, Rome, Italy. Electronic address:

Following recent attention focused on IL-32 as an important component involved in the inflammatory cytokine network, we speculated that IL-32's action on IFN-γ and IFN-γ secreting T cell subsets may help sustain the immune activation and dysregulation found in patients with HIV-1 achieving viral suppression. To explore this hypothesis, transcript levels of IL-32 and IFN-γ were evaluated in PBMC from 139 virologically suppressed HIV-1-infected patients and from 63 healthy individuals by Real Time RT-PCR assays. IL-32 and IFN-γ mRNA levels were also analyzed in CD4+ T cells, CD14+ monocytes and lamina propria lymphocytes (LPL) of the gut district in a subgroup of HIV-1-infected subjects. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.012DOI Listing
March 2019
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Nucleic acid cytokine responses in obese children and infants of obese mothers.

Cytokine 2019 Mar 22;119:152-158. Epub 2019 Mar 22.

National Children's Research Centre, Crumlin, Dublin 12, Ireland; School of Medicine, Trinity College Dublin, Dublin 2, Ireland. Electronic address:

Almost a third of Irish children are now overweight and the country ranks 58th out of 200 countries for its proportion of overweight youths. With the rising obesity epidemic, and the impaired immune responses of this population, it is vital to understand the effects that obesity has on the immune system and to design future therapeutics, adjuvants and vaccines with overweight and obese populations in mind. Many current vaccines use adjuvants that have been found to be less effective at stimulating the immune response in children compared with adults and there is now substantial effort to design paediatric-focused adjuvants. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.015DOI Listing
March 2019
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Circulatory Omentin-1 levels but not genetic variants influence the pathophysiology of Type 2 diabetes.

Cytokine 2019 Mar 23;119:144-151. Epub 2019 Mar 23.

Department of Biochemistry, Faculty of Science, The Maharaja Sayajirao University of Baroda, Vadodara 390002, Gujarat, India. Electronic address:

Objective: Omentin-1, an anti-inflammatory protein, is secreted by the visceral adipose tissue. Altered levels of Omentin-1 are associated with obesity and Type 2 Diabetes (T2D). Although Omentin-1 is implicated in the insulin signaling pathway, the relationship between the genetic variants of Omentin-1 and T2D is not yet explored. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.011DOI Listing
March 2019
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Tinkering with targeting nucleotide signaling for control of intracellular Leishmania parasites.

Cytokine 2019 Mar 22;119:129-143. Epub 2019 Mar 22.

Department of Zoology, Karnatak University, Dharwad, Karnataka, India.

Nucleotides are one of the most primitive extracellular signalling molecules across all phyla and regulate a multitude of responses. The biological effects of extracellular nucleotides/sides are mediated via the specific purinergic receptors present on the cell surface. In mammalian system, adenine nucleotides are the predominant nucleotides found in the extracellular milieu and mediate a constellation of physiological functions. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.005DOI Listing
March 2019
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In vitro cellular responses to Neospora caninum glycosylphosphatidylinositols depend on the host origin of antigen presenting cells.

Cytokine 2019 Mar 22;119:119-128. Epub 2019 Mar 22.

ISP, INRA, Université Tours, 37380 Nouzilly, France. Electronic address:

Neosporosis due to Neospora caninum causes abortions in farm animals such as cattle. No treatment and vaccine exist to fight this disease, responsible for considerable economic losses. It is thus important to better understand the immune responses occurring during the pathogenesis to control them in a global strategy against the parasite. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.014DOI Listing

Interferon (IFN)-inducible Absent in Melanoma 2 proteins in the negative regulation of the type I IFN response: Implications for lupus nephritis.

Cytokine 2019 Mar 20. Epub 2019 Mar 20.

Department of Environmental Health, University of Cincinnati, 160 Panzeca Way, P.O. Box-670056, Cincinnati, OH 45267, United States; Research Service, ML-151, Cincinnati VA Medical Center, 3200 Vine Street, Cincinnati, OH 45220, United States.

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that exhibits a strong female bias (female-to-male ratio 9:1) in patients. Further, 40-60% SLE patients develop lupus nephritis (LN), which significantly increases the mortality rates. The failure of current therapies to adequately treat LN in patients reflects an incomplete understanding of the disease pathogenesis. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.008DOI Listing
March 2019
2 Reads

Inflammatory chemokine profiles and their correlations with effector CD4 T cell and regulatory cell subpopulations in cutaneous lupus erythematosus.

Cytokine 2019 Mar 20;119:95-112. Epub 2019 Mar 20.

Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición, Vasco de Quiroga No. 15, Colonia Belisario Domínguez Sección XVI, 14080 Mexico City, Mexico. Electronic address:

We compared the chemokine/receptor expression in skin biopsies of discoid (SLE/DLE) and subacute lupus (SLE/SCLE) and correlated it with tissue and circulating effector CD4 T cells/regulatory cells. Skin biopsies and peripheral blood from 9 active SLE/DLE patients, 9 SLE/SCLE patients, 5 control SLE patients without cutaneous lesions and 10 control healthy donors were included. Clinical skin activity was measured by Cutaneous Lupus Erythematosus Disease Area and Severity Index scoring, and systemic activity was measured by a modified SLEDAI-2K excluding the cutaneous items. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.010DOI Listing
March 2019
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Value of N-terminal pro-brain natriuretic peptide and aortic diameter in predicting in-hospital mortality in acute aortic dissection.

Cytokine 2019 Mar 20;119:90-94. Epub 2019 Mar 20.

Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China. Electronic address:

Objective: To determine the value of N-terminal pro-brain natriuretic peptide (NT-proBNP) and aortic diameter in predicting in-hospital mortality in acute aortic dissection (AD).

Methods: A single-center prospective study was designed in the setting of University hospital in China. 122 patients with acute AD were enrolled. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.004DOI Listing
March 2019
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Predictive value of intratumour inflammatory cytokine mRNA levels of hepatocellular carcinoma patients and activation of two distinct pathways govern IL-8 induced epithelial-mesenchymal transition in human hepatic cancer cell lines.

Cytokine 2019 Mar 20;119:81-89. Epub 2019 Mar 20.

Department of Abdominal Oncology, The Cancer Center of the Fifth Affiliated Hospital, Sun Yat-sen University, Zhuhai 519000, China. Electronic address:

Hepatocellular carcinoma (HCC) is always accompanied by persistent inflammation of liver tissues, which is considered to exert protumourigenic effects by promoting cancer growth, progression, and metastasis. However, the tumour-promoting roles and predictive value of intratumoural inflammatory cytokines remain unclear. In the present study, we used database analysis, clinical pathological studies, and in vitro biological experiments on human hepatic cancer cell lines to assess the prognostic potential of the primary tumour cytokine mRNA levels and underlying mechanisms in HCC. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.012DOI Listing
March 2019
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Exercise-induced AMPK activation and IL-6 muscle production are disturbed in adiponectin knockout mice.

Cytokine 2019 Mar 20;119:71-80. Epub 2019 Mar 20.

Department of Cell and Developmental Biology, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, Brazil. Electronic address:

Background: Adiponectin exhibits anti-inflammatory actions and is mainly expressed in adipose tissue. However, recent studies have shown that adiponectin can also be secreted by skeletal muscle fibers with autocrine and paracrine effects.

Objectives: To analyze the role of adiponectin in the metabolic and inflammatory response of skeletal muscle after acute exhaustive aerobic exercise. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.009DOI Listing
March 2019
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IL-18 induced IL-23/IL-17 expression impairs Aβ clearance in cultured THP-1 and BV2 cells.

Cytokine 2019 Mar 20;119:113-118. Epub 2019 Mar 20.

Department of Neurology, Ruijin Hospital, Shanghai Jiao Tong University, 197 Ruijin No. 2 Road, Shanghai 200025, China. Electronic address:

Recent studies have provided overwhelming evidence of the involvement of microglia-related molecular networks in the pathogenesis of Alzheimer's diseases (AD). The potential involvement of pro-inflammatory cytokines interleukin (IL)-18, IL-23 and IL-17 on amyloid (Aβ) clearance is still unclear. In this study, we addressed that there might be a net relationship among IL-18, IL-23, and IL-17 and they can affect Aβ clearance in cultured macrophage/microglia cells. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.003DOI Listing

Circulating eNampt and resistin as a proinflammatory duet predicting independently mortality in critically ill patients with sepsis: A prospective observational study.

Cytokine 2019 Mar 15;119:62-70. Epub 2019 Mar 15.

Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address:

Background: The adipocytokines eNampt and resistin are involved in the regulation of inflammation exerting pro-inflammatory actions. Our aim was to jointly investigate whether circulating eNampt and resistin, and their kinetics predict 28-day mortality of sepsis.

Methods: In a prospective study, serum eNampt and resistin were determined in 102 critically ill patients fulfilling the diagnostic criteria of SEPSIS-3, at enrollment and one week after, and in 102 healthy controls matched on age, gender and month of diagnosis. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.002DOI Listing
March 2019
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The proinflammatory effects of chronic excessive exercise.

Cytokine 2019 Mar 15;119:57-61. Epub 2019 Mar 15.

Postgraduate Program in Rehabilitation and Functional Performance, Ribeirão Preto Medical School, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil; School of Physical Education and Sport of Ribeirão Preto, University of São Paulo (USP), Ribeirão Preto, São Paulo, Brazil. Electronic address:

Chronic moderate-intensity exercise is an efficient non-pharmacological strategy to prevent and treat several diseases such as type 2 diabetes mellitus, cardiovascular and chronic obstructive pulmonary diseases, cancers, and Parkinson's disease. On the other hand, improving an athlete's performance requires completing high-intensity and volume exercise sessions. When the delicate balance between high-load exercise sessions and adequate recovery periods is disrupted, excessive training (known as overtraining) can lead to performance decline. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.016DOI Listing
March 2019
6 Reads

Cytokine profile of macrophage activation syndrome associated with Kawasaki disease.

Cytokine 2019 Mar 13;119:52-56. Epub 2019 Mar 13.

Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

The present study aimed to assess the kinetics of cytokine release and compare the accuracy of serum biomarkers for the diagnosis of macrophage activation syndrome (MAS) associated with Kawasaki disease (KD). Serum neopterin, interleukin (IL)-18, IL-6 and soluble tumour necrosis factor receptor type I (sTNFR-I) and sTNFR-II levels were determined using enzyme-linked immunosorbent assay in 78 patients with KD, including five with MAS. Results were compared to the clinical features of MAS. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.03.001DOI Listing
March 2019
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Granulocyte colony-stimulating factor-associated aortitis in the Japanese Adverse Drug Event Report database.

Cytokine 2019 Mar 12;119:47-51. Epub 2019 Mar 12.

The Institute of Medical Science, The University of Tokyo, Tokyo, Japan. Electronic address:

Background: Granulocyte colony-stimulating factor (G-CSF) is the standard-of-care therapy for chemotherapy-associated neutropenia in patients with malignancies. Recent case reports have implied that G-CSF treatment may be associated with the development of aortitis, but the precise nature of the relationship is unclear. We investigated the association between G-CSF and risk for aortitis in patients with various malignancies. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.013DOI Listing
March 2019
4 Reads

The pleiotropic association between IL-10 levels and CVD prognosis: Evidence from a meta-analysis.

Cytokine 2019 Mar 12;119:37-46. Epub 2019 Mar 12.

The First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou 510407, China; Lingnan Medical Research Center, Guangzhou University of Chinese Medicine, Guangzhou 510407, China; Key Laboratory of Chronic Heart Failure, Guangzhou University of Chinese Medicine, Guangzhou 510407, China. Electronic address:

We examined the precise association between IL-10 levels and cardiovascular disease (CVD) prognosis and explored the pleiotropic role of IL-10 in different cardiac pathologies. We performed a meta-analysis of cross-sectional and longitudinal studies investigating IL-10 levels. Meta-regression analyses were used to determine the cause of the discrepancies. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.017DOI Listing

Inhaled delivery of Interferon-lambda restricts epithelial-derived Th2 inflammation in allergic asthma.

Cytokine 2019 Mar 9;119:32-36. Epub 2019 Mar 9.

Department of Otorhinolaryngology, Seoul National University College of Medicine, Seoul, Republic of Korea; Seoul National University Hospital, Seoul, Republic of Korea. Electronic address:

The possibility has been suggested that interferon (IFN)-λs can be induced rapidly for restricting respiratory viral infection in asthmatic mice and may modulate Th2-related immune responses that underlie the pathogenesis of asthma. We sought to determine the in vivo contribution of IFN-λs on decrease of Th2 cytokines in the respiratory tract of in vivo asthma. Lungs of asthmatic mice were severely inflamed, with extensive inflammatory cell infiltration and increased goblet cell metaplasia with higher total lung resistance. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.010DOI Listing

Running interference: Interplay between Zika virus and the host interferon response.

Cytokine 2019 Mar 8;119:7-15. Epub 2019 Mar 8.

Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada; Rosalind & Morris Goodman Cancer Research Centre, McGill University, Montreal, Quebec, Canada. Electronic address:

The interferon (IFN) family of cytokines is a crucial part of the host's ability to mount an effective immune response against viral infections. In addition to establishing an antiviral state within cells, IFNs also support the optimal activation of other key immune cell types. The ability of members of the Flaviviridae family to suppress type I IFN responses has been well-described. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.009DOI Listing
March 2019
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IL-36γ regulates mediators of tissue homeostasis in epithelial cells.

Cytokine 2019 Mar 8;119:24-31. Epub 2019 Mar 8.

Oral Health Cooperative Research Centre, Melbourne Dental School, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Victoria, Australia. Electronic address:

IL-36 cytokines are critical regulators of mucosal inflammation and homeostasis. IL-36γ regulates the expression of inflammatory cytokines and antimicrobial proteins by gingival epithelial cells (e.g. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.012DOI Listing

Development of reverse-transcriptase quantitative PCR assays for detection of the cytokines IL-1β, TNF-α, and IL-10 in chelonians.

Cytokine 2019 Mar 8;119:16-23. Epub 2019 Mar 8.

Wildlife Epidemiology Laboratory, College of Veterinary Medicine at University of Illinois, Urbana, IL 61802, USA.

In response to viral pathogens, a host releases pro-inflammatory cytokines such as interleukin-1 beta (IL-1β) and tumor necrosis factor alpha (TNF-α) and anti-inflammatory cytokines such as interleukin-10 (IL-10). While several approaches exist to measure cytokine responses, evaluating gene transcription through reverse transcription quantitative polymerase chain reaction (RT-qPCR) provides a fast, reproducible, and sensitive method for quantifying this response. The objective of this study was to develop an effective and sensitive RT-qPCR assay for the quantification of red-eared slider (Trachemys scripta elegans) and eastern box turtle (Terrapene carolina carolina) cytokines: IL-1β, TNFα, IL-10 and the reference gene β-actin. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666193005
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http://dx.doi.org/10.1016/j.cyto.2019.02.011DOI Listing
March 2019
3 Reads

Identification of the IL-33 protein segment that controls subcellular localization, extracellular secretion, and functional maturation.

Cytokine 2019 Mar 8;119:1-6. Epub 2019 Mar 8.

Department of Medicine, University of Maryland School of Medicine, 10 S. Pine St., MSTF 8-34, Baltimore, MD 21201, United States; Research Service, Baltimore VA Medical Center, 10 N. Greene St, Baltimore, MD 21201, United States. Electronic address:

Proteolytic activation of the IL-33 precursor, full-length interleukin-33 (FLIL33), at multiple sites within the sensor domain (aa 95-109) yields several functionally mature (MIL33) forms. Unlike nuclear FLIL33, intracellular MIL33 occurs in the cytoplasm, is secreted from source cells, and exerts biological effects by activating the ST2 receptor on target cells. Previous studies and our findings in this report indicated that IL-33 forms that are substantially longer than those produced by cleavage within the sensor domain are biologically indistinguishable from classical MIL33. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.015DOI Listing

Serum multiple cytokines for the prediction of spontaneous preterm birth in asymptomatic women: A nested case-control study.

Cytokine 2019 Mar 1;117:91-97. Epub 2019 Mar 1.

Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning 530021, Guangxi, China; Institute of Urology and Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China. Electronic address:

Background: Current biomarkers such as fetal fibronectin and cervical length are accurate predictors of spontaneous preterm birth (sPTB) in women with clinically suspected preterm risk; however, these are not effective for predicting the risk of sPTB in asymptomatic women. Therefore, we performed this study with the objective of determining whether the combinations of specific serum cytokines could accurately predict the sPTB risk in asymptomatic women.

Methods: We conducted a nested case-control study with 129 incident sPTB cases and 258 individually matched controls who participated in an ongoing birth cohort study. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.007DOI Listing
March 2019
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The role of IL-36γ and its regulation in eosinophilic inflammation in allergic rhinitis.

Cytokine 2019 Mar 1;117:84-90. Epub 2019 Mar 1.

Department of Otolaryngology, First Affiliated Hospital to Harbin Medical University, Harbin, China. Electronic address:

Background: Allergic rhinitis (AR) is characterized by eosinophilic inflammation. However, the function and regulation of eosinophils in AR are largely unknown. This study aimed to explore the expression and role of interleukin-36 (IL-36) cytokines in AR. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.008DOI Listing
March 2019
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Polymorphisms of IL-23R predict survival of gastric cancer patients in a Chinese population.

Cytokine 2019 Mar 1;117:79-83. Epub 2019 Mar 1.

General Clinical Research Center, Nanjing First Hospital, Nanjing Medical University, Nanjing, China; Helicobacter pylori Research Key Laboratory, Nanjing Medical University, Nanjing, China; Jiangsu Collaborative Innovation Center on Cancer Personalized Medicine, Nanjing Medical University, Nanjing, China. Electronic address:

IL-17/IL-23 pathway has been hypothesized to play a role in occurrence and progression of gastric cancer. To investigate the susceptibility and prognostic value of polymorphisms in genes in the IL-17/IL-23 pathway to gastric cancer, we performed a case-control study combined a retrospective study in a Chinese population. The Sequenom's MassARRAY genotyping platform was used to genotype the polymorphisms, and infection of Helicobacter pylori (H. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.014DOI Listing
March 2019
7 Reads
2.664 Impact Factor

Circulating levels of CXCL11 and CXCL12 are biomarkers of cirrhosis in patients with chronic hepatitis C infection.

Cytokine 2019 Feb 28;117:72-78. Epub 2019 Feb 28.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail), UMR_S 1085, F-35000 Rennes, France. Electronic address:

Background & Aims: The chemokines CXCL10 (interferon ϒ-inducible protein 10 [IP-10]), CXCL11 (Human interferon inducible T cell alpha chemokine [I-TAC]), and CXCL12 (stromal cell derived factor 1 [SDF-1]) contribute to cell recruitment, migration, activation, and homing in liver diseases and their serum levels have been shown to be associated with the degree of liver inflammation or fibrosis in various etiologies. However, the data may be contradictory or insufficient, particularly for CXCL12, in the field of chronic HCV infection. Here, we aimed to provide evidence for these chemokines as biomarkers for chronic HCV infection. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.006DOI Listing
February 2019
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Association between chronic obstructive pulmonary disease and interleukins gene variants: A systematic review and meta-analysis.

Cytokine 2019 Feb 28;117:65-71. Epub 2019 Feb 28.

Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.

Interleukins are cytokines involved in systemic inflammation and immune system regulation. Many studies have investigated the association between common genetic variations in interleukin-coding genes and COPD susceptibility. In this study, a systematic review and meta-analysis was performed to evaluate the association between interleukin gene variations and COPD pathogenesis. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.003DOI Listing
February 2019
2 Reads
2.664 Impact Factor

C-reactive protein for predicting cardiovascular and all-cause mortality in type 2 diabetic patients: A meta-analysis.

Cytokine 2019 Feb 28;117:59-64. Epub 2019 Feb 28.

Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China. Electronic address:

Aims: There is interest in using blood C-reactive protein (CRP) to predict adverse prognosis outcomes patients with type 2 diabetes. This meta-analysis aimed to investigate the association between elevated baseline CRP level and unfavorable outcomes in type 2 diabetes patients.

Materials/methods: PubMed and Embase databases were systematically searched for studies on the association of elevated baseline CRP level with cardiovascular mortality and all-cause mortality from their inception to July 2018. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.005DOI Listing
February 2019

The anti-fibrotic role of mast cells in the liver is mediated by HLA-G and interaction with hepatic stellate cells.

Cytokine 2019 Feb 27;117:50-58. Epub 2019 Feb 27.

Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en santé, environnement et travail) - UMR_S 1085, F-35000 Rennes, France.

Background & Aims: We have reported a significant association between HLA-G expression or the number of hepatic mast cells and liver fibrosis. Here, we investigated the role of HLA-G and mast cells in liver fibrosis, focusing, in particular, on interactions between human mast and stellate cells.

Methods: Human mast cells (HMC cell line, CD34-derived mast cells, or tissue-derived mast cells) were co-cultured with purified human hepatic stellate cells (HSCs), and collagen I production by HSCs was evaluated. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.002DOI Listing
February 2019

Adipokine expression in systemic sclerosis lung and gastrointestinal organ involvement.

Cytokine 2019 Feb 19;117:41-49. Epub 2019 Feb 19.

Dept of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University, Giessen, Germany.

Objectives: The immunomodulatory properties of adipokines have previously been reported in autoimmune disorders. Less is known about the role of adipokines in systemic sclerosis (SSc). Lung and gastrointestinal tract are frequently involved in SSc; therefore, these organs were analyzed for adipokine expression as well as pulmonary samples of patients suffering from idiopathic pulmonary fibrosis (IPF) as comparison. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183042
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http://dx.doi.org/10.1016/j.cyto.2018.11.013DOI Listing
February 2019
7 Reads
2.664 Impact Factor

The role of cytokines in the regulation of NK cells in the tumor environment.

Cytokine 2019 Feb 18;117:30-40. Epub 2019 Feb 18.

Faculty of Medical Sciences, University of Kragujevac, P.BOX 124, 34000 Kragujevac, Serbia. Electronic address:

Natural killer (NK) cells are innate lymphoid cells that are important effectors in the first line of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms and by production of immunoregulatory cytokines. Recent evidence has shown that NK cells also display memory, similar to the cells of the adaptive immune system. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.001DOI Listing
February 2019
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Tailoring the immune response to wheat gliadin by enzymatic transamidation.

Cytokine 2019 Feb 18;117:23-29. Epub 2019 Feb 18.

Institute of Food Sciences, CNR, 83100 Avellino, Italy. Electronic address:

Enzymatic transamidation of wheat gliadin by microbial transglutaminase inhibits IFN-γ secretion by intestinal T cell lines from celiac disease (CD) patients. Here, we analysed its effects on intestinal biopsies from CD patients and studied the underlying mechanisms in HLA-DQ8 transgenic (tg) mice, a model of T-cell mediated gluten sensitivity. In vitro challenge with a soluble form of transamidated gliadin (spf) upregulated IL-10 transcript levels in human biopsy samples. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.004DOI Listing
February 2019
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Growth and differentiation factor 15 is a biomarker for low back pain-associated disability.

Cytokine 2019 Feb 15;117:8-14. Epub 2019 Feb 15.

Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, 6905126 Tel-Aviv, Israel; Lilian and Marcel Pollak Chair of Biological Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, 6905126 Tel-Aviv, Israel. Electronic address:

The development of low back pain (LBP) is often associated with obesity and sarcopenia. However, the mechanisms of this association remain unclear. To clarify this, we measured circulating levels of a selected panel of soluble factors, presumably involved in obesity and sarcopenia pathogenesis, and correlated them with several LBP-related characteristics, taking into account body composition and other relevant covariates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666193003
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http://dx.doi.org/10.1016/j.cyto.2019.01.011DOI Listing
February 2019
10 Reads

The senescence-associated secretory phenotype and its regulation.

Cytokine 2019 Feb 15;117:15-22. Epub 2019 Feb 15.

Department of Biochemistry and Molecular Medicine, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7, Canada; CRCHUM, 900 Saint-Denis - Room R10.432, Montréal, QC H2X 0A9, Canada. Electronic address:

The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context. The SASP reinforces the senescent cell cycle arrest, stimulates the immune-mediated clearance of potentially tumorigenic cells, limits fibrosis and promotes wound healing and tissue regeneration. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.013DOI Listing
February 2019

Association between high levels of inflammatory markers and cognitive outcomes at 4 years of age: The Rhea mother-child cohort study, Crete, Greece.

Cytokine 2019 Feb 14;117:1-7. Epub 2019 Feb 14.

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.

There is growing evidence associating inflammatory markers in complex, higher order neurological functions, such as cognition and memory. We examined whether high levels of various inflammatory markers are associated with cognitive outcomes at 4 years of age in a mother-child cohort in Crete, Greece (Rhea study). We included 642 children in this cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.010DOI Listing
February 2019
2 Reads