5,311 results match your criteria Cytokine [Journal]


Adipokine expression in systemic sclerosis lung and gastrointestinal organ involvement.

Cytokine 2019 Feb 19;117:41-49. Epub 2019 Feb 19.

Dept of Rheumatology and Clinical Immunology, Campus Kerckhoff, Justus-Liebig-University, Giessen, Germany.

Objectives: The immunomodulatory properties of adipokines have previously been reported in autoimmune disorders. Less is known about the role of adipokines in systemic sclerosis (SSc). Lung and gastrointestinal tract are frequently involved in SSc; therefore, these organs were analyzed for adipokine expression as well as pulmonary samples of patients suffering from idiopathic pulmonary fibrosis (IPF) as comparison. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183042
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http://dx.doi.org/10.1016/j.cyto.2018.11.013DOI Listing
February 2019
1 Read

The role of cytokines in the regulation of NK cells in the tumor environment.

Cytokine 2019 Feb 18;117:30-40. Epub 2019 Feb 18.

Faculty of Medical Sciences, University of Kragujevac, P.BOX 124, 34000 Kragujevac, Serbia. Electronic address:

Natural killer (NK) cells are innate lymphoid cells that are important effectors in the first line of defense toward transformed cells. This is mediated both by direct cytotoxic mechanisms and by production of immunoregulatory cytokines. Recent evidence has shown that NK cells also display memory, similar to the cells of the adaptive immune system. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.001DOI Listing
February 2019

Tailoring the immune response to wheat gliadin by enzymatic transamidation.

Cytokine 2019 Feb 18;117:23-29. Epub 2019 Feb 18.

Institute of Food Sciences, CNR, 83100 Avellino, Italy. Electronic address:

Enzymatic transamidation of wheat gliadin by microbial transglutaminase inhibits IFN-γ secretion by intestinal T cell lines from celiac disease (CD) patients. Here, we analysed its effects on intestinal biopsies from CD patients and studied the underlying mechanisms in HLA-DQ8 transgenic (tg) mice, a model of T-cell mediated gluten sensitivity. In vitro challenge with a soluble form of transamidated gliadin (spf) upregulated IL-10 transcript levels in human biopsy samples. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.02.004DOI Listing
February 2019

Growth and differentiation factor 15 is a biomarker for low back pain-associated disability.

Cytokine 2019 Feb 15;117:8-14. Epub 2019 Feb 15.

Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, 6905126 Tel-Aviv, Israel; Lilian and Marcel Pollak Chair of Biological Anthropology, Sackler Faculty of Medicine, Tel-Aviv University, 6905126 Tel-Aviv, Israel. Electronic address:

The development of low back pain (LBP) is often associated with obesity and sarcopenia. However, the mechanisms of this association remain unclear. To clarify this, we measured circulating levels of a selected panel of soluble factors, presumably involved in obesity and sarcopenia pathogenesis, and correlated them with several LBP-related characteristics, taking into account body composition and other relevant covariates. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666193003
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http://dx.doi.org/10.1016/j.cyto.2019.01.011DOI Listing
February 2019
1 Read

The senescence-associated secretory phenotype and its regulation.

Cytokine 2019 Feb 15;117:15-22. Epub 2019 Feb 15.

Department of Biochemistry and Molecular Medicine, Université de Montréal, C.P. 6128, Succ. Centre-Ville, Montréal, Québec H3C 3J7, Canada; CRCHUM, 900 Saint-Denis - Room R10.432, Montréal, QC H2X 0A9, Canada. Electronic address:

The senescence-associated secretory phenotype (SASP) defines the ability of senescent cells to express and secrete a variety of extracellular modulators that includes cytokines, chemokines, proteases, growth factors and bioactive lipids. The role of the SASP depends on the context. The SASP reinforces the senescent cell cycle arrest, stimulates the immune-mediated clearance of potentially tumorigenic cells, limits fibrosis and promotes wound healing and tissue regeneration. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.013DOI Listing
February 2019

Association between high levels of inflammatory markers and cognitive outcomes at 4 years of age: The Rhea mother-child cohort study, Crete, Greece.

Cytokine 2019 Feb 14;117:1-7. Epub 2019 Feb 14.

Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA.

There is growing evidence associating inflammatory markers in complex, higher order neurological functions, such as cognition and memory. We examined whether high levels of various inflammatory markers are associated with cognitive outcomes at 4 years of age in a mother-child cohort in Crete, Greece (Rhea study). We included 642 children in this cross-sectional study. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.010DOI Listing
February 2019

Interleukin-17: Friend or foe in organ fibrosis.

Cytokine 2019 Feb 13. Epub 2019 Feb 13.

Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA. Electronic address:

Fibrosis affects all vital organs accounting for a staggering 45% of deaths worldwide and no effective therapies are currently available. Unresolved inflammation triggers downstream signaling events that lead to organ fibrosis. In recent years, proinflammatory cytokine Interleukin-17 (IL-17) has been implicated in several chronic inflammatory diseases that often culminate in organ damage followed by impaired wound healing and fibrosis. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.003DOI Listing
February 2019

Atherogenic cytokines and chemokines in chronic hepatitis C are not associated with the presence of cardiovascular diseases.

Cytokine 2019 Feb 13;115:24-31. Epub 2019 Feb 13.

Faculdade de Farmácia, Laboratório de Pesquisa em Imunologia, Universidade Federal da Bahia, Brazil. Electronic address:

There appears to be an associative link between chronic hepatitis C (CHC) and cardiovascular diseases (CVDs). However, the exact nature of the relationship between CHC and CVDs has not been elucidated. We investigated the presence of CVDs and the clinical and laboratory alterations associated with these diseases in CHC patients. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183048
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http://dx.doi.org/10.1016/j.cyto.2018.12.005DOI Listing
February 2019
4 Reads

The tertiary structure of γc cytokines dictates receptor sharing.

Authors:
Pedro A Reche

Cytokine 2019 Apr 2;116:161-168. Epub 2019 Feb 2.

Laboratory of Immunomedicine, School of Medicine, Department of Immunology & O2, Universidad Complutense de Madrid, Ave Complutense S/N, Madrid 28040, Spain. Electronic address:

The γc family of cytokines comprising interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15 and IL-2 is an important group of 4-helix bundle cytokines that signals through receptors incorporating the common gamma chain (γc). These cytokines are involved in lymphocyte biology and their specific functions are contingent on binding to cognate receptor chains. Here, we examined the structural relationships between γc cytokines, aiming to understand the basis for receptor chain usage and sharing. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.007DOI Listing

Differential expression patterns of Toll Like Receptors and Interleukin-37 between calcific aortic and mitral valve cusps in humans.

Cytokine 2019 Apr 1;116:150-160. Epub 2019 Feb 1.

Centre for Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, Athens, Greece.

Background: Significant differences are mentioned in the progress of calcification between aortic and mitral valve. Evidence of inflammation in calcific aortic and mitral valve disease suggests that pathways of Toll Like Receptors (TLR) and Interleukin (IL)-37 expression may contribute to this process. We sought to investigate the role of TLR-mediated inflammatory response and IL-37 pathway expression on aortic and mitral valve calcification. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.009DOI Listing

Adiponectin deficiency has no effect in murine autoimmune myocarditis.

Cytokine 2019 Apr 1;116:139-149. Epub 2019 Feb 1.

Department of Cardiology, University of Heidelberg, Heidelberg, Germany. Electronic address:

Background: Adiponectin is a hormone that together with its receptors modulates a number of metabolic processes including gluconeogenesis and lipid catabolism. It belongs to the C1QTNF (complement C1q tumor necrosis factor-related protein) family, which has a variety of members with high amino acid sequence homology and overlapping functions. Concentration of adiponectin in blood is inversely correlated with body fat percentage and cardiac risk factors like blood pressure and CRP (C-reactive protein) level. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.022DOI Listing
April 2019
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Intercellular adhesion molecule-1 (ICAM-1) associates with 24-hour ambulatory blood pressure variability in type 2 diabetes and controls.

Cytokine 2019 Apr 1;116:134-138. Epub 2019 Feb 1.

Iuliu Hatieganu University of Medicine and Pharmacy, Faculty of Medicine, Department of Diabetes and Nutrition, Cluj-Napoca, Romania.

Background And Aim: Endothelial dysfunction is a common feature in hypertension and type 2 diabetes. Whether blood pressure (BP) variability is influencing serum intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) remains to be clarified. We aimed to assess the association between the circulating adhesion molecules and ambulatory blood pressure variability in patients with type 2 diabetes and controls. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.006DOI Listing

The "Yin-Yang" of cytokines in cancer.

Cytokine 2019 Jan 31. Epub 2019 Jan 31.

Department of Microbiology and Immunology, Greenebaum NCI-Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.12.013DOI Listing
January 2019

Immunological aspects of autoimmune thyroid disease - Complex interplay between cells and cytokines.

Cytokine 2019 Apr 1;116:128-133. Epub 2019 Feb 1.

Department of Pathology and Experimental Rheumatology, Medical University of Gdansk, Poland. Electronic address:

Autoimmune thyroid disease (ATD) is a chronic autoimmune thyroiditis with a complex pathogenesis including environmental factors, genetic background and immune system actions. Despite the large-scale research and discovery of new subpopulations of lymphocytes, cytokines, chemokines and their functions in the human body, the ethiology of ATD in many aspects remains a mystery. This article tries to summarize mostly the immunological aspects of this disease, including the roles of different cells types (dendritic cells, B cells, CD4 and CD8 T cells, NK cells and regulatory T cells) and of different cytokines (secreted by Th1/Th2/Th17/Th22 lymphocyte subpopulations and other, including the IL-23 and CXCL10). Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.003DOI Listing
April 2019
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Comprehensive biology of antipyretic pathways.

Cytokine 2019 Apr 1;116:120-127. Epub 2019 Feb 1.

Toxicology Division, Biomedical Technology Wing, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Poojapura, Trivandrum 695 012, Kerala, India. Electronic address:

Pyrogens, the fever inducing substances accidently enter into a human body through contamination from medical or pharmaceutical products may create mild to severe complications including septicaemia and shocking syndromes. To avoid such drastic situations all the pharmaceuticals and medical devices are analysed for presence of pyrogens prior to their release into market. The entry of exogenous pyrogens like bacterial endotoxins induces the release of endogenous pyrogens or inflammatory cytokines that activate immune system to defend against these pathogens. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.008DOI Listing

Effect of betamethasone, indomethacin and fenoterol on neonatal and maternal mononuclear cells stimulated with Escherichia coli.

Cytokine 2019 Apr 28;116:97-105. Epub 2019 Jan 28.

Clinic of Gynecology and Obstetrics St. Hedwig, University of Regensburg, Regensburg, Germany. Electronic address:

Despite considerable progress in the field of perinatal care, infectious diseases, especially when caused by gram negative bacteria, remain a major reason for neonatal morbidity and mortality. Notably infants born prematurely and those with very low birth weight are at risk due to their immature and deficient immune system and their prolonged hospitalization which promotes nosocomial infections. In case of impending preterm birth, betamethasone is given to induce lung maturation and tocolytic agents like indomethacin or fenoterol are administered to suppress premature labor. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.017DOI Listing
April 2019
1 Read

Inflammatory expression profile in peripheral blood mononuclear cells from patients with Nasu-Hakola Disease.

Cytokine 2019 Apr 25;116:115-119. Epub 2019 Jan 25.

University of Milan, Centro Dino Ferrari, Milan, Italy; Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy.

Homozygous mutations in Triggering Receptor Expressed on Myeloid cells 2 gene (TREM2) are one of the major causes of Nasu Hakola Disease (NHD). We analysed Peripheral Blood Mononuclear Cells (PBMC) profile of 164 inflammatory factors in patients with NHD carrying the TREM2 Q33X mutation as compared with heterozygous and wild type individuals. Several molecules related to bone formation and angiogenesis were altered in NHD compared to non-carriers: Bone Morphogenetic Protein (BMP)-1 mRNA levels were significantly increased in PBMC (2. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.024DOI Listing

Palmitate-induced IL6 expression ameliorated by chicoric acid through AMPK and SIRT1-mediated pathway in the PBMCs of newly diagnosed type 2 diabetes patients and healthy subjects.

Cytokine 2019 Apr 25;116:106-114. Epub 2019 Jan 25.

Department of Internal Medicine, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran.

Inhibition of inflammation is one of the possible therapeutic approaches for Insulin resistance (IR) during type 2 diabetes mellitus (T2DM). In the current study we investigated the effects of palmitate and chicoric acid (CA) on inflammation in peripheral blood mononuclear cells (PBMCs) of newly diagnosed T2DM patients and healthy subjects and explored the mechanism by which palmitate and CA influence inflammation. 20 newly diagnosed T2DM patients and 20 healthy subjects were recruited in our study. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183048
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http://dx.doi.org/10.1016/j.cyto.2018.12.012DOI Listing
April 2019
3 Reads

Suitability of serum cytokine profiling for early diagnosis of implant-associated infections after orthopaedic surgery: A preliminary prospective study.

Cytokine 2019 Apr 24;116:88-96. Epub 2019 Jan 24.

Comparative Medicine, Center for Molecular Medicine, University of Cologne, Cologne, Germany; Cologne Center for Musculoskeletal Biomechanics, University of Cologne, Cologne, Germany. Electronic address:

The C-reactive protein (CRP) is still the conventional marker used to diagnose implant-associated infections (IAI) after orthopaedic surgery. However, the CRP level can lead to misdiagnosis since it is up-regulated not only during bacterial infection. In this prospective study, we evaluated the serum cytokine profile before (pre-OP) and after orthopaedic surgery (post-OP) as well as after confirmation of a developed infection (COI) to identify candidate biomarkers for diagnosis of IAI. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.016DOI Listing
April 2019
1 Read

Identification of an IKBKE inhibitor with antitumor activity in cancer cells overexpressing IKBKE.

Cytokine 2019 Apr 24;116:78-87. Epub 2019 Jan 24.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. Electronic address:

Background: The serine/threonine kinase IKBKE is frequently overexpressed or activated in a variety of human cancers. Ectopic expression of IKBKE induces malignant transformation, cell migration, invasion and chemoresistance. Thus, IKBKE is an attractive target for anti-cancer drug development. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.005DOI Listing
April 2019
3 Reads

SQSTM1/p62 regulates the production of IL-8 and MCP-1 in IL-1β-stimulated human retinal pigment epithelial cells.

Cytokine 2019 Apr 24;116:70-77. Epub 2019 Jan 24.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, P.O. Box 1627, FI-70211 Kuopio, Finland.

Age-related macular degeneration (AMD) is a complex eye disease in which decline in autophagy leads to the accumulation of sequestosome 1/p62 (SQSTM1/p62)-labeled waste material inside the retinal pigment epithelial (RPE) cells, and the condition results in activation of the inflammasome signaling and IL-1β secretion. Here, we have studied the role of SQSTM1/p62 in the production of IL-6, IL-8, and MCP-1 in the presence or absence of IL-1β. SQSTM1/p62 was either overexpressed or silenced in ARPE-19 cells, which were then exposed to IL-1β. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.015DOI Listing
April 2019
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Overexpression of CCN1 in Het1A cells attenuates bile-induced esophageal metaplasia through suppressing non-canonical NFκB activation.

Cytokine 2019 Apr 24;116:61-69. Epub 2019 Jan 24.

Inner Mongolia Institute of Digestive Diseases, The Second Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, 30 Hudemulin Rd, Baotou 014030, China; Laboratory of Gastrointestinal Injury and Cancer, VA Long Beach Healthcare System, Long Beach, CA 90822, USA; College of Medicine, University of California, Irvine, CA 92697, USA. Electronic address:

GERD is the most common gastrointestinal diagnosis given during office visit. People who suffer from a long history of GERD eventually develop Barrett's esophagus, a premalignant intestinal metaplasia due to NFκB activation. Previous studies focused on the contribution of TNF-triggered canonical NFκB pathway to this event. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.020DOI Listing
April 2019
1 Read

Anti-inflammatory property of quercetin through downregulation of ICAM-1 and MMP-9 in TNF-α-activated retinal pigment epithelial cells.

Cytokine 2019 Apr 24;116:48-60. Epub 2019 Jan 24.

Graduate Institute of Health Industry Technology, Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan; Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung, Taiwan; Department of Ophthalmology, Chang Gung Memorial Hospital, Linkou, Taiwan. Electronic address:

Quercetin is a flavonoid polyphenolic compound present in fruits and vegetables that has proven anti-inflammatory activity. The goal of the present investigation was to investigate the effects of quercetin on tumor necrosis factor-α (TNF-α)-induced inflammatory responses via the expression of ICAM-1 and MMP-9 in human retinal pigment epithelial cells (ARPE-19 cells). Real-time PCR, gelatin zymography, and Western blot analysis showed that TNF-α induced the expression of ICAM-1 and MMP-9 protein and mRNA in a time-dependent manner. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.001DOI Listing
April 2019
2 Reads
2.664 Impact Factor

G-CSF administration favours SDF-1 release and activation of neutrophils and monocytes in recipients of autologous peripheral blood progenitor cells.

Cytokine 2019 Apr 24;116:38-47. Epub 2019 Jan 24.

Laboratory of Clinical Immunogenetics and Pharmacogenetics, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Weigla 12, 53-114 Wroclaw, Poland; Department of Internal Diseases, Occupational Medicine, Hypertension and Clinical Oncology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

G-CSF is a growth factor widely used to mobilise CD34+ progenitor cells for clinical applications. The present study aimed to assess expression of G-CSF receptor (CSF3R) on neutrophils and monocytes, as well as SDF-1 and G-CSF serum levels in relation to efficacy of G-CSF-induced mobilisation for autologous transplantation. For this purpose, 105 patients with haematological disorders and 46 healthy controls were investigated. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.011DOI Listing
April 2019
7 Reads

Type I interferon dysregulation in Systemic Sclerosis.

Cytokine 2019 Jan 23. Epub 2019 Jan 23.

The University of Texas Health Science Center in Houston, Division of Rheumatology, 6431 Fannin, MSB 5.262, Houston, TX 77030, United States. Electronic address:

Systemic Sclerosis (Scleroderma, SSc) is a multifaceted disease characterized by autoimmunity, vasculopathy, and fibrosis affecting the skin and internal organs. Despite advances in the understanding and treatment of SSc in recent years, SSc continues to cause reduced quality of life and premature mortality. Type I interferons (IFNs), a family of cytokines with essential roles in the immune response to microbial infection, play a pathogenic role in certain autoimmune diseases (reviewed elsewhere in this edition). Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.018DOI Listing
January 2019
2 Reads

Novel genetic associations with interferon in systemic lupus erythematosus identified by replication and fine-mapping of trait-stratified genome-wide screen.

Cytokine 2019 Jan 23. Epub 2019 Jan 23.

Colton Center for Autoimmunity, New York University School of Medicine, New York, NY, USA. Electronic address:

Background/purpose: High serum interferon alpha (IFN-α) is an important heritable phenotype in systemic lupus erythematosus (SLE) which is involved in primary disease pathogenesis. High vs. low levels of IFN-α are associated with disease severity and account for some of the biological heterogeneity between SLE patients. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.014DOI Listing
January 2019
2 Reads
2.664 Impact Factor

IL-17 and colorectal cancer: From carcinogenesis to treatment.

Cytokine 2019 Apr 23;116:7-12. Epub 2019 Jan 23.

Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran; Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran; Cancer Immunology Project (CIP), Universal Scientific Education and Research Network (USERN), Sheffield, UK. Electronic address:

Colorectal cancer (CRC) is one of the most common types of cancer in the world. Several factors contribute to the development of this cancer. Tumor formation in colon triggers immune responses such as immune cells proliferation, phenotype alteration, cytokine synthesis and release, which lead to IL-17 producing T cells, the differentiated CD4+ T cells i. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.021DOI Listing
April 2019
5 Reads
2.664 Impact Factor

One-year follow-up of the immune profile in serum and selected sites of generalized and localized aggressive periodontitis.

Cytokine 2019 Apr 23;116:27-37. Epub 2019 Jan 23.

Department of Stomatology, Dental School, University of São Paulo, São Paulo, SP, Brazil. Electronic address:

Background: The local and systemic immunological profiles of important inflammatory mediators in the localized (LAgP) and generalized (GAgP) forms of aggressive periodontitis are still unknown, as well as the effect of periodontal therapy on these parameters. The aim of this prospective study was to evaluate clinical and immune responses of patients with AgP undergoing nonsurgical treatment.

Material And Methods: Eighteen patients with GAgP, 10 with LAgP and 10 healthy participants were included in this study. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.019DOI Listing
April 2019
2 Reads

Th17-associated cytokines multiplex testing indicates the potential of macrophage inflammatory protein-3 alpha in the diagnosis of biliary atresia.

Cytokine 2019 Apr 23;116:21-26. Epub 2019 Jan 23.

Department of Medical Ultrasonics, Institute of Diagnostic and Interventional Ultrasound, The First Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Guangzhou 510080, PR China. Electronic address:

Background & Aims: Biliary atresia (BA) is a neonatal obliterative cholangiopathy with high prevalence in south China. Accurate identification of BA among infants with obstructive jaundice is still difficult by noninvasive diagnostic tools. Th17 cells have been reported closely related with the development of BA, which suggest that Th17-associated cytokines were potential biomarkers for the diagnosis of BA patients. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.002DOI Listing
April 2019
1 Read
2.664 Impact Factor

Pro-inflammatory S100A11 is elevated in inflammatory myopathies and reflects disease activity and extramuscular manifestations in myositis.

Cytokine 2019 Apr 23;116:13-20. Epub 2019 Jan 23.

Institute of Rheumatology and Department of Rheumatology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. Electronic address:

Background: S100A11 (calgizzarin), a member of the S100 family, is associated with oncogenesis, inflammation and myocardial damage. Our aim was to analyse S100A11 in idiopathic inflammatory myopathies (IIMs) and its association with disease activity features and cancer development.

Methods: S100A11 in muscle was determined by immunohistochemistry in polymyositis (PM), dermatomyositis (DM), myasthenia gravis (MG) and in subjects without autoimmune inflammatory disease (HC). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666193001
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http://dx.doi.org/10.1016/j.cyto.2018.12.023DOI Listing
April 2019
2 Reads

Comparison of interleukin-6, interleukin-10, procalcitonin and C-reactive protein in identifying high-risk febrile illness in pediatric cancer patients: A prospective observational study.

Cytokine 2019 Apr 23;116:1-6. Epub 2019 Jan 23.

Division of Hematology-oncology, Children's Hospital of Zhejiang University School of Medicine, Hangzhou, PR China. Electronic address:

The aim of this study is to systematically compare the performance of C-reactive protein (CRP), procalcitonin (PCT) and serum cytokines in identifying pediatric cancer patients with high-risk infection. A prospective observational study was performed from January 2014 through December 2016. Consecutive pediatric cancer patients who experienced febrile illness during hospitalization were enrolled. Read More

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http://dx.doi.org/10.1016/j.cyto.2019.01.004DOI Listing
April 2019
2 Reads

Tea polyphenols protect gingival keratinocytes against TNF-α-induced tight junction barrier dysfunction and attenuate the inflammatory response of monocytes/macrophages.

Cytokine 2019 Jan 10;115:64-75. Epub 2019 Jan 10.

Oral Ecology Research Group, Faculty of Dentistry, Université Laval, Quebec City, QC, Canada. Electronic address:

Tea, an aromatic beverage prepared with the leaves of the Camellia sinensis plant, is well known to contain bioactive polyphenols. Green tea contains mainly catechins such as epigallocatechin-3-gallate (EGCG), while black tea is characterized by the presence of theaflavins. TNF-α, which is a pro-inflammatory cytokine that activates the endogenous inflammatory cascade, plays a key role in periodontitis. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183048
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http://dx.doi.org/10.1016/j.cyto.2018.12.009DOI Listing
January 2019
6 Reads

Synergetic roles of TGF-β signaling in tissue engineering.

Cytokine 2019 Jan 8;115:60-63. Epub 2019 Jan 8.

Deparment of Pharmacology, College of Medicine, University of Arizona, USA; Department of Chemistry and Biochemistry, University of Arizona, USA; The University of Arizona Cancer Center, USA. Electronic address:

Recent advances in tissue engineering highlight biomaterial designs with context-specific growth factors, cytokines and various small molecules to better mimic the natural extracellular matrix (ECM) microenvironments. These efforts have led to direct improvements in cell-cell and cell-ECM interactions while mitigating undesirable cellular and immunogenic responses. In this short review, we focus on the crucial roles and regulation of transforming growth factor β (TGF-β) signaling in biomaterial applications during tissue repair and regeneration. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S10434666183048
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http://dx.doi.org/10.1016/j.cyto.2018.12.010DOI Listing
January 2019
3 Reads

Gene polymorphisms in the interleukins gene and the risk of acute pancreatitis: A meta-analysis.

Cytokine 2019 Jan 8;115:50-59. Epub 2019 Jan 8.

Pancreas Center, First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, People's Republic of China; Pancreas Institute, Nanjing Medical University, Nanjing 210029, Jiangsu Province, People's Republic of China. Electronic address:

Single nucleotide polymorphisms (SNPs) within the interleukins (IL) gene may affect the risk of acute pancreatitis. Many epidemiological studies have reported an association between the IL gene and acute pancreatitis risk, but the results remain inconsistent. Given the controversial available data, we carried out a meta-analysis to systematically evaluate and clarify the association between IL gene polymorphisms and AP. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.003DOI Listing
January 2019
2 Reads

Muscular-based and patient-reported outcomes differentially associate with circulating superoxide dismutases and cytokines in knee osteoarthritis.

Cytokine 2019 Jan 8;115:45-49. Epub 2019 Jan 8.

The Orthopedic Specialty Hospital, Murray, UT 84107, USA; The Orthopedic Specialty Clinic, Murray, UT 84107, USA.

Muscular (i.e., quadriceps) weakness contributes to disease progression and precedes the appearance of patient-reported symptoms, such as pain and perceived physical dysfunction, in knee osteoarthritis (OA). Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.034DOI Listing
January 2019
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Salivary levels of MPO, MMP-8 and TIMP-1 are associated with gingival inflammation response patterns during experimental gingivitis.

Cytokine 2019 Jan 6. Epub 2019 Jan 6.

Section of Periodontology, Department of Dentistry and Oral Health, Aarhus University, Aarhus, Denmark.

Aim: This study aimed to investigate the association between salivary levels of myeloperoxidase (MPO), neutrophil elastase (NE), soluble urokinase-type plasminogen activator receptor (suPAR), matrix metalloproteinase (MMP)-8 and tissue inhibitor of matrix metalloproteinases (TIMP)-1 and gingival inflammation development during an experimental gingivitis study.

Methods: A three-week experimental gingivitis study was conducted. Clinical recordings of dental plaque biofilm (Modified Quigley Hein Plaque Index, TQHPI) and gingival inflammation (Modified Gingival Index, MGI) were made at specific time points for each of the 42 participants. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.002DOI Listing
January 2019
5 Reads

CCL22 is a biomarker of cartilage injury and plays a functional role in chondrocyte apoptosis.

Cytokine 2019 Jan 7;115:32-44. Epub 2019 Jan 7.

McCaig Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada; Biomedical Engineering Graduate Program, University of Calgary, Calgary, Alberta, Canada. Electronic address:

Background: Osteoarthritis (OA) is one of the leading causes of disability worldwide. Previous history of knee injury is a significant risk factor for OA. It has been established that low-level chronic inflammation plays a pivotal role in the onset and pathogenesis of OA. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.030DOI Listing
January 2019
7 Reads

Serum level of macrophage migration inhibitory factor predicts severity and prognosis in patients with ischemic stroke.

Cytokine 2019 Jan 4;115:8-12. Epub 2019 Jan 4.

Department of Neurology II, The First Affiliated Hospital of Xinxiang Medical University, Xinxiang, China; Henan Key Laboratory of Neural Regeneration, Xinxiang, China. Electronic address:

Objective: To evaluate whether the macrophage migration inhibitory factor (MIF) level in serum of ischemic stroke patients was associated with their clinical severity and early outcome.

Methods: During February 2017-March 2018, consecutive patients admitted to our hospital because of first-ever ischemic stroke were identified. The prognostic value of MIF was set for predicting the outcome of these patients at discharge. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.029DOI Listing
January 2019
2 Reads

Decoding the enigma of antiviral crisis: Does one target molecule regulate all?

Cytokine 2019 Jan 4;115:13-23. Epub 2019 Jan 4.

Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna 9208, Bangladesh. Electronic address:

Disease fatality associated with Ebola, SARS-CoV and dengue infections in humans is attributed to a cytokine storm that is triggered by excessive pro-inflammatory responses. Interleukin (IL)-6 acts as a mediator between pro- and anti-inflammatory reactivity by initiating trans- and classical-signaling, respectively. Hence, IL-6 is assumed to provide a target for a broad range of antiviral agents. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.008DOI Listing
January 2019
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Lifelong exercise practice and immunosenescence: Master athletes cytokine response to acute exercise.

Cytokine 2019 Jan 4;115:1-7. Epub 2019 Jan 4.

Research Center for Sport and Physical Activity, Faculty of Sport Sciences and Physical Education, University of Coimbra, Coimbra, Portugal.

The study aimed to analyze the effects of aging and lifelong training on the main pro- and anti-inflammatory cytokines, and the impact of acute exercise on the expression of these cytokines. Thirty-nine participants were allocated into 3 groups: young (31.8 ± 3. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.006DOI Listing
January 2019
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Evaluation of the expression of cytokines and chemokines in macrophages in response to rifampin-monoresistant Mycobacterium tuberculosis and H37Rv strain.

Cytokine 2018 Dec 26. Epub 2018 Dec 26.

Department of Mycobacteriology and Pulmonary Research, Pasteur Institute of Iran, Tehran, Iran; Microbiology Research Center (MRC), Pasteur Institute of Iran, Tehran, Iran. Electronic address:

Macrophages are the primary phagocytes in the lungs and a part of the host defense system against Mycobacterium tuberculosis (Mtb), involved in the primary immune response. While several studies have assessed the effects of resistance to rifampin on Mtb physiology, the consequences of mutations in genes encoding the beta subunit of RNA polymerase (rpoB) for host-pathogen interactions remain poorly understood. In this study, rifampin-monoresistant (RMR) Mtb and H37Rv strains were used to infect the THP-1-derived macrophages. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.004DOI Listing
December 2018
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High expression of S100 calgranulins genes in peripheral blood mononuclear cells in patients with Takayasu arteritis.

Cytokine 2018 Dec 26;114:61-66. Epub 2018 Dec 26.

Department of Clinical Immunology and Rheumatology, Christian Medical College, Vellore, Tamil Nadu, India. Electronic address:

Background: Toll-like receptors (TLR) 1 to 4 are highly expressed in aorta. Activation of TLR4 causes transmural arteritis in Human temporal artery-SCID chimera model. Neither TLR-4 nor its ligands have been studied in TA patients as yet. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.033DOI Listing
December 2018
4 Reads

Interleukin 27 polymorphisms, their association with insulin resistance and their contribution to subclinical atherosclerosis. The GEA Mexican study.

Cytokine 2018 Dec 26;114:32-37. Epub 2018 Dec 26.

Departamento de Endocrinologia, Instituto Nacional de Cardiología Ignacio Chávez, Ciudad de Mexico, Mexico. Electronic address:

Our previous data suggest that the heterodimeric interleukin-27 (IL-27) could participate in the developing of insulin resistance (IR). Our aim was to assess the participation of IL-27p28 gene single nucleotide polymorphisms (SNPs) as markers for IR, subclinical atherosclerosis (SA) and cardiovascular risk factors in a Mexican population. Five IL-27p28 SNPs (rs153109, rs40837, rs17855750, rs26528 and rs181206) were genotyped in 856 individuals with IR and 644 participants without IR. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.028DOI Listing
December 2018
6 Reads
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Alveolar bone healing in mice genetically selected in the maximum (AIRmax) or minimum (AIRmin) inflammatory reaction.

Cytokine 2018 Dec 22;114:47-60. Epub 2018 Dec 22.

Department of Biological Sciences, Bauru School of Dentistry, University of São Paulo, Bauru, SP, Brazil. Electronic address:

The exact role of inflammatory immune response in bone healing process is still unclear, but the success of the alveolar bone healing process seems to be associated with a moderate and transitory inflammatory response, while insufficient or exacerbated responses seems to have a detrimental influence in the healing outcome. In this context, we performed a comparative analysis of mice strains genetically selected for maximum (AIRmax) or minimum (AIRmin) acute inflammatory response to address the influence of inflammation genes in alveolar bone healing outcome. Experimental groups comprised 8-week-old male or female AIRmax and AIRmin submitted to extraction of upper right incisor, and evaluated at 0, 3, 7, 14 and 21 days after upper incision extraction by micro-computed tomography (μCT), histomorphometry, birefringence, immunohistochemistry and molecular (PCRArray) analysis. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.027DOI Listing
December 2018
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Exogenous interleukin-1α signaling negatively impacts acquired chemoresistance and alters cell adhesion molecule expression pattern in colorectal carcinoma cells HCT116.

Cytokine 2018 Dec 21;114:38-46. Epub 2018 Dec 21.

Institute of Biosciences, Life Sciences Center, Vilnius University, Sauletekio al. 7, Vilnius 10227, Lithuania. Electronic address:

Proinflammatory cytokine and chemokine signaling from the tumor microenvironment is thought to be crucial for developing and sustaining colorectal cancer by regulating a multitude of pathways associated with a variety of cellular mechanisms. Among these pathways there is acquired chemoresistance, which is usually a major obstacle in the way towards successful chemotherapeutic treatment of advanced colorectal cancer cases. Despite of an emerging body of data published on the role of cytokine signaling network in cancer, little is known about the effects of the upstream cytokine interleukin-1α (IL-1α) signaling to the cancer cells. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.031DOI Listing
December 2018
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Procalcitonin levels predicting the infliximab response of immunoglobulin resistant Kawasaki disease.

Cytokine 2018 Dec 21;114:26-31. Epub 2018 Dec 21.

Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Objective: To search the predictive factors of infliximab resistance in intravenous immunoglobulin (IVIG)-resistant Kawasaki disease (KD) patients.

Study Design: Twenty-seven patients with KD who received infliximab after 4-5 g/kg of IVIG therapy from 2013 to 2015 were consecutively recruited in this study. They were divided into two groups: patients who responded to infliximab (infliximab-responsive group, n = 15) and patients who required additional therapy for the disease control (infliximab-resistant group, n = 12). Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.025DOI Listing
December 2018
9 Reads

Role of meprin metalloproteinases in cytokine processing and inflammation.

Cytokine 2018 Dec 20;114:18-25. Epub 2018 Dec 20.

Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, Department of Internal Medicine, Little Rock, AR, USA; Central Arkansas Veterans Healthcare System and University of Arkansas for Medical Sciences, Department of Biochemistry, Little Rock, AR, USA. Electronic address:

Meprin metalloendopeptidases, comprising α and β isoforms, are widely expressed in mammalian cells and organs including kidney, intestines, lungs, skin, and bladder, and in a variety of immune cells and cancer cells. Meprins proteolytically process many inflammatory mediators, including cytokines, chemokines, and other bioactive proteins and peptides that control the function of immune cells. The knowledge of meprin-mediated processing of inflammatory mediators and other target substrates provides a pathophysiologic link for the involvement of meprins in the pathogenesis of many inflammatory disorders. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.032DOI Listing
December 2018
7 Reads

Polymorphisms of suppressor of cytokine signaling-3 associated with susceptibility to tuberculosis among Han Taiwanese.

Cytokine 2018 Dec 20;114:11-17. Epub 2018 Dec 20.

Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan. Electronic address:

Background: Suppressors of cytokine signaling (SOCS), particularly SOCS-3, allow discrimination of patients with active tuberculosis (TB) from healthy subjects in a gender- and age-dependent manner. However, no information is available on whether single nucleotide polymorphisms (SNPs) in the SOCS-3 gene occur in patients with TB. This study was designed to investigate SOCS-3 SNPs in association with susceptibility to TB in the Taiwanese population. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.026DOI Listing
December 2018
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Editorial: Cytokines in liver diseases.

Cytokine 2018 Dec 15. Epub 2018 Dec 15.

Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD 21201, USA. Electronic address:

This special issue on 'Cytokines in Liver Diseases' was inspired by many talks and presentations on liver cancer during the 2nd Aegean Conference on Cytokine Signaling in Cancer (ACCSC) held at Heraklion, Crete, Greece on May 30-June 04, 2017 (Cytokine 2018, 108: 225-231). The liver is the biggest blood filtration and detoxification unit, and is a vital metabolic organ. Being constantly exposed to potentially harmful dietary chemicals, drugs, alcohol abuse and pathogens, the liver displays an extraordinary capacity to repair tissue damage and to regenerate. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.12.001DOI Listing
December 2018
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Endometrium cytokine profiles are altered following ovarian stimulation but almost not in subsequent hormone replacement cycles.

Cytokine 2018 Dec 15;114:6-10. Epub 2018 Dec 15.

Reproductive Medicine Center of Ruijin Hospital Affilited to Medical School of Shanghai Jiaotong University, Shanghai, China.

Purpose: To investigate the impact of ovarian stimulation and hormone replacement treatment on key regulatory cytokines in endometrial secretion during endometrium implantation window.

Methods: Fifty-six patients undergoing ovarian stimulation (OS) with gonadotropin releasing hormone antagonist and frozen embryo transfer with hormone replacement treatment (HRT) were recruited. Endometrial secretion aspiration was performed repeatedly during implantation window in natural, OS and HRT cycles of every patient. Read More

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http://dx.doi.org/10.1016/j.cyto.2018.11.002DOI Listing
December 2018
1 Read