2,447 results match your criteria Cystosarcoma Phyllodes


A retrospective review of phyllodes tumors of the breast from a single institution.

Breast Dis 2021 May 28. Epub 2021 May 28.

Department of Surgery, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia.

Background: Phyllodes tumors (PTs) are rare fibroepithelial breast tumors with diverse biological behavior.

Objective: This study aimed to analyze the characteristics, management, and outcome of phyllodes tumors.

Methods: Patients diagnosed with PTs in our institution from January 2013 to December 2017 were identified retrospectively by the ICD-10 code. Read More

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Molecular characterization of pleomorphic liposarcomatous differentiation in malignant phyllodes tumor of the breast: A case report.

Pathol Res Pract 2021 May 24;224:153489. Epub 2021 May 24.

Department of Pathology, The 960th Hospital of PLA, Jinan, 250031, China. Electronic address:

Phyllodes tumors of the breast are rare fibroepithelial tumors, and malignant phyllodes tumors occasionally exhibit heterogeneous differentiation. Here, we report a case of malignant phyllodes tumor with pleomorphic liposarcomatous differentiation, and examined the genomic features of both components using capture-based next-generation sequencing of 425 cancer-related genes. A 56-year-old woman presented with a palpable, asymptomatic nodule in the right breast measuring 4. Read More

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Squamous Metaplasia in a Borderline Phyllodes Tumor-an Undocumented Histological Finding in Male Breast: Report of a Case and Review of Literature.

Int J Surg Pathol 2021 Jun 3:10668969211022017. Epub 2021 Jun 3.

28730All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

Phyllodes tumor is a paradigm of fibroepithelial neoplasm that accounts for <1% of the breast neoplastic lesions usually detected in females and uncommonly in the male breast. The World Health Organization classifies the tumor into benign, borderline, and malignant based on the predefined morphological criteria. Squamous differentiation in phyllodes tumor is epithelial metaplasia, which has been occasionally documented in English literature. Read More

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A Giant, Complex Fibroepithelial Tumor of the Breast: Borderline Phyllodes Tumor Combined with Tubular Adenoma - a Rare Clinical Presentation of a Fibroepithelial Tumor of the Breast.

Acta Med Acad 2021 Apr;50(1):218-220

College of Medicine, QU Health, Qatar University, Doha, Qatar; Biomedical and Pharmaceutical Research Unit, QU Health, Qatar University, Doha, Qatar. ORCID: http://orcid.org/0000-0001-9743-7265.

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Preoperative interventional artery embolization for the treatment of a giant malignant phyllodes tumor: A case report.

Mol Clin Oncol 2021 Jul 11;15(1):133. Epub 2021 May 11.

First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan 650032, P.R. China.

Phyllodes tumors (PTs) are rare but complex fibroepithelial lesions of the breast. The present report describes an unusual case of a giant malignant PT with a rich blood supply treated with dominant blood supply internal thoracic artery interventional embolization before surgery. A 41-year-old woman without underlying systemic disease presented with a tumor >20 cm in diameter growing rapidly in the left breast. Read More

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High-risk lesions of the breast: concurrent diagnostic tools and management recommendations.

Insights Imaging 2021 May 26;12(1):63. Epub 2021 May 26.

Department of Biomedical Sciences and Morphologic and Functional Imaging, University of Messina, Messina, Italy.

Breast lesions with uncertain malignant behavior, also known as high-risk or B3 lesions, are composed of a variety of pathologies with differing risks of associated malignancy. While open excision was previously preferred to manage all high-risk lesions, tailored management has been increasingly favored to reduce overtreatment and spare patients from unnecessary anxiety or high healthcare costs associated with surgical excision. The purpose of this work is to provide the reader with an accurate overview focused on the main high-risk lesions of the breast: atypical intraductal epithelial proliferation (atypical ductal hyperplasia), lobular neoplasia (including the subcategories lobular carcinoma in situ and atypical lobular hyperplasia), flat epithelial atypia, radial scar and papillary lesions, and phyllodes tumor. Read More

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NCCN Guidelines® Insights: Breast Cancer, Version 4.2021.

J Natl Compr Canc Netw 2021 05 1;19(5):484-493. Epub 2021 May 1.

Research Advocacy Network.

The NCCN Guidelines for Breast Cancer include up-to-date guidelines for clinical management of patients with carcinoma in situ, invasive breast cancer, Paget disease, phyllodes tumor, inflammatory breast cancer, male breast cancer, and breast cancer during pregnancy. These guidelines are developed by a multidisciplinary panel of representatives from NCCN Member Institutions with breast cancer-focused expertise in the fields of medical oncology, surgical oncology, radiation oncology, pathology, reconstructive surgery, and patient advocacy. These NCCN Guidelines Insights focus on the most recent updates to recommendations for adjuvant systemic therapy in patients with nonmetastatic, early-stage, hormone receptor-positive, HER2-negative breast cancer. Read More

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Apatinib treatment is effective for metastatic malignant phyllodes tumors of the breast: a case report.

BMC Womens Health 2021 05 22;21(1):218. Epub 2021 May 22.

The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China.

Background: We report a rare case of malignant phyllodes tumors (MPT) with partial response to apatinib.

Case Presentation: A 26-year-old woman had a palpable mass in her right breast for over a year. After resection, pathology indicated malignant phyllodes tumor. Read More

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Giant breast fibroadenoma in pregnancy.

Ceska Gynekol 2021 ;86(2):114-117

Objective: To present unusual case of rapidly growing breast fibroadenoma during pregnancy.

Case Report: Breast fibroadenomas are hormone-dependent tumors which can grow rapidly during pregnancy. We present a case of giant fibroadenoma, first detected before pregnancy, which grew rapidly under the influence of pregnancy hormones and was excised in the third trimester. Read More

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Limited Reporting of Histopathologic Details in a Multi-Institutional Academic Cohort of Phyllodes Tumors: Time for Standardization.

Ann Surg Oncol 2021 May 14. Epub 2021 May 14.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA, USA.

Background: Phyllodes tumors are rare fibroepithelial neoplasms that are classified by tiered histopathologic features. While there are protocols for the reporting of cancer specimens, no standardized reporting protocol exists for phyllodes.

Methods: We performed an 11-institution contemporary review of phyllodes tumors. Read More

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A Case of Phyllodes Tumor of the Breast with Mixed Liposarcoma: Case Report and Literature Review.

Onco Targets Ther 2021 6;14:3003-3011. Epub 2021 May 6.

Department of Pathology, Shihezi University School of Medicine and the First Affiliated Hospital to Shihezi University School of Medicine, Shihezi, Xinjiang, 832002, People's Republic of China.

Phyllodes tumors (PTs) account for less than 1% of breast tumors, and malignant PTs account for even less. Here, we described an unusual case of malignant PT with mixed liposarcoma (myxoid liposarcoma [MLP] and pleomorphic liposarcoma [PLP]). A 52-year-old woman discovered a small lump in her left breast. Read More

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Re-evaluating tumors of purported specialized prostatic stromal origin reveals molecular heterogeneity, including non-recurring gene fusions characteristic of uterine and soft tissue sarcoma subtypes.

Mod Pathol 2021 May 13. Epub 2021 May 13.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

Tumors of purported specialized prostatic stromal origin comprise prostatic stromal sarcomas (PSS) and stromal tumors of uncertain malignant potential (STUMP). Prior studies have described their clinicopathologic characteristics, but the molecular features remain incompletely understood. Moreover, these neoplasms are morphologically heterogeneous and the lack of specific adjunctive markers of prostatic stromal lineage make precise definition more difficult, leading some to question whether they represent a specific tumor type. Read More

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Malignant Phyllodes of Breast.

Authors:
Cha Kyong Yom

Adv Exp Med Biol 2021 ;1187:601-612

Yom Breast Clinic, Seoul, South Korea.

Phyllodes tumors of breast (PTB) have been known to an uncommon and particular disease to handle owing to diagnostic ambiguity and unpredictable clinical outcome. Malignant phyllodes tumors (MPT) are diagnosed when there are marked stromal hypercellularity, atypia, increased mitoses of ≥10/10 HPFs, permeative tumor borders, and stromal overgrowth. The presence of a malignant heterologous element (MHE) places the tumor into the malignant category regardless of other histological features. Read More

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Giant lactating adenoma.

Autops Case Rep 2021 Apr 15;11:e2021252. Epub 2021 Apr 15.

Universidade Federal do Espírito Santo, Medical School, Department of Pathology, Vitória, ES, Brasil.

Lactating adenoma is a rare benign breast lesion that most often presents as a small (up to 3 cm), solid, well-circumscribed, solitary, painless, mobile, lobulated mass. The highest incidence occurs in primiparous women (20 to 40 years old) during the third trimester of pregnancy. However, in the rare case presented herein, in addition to its giant size (more than 10 centimeters on palpation), this lactating adenoma is distinctive due to the presence of multiple nodules, poorly defined ultrasonographic margins, worrisome radiologic features, growth since early pregnancy, presence of infarction and association with chronic mastitis. Read More

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A huge malignant phyllodes tumor of the breast with osteoclast-like giant cells: a case report.

Gland Surg 2021 Apr;10(4):1508-1514

Department of Breast Surgery, Second Affiliated Hospital of Dalian Medical University, Dalian, China.

The malignant phyllodes tumor (PT) of the breasts is a rare type of fibroepithelial neoplasm. Osteoclast-like giant cells (OLGCs) exist in many types of tumors. But malignant PTs with OLGCs were rarely reported. Read More

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Differential diagnosis between small breast phyllodes tumors and fibroadenomas using artificial intelligence and ultrasound data.

Quant Imaging Med Surg 2021 May;11(5):2052-2061

Department of Ultrasound, Peking University People's Hospital, Beijing, China.

Background: It is challenging to differentiate between phyllodes tumors (PTs) and fibroadenomas (FAs). Artificial intelligence (AI) can provide quantitative information regarding the morphology and textural features of lesions. This study attempted to use AI to evaluate the ultrasonic images of PTs and FAs and to explore the diagnostic performance of AI features in the differential diagnosis of PTs and FAs. Read More

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Malignant Phyllodes Tumor of the Breast: A Practice Review.

Clin Pract 2021 Apr 6;11(2):205-215. Epub 2021 Apr 6.

Department of Medical Oncology, A.C.Camargo Cancer Center, São Paulo 01525-001, Brazil.

Introduction: Phyllodes tumor (PT) of the breast, particularly malignant phyllodes tumor (mPT), is a rare fibroepithelial neoplasm. A complex diagnosis is based on pathologic, radiologic, and clinical findings, with controversies about what is the best therapeutic strategy.

Objective: Our objective was to provide an overview of the clinical, pathologic, and therapeutic aspects of this rare tumor. Read More

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Core needle biopsy in fibroepithelial tumors: predicting factors for phyllodes tumors.

Clinics (Sao Paulo) 2021 16;76:e2806. Epub 2021 Apr 16.

Disciplina de Ginecologia, Departamento de Obstetricia e Ginecologia, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, BR.

Objectives: This study aimed to evaluate the clinical and imaging predictive factors for the diagnosis of phyllodes tumors in patients with inconclusive results from core needle biopsy (fibroepithelial lesions).

Methods: We retrospectively analyzed data of patients who underwent surgical excision of breast lesions previously diagnosed as fibroepithelial lesions. Numeric variables were analyzed using the Shapiro-Wilk and t-tests, and categorical variables were analyzed using the chi-square and Fisher's exact tests. Read More

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Phyllodes tumor of the vulva: A case report and literature review highlighting a novel manifestation of Cowden syndrome.

Gynecol Oncol Rep 2021 May 23;36:100752. Epub 2021 Mar 23.

Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago, Chicago, IL, USA.

Cowden syndrome is a rare hereditary cancer syndrome characterized by a germline mutation which results in an increased risk of developing breast, thyroid, and endometrial carcinoma, as well as widespread benign hamartomas. Phyllodes tumor (PT) is a rare fibroepithelial tumor that accounts for less than 1% of all breast tumors. As mammary-type glands can be found in the anogenital region, PTs can rarely arise in this location. Read More

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Intra-mammary lymph nodes, an overlooked breast cancer prognostic tool?

World J Surg Oncol 2021 Apr 13;19(1):114. Epub 2021 Apr 13.

Pathology Department, National Cancer Institute-Cairo University, Cairo, Egypt.

Background: Due to the high variability of incidence and prevalence of intra-mammary lymph nodes (IMLNs), they might be overlooked during clinical and radiological examinations. Properly characterizing pathological IMLNs and detecting the factors that might influence their prevalence in different stages of breast cancer might aid in proper therapeutic decision-making and could be of possible prognostic value.

Methods: Medical records were reviewed for all breast cancer patients treated at the National Cancer Institute of Cairo University between 2013 and 2019. Read More

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SETD2 alterations and histone H3K36 trimethylation in phyllodes tumor of breast.

Breast Cancer Res Treat 2021 Jun 12;187(2):339-347. Epub 2021 Apr 12.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Ngan Shing Street, Shatin, NT, Hong Kong SAR.

Purpose: SETD2 is one of the key epigenetic regulatory genes involved in histone modifications. Its alterations were potentially oncogenic and commonly found in cancers. Interestingly, SETD2 is one of the most frequent mutated genes found exclusively in phyllodes tumor of the breast (PT). Read More

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A Giant Borderline Phyllodes Tumor of Breast With Skin Ulceration Leading to Non-Insular Tumorigenic Hypoglycemia: A Case Report and Literature Review.

Front Endocrinol (Lausanne) 2021 25;12:651568. Epub 2021 Mar 25.

Department of Pathology, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

Phyllodes tumor (PT) is a special type of breast tumors, including three types: malignant, borderline, and benign. Most of these tumors form unilateral disease and can rapidly increase in size. The occurrence of axillary lymph node metastasis is rare. Read More

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[Updated WHO classification of tumors of the breast: the most important changes].

Pathologe 2021 May 6;42(3):270-280. Epub 2021 Apr 6.

Institut für Pathologie, Philipps-Universität Marburg und Universitätsklinikum Marburg, Marburg, Deutschland.

The development of the WHO classification of tumors of the breast is driven by new knowledge from research whose translation into daily practice is considered clinically relevant. The fifth edition represents an update of the fourth edition and essentially follows the previously known systematics. The histologic features of the lesions continue to form the basis of the classification in the update. Read More

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Clinical Features of Breast Cancer in South Korean Patients with Germline Gene Mutations.

J Breast Cancer 2021 Apr 12;24(2):175-182. Epub 2021 Mar 12.

Division of Breast Surgery, Department of Surgery, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Purpose: Li-Fraumeni syndrome (LFS) is a rare autosomal cancer syndrome caused by a germline mutation in the gene. Breast cancer in LFS patients is of various subtypes; however, limited data are available on the clinicopathological features of these subtypes and their appropriate treatments. This study aimed to review the clinical features and treatments for breast cancer in South Korean patients with germline mutations. Read More

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Report of Two Cases with Simultaneously Detected Tubular Carcinoma and Phyllodes Tumor of the Breast.

Eur J Breast Health 2021 Jan 24;17(1):80-83. Epub 2020 Dec 24.

Clinic of Radiology, University of Health Sciences Turkey, Haseki Training and Research Hospital, Istanbul, Turkey.

Tubular carcinoma (TC) is a subtype of invasive breast carcinoma with better prognosis, and phyllodes tumors (PT) are rare fibroepithelial lesions. Accurate preoperative pathological diagnosis allows for correct surgical planning and avoidance of reoperation for these breast neoplasms. A database was created by analyzing the archives of Department of General Surgery of the İstanbul Faculty of Medicine between September 2006 and November 2017, and a total of 105 PTs and 55 TCs were collected. Read More

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January 2021

Phyllodes Tumors of the Breast: A Single-Center Experience.

Eur J Breast Health 2021 Jan 24;17(1):36-41. Epub 2020 Dec 24.

Department of General Surgery, Pamukkale University Faculty of Medicine, Denizli, Turkey.

Objective: We aimed to analyze the clinicopathological findings, treatment approach, and treatmen outcomes in patients diagnosed with phyllodes tumor (PT).

Materials And Methods: The clinicopathological data of 26 patients with PT, who were treated between 2008 and 2019, were retrospectively analyzed.

Results: Mean age was 35. Read More

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January 2021

Predictive Factors of Early Recurrence in Patients with Phyllodes Tumor of the Breast.

Eur J Breast Health 2021 Jan 24;17(1):10-14. Epub 2020 Dec 24.

Clinic of General Surgery, St. John's Medical College Hospital, Bangalore, Karnataka, India.

Objective: Phyllodes tumor (PT) is a rare entity accounting for 1% of breast neoplasms with a high propensity of recurrence. This study aimed to identify factors that are predictive of early recurrence in patients with PT.

Materials And Methods: This study reviewed clinical data of patients with PT (n=57) treated at our tertiary care referral center in South India between February 2010 and December 2019. Read More

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January 2021

[A Case of a Malignant Phyllodes Tumor in the Breast with Lymph Node Metastasis].

Gan To Kagaku Ryoho 2021 Mar;48(3):437-439

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

A 52-year-old woman experienced right breast pain and detected a mammary tumor 6 months ago. She then noticed rapid enlargement of the tumor, which was suspected to be a borderline malignant phyllodes tumor. The tumor size was approximately 15 cm and presented with skin congestion but without infiltration. Read More

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Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature.

Case Rep Oncol 2021 Jan-Apr;14(1):123-133. Epub 2021 Mar 1.

Service of Anatomical Pathology, Medica Sur Clinic and Foundation, Mexico, Mexico.

Phyllodes tumor of the breast is an infrequently encountered fibroepithelial neoplasm, which accounts for 0.3-1% of all tumors. Few case reports have described the occurrence of giant phyllodes tumor. Read More

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GATA binding protein 3 (GATA3) as a marker for metaplastic spindle cell carcinoma of the breast.

Pathol Res Pract 2021 May 20;221:153413. Epub 2021 Mar 20.

Department of Pathology and Laboratory Medicine, Donald and Barbara Zucker School of Medicine at Northwell, United States.

Spindle cell lesions of the breast comprise a diverse set of tumors; harboring significant histological and immunohistochemical (IHC) overlap. Accurate diagnosis and classification of spindle cell lesions in the breast remains challenging, especially in core biopsies. In the current study, we evaluated a spectrum of spindle cell lesion of the breast with a panel of IHC antibodies in an effort to differentiate metaplastic spindle cell carcinoma from its benign and malignant mimickers. Read More

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