2,337 results match your criteria Cystosarcoma Phyllodes


Phyllodes Tumor of the Breast during Pregnancy and Lactation; A Systematic Review.

Arch Iran Med 2020 Jul 1;23(7):488-497. Epub 2020 Jul 1.

First Department of Surgery, Faculty of Medicine, University of Yamanashi, Shimokato, Chuo, Yamanashi, Japan.

Background: Phyllodes tumor (PT) is a rare tumor of the breast, which may occur during pregnancy or lactation. Several studies have reviewed and discussed PT occurring in pregnancy, gathering up to 14 patients. We performed a thorough systematic review of the literature in an attempt to find all reported cases, and identify their common characteristics. Read More

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http://dx.doi.org/10.34172/aim.2020.46DOI Listing

Histopathologic, immunophenotypic, and proteomics characteristics of low-grade phyllodes tumor and fibroadenoma: more similarities than differences.

NPJ Breast Cancer 2020 26;6:27. Epub 2020 Jun 26.

Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110 USA.

Distinguishing low-grade phyllodes tumor from fibroadenoma is practically challenging due to their overlapping histologic features. However, the final interpretation is essential to surgeons, who base their management on the final pathology report. Patients who receive a diagnosis of fibroadenoma might not undergo any additional intervention while lumpectomy with wide margins is the standard of care for phyllodes tumor, which can have significant cosmetic consequences. Read More

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http://dx.doi.org/10.1038/s41523-020-0169-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319981PMC

Application of periareolar mastopexy technique for giant phyllodes tumor resection in an adolescent female with breast asymmetry: a case report and literature review.

J Egypt Natl Canc Inst 2020 Jun 29;32(1):27. Epub 2020 Jun 29.

General Surgery Department, Faculty of Medicine, Qena University Hospital, South Valley University, Qena, Egypt.

Background: The phyllodes tumors are rare neoplastic disease which exhibits a benign behavior in adolescents female. After resection of a large benign breast tumor, insufficient breast contour may result with nipple areola complex malposition. As symmetry of the breast is psychologically extremely crucial, especially in adolescents, in such cases, an immediate mammoplasty-like breast reduction or mastopexy technique of the affected breast will be necessary to provide symmetry of the bilateral breasts at the initial surgery. Read More

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http://dx.doi.org/10.1186/s43046-020-00036-2DOI Listing

Cutaneous Scalp Metastases of Malignant Phyllodes Tumor of the Breast.

J Breast Cancer 2020 Jun 27;23(3):320-325. Epub 2020 Feb 27.

Department of Surgery, Chonnam National University Hwasun Hospital, Chonnam National University Medical School, Hwasun, Korea.

Phyllodes tumor (PT) of the breast is a relatively rare fibroepithelial tumor that accounts for < 1% of primary breast neoplasms. PT is classified histologically as benign, borderline, or malignant, and a malignant PT has greater potential to metastasize than benign PT. Although almost all other organs can be affected, common metastatic sites are the lung and bone via the hematogenous route. Read More

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http://dx.doi.org/10.4048/jbc.2020.23.e18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311367PMC

Pure ground glass opacity (GGO) on chest CT: a rare presentation of lung metastasis of Malignant Phyllodes Tumor.

Breast Cancer 2020 Jun 23. Epub 2020 Jun 23.

Breast Center, Kin-Ikyo Chuo Hospital, 5-1-9-1 Higashinaebo, Higashi-ku, Sapporo, 007-8505, Japan.

Lung is the most common target organ for distant metastasis of phyllodes tumor (PT), where the metastatic tumors are mostly seen as nodules or masses. We report here a rare case in which pure ground-glass opacity (GGO) was observed on chest CT about 3 years after the initial treatment of breast PT. After the lung lobectomy, we histologically confirmed that it should be diagnosed as a metastasis of PT. Read More

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http://dx.doi.org/10.1007/s12282-020-01122-yDOI Listing

Periductal Stromal Tumors and Phyllodes Tumors Represent a Spectrum of Fibroepithelial Lesions: What Is in a Name?

Int J Surg Pathol 2020 Jun 9:1066896920929086. Epub 2020 Jun 9.

Cliniques Universitaires Saint-Luc, Brussels, Belgium.

Periductal stromal tumors (PSTs) of the breast are considered as a rare subtype of phyllodes tumors. These rare fibroepithelial lesions display a biphasic morphology, characterized by a cellular stroma surrounding benign ducts. Unlike phyllodes tumors, they do not present with a leaflike architecture, rendering a biopsy diagnosis of a PST very challenging. Read More

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http://dx.doi.org/10.1177/1066896920929086DOI Listing

Next-generation sequencing in residual liquid-based cytology specimens for cancer genome analysis.

Diagn Cytopathol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pathology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan.

Background: Cancer genome profiling of cytology specimens using next-generation sequencing (NGS) requires adequate and good-quality DNA. Genomic examination of cytology samples was conventionally performed on cell block (CB) or smear specimens than on residual liquid-based cytology (LBC) specimens, which are high-quality DNA sources even after long-term storage.

Methods: We estimated tumor fractions of 37 residual LBC specimens, including 30 fine needle aspiration (FNA) samples from the thyroid (12 papillary thyroid carcinomas and two malignant lymphomas), lymph node (13 metastatic carcinomas and one malignant lymphoma), and breast cancer (one phyllodes tumor and one invasive ductal carcinoma), two pancreatic carcinoma samples, and five liquid (ascites, pleural effusion, and cerebrospinal fluid) samples. Read More

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http://dx.doi.org/10.1002/dc.24511DOI Listing

Risk Factors for Disease Recurrence in Women With Phyllodes Tumors of the Breast in Southern Colombia: A Nine-Year Cohort Study.

Cureus 2020 May 4;12(5):e7951. Epub 2020 May 4.

Cardiac Surgery, Clínica Medilaser, Neiva, COL.

Introduction Phyllodes tumors (PTs) are uncommon fibroepithelial breast tumors that occur in middle-aged women, and they tend to vary in biologic behavior. Surgical management is the standard therapy for the condition, but factors associated with recurrence remain unclear. The aim of this study was to evaluate clinical and surgical characteristics related to PT recurrences. Read More

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http://dx.doi.org/10.7759/cureus.7951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7271061PMC

Magnetic resonance imaging semantic and quantitative features analyses: an additional diagnostic tool for breast phyllodes tumors.

Am J Transl Res 2020 15;12(5):2083-2092. Epub 2020 May 15.

Department of Bone and Soft Tissue Tumors, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer Tianjin, P. R. China.

Objective: This study aimed to differentiate benign and non-benign (borderline/malignant) phyllodes tumors of the breast by the semantic and quantitative features in magnetic resonance imaging (MRI).

Methods: The female patients, diagnosed with phyllodes tumors by MRI and pathological test, were retrospectively selected from December, 2006 to April, 2019. The MRI of benign, borderline and malignant phyllodes tumors was analyzed using 8 semantic features and 20 computed quantitative features from diffuse contrast-enhanced magnetic resonance imaging (DCE-MRI). Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7270016PMC
May 2020
3.226 Impact Factor

Multifocal intra-parenchymal and sub-pectoral malignant phyllodes tumor in young female, rare and unusual presentation: A case report.

Int J Surg Case Rep 2020 22;71:280-284. Epub 2020 May 22.

General Surgery Resident, Jordan Ministry of Health, Jordan.

Introduction: Phyllodes tumors are rare fibroepithelial breast tumors, accounting for less than 1% of all breast tumors. Most Phyllodes tumors are benign. However, about 10% are malignant. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.05.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264011PMC

The Reconstruction after a Giant Phyllodes Tumor Resection Using a DIEP Flap.

Plast Reconstr Surg Glob Open 2020 Apr 27;8(4):e2760. Epub 2020 Apr 27.

Department of Plastic and Reconstructive Surgery, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan.

A phyllodes tumor of the breast is a rare neoplasm, accounting for 0.3%-1% of all breast cancers. The size is 4-5 cm on average but sometimes the tumor grows more and involves the entire breast. Read More

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http://dx.doi.org/10.1097/GOX.0000000000002760DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7209875PMC

Comparison of mutation profile between primary phyllodes tumors of the breast and their paired local recurrences.

Pol J Pathol 2020 ;71(1):7-12

Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland.

Phyllodes tumor of the breast (PTB) is a rare neoplasm and accounts for 0.2-2.0% of breast cancer in women. Read More

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http://dx.doi.org/10.5114/pjp.2020.94899DOI Listing
January 2020

Recurrent borderline phyllodes tumor in nipple: a rare case report and review of the literature.

Gland Surg 2020 Apr;9(2):452-458

Department of Breast Surgery, China-Japan Union Hospital, Jilin University, Changchun 130033, China.

Phyllodes tumor (PT) of the breast is a rare tumor. They are usually located in the four quadrants of the mammary gland and may also appear below the nipple. Although there have been a number of cases reported, here we report a very rare case of this tumor in an unusual location. Read More

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http://dx.doi.org/10.21037/gs.2020.01.17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225488PMC

Cellular fibroepithelial lesions diagnosed on core needle biopsy: Is there any role of clinical-sonography features helping to differentiate fibroadenomas and phyllodes tumor?

J Surg Oncol 2020 May 12. Epub 2020 May 12.

Joint Department of Medical Imaging, Mount Sinai Hospital, Women's College Hospital, University of Toronto, University Health Network, Toronto, Ontario, Canada.

Objective: The purpose of this study is to determine the role of clinico-sonographic features of breast cellular fibroepithelial lesions (CFELs) diagnosed on core needle biopsy (CNB) in the differentiation between fibroadenoma (FA) and phyllodes.

Materials And Methods: Results of consecutive women with a CNB showing CFEL from 2005 to 2010 were retrospectively reviewed. Clinical and sonographic findings were compared with surgical outcomes. Read More

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http://dx.doi.org/10.1002/jso.25977DOI Listing

[Research progress of biomarkers in breast phyllodes tumours].

Zhonghua Bing Li Xue Za Zhi 2020 05;49(5):507-510

Department of Pathology/Pathology Laboratory, West China Hospital, Sichuan University, Chengdu 610041, China.

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http://dx.doi.org/10.3760/cma.j.cn112151-20200112-00029DOI Listing

[Phyllodes Tumor of the Breast Occurring near Postoperative Fibroadenoma Scar-A Case Report].

Gan To Kagaku Ryoho 2020 Jan;47(1):150-152

Dept. of Surgery, Nippon Dental University Hospital.

We report the case of a phyllodes tumor of the breast occurring near a postoperative scar of fibroadenoma of the breast. The patient was a 41-year-old female who had a lump in the left breast, and underwent surgical resection of the tumor 5 years ago at another hospital.The pathological diagnosis of the tumor was fibroadenoma, and surgical margin was negative. Read More

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January 2020

Re-excision or "wait and watch"-a prediction model in breast phyllodes tumors after surgery.

Ann Transl Med 2020 Mar;8(6):371

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, China.

Background: The prognosis of breast phyllodes tumors (PTs) largely depending on the pathological grading, which lacks objectivity. This study aimed to develop a nomogram based on clinicopathological features to evaluate the recurrence probability of PTs following surgery.

Methods: Data from 334 patients with breast PTs, who underwent surgical treatment at Sun Yat-sen Memorial Hospital from January 2005 to December 2014, were used to develop a prediction model. Read More

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http://dx.doi.org/10.21037/atm.2020.02.26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7186749PMC

Texture Analysis of Ultrasound Images to Differentiate Simple Fibroadenomas From Complex Fibroadenomas and Benign Phyllodes Tumors.

J Ultrasound Med 2020 Apr 24. Epub 2020 Apr 24.

Department of Radiology, Dokuz Eylul University School of Medicine, Izmir, Turkey.

Objectives: American College of Radiology Breast Imaging Reporting and Data System (BI-RADS) category 4A lesions can be distinguished from BI-RADS 3 lesions with main ultrasound (US) findings such as a well-defined contour, round/oval shape, and parallel orientation with a homogeneous echo pattern. Breast Imaging Reporting and Data System 4A solid masses might be diagnosed as simple fibroadenomas (SFAs), complex fibroadenomas (CFAs), or benign phyllodes tumors (BPTs). Complex fibroadenomas have an increased risk of invasive cancer development than SFAs, and BPTs have a risk of borderline-malignant phyllodes tumor transformation; both of them are surgically treated, whereas follow-up procedures are applied in SFAs. Read More

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http://dx.doi.org/10.1002/jum.15304DOI Listing

Management of a periductal stromal tumor in a young woman: Our breast unit experience.

Breast J 2020 Apr 16. Epub 2020 Apr 16.

Breast Unit, Breast Imaging Department of Radiology, University Hospital of Parma, Parma, Italy.

Periductal stromal tumor (PDST) is a rare biphasic tumor of the breast that exhibits low-grade malignancy and intermediate behavior. It is characterized by proliferation of atypical spindle cells surrounding benign mammary ducts and infiltrating adjacent adipose tissue. PDST is distinguished from phyllodes tumor by its lack of leaf-like architecture; however, it is still unclear whether PDST is a separate entity or a certain spectrum of phyllodes tumor. Read More

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http://dx.doi.org/10.1111/tbj.13843DOI Listing

Giant phyllodes tumor occupying the whole breast in a young female: feasibility of mastectomy and immediate reconstruction.

J Surg Case Rep 2020 Apr 6;2020(4):rjz410. Epub 2020 Apr 6.

1st Department of Propaedeutic Surgery, 'Hippocratio' General Hospital, Medical School, National and Kapodistrian University of Athens, Greece.

Giant phyllodes tumors are rare fibroepithelial breast neoplasms typically >10 cm by definition. The best investigation for preoperative diagnosis is core biopsy, although it is often difficult for the pathologist to distinguish fibroadenomas from phyllodes tumors and determine the level of malignant potential. The wide excision is the appropriate therapy for phyllodes tumors taking into consideration that mastectomy may be required for huge phyllodes tumors. Read More

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http://dx.doi.org/10.1093/jscr/rjz410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7135843PMC

Phyllodes tumors of the breast: a retrospective analysis of 57 cases.

Breast Cancer Res Treat 2020 Jun 10;181(2):361-367. Epub 2020 Apr 10.

Department of Surgery, OLVG, Jan Tooropstraat 164, 1061 AE, Amsterdam, The Netherlands.

Introduction: Current guidelines for the treatment of phyllodes tumors recommend wide local excision for all histopathological subtypes. However, it is unknown which subtypes have tendency to recur after marginal or incomplete excision. This may lead to over-treatment by re-excision surgery for tumors with little or no potential to recur. Read More

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http://dx.doi.org/10.1007/s10549-020-05620-7DOI Listing

Patterns of care and predictors of adjuvant radiation therapy in phyllodes tumor of the breast.

Breast J 2020 Apr 10. Epub 2020 Apr 10.

Department of Radiation Oncology, Dana-Farber/Brigham and Women's Cancer Center, Boston, MA, USA.

Patterns of care, utilization, and predictors of adjuvant radiation therapy (RT) for phyllodes tumors of the breast were retrospectively analyzed using the National Cancer Database. We identified 3080 patients; 53.4% received lumpectomy and 35. Read More

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http://dx.doi.org/10.1111/tbj.13830DOI Listing

Vulvar Phyllodes Tumor Presenting as an Epidermoid Cyst.

J Cutan Pathol 2020 Apr 5. Epub 2020 Apr 5.

Department of Dermatology, University of Texas Southwestern Medical Center.

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http://dx.doi.org/10.1111/cup.13699DOI Listing
April 2020
1.560 Impact Factor

ASO Author Reflections: How Far Should We Go in Local Management for a Localized Malignant Phyllodes Tumor of the Breast?

Ann Surg Oncol 2020 Jun 23;27(6):1828-1829. Epub 2020 Mar 23.

IRCM, Inserm, ICM, Univ Montpellier, Montpellier, France.

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http://dx.doi.org/10.1245/s10434-020-08390-0DOI Listing

Malignant Phyllodes Tumor in an Adolescent Female: A Rare Case Report and Review of the Literature.

Case Rep Oncol Med 2020 28;2020:1989452. Epub 2020 Feb 28.

Cooper University Hospital, Department of Pathology, 1 Cooper Plaza, Camden, NJ 08103, USA.

Primary breast neoplasms are rare in adolescent females, most of which are benign. Phyllodes tumors constitute a remarkably small subset of breast neoplasms (0.3-0. Read More

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http://dx.doi.org/10.1155/2020/1989452DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7064852PMC
February 2020

Counting Mitoses With Digital Pathology in Breast Phyllodes Tumors.

Arch Pathol Lab Med 2020 Mar 9. Epub 2020 Mar 9.

From the Department of Anatomical Pathology (Mr Chow, Drs Thike and Tan, and Ms Nasir), Division of Pathology (Drs Yeong and Tan), and Division of Research (Dr Li), Singapore General Hospital, Singapore; the Institute of Molecular and Cell Biology (IMCB), Agency of Science, Technology and Research (ASTAR), Singapore (Dr Yeong); the Duke-NUS Medical School, Singapore (Drs Thike and Tan); and the University of Tasmania, Tasmania, Australia (Mr Chow).

Context.—: Mitotic count is an important histologic criterion for grading and prognostication in phyllodes tumors (PTs). Counting mitoses is a routine practice for pathologists evaluating neoplasms, but different microscopes, variable field selection, and areas have led to possible misclassification. Read More

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http://dx.doi.org/10.5858/arpa.2019-0435-OADOI Listing
March 2020
2.838 Impact Factor

[Phyllodes tumor of the breast with heart and lung metastases: a case report].

Zhonghua Nei Ke Za Zhi 2020 Mar;59(3):229-231

Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing100730, China.

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http://dx.doi.org/10.3760/cma.j.issn.0578-1426.2020.03.013DOI Listing

Phyllodes tumours of the breast: Outcomes and recurrence after excision.

Am J Surg 2020 05 28;219(5):790-794. Epub 2020 Feb 28.

Providence Breast Centre, Mount Saint Joseph Hospital, 3080 Prince Edward Street, Vancouver, BC, V5T 3N4, Canada; Department of Surgery, Faculty of Medicine, University of British Columbia, 2775 Laurel Street, Vancouver, BC, V5Z 1M9, Canada. Electronic address:

Introduction: Wide excision margins are traditionally recommended for phyllodes tumours of the breast to reduce recurrence. Recent studies suggest margin status and histopathological features, excluding margin width, influence recurrence. This study evaluated treatment outcomes for phyllodes tumours and examined predictors of recurrence. Read More

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http://dx.doi.org/10.1016/j.amjsurg.2020.02.048DOI Listing

Expression changes of BIK in breast cancer tissues of different histological subtypes.

Cir Cir 2020 ;88(2):163-169

Laboratorio de Genómica Funcional, Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría "Silvestre Frenk Freund", Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Ciudad de México.

Objective: The objective of the study was to determine the expression levels of BIK in breast cancer (BC) tissues of different histological subtype and to delve into the participation of BIK in this type of cancer.

Materials And Methods: BIK and p-BIK (the phosphorylated form) protein expressions were tested by immunohistochemistry in BC tissue microarrays (Tumoral [n = 90] and adjacent [n = 40] tissues).

Results: The data revealed an overexpression of BIK in invasive ductal (Grades I, IIA, and IIB) and in lobular (Grades IIA and IIB) carcinomas compared to their respective adjacent tissues. Read More

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http://dx.doi.org/10.24875/CIRU.19001039DOI Listing
January 2020
0.322 Impact Factor

Rapidly progressing malignant phyllodes tumor of the prostate with normal prostate-specific antigen levels: A case report.

Indian J Pathol Microbiol 2020 Feb;63(Supplement):S50-S52

Department of Neurology, Jiujiang University Clinical Medical College, Jiujiang, China.

Malignant phyllodes tumor of the prostate is a very rare entity. Here, we describe a 51-year-old patient with a malignant phyllodes tumor of the prostate with a poor prognosis and normal prostate-specific antigen levels. Digital rectal examination revealed a hard, nodular mass in the prostate, and magnetic resonance imaging exhibited a cystic mass measuring 8. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_427_18DOI Listing
February 2020

A Radiomics Approach for the Classification of Fibroepithelial Lesions on Breast Ultrasonography.

Ultrasound Med Biol 2020 May 24;46(5):1133-1141. Epub 2020 Feb 24.

Department of Radiology, Research Institute of Radiological Science and Center for Clinical Image Data Science, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea. Electronic address:

A radiomics-based classifier to distinguish phyllodes tumor and fibroadenoma on gray-scale breast ultrasonography was developed and validated. A total of 93 radiomics features were extracted from representative transverse plane ultrasound images of 182 fibroepithelial lesions initially diagnosed by core needle biopsy. High-throughput radiomics features were selected using the intra-class correlation coefficient between two radiologist readers and the Least Absolute Shrinkage and Selection Operator regression through 10-fold cross-validation. Read More

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http://dx.doi.org/10.1016/j.ultrasmedbio.2020.01.015DOI Listing

Pulmonary Adenofibromas: A Clinicopathologic Correlation of 13 Cases.

Am J Surg Pathol 2020 Jul;44(7):917-921

Department of Pathology, MD Anderson Cancer Center, University of Texas, Houston, TX.

Thirteen cases of primary pulmonary adenofibromas are presented. The patients are 8 women and 5 men between the ages of 41 and 73 years (average: 57 y). The patients presented with nonspecific symptomatology or their tumor was identified during routine chest films. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001456DOI Listing

Phyllodes Tumors-The Predictors and Detection of Recurrence.

Can Assoc Radiol J 2020 Feb 24:846537119899553. Epub 2020 Feb 24.

Department of Medical Imaging, The University of Ottawa, Ottawa, General Campus, Ontario, Canada.

Background: Phyllodes tumors are rare breast neoplasms and the histopathological grade and surgical margins help guide treatment and follow-up. The traditional surgical teaching is resection with ≥10 mm margins, but are narrower surgical margins acceptable? The purpose of our study was to identify predictors of local recurrence.

Methods: A retrospective analysis was performed to identify patients with phyllodes tumors who underwent surgery between 2002 and 2014 using a regional pathology database. Read More

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http://dx.doi.org/10.1177/0846537119899553DOI Listing
February 2020

[Effect of ultrasound-guided vacuum-assisted excision verus open surgery for benign phyllodes tumors of breast on postoperative local recurrence].

Zhonghua Wai Ke Za Zhi 2020 Feb;58(2):110-113

Department of Breast Diseases, Guangdong Women and Children Hospital, Guangzhou Medical University, Guangzhou 510010, China.

To examine the effect of VAE and open surgery on the postoperativelocal recurrence of benign phyllodes tumors of breast and to investigate the clinical efficacy of VAE in the treatment of benign phyllodes tumors. The clinical data of 128 patients with benign phyllodes tumors of breast admitted to the Guangdong Women and Children Hospital from January 2013 to January 2018 were retrospectively analyzed. All patients were female, aged (37. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5815.2020.02.007DOI Listing
February 2020

Malignant giant phyllodes tumor with heterologous osteosarcomatous differentiation and aneurysmatic bone cyst-like features.

Authors:
Juan B Laforga

Breast J 2020 Feb 18. Epub 2020 Feb 18.

Servicio de Patología, Hospital de Dénia, Denia, Spain.

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http://dx.doi.org/10.1111/tbj.13788DOI Listing
February 2020

Benign phyllodes tumor with hemorrhagic cyst in a 14-year-old girl: A case report.

Int J Surg Case Rep 2020 6;67:114-116. Epub 2020 Feb 6.

Department of Breast Surgery, Hiratsuka City Hospital, Hiratsuka, Japan. Electronic address:

Introduction: The incidence of mammary phyllodes tumor is less than 0.3-0.5% of all breast tumors. Read More

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http://dx.doi.org/10.1016/j.ijscr.2020.01.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016342PMC
February 2020

Characterizing excised breast masses in children and adolescents-Can a more aggressive pathology be predicted?

J Pediatr Surg 2020 Jan 29. Epub 2020 Jan 29.

Department of General Surgery, Shamir (Assaf Harofeh) Medical Center, Zerifin, Be'er Ya'akov, Israel, affiliated with Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Purpose: Our aim was to characterize excised breast masses in children and adolescent and to identify factors associated with a more aggressive pathology.

Methods: Retrospective review of all female patients <19 who underwent excision of breast masses at our institution between 1999 and 2018. Demographic, clinical, imaging, pathological and management data were collected. Read More

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http://dx.doi.org/10.1016/j.jpedsurg.2020.01.012DOI Listing
January 2020

Malignant Phyllodes Tumor of the Breast in a 26-year-old Woman.

Cureus 2020 Jan 7;12(1):e6590. Epub 2020 Jan 7.

Radiology, University of Texas Medical Branch, Galveston, USA.

Breast cancer is the most commonly diagnosed cancer and the second leading cause of cancer death in women. Early detection, accurate diagnosis and proper treatment are important prognostic factors due to the wide variety of breast cancer subtypes. This becomes of particular importance with rare breast tumors, which are difficult to diagnose due to their varying presentations. Read More

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http://dx.doi.org/10.7759/cureus.6590DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7001134PMC
January 2020

Lacrimal Sac Metastasis from Phyllodes Tumor of the Breast.

Korean J Ophthalmol 2020 02;34(1):85-87

Department of Ophthalmology and Inha Vision Science Laboratory, Inha University School of Medicine, Incheon, Korea.

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http://dx.doi.org/10.3341/kjo.2019.0077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7010468PMC
February 2020

Primary Osteosarcoma of the Breast with Extensive Chondroid Matrix in a Teenager Female Patient: The Paradoxical Diagnosis in Breast Mastopathy.

Int Med Case Rep J 2020 10;13:11-17. Epub 2020 Jan 10.

Department of Pathology, Makerere College of Health Sciences (MakCHS), Kampala, Uganda.

Purpose: Non-epithelial tumors of the breast are extremely rare and have an incidence of less than 1%. The most common non-epithelial breast tumor is the phyllodes tumor (PT), which accounts for 61%. Primary osteosarcomas of the breast contribute up to only 12. Read More

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http://dx.doi.org/10.2147/IMCRJ.S233674DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959500PMC
January 2020

A Pre-operative Score to Discriminate Fibroepithelial Lesions of the Breast: Phyllode Tumor or Fibroadenoma?

Anticancer Res 2020 Feb;40(2):1095-1100

Department of Surgical Oncology, Rene Huguenin, Saint-Cloud, France.

Background/aim: Fibroepithelial lesions (FEL) of the breast include fibroadenomas and phyllodes tumors (PT). Their histologic characteristics on core needle biopsy can overlap, while their clinical management is different. The aim of this study was to develop and to validate a pre-operative score for the diagnosis of PT with surgical decision rules. Read More

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http://dx.doi.org/10.21873/anticanres.14048DOI Listing
February 2020

Radiotherapy with apatinib for recurrence of malignant phyllodes tumor of the breast: A case report.

Medicine (Baltimore) 2020 Jan;99(3):e18808

Department of Orthopedic trauma, Affiliated Hospital of Binzhou Medical University, Binzhou, China.

Rationale: Malignant phyllodes tumors of the breast are rare, and there are currently no guidelines and a large number of clinical trials to guide the treatment of recurrence tumor. Here we reported a case of radiotherapy with apatinib for the treatment of recurrent malignant phyllodes tumor of the breast.

Patient Concerns: A 58-year-old patient with massive breast mass was admitted to our hospital. Read More

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http://dx.doi.org/10.1097/MD.0000000000018808DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7220223PMC
January 2020
5.723 Impact Factor

Relative apparent diffusion coefficient (rADC) in breast lesions of uncertain malignant potential (B3 lesions) and pathologically proven breast carcinoma (B5 lesions) following breast biopsy.

Eur J Radiol 2020 Mar 28;124:108854. Epub 2020 Jan 28.

Institute of Oncology and Radiology of Serbia, Clinic for Radiology and Radiation Oncology, Dept. or Radiology, Dept. of Breast Imaging, School of Medicine, University of Belgrade, Belgrade, Serbia.

Purpose: To assess relative apparent diffusion coefficient (rADC) and ADC in B3 and B5 lesions in premenopausal female patients, added to standard morpho-dynamic breast contrast-enhanced MRI.

Methods: 104 patients with histologically confirmed B3 (N1 = 52) and matched B5 lesions (N2 = 52), were examined on MRI (1.5 T, full diagnostic protocol, diffusion weighted imaging - b50, b850) in a retrospective analysis following the IRB approval: Atypical ductal hyperplasia (ADH, n1 = 20), Flat epithelial atypia (FEA, n2 = 11), Classic lobular neoplasia (CLN, n3 = 8), Papillary lesion (PL, n4 = 6) and Phyllodes tumor (PT, n5 = 7). Read More

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http://dx.doi.org/10.1016/j.ejrad.2020.108854DOI Listing

Pediatric Malignant Phyllodes Tumors of the Breast: Characteristics and Outcomes Based on the Surveillance Epidemiology and End Results Database.

J Surg Res 2020 May 25;249:205-215. Epub 2020 Jan 25.

Department of Thyroid and Breast Surgery, Union Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Electronic address:

Background: Malignant phyllodes tumors of the breast are uncommon in women and rare in children. This study aimed to assess the differences in survival among five specific pathologic groups of breast malignancies and the differences between pediatric and adult breast phyllodes malignancy.

Materials And Methods: Using the Surveillance, Epidemiology, and End Results database, we collected data on 270 pediatric (aged ≤21 y) female breast malignant tumor patients and 2773 female malignant phyllodes tumor patients between 1976 and 2015. Read More

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http://dx.doi.org/10.1016/j.jss.2019.12.031DOI Listing

Surgical Margins and Adjuvant Therapies in Malignant Phyllodes Tumors of the Breast: A Multicenter Retrospective Study.

Ann Surg Oncol 2020 Jun 27;27(6):1818-1827. Epub 2020 Jan 27.

Department of Medical Oncology, Institut du Cancer Montpellier, Univ Montpellier, Montpellier, France.

Background: The optimal threshold of surgical margins for breast malignant phyllodes tumors (MPTs) and the impact of adjuvant chemotherapy and radiotherapy were investigated.

Patients And Methods: We conducted a multicenter nationwide retrospective study of all MPT cases with central pathological review within the French Sarcoma Group. Endpoints were local recurrence-free survival (LRFS), metastasis-free survival (MFS), and overall survival (OS) rates. Read More

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http://dx.doi.org/10.1245/s10434-020-08217-yDOI Listing

Fibroepithelial Lesions (FELs) of the Breast: Is Routine Excision Always Necessary?

World J Surg 2020 May;44(5):1552-1558

Department of Surgery, Weill Cornell Medical College, New York-Presbyterian Hospital, 420 East 70th St, Room 251, New York, NY, 10021, USA.

Background: When needle core biopsies (NCBs) of the breast reveal fibroepithelial lesions (FELs), excision is often performed to rule out a phyllodes tumor (PT), despite low malignancy rates. Consequently, the natural history of observed FELs is not well described. We analyzed the malignancy risk in excised FELs and the natural history of FELs undergoing active surveillance (AS). Read More

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http://dx.doi.org/10.1007/s00268-020-05385-6DOI Listing
May 2020
2.642 Impact Factor

Immunohistochemical expression of Ki-67, p53, and CD10 in phyllodes tumor and their correlation with its histological grade.

J Lab Physicians 2019 Oct-Dec;11(4):330-334

Department of Pathology, PGIMER and Dr. RML Hospital, New Delhi, India.

Context: Phyllodes tumors (PTs) are the fibroepithelial neoplasms of the breast. Histologically, PTs are divided into three subgroups according to their clinicopathological behavior: benign, borderline, and malignant. It is at times difficult to ascertain the grade of PT on morphological criteria alone, especially borderline PT may be at times difficult to distinguish from its benign or malignant counterparts. Read More

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http://dx.doi.org/10.4103/JLP.JLP_106_19DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6943865PMC
January 2020

Gaint phyllodes tumour with axillary & interpectoral lymph node metastasis; A rare presentation.

Int J Surg Case Rep 2020 26;66:350-355. Epub 2019 Dec 26.

Department of Surgical Oncology, King Fahad Medical City, Riyadh, Saudi Arabia.

Introduction: Phyllodes tumors are rare fibroepithelial neoplasms of the breast, account for less than 1 % of all breast neoplasms, lymph node metastasis is even rare and routine axillary dissection is not recommended. Approximately 20 % of patients with malignant phyllodes tumors develop distant metastasis.

Case Description: A 45 years old premenopausal female, presented with a huge right breast mass for 3 years. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.12.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6953703PMC
December 2019

Surgical margins for borderline and malignant phyllodes tumours.

Ann R Coll Surg Engl 2020 Mar 10;102(3):165-173. Epub 2020 Jan 10.

Oxford University Hospitals NHS Trust, , Oxford, UK.

Background: Phyllodes tumours represent less than 1% of all UK breast neoplasms. Histological features allow classification into benign, borderline or malignant, which has a significant impact on prognosis and recurrence. Currently, there is no consensus for the optimal surgical excision margin. Read More

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http://dx.doi.org/10.1308/rcsann.2019.0140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7027423PMC

Ultrasound-guided vacuum-assisted excisional biopsy to treat benign phyllodes tumors.

Breast 2020 Feb 18;49:242-245. Epub 2019 Dec 18.

Department of Ultrasound, Chinese People's Liberation Army General Hospital, 28 Fuxing Road, Beijing, 100853, China. Electronic address:

Purpose: To evaluate the value of ultrasound (US)-guided vacuum-assisted excisional biopsy (VAB) in treating benign phyllodes tumors (PTs) of the breasts and to investigate the lesion characteristics that could affect the local recurrence rate.

Patient And Methods: From December 2008 to February 2018, 93 patients with PTs diagnosed on histology underwent US-guided, 7-gauge VAB. The recurrence rate of benign PT and complications of VAB were evaluated on follow-up US every three to six months. Read More

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http://dx.doi.org/10.1016/j.breast.2019.12.008DOI Listing
February 2020