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Front Oncol 2022 9;12:875793. Epub 2022 Jun 9.

Graduate School, Dalian Medical University, Dalian, China.

Background: Primary osteosarcoma of the breast (POB) is an extremely aggressive and heterogeneous neoplasm that originates from nonepithelial elements of the mammary gland and accounts for fewer than 1% of breast cancers and fewer than 5% of all sarcomas.

Case Presentation: An 83-year-old Chinese woman went to our hospital because of a palpable mass she had had for 8 months in the left breast accompanied by persistent dull pain for 10 days. This mass was initially misdiagnosed as a degenerating fibroadenoma and was graded as probably benign (BI-RADS category 3) by ultrasonography (US) and computed tomography (CT) plain scan and contrast enhancement of chest. Read More

J Natl Compr Canc Netw 2022 Jun;20(6):691-722

28Moffitt Cancer Center.

The therapeutic options for patients with noninvasive or invasive breast cancer are complex and varied. These NCCN Clinical Practice Guidelines for Breast Cancer include recommendations for clinical management of patients with carcinoma in situ, invasive breast cancer, Paget disease, phyllodes tumor, inflammatory breast cancer, and management of breast cancer during pregnancy. The content featured in this issue focuses on the recommendations for overall management of ductal carcinoma in situ and the workup and locoregional management of early stage invasive breast cancer. Read More

Breast J 2022 31;2022:4474251. Epub 2022 Jan 31.

Department of Breast and Endocrine Surgery, Korea University Guro Hospital, Seoul, Republic of Korea.

Purpose: Phyllodes tumors (PTs) of the breast are rare fibroepithelial neoplasms, and factors associated with the recurrence of PTs are poorly understood. This study sought to identify clinicopathological factors associated with the recurrence of PTs.

Method: From January 2009 to December 2019, we identified 100 patients who underwent definitive surgery for PT. Read More

Case Rep Oncol 2022 Jan-Apr;15(1):455-461. Epub 2022 Apr 28.

Pathology Department, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates.

Solitary fibrous tumor (SFT) is an uncommon tumor of mesenchymal origin, which can arise at any anatomic location and can exhibit versatile histological features and a clinical course ranging from benign to frankly malignant. Lipomatous (fat-forming) SFT is a morphological variant of SFT characterized by an adipose tissue component. Breast SFT is an extremely rare clinical entity, and the literature review yielded only 28 previously reported cases. Read More

Front Endocrinol (Lausanne) 2022 26;13:871998. Epub 2022 May 26.

Department of Geriatrics, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.

A case of hypoglycemic coma caused by a giant borderline phyllodes tumor of the breast has been described. The patient, a 63-year-old woman, was admitted with recurrent unconsciousness. She had a giant breast tumor with decreased blood glucose, insulin, and C-peptide. Read More

Pathology 2022 Jun 9. Epub 2022 Jun 9.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. Electronic address:

Phyllodes tumour (PT) of breast is a rare biphasic neoplasm. Recent next generation sequencing analyses had revealed novel genetic alterations in PT but lacked a further characterisation of their relationship to different PT features and outcome. Here, using targeted sequencing, we examined a panel of 90 recurrently altered or cancer related genes in 88 PT samples (including 49 benign, 25 borderline and 14 malignant PT). Read More

Rom J Morphol Embryol 2021 Oct-Dec;62(4):1035-1044

Department of Surgery, University of Medicine and Pharmacy of Craiova, Romania;

Phyllodes tumors (PTs) are rare tumors of the breast, which encompass both stromal and epithelial components. The maximum incidence is in the fourth decade of life. Most of these tumors are benign, but about one third can be malignant acting as sarcomas. Read More

J Magn Reson Imaging 2022 Jun 3. Epub 2022 Jun 3.

Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China.

Background: Preoperative pathological grading assessment is important for patients with breast phyllodes tumors (PTs).

Purpose: To develop and validate a clinical-radiomics model based on multiparametric MRI and clinical information for the pretreatment differential diagnosis of PTs.

Study Type: Retrospective. Read More

Breast Cancer Res Treat 2022 May 31. Epub 2022 May 31.

Providence Breast Centre, Mount Saint Joseph Hospital, 3080 Prince Edward Street, Vancouver, BC, V5T 3N4, Canada.

Purpose: Fibroepithelial lesions (FEL) range from benign fibroadenoma (FA) to malignant phyllodes tumor (PT), but can be difficult to diagnose on core needle biopsy (CNB). This study assesses risk factors for phyllodes tumor (PT) and recurrence and whether a policy to excise FELs over 3 cm in size is justified.

Methods: Patients having surgery for FELs from 2009 to 2018 were identified. Read More

Ann Med Surg (Lond) 2022 May 29;77:103560. Epub 2022 Mar 29.

Surgical Oncology Department, Regional Oncology Center, Mohammed VI University Hospital, Oujda, Morocco.

Introduction: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract.

Presentation Of Case: 54-year-old woman with a history of phyllodes tumor of the left breast he patient was admitted to our hospital for management of retroperitoneal soft tissue tumor, attached to the fourth portion of the duodenum, opposite the head of the pancreas. The patient underwent a large excision of the tumor, the duodenojejunal flexure, and the third and fourth portions of the duodenum along with the head of the pancreas. Read More

Zhonghua Zhong Liu Za Zhi 2022 May;44(5):455-456

Department of General Surgery (Breast Surgery), the First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital), Jinan 250014, China.

Am J Clin Pathol 2022 May 15. Epub 2022 May 15.

Department of Pathology, University of Pittsburgh, UPMC Magee-Womens Hospital, Pittsburgh, PA, USA.

Objectives: Phyllodes tumors (PTs) are categorized by the World Health Organization (WHO) as benign, borderline, and malignant. Singapore General Hospital (SGH) nomogram is a recurrence risk assessment tool for PT, which uses cytologic atypia, mitosis, stromal overgrowth, and the surgical margin status. We studied the prognostic significance of WHO classification and its correlation to the SGH nomogram. Read More

J Breast Cancer 2022 Apr;25(2):117-130

Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Purpose: Knowing the distinction between benign and borderline/malignant phyllodes tumors (PTs) can help in the surgical treatment course. Herein, we investigated the value of magnetic resonance imaging-based texture analysis (MRI-TA) in differentiating between benign and borderline/malignant PTs.

Methods: Forty-three women with 44 histologically proven PTs underwent breast MRI before surgery and were classified into benign (n = 26) and borderline/malignant groups (n = 18 [15 borderline, 3 malignant]). Read More

Niger J Clin Pract 2022 Apr;25(4):425-431

Department of General Surgery, Seyhan Goverment Hospital Seyhan, Adana, Turkey.

Background And Aim: Phyllodes tumors (PT) are rare biphasic breast tumors containing stromal mesenchyme and epithelial components. It was classified as benign, borderline, and malignant by the World Health Organization (WHO). Although there is no certainty about the size of the desired margin in the surgery to be applied, a tumor-free area of 1 cm is often targeted. Read More

Diagn Cytopathol 2022 Apr 16. Epub 2022 Apr 16.

Department of Endocrine Surgery, King George's Medical University, Lucknow, India.

Objective: This study has been designed in an effort to identify the clinico-radiological and cytological features that could effectively help in differentiating cellular fibroadenoma (CFA) and phyllodes tumors (PT), which have several overlapping characteristics.

Method: Histologically proven cases of CFA and PT were reviewed. Cytological features were assessed and categorized. Read More

Pathologica 2022 Apr 13;114(2):111-120. Epub 2022 Apr 13.

Division of Anatomic Pathology and Histology Catholic University Rome, Italy.

Phyllodes tumors (PT) are fibroepithelial neoplasms of the breast showing a peculiar leaf-like appearance. They account for 0.3 to 1% of all primary breast tumors and 2. Read More

Breast Dis 2022 ;41(1):221-228

Women's Imaging Unit, University Hospital of Strasbourg, Hautepierre Hospital, Strasbourg Cedex, France.

Objective: Preoperative diagnosis of phyllodes tumor (PT) is challenging, core-needle biopsy (CNB) has a significant rate of understaging, resulting in suboptimal surgical planification. We hypothesized that the association of imaging data to CNB would improve preoperative diagnostic accuracy compared to biopsy alone.

Methods: In this retrospective pilot study, we included 59 phyllodes tumor with available preoperative imaging, CNB and surgical specimen pathology. Read More

Asian J Surg 2022 Mar 31. Epub 2022 Mar 31.

Department of Gastrointestinal Surgery, The Second Affliated Hospital of Fujian Medical University, No. 950 Donghai Street, Fengze District, Quanzhou, 362000, Fujian Province, China. Electronic address:

NPJ Breast Cancer 2022 Apr 1;8(1):44. Epub 2022 Apr 1.

Duke-NUS Medical School, Singapore, Singapore.

Malignant phyllodes tumors (PT) are rare aggressive fibroepithelial neoplasms with high metastatic potential and lack effective therapy. We established a patient-derived xenograft (PDX) and cell line model (designated MPT-S1) of malignant PT which demonstrated clinical response to pazopanib. Whole exome sequencing identified somatic mutations in TP53, RB1, MED12, and KMT2D. Read More

Plast Reconstr Surg Glob Open 2022 Mar 25;10(3):e4188. Epub 2022 Mar 25.

Department of Plastic & Reconstructive Surgery, Naval Medical Center Portsmouth, Va.

Phyllodes tumors are rare fibroepithelial breast tumors representing less than 1% of all breast malignancies, with an extremely uncommon presence in the pediatric population. Although prognosis is favorable following excision given their indolent course, they often grow rapidly and frequently recur. As such, they can present unique oncologic and reconstructive challenges. Read More

PLoS One 2022 24;17(3):e0265952. Epub 2022 Mar 24.

Department of Ultrasound, Sichuan Cancer Hospital Institute, Sichuan Cancer Center, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Objective: To evaluate ultrasound characteristics in the prediction of malignant and benign phyllodes tumor of the breast (PTB) by using Logistic regression analysis.

Methods: 79 lesions diagnosed as PTB by pathology were analyzed retrospectively. The ultrasound features of PTB were recorded and compared between benign and malignant tumors by using single factor and multiple stepwise Logistic regression analysis. Read More

Cureus 2022 Mar 16;14(3):e23225. Epub 2022 Mar 16.

General Surgery, All India Institute of Medical Sciences, Bhopal, Bhopal, IND.

Phyllodes tumor (PT) is a rare benign tumor of the breast with a propensity to recur and metastasize. Ductal carcinoma in situ (DCIS) within PT is an extremely rare finding and is usually diagnosed postoperatively. We present a case of a 36-year-old female with a recurrent lump in her left breast diagnosed as a benign PT. Read More

Surg Pathol Clin 2022 Mar 31;15(1):77-93. Epub 2022 Jan 31.

Department of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston TX 77030-4009, USA.

Most of the high-grade spindle cell lesions of the breast are malignant phyllodes tumors (MPTs), spindle cell carcinomas (SpCCs), and matrix-producing metaplastic breast carcinomas (MP-MBCs). MPTs have neoplastic spindle stromal cells and a classic leaf-like architecture with subepithelial stromal condensation. MPTs are often positive for CD34, CD117, and bcl-2 and are associated with MED12, TERT, and RARA mutations. Read More

World J Clin Cases 2022 Feb;10(4):1432-1440

Department of Ultrasound, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen 518035, Guangdong Province, China.

Background: Inflammatory myofibroblastic tumors (IMTs) are defined as tumors composed of differentiated myofibroblastic spindle cells, usually accompanied by numerous plasma cells and lymphocytes, and classified as intermediate (occasionally metastatic) by the World Health Organization. Its pathogenesis and biological behavior have not yet been elucidated. Breast IMT is extremely rare, and prosthesis implantation combined with IMT has not been reported. Read More

Front Oncol 2022 8;12:800484. Epub 2022 Feb 8.

The Comprehensive Cancer Centre of Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.

Some of the mutant peptides produced by gene mutation transcription and translation have the ability to induce specific T cells, which are called new antigens. Neoantigen-based peptide, DNA, RNA, and dendritic cell vaccines have been used in the clinic. In this paper, we describe a lung metastasis of a phyllodes tumor patient demonstrating pathological complete response following treatment containing personalized multi-epitope peptide neoantigen nano-vaccine. Read More

J Surg Oncol 2022 May 18;125(6):947-957. Epub 2022 Feb 18.

Duke Cancer Institute, Duke University, Durham, North Carolina, USA.

Background: Malignant phyllodes (MP) and primary breast sarcomas (PBS) are rare neoplasms with overlapping histopathologic features. We compared overall survival (OS) and estimated the association of surgery and therapies with OS.

Methods: We utilized the National Cancer Database (2004-2016). Read More

Radiol Case Rep 2022 Apr 3;17(4):1110-1114. Epub 2022 Feb 3.

Department of Pathology, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Accessory breast tissue is an anatomical variation which occurs during embryogenic development. It appears most frequently at the axilla. Benign and malignant processes in general breast tissue can occur in accessory breast tissue. Read More

Breast Cancer Res Treat 2022 Apr 12;192(3):603-610. Epub 2022 Feb 12.

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.

Background: We aimed at investigating outcome of systemic treatments in advanced breast PT.

Methods: All cases of advanced breast PT treated with systemic treatments from 1999 to 2019, in one of the referral sarcoma centers involved in the study, were retrospectively reviewed.

Results: 56 female patients were identified. Read More

Mod Pathol 2022 Feb 11. Epub 2022 Feb 11.

Department of Anatomical Pathology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

NTRK-rearranged mesenchymal neoplasms mostly affect the soft tissues of pediatric patients. Given the responsiveness to selective NTRK inhibitors, it remains critical to identify those ultra-rare cases occurring in the viscera of adults. In five females and two males aged 18-53 years, we characterized visceral mesenchymal tumors harboring TPM3-NTRK1 [uterine cervix (N = 2), pleura, prostate], LMNA-NTRK1 (lung), SQSTM1-NTRK3 (heart), and NTRK3 rearrangement with unknown fusion partner (colon/mesocolon) with RNA sequencing, FISH, RT-PCR, and immunohistochemistry. Read More

Int J Surg Case Rep 2022 Feb 2;91:106804. Epub 2022 Feb 2.

Division of Oncology and Surgery, Department of Surgery, Kaohsiung Medical University Chung-Ho Memorial Hospital, No.100, Tzyou 1st Rd., Sanmin Dist., Kaohsiung City 80756, Taiwan. Electronic address:

Introduction And Importance: Phyllodes tumors (PT) account for approximately 1% of all breast tumors. The coexistence of phyllodes tumor and invasive lobular carcinoma in the ipsilateral breast is extremely rare with fewer than six cases reported worldwide in the last 20 years. We hereby present the first in Taiwan. Read More