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Gan To Kagaku Ryoho 2018 Dec;45(13):2429-2431

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

A 72-year-old woman visited our hospital with the chief complaint of a mass in the right breast. Breast ultrasonography revealed a hypoechoic area with a distinct border in the right breast. A core needle biopsy showed the proliferation of spindle cells in the stroma, and she was diagnosed with stromal sarcoma or malignant phyllodes tumor. Read More

Gan To Kagaku Ryoho 2018 Dec;45(13):1854-1856

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.

A 33-year-old woman underwent resection of a right breast mass, which was diagnosed as a fibroadenoma 15 years ago. Ten years later, a right breast mass appeared again, and it was diagnosed as a fibroadenoma based on core needle biopsy. After observation for a while, the mass increased in size, and she underwent resection of the tumor, which was diagnosed as a borderline-malignant phyllodes tumor. Read More

F1000Res 2018 22;7:359. Epub 2018 Mar 22.

Human Genetics, University of Bremen, Bremen, D-28359 , Germany.

Mediator Complex Subunit 12 (MED12) is part of the transcriptional preinitiation machinery. Mutations of its gene predominantly occur in two types of highly frequent benign tumors, uterine leiomyomas and fibroadenomas of the breast, where they apparently act as driver mutations. Nevertheless, their presence is not restricted to benign tumors having been found at considerable frequencies in uterine leiomyosarcomas, malignant phyllodes tumors, and chronic lymphocytic leukemia also. Read More

Ann Surg Oncol 2019 Jan 7. Epub 2019 Jan 7.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Background: This systematic review and meta-analysis aimed to investigate local recurrence (LR) rates among the three grades (benign, borderline, and malignant) of phyllodes tumors (PTs). The study also assessed various risk factors for LR.

Methods: Electronic articles published between 1 January 1995 and 31 May 2018, were searched and critically appraised. Read More

Ann Clin Lab Sci 2018 Nov;48(6):770-775

Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center McGovern Medical School, Houston, TX, USA.

Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. It is unclear whether this tumor belongs to the spectrum of phyllodes tumor or is a separate entity. We present a 57-year-old woman with a 3. Read More

Medicine (Baltimore) 2018 Dec;97(52):e13767

Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China.

Rationale: Phyllodes tumors (PTs) of the breast are rare biphasic fibroepithelial neoplasms which usually present with unilateral palpable breast lumps. Here we reported a case of borderline PTs with multifocal intraductal lesions whose primary clinical manifestation was nipple discharge.

Patient Concerns: A rare case of PT with nipple discharge in a 26-year-old young lady accepted a wide local excision on her left breast, and the pathological examination turned out to be a malignant phyllodes tumor. Read More

In Vivo 2019 Jan-Feb;33(1):263-269

Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background/aim: In this study, the treatment outcome and risk factors for recurrence in patients undergoing surgery with or without adjuvant radiotherapy (RT) for malignant phyllodes tumors of the breast (MPTB) were analyzed.

Patients And Methods: Forty-three patients (61.4%) underwent breast-conserving surgery (BCS) and 27 (38. Read More

Int J Surg Case Rep 2018 1;53:490-494. Epub 2018 Nov 1.

University of Biruni, Faculty of Medicine, Department of Pathology, Protokol Yolu No: 45, 10. Yıl Cd., 34010 Zeytinburnu, İstanbul, Turkey. Electronic address:

Introduction: The stromal component of Phyllodes tumors represents the neoplastic portion of the lesion. A variety of associated malignancies can arise from PTs, with its dual population of cells.

Presentation Of Case: We share a very rare case of "borderline"breast phillodes tumour with a 75% liposarcoma component. Read More

Clin Case Rep 2018 Dec 6;6(12):2498-2503. Epub 2018 Nov 6.

Division of Surgical Oncology The James Cancer Hospital at The Ohio State University Columbus Ohio.

This unusual case of concurrent eccrine adenocarcinoma, phyllodes tumor, and multinodular goiter serves to alert the oncologic community to the high prevalence of second cancers after childhood radiotherapy. Increased surveillance and index of suspicion are recommended to successfully diagnose and treat second primary cancers in this vulnerable population. Read More

Indian J Surg Oncol 2018 Dec 30;9(4):578-580. Epub 2018 Jul 30.

Department of Surgical Oncology, Bombay Hospital, Bombay hospital Marg, Marine Drive, Mumbai, Maharashtra 400020 India.

Extraskeletal osteosarcomas are extremely rare and account for < 1% of the soft tissue sarcomas. Most common site is in soft tissues of the lower extremities. Primary osteosarcomas of the breast are extremely rare and only a few cases have been reported in literature. Read More

Breast 2019 Feb 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

Tumour Biol 2018 Nov;40(11):1010428318815032

1 Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea.

Phyllodes tumors are rare biphasic breast tumors with the potential for both local recurrence and distant metastasis. The aberrant expression of B7-H3 and B7-H4 B7 molecules could be potential targets for future development of immunotherapeutic approaches. This work was undertaken to evaluate the expression of B7-H3 and B7-H4 in phyllodes tumors and assess the association with the grade and clinical behavior of phyllodes tumors. Read More

AJR Am J Roentgenol 2019 Feb 26;212(2):450-455. Epub 2018 Nov 26.

1 Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390.

Objective: The purpose of this study is to describe our experience with pathologically proven breast masses at a tertiary care pediatric institution, review published management strategies, and propose new management recommendations for the pediatric population.

Materials And Methods: All pediatric breast ultrasound examinations performed at a dedicated pediatric facility over a 4-year period were reviewed. Maximum measurements of solid masses with features of a fibroadenoma were recorded. Read More

Clin Breast Cancer 2019 Feb 1;19(1):e1-e6. Epub 2018 Nov 1.

Breast Center, University Hospital Basel, Basel, Switzerland.

Onco Targets Ther 2018 2;11:7787-7793. Epub 2018 Nov 2.

Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, China,

Background: Phyllodes tumor (PT) is a rare breast fibroepithelial biphasic tumor composed of stromal and epithelial components. The patients suffering from this disease present with a large, round, mobile, fast-growing lump, and the giant PT of more than 10 cm in diameter is so uncommon. Surgery is regarded as the primary treatment, but curative efficiency of adjuvant chemotherapy and radiotherapy is so indefinite. Read More

Ann Med Surg (Lond) 2018 Dec 2;36:113-117. Epub 2018 Nov 2.

Department of Dermatology, Tribhuvan University Teaching Hospital, Nepal.

Background: Phyllodes tumors are spectrum of tumors ranging from benign to malignant. Malignant spectrum pose a management challenge for clinicians due to high risks of recurrence and metastasis. Malignant phyllodes tumor with brain, lung and adrenal metastases at the same time is rare. Read More

Histopathology 2018 Nov 1. Epub 2018 Nov 1.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Aims: Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms with the potential to recur and metastasise. Apart from histological grading, the expression of biological markers and its relationship with tumour behaviour have been topics of interest. The phosphatidylinositol 3-kinase (PI3K)-AKT pathway regulates diverse biological functions, and is one of the most frequently deregulated pathways in cancers. Read More

Aesthet Surg J 2018 Oct 29. Epub 2018 Oct 29.

Department of Plastic, Reconstructive, and Aesthetic Surgery, Dokuz Eylul University, Izmir, Turkey.

Background: Reduction mammaplasty (RM) is one of the most common plastic surgery procedures. Despite its cost, the total number of RM procedures continues to increase every year.

Objectives: The purpose of this study is to review the prevalence of benign and malignant breast lesions among women who live in Aegean region of Turkey, based on our university hospital's records and to compare our results with those in the literature. Read More

Acta Cytol 2018 Oct 26:1-5. Epub 2018 Oct 26.

Objective: Phyllodes tumors are fibroepithelial breast lesions with many cytological and histopathological similarities to fibroadenomas. The aim of this study was to investigate cytological findings in benign phyllodes tumors.

Study Design: Seventy-six histologically proven cases of benign phyllodes tumors were selected from 1982 to 2017. Read More

Med J Malaysia 2018 Oct;73(5):297-300

Hospital Queen Elizabeth 2, Breast and Endocrine Department, Kota Kinabalu, Sabah, Malaysia.

Background: Malignant phyllodes tumors of the breast are uncommon fibroepithelial breast tumors with diverse biological behavior. Our study aim is to share our experience in treating patients with malignant phyllodes presenting to our center.

Patients And Methods: A total of 11 cases of malignant phyllodes were retrospectively reviewed between Nov 2014 and Oct 2017. Read More

Breast J 2018 Nov 22;24(6):1076-1077. Epub 2018 Oct 22.

Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

J Int Med Res 2018 Oct 14:300060518803530. Epub 2018 Oct 14.

1 Hematology and Oncology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Objective This study was performed to determine the subtypes of phyllodes tumor (PT) in patients at a single tertiary healthcare center in Lebanon and to describe their characteristics along with a review of the literature. Methods This single-institution retrospective cohort study included all cases of PT of the breast treated at the American University of Beirut Medical Center from 1 January 2010 to 31 December 2014. The patients' demographic data, tumor characteristics, treatment data, and pathology reports were analyzed. Read More

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):577-579

Department of Histopathology, Apollo Cancer Institutes, Chennai, Tamil Nadu, India.

Pure mesenchymal sarcomas and phyllodes tumor with sarcomatous differentiation of the breast are rare tumors. Primary breast sarcomas are a heterogenous group of neoplasms which include malignant fibrous histiocytoma, fibrosarcoma, angiosarcoma, leiomyosarcoma, osteosarcoma, rhabdomyosarcoma, and liposarcoma. Sarcomatous differentiation in phyllodes tumor is seen in the form of angiosarcoma, chondrosarcoma, leiomyosarcoma, osteosarcoma, rhabdomyosarcoma, and liposarcoma. Read More

Indian J Surg Oncol 2018 Sep 18;9(3):402-406. Epub 2018 May 18.

M.S.Ramaiah Medical College, MSR Nagar, Gokula post, Bangalore, 560054 India.

The aim of the current study was to assess the incidence and varying clinical presentations of benign breast lumps in adolescent age group in a Tertiary care Medical College Hospital. This was a prospective, observational study of 6-year duration (2011 to 2017) conducted in a Medical College, South India. All adolescent age group patients visiting the outpatient department (OPD) with complaints of breast lump were enrolled into the study. Read More

Indian J Surg Oncol 2018 Sep 16;9(3):387-390. Epub 2018 Apr 16.

3Department of Pathology, ESIC Medical College, Faridabad, Haryana India.

Primary malignant spindle cell tumors are rare constituting 1.0% of breast malignancies. Spindle cell lesions occurring in soft tissues can occur in breast with overlapping morphologies. Read More

Eur J Radiol Open 2018 24;5:165-170. Epub 2018 Sep 24.

Institute for Diagnostic and Interventional Radiology, University Hospital of Zurich, Switzerland.

Purpose: To evaluate the accuracy of a deep learning software (DLS) in the discrimination between phyllodes tumors (PT) and fibroadenomas (FA).

Methods: In this IRB-approved, retrospective, single-center study, we collected all ultrasound images of histologically secured PT (n = 11, 36 images) and a random control group with FA (n = 15, 50 images). The images were analyzed with a DLS designed for industrial grade image analysis, with 33 images withheld from training for validation purposes. Read More

Breast J 2018 Nov 24;24(6):1035-1037. Epub 2018 Sep 24.

Radiology Department, Lucus Augusti Hospital, Lugo, Spain.

We aimed to evaluate the efficacy of vacuum assisted percutaneous excision in the treatment of benign phyllodes tumors of the breast. From 2007 to 2016, a total of 160 benign fibroepithelial nodules were percutaneously removed in our department. Ultrasonographic follow-up was performed 12 months after the procedure to assess recurrence. Read More

Acta Cytol 2018 24;62(5-6):450-455. Epub 2018 Sep 24.

Pathology Department, Faculdade de Medicina da Universidade do Porto, Porto,

Background: The presence of highly cellular stromal fragments in breast fine needle aspirates (FNA) suggests some classical differential diagnoses such as cellular fibroadenoma, phyllodes tumour (PT), metaplastic carcinomas, and some mesenchymal/myoepithelial proliferations. The other components of the smears can help in the differential diagnosis, but the presence of a low-grade epithelial proliferation does not always represent a fibro-epithelial lesion as we demonstrate in these two cases.

Cases: We discuss two cases of breast FNA, previously presented in a slide seminar at the 29th European Congress of Pathology in Amsterdam, where the common cytological finding was the presence of stromal cellular fragments together with an epithelial component. Read More

J Cancer Res Ther 2018 Jul-Sep;14(5):1138-1141

Department of Histopathology and Cytopathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Phyllodes tumor (PT) is an extremely rare tumor of the breast of mixed mesenchymal and epithelial origin. It may pursue a benign or malignant evolution with distant metastases in the latter case in 3-12% of patients. The most common sites of metastases are the lungs and bones. Read More

J Cancer Res Ther 2018 Jul-Sep;14(5):1054-1058

Department of Radiation Oncology, Gandhi Medical College, Bhopal, Madhya Pradesh, India.

Introduction: Cystosarcoma phyllodes of the breast, an uncommon sarcoma found primarily in women of the age group of 35-55 years, constitutes <1% of all breast neoplasms. These tumors are resistant to chemotherapy and hormonal therapies and often recur aggressively after initial surgery. Limited research is available about the role and effectiveness of adjuvant radiotherapy in reducing recurrences. Read More

Eur J Surg Oncol 2018 11 18;44(11):1743-1749. Epub 2018 Aug 18.

Service de Gynécologie, CHU de Rennes, Hôpital sud, 16 Bd de Bulgarie, 35000, Rennes, France; Service de Sénologie, CRLC Eugène Marquis, Avenue de Bataille Flandres Dunkerque, 35000, Rennes, France; INSERM 1242, Chemistry, Oncogenesis, Stress and Signaling, Rennes, France. Electronic address:

Objective: To assess prognostic factors of recurrence of phyllodes tumors (PT) of the breast.

Methods: We performed a retrospective, multicentric cohort study, including all patients who underwent breast surgery for grade 1 (benign), 2 (borderline) or 3 (malignant) PT between 2000 and 2016 in five tertiary University hospitals, diagnosed according to World Health Organisation classification.

Results: 230 patients were included: 144 (63%), 60 (26%) and 26 (11%) with grade 1, 2 and 3 PT, respectively. Read More

Anticancer Res 2018 Sep;38(9):5481-5487

Department of Diagnostic Pathology, Gangnam CHA Medical Center, College of Medicine, CHA University, Seoul, Republic of Korea.

Background/aim: Recently, the development of ultrasonography (US)-guided vacuum-assisted breast biopsy (VABB) has enabled the excision of benign breast tumors with normal surrounding breast tissues; thus, complete excision is possible without residual tumor tissue. We sought to identify the clinicopathological characteristics and recurrence rates of benign phyllodes tumors diagnosed by US-guided VABB.

Patients And Methods: Data from 11,221 US-guided VABBs performed at the Gangnam Cha Medical Center over 12 years were analyzed. Read More

Korean J Radiol 2018 Sep-Oct;19(5):978-991. Epub 2018 Aug 6.

Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.

Pediatric breast disease is uncommon, and primary breast carcinoma in children is extremely rare. Therefore, the approach used to address breast lesions in pediatric patients differs from that in adults in many ways. Knowledge of the normal imaging features at various stages of development and the characteristics of breast disease in the pediatric population can help the radiologist to make confident diagnoses and manage patients appropriately. Read More

Acad Pathol 2018 Jan-Dec;5:2374289518790926. Epub 2018 Aug 24.

West Virginia University Health Sciences Center, Morgantown, WV, USA.

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals. Read More

Gulf J Oncolog 2018 May;1(27):64-69

Pathology Department, Hindurao Hospital and NDMC Medical college, New Delhi, India.

Phyllodes tumor is a rare fibroepithelial neoplasm of the breast and constitutes 0.3-0.5% of all breast tumors. Read More

Hum Pathol 2018 Dec 17;82:289-296. Epub 2018 Aug 17.

Department of Epidemiology, University of California, Irvine, CA 92697-7550, USA.

The purpose of this study was to determine the distribution of and potential significance of laminin 332 (LM332) in breast cancer. Specimens from a population-based cohort (N = 297) from 1994 to 1995 were stained for estrogen receptor (ER), progesterone receptor (PgR), HER2 and the LM332 β3 chain. Seventy-five tumors were LM332-positive and 222 were negative. Read More

Medicine (Baltimore) 2018 Aug;97(31):e11412

Breast Unit, Department of Surgery.

Phyllodes tumor or cystosarcoma phyllodes is a rare fibroepithelial neoplasm which arises from the periductal stroma of the breast. They are classified as benign, borderline, and malignant based on the histologic features. However, all phyllodes tumor (PT) subtypes are regarded as having malignant potential and correct diagnosis is important for surgical management and optimal care. Read More

Case Rep Oncol Med 2018 27;2018:6491675. Epub 2018 Jun 27.

Pathology Services Division, Johns Hopkins Aramco Healthcare, Dhahran, Saudi Arabia.

Phyllodes tumor (PT) is a rare tumor of the breast accounting for approximately 1% of all breast neoplasms. In 1838, J. Muller coined the term "cystosarcoma phyllodes" based on the leaf-like projections of the tumor extending into the cystic spaces and sarcomatous stromal growth. Read More

World J Surg Oncol 2018 Jul 24;16(1):153. Epub 2018 Jul 24.

Department of General Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, 215006, China.

Background: The purpose of this study was to assess the effectiveness and safety in patients with benign phyllodes after performing local excision and following with intra-operative breast flap reconstruction.

Methods: Patients (n = 32) with eligible breast cystosarcoma phyllodes underwent wide local excision followed by intra-operative breast flap reconstruction. Primary outcome measures included average operative time, length of in-hospital stay, postoperative recurrence, and intra-operative and postoperative complications. Read More

Electron Physician 2018 Jun 25;10(6):6951-6955. Epub 2018 Jun 25.

Associate Professor of Surgical Oncology, Department of Surgery, Faculty of Medicine, University of Tabuk, Saudi Arabia.

Phyllodes tumor is a benign breast cancer with a malignant potential. It is very rare in Saudi Arabia and also rare around the world. Malignant phyllodes tumors originate from the connective tissue of the breast, so they are histologically sarcomas. Read More

Pak J Med Sci 2018 May-Jun;34(3):770-771

Prof. Dr. Altaf Hussain Rathore, FRCS. Retired Professor of Surgery, Punjab Medical College, Faisalabad, Pakistan.

A 25 years old unmarried woman was operated for a huge fungating tumor of right breast, proved to be a benign phyllodes tumor by preoperative and post-operative biopsy by two different renowned histopathology laboratories. Simple mastectomy with excision of wide margin of skin and pectoral major was done. She is followed up for 10 months; she has a good scar and no sign of any secondary so far. Read More

Breast J 2018 Nov 22;24(6):1062-1063. Epub 2018 Jul 22.

Department of Pathology, Inha University Hospital, Incheon, Korea.

Ann Diagn Pathol 2018 Aug 10;35:85-91. Epub 2018 Jan 10.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, United States. Electronic address:

Some fibroepithelial lesions (FEL) of the breast are difficult to classify as cellular fibroadenoma (CFA) or benign phyllodes tumor (BPT) due to overlapping histologic features. This indeterminate group is histologically characterized by prominent stromal cellularity, mild atypia, and mitotic activity. The local recurrence potential of cellular FEL (CFEL) has been insufficiently studied. Read More

Perm J 2018 07;22

Oncosurgeon at the University College of Medical Sciences and Guru Teg Bahadur Hospital in Shahdara, Delhi, India.

Introduction: Local treatment of metastatic cystosarcoma phyllodes is classically viewed with skepticism because it does not provide survival benefit. When these advanced tumors ulcerate, they reduce quality of life dramatically because of associated pain, infection, malodor, massive discharge, and bleeding.

Case Presentations: Two patients with metastatic cystosarcoma phyllodes presented to our hospital with recurrent disease featuring foul-smelling, ulcerated chest wall masses that caused physical pain and social exclusion. Read More

Ann Surg Oncol 2018 Oct 9;25(10):3088-3095. Epub 2018 Jul 9.

Department of Surgery, Division of Surgical Oncology, Loma Linda University School of Medicine, Loma Linda, CA, USA.

Background: In 2012, the World Health Organization (WHO) released diagnostic criteria for grading phyllodes tumors based on histologic features. This study sought to examine the application of the WHO criteria and the changing epidemiology of fibroepithelial tumors.

Methods: A retrospective review of surgically excised fibroepithelial lesions from 2007 to 2017 at a single tertiary care institution was conducted. Read More

Breast Cancer 2018 Nov 27;25(6):736-741. Epub 2018 Jun 27.

Departments of Breast Surgical Oncology, St. Luke's International Hospital, 9-1 Akashi-cho, Chuo-ku, Tokyo, 104-8560, Japan.

Background: This study aimed to assess their characteristics and clinical course of each histologic type of the behavior of phyllodes tumor (PT).

Methods: We retrospectively reviewed 124 patients with PTs who underwent surgical treatment from 2003 to 2011. PTs were classified as benign, borderline, and malignant using surgical specimens. Read More

BMJ Case Rep 2018 Jun 17;2018. Epub 2018 Jun 17.

Department of Pathology, University of the Philippines Manila, Manila, Philippines.

We present a rare and interesting case of a 35-year-old woman who initially underwent an uneventful wide excision for a 13 cm left benign phyllodes tumour. She then noted a slowly growing left thyroid nodule 8 months postsurgery which on thyroidectomy 4 years later was shown to be a 6.9cm isolated thyroid metastasis from the phyllodes tumour. Read More

J Surg Res 2018 Aug 12;228:247-252. Epub 2018 Apr 12.

Division of Pediatric Surgery, University of Texas Southwestern/Children's Health, Dallas, Texas. Electronic address:

Background: Pediatric breast masses can be a diagnostic challenge. Nearly all are benign, but there is no consensus on which should be removed. We hypothesized that children with asymptomatic breast lesions can be safely managed nonoperatively. Read More

Breast Cancer Res Treat 2018 Sep 28;171(2):335-344. Epub 2018 May 28.

Department of Radiation Oncology, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, Korea.

Purpose: To identify risk factors for local recurrence (LR) and investigate roles of adjuvant local therapy for malignant and borderline phyllodes tumors of the breast.

Methods: From 1981 to 2014, 362 patients with malignant (n = 235) and borderline (n = 127) phyllodes tumors were treated by breast-conserving surgery (BCS) or total mastectomy (TM) at 10 centers. Thirty-one patients received adjuvant radiation therapy (RT), and those who received adjuvant chemotherapy were excluded from the study. Read More