2,209 results match your criteria Cystosarcoma Phyllodes


Adjuvant radiotherapy and chemotherapy for patients with breast phyllodes tumors: a systematic review and meta-analysis.

BMC Cancer 2019 Apr 23;19(1):372. Epub 2019 Apr 23.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, People's Republic of China.

Background: As the efficacy of radiotherapy and chemotherapy for treatment of phyllodes tumors (PTs) remains unclear, this study aimed to review all available data and evaluate the roles of radiotherapy and chemotherapy in PT treatment.

Methods: We performed a comprehensive search of databases, including PubMed, Web of Science and the Cochrane Library. The outcomes of interest included the local recurrence (LR) rate, metastasis rate, disease-free survival rate and overall survival rate. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5585-5DOI Listing
April 2019
1 Read

Giant malignant phyllodes tumor with metastasis to the brain.

Proc (Bayl Univ Med Cent) 2019 Jan 15;32(1):116-118. Epub 2019 Jan 15.

Texas A&M Health Sciences CenterDallasTexas.

We present the case of a 32-year-old African American woman with a giant malignant phyllodes tumor that metastasized to the lungs and subsequently the brain. Her treatment included six cycles of adjuvant therapy with AIM (Adriamycin, ifosfamide, and mesna) followed by therapy with gemcitabine and docetaxel. A grand mal seizure led to discovery of a 6 × 5 × 5 cm brain mass which was resected. Read More

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http://dx.doi.org/10.1080/08998280.2018.1521207DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442793PMC
January 2019
3 Reads

Phyllodes tumor with a benign heterologous osseous component: a diagnostic challenge.

APMIS 2019 Mar 22. Epub 2019 Mar 22.

Department of Pathology, Copenhagen University Hospital, Rigshospitalet, København Ø, Denmark.

Phyllodes tumors (PTs) are rare fibroepithelial neoplasms of the breast and constitute 0.3-1% of all primary breast tumors. They should be characterized in to a benign, borderline or malignant category based on a combination of histological features. Read More

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http://dx.doi.org/10.1111/apm.12949DOI Listing
March 2019
2 Reads

Malignant Phyllodes Tumors of the Breast: Association Between Race, Clinical Features, and Outcomes.

J Surg Res 2019 Mar 18;239:278-283. Epub 2019 Mar 18.

Department of Surgery, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania. Electronic address:

Background: We sought to investigate associations between race, clinical characteristics, and outcomes among patients with malignant phyllodes of the breast.

Methods: Malignant phyllodes cases were identified using Surveillance Epidemiology and End Results database. We used chi-square tests to compare characteristics between racial groups and multinomial logistic regression to calculate relative risk ratios (RRR) and 95% confidence intervals (CI) comparing the likelihood of having particular characteristics by race. Read More

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http://dx.doi.org/10.1016/j.jss.2019.01.054DOI Listing
March 2019
1 Read

Breast phyllodes tumors recruit and repolarize tumor-associated macrophages via secreting CCL5 to promote malignant progression which can be inhibited by CCR5 inhibition Therapy.

Clin Cancer Res 2019 Mar 19. Epub 2019 Mar 19.

Breast Tumor Center, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University.

Purpose: Our previous studies have shown that the high density of tumor associated macrophage (TAM) plays an important role in the malignant progression of PTs. However, the mechanism by which TAMs are recruited and repolarized by PTs to drive the malignant progression remains unclear.

Experimental Design: The primary PT cells and TAMs were isolated from the human breast phyllodes tumor tissues for in vitro and in vivo experimens. Read More

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3421DOI Listing
March 2019
1 Read

Malignant Phyllodes Tumor Recurrence in the Pleural Cavity via the Deep Inferior Epigastric Perforator Flap and Internal Mammary Vessel Bundle: A Case Report.

Ann Plast Surg 2019 Mar 13. Epub 2019 Mar 13.

Division of General Surgery, Department of Surgery, Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan.

We report a rare case that after rapid recurrence there was pathological transition from a fibroadenoma and benign phyllodes tumor to borderline and malignant phyllodes tumor. Another rare finding included tumor dissemination in the pleural cavity via reconstructed deep inferior epigastric perforator flap edge and internal mammary vessel bundle. Hence, we eliminated the use of internal mammary vessel bundle as the recipient vessel for free-flap reconstruction to avoid recurrence in the pleural cavity. Read More

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http://Insights.ovid.com/crossref?an=00000637-900000000-9704
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http://dx.doi.org/10.1097/SAP.0000000000001795DOI Listing
March 2019
4 Reads

Malignant phyllodes tumor of the breast with liposarcomatous differentiation: A case report with imaging findings.

Radiol Case Rep 2019 May 22;14(5):531-534. Epub 2019 Feb 22.

Department of Radiology, Inje University, Ilsan Paik Hospital, 2240 Daehwa-dong, Ilsan Seo-gu, Goyang-si, Gyeonggi-do, Republic of Korea.

Phyllodes tumors are rare neoplasms that account for 2.5% of all fibroepithelial lesions, and 10%-20% exhibit malignant transformation. Malignant transformation often occurs in the form of stroma, and usually shows fibrosarcomatous differentiation. Read More

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http://dx.doi.org/10.1016/j.radcr.2019.02.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389548PMC
May 2019
4 Reads

Cytologic diagnosis of metastatic malignant phyllodes tumor of the breast in pleural effusion.

Diagn Cytopathol 2019 Mar 4. Epub 2019 Mar 4.

Department of Anatomical and Cellular Pathology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong.

A 54-year-old woman presented with a left breast mass, discovered 4 years ago but was static until 2 months before presentation, when it showed a rapid increase in size and became painful. Mammography showed a large lobulated mass with internal cystic components (BI-RADS 4B). A biopsy was performed, followed by modified radical mastectomy. Read More

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http://dx.doi.org/10.1002/dc.24151DOI Listing
March 2019
5 Reads

Coexisting DCIS and phyllodes breast tumors in Young Chinese women: Case series.

Int J Surg Case Rep 2019 8;56:13-16. Epub 2019 Feb 8.

Department of Surgery, New York Presbyterian Queens, United States.

Introduction: Breast cystosarcoma phyllodes tumors are rare and can be benign or malignant. All sub-divisions of phyllodes tumor-benign, borderline and malignant, can harbor carcinomas, although the incidence is extremely rare.

Methods: We present two nonconsecutive cases of coexisting ductal carcinoma in situ (DCIS) and phyllodes breast tumors in young patients. Read More

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http://dx.doi.org/10.1016/j.ijscr.2019.01.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389554PMC
February 2019
1 Read

Expression profile and bioinformatics analysis of COMMD10 in BALB/C mice and human.

Cancer Gene Ther 2019 Feb 21. Epub 2019 Feb 21.

Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China.

COMMD10, a member of COMMD protein, has been proved to target p65 NF-kappaB (nuclear factor-kappaB) subunit and reduce its nuclear translocation, thereby leading to the inactivation of NF-kappaB pathway and suppression of colorectal cancer invasion and metastasis. The aim of this study is to explore its expression pattern and tissue distribution in human normal tissues and other tumor tissues and to investigate the relevant mechanism. We firstly provided the expression profile and histological distribution of COMMD10 in various BALB/c mice tissues and identified the biological distribution of COMMD10 in different kinds of human normal and tumor tissues. Read More

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http://dx.doi.org/10.1038/s41417-019-0087-9DOI Listing
February 2019
1 Read

Long-Term Outcomes After Surgical Treatment of Malignant/Borderline Phyllodes Tumors of the Breast.

Ann Surg Oncol 2019 Feb 19. Epub 2019 Feb 19.

Breast Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Background: Malignant/borderline phyllodes tumors (PTs) are rare, and little is known about their long-term prognosis. This study sought to evaluate recurrence rates and identify factors associated with local and distant failure.

Methods: From 1957 to 2017, we identified 124 patients with 125 PTs (86 malignant and 39 borderline). Read More

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http://dx.doi.org/10.1245/s10434-019-07210-4DOI Listing
February 2019
1 Read

[A Case of a Malignant Phyllodes Tumor That Was Difficult to Distinguish from Stromal Sarcoma].

Gan To Kagaku Ryoho 2018 Dec;45(13):2429-2431

Dept. of Breast and Endocrine Surgery, Osaka City University Graduate School of Medicine.

A 72-year-old woman visited our hospital with the chief complaint of a mass in the right breast. Breast ultrasonography revealed a hypoechoic area with a distinct border in the right breast. A core needle biopsy showed the proliferation of spindle cells in the stroma, and she was diagnosed with stromal sarcoma or malignant phyllodes tumor. Read More

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December 2018
1 Read

[A Case of Metachronal Phyllodes Tumors That Presented Bilaterally in the Breast].

Gan To Kagaku Ryoho 2018 Dec;45(13):1854-1856

Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences.

A 33-year-old woman underwent resection of a right breast mass, which was diagnosed as a fibroadenoma 15 years ago. Ten years later, a right breast mass appeared again, and it was diagnosed as a fibroadenoma based on core needle biopsy. After observation for a while, the mass increased in size, and she underwent resection of the tumor, which was diagnosed as a borderline-malignant phyllodes tumor. Read More

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December 2018
3 Reads

Factors targeting to drive tumorigenesis?

F1000Res 2018 22;7:359. Epub 2018 Mar 22.

Human Genetics, University of Bremen, Bremen, D-28359 , Germany.

Mediator Complex Subunit 12 (MED12) is part of the transcriptional preinitiation machinery. Mutations of its gene predominantly occur in two types of highly frequent benign tumors, uterine leiomyomas and fibroadenomas of the breast, where they apparently act as driver mutations. Nevertheless, their presence is not restricted to benign tumors having been found at considerable frequencies in uterine leiomyosarcomas, malignant phyllodes tumors, and chronic lymphocytic leukemia also. Read More

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https://f1000research.com/articles/7-359/v1
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http://dx.doi.org/10.12688/f1000research.14227.2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325618PMC
March 2018
12 Reads

Local Recurrence of Benign, Borderline, and Malignant Phyllodes Tumors of the Breast: A Systematic Review and Meta-analysis.

Ann Surg Oncol 2019 May 7;26(5):1263-1275. Epub 2019 Jan 7.

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People's Republic of China.

Background: This systematic review and meta-analysis aimed to investigate local recurrence (LR) rates among the three grades (benign, borderline, and malignant) of phyllodes tumors (PTs). The study also assessed various risk factors for LR.

Methods: Electronic articles published between 1 January 1995 and 31 May 2018, were searched and critically appraised. Read More

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http://link.springer.com/10.1245/s10434-018-07134-5
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http://dx.doi.org/10.1245/s10434-018-07134-5DOI Listing
May 2019
9 Reads

Periductal Stromal Tumor of the Breast: Case Report and Literature Review.

Ann Clin Lab Sci 2018 Nov;48(6):770-775

Department of Pathology and Laboratory Medicine, The University of Texas Health Science Center McGovern Medical School, Houston, TX, USA.

Periductal stromal hyperplasia is an exceedingly rare biphasic breast tumor with benign ductal elements and spindle-cell stromal proliferation lacking a phyllodes architecture. It is unclear whether this tumor belongs to the spectrum of phyllodes tumor or is a separate entity. We present a 57-year-old woman with a 3. Read More

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November 2018
1 Read

Phyllodes tumor of the breast with nipple discharge: A case report.

Medicine (Baltimore) 2018 Dec;97(52):e13767

Department of Breast Surgery, West China Hospital, Sichuan University, Chengdu, China.

Rationale: Phyllodes tumors (PTs) of the breast are rare biphasic fibroepithelial neoplasms which usually present with unilateral palpable breast lumps. Here we reported a case of borderline PTs with multifocal intraductal lesions whose primary clinical manifestation was nipple discharge.

Patient Concerns: A rare case of PT with nipple discharge in a 26-year-old young lady accepted a wide local excision on her left breast, and the pathological examination turned out to be a malignant phyllodes tumor. Read More

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http://dx.doi.org/10.1097/MD.0000000000013767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6314703PMC
December 2018

Risk Factors for Recurrence of Malignant Phyllodes Tumors of the Breast.

In Vivo 2019 Jan-Feb;33(1):263-269

Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea.

Background/aim: In this study, the treatment outcome and risk factors for recurrence in patients undergoing surgery with or without adjuvant radiotherapy (RT) for malignant phyllodes tumors of the breast (MPTB) were analyzed.

Patients And Methods: Forty-three patients (61.4%) underwent breast-conserving surgery (BCS) and 27 (38. Read More

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http://iv.iiarjournals.org/lookup/doi/10.21873/invivo.11470
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http://dx.doi.org/10.21873/invivo.11470DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364066PMC
April 2019
12 Reads

Case Report: presentation of pleomorphic liposarcoma arising in a borderline phyllodes tumor.

Int J Surg Case Rep 2018 1;53:490-494. Epub 2018 Nov 1.

University of Biruni, Faculty of Medicine, Department of Pathology, Protokol Yolu No: 45, 10. Yıl Cd., 34010 Zeytinburnu, İstanbul, Turkey. Electronic address:

Introduction: The stromal component of Phyllodes tumors represents the neoplastic portion of the lesion. A variety of associated malignancies can arise from PTs, with its dual population of cells.

Presentation Of Case: We share a very rare case of "borderline"breast phillodes tumour with a 75% liposarcoma component. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S22102612183046
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http://dx.doi.org/10.1016/j.ijscr.2018.10.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6280005PMC
November 2018
15 Reads

Concurrent phyllodes tumor, eccrine carcinoma, and multinodular goiter 20 years after radiotherapy for Hodgkin lymphoma.

Clin Case Rep 2018 Dec 6;6(12):2498-2503. Epub 2018 Nov 6.

Division of Surgical Oncology The James Cancer Hospital at The Ohio State University Columbus Ohio.

This unusual case of concurrent eccrine adenocarcinoma, phyllodes tumor, and multinodular goiter serves to alert the oncologic community to the high prevalence of second cancers after childhood radiotherapy. Increased surveillance and index of suspicion are recommended to successfully diagnose and treat second primary cancers in this vulnerable population. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.1854
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http://dx.doi.org/10.1002/ccr3.1854DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6293260PMC
December 2018
6 Reads

Primary Osteosarcoma of the Breast.

Indian J Surg Oncol 2018 Dec 30;9(4):578-580. Epub 2018 Jul 30.

Department of Surgical Oncology, Bombay Hospital, Bombay hospital Marg, Marine Drive, Mumbai, Maharashtra 400020 India.

Extraskeletal osteosarcomas are extremely rare and account for < 1% of the soft tissue sarcomas. Most common site is in soft tissues of the lower extremities. Primary osteosarcomas of the breast are extremely rare and only a few cases have been reported in literature. Read More

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http://dx.doi.org/10.1007/s13193-018-0787-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6265182PMC
December 2018
3 Reads

Phyllodes tumors of the breast. The treatment results for 340 patients from a single cancer centre.

Breast 2019 Feb 26;43:85-90. Epub 2018 Nov 26.

Department of Surgical Oncology, Centre of Oncology, Maria Sklodowska-Curie Memorial Institute, Cracow Branch, ul. Garncarska 11, 31-115 Cracow, Poland.

Purpose: The primary treatment of choice for patients with phyllodes tumor of the breast (PTB) is surgery. Two major problems regarding the treatment of such patients remain unclear: what is the appropriate surgical margin and what role is played by adjuvant radiotherapy (ART).

Methods: The study provides a retrospective review of all patients with PTB treated between 1952 and 2013 at a single institute. Read More

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http://dx.doi.org/10.1016/j.breast.2018.11.009DOI Listing
February 2019
20 Reads

B7-H3 and B7-H4 expression in phyllodes tumors of the breast detected by RNA in situ hybridization and immunohistochemistry: Association with clinicopathological features and T-cell infiltration.

Tumour Biol 2018 Nov;40(11):1010428318815032

1 Department of Pathology, Chonnam National University Medical School, Gwangju, South Korea.

Phyllodes tumors are rare biphasic breast tumors with the potential for both local recurrence and distant metastasis. The aberrant expression of B7-H3 and B7-H4 B7 molecules could be potential targets for future development of immunotherapeutic approaches. This work was undertaken to evaluate the expression of B7-H3 and B7-H4 in phyllodes tumors and assess the association with the grade and clinical behavior of phyllodes tumors. Read More

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http://dx.doi.org/10.1177/1010428318815032DOI Listing
November 2018
5 Reads

Management of Palpable Pediatric Breast Masses With Ultrasound Characteristics of Fibroadenoma: A More Conservative Approach.

AJR Am J Roentgenol 2019 Feb 26;212(2):450-455. Epub 2018 Nov 26.

1 Department of Radiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390.

Objective: The purpose of this study is to describe our experience with pathologically proven breast masses at a tertiary care pediatric institution, review published management strategies, and propose new management recommendations for the pediatric population.

Materials And Methods: All pediatric breast ultrasound examinations performed at a dedicated pediatric facility over a 4-year period were reviewed. Maximum measurements of solid masses with features of a fibroadenoma were recorded. Read More

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https://www.ajronline.org/doi/10.2214/AJR.17.19482
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http://dx.doi.org/10.2214/AJR.17.19482DOI Listing
February 2019
10 Reads

Recurrent exon 2 mutations in benign breast fibroepithelial lesions in adolescents and young adults.

J Clin Pathol 2019 Mar 22;72(3):258-262. Epub 2018 Nov 22.

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York, USA

Aims: Most benign breast fibroepithelial lesions (FEL) in adults harbour recurrent somatic exon 2 mutations and rare promoter hotspot mutations. We sought to determine the frequency of exon 2 and promoter hotspot mutations in fibroadenomas (FA) and benign phyllodes tumours (BePT) in adolescents and young adults.

Methods: DNA from 21 consecutive FAs and eight consecutive BePTs in adolescents and young adults was subjected to Sanger sequencing of the exon 2 of and the promoter hotspot locus. Read More

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http://dx.doi.org/10.1136/jclinpath-2018-205570DOI Listing
March 2019
19 Reads

Huge borderline phyllodes breast tumor with repeated recurrences and progression toward more malignant phenotype: a case report and literature review.

Onco Targets Ther 2018 2;11:7787-7793. Epub 2018 Nov 2.

Department of Breast Disease and Reconstruction Center, Breast Cancer Key Lab of Dalian, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116027, China,

Background: Phyllodes tumor (PT) is a rare breast fibroepithelial biphasic tumor composed of stromal and epithelial components. The patients suffering from this disease present with a large, round, mobile, fast-growing lump, and the giant PT of more than 10 cm in diameter is so uncommon. Surgery is regarded as the primary treatment, but curative efficiency of adjuvant chemotherapy and radiotherapy is so indefinite. Read More

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http://dx.doi.org/10.2147/OTT.S171714DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223390PMC
November 2018
18 Reads

Malignant phyllodes tumor with metastases to lung, adrenal and brain: A rare case report.

Ann Med Surg (Lond) 2018 Dec 2;36:113-117. Epub 2018 Nov 2.

Department of Dermatology, Tribhuvan University Teaching Hospital, Nepal.

Background: Phyllodes tumors are spectrum of tumors ranging from benign to malignant. Malignant spectrum pose a management challenge for clinicians due to high risks of recurrence and metastasis. Malignant phyllodes tumor with brain, lung and adrenal metastases at the same time is rare. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S20490801183023
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http://dx.doi.org/10.1016/j.amsu.2018.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6230968PMC
December 2018
24 Reads

Expression of biomarkers in the AKT pathway correlates with malignancy and recurrence in phyllodes tumours of the breast.

Histopathology 2019 Mar 15;74(4):567-577. Epub 2019 Jan 15.

Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Hong Kong, Hong Kong.

Aims: Phyllodes tumours (PTs) of the breast are uncommon fibroepithelial neoplasms with the potential to recur and metastasise. Apart from histological grading, the expression of biological markers and its relationship with tumour behaviour have been topics of interest. The phosphatidylinositol 3-kinase (PI3K)-AKT pathway regulates diverse biological functions, and is one of the most frequently deregulated pathways in cancers. Read More

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http://doi.wiley.com/10.1111/his.13782
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http://dx.doi.org/10.1111/his.13782DOI Listing
March 2019
3 Reads

Is Histological Evaluation of Reduction Mammaplasty Specimens Worthwhile?

Aesthet Surg J 2018 Oct 29. Epub 2018 Oct 29.

Department of Plastic, Reconstructive, and Aesthetic Surgery, Dokuz Eylul University, Izmir, Turkey.

Background: Reduction mammaplasty (RM) is one of the most common plastic surgery procedures. Despite its cost, the total number of RM procedures continues to increase every year.

Objectives: The purpose of this study is to review the prevalence of benign and malignant breast lesions among women who live in Aegean region of Turkey, based on our university hospital's records and to compare our results with those in the literature. Read More

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https://academic.oup.com/asj/advance-article/doi/10.1093/asj
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http://dx.doi.org/10.1093/asj/sjy295DOI Listing
October 2018
5 Reads

Cytological Findings in Benign Phyllodes Tumors.

Acta Cytol 2019 26;63(1):23-27. Epub 2018 Oct 26.

Pathology Department, Shiraz University of Medical Sciences, Shiraz,

Objective: Phyllodes tumors are fibroepithelial breast lesions with many cytological and histopathological similarities to fibroadenomas. The aim of this study was to investigate cytological findings in benign phyllodes tumors.

Study Design: Seventy-six histologically proven cases of benign phyllodes tumors were selected from 1982 to 2017. Read More

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http://dx.doi.org/10.1159/000493677DOI Listing
March 2019
3 Reads

Malignant phyllodes tumors of the breast: A single institution experience.

Med J Malaysia 2018 Oct;73(5):297-300

Hospital Queen Elizabeth 2, Breast and Endocrine Department, Kota Kinabalu, Sabah, Malaysia.

Background: Malignant phyllodes tumors of the breast are uncommon fibroepithelial breast tumors with diverse biological behavior. Our study aim is to share our experience in treating patients with malignant phyllodes presenting to our center.

Patients And Methods: A total of 11 cases of malignant phyllodes were retrospectively reviewed between Nov 2014 and Oct 2017. Read More

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October 2018
16 Reads

Invasive lobular carcinoma involving a borderline phyllodes tumor.

Breast J 2018 11 22;24(6):1076-1077. Epub 2018 Oct 22.

Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania.

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http://dx.doi.org/10.1111/tbj.13132DOI Listing
November 2018
3 Reads

Phyllodes tumors of the breast treated in a tertiary health care center: case series and literature review.

J Int Med Res 2018 Oct 14:300060518803530. Epub 2018 Oct 14.

1 Hematology and Oncology Division, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon.

Objective This study was performed to determine the subtypes of phyllodes tumor (PT) in patients at a single tertiary healthcare center in Lebanon and to describe their characteristics along with a review of the literature. Methods This single-institution retrospective cohort study included all cases of PT of the breast treated at the American University of Beirut Medical Center from 1 January 2010 to 31 December 2014. The patients' demographic data, tumor characteristics, treatment data, and pathology reports were analyzed. Read More

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http://dx.doi.org/10.1177/0300060518803530DOI Listing
October 2018
17 Reads

Well-differentiated liposarcoma of the breast arising in a background of malignant phyllodes tumor in a pregnant woman: A rare case report and review of literature.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):577-579

Department of Histopathology, Apollo Cancer Institutes, Chennai, Tamil Nadu, India.

Pure mesenchymal sarcomas and phyllodes tumor with sarcomatous differentiation of the breast are rare tumors. Primary breast sarcomas are a heterogenous group of neoplasms which include malignant fibrous histiocytoma, fibrosarcoma, angiosarcoma, leiomyosarcoma, osteosarcoma, rhabdomyosarcoma, and liposarcoma. Sarcomatous differentiation in phyllodes tumor is seen in the form of angiosarcoma, chondrosarcoma, leiomyosarcoma, osteosarcoma, rhabdomyosarcoma, and liposarcoma. Read More

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http://www.ijpmonline.org/text.asp?2018/61/4/577/242969
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http://dx.doi.org/10.4103/IJPM.IJPM_238_17DOI Listing
February 2019
9 Reads

A Prospective Observational Study of Breast Lumps in Adolescent Girls: Tertiary Care South Indian Teaching Hospital Experience.

Indian J Surg Oncol 2018 Sep 18;9(3):402-406. Epub 2018 May 18.

M.S.Ramaiah Medical College, MSR Nagar, Gokula post, Bangalore, 560054 India.

The aim of the current study was to assess the incidence and varying clinical presentations of benign breast lumps in adolescent age group in a Tertiary care Medical College Hospital. This was a prospective, observational study of 6-year duration (2011 to 2017) conducted in a Medical College, South India. All adolescent age group patients visiting the outpatient department (OPD) with complaints of breast lump were enrolled into the study. Read More

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http://link.springer.com/10.1007/s13193-018-0773-3
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http://dx.doi.org/10.1007/s13193-018-0773-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154352PMC
September 2018
6 Reads

Malignant Spindle Cell Tumor Breast-a Diagnostic Dilemma.

Indian J Surg Oncol 2018 Sep 16;9(3):387-390. Epub 2018 Apr 16.

3Department of Pathology, ESIC Medical College, Faridabad, Haryana India.

Primary malignant spindle cell tumors are rare constituting 1.0% of breast malignancies. Spindle cell lesions occurring in soft tissues can occur in breast with overlapping morphologies. Read More

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http://link.springer.com/10.1007/s13193-018-0750-x
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http://dx.doi.org/10.1007/s13193-018-0750-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154355PMC
September 2018
6 Reads

Fine needle aspiration biopsy cytology of phyllodes tumour and fibroadenoma: A cytomorphological study of 104 cases.

Diagn Cytopathol 2018 Nov 3;46(11):927-935. Epub 2018 Oct 3.

Westmead breast cancer institute, Westmead Hospital, Western Sydney Local Health District, Westmead, New South Wales, Australia.

Background: The cytomorphological features in the distinction between phyllodes tumour (PT) and fibroadenoma (FA) on fine needle aspiration biopsy (FNAB) remains challenging because of the biphasic nature of these lesions and the rarity of PT.

Methods: FNAB smears of histologically confirmed PT (N = 26) and FA (N = 78) cases were retrieved from a retrospective database interrogation from the Department of Cytology/Tissue Pathology, ICPMR Pathology West (Cerner Millennium) in Westmead Hospital. For each case, two smears were selected, de-identified and independently reviewed by four observers comprising two cytologists and two cytopathologists. Read More

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http://doi.wiley.com/10.1002/dc.24021
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http://dx.doi.org/10.1002/dc.24021DOI Listing
November 2018
12 Reads

Distinction between phyllodes tumor and fibroadenoma in breast ultrasound using deep learning image analysis.

Eur J Radiol Open 2018 24;5:165-170. Epub 2018 Sep 24.

Institute for Diagnostic and Interventional Radiology, University Hospital of Zurich, Switzerland.

Purpose: To evaluate the accuracy of a deep learning software (DLS) in the discrimination between phyllodes tumors (PT) and fibroadenomas (FA).

Methods: In this IRB-approved, retrospective, single-center study, we collected all ultrasound images of histologically secured PT (n = 11, 36 images) and a random control group with FA (n = 15, 50 images). The images were analyzed with a DLS designed for industrial grade image analysis, with 33 images withheld from training for validation purposes. Read More

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http://dx.doi.org/10.1016/j.ejro.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6154513PMC
September 2018
4 Reads

Percutaneous removal of benign phyllodes tumor of the breast: An alternative to surgery.

Breast J 2018 11 24;24(6):1035-1037. Epub 2018 Sep 24.

Radiology Department, Lucus Augusti Hospital, Lugo, Spain.

We aimed to evaluate the efficacy of vacuum assisted percutaneous excision in the treatment of benign phyllodes tumors of the breast. From 2007 to 2016, a total of 160 benign fibroepithelial nodules were percutaneously removed in our department. Ultrasonographic follow-up was performed 12 months after the procedure to assess recurrence. Read More

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http://dx.doi.org/10.1111/tbj.13122DOI Listing
November 2018
3 Reads

Stromal Cellular Fragments in Breast Fine Needle Aspirates: Think Outside of the Box.

Acta Cytol 2018 24;62(5-6):450-455. Epub 2018 Sep 24.

Pathology Department, Faculdade de Medicina da Universidade do Porto, Porto,

Background: The presence of highly cellular stromal fragments in breast fine needle aspirates (FNA) suggests some classical differential diagnoses such as cellular fibroadenoma, phyllodes tumour (PT), metaplastic carcinomas, and some mesenchymal/myoepithelial proliferations. The other components of the smears can help in the differential diagnosis, but the presence of a low-grade epithelial proliferation does not always represent a fibro-epithelial lesion as we demonstrate in these two cases.

Cases: We discuss two cases of breast FNA, previously presented in a slide seminar at the 29th European Congress of Pathology in Amsterdam, where the common cytological finding was the presence of stromal cellular fragments together with an epithelial component. Read More

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https://www.karger.com/Article/FullText/492566
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http://dx.doi.org/10.1159/000492566DOI Listing
January 2019
17 Reads

Malignant phyllodes tumor metastatic to bilateral ovaries: A Krukenberg-like presentation.

J Cancer Res Ther 2018 Jul-Sep;14(5):1138-1141

Department of Histopathology and Cytopathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Phyllodes tumor (PT) is an extremely rare tumor of the breast of mixed mesenchymal and epithelial origin. It may pursue a benign or malignant evolution with distant metastases in the latter case in 3-12% of patients. The most common sites of metastases are the lungs and bones. Read More

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http://dx.doi.org/10.4103/0973-1482.184515DOI Listing
October 2018
6 Reads

Effect of postoperative time for adjuvant radiotherapy in malignant phyllodes tumor: An institutional experience.

J Cancer Res Ther 2018 Jul-Sep;14(5):1054-1058

Department of Radiation Oncology, Gandhi Medical College, Bhopal, Madhya Pradesh, India.

Introduction: Cystosarcoma phyllodes of the breast, an uncommon sarcoma found primarily in women of the age group of 35-55 years, constitutes <1% of all breast neoplasms. These tumors are resistant to chemotherapy and hormonal therapies and often recur aggressively after initial surgery. Limited research is available about the role and effectiveness of adjuvant radiotherapy in reducing recurrences. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_172_16DOI Listing
October 2018
11 Reads

Time to revise classification of phyllodes tumors of breast? Results of a French multicentric study.

Eur J Surg Oncol 2018 11 18;44(11):1743-1749. Epub 2018 Aug 18.

Service de Gynécologie, CHU de Rennes, Hôpital sud, 16 Bd de Bulgarie, 35000, Rennes, France; Service de Sénologie, CRLC Eugène Marquis, Avenue de Bataille Flandres Dunkerque, 35000, Rennes, France; INSERM 1242, Chemistry, Oncogenesis, Stress and Signaling, Rennes, France. Electronic address:

Objective: To assess prognostic factors of recurrence of phyllodes tumors (PT) of the breast.

Methods: We performed a retrospective, multicentric cohort study, including all patients who underwent breast surgery for grade 1 (benign), 2 (borderline) or 3 (malignant) PT between 2000 and 2016 in five tertiary University hospitals, diagnosed according to World Health Organisation classification.

Results: 230 patients were included: 144 (63%), 60 (26%) and 26 (11%) with grade 1, 2 and 3 PT, respectively. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07487983183127
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http://dx.doi.org/10.1016/j.ejso.2018.08.007DOI Listing
November 2018
12 Reads

Recurrence Rates and Characteristics of Phyllodes Tumors Diagnosed by Ultrasound-guided Vacuum-assisted Breast Biopsy (VABB).

Anticancer Res 2018 Sep;38(9):5481-5487

Department of Diagnostic Pathology, Gangnam CHA Medical Center, College of Medicine, CHA University, Seoul, Republic of Korea.

Background/aim: Recently, the development of ultrasonography (US)-guided vacuum-assisted breast biopsy (VABB) has enabled the excision of benign breast tumors with normal surrounding breast tissues; thus, complete excision is possible without residual tumor tissue. We sought to identify the clinicopathological characteristics and recurrence rates of benign phyllodes tumors diagnosed by US-guided VABB.

Patients And Methods: Data from 11,221 US-guided VABBs performed at the Gangnam Cha Medical Center over 12 years were analyzed. Read More

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http://dx.doi.org/10.21873/anticanres.12881DOI Listing
September 2018
25 Reads

Breast Lesions in Children and Adolescents: Diagnosis and Management.

Korean J Radiol 2018 Sep-Oct;19(5):978-991. Epub 2018 Aug 6.

Department of Radiology, Soonchunhyang University Seoul Hospital, Seoul 04401, Korea.

Pediatric breast disease is uncommon, and primary breast carcinoma in children is extremely rare. Therefore, the approach used to address breast lesions in pediatric patients differs from that in adults in many ways. Knowledge of the normal imaging features at various stages of development and the characteristics of breast disease in the pediatric population can help the radiologist to make confident diagnoses and manage patients appropriately. Read More

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http://dx.doi.org/10.3348/kjr.2018.19.5.978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082765PMC
April 2019
16 Reads

Educational Case: Fibroadenoma of the Breast.

Authors:
H James Williams

Acad Pathol 2018 Jan-Dec;5:2374289518790926. Epub 2018 Aug 24.

West Virginia University Health Sciences Center, Morgantown, WV, USA.

The following fictional case is intended as a learning tool within the Pathology Competencies for Medical Education (PCME), a set of national standards for teaching pathology. These are divided into three basic competencies: Disease Mechanisms and Processes, Organ System Pathology, and Diagnostic Medicine and Therapeutic Pathology. For additional information, and a full list of learning objectives for all three competencies, see http://journals. Read More

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http://dx.doi.org/10.1177/2374289518790926DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6109836PMC
August 2018
1 Read

Malignant Phyllodes tumor in a young female: A Case Report.

Gulf J Oncolog 2018 May;1(27):64-69

Pathology Department, Hindurao Hospital and NDMC Medical college, New Delhi, India.

Phyllodes tumor is a rare fibroepithelial neoplasm of the breast and constitutes 0.3-0.5% of all breast tumors. Read More

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May 2018
24 Reads

Laminin 332 expression and prognosis in breast cancer.

Hum Pathol 2018 Dec 17;82:289-296. Epub 2018 Aug 17.

Department of Epidemiology, University of California, Irvine, CA 92697-7550, USA.

The purpose of this study was to determine the distribution of and potential significance of laminin 332 (LM332) in breast cancer. Specimens from a population-based cohort (N = 297) from 1994 to 1995 were stained for estrogen receptor (ER), progesterone receptor (PgR), HER2 and the LM332 β3 chain. Seventy-five tumors were LM332-positive and 222 were negative. Read More

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http://dx.doi.org/10.1016/j.humpath.2018.08.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289632PMC
December 2018
15 Reads