13,479 results match your criteria Cystitis Nonbacterial


Efficacy and Safety of Non-Invasive Intravesical Instillation of Onabotulinum Toxin-A for Overactive Bladder and Interstitial Cystitis/Bladder Pain Syndrome: Systematic Review and Meta-analysis.

Urology 2018 Dec 12. Epub 2018 Dec 12.

Department of Urology, Soonchunhyang University Seoul Hospital, Soonchunhyang University Medical College, Seoul, South Korea. Electronic address:

Objective: To investigate the efficacy and safety of non-invasive intravesical instillation of OBTX-A through systematic review and meta-analysis. Recently, several studies of non-invasive intravesical instillation of Onabotulinum Toxin-A (OBTX-A) have been published. However, its efficacy is not well validated yet compared to well-known efficacy of minimally invasive intravesical injection of OBTX-A. Read More

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December 2018
1 Read

Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP receptor antagonist.

Naunyn Schmiedebergs Arch Pharmacol 2018 Dec 14. Epub 2018 Dec 14.

Department of Pharmacology and Toxicology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.

Various studies have confirmed that prostaglandins (PG) alter the bladder motor activity and micturition reflex in both human and animals. However, no sufficient data is reported about the effect of cyclooxygenase (COX) inhibitors neither in normal bladder physiology nor in pathological conditions. This study aims to compare the potential effects of some COX inhibitors with varying COX-1/COX-2 selectivities (indomethacin, ketoprofen, and diclofenac) with that of the selective COX-2 inhibitor (DFU) on bladder function. Read More

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December 2018

[A Case of Refractory Hemorrhagic Cystitis in which Bleeding Control was Finally Achieved by Cystectomy].

Hinyokika Kiyo 2018 Oct;64(10):415-418

Hakodate Goryokaku Hospital.

A 60-year-old man presented at our hospital with gross hematuria. He had been treated for nephrotic syndrome with cyclophosphamide and steroids since he was in his 20s. We detected diffuse hemorrhagic cystitis on cystoscopy and diagnosed him with cyclophosphamide-induced hemorrhagic cystitis. Read More

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October 2018

Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner.

PLoS Pathog 2018 Dec 13;14(12):e1007457. Epub 2018 Dec 13.

Department of Molecular Microbiology and Center for Women's Infectious Disease Research, Washington University School of Medicine, St. Louis, Missouri, United States of America.

Urinary tract infections (UTI) are extremely common and can be highly recurrent, with 1-2% of women suffering from six or more recurrent episodes per year. The high incidence of recurrent UTI, including recurrent infections caused by the same bacterial strain that caused the first infection, suggests that at least some women do not mount a protective adaptive immune response to UTI. Here we observed in a mouse model of cystitis (bladder infection) that infection with two different clinical uropathogenic Escherichia coli (UPEC) isolates, UTI89 or CFT073, resulted in different kinetics of bacterial clearance and different susceptibility to same-strain recurrent infection. Read More

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December 2018

A Novel Camptothecin Derivative 3j Inhibits Nsclc Proliferation Via Induction of Cell Cycle Arrest By Topo I-Mediated DNA Damage.

Anticancer Agents Med Chem 2018 Dec 6. Epub 2018 Dec 6.

Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu. China.

Objective: The aim of this study is to investigate the inhibitory effect of camptothecin derivative 3j on non-small cell lung cancer (NSCLCs) cells and the potential anti-tumor mechanisms.

Background: Camptothecin compounds are considered as the third largest natural drugs which are widely investigated in the world and they suffered restriction because of serious toxicity, such as hemorrhagic cystitis and bone marrow suppression.

Methods: Using cell proliferation assay and S180 tumor mice model, a series of 20(S)-O-substituted benzoyl 7-ethylcamptothecin compounds were screened and evaluated the antitumor activities in vitro and in vivo. Read More

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December 2018

[Investigation of the diagnostic value of anti-dense fine speckled 70/lens epithelium derived growth factor p75 autoantibody for autoimmune diseases].

Mikrobiyol Bul 2018 Oct;52(4):413-424

Ankara Training and Research Hospital, Clinic of Medical Microbiology, Ankara, Turkey.

Antinuclear antibodies (ANA) are the autoantibodies that are produced against nuclear antigens in the cell nucleus and/or cytoplasm, and are one of the important diagnostic criteria in systemic autoimmune rheumatic diseases (SARD). Until today, several methods have been developed for detecting ANA's. However, indirect immunofluorescence (IIF) technique, that is also known as one of the oldest methods, is still the most commonly used one. Read More

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October 2018

[Diagnostic value of the BRAF variant V595E in urine samples, smears and biopsies from canine transitional cell carcinoma].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2018 Oct 12;46(5):289-295. Epub 2018 Dec 12.

Objective: Transitional cell carcinoma (TCC) is the most common malignant tumour of the canine urinary tract. Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine. The objective of this study was to establish these methods in cytological smears and to investigate the prevalence of BRAF mutation V595E in canine TCC in our cohort of patients. Read More

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October 2018
2 Reads

Antimicrobial Susceptibility Trends Observed in Urinary Pathogens Obtained From New York State.

Open Forum Infect Dis 2018 Nov 16;5(11):ofy297. Epub 2018 Nov 16.

Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York.

International guidelines recommend using local susceptibility data to direct empiric therapy for acute uncomplicated cystitis. We evaluated outpatient urinary isolate susceptibility trends in New York State. Nitrofurantoin had the lowest resistance prevalence whereas trimethoprim-sulfamethoxazole and fluoroquinolones had higher prevalences. Read More

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November 2018

Diabetic bladder dysfunction is associated with bladder inflammation triggered through hyperglycemia, not polyuria.

Res Rep Urol 2018 16;10:219-225. Epub 2018 Nov 16.

Department of Surgery, Division of Urology, Duke University Medical Center, Durham, NC, USA,

Purpose: Diabetes is a grave and progressive condition characterized by debilitating complications. Diabetic bladder dysfunction (DBD) is a very common complication with no specific treatments currently available. Unlike other tissues affected by this disease, the bladder is subjected to two independent insults; 1) polyuria, created by the osmotic effects of glucose in the urine, and 2) hyperglycemia itself. Read More

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November 2018

Donor lymphocyte infusion for BK virus hemorrhagic cystitis and nephropathy: a case report.

Bone Marrow Transplant 2018 Dec 5. Epub 2018 Dec 5.

Hematology Department. Hospital Universitari Vall d'Hebron, VHIO, Departament de Medicina. Universitat Autònoma de Barcelona, Barcelona, Spain.

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December 2018
4 Reads

[Research Progress on BK Virus Infection after Hematopoietic Stem Cell Transplantation--Review].

Zhongguo Shi Yan Xue Ye Xue Za Zhi 2018 Dec;26(6):1868-1871

Department of Hematology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing 400010, China.

BK virus infection is one of the common complications after hematopoietic stem cell transplantation(HSCT), which is also one of the reasons of the hemorrhagic cystitis.In recent years, although there are more studies of the risk factors related with human BK virus infection after hematopoietic stem cell transplantation, the risk factors related with BKV-associated hemorrhagio cystitis(BKV-HC) remain to be elucidated. Diagnosis of BK virus infection is mainly based on quantitative PCR of blood or urine. An effective strategy for treatment of these patients is the adoptive transfer of T lymphocytes specific to virus-associated antigens. Read More

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December 2018

Clinical, histopathologic, cystoscopic, and fluorescence in situ hybridization analysis of proliferative urethritis in 22 dogs.

J Vet Intern Med 2018 Dec 5. Epub 2018 Dec 5.

Department of Medicine and Epidemiology, Veterinary Medical Teaching Hospital, University of California-Davis School of Veterinary Medicine, California.

Background: Proliferative urethritis (PU) is a lower urinary tract disease of dogs characterized by frond-like lesions in the urethra. The etiology of PU is unknown, although an association with bacterial cystitis is reported.

Objectives: Deep-seated bacterial cystitis is associated with PU, particularly in dogs with neutrophilic or granulomatous inflammation. Read More

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December 2018
1 Read

Keratinizing squamous metaplasia of the bladder: Our experience and current approaches.

Urologia 2018 Dec 3:391560318810197. Epub 2018 Dec 3.

2 Pathology Unit, ASST-Rhodense, Milan, Italy.

Introduction:: Bladder mucosa is anatomically covered by urothelial epithelium. The replacement of the urothelium with stratified squamous cells is defined as squamous metaplasia which can be keratinizing or non-keratinizing. Clinically, it is also known as leukoplakia or keratinizing cystitis of the bladder. Read More

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December 2018
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The effect of herpes simplex virus vector-mediated gene therapy of protein phosphatase 1α on bladder overactivity and nociception.

Neurourol Urodyn 2018 Nov 29. Epub 2018 Nov 29.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Aims: We studied the effect of herpes simplex virus (HSV) vectors-based gene transfer of protein phosphatase 1α (PP1α) on bladder hypersensitivity in rats.

Methods: Using adult female Sprague-Dawley rats, non-replicating HSV vectors carrying PP1α or green fluorescent protein (GFP) were injected into the bladder wall. At one week after vector inoculation, cystometry and Western blot assay were performed, whereas the other experiments were performed at 2 weeks after vector inoculation. Read More

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November 2018
1 Read

Sexual and bladder dysfunction in male ketamine abusers: A large-scale questionnaire study.

PLoS One 2018 28;13(11):e0207927. Epub 2018 Nov 28.

Department of Urology, Taipei Tzu Chi Hospital, New Taipei, Taiwan.

Purpose: To evaluate the prevalence of lower urinary tract symptoms (LUTS) and erectile dysfunction (ED) in the illicit male ketamine abusers (KA).

Materials And Methods: The male street KAs caught by policemen and patients visiting urologic clinics were invited to answer a structured questionnaire including demographic data, illicit drug use related details (duration, frequency, dosage and abstinence status), international prostate symptoms score (IPSS), interstitial cystitis symptoms and problem index (ICSI and ICPI) and International index of erectile function (IIEF-5). Erectile dysfunction was defined as IIEF-5 ≦21. Read More

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November 2018

Emphysematous Cystitis.

J Belg Soc Radiol 2018 Oct 12;102(1):66. Epub 2018 Oct 12.

Sint-Andriesziekenhuis, Tielt, BE.

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October 2018

Extracorporeal shockwave against inflammation mediated by GPR120 receptor in cyclophosphamide-induced rat cystitis model.

Mol Med 2018 11 27;24(1):60. Epub 2018 Nov 27.

Center for Shockwave Medicine and Tissue Engineering, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 83301, Taiwan.

Background: We tested the hypothesis that extracorporeal shockwave treatment (ESWT) can abolish inflammation and restore urothelial barrier integrity in acute interstitial cystitis by upregulating the fatty acid receptor GPR120.

Methods: A total of 30 female Sprague-Dawley rats were categorized into five groups: (1) sham-operated rats (SC); (2) rats treated with ESWT (SC + ESWT); (3) rats with bladder irritation using 150 mg/kg cyclophosphamide through intraperitoneal injection; (4) cyclophosphamide rats treated with ESWT (cyclophosphamide+ESWT); (5) cyclophosphamide rats treated with GPR120 agonist (cyclophosphamide+GW9508).

Results: On Day 3, urine and bladder specimens were collected for biochemical, histopathological, immunological, and immunoblotting analysis. Read More

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November 2018
1 Read
4.508 Impact Factor

Urinary capillariosis in a free-ranging Marsican brown bear ().

Int J Parasitol Parasites Wildl 2018 Dec 7;7(3):429-431. Epub 2018 Nov 7.

Dipartimento di Scienze Veterinarie, Viale delle Piagge 2, 56124, Pisa, Italy.

Extraintestinal nematodes have been seldom investigated in the brown bear (). In this study, a case of urinary capillariosis and bladder associated lesions is reported in a deceased free-ranging Marsican brown bear () from Central Italy. Gross lesions in the urinary bladder consisted of scattered foci of mucosal hyperemia, while at histological examination mild cystitis was observed. Read More

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December 2018

[Burning sensation during urination].

MMW Fortschr Med 2018 Nov;160(20):52-55

Urologische Klinik und Poliklinik, Klinikum der Universität München, Ludwig-Maximilians-Universität München, Marchioninistraße 15, D-81377, München, Deutschland.

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November 2018
1 Read

Safety and efficacy of Intravesical hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome.

Turk J Urol 2018 Nov 21:1-6. Epub 2018 Nov 21.

Department of Urology, Benha University, Benha, Egypt.

Objective: To evaluate the safety and efficacy of intravesical instillation of hyaluronic acid/chondroitin sulfate in the treatment of refractory painful bladder syndrome.

Material And Methods: Forty patients were subjected to intravesical instillations of hyaluronic acid/chondroitin sulfate weekly for 4 weeks and at 6., 8. Read More

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November 2018

Chronic Urinary Retention due to Fowler's Syndrome.

European J Pediatr Surg Rep 2018 Jan 18;6(1):e77-e80. Epub 2018 Oct 18.

Department of Paediatric Surgery and Urology, Motol University Hospital, Charles University in Prague, Prague, Czech Republic.

Fowler's syndrome (FS) is a rare cause of chronic urinary retention in teenage girls and young women. We present a case of a 14-year-old girl who presented at our hospital 2 weeks after uncomplicated laparoscopic appendectomy. The girl complained of reduced urinary frequency and prolonged micturition time. Read More

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January 2018
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An Overview of the Pathology and Emerging Treatment Approaches for Interstitial Cystitis/Bladder Pain Syndrome.

Cureus 2018 Sep 17;10(9):e3321. Epub 2018 Sep 17.

Hematology/Oncology, University of Arizona Cancer Center, Tucson, USA.

Our article will discuss bladder pain syndrome (BPS), which is the presence of chronic suprapubic pain to bladder filling accompanied by other urinary symptoms, such as frequency, urgency, discomfort with filling, and relief with emptying of the bladder in the absence of infections or other pathology. It is mostly seen in females and occurs in 0.06%-30% of the population. Read More

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September 2018
2 Reads

Recent advances in imaging and understanding interstitial cystitis.

F1000Res 2018 9;7. Epub 2018 Nov 9.

Urology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, 15213, USA.

Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition associated with intense pelvic pain and bladder storage symptoms. Since diagnosis is difficult, prevalence estimates vary with the methodology used. There is also a lack of proven imaging tools and biomarkers to assist in differentiation of IC/BPS from other urinary disorders (overactive bladder, vulvodynia, endometriosis, and prostatitis). Read More

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November 2018
1 Read

Infectious and Inflammatory Diseases of the Urinary Tract: Role of MR Imaging.

Magn Reson Imaging Clin N Am 2019 Feb 29;27(1):59-75. Epub 2018 Oct 29.

Department of Radiology, Hospital Garcia de Orta, Av. Torrado da Silva, 2805-267 Almada, Portugal; Department of Radiology, Hospital da Luz, Estrada Nacional 10, km 37, Setúbal 2900-722, Portugal. Electronic address:

Urinary tract infection (UTI) is among the most common of bacterial infections. Imaging studies are only required in cases of complicated UTIs. Ultrasound remains the first-line imaging method; however, CT is the gold standard for evaluation of UTIs. Read More

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February 2019
5 Reads

Omphalitis, urachocystitis and septicemia by Streptococcus dysgalactiae in a southern right whale calf Eubalaena australis, Brazil.

Dis Aquat Organ 2018 Nov;131(3):227-232

Setor de Patologia Veterinária, Faculdade de Veterinária (FAVET), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul (RS) 91540-000, Brazil.

Southern right whales Eubalaena australis (SRW) use the southern coast of Brazil as a wintering and calving ground. Other than anthropogenic threats, there is limited knowledge on health and disease aspects for this species. We report the gross and microscopic findings and microbiological identification of streptococcal septicemia in a SRW calf. Read More

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November 2018
1 Read

Cystoscopic evaluation and clinical phenotyping in ınterstitial cystitis / Bladder pain syndrome.

J Turk Ger Gynecol Assoc 2018 Nov 20. Epub 2018 Nov 20.

Department of Urology, Marmara University School of Medicine, İstanbul, Turkey.

Herein, we aimed to review, report and discuss the role of cystoscopy and clinical phenotyping in interstitial cystitis/bladder pain syndrome (IC/BPS). For this purpose; a comprehensive nonsystematic review of the relevant literature was conducted. We reviewed articles published in English and indexed in the PubMed, Embase, and Google Scholar databases. Read More

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November 2018
3 Reads

Analysis of key genes and micro-RNA-mRNA regulatory networks in women with ulcerative interstitial cystitis/pain bladder syndrome.

Int Urogynecol J 2018 Nov 19. Epub 2018 Nov 19.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China.

Introduction And Hypothesis: This aim of this study was to better understand ulcerative interstitial cystitis/painful bladder syndrome (IC/PBS) at the molecular level and provide new clues related to diagnosis and treatment.

Methods: The microarray data set GSE11783, including the mRNA and miRNA profiles of bladder tissue obtained at cystoscopic biopsy from patients with ulcerative IC/PBS (presence of at least one Hunner's ulcer) and normal controls, was downloaded from the GEO (Gene Expression Omnibus) database (National Center for Biotechnology Information). These were evaluated using Greenspring GX and Ingenuity Pathway Analysis (IPA) software. Read More

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November 2018
3 Reads

SYMPTOM DURATION IN PATIENTS WITH UROLOGIC CHRONIC PELVIC PAIN SYNDROME (UCPPS) IS NOT ASSOCIATED WITH PAIN SEVERITY, NON-UROLOGIC SYNDROMES AND MENTAL HEALTH SYMPTOMS: A MULTIDISCIPLINARY APPROACH TO THE STUDY OF CHRONIC PELVIC PAIN (MAPP) NETWORK STUDY.

Urology 2018 Nov 16. Epub 2018 Nov 16.

Departments of Medicine and Psychiatry, The Geffen School of Medicine at UCLA, Los Angeles, CA.

Objective: To evaluate if patients with urologic chronic pelvic pain syndromes (UCPPS) with longer duration of symptoms experience more severe pain and urologic symptoms, higher rates of chronic overlapping pain conditions (COPC) and psychosocial comorbidities than those with a more recent onset of the condition. We evaluated cross-sectional associations between UCPPS symptom duration and 1) symptom severity, 2) presence of COPC, and 3) mental health comorbidities.

Methods: We analyzed baseline data from the Multidisciplinary Approach to the Study of Chronic Pelvic Pain (MAPP). Read More

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November 2018
4 Reads

Hemorrhagic Cystitis: Treatment With Hyperbaric Oxygen Therapy in Patients With Acute Lymphoblastic Leukemia.

Clin J Oncol Nurs 2018 Dec;22(6):E146-E151

Scripps MD Anderson Cancer Center, Sanford Burnham Presbys Medical Discovery Institute, and Scripps Research Translational Institute.

Background: Hyperbaric oxygen therapy is a rare treatment modality for hemorrhagic cystitis (HC) following BK virus reactivation in the immunosuppressed population. Clinicians need to be aware of the etiology, preventive measures, complications, and various management techniques in HC while treating patients undergoing bone marrow transplantation.

Objectives: This study details the pathologic progression of HC in a patient with acute lymphoblastic leukemia harboring BK virus after cytotoxic induction chemotherapy and haploidentical marrow transplantation. Read More

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December 2018
6 Reads

[Emphysematous cystitis in a patient with type-1diabetes mellitus - diagnostic difficulties].

Wiad Lek 2018 ;71(7):1424-1428

Katedra I Zakład Medycyny Rodzinnej, Warszawski Uniwersytet Medyczny, Warszawa, Polska.

A case report of 28 year old female with medical history of bed controlled type 1 diabetes mellitus complicated by autonomic neuropathy in the form of gastroparesis, suffered by emphysematous cystitis caused by Escherichia coli was described. Emphysematous cystitis is a rare urinary tract infection connected with the presence of gas in the bladder lumen or/and within the bladder wall, which occurs mainly in women, in older age, suffering from type 2 diabetes, complicated by microangiopathy, neuropathy, with urinary tract obstruction and weakness of immunity system. Diagnostic difficulties and the delay in correct diagnosis in described case were caused by the dominated complaint of the upper gastrointestinal tract and difficulties in interpretation of imaging methods, such as abdominal X-ray and ultrasound scan. Read More

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January 2018
5 Reads

Distribution of virulence genes and their association with antimicrobial resistance among uropathogenic Escherichia coli isolates from Iranian patients.

BMC Infect Dis 2018 Nov 15;18(1):572. Epub 2018 Nov 15.

Department of Urology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Urinary tract infections (UTIs) are one of the most frequent diseases encountered by humans worldwide. The presence of multidrug-resistant (MDR) uropathogenic Escherichia coli (UPEC) harboring several virulence factors, is a major risk factor for inpatients. We sought to investigate the rate of antibiotic resistance and virulence-associated genes among the UPECs isolated from an Iranian symptomatic population. Read More

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November 2018
4 Reads

Diffusion-Weighted Magnetic Resonance Imaging: A New Tool for the Diagnosis of Bladder Pain Syndrome/Interstitial Cystitis.

Urol Int 2018 Nov 14:1-4. Epub 2018 Nov 14.

Department of Neurourology, Tenon Hospital, APHP, Paris, France.

Objectives: To determine whether diffusion-weighted magnetic resonance imaging (DWMRI), a noninvasive procedure, can contribute to the diagnosis of bladder pain syndrome/interstitial cystitis (BPS/IC).

Methods: The pelvic DWMRI of patients with chronic pelvic pain syndrome was selected between January 2012 and June 2017. A radiologist analyzed the bladder wall signal; he was blinded to the patients' clinical data. Read More

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November 2018
2 Reads

Randomized, double-blind, placebo-controlled phase II trial of nanocurcumin in prostate cancer patients undergoing radiotherapy.

Phytother Res 2018 Nov 14. Epub 2018 Nov 14.

Urology and Nephrology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Clinical potential of curcumin in radiotherapy (RT) setting is outstanding and of high interest. The main purpose of this randomized controlled trial (RCT) was to assess the beneficial role of nanocurcumin to prevent and/or mitigate radiation-induced proctitis in prostate cancer patients undergoing RT. In this parallel-group study, 64 eligible patients with prostate cancer were randomized to receive either oral nanocurcumin (120 mg/day) or placebo 3 days before and during the RT course. Read More

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November 2018
5 Reads

Simultaneous occurrence of hypermucoviscous emphysematous prostatic abscess, emphysematous cystitis, and renal abscess.

IDCases 2018 3;14:e00464. Epub 2018 Nov 3.

Division of General Medicine, Department of Internal Medicine, Nihon University School of Medicine, Tokyo, 173-8610, Japan.

Emphysematous prostatic abscess is a rare clinical entity of uncomplicated urinary tract infections with high mortality rate. Here we report a case of hypermucoviscous causing emphysematous prostatic abscess, emphysematous cystitis, and renal abscess simultaneously in a 75-year-old Japanese male with diabetes mellitus and advanced gastric cancer. The patient was successfully treated with prolonged intravenous antimicrobial agents. Read More

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November 2018
3 Reads

The efficacy and safety of tazobactam/ceftolozane in Japanese patients with uncomplicated pyelonephritis and complicated urinary tract infection.

J Infect Chemother 2018 Nov 9. Epub 2018 Nov 9.

Japan Development, MSD K.K., Tokyo, Japan. Electronic address:

We report efficacy and safety results for a combination of a novel cephalosporin class antibiotic and a β-Lactamase inhibitor, tazobactam/ceftolozane (1:2) at a dose of 1.5 g intravenously every 8 h in Japanese patients with uncomplicated pyelonephritis and complicated urinary tract infection. This study design was a nonrandomized, multicenter, open-label trial, and the treatment period was 7 days. Read More

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November 2018
6 Reads

Overactive bladder symptom bother and health-related quality of life in patients with systemic lupus erythematosus and primary Sjögren syndrome.

Lupus 2018 Nov 12:961203318811605. Epub 2018 Nov 12.

1 Urology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Centro Académico de Medicina de Lisboa, Lisbon, Portugal.

Objective: The objective of this paper is to assess overactive bladder (OAB) symptom bother (SB) and health-related quality of life (HRQL) among patients with systemic lupus erythematosus (SLE) and primary Sjögren syndrome (pSS).

Methods: We recruited adult SLE and pSS patients and two groups of age- and sex-matched controls. We applied the OAB questionnaire-short form (OABq-SF) to all participants to assess SB and HRQL and collected clinical information relevant for OAB. Read More

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November 2018
1 Read

Reliability of Symptom-Based Diagnosis of Uncomplicated Cystitis.

Urol Int 2018 Nov 12:1-13. Epub 2018 Nov 12.

Clinic of Urology, Paediatric Urology and Andrology, Justus-Liebig-University, Giessen, Germany.

Background And Objectives: Acute uncomplicated cystitis (AC) is common among women. Acute onset of specific typical symptoms may serve as reliable criteria for developing a cost-effective strategy to make an accurate diagnosis of AC. We aimed to evaluate the diagnostic values of most common symptoms and signs of AC depending on their presence and severity. Read More

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November 2018
1 Read

Re: A Randomized, Double-blind, Placebo-controlled Trial of Certolizumab Pegol in Women with Refractory Interstitial Cystitis/Bladder Pain Syndrome.

Eur Urol 2018 Nov 8. Epub 2018 Nov 8.

Department of General, Oncological and Functional Urology, Medical University of Warsaw, Warsaw, Poland.

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November 2018

ALternatives To prophylactic Antibiotics for the treatment of Recurrent urinary tract infection in women (ALTAR): study protocol for a multicentre, pragmatic, patient-randomised, non-inferiority trial.

Trials 2018 Nov 9;19(1):616. Epub 2018 Nov 9.

Department of Urology, Freeman Hospital, Freeman Road, Newcastle upon Tyne, NE7 7DN, UK.

Background: At least half of all adult women will experience infective cystitis (urinary tract infection: UTI) at least once in their life and many suffer from repeated episodes. Recurrent urinary tract infection (rUTI) in adult women is usually treated with long-term, low-dose antibiotics and current national and international guidelines recommend this as the 'gold standard' preventative treatment. Although they are reasonably effective, long-term antibiotics can result in bacteria becoming resistant not only to the prescribed antibiotic but to other antimicrobial agents. Read More

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November 2018
8 Reads

Hyperbaric oxygen significantly improves frequent urination, hyperalgesia, and tissue damage in a mouse long-lasting cystitis model induced by an intravesical instillation of hydrogen peroxide.

Neurourol Urodyn 2018 Nov 9. Epub 2018 Nov 9.

Department of Urology, Osaka City University Graduate School of Medicine, Osaka, Japan.

Aim: To investigate whether hyperbaric oxygen (HBO) is effective for the pathophysiological findings in an IC/PBS-like mouse model induced by intravesical hydrogen peroxide (H O ).

Methods: Six-week-old ICR female mice (N = 16) were divided into four experimental groups: (1) sham control with intravesical vehicle instillation twice, and without subsequent treatment (N = 4); (2) H O instillation twice, followed by HBO (100% O , 2 ATA, 30 min per session) (N = 4); (3) H O instillation twice, followed by dummy hyperbaric treatment (air, 2ATA, 30 min per session) (N = 4); and (4) H O instillation twice, followed by no treatment (N = 4). Body weight, voiding frequency, tidal voiding volume, and individual bladder pain threshold using the von-Frey test were measured. Read More

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November 2018
7 Reads

Spinal cord stimulation ameliorates detrusor over-activity and visceromotor pain responses in rats with cystitis.

Neurourol Urodyn 2018 Nov 9. Epub 2018 Nov 9.

Department of Urology, University of Southern California, Los Angeles, California.

Aim: Interstitial cystitis/painful bladder syndrome/(IC/PBS) results in recurring pain in the bladder and surrounding pelvic region caused by abnormal excitability of micturition reflexes. Spinal cord stimulation (SCS) is currently clinically used for the attenuation of neuropathic and visceral pain. The present study examined whether SCS at upper lumbar segments modulates detrusor overactivity and visceral hyperalgesia associated with cystitis in a rat model of cyclophosphamide (CYP)-induced cystitis. Read More

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November 2018
1 Read

Emphysematous pyelonephritis and cystitis in a patient with uremia and anuria: A case report and literature review.

Medicine (Baltimore) 2018 Nov;97(45):e11272

Department of Nephrology, Qilu Hospital of Shandong University (Qingdao).

Introduction: Emphysematous pyelonephritis (EPN) or cystitis (EC) is a severe infection of the urinary tract with high mortality. EPN is uncommon among the patients of end stage of renal failure (ESRD) CASE PRESENTATION:: A 38-year-old male with uremia and anuria who was on hemodialysis was found to have gas formation in the bilateral pelvis, ureters, and urinary bladder by CT scan. The diagnosis was emphysematous pyelonephritis and cystitis. Read More

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November 2018
22 Reads

A rare x-ray image of emphysematous cystitis.

Urol Case Rep 2019 Jan 25;22:40-41. Epub 2018 Oct 25.

Princess Alexandra Hospital, 199 Ipswich Road, Woolloongabba, Queensland, 4102, Australia.

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January 2019
1 Read

A systematic review of single-dose aminoglycoside therapy for urinary tract infection: Is it time to resurrect an old strategy?

Antimicrob Agents Chemother 2018 Nov 5. Epub 2018 Nov 5.

Department of Pharmacy Services, St. Joseph's Hospital and Medical Center, Phoenix, AZ.

: Increasing bacterial resistance and poor patient adherence rates limit the effectiveness of conventional antibiotic therapies for urinary tract infection (UTI). The objective of this study was to investigate whether a single aminoglycoside dose adequately treated UTI.: A systematic search of PubMed/MEDLINE and Google Scholar databases was performed through September 2018 for English-language original research articles assessing the efficacy of one-time parenteral aminoglycoside as UTI monotherapy. Read More

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November 2018
12 Reads

Factors associated with hematuric struvite crystalluria in cats.

J Feline Med Surg 2018 Nov 5:1098612X18809176. Epub 2018 Nov 5.

2 Department of Population Medicine, Ontario Veterinary College, Guelph, ON, Canada.

Objectives: The aim of the study was to identify any dietary, signalment, geographic and clinical factors associated with hematuric struvite crystalluria (HSC) in a population of cats that visit general care veterinary hospitals in the USA.

Methods: In total, 4032 cats that had a first-time diagnosis of HSC and 8064 control cats with no history of hematuria or crystalluria were identified from medical records of all cats examined between 2007 and 2011 at 790 US veterinary hospitals. Extracted variables included age, sex, neuter status, breed, diet, urinalysis results and history of cystitis. Read More

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November 2018

Long-term follow-up after cystectomy for bladder pain syndrome: pain status, sexual function and quality of life.

World J Urol 2018 Nov 3. Epub 2018 Nov 3.

Female and Functional Urology Department, Fundació Puigvert, C/Cartagena 340-350, 08025, Barcelona, Spain.

Purpose: To assess the long-term complications, pain status, sexual function and quality of life after cystectomy for bladder pain syndrome (BPS).

Methods: We retrospectively reviewed functional variables for 35 patients (34 women/1 man, 67 ± 9 years old) who underwent cystectomy due to BPS since 1993 in our department. Cystectomy was offered to patients with BPS refractory to conservative treatments. Read More

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November 2018

Investigations of urethral sphincter activity in mice with bladder hyperalgesia before and after drug administration of gabapentin.

Int Urol Nephrol 2018 Nov 1. Epub 2018 Nov 1.

Urology at University of California Irvine, Irvine, CA, USA.

Purpose: This study investigated the effect of gabapentin on lower urinary tract dysfunction focusing on urethral activities and cystitis-induced hyperalgesia in a mouse model of painful bladder syndrome/interstitial cystitis (PBS/IC). The electromyography (EMG) of external urethral sphincter (EUS) was difficult to obtain, but contained useful information to examine the drug effect in mice.

Methods: Female C57BL/6J mice were intraperitoneally (ip) administration with either saline or 200 mg/kg of cyclophosphamide (CYP) 48 h before experimental evaluation. Read More

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November 2018

Decreased antibiotic susceptibility of Enterobacteriaceae causing community-acquired urinary tract infections in French Amazonia.

Med Mal Infect 2018 Oct 29. Epub 2018 Oct 29.

Unité des maladies infectieuses et tropicales, centre hospitalier Andrée-Rosemon, 97300 Cayenne, French Guiana; Équipe EA 3593, écosystèmes amazoniens et pathologie tropicale, université de la Guyane, 97300 Cayenne, French Guiana. Electronic address:

Objectives: Urinary tract infections (UTIs) have rarely been studied in the Amazon region. We aimed to describe the epidemiology of bacteria causing UTIs in French Guiana.

Patients And Methods: We performed a monocenter retrospective study of adults consulting at the emergency department of Cayenne Hospital in 2014 with a diagnosis of UTI. Read More

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October 2018
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Mimickers of urothelial neoplasia.

Ann Diagn Pathol 2018 Sep 26;38:11-19. Epub 2018 Sep 26.

Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Urology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, MD, USA. Electronic address:

Management of malignant urothelial tumors is often associated with extended costly treatments, some with significant morbidity. Advanced tumors are treated with radical cystectomy with neoadjuvant or adjuvant radiation or chemotherapy. Over and under interpretation of histological findings from biopsies and transurethral resections of urothelial lesions may either incur treatments with significant side effects or miss a possible window of cure, respectively. Read More

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September 2018
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