28 results match your criteria Cystitis Nonbacterial

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Cytoprotective effects of glycyrrhetinic acid liposome against cyclophosphamide-induced cystitis through inhibiting inflammatory stress.

Int Immunopharmacol 2018 Jan 11;54:139-144. Epub 2017 Nov 11.

College of Pharmacy, Guangxi Medical University, Nanning 530021, PR China. Electronic address:

This study was designed to investigate the pharmacological efficacy of glycyrrhetinic acid liposome (GAL) against female mice with nonbacterial cystitis induced by cyclophosphamide (CPS). Mice in different groups were subjected to tests for lactate dehydrogenase (LD), cytokine contents (IL-6, TNF-α) in serum, and histological changes in bladder tissue and to immunoassays. As a result, cyclophosphamide-induced cystitis in mice showed an increased LD level in serum, and the contents of cytokines (IL-6, TNF-α) were elevated. Read More

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January 2018

Common Questions About Chronic Prostatitis.

Am Fam Physician 2016 Feb;93(4):290-6

University of British Columbia, Vancouver, British Columbia, Canada.

Chronic prostatitis is relatively common, with a lifetime prevalence of 1.8% to 8.2%. Read More

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February 2016

The role of sodium hyaluronate and sodium chondroitin sulphate in the management of bladder disease.

Ther Adv Urol 2011 Oct;3(5):223-32

Urology Unit, Magna Graecia University of Catanzaro, Viale Europa, Germaneto, Catanzaro 88100, Italy.

Bladder epithelium is not only a simple defence against infections, but it is also a specialized tissue regulating complex bladder functions and playing an active role in the pathogenesis of many bladder diseases. There is strong evidence that different chronic inflammatory bladder diseases, such as recurrent urinary tract infection (UTI), chemical or radiation cystitis and painful bladder syndrome/interstitial cystitis (PBS/IC), can be pathophysiologically linked in the first step of the disease to the loss of the glycosaminoglycan (GAG) mucous layer independently of the original cause of the inflammatory process. The aim of this article is to review the current evidence on the clinic applications of GAGs in urology, with particular emphasis on the therapeutic use of hyaluronic acid (HA) and chondroitin sulphate (CS). Read More

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October 2011

Heart health = urologic health and heart unhealthy = urologic unhealthy: rapid review of lifestyle changes and dietary supplements.

Mark A Moyad

Urol Clin North Am 2011 Aug;38(3):359-67

Department of Urology, University of Michigan Medical Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0330, USA.

Almost all aspects of urology are affected positively and negatively by certain lifestyle changes and dietary supplements. Some of these interventions have potential profound impacts independently or in combination with conventional therapy, others have no impact, and some could negatively impact treatment and overall health. The heart-healthiest recommendations have consistently served as the safest and most potentially effective options in urology from benign prostatic hyperplasia, chronic nonbacterial prostatitis, interstitial cystitis, multiple urologic cancers, male infertility, male and female sexual dysfunction, kidney stones, and Peyronie disease. Read More

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Chronic prostatitis/chronic pelvic pain syndrome and male interstitial cystitis: enigmas and opportunities.

Urology 2007 Apr;69(4 Suppl):60-3

University of Oklahoma Health Science Center-Tulsa, Tulsa, Oklahoma, USA.

Recently, it has been recognized that interstitial cystitis (IC) in males is a more common clinical entity than was previously thought. Further, increasing evidence suggests clinical and pathogenetic similarities between male IC and chronic nonbacterial prostatitis (CP)/chronic pelvic pain syndrome. In this article, we highlight the similarities and differences between male IC and CP and review the presentation, diagnosis, and treatment of IC in men, with particular attention to those who have received an initial diagnosis of CP. Read More

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Interstitial cystitis, chronic nonbacterial prostatitis and chronic pelvic pain syndrome in men: a common and frequently identical clinical entity.

J Urol 2004 Dec;172(6 Pt 2):2561-2

Urologic Specialists of Oklahoma, Inc., St. John Medical Center and The University of Oklahoma Health Science Center-Tulsa, Tulsa, Oklahoma, USA.

Purpose: In this ongoing review we characterize interstitial cystitis in men, identifying multiple clinical factors in the diagnosis and treatment of men with interstitial cystitis.

Materials And Methods: An ongoing and retrospective chart review of 92 men with interstitial cystitis within our large single specialty practice was performed. Presenting complaints, duration of symptoms, epidemiology, and clinical and physical findings were reviewed. Read More

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December 2004

Similarities between interstitial cystitis and male chronic pelvic pain syndrome.

Robert M Moldwin

Curr Urol Rep 2002 Aug;3(4):313-8

Department of Urology, Long Island Jewish Medical Center, 170-5 76th Avenue, New Hyde Park, NY 11040, USA.

Few clinical conditions encountered by the urologist cause more patient and clinician frustration than interstitial cystitis and male chronic pelvic pain syndrome, also know as nonbacterial prostatitis. This frustration is fueled by the chronicity of often disabling urogenital (and often associated systemic) symptoms coupled with delayed care, misdiagnosis, and suboptimal clinical responses. Basic research and therapeutic trials for these syndromes have historically taken two separate paths. Read More

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Cell relationship in a Wistar rat model of spontaneous prostatitis.

J Urol 2001 Jul;166(1):323-8

Department of Comparative Bioscience, University of Wisconsin and Veterans Affairs Medical Center, Madison, Wisconsin, USA.

Purpose: Prostatitis in men is a painful, noninfectious inflammatory condition. It is similar to interstitial cystitis which is associated with increased bladder mast cell and sensory nerve fiber density as well as suprapubic pain. Certain strains of rats may provide a useful model for studies of the development of spontaneous prostatitis. Read More

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[Antimicrobial therapy of urinary tract infections].

Lijec Vjesn 2001 Jan-Feb;123(1-2):16-25

Klinika za infektivne bolesti Dr. Fran Mihaljević, Mirogojska 8, 10000 Zagreb.

Urinary tract infections (UTIs), according to localization of infection, can be subdivided into urethritis, cystitis, prostatitis and pyelonephritis, according to type of infection into symptomatic, asymptomatic, acute (first or single), recurrent, chronic, complicated and uncomplicated. Clinical symptoms of cystitis and leukocyturia are sufficient reason for early initiation of a three-day empirical antimicrobial therapy of acute uncomplicated cystitis in young women. Urine culture should be performed prior to the initiation of antimicrobial therapy in pregnant women, diabetics, recurrent UTIs, in case of unsuccessful prior treatment and in patients with pyelonephritis. Read More

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Sensitivity and specificity of antiproliferative factor, heparin-binding epidermal growth factor-like growth factor, and epidermal growth factor as urine markers for interstitial cystitis.

Urology 2001 Jun;57(6 Suppl 1):9-14

Division of Infectious Diseases, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland, USA.

We previously determined that the urine of interstitial cystitis (IC) patients specifically contains a factor (antiproliferative factor [APF]) that inhibits primary bladder epithelial cell proliferation, and that it has significantly decreased levels of heparin-binding epidermal growth factor-like growth factor (HB-EGF) and increased levels of epidermal growth factor (EGF) compared with urine from asymptomatic controls and patients with bacterial cystitis. We sought to confirm the specificity of these findings for IC using a larger patient population, including control patients with a variety of urogenital disorders. Clean catch urine specimens were collected from 219 symptomatic IC patients, 113 asymptomatic controls without bladder disease, and 211 patients with various urogenital diseases including acute bacterial cystitis, vulvovaginitis, chronic nonbacterial prostatitis, overactive bladder, hematuria, stress incontinence, neurogenic bladder, benign prostatic hyperplasia, bladder or pelvic pain without voiding symptoms, bladder cancer, prostate cancer, or miscellaneous diagnoses including anatomic disorders. Read More

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Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain.

Tech Urol 2001 Mar;7(1):47-9

Department of Urology, University of Pittsburgh School of Medicine, Pennsylvania, USA.

Purpose: Refractory genitourinary pain is a common but difficult condition to treat. Examples of chronic genitourinary pain include orchalgia, interstitial cystitis, pain after bladder suspension surgery, nonbacterial prostatitis, and genital pain related to lumbosacral neuropathy. We report our experience with oral gabapentin treatment for this condition. Read More

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Comorbid clinical conditions in chronic fatigue: a co-twin control study.

J Gen Intern Med 2001 Jan;16(1):24-31

Division of General Internal Medicine, Department of Medicine, University of Washington, Seattle, WA 98104, USA.

Objectives: Chronically fatiguing illness, defined as fatigue for at least 6 months, has been associated with various physical health conditions. Our objective was to determine whether there is a significant relationship between chronically fatiguing illness and 10 clinical conditions that frequently appear to be associated with fatigue, adjusting for the potentially confounding effects of psychiatric illness.

Design: A co-twin control study controlling for genetic and many environmental factors by comparing chronically fatigued twins with their nonfatigued co-twins. Read More

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January 2001

Pentosan polysulfate therapy for chronic nonbacterial prostatitis (chronic pelvic pain syndrome category IIIA): a prospective multicenter clinical trial.

Urology 2000 Sep;56(3):413-7

Department of Urology, Queen's University, Kingston, Ontario, Canada.

Objectives: Chronic nonbacterial prostatitis/chronic pelvic pain syndrome (CPPS) has clinical and perhaps etiologic characteristics similar to interstitial cystitis. Pentosan polysulfate sodium (PPS), an oral medication indicated for the treatment of interstitial cystitis, has shown moderate benefit in reducing chronic pelvic pain and voiding symptoms in patients with interstitial cystitis. We undertook a prospective open-label, multicenter Phase II pilot study to examine the potential efficacy of PPS in the treatment of CPPS in men, using outcome tools validated for CPPS in men. Read More

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September 2000

Prostatitis and urinary tract infection in men: what's new; what's true?

B A Lipsky

Am J Med 1999 Mar;106(3):327-34

University of Washington School of Medicine, and Antibiotic Research Clinic, Veterans Affairs Puget Sound Health Care System, Seattle 98108, USA.

Urinary tract and prostatic infections are common in men, and most are treated by primary providers. Acute bacterial prostatitis is caused by uropathogens, presents with a tender prostate gland, and responds promptly to antibiotic therapy. Chronic bacterial prostatitis is a subacute infection, may present with a variety of pelvic pain and voiding symptoms, and is characterized by recurrent urinary tract infections. Read More

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IL-1ra versus IL-1 levels in prostatic fluid from prostatitis patients.

Urol Int 1998 ;60(2):92-6

Department of Urology, Nippon Medical School, Chiba, Japan.

Recent papers reported that the balance between the production of IL-1ra and IL-1 probably influences the regulation of host responses, the severity and prolongation of the inflammatory reaction in some diseases. Therefore, in our continuing investigation to clarify the significance of leukocytosis and its prolongation in prostatic fluid from prostatitis patients, we investigated whether low levels of IL-1ra versus IL-1 beta secreted in prostatic fluid were the cause of prolonged prostatitis, especially nonbacterial prostatitis (NBP). As a result of the present study, we concluded that a low level of IL-1ra in relation to that of IL-1 secreted in prostatic fluid is unlikely to cause prolongation of NBP for the following reasons: (1) IL-1 beta was detected in 5 of 10 cases (50. Read More

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Tiaprofenic acid. A reappraisal of its pharmacological properties and use in the management of rheumatic diseases.

Drugs 1995 Dec;50(6):1050-75

Adis International Limited, Auckland, New Zealand.

Tiaprofenic acid is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of patients with rheumatic diseases and other clinical conditions of pain and inflammation. Like other propionic acid derivatives, tiaprofenic acid is effective and generally well tolerated. Comparative studies in patients with rheumatoid arthritis or osteoarthritis receiving tiaprofenic acid 600 mg/day demonstrated improvements in pain intensity, duration of morning stiffness, articular index and other clinical variables which were similar to those achieved with alternative NSAIDs. Read More

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December 1995

Prostatodynia and interstitial cystitis: one and the same?

Urology 1995 Apr;45(4):587-90

University of Washington School of Medicine, Seattle, USA.

Objectives: To investigate further the observation that men with prostatodynia may represent a subset of patients with interstitial cystitis.

Methods: The charts of 20 patients with the diagnosis of nonbacterial prostatitis or prostatodynia who underwent cystoscopy and bladder hydrodistention were retrospectively reviewed.

Results: The primary complaint of all 20 patients was genital or rectal pain, or both. Read More

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Effective management of urinary discomfort.

K A Hassay

Nurse Pract 1995 Feb;20(2):36, 39-40, 42-4, passim

Urinary discomfort is the second most common physical complaint affecting women. Although urinary discomfort is commonly a result of inflammation due to bacterial invasion, there are also nonbacterial causes. The development of antimicrobial resistance to bacteria is frequent and costs the patient and the medical community unnecessary time and money. Read More

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February 1995

Macrophages in the urine in acute bacterial cystitis.

Kansenshogaku Zasshi 1993 Jul;67(7):659-64

Department of Urology, Nippon Medical School.

In the previous study in this series of studies concerning the role of macrophages in urinary tract infection, we attempted to detect macrophages in the urine of acute bacterial cystitis patients by nonspecific esterase staining of urinary sediment, however none of the leukocytes stained, probably because of cell damage caused by the urine and by centrifugation. In the present study, detection of macrophages in urine was again attempted, this time by prompt transfer of urinary leukocytes to culture medium after minimum centrifugation, 1 hr culture in a glass bottom chamber and non-specific staining of leukocytes adhering to glass. Macrophages in urine were detected by this method, and they comprised 5. Read More

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Sjögren's syndrome in patients with interstitial cystitis.

J Rheumatol 1993 Jun;20(6):962-6

Department of Immunology, University Hospital Dijkzigt/Erasmus University, Rotterdam, The Netherlands.

Objective: Patients with interstitial cystitis, a chronic nonbacterial inflammation of the bladder, were investigated for the presence of systemic autoimmune diseases, in particular for Sjögren's syndrome (SS).

Methods: Ten patients were included in the study on the basis of a diagnosis of interstitial cystitis according to usual criteria. They underwent clinical and laboratory investigations including those for keratoconjunctivitis (KCS) and focal lymphocytic sialoadenitis (FLS). Read More

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New considerations in treatment of urinary tract infections in adults.

S Faro

Urology 1992 Jan;39(1):1-11

Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.

Urinary tract infections remain some of the most common infections observed in community- and hospital-based practices. Although most infections continue to be caused by enteric bacteria, a growing proportion of these infections are caused by pathogens often associated with sexually transmitted diseases, including those of nonbacterial and viral etiologies. Consequently, multiresistant strains have become more prevalent, and the clinician must respond with a rational approach to therapy, based on the selection of an effective and well-tolerated antibiotic. Read More

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January 1992

Epithelial dysfunction in nonbacterial cystitis (interstitial cystitis).

J Urol 1991 Apr;145(4):732-5

Division of Urology, University of California, San Diego Medical Center.

Traditional concepts of impermeability of the bladder have centered around unique cellular tight junctions and ion pumps. However, recent data from our laboratory have shown that the bladder epithelium in animals and humans relies primarily on its surface glycosaminoglycans to maintain its impermeability. This study demonstrates the first disease associated with an epithelial dysfunction of the bladder, that is a leaky epithelium. Read More

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[Diagnosis of prostatitis in the light of current knowledge].

L Mercz J Bozai

Orv Hetil 1989 May;130(20):1031-5

Authors review the up-to-date questions of the prostatitis diagnostics on the basis of data of nearly 2,000 patients. In case of symptoms indicative of chr. prostatitis it is essential to localise the inflammation to the prostate with laboratory methods and in case of negative finding to identify the organic and functional diseases hidden behind the nonspecific clinical picture. Read More

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Urinary tract infections in the female patient.

C L Parsons

Urol Clin North Am 1985 May;12(2):355-60

Recent investigations into the pathogenesis of urinary tract infections have led to significant understanding of the interaction between uropathogens and the urogenital tract. This understanding provides the potential for the development of new types of therapy. A practical approach to the management of lower urinary tract infections in female patients is discussed, as are new therapies for nonbacterial cystitis, including the urgency-frequency syndrome. Read More

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