1,772 results match your criteria Cystinuria


Outcomes and Long-term Follow-up of Patients with Cystine Stones: a Systematic Review.

Curr Urol Rep 2019 Apr 15;20(6):27. Epub 2019 Apr 15.

Department of Urology, University Hospital Southampton, Southampton, UK.

Purpose Of Review: Cystine stone patients can be difficult to manage with frequent recurrences. We performed a systematic review with a view to assessing interventions, compliance and their long-term outcomes.

Recent Findings: Ten retrospective observational studies (253 patients) assessed the outcomes and long-term follow-up of cystine stone patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11934-019-0891-7DOI Listing

Effect of increasing doses of cystine-binding thiol drugs on cystine capacity in patients with cystinuria.

Urolithiasis 2019 Apr 13. Epub 2019 Apr 13.

Nephrology Division, NYU Langone Medical Center, New York, NY, USA.

Appropriate dosing of cystine-binding thiol drugs in the management of cystinuria has been based on clinical stone activity. When new stones form, the dose is increased. Currently, there is no method of measuring urinary drug levels to guide the titration of therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-019-01128-yDOI Listing

Re: Urine Proteomic Profiling in Patients with Nephrolithiasis and Cystinuria.

Authors:
Dean G Assimos

J Urol 2019 Apr 1:101097JU0000000000000265. Epub 2019 Apr 1.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JU.0000000000000265DOI Listing
April 2019
1 Read

Re: Cystinuria: Genetic Aspects, Mouse Models, and a New Approach to Therapy.

Authors:
Dean G Assimos

J Urol 2019 Mar 13:10109701JU0000554648093076d. Epub 2019 Mar 13.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/01.JU.0000554648.09307.6dDOI Listing

Hypertension and renal impairment in patients with cystinuria: findings from a specialist cystinuria centre.

Urolithiasis 2019 Feb 25. Epub 2019 Feb 25.

Department of Urology, Guy's Hospital, 1st Floor Southwark Wing, Great Maze Pond, London, SE1 9RT, UK.

Higher blood pressures (mean systolic difference 16.8 mmHg) when compared to matched individuals are already reported in patients with calcium urolithiasis. We present the prevalence of hypertension and renal impairment in patients with cystinuria from our specialist single centre. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-019-01110-8DOI Listing
February 2019

Adverse events associated with currently used medical treatments for cystinuria and treatment goals: results from a series of 442 patients in France.

BJU Int 2019 Feb 24. Epub 2019 Feb 24.

Department of Physiology, Functional Renal Explorations Department, AP-HP (Public Assistance Hospitals of Paris), Georges Pompidou European Hospital, Paris Descartes University, Paris, France.

Objective: To evaluate medical treatments, in terms of adverse events (AEs) and therapeutic goals, in a large series of patients with cystinuria.

Patients And Methods: Data from 442 patients with cystinuria were recorded retrospectively. Crystalluria was studied in 89 patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bju.14721DOI Listing
February 2019
3 Reads

Inborn errors of metabolism in the 21 century: past to present.

Ann Transl Med 2018 Dec;6(24):467

Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.

The 21 century is an exciting time to be in the field of metabolic medicine. As with many fields, one of the keys to anticipating the future is to understand the past. The term "inborn error of metabolism" was first coined in 1908 by Sir Archibald Garrod, in reference to four disorders (alkaptonuria, pentosuria, cystinuria and albinism). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/atm.2018.11.36DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6331363PMC
December 2018

Gene therapy for cystinuria.

Urolithiasis 2019 Jan 25. Epub 2019 Jan 25.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Guoxue Xiang#37, Chengdu, 610041, Sichuan, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-019-01111-7DOI Listing
January 2019
5 Reads

Cystinuria in a 13-Month-Old Girl with Absence of Mutations in the SLC3A1 and SLC7A9 Genes.

Authors:
M D Al-Mendalawi

Indian J Nephrol 2018 Nov-Dec;28(6):490

Department of Paediatrics, Al-Kindy College of Medicine, University of Baghdad, Baghdad, Iraq.

View Article

Download full-text PDF

Source
http://www.indianjnephrol.org/text.asp?2018/28/6/490/238188
Publisher Site
http://dx.doi.org/10.4103/ijn.IJN_46_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309381PMC
January 2019
10 Reads

Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones.

Pediatr Nephrol 2019 Jan 4. Epub 2019 Jan 4.

Department of Pediatrics, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON, N6A 5W9, Canada.

Background: The incidence of nephrolithiasis in children and adolescents is increasing and appears to double every 10 years. The most important role of the pediatric nephrologist is to diagnose and modify various metabolic and non-metabolic risk factors, as well as prevent long-term complications especially in the case of recurrent nephrolithiasis.

Objective: The purpose of this review is to summarize the existing literature on the etiology and management of pediatric nephrolithiasis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00467-018-4179-9DOI Listing
January 2019
11 Reads

Urinary proteome in inherited nephrolithiasis.

Urolithiasis 2019 Feb 18;47(1):91-98. Epub 2018 Dec 18.

Chair of Nephrology, Department of Translational Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

In the last decades, proteomics has been largely applied to the Nephrology field, with the double aim to (1) elucidate the biological processes underlying renal diseases; (2) identify disease-specific biomarkers, predictor factors of therapeutic efficacy and prognostic factors of disease progression. Kidney stone disease, and in particular, inherited nephrolithiasis (INL) are not an exception. Given the multifactorial origin of these disorders, the combination of genomics and proteomics studies may complement each other, with the final objective to give a global and comprehensive mechanistic view. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-018-01104-yDOI Listing
February 2019
3 Reads

Amino Acid Transport Across the Mammalian Intestine.

Compr Physiol 2018 12 13;9(1):343-373. Epub 2018 Dec 13.

Research School of Biology, The Australian National University, Canberra, ACT 2601, Australia.

The small intestine mediates the absorption of amino acids after ingestion of protein and sustains the supply of amino acids to all tissues. The small intestine is an important contributor to plasma amino acid homeostasis, while amino acid transport in the large intestine is more relevant for bacterial metabolites and fluid secretion. A number of rare inherited disorders have contributed to the identification of amino acid transporters in epithelial cells of the small intestine, in particular cystinuria, lysinuric protein intolerance, Hartnup disorder, iminoglycinuria, and dicarboxylic aminoaciduria. Read More

View Article

Download full-text PDF

Source
https://onlinelibrary.wiley.com/doi/abs/10.1002/cphy.c170041
Publisher Site
http://dx.doi.org/10.1002/cphy.c170041DOI Listing
December 2018
11 Reads

Urinary metabolic abnormalities in children with idiopathic hematuria.

J Pediatr Urol 2018 Nov 10. Epub 2018 Nov 10.

Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Background: Hematuria, either macroscopic or microscopic, is an incidental finding of multiple nephrologic or urologic disorders. Disturbances of urine inhibitors or promotors have been suggested as the potential causes of isolated idiopathic hematuria in children and its recurrence. Meanwhile, appropriate treatment of these risk factors might improve secondary asymptomatic or macroscopic hematuria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpurol.2018.11.003DOI Listing
November 2018
4 Reads

Urine proteomic profiling in patients with nephrolithiasis and cystinuria.

Int Urol Nephrol 2019 Apr 5;51(4):593-599. Epub 2018 Dec 5.

Nephrology Division, New York University Langone Medical Center, New York, NY, USA.

Purpose: The purpose of the study was to assess the differences in the concentration and function of urinary proteins between patients with cystine stones (CYS) and healthy controls (HC). We postulated that CYS and HC groups would demonstrate different proteomic profiles.

Methods: A pilot study was performed comparing urinary proteomes of 10 patients with CYS and 10 age- and gender-matched HC, using liquid chromatography-mass spectrometry. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11255-018-2044-1
Publisher Site
http://dx.doi.org/10.1007/s11255-018-2044-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461472PMC
April 2019
20 Reads

Cystinuria: genetic aspects, mouse models, and a new approach to therapy.

Urolithiasis 2019 Feb 4;47(1):57-66. Epub 2018 Dec 4.

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, 08854, USA.

Cystinuria, a genetic disorder of cystine transport, is characterized by excessive excretion of cystine in the urine and recurrent cystine stones in the kidneys and, to a lesser extent, in the bladder. Males generally are more severely affected than females. The disorder may lead to chronic kidney disease in many patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-018-1101-7DOI Listing
February 2019
2 Reads

The effect of selenium supplementation on cystine crystal volume in patients with cystinuria.

Biomedicine (Taipei) 2018 Dec 26;8(4):26. Epub 2018 Nov 26.

Isfahan Kidney Transplantation Research Center, Department of Urology, Alzahra Research Centers, Isfahan University of Medical Science, Isfahan, Iran.

Background: Cystinuria as an autosomal recessive sickness is a relatively rare disease. Formation of cystine stones indicates cystinuria. Few studies are considered the cysteine crystal volume in management of cystinuria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1051/bmdcn/2018080426DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6254100PMC
December 2018
16 Reads

Living kidney donation from people at risk of nephrolithiasis, with a focus on the genetic forms.

Urolithiasis 2019 Feb 23;47(1):115-123. Epub 2018 Nov 23.

UOC Nefrologia, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Deciding whether to accept a donor with nephrolithiasis is a multifaceted task because of the challenge of finding enough suitable donors while at the same time ensuring the safety of both donors and recipients. Until not long ago, donors with a history of renal stones or with stones emerging during screening on imaging were not considered ideal, but recent guidelines have adopted less stringent criteria for potential donors at risk of stones. This review goes through the problems that need to be approached to arrive at a wise clinical decision, balancing the safety of donors and recipients with the need to expand the organ pool. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00240-018-1092-4DOI Listing
February 2019
15 Reads

Polymorphism in the PBX1 gene is related to cystinuria in Brazilian families.

J Cell Mol Med 2019 Feb 18;23(2):1593-1597. Epub 2018 Nov 18.

Endourology and Stone Disease Section, Division of Urology, University of Sao Paulo Medical School, Sao Paulo, Brazil.

The aim of our study was to determine regions of loss of heterozygosity, copy number variation analysis, and single nucleotide polymorphisms (SNPs) in Brazilian patients with cystinuria. A linkage study was performed using DNA samples from six patients with cystinuria and six healthy individuals. Genotyping was done with the Genome-Wide Human SNP 6. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/jcmm.13981
Publisher Site
http://dx.doi.org/10.1111/jcmm.13981DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349145PMC
February 2019
17 Reads

An N-Ethyl-N-Nitrosourea (ENU)-Induced Tyr265Stop Mutation of the DNA Polymerase Accessory Subunit Gamma 2 (Polg2) Is Associated With Renal Calcification in Mice.

J Bone Miner Res 2019 Mar 14;34(3):497-507. Epub 2018 Dec 14.

Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

Renal calcification (RCALC) resulting in nephrolithiasis and nephrocalcinosis, which affects ∼10% of adults by 70 years of age, involves environmental and genetic etiologies. Thus, nephrolithiasis and nephrocalcinosis occurs as an inherited disorder in ∼65% of patients, and may be associated with endocrine and metabolic disorders including: primary hyperparathyroidism, hypercalciuria, renal tubular acidosis, cystinuria, and hyperoxaluria. Investigations of families with nephrolithiasis and nephrocalcinosis have identified some causative genes, but further progress is limited as large families are unavailable for genetic studies. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1002/jbmr.3624
Publisher Site
http://dx.doi.org/10.1002/jbmr.3624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446808PMC
March 2019
20 Reads

Renal stones in two children with two rare etiologies.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1203-1206

Department of Pediatric Nephrology, Sheikh Khalifa Medical City, Abu Dhabi, UAE.

The incidence of urolithiasis in children has shown an increase in recent years which may be attributed to changing dietary patterns, sedentary lifestyles, and obesity. Among the various etiologies for renal stones in children, two rare entities worth mentioning are cystinuria and 2, 8-dihydroxyadenine (DHA) urolithiasis. Cystinuria is an inherited cause of nephrolithiasis which occurs due to impaired cystine reabsorption in the renal proximal tubule. Read More

View Article

Download full-text PDF

Source
http://www.sjkdt.org/text.asp?2018/29/5/1203/243955
Publisher Site
http://dx.doi.org/10.4103/1319-2442.243955DOI Listing
November 2018
2 Reads

Amyloid-like Structures Formed by Single Amino Acid Self-Assemblies of Cysteine and Methionine.

ACS Chem Neurosci 2019 Mar 13;10(3):1230-1239. Epub 2018 Nov 13.

Department of Science, School of Technology , Pandit Deendayal Petroleum University , Gandhinagar , Gujarat 382007 , India.

We report for the very first time the discovery of amyloid-like self-assemblies formed by the nonaromatic single amino acids cysteine (Cys) and methionine (Met) under neutral aqueous conditions. The structure formation was assessed and characterized by various microscopic and spectroscopic techniques such as optical microscopy, phase contrast microscopy, scanning electron microscopy, and transmission electron microscopy. The mechanism of self-assembly and the role of hydrogen bonding and thiol interactions of Cys and Met were assessed by Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray diffraction, and solid state NMR along with various control experiments. Read More

View Article

Download full-text PDF

Source
http://pubs.acs.org/doi/10.1021/acschemneuro.8b00310
Publisher Site
http://dx.doi.org/10.1021/acschemneuro.8b00310DOI Listing
March 2019
1 Read
4.362 Impact Factor

No evidence for point mutations in the novel renal cystine transporter AGT1/SLC7A13 contributing to the etiology of cystinuria.

BMC Nephrol 2018 Oct 20;19(1):278. Epub 2018 Oct 20.

Institute of Human Genetics, University Hospital, Technical University RWTH Aachen, Pauwelsstr. 30, D-52074, Aachen, Germany.

Background: Cystinuria is caused by the defective renal reabsorption of cystine and dibasic amino acids, and results in cystine stone formation. So far, mutations in two genes have been identified as causative. The SLC3A1/rBAT gene encodes the heavy subunit of the heterodimeric rBAT-bAT transporter, whereas the light chain is encoded by the SLC7A9/ bAT gene. Read More

View Article

Download full-text PDF

Source
https://bmcnephrol.biomedcentral.com/articles/10.1186/s12882
Publisher Site
http://dx.doi.org/10.1186/s12882-018-1080-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196009PMC
October 2018
11 Reads

Twelve-year-old boy presenting with recurrent abdominal pain and 25 urinary calculi.

Arch Dis Child Educ Pract Ed 2018 Sep 15. Epub 2018 Sep 15.

Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania "Luigi Vanvitelli", Naples, Italy.

: A 12-year-old boy, with intermittent abdominal pain from 3 years of age, presented with increased frequency of right lower quadrant pain (at least three episodes per week over the past six months) and pain during micturition affecting school attendance. His family history included referred urolithiasis. An abdominal ultrasound performed 1 year before our visit showed a small stone of 4 mm in the right renal pelvis for which he did not receive any therapy. Read More

View Article

Download full-text PDF

Source
http://ep.bmj.com/lookup/doi/10.1136/archdischild-2018-31507
Publisher Site
http://dx.doi.org/10.1136/archdischild-2018-315073DOI Listing
September 2018
30 Reads

Simultaneous determination of tiopronin and its primary metabolite in plasma and ocular tissues by HPLC.

Biomed Chromatogr 2019 Feb 26;33(2):e4375. Epub 2018 Sep 26.

Department of Chemistry, Missouri University of Science and Technology, Rolla, MO, USA.

Tiopronin, formally 2-mercaptopropionylglycine (MPG), is currently prescribed to treat cystinuria and rheumatoid arthritis, and its antioxidant properties have led to its investigation as a treatment for cataracts, a condition in which oxidative stress is strongly implicated. To study its accumulation in the eye, a reliable, isocratic HPLC method was developed for the determination of MPG and its primary metabolite 2-mercaptopropionic acid (MPA) in plasma and relevant ocular tissues. This method utilizes pre-column derivatization and fluorescence detection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/bmc.4375DOI Listing
February 2019
22 Reads

Clinical, Biochemical, and Genetic Findings of Cystinuria in Chinese Children.

Clin Lab 2018 Jul;64(7):1145-1151

Background: Cystinuria is a rare inherited renal stone disease caused by mutations in the SLC3A1 and SLC7A9 genes. The Chinese cystinuria phenotype and genotype have rarely been reported in the literature.

Methods: For this research, the clinical features and genetic etiology were analyzed in seven children, and the clinical characteristics were summarized. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.7754/Clin.Lab.2018.180110DOI Listing
July 2018
55 Reads

[Genetic and biochemical features of the monogenic hereditary urolithiasis].

Biomed Khim 2018 Aug;64(4):315-325

Institute of Molecular Medicine of the Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia; Research Centre for Medical Genetics, Moscow, Russia.

Urolithiasis is a common urological problem. In most cases, this multifactorial pathology develops due to the combination of inherited low-penetrance gene variants and environment factors such as urinary tract infections and unbalanced diet. However, some cases are monogenic. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.18097/PBMC20186404315DOI Listing
August 2018
22 Reads

In silico analysis of SLC3A1 and SLC7A9 mutations in Iranian patients with Cystinuria.

Mol Biol Rep 2018 Oct 1;45(5):1165-1173. Epub 2018 Aug 1.

Pediatric Inherited Diseases Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, P.O.Box: 81746-73461, Isfahan, Iran.

Cystinuria is an autosomal recessive defect in reabsorptive transport of cystine and the dibasic amino acids ornithine, arginine, and lysine from renal tubule and small intestine. Mutations in two genes: SLC3A1, encoding the heavy chain rbAT of the renal cystine transport system and SLC7A9, the gene of its light chain b AT have a crucial role in the diseases. In our previous studies from Iranian populations with Cystinuria totally six and eleven novel mutations respectively identified in SLC3A1 and SLC7A9 genes. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11033-018-4269-6
Publisher Site
http://dx.doi.org/10.1007/s11033-018-4269-6DOI Listing
October 2018
23 Reads

Conversion from Cystine to Noncystine Stones: Incidence and Associated Factors.

J Urol 2018 Dec 27;200(6):1285-1289. Epub 2018 Jul 27.

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire; EDGE Consortium. Electronic address:

Purpose: Patients with cystinuria are often treated with medical alkalization and shock wave lithotripsy, although each treatment is hypothesized to increase the risk of calcium phosphate stones. We performed a multicenter retrospective review to evaluate whether stones of another composition develop in patients with cystinuria and with what frequency.

Materials And Methods: We retrospectively reviewed the records of a multi-institutional cohort of patients with cystinuria. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.juro.2018.07.047DOI Listing
December 2018
20 Reads

The impact of surgical intervention on renal function in cystinuria.

J Bras Nefrol 2018 Jul-Sep;40(3):256-260. Epub 2018 Jun 21.

Mersin University Faculty of Medicine, Department of Pediatric Urology, Mersin, Turkey.

Introduction: Cystinuria is an autosomal recessive disorder due to intestinal and renal transport defects in cystine and dibasic amino acids, which result in recurrent urolithiasis and surgical interventions. This study aimed to assess the impact of surgical interventions on renal function by analyzing estimated glomerular filtration rates.

Methods: Thirteen pediatric patients with cystinuria, who were followed-up in a single tertiary institution between 2004 and 2016, were included in the study. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/2175-8239-jbn-2018-0034DOI Listing
June 2018
9 Reads

Causality between myopathic hypotonia-cystinuria syndrome (HCS) and noncompaction (LVHT) is not compelling.

Metab Brain Dis 2018 10 24;33(5):1391. Epub 2018 Jun 24.

2nd Medical Department with Cardiology and Intensive Care Medicine, Krankenanstalt Rudolfstiftung, Vienna, Austria.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11011-018-0270-yDOI Listing
October 2018

[Kidney full of stones, and an adrenal gland not quite normal].

Ann Cardiol Angeiol (Paris) 2018 Jun 19;67(3):219-221. Epub 2018 May 19.

Service d'endocrinologie-diabétologie-maladies métaboliques, l'institut du Thorax, CHU de Nantes, 44093 Nantes cedex 1, France. Electronic address:

A 31-year-old patient was followed for cystinuria, justifying CT scans. In 2006, a tissue mass of 3cm of the right adrenal gland, homogeneous, measured at 3.5cm in 2007 was noted. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ancard.2018.04.019DOI Listing
June 2018
3 Reads

50 Years Ago in The Journal of Pediatrics: The Genetic Basis for the Variability of the Hereditable Diseases.

J Pediatr 2018 05;196:207

Departments of Pediatrics and Oncology Johns Hopkins School of Medicine Baltimore, Maryland.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jpeds.2017.11.032DOI Listing
May 2018
4 Reads

Journey of a cystinuric patient with a long-term follow-up from a medical stone clinic: necessity to be SaFER (stone and fragments entirely removed).

Urolithiasis 2019 Apr 25;47(2):165-170. Epub 2018 Apr 25.

Medical Stone Clinic, University Hospital Southampton NHS Trust, Southampton, UK.

There is a lack of studies looking at the longitudinal follow-up of patients with cystine stones. We wanted to assess the journey of cystinuric patients through our specialist metabolic stone clinic to improve the understanding of episodes, interventions and current outcomes in this patient cohort. After ethical approval, all patients who attended our metabolic stone clinic from 1994 to 2014 with at least one cystine stone episode were included in our study. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s00240-018-1059-5
Publisher Site
http://dx.doi.org/10.1007/s00240-018-1059-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420894PMC
April 2019
7 Reads

A Dynamic Chemical Network for Cystinuria Diagnosis.

Angew Chem Int Ed Engl 2018 Jul 20;57(28):8421-8424. Epub 2018 Apr 20.

Department of Biological Chemistry and Molecular Modeling, IQAC-CSIC, Jordi Girona 18-26, 08034, Barcelona, Spain.

The study of molecular networks represents a conceptual revolution in chemistry. Building on previous knowledge and after understanding the rules of non-covalent interactions, the design of stimulus-responsive chemical systems is possible. Herein we report a new strategy, based on the reorganization of a dynamic chemical network that generates new fluorescent associations in the presence of cysteine or cystine. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/anie.201802189DOI Listing

First cardiac manifestation of hypotonia-cystinuria syndrome.

Metab Brain Dis 2018 08 7;33(4):1375-1379. Epub 2018 Apr 7.

Pediatric Hematology-Oncology Training and Research Hospital, Pediatric Genetic Unit, Ankara, Turkey.

Hypotonia-cystinuria syndrome is a very rare autosomal recessive contiguous gene deletion syndrome of PREPL and SLC3A1 at 2p21 with neuromuscular and neuroendocrinologic presentation. We report a two-year-six-month-old affected female infant and her five-month-old affected brother with a novel homozygous deletion in SLC3A1 and PREPL gene. Both of siblings had mild facial dysmorphism, hypotonia, feeding problems, failure to thrive, developmental delay. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11011-018-0226-2
Publisher Site
http://dx.doi.org/10.1007/s11011-018-0226-2DOI Listing
August 2018
2 Reads

Design, synthesis, and evaluation of l-cystine diamides as l-cystine crystallization inhibitors for cystinuria.

Bioorg Med Chem Lett 2018 05 10;28(8):1303-1308. Epub 2018 Mar 10.

Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, United States. Electronic address:

To overcome the chemical and metabolic stability issues of l-cystine dimethyl ester (CDME) and l-cystine methyl ester (CME), a series of l-cystine diamides with or without N-methylation was designed, synthesized, and evaluated for their inhibitory activity of l-cystine crystallization. l-Cystine diamides 2a-i without N-methylation were found to be potent inhibitors of l-cystine crystallization while N-methylation of l-cystine diamides resulted in derivatives 3b-i devoid of any inhibitory activity of l-cystine crystallization. Computational modeling indicates that N-methylation leads to significant decrease in binding of the l-cystine diamides to l-cystine crystal surface. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.bmcl.2018.03.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5893393PMC

Cystinuria in a 13-month-old Girl with Absence of Mutations in the SLC3A1 and SLC7A9 Genes.

Indian J Nephrol 2018 Jan-Feb;28(1):84-85

Medical Genetics, IRCCS Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/ijn.IJN_20_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5830819PMC

PREVALENCE OF CYSTINURIA IN SERVALS ( LEPTAILURUS SERVAL) IN THE UNITED STATES.

J Zoo Wildl Med 2017 Dec;48(4):1102-1107

Cystinuria is a condition caused by defects in amino acid transport within the kidneys and small intestines. It has been reported in humans, dogs, domestic cats, ferrets, nondomestic canids, and nondomestic felids, including servals ( Leptailurus serval). Genetic mutations have been identified in dogs, humans, and domestic cats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1638/2016-0177.1DOI Listing
December 2017
2 Reads

The Respiratory Induced Kidney Motion: Does It Really Effect the Shock Wave Lithotripsy?

Urol J 2017 01 23;15(1):11-15. Epub 2017 Jan 23.

Department of Urology, Ankara Training and Research Hospital, Ankara, Turkey.

Purpose: To investigate the effect of respiratory induced kidney mobility on success of shock wave lithotripsy (SWL) with an electrohydraulic lithotripter.

Materials And Methods: Between May 2013 and April 2015, 158 patients underwent SWL treatment for kidney stones with an electrohydraulic lithotripter. The exclusion criteria were presence of a known metabolic disease (such as cystinuria), non-opaque stones, need for focusing with ultrasonography, abnormal habitus, urinary tract abnormalities, and inability to tolerate SWL until the end of the procedure. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.22037/uj.v0i0.3774DOI Listing
January 2017
5 Reads

Metabolic investigation in patients with nephrolithiasis.

Einstein (Sao Paulo) 2017 Oct-Dec;15(4):452-456. Epub 2017 Dec 18.

Centro Universitário Faculdade Assis Gurgacz, Cascavel, PR, Brazil.

Objective: To evaluate the prevalence of metabolic disorders associated with nephrolithiasis in a female population.

Methods: A retrospective study on 1,737 patients with evidence of recent formation of renal stones, being 54% females. The laboratory investigation consisted of at least two samples of blood and 24-hour urine to assess calcium, uric acid, citrate and creatinine levels, qualitative cystinuria, urinary pH following fasting and 12-hour water restriction, urine culture, serum creatinine and parathyroid hormone. Read More

View Article

Download full-text PDF

Source
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S
Publisher Site
http://dx.doi.org/10.1590/S1679-45082017AO4029DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5875159PMC
March 2018
7 Reads

The genetic framework for development of nephrolithiasis.

Asian J Urol 2017 Jan 28;4(1):18-26. Epub 2016 Nov 28.

Smith Institute for Urology, Hofstra Northwell School of Medicine, Lake Success, NY, USA.

Over 1%-15% of the population worldwide is affected by nephrolithiasis, which remains the most common and costly disease that urologists manage today. Identification of at-risk individuals remains a theoretical and technological challenge. The search for monogenic causes of stone disease has been largely unfruitful and a technological challenge; however, several candidate genes have been implicated in the development of nephrolithiasis. Read More

View Article

Download full-text PDF

Source
https://linkinghub.elsevier.com/retrieve/pii/S22143882163008
Publisher Site
http://dx.doi.org/10.1016/j.ajur.2016.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5730897PMC
January 2017
15 Reads

Case Study - Case Studies in Cystinuria.

Urol Nurs 2017 Mar-Apr;37(2):90-3

The diagnosis and treatment of patients with rare inherited metabolic disorders associated with recurrent and often obstructive kidney stones are important to the prevention of chronic kidney disease or end stage renal disease. Two case studies in this article describe the diagnosis and management of cystinuria, the most common rare kidney stone disorder. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764755PMC
January 2018
6 Reads

Early Recognition and Management of Rare Kidney Stone Disorders.

Urol Nurs 2017 Mar-Apr;37(2):81-9, 102

Kidney stones, especially those that present in childhood/adolescence, may be due to rare inherited disorders such as cystinuria. Early recognition and prompt treatment can help reduce or even prevent the serious long-term complications of these rare stone disorders. Read More

View Article

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764757PMC
January 2018
15 Reads

Cystinuria: One Possible Reason for Kidney and Salivary Gland Lithiasis Relationship.

J Oral Maxillofac Surg 2018 May 22;76(5):1013-1015. Epub 2017 Nov 22.

Department Head, Aix Marseille University, Marseille, France; Surgery Department-Maxillofacial and Stomatology, Conception University Hospital, Marseille, France; and Laboratoire Parole et Langage, Aix-en-Provence, France.

Salivary gland lithiasis affects 1 to 2% of adults. The submandibular glands are concerned in 87% of cases. An association between kidney and salivary lithiases, although often mentioned, has rarely been observed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.joms.2017.11.005DOI Listing
May 2018
5 Reads

Clinical Outcomes for Cystinuria Patients with Unilateral Versus Bilateral Cystine Stone Disease.

J Endourol 2018 02 3;32(2):148-153. Epub 2018 Jan 3.

1 Department of Urology, University of California , San Francisco, San Francisco, California.

Introduction: Cystinuria is a genetic disorder marked by elevated urinary cystine excretion and recurrent cystine nephrolithiasis. Interestingly, despite seemingly similar contralateral renal anatomy, a subset of cystinuric patients consistently form stones in only one kidney. The aim of this study is to evaluate clinical outcomes in unilateral vs bilateral cystine stone formers. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/end.2017.0335DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813729PMC
February 2018
4 Reads