118,337 results match your criteria Cystic Hygroma Imaging
Dig Surg 2018 Dec 12:1-8. Epub 2018 Dec 12.
Department of General and Pancreatic Surgery, The Pancreas Institute, University of Verona Hospital Trust, Verona,
Background: The prevalence of symptoms in pancreatic cystic neoplasms (PCNs) is mainly based on retrospective surgical series. The aim of this study is to describe the actual prevalence of symptoms in PCNs under surveillance.
Methods: Patients with PCNs under surveillance observed from 2015 to 2017 were submitted to magnetic resonance imaging (MRI) and a specific interview. Read More
Ear Nose Throat J 2018 Dec;97(12):E7-E10
University of Arizona College of Medicine - Tucson, 1501 N. Campbell Ave., PO Box 245017, Tucson, AZ 85724, USA.
Cystic neck masses in the pediatric population are common but rarely concerning for malignancy. Given this typically benign nature, they are frequently managed conservatively. Here we present an unusual case of a waxing and waning cystic neck mass in a pediatric patient. Read More
PLoS One 2018 12;13(12):e0209026. Epub 2018 Dec 12.
Department of Pediatrics, National Jewish Health, Denver, CO, United States of America.
Cystic fibrosis (CF) is the most common life-shortening genetic disease and is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Several current therapies aim at improving availability and/or function of the mutant CFTR proteins. The combination therapeutic lumacaftor/ivacaftor (Orkambi, luma/iva) partially corrects folding and potentiates CFTR function impaired by the F508del mutation. Read More
J Pediatr Gastroenterol Nutr 2018 Dec 11. Epub 2018 Dec 11.
Clinical Pharmacology & Digestive Pathophysiology Unit, Department of Clinical & Experimental Medicine, University of Parma, Parma, Italy.
Vomiting is not only unpleasant for both children and families, but can lead to frequent hospital admission. The persistent vomiting hampers oral intake and increases the risk of dehydration so the proper use of antiemetic drugs can be useful. The pharmacological treatment of vomiting in children remains a challenge for the pediatrician because several antiemetics are prescribed as "off-label", outside their authorized drug label. Read More
Physiol Genomics 2018 Dec 12. Epub 2018 Dec 12.
Department of Pediatrics, Medical College of Wisconsin, United States.
Although cystic fibrosis (CF) is attributed to dysfunction of a single gene, the relationships between the abnormal gene product and development of inflammation and progression of lung disease are not fully understood, limiting our ability to predict an individual patient's clinical course and treatment response. To better understand CF progression, we characterized the molecular signatures of CF disease status using plasma-based functional genomics. Peripheral blood mononuclear cells (PBMCs) from healthy donors were cultured with plasma samples from CF patients (n=103) and unrelated, healthy controls (n=31). Read More
J Water Health 2018 Dec;16(6):1029-1032
Northern Ireland Public Health Laboratory, Department of Bacteriology, Belfast City Hospital, Lisburn Road, Belfast, Northern Ireland, BT9 7AD, UK E-mail: School of Biomedical Sciences, Ulster University, Cromore Road, Coleraine, BT52 1SA, Northern Ireland, UK and Centre for Experimental Medicine, Queen's University, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland, UK.
The frequency of seasonal snowfall results in the transient covering of gardens/amenity sites/open public spaces, which encourages recreational interaction mainly with children. No data is available demonstrating the microbiological composition of such fallen snow and therefore a study was undertaken to examine the microbiology of snow from 37 sites, estimating (i) total viable count (TVC), (ii) identification of bacteria, and (iii) the presence of Pseudomonas aeruginosa. Mean TVC count of 8. Read More
Rev Paul Pediatr 2018 Oct-Dec;36(4):457-465
Programa de Pós-graduação em Saúde da Criança e do Adolescente, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brasil.
Objective: To compare muscle thickness and subcutaneous fat in cystic fibrosis (CF) patients and healthy controls using ultrasonography (US), and to correlate US findings with nutritional, clinical and functional variables.
Methods: Patients aged 6 to 18 years old with a diagnosis of CF and healthy controls were included. Participants underwent anthropometric measurements, an ultrasonographic evaluation of muscle thickness and subcutaneous fat in the triceps, quadriceps, and gastrocnemius regions, and skinfold thickness measurements. Read More
EPMA J 2018 Dec 21;9(4):421-429. Epub 2018 Sep 21.
7Department of Radiology, Keck Medical Center of USC, Los Angeles, CA USA.
Objectives: This study aims to define a radiomic signature for pre-operative differentiation between subclinical pheochromocytoma (sPHEO) and lipid-poor adrenal adenoma (LPA) in adrenal incidentaloma. The goal was to apply a predictive, preventive, and personalized medical approach to the management of adrenal tumors.
Patients And Methods: This retrospective study consisted of 265 consecutive patients (training cohort, 212 (LPA, 145; sPHEO, 67); validation cohort, 53 (LPA, 36; sPHEO, 17)). Read More
Front Endocrinol (Lausanne) 2018 27;9:708. Epub 2018 Nov 27.
Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States.
The hexosamine biosynthetic pathway (HBP) generates the substrate for the O-linked β-N-acetylglucosamine (O-GlcNAc) modification of proteins. The HBP also serves as a stress sensor and has been reported to be involved with nuclear factor of activated T-cells (NFAT) activation, which can contribute to multiple cellular processes including cell metabolism, proliferation, and inflammation. In our previously published report, Fibroblast Growth Factor (FGF) 23, an important endocrine pro-inflammatory mediator, was shown to activate the FGFR4/phospholipase Cγ (PLCγ)/nuclear factor of activated T-cells (NFAT) signaling in chronic inflammatory airway diseases such as cystic fibrosis (CF) and chronic obstructive pulmonary disease (COPD). Read More
Front Pharmacol 2018 27;9:1381. Epub 2018 Nov 27.
Robinson Research Institute, University of Adelaide, Adelaide, SA, Australia.
Cystic fibrosis (CF) is a progressive, chronic and debilitating genetic disease caused by mutations in the CF Transmembrane-Conductance Regulator () gene. Unrelenting airway disease begins in infancy and produces a steady deterioration in quality of life, ultimately leading to premature death. While life expectancy has improved, current treatments for CF are neither preventive nor curative. Read More
Breast Cancer (Dove Med Press) 2018 23;10:177-194. Epub 2018 Nov 23.
University of Medicine and Pharmacy "Carol Davila," Bucharest, Romania,
Background: Triple-negative breast cancer (TNBC) has a poor prognosis, even in its early stages. In the absence of postoperative targeted treatments, intensive adjuvant chemotherapy regimens are proposed. For those favorable histologies, such as apocrine and adenoid cystic carcinoma, which frequently belong to TNBC, aggressive treatments are unnecessary. Read More
J Parasit Dis 2018 Dec 22;42(4):505-510. Epub 2018 Aug 22.
1Laboratory of Agro-physiology, Biotechnology, Environment and Quality, Faculty of Sciences, Ibn Tofail University, BOX 133, 14000 Kenitra, Morocco.
Hydatidosis is considered endemic in Morocco and caused serious health problems in ruminants. The aim of this research is to present an epidemiological study on echinococcosis in sheep. The study was carried out between April 2016 and May 2017. Read More
Am J Gastroenterol 2018 Dec 11. Epub 2018 Dec 11.
Pancreatic Surgery Unit, Humanitas Clinical and Research Center, Milano, Italy.
Introduction: Surveillance programs on high-risk individuals (HRIs) can detect pre-malignant lesions or early pancreatic cancer (PC). We report the results of the first screening round of the Italian multicenter program supported by the Italian Association for the study of the Pancreas (AISP).
Methods: The multicenter surveillance program included asymptomatic HRIs with familial (FPC) or genetic frailty (GS: BRCA1/2, p16/CDKN2A, STK11/LKB1or PRSS1, mutated genes) predisposition to PC. Read More
Respir Care 2018 Dec 11. Epub 2018 Dec 11.
Division of Pediatric Pulmonary and Sleep Medicine, as well as the Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Alabama.
Background: Historically, studies of adherence to airway clearance therapy in cystic fibrosis (CF) have relied on self-reporting. We compared self-reported airway clearance therapy adherence to actual usage data from home high-frequency chest wall compressions (HFCWC) vests and identified factors associated with overestimation of adherence in self-reports.
Methods: Pediatric patients who perform airway clearance therapy with a HFCWC vest were eligible to participate. Read More
J Med Case Rep 2018 Dec 12;12(1):366. Epub 2018 Dec 12.
Department of Dermatology and Venereology, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal.
Background: Abnormal deposition of calcium in the skin or subcutaneous tissue is termed calcinosis cutis. Idiopathic calcinosis cutis of the scrotum is an uncommon entity. The pathogenesis of idiopathic calcinosis cutis of the scrotum is debatable. Read More
Z Orthop Unfall 2018 Dec 11. Epub 2018 Dec 11.
Orthopädie und Traumatologie, Bürgerspital Solothurn, Solothurn, Schweiz.
A ganglion cyst is rarely the cause of peripheral nerve compression. In the lower extremity, it is important to distinguish clinically the symptoms from a radiculopathy. In the literature, neural damage of the peroneal nerve due to a ganglion cyst has been described. Read More
Prenat Diagn 2018 Dec 9. Epub 2018 Dec 9.
Department of Pediatric Imaging, CHU Montpellier, Montpellier, France.
Objective: To assess specific, direct, and indirect prenatal ultrasound features in cases of fetal midgut volvulus.
Methods: Retrospective case series of neonatal volvulus, based on postnatal and prenatal imaging findings that occurred from 2006-2017. Prenatal and postnatal signs including the specific "whirlpool sign" were computed. Read More
Head Neck 2018 Dec 9. Epub 2018 Dec 9.
Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.
Background: Fine-needle aspiration (FNA) cytology has been the standard of care in the workup of cervical lymph nodes (LNs) in patients with recurrent papillary thyroid cancer (PTC) and suspicious cervical LNs. Recently, FNA thyroglobulin (TG) washout measurement has been proposed as an adjunct in the management of these patients. We hypothesize that using FNA-TG washout for suspicious cervical LNs would increase the accuracy of diagnosing metastatic disease especially in cystic and highly vascular cervical LN in patients with recurrent PTC. Read More
Z Geburtshilfe Neonatol 2018 Dec 10;222(6):262-265. Epub 2018 Dec 10.
Obstetrics and Gynecology, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya, Turkey.
A foetal sublingual cystic lesion was diagnosed by routine prenatal ultrasonography at 27 weeks of gestation. Foetal growth and amniotic fluid volume were normal. An ex utero intrapartum treatment (EXIT) procedure was performed, and the cyst was aspirated to allow breathing during planned Caesarean section. Read More
Methods Mol Biol 2019 ;1905:143-153
Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa, Japan.
Inducible pluripotent stem (iPS) cells are multipotent stem cells that are produced by gene transfer of reprogramming factors to somatic cells. They are thought to be an important source of regenerative medicine because of their pluripotency and self-renewal ability. Although the liver has high regeneration ability, continuous death of hepatocytes due to chronic inflammation leads to liver cirrhosis and liver carcinoma. Read More
Neurosurg Rev 2018 Dec 10. Epub 2018 Dec 10.
Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.
The aim of this study is to investigate the clinical presentation and outcomes associated with endoscopic endonasal resection of Rathke cleft cysts (RCCs). The authors retrospectively studied a series of 13 patients who were diagnosed with RCCs after endoscopic endonasal resection at the Second Xiangya Hospital between June 2016 and December 2017. All 13 patients (8 women) underwent a purely endoscopic endonasal approach (EEA) for fenestration and aspiration of RCCs with excision of the cystic wall. Read More
Rev Med Chil 2018 Aug;146(8):933-937
Servicio de Cirugía, Clínica Alemana, Santiago, Chile.
Heterotopic pancreas is a silent gastrointestinal malformation that may become clinically evident when complicated by inflammation and pseudocyst formation. We report a 26 year-old male presenting with vomiting, pain and abdominal distention. An abdominal CT scan showed an important gastric distention secondary to a 4-cm cystic lesion located in the antrum wall. Read More
Rom J Morphol Embryol 2018 ;59(3):839-849
Department of Dental Materials, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania;
Lip cancers account for 10-12% of the total head and neck cancers and, although squamous cell carcinoma is by far the most common lower lip cancer, the basal cell carcinoma (BCC) seems to be more common for the upper lip. Most BCCs have a clinically indolent behavior, but there are also local aggressive and∕or metastatic cases, with the incidence of such cases being estimated at about 1-10% of all cases of BCC. Many of the molecular mechanisms underlying this aggression are still unknown, which is why our study aimed to investigate the potential prognosis of a few markers, such as C-X-C chemokine receptor type 4 (CXCR4), alpha-smooth muscle actin (α-SMA) and Wiskott-Aldrich syndrome like (WASL) in upper lip BCCs. Read More
Med Ultrason 2018 Dec;20(4):541-542
2nd Medical Clinic, UMF Iuliu Hatieganu University, Cluj-Napoca, Romania.
We present the case of a 60-year-old male patient, with refractory ulcers in the groin. Ultrasoundand CT showed a large vascularized tumor of the kidney with cystic parts and inhomogeneous dynamic behaviour. Histology demonstrated Pyoderma gangrenosum (ulcer) and well differentiated adenocarcinoma (kidney). Read More
Front Public Health 2018 26;6:348. Epub 2018 Nov 26.
Center for the Study of Aging, Boise State University, Boise, ID, United States.
Advances in the care and treatment of cystic fibrosis (CF) have led to improved mortality rates; therefore, considerably more individuals with CF are living into adulthood. With an increased number of CF patients advancing into adulthood, there is the need for more research that surrounds the aging adult CF patient. It is important to conduct research and collect results on the aging CF population to help better prepare the CF patient, who is dealing with the heavy treatment and financial burden of their disease, build autonomy and increase their quality of life. Read More
Hum Genome Var 2019 5;6. Epub 2018 Dec 5.
8Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, 187-8551 Japan.
Dandy-Walker malformation (DWM) is a rare congenital malformation defined by hypoplasia of the cerebellar vermis and cystic dilatation of the fourth ventricle. Oligophrenin-1 is mutated in X-linked intellectual disability with or without cerebellar hypoplasia. Here, we report a Japanese DWM patient carrying a novel intragenic 13. Read More
Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.
Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.
Stenotrophomonas maltophilia is an opportunistic pathogen causing airway infection in people with cystic fibrosis (CF). Here, we report the draft genome sequences of two S. maltophilia strains, AU30115 and AU32848, recovered from CF patients. Read More
Arthrosc Tech 2018 Nov 15;7(11):e1149-e1156. Epub 2018 Oct 15.
Advanced Orthopaedics & Sports Medicine, San Francisco, California, U.S.A.
Subchondral lesions are the result of osseous modifications seen in a different array of pathologies such as osteoarthritis, rheumatoid arthritis, calcium pyrophosphate deposition, and osteonecrosis. The physiopathologic changes in all of the aforementioned pathologies are not clear yet. What is clear is that the development of a cystic change in the subchondral bone can cause pain and can lead to modification of the activity of daily life. Read More
Surg Neurol Int 2018 5;9:227. Epub 2018 Nov 5.
Department of Neurosurgery, Iran University of Medical Sciences, Tehran, Iran.
Background: Gliosarcoma (GS) is a primary rare malignant brain tumor that accounts 4% of all high-grade glial tumor of the brain.
Case Description: We present a 45-year-old female admitted to our center with progressive headache since 1 month ago concomitant with nausea and emesis and generalized weakness. Imaging revealed a large solid mass with well-defined margin and some cystic portions that enhanced brightly with contrast. Read More
Case Rep Genet 2018 7;2018:4173704. Epub 2018 Nov 7.
Medical Corps, United States Navy, Pulmonary Department, Naval Medical Center, San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA.
Background: Birt-Hogg-Dubé syndrome is a genetic disorder characterized by skin fibrofolliculomas, cystic lung disease, and bilateral renal tumors. It has also been implicated in the formation of tumors in other organs, particularly thyroid and colon. This case presents a young female presenting with only cystic lung disease and kidney tumors, identified as having a never before identified heterozygous mutation in the folliculin () gene which is the likely cause of her syndrome. Read More
Front Microbiol 2018 23;9:2752. Epub 2018 Nov 23.
Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain.
Multidrug efflux pumps constitute a category of antibiotic resistance determinants that are a part of the core bacterial genomes. Given their conservation, it is conceivable that they present functions beyond the extrusion of antibiotics currently used for therapy. stands as a relevant respiratory pathogen, with a high prevalence at hospitals and in cystic fibrosis patients. Read More
Vet World 2018 Nov 24;11(10):1486-1490. Epub 2018 Oct 24.
Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.
Background And Aim: Cystic echinococcosis, , and liver flukes, such as spp. and , are important parasitic zoonoses, where they able to cause significant veterinary, medical, and economic problems. The present study was carried out to obtain the updated knowledge on the frequency of hydatidosis, fasciolosis, and dicrocoeliosis in the slaughtered sheep and cattle. Read More
Vet World 2018 Nov 8;11(10):1385-1396. Epub 2018 Oct 8.
Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Aim: Human cystic echinococcosis (CE), caused by the larval stage of cestodes, is a globally distributed chronic disease that is an important socioeconomic and public health problem in humans and livestock in developing countries, including Iran. The aim of this study was to determine the overall seroprevalence of hydatid infection in the general population of Iran.
Materials And Methods: This systematic review began by searching electronic databases in English (PubMed, Science Direct, Scopus, and Google Scholar) and Persian (Magiran, Scientific Information Database, Iran Medex, and Iran Doc). Read More
PLoS Pathog 2018 Dec 7;14(12):e1007453. Epub 2018 Dec 7.
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.
Cystic fibrosis (CF) lung infections caused by members of the Burkholderia cepacia complex, such as Burkholderia multivorans, are associated with high rates of mortality and morbidity. We performed a population genomics study of 111 B. multivorans sputum isolates from one CF patient through three stages of infection including an early incident isolate, deep sampling of a one-year period of chronic infection occurring weeks before a lung transplant, and deep sampling of a post-transplant infection. Read More
Ultrasonography 2018 Oct 3. Epub 2018 Oct 3.
Department of Clinical Radiology, Interdisciplinary Ultrasound Center, Ludwig-MaximiliansUniversity of Munich-Grosshadern Campus, Munich, Germany.
Ultrasonography is a generally accepted imaging technique for diagnosing and monitoring cystic renal lesions. The widely used Bosniak classification (I-IV) categorizes renal cystic lesions into five distinctive groups according to ultrasonography and computed tomography (CT) image criteria. For solid renal lesions, determination of vascularity is discriminatory for malignancy in most instances. Read More
Pediatr Infect Dis J 2018 Dec 10. Epub 2018 Dec 10.
MRC Centre for Medical Mycology, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK.
Pancreas 2019 Jan;48(1):e3-e4
Residency Training Program in Internal Medicine Department of Internal Medicine University of Michigan Ann Arbor, MI Division of Gastroenterology and Hepatology Department of Internal Medicine University of Michigan Ann Arbor, MI
Int J Mycobacteriol 2018 Oct-Dec;7(4):358-360
Centre for Experimental Medicine, Queen's University; Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast City Hospital, Northern Ireland, UK.
Background: Antimicrobial resistance (AMR) has rendered certain species of Mycobacterium difficult to treat clinically, particularly the nontuberculous Mycobacterium, Mycobacterium abscessus, in patients with cystic fibrosis (CF). Such patients are treated with several nonantibiotic medicines, which may have antimicrobial properties. Given the growing burden of AMR in M. Read More
J Bacteriol 2018 Dec 10. Epub 2018 Dec 10.
Department of Microbial Pathogenesis, University of Maryland - Baltimore, Baltimore, MD, 21201.
is an opportunistic pathogen, found ubiquitously in the environment and commonly associated with airway infection in patients with cystic fibrosis. strain PAO1 is one of the most commonly used laboratory-adapted research strains and is a standard laboratory-adapted strain in multiple laboratories and strain banks worldwide. Due to potential isolate-to-isolate variability, we investigated the genomic and phenotypic diversity among ten PAO1 strains (henceforth called sublines) obtained from multiple research laboratories and commercial sources. Read More
Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.
B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal, Department of Surgery, Division of CTVS.
Simple bone cyst is a benign lytic lesion usually encountered in children and adolescents. It is a cystic fluid filled lesion which usually involves metaphysis of the long bones. Simple bone cyst of the rib is very rare with only few cases reported in the literature. Read More
Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.
Department Pulmonary and Critical Care Medicine, Lankenau Medical Center. 100 Lancaster Avenue, Wynnewood, PA 19096. Electronic address:
A 49 year old female presented after a respiratory infection with a abnormal chest X-ray demonstrating a cystic calcified mass at the base of the right lung. Chest CT angiogram demonstrated the blood supply arose from the abdominal aorta. This Extralobar sequestration was surgically resected via Video assisted thoracoscopy without complication. Read More
J Pediatr Health Care 2018 Oct 24. Epub 2018 Oct 24.
Cystic fibrosis (CF) is an autosomal recessive genetic disorder resulting from a mutation in the gene which encodes a cellular transmembrane protein channel known as the CF transmembrane conductance regulator. Located systemically on the surface of numerous cells, these altered channels yield multisystem dysfunction. Typical manifestations seen are chronic, progressive, obstructive lung disease, pancreatic insufficiency, CF-related diabetes mellitus, malabsorption and malnutrition, liver disease, and infertility. Read More
J Pediatr (Rio J) 2018 Dec 6. Epub 2018 Dec 6.
Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brazil; Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Laboratório de Fisiologia Pulmonar (LAFIP), Centro de Investigação em Pediatria (CIPED), Campinas, SP, Brazil. Electronic address:
Objective: To compare the values of the markers for volumetric capnography and spirometry and their ability to classify children and adolescents with asthma, cystic fibrosis (CF), and healthy controls.
Methods: This was a cross-sectional study that included 103 patients with controlled persistent allergic asthma, 53 with CF and a healthy control group with 40 volunteers (aged 6-15 years), of both sexes. The individuals underwent volumetric capnography and spirometry. Read More
Int J Pharm 2018 Dec 7. Epub 2018 Dec 7.
INSERM, U 1070, Pôle Biologie Santé, 1 rue Georges Bonnet, TSA 51106, 86073, Poitiers, Cedex 9, France; University of Poitiers, Faculty of Medicine and Pharmacy, 6 rue de la Milétrie, TSA 51115, 86073, Poitiers, Cedex 9, France.
Aerosol antibiotics are an interesting alternative to oral or intravenous therapy in Cystic Fibrosis lung infections. Levofloxacin (LVX) inhaled solution is already an effective option. In this study, the aim was the development of LVX-loaded PLGA microspheres (MS) for pulmonary administration as a dry powder. Read More
HPB (Oxford) 2018 Dec 7. Epub 2018 Dec 7.
Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, VA, USA. Electronic address:
Background: Distal pancreatic neuroendocrine tumors (PNET) and pancreatic cystic neoplasms (PCN) are often incidentally found in older adults, requiring careful consideration between operative management and watchful waiting. This study analyzes the short-term complications associated with distal pancreatectomy (DP) for PNET and PCN in older adults to inform clinical decision-making.
Methods: Patients undergoing DP for PNET and PCN were analyzed using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database and the pancreatectomy procedure-targeted dataset. Read More
World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.
Division of Spine Surgery, Department of Orthopaedics, Alpert Medical School of Brown University; 1 Kettle Point Ave, East Providence, RI. Electronic address:
Background: Cervical squamous cell carcinoma is the second most common cancer in women worldwide, and the third most common cause of female cancer mortality. It frequently metastasizes to the osseous spine and has been rarely reported to cause cutaneous metastases at gynecological surgical scars.
Case Description: A 63-year-old woman with known metastatic cervical squamous cell carcinoma presented with a pathologic fracture of the L2 vertebra, unrelenting back pain, bilateral lower extremity weakness, and inability to ambulate. Read More
Morphologie 2018 Dec 4. Epub 2018 Dec 4.
Département de gynécologie obstétrique et reproduction humaine - CECOS, CHU de Rennes, 16, boulevard de Bulgarie, 35000 Rennes, France; Inserm, université Rennes, EHESP, Irset (Instiut de recherche en santé,environnement et travail)-UMR_S1085, 35000 Rennes, France; Université de Rennes 1, 2, avenue du Pr Léon-Bernard, 35000 Rennes, France. Electronic address:
CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management. Read More
Bioorg Med Chem 2018 Nov 15. Epub 2018 Nov 15.
Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA. Electronic address:
Over-expression of the Hsp70 molecular chaperone prevents protein aggregation and ameliorates neurodegenerative disease phenotypes in model systems. We identified an Hsp70 activator, MAL1-271, that reduces α-synuclein aggregation in a Parkinson's Disease model. We now report that MAL1-271 directly increases the ATPase activity of a eukaryotic Hsp70. Read More
Pancreatology 2018 Nov 27. Epub 2018 Nov 27.
University Medicine Greifswald, Greifswald, Germany.
Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More
J Cyst Fibros 2018 Dec 7. Epub 2018 Dec 7.
Children's Hospital Los Angeles, Pediatric Pulmonology Division, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States. Electronic address:
Genetic counseling for cystic fibrosis (CF) is challenged by intricate molecular mechanisms, complex phenotypes, and psychosocial needs. CFTR variant interpretation has become critical; this manuscript examines variant nomenclature and classes, as well as opportunities and challenges posed by genetic technologies and genotype-directed therapies. With post-graduate training in medical genetics and counseling, genetic counselors educate patients and families, facilitate testing and interpretation, and help integrate genetic information into diagnosis and treatment. Read More