Am J Pathol 2022 Jun 28;192(6):862-875. Epub 2022 Mar 28.
Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia; Georgia Cancer Center, Medical College of Georgia, Augusta University, Augusta, Georgia. Electronic address:
Despite recent advances in understanding the pathogenesis of polycystic kidney disease (PKD), the underlying molecular mechanisms involved in cystogenesis are not fully understood. This study describes a novel pathway involved in cyst formation. Transgenic mice overexpressing netrin-1 in proximal tubular cells showed increased production and urinary excretion of netrin-1. Read More