118,322 results match your criteria Cystic Diseases of the Kidney


[Acute Motor Failure of the N. Peroneus Profundus Caused by a Cystic Tibiofibular Joint].

Z Orthop Unfall 2018 Dec 11. Epub 2018 Dec 11.

Orthopädie und Traumatologie, Bürgerspital Solothurn, Solothurn, Schweiz.

A ganglion cyst is rarely the cause of peripheral nerve compression. In the lower extremity, it is important to distinguish clinically the symptoms from a radiculopathy. In the literature, neural damage of the peroneal nerve due to a ganglion cyst has been described. Read More

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December 2018

Prenatal diagnosis of antenatal midgut volvulus: Specific ultrasound features.

Prenat Diagn 2018 Dec 9. Epub 2018 Dec 9.

Department of Pediatric Imaging, CHU Montpellier, Montpellier, France.

Objective: To assess specific, direct, and indirect prenatal ultrasound features in cases of fetal midgut volvulus.

Methods: Retrospective case series of neonatal volvulus, based on postnatal and prenatal imaging findings that occurred from 2006-2017. Prenatal and postnatal signs including the specific "whirlpool sign" were computed. Read More

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December 2018

Superior detection of metastatic cystic lymphadenopathy in patients with papillary thyroid cancer by utilization of thyroglobulin washout.

Head Neck 2018 Dec 9. Epub 2018 Dec 9.

Division of Endocrine and Oncologic Surgery, Department of Surgery, Tulane University School of Medicine, New Orleans, Louisiana.

Background: Fine-needle aspiration (FNA) cytology has been the standard of care in the workup of cervical lymph nodes (LNs) in patients with recurrent papillary thyroid cancer (PTC) and suspicious cervical LNs. Recently, FNA thyroglobulin (TG) washout measurement has been proposed as an adjunct in the management of these patients. We hypothesize that using FNA-TG washout for suspicious cervical LNs would increase the accuracy of diagnosing metastatic disease especially in cystic and highly vascular cervical LN in patients with recurrent PTC. Read More

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December 2018

Prenatal Diagnosis and Intrapartum Management of Congenital Ranula.

Z Geburtshilfe Neonatol 2018 Dec 10;222(6):262-265. Epub 2018 Dec 10.

Obstetrics and Gynecology, Necmettin Erbakan Universitesi Meram Tip Fakultesi, Konya, Turkey.

A foetal sublingual cystic lesion was diagnosed by routine prenatal ultrasonography at 27 weeks of gestation. Foetal growth and amniotic fluid volume were normal. An ex utero intrapartum treatment (EXIT) procedure was performed, and the cyst was aspirated to allow breathing during planned Caesarean section. Read More

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December 2018

Culture System of Bile Duct-Like Cystic Structures Derived from Human-Inducible Pluripotent Stem Cells.

Methods Mol Biol 2019 ;1905:143-153

Department of Molecular Life Sciences, Tokai University School of Medicine, Isehara, Kanagawa, Japan.

Inducible pluripotent stem (iPS) cells are multipotent stem cells that are produced by gene transfer of reprogramming factors to somatic cells. They are thought to be an important source of regenerative medicine because of their pluripotency and self-renewal ability. Although the liver has high regeneration ability, continuous death of hepatocytes due to chronic inflammation leads to liver cirrhosis and liver carcinoma. Read More

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January 2019

Endoscopic endonasal resection of symptomatic Rathke cleft cysts: clinical outcomes and prognosis.

Neurosurg Rev 2018 Dec 10. Epub 2018 Dec 10.

Department of Neurosurgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China.

The aim of this study is to investigate the clinical presentation and outcomes associated with endoscopic endonasal resection of Rathke cleft cysts (RCCs). The authors retrospectively studied a series of 13 patients who were diagnosed with RCCs after endoscopic endonasal resection at the Second Xiangya Hospital between June 2016 and December 2017. All 13 patients (8 women) underwent a purely endoscopic endonasal approach (EEA) for fenestration and aspiration of RCCs with excision of the cystic wall. Read More

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December 2018

[Gastric intramural pseudocyst in a heterotopic pancreas causing gastric outlet obstruction. Report of one case].

Rev Med Chil 2018 Aug;146(8):933-937

Servicio de Cirugía, Clínica Alemana, Santiago, Chile.

Heterotopic pancreas is a silent gastrointestinal malformation that may become clinically evident when complicated by inflammation and pseudocyst formation. We report a 26 year-old male presenting with vomiting, pain and abdominal distention. An abdominal CT scan showed an important gastric distention secondary to a 4-cm cystic lesion located in the antrum wall. Read More

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The prognostic value of CXCR4, α-SMA and WASL in upper lip basal cell carcinomas.

Rom J Morphol Embryol 2018 ;59(3):839-849

Department of Dental Materials, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania;

Lip cancers account for 10-12% of the total head and neck cancers and, although squamous cell carcinoma is by far the most common lower lip cancer, the basal cell carcinoma (BCC) seems to be more common for the upper lip. Most BCCs have a clinically indolent behavior, but there are also local aggressive and∕or metastatic cases, with the incidence of such cases being estimated at about 1-10% of all cases of BCC. Many of the molecular mechanisms underlying this aggression are still unknown, which is why our study aimed to investigate the potential prognosis of a few markers, such as C-X-C chemokine receptor type 4 (CXCR4), alpha-smooth muscle actin (α-SMA) and Wiskott-Aldrich syndrome like (WASL) in upper lip BCCs. Read More

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January 2018

Abdominal ultrasound in paraneoplastic Pyoderma gangrenosum caused by renal carcinoma.

Med Ultrason 2018 Dec;20(4):541-542

2nd Medical Clinic, UMF Iuliu Hatieganu University, Cluj-Napoca, Romania.

We present the case of a 60-year-old male patient, with refractory ulcers in the groin. Ultrasoundand CT showed a large vascularized tumor of the kidney with cystic parts and inhomogeneous dynamic behaviour. Histology demonstrated Pyoderma gangrenosum (ulcer) and well differentiated adenocarcinoma (kidney). Read More

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December 2018

Evaluation of Food Insecurity in Adults and Children With Cystic Fibrosis: Community Case Study.

Front Public Health 2018 26;6:348. Epub 2018 Nov 26.

Center for the Study of Aging, Boise State University, Boise, ID, United States.

Advances in the care and treatment of cystic fibrosis (CF) have led to improved mortality rates; therefore, considerably more individuals with CF are living into adulthood. With an increased number of CF patients advancing into adulthood, there is the need for more research that surrounds the aging adult CF patient. It is important to conduct research and collect results on the aging CF population to help better prepare the CF patient, who is dealing with the heavy treatment and financial burden of their disease, build autonomy and increase their quality of life. Read More

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November 2018
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A novel intragenic deletion in in a Japanese patient with Dandy-Walker malformation.

Hum Genome Var 2019 5;6. Epub 2018 Dec 5.

8Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, NCNP, Kodaira, Tokyo, 187-8551 Japan.

Dandy-Walker malformation (DWM) is a rare congenital malformation defined by hypoplasia of the cerebellar vermis and cystic dilatation of the fourth ventricle. Oligophrenin-1 is mutated in X-linked intellectual disability with or without cerebellar hypoplasia. Here, we report a Japanese DWM patient carrying a novel intragenic 13. Read More

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December 2018

Draft Genome Sequences of Two Cystic Fibrosis Strains of Stenotrophomonas maltophilia, AU30115 and AU32848.

Microbiol Resour Announc 2018 Sep 20;7(11). Epub 2018 Sep 20.

Department of Microbiology and Molecular Genetics, University of Vermont Larner College of Medicine, Burlington, Vermont, USA.

Stenotrophomonas maltophilia is an opportunistic pathogen causing airway infection in people with cystic fibrosis (CF). Here, we report the draft genome sequences of two S. maltophilia strains, AU30115 and AU32848, recovered from CF patients. Read More

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September 2018

Intraosseous Bioplasty for a Chondral Cyst in the Lateral Tibial Plateau.

Arthrosc Tech 2018 Nov 15;7(11):e1149-e1156. Epub 2018 Oct 15.

Advanced Orthopaedics & Sports Medicine, San Francisco, California, U.S.A.

Subchondral lesions are the result of osseous modifications seen in a different array of pathologies such as osteoarthritis, rheumatoid arthritis, calcium pyrophosphate deposition, and osteonecrosis. The physiopathologic changes in all of the aforementioned pathologies are not clear yet. What is clear is that the development of a cystic change in the subchondral bone can cause pain and can lead to modification of the activity of daily life. Read More

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November 2018

Gliosarcoma with long progression free survival: A case report and literature review.

Surg Neurol Int 2018 5;9:227. Epub 2018 Nov 5.

Department of Neurosurgery, Iran University of Medical Sciences, Tehran, Iran.

Background: Gliosarcoma (GS) is a primary rare malignant brain tumor that accounts 4% of all high-grade glial tumor of the brain.

Case Description: We present a 45-year-old female admitted to our center with progressive headache since 1 month ago concomitant with nausea and emesis and generalized weakness. Imaging revealed a large solid mass with well-defined margin and some cystic portions that enhanced brightly with contrast. Read More

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November 2018

Birt-Hogg-Dubé Syndrome Caused by a Novel Mutation in the FLCL Gene.

Case Rep Genet 2018 7;2018:4173704. Epub 2018 Nov 7.

Medical Corps, United States Navy, Pulmonary Department, Naval Medical Center, San Diego, 34800 Bob Wilson Drive, San Diego, CA 92134, USA.

Background: Birt-Hogg-Dubé syndrome is a genetic disorder characterized by skin fibrofolliculomas, cystic lung disease, and bilateral renal tumors. It has also been implicated in the formation of tumors in other organs, particularly thyroid and colon. This case presents a young female presenting with only cystic lung disease and kidney tumors, identified as having a never before identified heterozygous mutation in the folliculin () gene which is the likely cause of her syndrome. Read More

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November 2018

Role of the Multidrug Resistance Efflux Pump MexCD-OprJ in the Quorum Sensing Response.

Front Microbiol 2018 23;9:2752. Epub 2018 Nov 23.

Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Científicas, Madrid, Spain.

Multidrug efflux pumps constitute a category of antibiotic resistance determinants that are a part of the core bacterial genomes. Given their conservation, it is conceivable that they present functions beyond the extrusion of antibiotics currently used for therapy. stands as a relevant respiratory pathogen, with a high prevalence at hospitals and in cystic fibrosis patients. Read More

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November 2018

An analysis of common foodborne parasitic zoonoses in slaughtered sheep and cattle in Tehran, Iran, during 2015-2018.

Vet World 2018 Nov 24;11(10):1486-1490. Epub 2018 Oct 24.

Department of Food Safety and Hygiene, School of Public Health, Zanjan University of Medical Sciences, Zanjan, Iran.

Background And Aim: Cystic echinococcosis, , and liver flukes, such as spp. and , are important parasitic zoonoses, where they able to cause significant veterinary, medical, and economic problems. The present study was carried out to obtain the updated knowledge on the frequency of hydatidosis, fasciolosis, and dicrocoeliosis in the slaughtered sheep and cattle. Read More

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November 2018

Demographic aspects of human hydatidosis in Iranian general population based on serology: A systematic review and meta-analysis.

Vet World 2018 Nov 8;11(10):1385-1396. Epub 2018 Oct 8.

Toxoplasmosis Research Center, Mazandaran University of Medical Sciences, Sari, Iran.

Aim: Human cystic echinococcosis (CE), caused by the larval stage of cestodes, is a globally distributed chronic disease that is an important socioeconomic and public health problem in humans and livestock in developing countries, including Iran. The aim of this study was to determine the overall seroprevalence of hydatid infection in the general population of Iran.

Materials And Methods: This systematic review began by searching electronic databases in English (PubMed, Science Direct, Scopus, and Google Scholar) and Persian (Magiran, Scientific Information Database, Iran Medex, and Iran Doc). Read More

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November 2018

A genome-wide association analysis reveals a potential role for recombination in the evolution of antimicrobial resistance in Burkholderia multivorans.

PLoS Pathog 2018 Dec 7;14(12):e1007453. Epub 2018 Dec 7.

Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada.

Cystic fibrosis (CF) lung infections caused by members of the Burkholderia cepacia complex, such as Burkholderia multivorans, are associated with high rates of mortality and morbidity. We performed a population genomics study of 111 B. multivorans sputum isolates from one CF patient through three stages of infection including an early incident isolate, deep sampling of a one-year period of chronic infection occurring weeks before a lung transplant, and deep sampling of a post-transplant infection. Read More

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December 2018

Multislice computed tomography/contrast-enhanced ultrasound image fusion as a tool for evaluating unclear renal cysts.

Ultrasonography 2018 Oct 3. Epub 2018 Oct 3.

Department of Clinical Radiology, Interdisciplinary Ultrasound Center, Ludwig-MaximiliansUniversity of Munich-Grosshadern Campus, Munich, Germany.

Ultrasonography is a generally accepted imaging technique for diagnosing and monitoring cystic renal lesions. The widely used Bosniak classification (I-IV) categorizes renal cystic lesions into five distinctive groups according to ultrasonography and computed tomography (CT) image criteria. For solid renal lesions, determination of vascularity is discriminatory for malignancy in most instances. Read More

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October 2018

Immunopathology of Aspergillus Infections in Children with Chronic Granulomatous Disease and Cystic Fibrosis.

Authors:
Adilia Warris

Pediatr Infect Dis J 2018 Dec 10. Epub 2018 Dec 10.

MRC Centre for Medical Mycology, Aberdeen Fungal Group, Institute of Medical Sciences, University of Aberdeen, UK.

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December 2018

Pancreatic Cancer: A Rare Cause of Abdominal Pain in Severe Cystic Fibrosis.

Pancreas 2019 Jan;48(1):e3-e4

Residency Training Program in Internal Medicine Department of Internal Medicine University of Michigan Ann Arbor, MI Division of Gastroenterology and Hepatology Department of Internal Medicine University of Michigan Ann Arbor, MI

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January 2019

Antimycobacterial activity of nonantibiotics associated with the polypharmacy of cystic fibrosis (CF) against mycobacterium abscessus.

Int J Mycobacteriol 2018 Oct-Dec;7(4):358-360

Centre for Experimental Medicine, Queen's University; Department of Bacteriology, Northern Ireland Public Health Laboratory, Belfast City Hospital, Northern Ireland, UK.

Background: Antimicrobial resistance (AMR) has rendered certain species of Mycobacterium difficult to treat clinically, particularly the nontuberculous Mycobacterium, Mycobacterium abscessus, in patients with cystic fibrosis (CF). Such patients are treated with several nonantibiotic medicines, which may have antimicrobial properties. Given the growing burden of AMR in M. Read More

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December 2018

Genomic and phenotypic diversity among ten laboratory isolates of PAO1.

J Bacteriol 2018 Dec 10. Epub 2018 Dec 10.

Department of Microbial Pathogenesis, University of Maryland - Baltimore, Baltimore, MD, 21201.

is an opportunistic pathogen, found ubiquitously in the environment and commonly associated with airway infection in patients with cystic fibrosis. strain PAO1 is one of the most commonly used laboratory-adapted research strains and is a standard laboratory-adapted strain in multiple laboratories and strain banks worldwide. Due to potential isolate-to-isolate variability, we investigated the genomic and phenotypic diversity among ten PAO1 strains (henceforth called sublines) obtained from multiple research laboratories and commercial sources. Read More

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December 2018

Simple Bone Cyst of Rib.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

B.P. Koirala Institute of Health Sciences (BPKIHS), Dharan, Nepal, Department of Surgery, Division of CTVS.

Simple bone cyst is a benign lytic lesion usually encountered in children and adolescents. It is a cystic fluid filled lesion which usually involves metaphysis of the long bones. Simple bone cyst of the rib is very rare with only few cases reported in the literature. Read More

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December 2018

Extralobar Sequestration Complicated by a Cystic Hamartoma in an Adult.

Ann Thorac Surg 2018 Dec 7. Epub 2018 Dec 7.

Department Pulmonary and Critical Care Medicine, Lankenau Medical Center. 100 Lancaster Avenue, Wynnewood, PA 19096. Electronic address:

A 49 year old female presented after a respiratory infection with a abnormal chest X-ray demonstrating a cystic calcified mass at the base of the right lung. Chest CT angiogram demonstrated the blood supply arose from the abdominal aorta. This Extralobar sequestration was surgically resected via Video assisted thoracoscopy without complication. Read More

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December 2018

Cystic Fibrosis: Advancing Along the Continuum.

J Pediatr Health Care 2018 Oct 24. Epub 2018 Oct 24.

Cystic fibrosis (CF) is an autosomal recessive genetic disorder resulting from a mutation in the gene which encodes a cellular transmembrane protein channel known as the CF transmembrane conductance regulator. Located systemically on the surface of numerous cells, these altered channels yield multisystem dysfunction. Typical manifestations seen are chronic, progressive, obstructive lung disease, pancreatic insufficiency, CF-related diabetes mellitus, malabsorption and malnutrition, liver disease, and infertility. Read More

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October 2018

Volumetric capnography versus spirometry for the evaluation of pulmonary function in cystic fibrosis and allergic asthma.

J Pediatr (Rio J) 2018 Dec 6. Epub 2018 Dec 6.

Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Departamento de Pediatria, Campinas, SP, Brazil; Universidade Estadual de Campinas (UNICAMP), Faculdade de Ciências Médicas, Laboratório de Fisiologia Pulmonar (LAFIP), Centro de Investigação em Pediatria (CIPED), Campinas, SP, Brazil. Electronic address:

Objective: To compare the values of the markers for volumetric capnography and spirometry and their ability to classify children and adolescents with asthma, cystic fibrosis (CF), and healthy controls.

Methods: This was a cross-sectional study that included 103 patients with controlled persistent allergic asthma, 53 with CF and a healthy control group with 40 volunteers (aged 6-15 years), of both sexes. The individuals underwent volumetric capnography and spirometry. Read More

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December 2018

Development of levofloxacin-loaded PLGA microspheres of suitable properties for sustained pulmonary release.

Int J Pharm 2018 Dec 7. Epub 2018 Dec 7.

INSERM, U 1070, Pôle Biologie Santé, 1 rue Georges Bonnet, TSA 51106, 86073, Poitiers, Cedex 9, France; University of Poitiers, Faculty of Medicine and Pharmacy, 6 rue de la Milétrie, TSA 51115, 86073, Poitiers, Cedex 9, France.

Aerosol antibiotics are an interesting alternative to oral or intravenous therapy in Cystic Fibrosis lung infections. Levofloxacin (LVX) inhaled solution is already an effective option. In this study, the aim was the development of LVX-loaded PLGA microspheres (MS) for pulmonary administration as a dry powder. Read More

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December 2018

Age-related risks of complications after distal pancreatectomy for neuroendocrine and cystic neoplasms.

HPB (Oxford) 2018 Dec 7. Epub 2018 Dec 7.

Department of Surgery, Virginia Commonwealth University Medical Center, Richmond, VA, USA. Electronic address:

Background: Distal pancreatic neuroendocrine tumors (PNET) and pancreatic cystic neoplasms (PCN) are often incidentally found in older adults, requiring careful consideration between operative management and watchful waiting. This study analyzes the short-term complications associated with distal pancreatectomy (DP) for PNET and PCN in older adults to inform clinical decision-making.

Methods: Patients undergoing DP for PNET and PCN were analyzed using the American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database and the pancreatectomy procedure-targeted dataset. Read More

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December 2018

Cutaneous Metastasis via Surgical Planes Following Lumbar Spinal Reconstruction for Spinal Metastatic Disease.

World Neurosurg 2018 Dec 5. Epub 2018 Dec 5.

Division of Spine Surgery, Department of Orthopaedics, Alpert Medical School of Brown University; 1 Kettle Point Ave, East Providence, RI. Electronic address:

Background: Cervical squamous cell carcinoma is the second most common cancer in women worldwide, and the third most common cause of female cancer mortality. It frequently metastasizes to the osseous spine and has been rarely reported to cause cutaneous metastases at gynecological surgical scars.

Case Description: A 63-year-old woman with known metastatic cervical squamous cell carcinoma presented with a pathologic fracture of the L2 vertebra, unrelenting back pain, bilateral lower extremity weakness, and inability to ambulate. Read More

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December 2018
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Update on the cellular and molecular aspects of cystic fibrosis transmembrane conductance regulator (CFTR) and male fertility.

Morphologie 2018 Dec 4. Epub 2018 Dec 4.

Département de gynécologie obstétrique et reproduction humaine - CECOS, CHU de Rennes, 16, boulevard de Bulgarie, 35000 Rennes, France; Inserm, université Rennes, EHESP, Irset (Instiut de recherche en santé,environnement et travail)-UMR_S1085, 35000 Rennes, France; Université de Rennes 1, 2, avenue du Pr Léon-Bernard, 35000 Rennes, France. Electronic address:

CFTR protein regulates electrolyte and fluid transport in almost all tissues with exocrine function, including male reproductive tract. Mutation of CFTR gene causes cystic fibrosis (CF), which affects the function of several organs, and impairs male fertility. The role of CFTR protein in different compartments of male reproductive tract (testis, epididymis, sperm) as well as an impact of CFTR mutation(s) on male fertility phenotype is discussed in relation with the choice of optimal technique for Assisted Reproductive Techniques (ART) management. Read More

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December 2018

Synthesis and evaluation of esterified Hsp70 agonists in cellular models of protein aggregation and folding.

Bioorg Med Chem 2018 Nov 15. Epub 2018 Nov 15.

Department of Biological Sciences, University of Pittsburgh, A320 Langley Hall, Pittsburgh, PA 15260, USA. Electronic address:

Over-expression of the Hsp70 molecular chaperone prevents protein aggregation and ameliorates neurodegenerative disease phenotypes in model systems. We identified an Hsp70 activator, MAL1-271, that reduces α-synuclein aggregation in a Parkinson's Disease model. We now report that MAL1-271 directly increases the ATPase activity of a eukaryotic Hsp70. Read More

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November 2018

Psychometric evaluation of a patient-reported outcome measure in pancreatic exocrine insufficiency (PEI).

Pancreatology 2018 Nov 27. Epub 2018 Nov 27.

University Medicine Greifswald, Greifswald, Germany.

Background/objectives: Pancreatic exocrine insufficiency (PEI) is commonly caused by chronic pancreatitis (CP) or cystic fibrosis (CF). There are no PEI-specific patient-reported assessments of symptoms and impacts. The PEI Questionnaire (PEI-Q) was developed through qualitative research with PEI patients and expert clinical input. Read More

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November 2018

The increasing challenge of genetic counseling for cystic fibrosis.

J Cyst Fibros 2018 Dec 7. Epub 2018 Dec 7.

Children's Hospital Los Angeles, Pediatric Pulmonology Division, Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, United States. Electronic address:

Genetic counseling for cystic fibrosis (CF) is challenged by intricate molecular mechanisms, complex phenotypes, and psychosocial needs. CFTR variant interpretation has become critical; this manuscript examines variant nomenclature and classes, as well as opportunities and challenges posed by genetic technologies and genotype-directed therapies. With post-graduate training in medical genetics and counseling, genetic counselors educate patients and families, facilitate testing and interpretation, and help integrate genetic information into diagnosis and treatment. Read More

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December 2018

Depletion of BAFF cytokine exacerbates infection in Pseudomonas aeruginosa infected mice.

J Cyst Fibros 2018 Dec 7. Epub 2018 Dec 7.

Department of Human Genetics, McGill University, Montreal, Quebec, Canada; Program in Infectious Diseases and Immunity in Global Health, McGill University Health Center, Montreal, Quebec, Canada. Electronic address:

Background: Cystic fibrosis (CF) is a genetic disease characterized by chronic inflammation of the lungs that is ineffective at clearing pathogens. B-cell activating factor (BAFF), a cytokine involved in the development of B-cells, is known to be elevated in CF patients with subclinical infections. We postulate that the elevated BAFF levels in CF patients might be triggered by Pseudomonas aeruginosa infection and it might play a protective role in the regulation of lung responses to infection. Read More

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December 2018

Pathogenesis of endometriosis: the genetic/epigenetic theory.

Fertil Steril 2018 Dec 6. Epub 2018 Dec 6.

School of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, and Virginia Commonwealth University, Richmond, Virginia.

Objective: To study the pathophysiology of endometriosis.

Design: Overview of observations on endometriosis.

Setting: Not applicable. Read More

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December 2018

The value of MR-detectable ipsilateral ovaries in characterizing the origin and malignancy of an adnexal tumors.

Eur J Radiol 2018 Dec 26;109:62-67. Epub 2018 Oct 26.

Department of Radiology, Jinshan Hospital, Fudan University, 1508 Longhang Road, Shanghai 201508, China. Electronic address:

Objective: To investigate the magnetic resonance (MR) imaging morphological relationship between adnexal tumors and the ipsilateral ovaries to characterize the origin and malignancy of tumors.

Material And Methods: Clinical and MR imaging data of 496 adnexal tumors confirmed by histology (ovary tumors, n = 400, non-ovarian tumors, n = 96; benign tumors, n = 183, borderline tumors, n = 120, and malignant tumors, n = 193) were retrospectively analyzed. The presence and shape of the ipsilateral ovaries within the context of adnexal tumors of different origins, malignancies and configurations were evaluated. Read More

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December 2018
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Preoperative discrimination of tumour stage in clear cell carcinoma of the ovary using computed tomography and magnetic resonance imaging.

Eur J Radiol 2018 Dec 22;109:19-26. Epub 2018 Oct 22.

Department of Radiology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.

Objectives: Clear cell carcinoma (CCC) of the ovary shows distinct clinical characteristics depending on the stage. We aimed to investigate the imaging predictability for tumour stage in CCC.

Patients And Methods: Fifty-six tumours in 48 patients with pathologically proven CCC were enrolled. Read More

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December 2018

UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.

Oral Oncol 2018 Dec 18;87:21-28. Epub 2018 Oct 18.

Department of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI, USA; Department of Otolaryngology, University of Michigan School of Medicine, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Objectives: Limited availability of validated human adenoid cystic carcinoma (ACC) cell lines has hindered the mechanistic understanding of the pathobiology of this malignancy and the development of effective therapies. The purpose of this work was to generate and characterize a human ACC cell line.

Material And Methods: Immediately after surgery, a tumor fragment from a minor salivary gland from the tongue of a female Caucasian was minced, dissociated, and a single cell suspension was plated in fibronectin-coated flasks. Read More

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December 2018

Human papillomavirus-related multiphenotypic sinonasal carcinoma: An emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour.

Oral Oncol 2018 Dec 16;87:17-20. Epub 2018 Oct 16.

Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA. Electronic address:

Human papillomavirus (HPV) is well established as a causative factor in most squamous cell carcinomas of the oropharynx (OPSCC). Indeed, a growing awareness over the past two decades that HPV-OPSCC is a distinct form of head and neck cancer has had a profound impact on diagnostic and clinical practices. The sinonasal tract is a second anatomic "hot spot" for HPV-related head and neck carcinomas, but certain pathologic features and the clinical behavior of HPV-related carcinomas at this site remain unclear. Read More

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December 2018

Clinical, pathological and treatment factors associated with the survival of patients with primary pulmonary salivary gland-type tumors.

Lung Cancer 2018 Dec 10;126:174-181. Epub 2018 Nov 10.

Department of Medical Oncology, Changzheng Hospital, Naval Medical University, Shanghai, 200072, China. Electronic address:

Introduction: Primary pulmonary salivary gland-type tumors (p-SGTs) are rare, with poorly understood clinicopathological characteristics and survival. There are only few case reports or small case series, and factors associated with survival need to be identified.

Methods: A population cohort study was conducted using data from patients with histologically diagnosed primary p-SGTs in the Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2013. Read More

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December 2018

[Magnetic resonance imaging findings and differential diagnosis of renal epithelioid angiomyolipoma comparing with renal no-epithelioid angiomyolipoma].

Zhonghua Yi Xue Za Zhi 2018 Dec;98(45):3701-3704

Department of X-ray, the Affiliated Chinese Medical Hospital of Southwest Medical University, Luzhou 646300, China.

To investigate whether MRI findings can differentiate renal epithelioid angiomyolipoma (EAML) from renal no-epithelioid (typical) angiomyolipoma. A total of 44 patients were collected from General Hospital of PLA.These cases were obtained from January 2009 to June 2015. Read More

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December 2018

Development and Validation of a Copro-Enzyme-Linked Immunosorbent Assay Sandwich for Detection of -Soluble Membrane Antigens in Dogs.

Am J Trop Med Hyg 2018 Dec 10. Epub 2018 Dec 10.

Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Perú.

Cystic echinococcosis (CE) is a parasitic zoonosis caused by the larval stage of the tapeworm . Detection of the adult stage in the canine definitive host is essential for estimating infection rates, surveillance and monitoring of CE control programs. This study sought to develop and validate a coproantigen sandwich enzyme-linked immunosorbent assay (copro-ELISA), based on antibodies against -soluble membrane antigens (EGMA), that is capable of distinguishing infected and noninfected dogs. Read More

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December 2018

Genome-wide DNA methylation profiling shows a distinct epigenetic signature associated with lung macrophages in cystic fibrosis.

Clin Epigenetics 2018 Dec 10;10(1):152. Epub 2018 Dec 10.

Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.

Background: Lung macrophages are major participants in the pulmonary innate immune response. In the cystic fibrosis (CF) lung, the inability of lung macrophages to successfully regulate the exaggerated inflammatory response suggests dysfunctional innate immune cell function. In this study, we aim to gain insight into innate immune cell dysfunction in CF by investigating alterations in DNA methylation in bronchoalveolar lavage (BAL) cells, composed primarily of lung macrophages of CF subjects compared with healthy controls. Read More

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December 2018

Real-time Electrochemical Detection of Pseudomonas aeruginosa Phenazine Metabolites using Transparent Carbon Ultramicroelectrode Arrays.

ACS Sens 2018 Dec 10. Epub 2018 Dec 10.

Here, we use a recently developed electrochemical sensing platform of transparent carbon ultramicroelectrode arrays (T-CUAs) for the in vitro detection of phenazine metabolites from the opportunistic human pathogen Pseudomonas aeruginosa. Specifically, redox-active metabolites pyocyanin (PYO), 5-methylphenazine-1-carboxylic acid (5-MCA) and 1-hydroxyphenazine (OHPHZ) are produced by P. aeruginosa, which is commonly found in chronic wound infections and in the lungs of cystic fibrosis patients. Read More

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December 2018

A giant sacrococcygeal teratoma in adult female: A case report.

Int J Surg Case Rep 2018 Nov 22;54:47-50. Epub 2018 Nov 22.

Department of General Surgery, King Abdulla University Hospital, Faculty of Medicine, Jordan University of Science and Technology, P.O. Box (3030), Irbid, 22110, Jordan. Electronic address:

Introduction: Sacrococcygealteratoma is very rare in adults with only few cases reported in literature. It is a slow growing benign cystic tumor with 1-2% chance for malignant transformation and may attain a huge size causing pressure effect on pelvic and intra-abdominal organs. When grows caudally, it causes discomfort, skin excoriation and cosmetic disfigurement. Read More

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November 2018
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Vaccines for preventing invasive salmonella infections in people with sickle cell disease.

Cochrane Database Syst Rev 2018 Dec 5;12:CD006975. Epub 2018 Dec 5.

Department of Paediatrics, University of Calabar Teaching Hospital, PMB 1115, Calabar, Cross River State, Nigeria, 540261.

Background: Salmonella infections are a common bacterial cause of invasive disease in people with sickle cell disease especially children, and are associated with high morbidity and mortality rates. Although available in some centres, people with sickle cell anaemia are not routinely immunized with salmonella vaccines. This is an update of a previously published Cochrane Review. Read More

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December 2018
5 Reads

Gut microbiota signatures in cystic fibrosis: Loss of host CFTR function drives the microbiota enterophenotype.

PLoS One 2018 6;13(12):e0208171. Epub 2018 Dec 6.

Unit of Human Microbiome, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy.

Background: Cystic fibrosis (CF) is a disorder affecting the respiratory, digestive, reproductive systems and sweat glands. This lethal hereditary disease has known or suspected links to the dysbiosis gut microbiota. High-throughput meta-omics-based approaches may assist in unveiling this complex network of symbiosis modifications. Read More

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December 2018
2 Reads

GLUT3 expression in cystic change induced by hypoxia in pituitary adenomas.

Endocr Connect 2018 Dec 1. Epub 2018 Dec 1.

S Wang, Neurosurgery, Fuzhou General Hospital, Fuzhou, China., Fuzhou, China.

Tumor cells require large amounts of energy to sustain growth. Through the mediated transport of glucose transporters, the uptake and utilization of glucose by tumor cells are significantly enhanced in the hypoxic microenvironment. Pituitary adenomas are benign tumors with high energy metabolisms. Read More

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December 2018
1 Read