9,510 results match your criteria Cystectomy Radical


A systematic review of nerve grafting, end-to-end repair, and nerve transfer for obturator nerve injuries.

Int J Gynecol Cancer 2022 Aug 10. Epub 2022 Aug 10.

Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

Objective: Obturator nerve injury can occur as a complication of gynecologic surgeries, occurring most frequently in patients with endometriosis and genitourinary malignancies. The resulting injury causes paresthesia and major weakness in adduction and atrophy of the adductor group of lower extremity muscles. The objective of this study was to conduct a systematic review and meta-analysis of the effectiveness of end-to-end repair, nerve grafting, and nerve transfer in improving motor function in patients with obturator nerve injury. Read More

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Robotic-assisted, laparoscopic, and open radical cystectomy: surgical data of 1400 patients from The Italian Radical Cystectomy Registry on intraoperative outcomes.

Cent European J Urol 2022 4;75(2):135-144. Epub 2022 May 4.

Oncological Urology, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy.

Introduction: The Italian Radical Cystectomy Registry (Registro Italiano Cistectomie - RIC) aimed to analyse outcomes of a multicenter series of patients treated with radical cystectomy (RC) for bladder cancer.

Material And Methods: An observational, prospective, multicenter, cohort study was performed to collect data from RC and urinary diversion via open (ORC), laparoscopic (LRC), or robotic-assisted (RARC) techniques performed in 28 Italian Urological Departments. The enrolment was planned from January 2017 to June 2020 (goal: 1000 patients), with a total of 1425 patients included. Read More

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Current thromboprophylaxis in urological cancer patients during COVID-19 pandemic.

Cent European J Urol 2022 14;75(2):128-134. Epub 2022 Apr 14.

Department of Urology and Andrology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Poland.

Introduction: Venous thrombosis is a well-known complication of cancer disease, especially in Urology. However, even though proper antithrombotic prophylaxis is crucial in most urological procedures, we have insufficient high-quality studies on this topic. The European Association of Urology (EAU) Guidelines are outdated and lack data on COVID-19 increased risk of thrombosis. Read More

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Outcomes and Prognostic Factors of Patients with Urothelial Carcinoma Undergoing Radical Cystectomy and pT0 in the Final Histology Without Neoadjuvant Chemotherapy.

Res Rep Urol 2022 1;14:281-290. Epub 2022 Aug 1.

Department of Urology, Klinikum der Universität München, Munich, Germany.

Purpose: Absence of tumor in the final histopathology after radical cystectomy (RC) is a rare but potentially favorable outcome. Therefore, we aimed to analyze outcomes and prognostic factors of patients with urothelial carcinoma (UC) undergoing RC and T0 in the final histology without neoadjuvant chemotherapy at a high-volume academic center.

Patients And Methods: We retrospectively analyzed patients undergoing RC for pure UC between 2004 and 2020. Read More

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Neoadjuvant Treatment in Muscle-Invasive Bladder Cancer: From the Beginning to the Latest Developments.

Front Oncol 2022 22;12:912699. Epub 2022 Jul 22.

Department of Health Sciences, University of Florence, Florence, Italy.

Urothelial carcinoma of the bladder is one of the most prevalent cancers worldwide, diagnosed as muscle invasive in 25% of cases. Although several studies have demonstrated an overall 5% absolute survival benefit at 5 years with cisplatin-based combination neoadjuvant treatment, administration of chemotherapy prior to radical cystectomy (RC) in muscle-invasive bladder cancer (MIBC) patients is still a matter of debate. This may be due to the perceived modest survival benefit, cisplatin-based chemotherapy ineligibility, or fear of delaying potentially curative surgery in non-responders. Read More

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Diffusion of robot-assisted radical cystectomy: Nationwide trends, predictors, and association with continent urinary diversion.

Arab J Urol 2022 16;20(3):159-167. Epub 2022 Feb 16.

Department of Urology, University of Texas (UT) Health, San Antonio, TX, USA.

Objectives: To assess the utilisation trends of robot-assisted radical cystectomy (RARC), rates of performing continent urinary diversions (CUDs), and impact of diffusion of RARC on CUD rates.

Methods: We investigated the National Cancer Database for patients with muscle-invasive bladder cancer (MIBC) who underwent RC between 2004 and 2015. Patients were stratified by surgical technique into open (ORC) and RARC groups, and by type of urinary diversion into continent (CUD) and ileal conduit (ICUD) groups. Read More

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February 2022

Practice trends for perioperative intravesical chemotherapy in upper tract urothelial carcinoma: Low but increasing utilization during minimally invasive nephroureterectomy.

Urol Oncol 2022 Aug 4. Epub 2022 Aug 4.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX. Electronic address:

Introduction: Perioperative intravesical chemotherapy (IVC) at or around the time of radical nephroureterectomy (RNU) reduces the risk of intravesical recurrence. Guidelines since 2013 have recommended its use. The objective of this study is to examine IVC utilization and determine predictors of its administration within a large international consortium. Read More

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Re: Effect of Robot-assisted Radical Cystectomy with Intracorporeal Urinary Diversion vs Open Radical Cystectomy on 90-Day Morbidity and Mortality Among Patients with Bladder Cancer: A Randomized Clinical Trial.

Eur Urol 2022 Aug 3. Epub 2022 Aug 3.

School of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Second Department of Urology, Sismanogleio Hospital, Athens, Greece. Electronic address:

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Phase 1 Study of Chemoradiotherapy Combined with Nivolumab ± Ipilimumab for the Curative Treatment of Muscle-invasive Bladder Cancer.

Eur Urol 2022 Aug 3. Epub 2022 Aug 3.

Cancer Center Amsterdam, Amsterdam, The Netherlands; Department of Medical Oncology, Amsterdam UMC location University of Amsterdam, Amsterdam, The Netherlands. Electronic address:

Background: Muscle-invasive bladder cancer (MIBC) has a poor prognosis. Chemoradiotherapy (CRT) in selected patients has comparable results to radical cystectomy. Results of neoadjuvant immune checkpoint inhibitors (ICIs) before radical cystectomy are promising. Read More

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Predictive Value of the Log Odds of Negative Lymph Nodes/T Stage as a Novel Prognostic Factor in Bladder Cancer Patients After Radical Cystectomy.

Front Oncol 2022 19;12:895413. Epub 2022 Jul 19.

Department of Urology, the First Affiliated Hospital of Nanchang University, Nanchang City, China.

Background: The effect of lymph node resection on the prognosis of bladder cancer (BLCA) patients receiving radical cystectomy should not be ignored. Our aim was to explore the prognostic value of the log odds of negative lymph nodes/T stage (LONT) and construct a more effective nomogram based on LONT to predict cancer-specific survival (CSS) in postoperative BLCA patients.

Methods: Patients diagnosed with BLCA after radical cystectomy between 2004 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were enrolled. Read More

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[Immunological biomarker research in uro-oncology-using the example of urothelial cancer].

Authors:
Markus Eckstein

Urologie 2022 Jul 30;61(7):734-738. Epub 2022 May 30.

Institut für Pathologie, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Krankenhausstr. 8-10, 91052, Erlangen, Deutschland.

The most common malignant tumor of the urinary tract system is urothelial carcinoma (UC). With the introduction of novel immunologic therapy options in both metastatic and localized settings, the exploration of immunologic biomarkers to predict potential treatment success has become a focus of clinical translational research. For example, expression levels of programmed cell death ligand 1 (PD-L1) in UC tumors can help clinicians decide which patients are more likely to respond to immuno-oncology therapies; in light of new approvals with mandated PD-L1 testing (e. Read More

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[Quality assurance for the treatment of muscle-invasive and metastasized bladder carcinoma in Germany : An initiative of the Working Groups Urological Oncology (AUO) and Internal Oncology (AIO) in the German Cancer Society (DKG)].

Urologie 2022 Jun 29. Epub 2022 Jun 29.

Klinik für Innere Medizin, Hämatologie, Onkologie und Palliativmedizin, Vivantes Klinikum Neukölln, Berlin, Deutschland.

Background: The S3-guideline on bladder cancer recommends radical cystectomy and cisplatin-based perioperative chemotherapy (POC) for muscle-invasive bladder cancer (MIBC). Recommendation for metastatic urothelial cancer (mUC) is cisplatin-based or immuno-oncological (IO) treatment in platinum-ineligible patients (pts) or as 2nd-line therapy.

Objectives: Aim of the study was to obtain representative data on clinical routine treatment of MIBC and mUC in Germany. Read More

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How Does the COVID-19 Pandemic Influence Histopathological Outcomes for Urologic Cancers?

Cureus 2022 Jul 1;14(7):e26500. Epub 2022 Jul 1.

Urology, Ege University Faculty of Medicine, Izmir, TUR.

Objective:  The coronavirus disease 2019 (COVID-19) pandemic disrupted all routine health care services and resulted in a significant reconfiguration of urologic cancer services and care pathways across the globe. This study aimed to retrospectively determine the pandemic's impact on the urologic oncological surgery outcomes at a high-volume referral center.

Materials And Methods: We compared the number and histopathological outcomes of urologic oncological procedures in a referral center coded during the pandemic and data of the period before the pandemic as control. Read More

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Radical cystectomy and women's sexual health - can we do better?

Curr Opin Urol 2022 Sep;32(5):545-553

Department of Urology, LSU Health Science Center - New Orleans, New Orleans, Louisiana.

Purpose Of Review: Female sexual function after radical cystectomy is a crucial, but historically overlooked component of bladder cancer survivorship. This review focuses on recent studies, which have investigated pelvic health and sexual function after radical cystectomy. We discuss modifiable factors, which may contribute to decreased sexual function after radical cystectomy and techniques, which may lead to improved outcomes. Read More

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September 2022

Value of Geriatric Assessment Using the G8 to Predict Postoperative Urinary Tract Infections in Patients Undergoing Radical Cystectomy.

Turk J Urol 2022 Jul;48(4):278-286

Department of Urology, National Cancer Center Hospital East, Chiba, Japan.

Objective: Urinary tract infection is one of the most common and distressing complications of radical cystectomy with urinary diversion. This study aimed to elucidate the usefulness of the geriatric-8 screening tool for predicting postoperative complications, especially urinary tract infections, in patients who underwent radical cystectomy with urinary diversion.

Material And Methods: Ninety-one patients with bladder cancer who underwent radical cystectomy with urinary diversion were assessed for geriatric-8 and classified into 3 groups according to their geriatric-8 score: 14 as the high score group. Read More

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Neoadjuvant and Adjuvant Chemotherapy for Variant Histology Bladder Cancers: A Systematic Review and Meta-Analysis.

Front Oncol 2022 14;12:907454. Epub 2022 Jul 14.

Department of Urology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, JinHua, China.

Context: To improve the prognosis of variant histology (VH) bladder cancers, clinicians have used neoadjuvant chemotherapy (NAC) or adjuvant chemotherapy (AC) on the basis of radical cystectomy (RC). Despite some new data, the evidence remains mixed on their efficacy.

Objective: To update the current evidence on the role of NAC and AC for VH bladder cancers. Read More

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Impact of an inpatient advanced practice provider on hospital length of stay after major urologic oncology procedures.

Urol Oncol 2022 Jul 25. Epub 2022 Jul 25.

Penn State Health Milton S. Hershey Medical Center,  Hershey, PA. Electronic address:

Introduction: Although timely hospital discharge is a complex and multifactorial process, this metric is consistently a focus for hospitals and health care systems. It also has been a long practice that the American Urological Association (AUA) supports the use of advanced practice providers (APPs) as an integral member of the urological care team.

Materials And Methods: Here, we performed a preliminary evaluation of the effectiveness of an inpatient APP in reducing hospital length of stay (LOS) following major urologic oncology procedures. Read More

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The rate of prostatic involvement in men treated with radical cystectomy for muscle invasive bladder cancer.

Pract Radiat Oncol 2022 Jul 25. Epub 2022 Jul 25.

Department of Oncology, Division of Radiation Oncology, McGill University.

Purpose: Radical cystoprostatectomy (RC) is one standard treatment for muscle-invasive bladder cancer (MIBC) in male patients. Another therapeutic option is trimodal therapy (TMT). Including the prostate in the TMT radiotherapy volume is based on MIBC surgical series showing prostatic stromal (PS) involvement. Read More

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Is it necessary to perform a retrosigmoid transposition of the left ureter in Bricker Ileal Conduit surgery?

BMC Urol 2022 Jul 27;22(1):116. Epub 2022 Jul 27.

Department of Urology, Second Affiliated Hospital of Anhui Medical University, No. 678 Furong Road, Hefei, 200032, People's Republic of China.

Background: The need for the left ureter to pass through the subsigmoid during ileal conduit diversion surgery has not been investigated in any studies. A modified technique is simply used in the ileal conduit with the left ureter straight over the sigmoid colon due to the possible damage and lack of scientifically validated advantages of this procedure. Our study aimed to investigate the feasibility of the suggested surgical technique, as well as to evaluate perioperative outcomes and postoperative complications with a focus on the prevalence of small bowel obstruction (SBO) and ureteroileal anastomotic stricture (UAS). Read More

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Arterioureteral fistula after radical cystectomy and ureterocutaneostomy: two case reports and a systematic literature review.

BMC Urol 2022 Jul 27;22(1):117. Epub 2022 Jul 27.

Department of Urology, Qilu Hospital of Shandong University, Jinan, 250012, Shandong Province, People's Republic of China.

Background: Arterioureteral fistula (AUF) is a rare, life-threatening condition wherein communication occurs between a ureter and the common, internal, or external iliac artery. The sensitivity of common clinical imaging examination for AUF is low, which leads to a delayed diagnosis and increased mortality. In addition, the increased use of ureteral stents contributes to the growing frequency of AUF. Read More

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Arterial to end-tidal CO gradients during isocapnic hyperventilation.

J Clin Monit Comput 2022 Jul 27. Epub 2022 Jul 27.

Department of Anesthesiology, OLV Hospital, Aalst, Belgium.

Isocapnic hyperventilation (ICHV) is occasionally used to maintain the end-expired CO partial pressure (PCO) when the inspired CO (PCO) rises. Whether maintaining PCO with ICHV during an increase of the PCO also maintains arterial PCO (PCO) remains poorly documented. 12 ASA PS I-II subjects undergoing a robot-assisted radical prostatectomy (RARP) (n = 11) or cystectomy (n = 1) under general endotracheal anesthesia with sevoflurane in O/air (40% inspired O) were enrolled. Read More

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A New Technique for Continent Urinary Diversion: Initial Experience and Description of the Technique.

Urol J 2022 Jul 17. Epub 2022 Jul 17.

Department of Urology, Ospedale del Mare, Naples, Italy.

Purpose: Orthotopic neobladder is a well-established surgical solution for continent urinary diversion after radical cystectomy. Nevertheless, it still represents a challenging surgery. Some critical issues of orthotopic bladder substitution include relevant complication rates, renal function impairment, urinary incontinence and patient quality of life. Read More

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Prediction of Response to Cisplatin-Based Neoadjuvant Chemotherapy of Muscle-Invasive Bladder Cancer Patients by Molecular Subtyping including KRT and FGFR Target Gene Assessment.

Int J Mol Sci 2022 Jul 18;23(14). Epub 2022 Jul 18.

STRATIFYER Molecular Pathology GmbH, 50935 Cologne, Germany.

Patients with muscle-invasive urothelial carcinoma achieving pathological complete response (pCR) upon neoadjuvant chemotherapy (NAC) have improved prognosis. Molecular subtypes of bladder cancer differ markedly regarding sensitivity to cisplatin-based chemotherapy and harbor FGFR treatment targets to various content. The objective of the present study was to evaluate whether preoperative assessment of molecular subtype as well as FGFR target gene expression is predictive for therapeutic outcome-rate of ypT0 status-to justify subsequent prospective validation within the "BladderBRIDGister". Read More

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Perioperative Complications and Oncologic Outcomes after Radical Cystectomy in End-Stage Renal Disease Patients with Bladder Cancer Obtained Using a Standardized Reporting System.

Cancers (Basel) 2022 Jul 19;14(14). Epub 2022 Jul 19.

Division of Urology, Department of Surgery, Chang Gung Memorial Hospital at Chiayi, Chiayi 613016, Taiwan.

Background: We investigated the use of a standardized reporting system to study perioperative complications and oncologic outcomes after radical cystectomy in end-stage renal disease (ESRD) patients with bladder cancer.

Methods: We reviewed retrospective outcomes in 141 ESRD patients with bladder cancer who underwent radical cystectomy between 2004 and 2015. Complications were graded using the Clavien-Dindo classification system with 0-2 classified as "No Major Complications" and Clavien 3-5 as "Major Complications". Read More

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The CUSUM curve combined with comprehensive complication index for assessing short-term complications of radical cystectomy.

J Clin Lab Anal 2022 Jul 26:e24616. Epub 2022 Jul 26.

Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin, China.

Objective: To evaluate the comprehensive complication index(CCI) and Clavien-Dindo classification(CDC) for short-term postoperative complications in radical cystectomy and assess cumulative surgical morbidity to compare sufficient surgical skill.

Methods: From September 30, 2010, to October 1, 2020, clinical data of patients with urothelial carcinoma who underwent radical cystectomy with urinary diversion were gathered, patients who had only a urinary diversion, bladder sparing surgery, additional abdominal surgeries at the same time were all excluded. The CDC and CCI were utilized to evaluate 30-d complications after radical cystectomy and the relevance of hospital stay was compared between CCI and CDC. Read More

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Bladder-sparing (chemo)radiotherapy in elderly patients with muscle-invasive bladder cancer: a retrospective cohort study.

Acta Oncol 2022 Jul 26:1-7. Epub 2022 Jul 26.

Department of Radiotherapy, Erasmus MC Cancer Institute, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Background: Organ-sparing treatment for muscle-invasive bladder cancer by maximal transurethral removal of the tumor (TURB) followed by chemoradiation (CRT) has shown promising results in recent studies, and is therefore considered to be an acceptable alternative for the standard of radical cystectomy (RC) in selected patients. We report on outcomes in a single-center, retrospective CRT cohort in comparison to a RC and radiotherapy only (RT) cohort.

Patients And Methods: The patient population included  = 84 CRT patients,  = 93 RC patients, and  = 95 RT patients. Read More

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A Phase I Trial of Neoadjuvant Stereotactic Body Radiotherapy Prior to Radical Prostatectomy for Locally Advanced Prostate Cancer.

Int J Radiat Oncol Biol Phys 2022 Jul 22. Epub 2022 Jul 22.

Department of Radiation Oncology, University of Michigan, Ann Arbor, MI, USA; Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Comprehensive Cancer Center, Cleveland, OH, USA. Electronic address:

PURPOSE Men with locally advanced prostate cancer who undergo radical prostatectomy (RP) often develop recurrence and require post-operative radiotherapy. We aimed to determine the safety of neoadjuvant stereotactic body radiotherapy (SBRT) prior to RP in this population. PATIENTS AND METHODS A single institution phase I trial (NCTXXXX) of men with high-risk or node positive prostate cancer enrolled between 3/2017-10/2017. Read More

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Opioid-free anesthesia for open radical cystectomy in morbid obesity.

Rev Esp Anestesiol Reanim (Engl Ed) 2022 Jul 19. Epub 2022 Jul 19.

Servicio de Anestesiología y Reanimación, Hospital Universitario Virgen de la Victoria, Málaga, Spain; Instituto de Investigación Biomédica de Málaga, Málaga, Spain; Departamento de Pediatría y Farmacología, Universidad de Málaga, Málaga, Spain.

Opioid-free anaesthesia shows evidence about its efectivity and security, even though its risks and benefits are not well defined. Neither are the patient profile or sort of surgery where it could be superior to the conventional opioid-based anaesthetic technique. Aggressive and/or long-lasting surgeries set out several queries on this technique regarding sudden hemodynamic changes, as it does not produce sympatholysis through μ receptor and there is modest experience in this technique. Read More

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