7,190 results match your criteria Cystectomy Radical


Machine learning models for predicting post-cystectomy recurrence and survival in bladder cancer patients.

PLoS One 2019 20;14(2):e0210976. Epub 2019 Feb 20.

Department of Aerospace and Mechanical Engineering, Viterbi School of Engineering, University of Southern California, University Park Campus, Los Angeles, CA, United States of America.

Currently in patients with bladder cancer, various clinical evaluations (imaging, operative findings at transurethral resection and radical cystectomy, pathology) are collectively used to determine disease status and prognosis, and recommend neoadjuvant, definitive and adjuvant treatments. We analyze the predictive power of these measurements in forecasting two key long-term outcomes following radical cystectomy, i.e. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210976PLOS
February 2019

Can Neutrophil-to-Lymphocyte ratio predict the response to BCG in high-risk non muscle invasive bladder cancer?

Int Braz J Urol 2018 Nov 3;45. Epub 2018 Nov 3.

Department of Urology, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS - Università Cattolica del Sacro Cuore di Roma.

Objectives: To evaluate the neutrophil-to-lymphocyte ratio (NLR) as a prognostic factor for response of high risk non muscle invasive bladder cancer (HRNMIBC) treated with BCG therapy.

Materials And Methods: Between March 2010 and February 2014 in a tertiary center 100 consecutive patients with newly diagnosed HRNMIBC were retrospectively analyzed. Patients were divided according to NLR value: 46 patients with NLR value less than 3 (NLR < 3 group), and 54 patients with NLR value more than 3 (NLR ≥ 3 group). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0249DOI Listing
November 2018

Efficacy of Prophylactic Antimicrobial Administration of Tazobactam/Piperacillin for Radical Cystectomy with Urinary Diversion: A Multicenter Study.

Urol Int 2019 Feb 18:1-6. Epub 2019 Feb 18.

Department of Urology, Kobe University Graduate School of Medicine, Kobe, Japan.

Objectives: The purpose of this study was to investigate the association between prophylactic antibiotic administration (PAA) and postoperative infection after radical cystectomy with urinary diversion in patients with invasive bladder cancer.

Methods: Forty-nine consecutive cases were analyzed prospectively. Postoperative infections were categorized as surgical site infection (SSI) and remote infection (RI). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496209DOI Listing
February 2019

Molecular Predictors of Complete Response Following Neoadjuvant Chemotherapy in Urothelial Carcinoma of the Bladder and Upper Tracts.

Int J Mol Sci 2019 Feb 13;20(4). Epub 2019 Feb 13.

Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

Urothelial carcinoma of the bladder (UCB) and upper tracts (UTUC) is often regarded as one entity and is managed generally with similar principles. While neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) is an established standard of care in UCB, strong evidence for a similar approach is lacking in UTUC. The longest survival is seen in patients with complete response (pT0) on pathological examination of the RC specimen, but impact of delayed RC in nonresponders may be detrimental. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/ijms20040793DOI Listing
February 2019

Prospective implementation of a nonopioid protocol for patients undergoing robot-assisted radical cystectomy with extracorporeal urinary diversion.

Urol Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Urology, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address:

Objectives: To evaluate the feasibility and outcomes of a nonopioid (NOP) perioperative pain management protocol for patients undergoing robot-assisted radical cystectomy (RARC).

Materials And Methods: We prospectively included 52 consecutive patients undergoing RARC at our institution for bladder cancer. Patients received a multimodal pain management protocol, including a combination of nonopioid pain medications and regional anesthesia. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2019.02.002DOI Listing
February 2019

Defining a "High Volume" Radical Cystectomy Hospital: Where Do We Draw the Line?

Eur Urol Focus 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, Vattikuti Urology Institute, Henry Ford Hospital, Detroit, MI, USA.

Background: Centralization of radical cystectomy (RC) to "high volume" centers can lead to decreased morbidity but also limits access to care. In the context of centralization, there is a need to systematically define the hospital volume cutoffs for this procedure.

Objective: To systematically examine the effect of hospital volume on inpatient complications of RC for bladder cancer and to define a threshold to minimize RC morbidity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euf.2019.02.001DOI Listing
February 2019

Contemporary trends of pelvic lymph node dissection at radical cystectomy for urothelial carcinoma of urinary bladder and associated cancer specific mortality and complications: comparison between octogenarian versus younger patients.

Cancer Epidemiol 2019 Feb 13;59:135-142. Epub 2019 Feb 13.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Québec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: We analysed contemporary pelvic lymph node dissection (PLND) trend during radical cystectomy (RC) for urothelial carcinoma of urinary bladder (UCUB), as well as PLND association with cancer specific mortality (CSM) and complications after stratification according to octogenarian vs. younger age.

Materials And Methods: Within the SEER and NIS databases, respectively 10,427 (T2 and T3 stages) and 19,203 (all T-stages) RC patients (2004-2015) for UCUB were identified. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.canep.2019.02.002DOI Listing
February 2019
1 Read

Oncologic and reproductive outcomes of cystectomy as a fertility-sparing treatment for early-stage epithelial ovarian cancer.

Int J Clin Oncol 2019 Feb 15. Epub 2019 Feb 15.

Department of Obstetrics and Gynecology, Graduate School of Medicine, Nagoya University, Truma-cho 65, Showa-ku, 466-8550, Nagoya, Japan.

Background: Fertility-sparing surgery (FSS) has mainly been chosen for young women with ovarian-confined/well-differentiated epithelial ovarian cancer (EOC). In general, FSS consists of at least conservation of contralateral ovary and the uterus with a staging surgery. However, information on the clinical outcome in women who underwent cystectomy as a fertility-preserving option is lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10147-019-01416-yDOI Listing
February 2019

Trans-Fascial Placement of a High, Sub Muscular Reservoir in Patients Following Radical Cystectomy: Safety, Efficacy, and Predictability of Final Reservoir Location Verified With Abdominal Imaging.

J Sex Med 2019 Feb;16(2):338-345

Department of Urology, University of Miami Miller School of Medicine, Miami, FL, USA.

Introduction: With the increasing utilization of ectopic reservoir placement during multicomponent penile implant surgery, safety concerns have been raised about whether passing the reservoir through the floor of the inguinal canal consistently results in placement of the reservoir within the correct location.

Aim: To evaluate the safety, efficacy, and patient satisfaction associated with direct-vision, trans-fascial sub muscular reservoir placement in consecutive patients who had previously undergone radical cystectomy.

Methods: Perioperative data, complications, and follow up for the 12 cystectomy patients were evaluated using a comprehensive database of consecutive patients undergoing penile prosthesis placement at our center. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jsxm.2018.12.015DOI Listing
February 2019
1 Read

Upper urinary tract recurrence following bladder cancer therapy: a review of surveillance and management.

Curr Opin Urol 2019 Feb 11. Epub 2019 Feb 11.

USC Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, USA.

Purpose Of Review: Our aim is to review recent investigations into the recurrence of urothelial carcinoma in the upper urinary tract following bladder cancer therapy focusing on surveillance and management.

Recent Findings: After radical cystectomy, rates of recurrence in the upper tract are between 0.75 and 6. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOU.0000000000000598DOI Listing
February 2019
1 Read

Salvage therapeutic strategies for bacillus Calmette-Guerin failure.

Curr Opin Urol 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology and Comprehensive Cancer Center, Vienna General Hospital, Medical University of Vienna.

Purpose Of Review: To give an overview of current options for conservative treatment of patients failing intravesical bacillus Calmette-Guerin (BCG) and to discuss emerging approaches with potential future clinical applications.

Recent Findings: Radical cystectomy is the standard-of-care for patients failing BCG therapy. In patients unfit or unwilling to undergo surgery, salvage therapy options could be proposed with the aim to offer local cancer control and prevent progression to muscle-invasive disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MOU.0000000000000593DOI Listing
February 2019
8 Reads

[Intraoperative complications of radical cystectomy with various types of urinary diver- sions].

Urologiia 2018 Oct(4):102-105

National Oncology Center, Azerbaijan, Baku.

Aim: To investigate the rates, types and risk factors for intraoperative complications in patients with bladder cancer undergoing radical cystectomy with various types of urinary diversions.

Material And Methods: The study comprised 257 patients, including 241 (93.8%) men and 16 (6. Read More

View Article

Download full-text PDF

Source
October 2018
1 Read

Multiple cutaneous metastasis of synchronous urothelial carcinoma of the bladder and the renal pelvis: a case report.

J Med Case Rep 2019 Feb 14;13(1):34. Epub 2019 Feb 14.

Surgical Oncology Department, Institute Salah Azaiez de Cancer, Tunis, Tunisia.

Introduction: Cutaneous metastatic disease arising from urinary tract carcinoma is rare and associated with a poor prognosis. We report a case of metastatic disease occurring in a patient treated for synchronous urothelial tumor of the bladder and left renal pelvis.

Case Presentation: A 61-year-old Caucasian man was treated for a synchronous urothelial tumor of the bladder and left renal pelvis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13256-019-1997-8DOI Listing
February 2019
1 Read

Palliative Care Use Among Patients with Bladder Cancer.

BJU Int 2019 Feb 13. Epub 2019 Feb 13.

Department of Urology, University of Pittsburgh School of Medicine, Pittsburgh, PA.

Objectives: To describe the rate and determinants of palliative care use among Medicare beneficiaries with bladder cancer and encourage a national dialogue on improving coordinated urologic, oncologic, and palliative care in patients with genitourinary malignancies.

Materials And Methods: Using Surveillance, Epidemiology, and End Results-Medicare data, we identified patients diagnosed with muscle-invasive bladder cancer between 2008-2013. Our primary outcome was receipt of palliative care, defined as the presence of a claim submitted by a Hospice and Palliative Medicine subspecialist. Read More

View Article

Download full-text PDF

Source
http://doi.wiley.com/10.1111/bju.14708
Publisher Site
http://dx.doi.org/10.1111/bju.14708DOI Listing
February 2019
5 Reads

Contemporary use and survival after perioperative systemic chemotherapy in patients with locally advanced non-metastatic urothelial carcinoma of the bladder treated with radical cystectomy.

Eur J Surg Oncol 2019 Feb 3. Epub 2019 Feb 3.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada.

Background: Locally advanced muscle-invasive bladder cancer (MIBC) patients who are candidates for radical cystectomy (RC) should receive perioperative chemotherapy (CHT). However, the adherence to CHT guidelines is low. Thus, we tested contemporary CHT use rates and associated cancer-specific mortality (CSM) and overall mortality (OM) rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ejso.2019.01.218DOI Listing
February 2019

Histologic variants associated with biological aggressiveness and poor prognosis in patients treated with radical cystectomy.

Jpn J Clin Oncol 2019 Feb 8. Epub 2019 Feb 8.

Department of Urology, Kitasato University School of Medicine, Kanagawa 252-0374, Japan.

Background: The prognostic value of histologic variants (HV) after radical cystectomy (RC) remains controversial. We evaluated the clinicopathological features and prognosis in patients with pure urothelial carcinoma (UC) and HV following RC.

Methods: From 1990 to 2015, 286 patients with bladder cancer were treated with RC at six Kitasato University-affiliated hospitals. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jjco/hyz015DOI Listing
February 2019

Treatment Approaches for Cisplatin-Ineligible Patients with Invasive Bladder Cancer.

Curr Treat Options Oncol 2019 Feb 11;20(2):12. Epub 2019 Feb 11.

Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, 450 Brookline Ave, DANA 1230, Boston, MA, 02215, USA.

Opinion Statement: Cisplatin has been established as an important agent in the neoadjuvant setting prior to radical cystectomy (RC) surgery for muscle-invasive urothelial cancer (MIUC) as well as in the unresectable or metastatic urothelial carcinoma (mUC) setting. Unfortunately, many patients in practice are felt to be "cisplatin-ineligible." Thus, it is vital that we develop treatment approaches and novel therapeutics for this population. Read More

View Article

Download full-text PDF

Source
http://link.springer.com/10.1007/s11864-019-0609-6
Publisher Site
http://dx.doi.org/10.1007/s11864-019-0609-6DOI Listing
February 2019
9 Reads

The impact of non-urothelial variant histology on oncological outcomes following radical cystectomy.

BJU Int 2019 Feb 11. Epub 2019 Feb 11.

Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.

Objectives: To determine if the presence of non-urothelial variant histology (NUVH) is associated with a poorer prognosis following radical cystectomy compared to pure urothelial carcinoma.

Patients And Methods: A prospectively maintained database of all patients undergoing radical cystectomy (RC) at a high-volume regional tertiary bladder cancer service between January 2010 and January 2017 was retrospectively analysed looking for patients displaying NUVH. Multivariate Cox proportional hazards regression analysis was used to determine disease recurrence, overall and bladder cancer specific survival as well as lymph node positivity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bju.14704DOI Listing
February 2019

Single-Port Trans-Perineal Approach to Cystoprostatectomy with Intracorporeal Ileal Conduit Urinary Diversion and Lymph-Nodes Dissection using a Purpose-Built Robotic System: Surgical Steps in a Preclinical Model.

Int Braz J Urol 2018 Nov 17;44. Epub 2018 Nov 17.

Glickman Urological & Kidney Institute, Cleveland Clinic, Cleveland OH, USA.

Aim: To report the technique for single-port trans-perineal cystoprostatectomy with intracorporeal ileal conduit urinary diversion and lymph nodes dissection using a purpose-built robotic platform (da Vinci SP1098, Intuitive Surgical, Sunny¬vale, CA, USA).

Materials And Methods: In a male cadaver the SP1098 robotic system was used to perform cystoprostatectomy with intracorporeal ileal conduit urinary diversion and lymph nodes dissection by single-port trans-perineal approach. The surgery was completed through a 2. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1677-5538.IBJU.2018.0524DOI Listing
November 2018

Early Mortality in Patients With Muscle-Invasive Bladder Cancer Undergoing Cystectomy in the United States.

JNCI Cancer Spectr 2018 Nov 28;2(4):pky075. Epub 2019 Jan 28.

Background: Although radical cystectomy (RC) is a standard treatment for muscle-invasive bladder cancer (MIBC), for many patients the risks versus benefits of RC may favor other approaches. We sought to define the landscape of early postcystectomy mortality in the United States and identify patients at high risk using pretreatment variables.

Methods: We identified patients with MIBC (cT2-T4aN0M0) who underwent RC without perioperative chemotherapy within the National Cancer Database (2003-2012). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1093/jncics/pky075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6349610PMC
November 2018

Accurate Quantification of Residual Cancer Cells in Pelvic Washing Reveals Association with Cancer Recurrence Following Robot-Assisted Radical Cystectomy.

J Urol 2019 Feb 5. Epub 2019 Feb 5.

Department of Urology, Roswell Park Comprehensive Cancer Center, Buffalo, NY.

Background: Bladder cancer recurrence following cystectomy remains a significant cause of bladder cancer-specific mortality. Residual cancer cells (RCCs) contribute to cancer recurrence due either to tumor spillage or undetectable pre-existing micrometastatic tumor clones. We sought to detect and quantify RCCs in pelvic washing using ultra-deep targeted sequencing (UTS) and compare the levels of RCCs with clinical variables and cancer recurrence. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JU.0000000000000142DOI Listing
February 2019
1 Read
4.471 Impact Factor

Contemporary best practice in the use of neoadjuvant chemotherapy in muscle-invasive bladder cancer.

Ther Adv Urol 2019 Jan-Dec;11:1756287218823678. Epub 2019 Jan 28.

Department of Urology, Paris Descartes University, Paris, France.

Background: We aimed to provide a comprehensive literature review on the best practice management of patients with nonmetastatic muscle-invasive bladder cancer (MIBC) using neoadjuvant chemotherapy (NAC).

Method: Between July and September 2018, we conducted a systematic review using MEDLINE and EMBASE electronic bibliographic databases. The search strategy included the following terms: Neoadjuvant Therapy and Urinary Bladder Neoplasms. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1756287218823678DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6350113PMC
January 2019
1 Read

The impact of minimal invasive surgery on early complications and mortality after radical cystectomy for muscle-invasive urothelial bladder cancer.

J BUON 2018 Dec;23(7):104-110

Department of Urology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.

Purpose: to evaluate the 30-day death rate and the factors associated with short-term complications after radical cystectomy for muscle-invasive urothelial bladder cancer.

Methods: The study included 123 patients (age 64.1±7. Read More

View Article

Download full-text PDF

Source
December 2018

Sulfasalazine may modulate the CD44v9-xCT system and enhance CDDP-induced cytotoxic effects in metastatic bladder cancer.

Cancer Sci 2019 Feb 4. Epub 2019 Feb 4.

Department of Urology, Keio University School of Medicine, Tokyo, Japan.

The prognostic role of CD44v9, a variant isoform of CD44 and a new cell surface marker of cancer stem cells, remains unclear in bladder cancer (BC) patients. Furthermore, limited information is available on the functional role of sulfasalazine (SSZ), which may modulate the CD44v9-xCT system in order to enhance CDDP-induced cytotoxicity and inhibit the metastatic potential of BC. CD44v9 protein expression was examined immunohistochemically in 63 muscle invasive BC (MIBC) patients who underwent radical cystectomy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/cas.13960DOI Listing
February 2019

Induction Chemotherapy Followed by Surgery Versus Upfront Radical Cystectomy in Patients With Clinically Node-positive Muscle-invasive Bladder Cancer.

Clin Genitourin Cancer 2019 Jan 9. Epub 2019 Jan 9.

Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. Electronic address:

Background: The aim of this study was to compare survival outcomes in patients with clinically node-positive muscle-invasive bladder cancer receiving induction chemotherapy (IC) followed by surgery and those who underwent upfront radical cystectomy (RC).

Patients And Methods: Outcomes were reviewed in patients with cT2-4N1-3M0 bladder cancer treated with IC followed by surgery or upfront RC between January 1995 and June 2017. Survival outcomes were analyzed using a propensity score matched cohort analysis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.clgc.2019.01.001DOI Listing
January 2019
1 Read

Impact of Immune and Stromal Infiltration on Outcomes Following Bladder-sparing Trimodality Therapy for Muscle-invasive Bladder Cancer.

Eur Urol 2019 Jan 31. Epub 2019 Jan 31.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Massachusetts General Hospital Cancer Center, Boston, MA, USA.

Background: Bladder-sparing trimodality therapy (TMT) is an alternative to radical cystectomy (RC) for muscle-invasive bladder cancer (MIBC), and biomarkers to inform therapy selection are needed.

Objective: To evaluate the prognostic value of immune and stromal signatures in MIBC treated with TMT.

Design, Setting, And Participants: We used a clinical-grade platform to perform transcriptome-wide gene expression profiling of primary tumors from 136 MIBC patients treated with TMT at a single institution. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2019.01.011DOI Listing
January 2019
1 Read

Massage and reflexology for post-operative cancer cystectomy patients: Evaluation of a pilot service.

Complement Ther Clin Pract 2019 Feb 14;34:109-112. Epub 2018 Nov 14.

St Luke's Cancer Centre, Royal Surrey County Hospital, Guildford, England, GU2 7XX, United Kingdom.

Background: and purpose: Radical cystectomy is a gold standard treatment for invasive bladder cancer. However the length of the operation is long and recovery is usually slow and painful. There is growing recognition of the importance of health related quality of life among patients undergoing invasive surgical procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.ctcp.2018.11.010DOI Listing
February 2019

Survival and metastasis in muscle-invasive bladder cancer patients who present with indeterminate pulmonary nodules before treatment.

Ann Saudi Med 2019 Jan-Feb;39(1):42-47

Dr. Ali Al-daghmin, Department of Surgery, King Hussein Cancer Center, 1269 Al-Jubeiha, Amman, Jordan, T: +962796230136, jo, ORCID: http://orcid.org/0000-0001-8716-6713.

Background: Indeterminate pulmonary nodules (IPNs) are common during initial evaluation of bladder cancer patients. Their significance is still unknown.

Objective: Determine the significance of indeterminate pulmonary nodules, including their size and number, in muscle-invasive bladder cancer patients before definitive local therapy by surgery or chemo-radiotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5144/0256-4947.2019.42DOI Listing
February 2019
3 Reads
0.705 Impact Factor

Wide Variation in Opioid Prescribing After Urological Surgery in Tertiary Care Centers.

Mayo Clin Proc 2019 Feb;94(2):262-274

Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: To describe postoperative opioid prescribing practices in a large cohort of patients undergoing urological surgery.

Patients And Methods: We identified 11,829 patients who underwent 21 urological surgical procedures at 3 associated facilities from January 1, 2015, through December 31, 2016. After converting opioids to oral morphine equivalents (OMEs), prescribing patterns were compared within and across procedures. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mayocp.2018.08.035DOI Listing
February 2019
1 Read

Detection of pagetoid urothelial intraepithelial neoplasia extending to the vagina by cervical screening cytology: a case report with renewed immunochemical summary.

Diagn Pathol 2019 Feb 2;14(1). Epub 2019 Feb 2.

Department of Diagnostic Pathology and Cytology, Osaka International Cancer Institute Hospital, 3-1-69 Otemae, Chuo-ku, Osaka, 541-8567, Japan.

Background: Pagetoid spread of urothelial carcinoma (UC) to the lower genital tract is quite a rare and diagnostically challenging condition. Pagetoid urothelial intraepithelial neoplasia extending to the vagina is difficult to diagnose, especially in remote recurrences without symptomatic or macroscopic lesions typical to Paget disease. However, its identification by cervical screening cytology is important because UC is often characterized by a long history of relapse. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1186/s13000-019-0788-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6359825PMC
February 2019
3 Reads

Complications and reoperations after laparoscopic radical cystectomy in a Japanese multicenter cohort.

Int J Urol 2019 Feb 1. Epub 2019 Feb 1.

Department of Urology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Objectives: To describe the complications and their surgical management after laparoscopic radical cystectomy in a Japanese multicenter cohort.

Methods: The participants were drawn from a retrospective multicenter study at 10 institutions. We identified 436 patients who underwent laparoscopic radical cystectomy with no robot assistance. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/iju.13917DOI Listing
February 2019
2 Reads

Perioperative Outcomes and Complications after Robotic Radical Cystectomy with Intra-Corporeal or Extra-Corporeal Ileal Conduit Urinary Diversion: Head-to-head Comparison from a Single-Institutional Prospective Study.

Urology 2019 Jan 29. Epub 2019 Jan 29.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA. Electronic address:

Objective: to compare perioperative and oncological outcomes of intracorporeal (ICUD) vs extracorporeal urinary diversion ECUD after robot-assisted radical cystectomy (RARC).

Methods: From January 2014 to December 2017, data of consecutive patients who underwent RARC performed by 2 institutional surgeons were prospectively collected in a dedicated database (IRB: 251647). Patients were divided in 2 groups according to the operating surgeon, one performing ECUD, the other ICUD. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2018.11.059DOI Listing
January 2019

Squamous cell carcinoma of the bladder: poor response to neoadjuvant chemotherapy.

Int J Clin Oncol 2019 Feb 1. Epub 2019 Feb 1.

Division of Urology, Department of Surgery, Saint Louis University, 3635 Vista Ave, 3rd Floor Desloge Towers, St. Louis, MO, 63110, USA.

Background: Squamous cell carcinoma (SCC) of the bladder is a rare, aggressive malignancy. Unlike urothelial cell carcinoma, SCC is resistant to chemotherapy and guidelines recommend radical cystectomy (RC) without neoadjuvant chemotherapy (NAC). We aimed to evaluate the current management and survival of patients with invasive SCC treated with or without NAC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s10147-019-01409-xDOI Listing
February 2019
1 Read

Long term oncologic outcome in patients with bladder cancer after radical cystectomy: Impact of carcinoma in situ in the era of neoadjuvant chemotherapy.

Int Urol Nephrol 2019 Jan 31. Epub 2019 Jan 31.

Institute of Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Purpose: To assess the impact of carcinoma in situ (CIS) on oncologic outcomes in patients who underwent radical cystectomy, with a focus on those who received neoadjuvant chemotherapy (NAC) including patients with down-staging to ≤ pT1cancer after chemotherapy.

Materials And Methods: All patients who underwent radical cystectomy for urothelial cancer with curative intent from 1985 to 2011 were included. The impact of CIS on recurrence free and overall survival (OS) was assessed in the whole cohort and a subgroup who received NAC as well as those with response to chemotherapy and down-staging to ≤ pT1. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11255-019-02087-4DOI Listing
January 2019
1.293 Impact Factor

The impact of squamous histology on survival in patients with muscle-invasive bladder cancer.

Urol Oncol 2019 Jan 28. Epub 2019 Jan 28.

Department of Urology, Columbia University Medical Center, New York, NY.

Background: Bladder cancer is the ninth most common noncutaneous malignancy worldwide, though a fraction (2%-5%) are diagnosed as squamous cell carcinoma (SCC) in the Western world. Current understanding is based on small, single-institution studies and SEER-database reviews with conflicting results. We used the National Cancer Database to explore clinical characteristics and outcomes from a large cohort of invasive bladder SCC. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2019.01.020DOI Listing
January 2019
5 Reads

Health-related quality of life after radical cystectomy and ileal orthotopic neobladder: effect of detailed continence outcomes.

World J Urol 2019 Jan 30. Epub 2019 Jan 30.

Department of Urology, Ludwig-Maximilians-University, Marchioninistrasse 15, 81377, Munich, Germany.

Purpose: To objectively quantify continence rates and to correlate continence outcomes with health-related quality of life (HRQOL) after radical cystectomy and orthotopic ileal neobladder (ONB).

Methods: Questionnaires were sent to 244 patients who underwent radical cystectomy with ONB between 2004 and 2015, and information about the current continence status was retrieved. To objectify postoperative urine loss, daytime and nocturnal pad tests were performed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-019-02643-8DOI Listing
January 2019
1 Read

In-Hospital Outcomes after Radical Cystectomy for Bladder Cancer: Comparing National Trends in the United States and Germany from 2006 to 2014.

Urol Int 2019 Jan 30:1-9. Epub 2019 Jan 30.

Department of Urology, Medical Faculty Carl Gustav Carus, TU Dresden, Dresden, Germany.

Background: Radical cystectomy (RC) still poses a significant risk for mortality and morbidity.

Objectives: We compared in-hospital outcomes after RC in the United States and -Germany using population-based data.

Methods: We compared data from the US Nationwide Inpatient Sample to the German hospital billing database. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000496347DOI Listing
January 2019

Radical Cystectomy in Pathological T4a and T4b Bladder Cancer Patients: Is There Any Space for Sub Stratification?

Urol Int 2019 Jan 29:1-8. Epub 2019 Jan 29.

Division of Oncology, Unit of Urology, IRCCS Ospedale San Raffaele, Milan, Italy.

Introduction: According to TNM staging, pathological T4ab are comprehensive of the invasion of prostate, seminal vesicles, uterus or vagina and pelvic or abdominal wall. However, few data are available on the perioperative and oncological outcomes of specific organ invasion.

Materials And Methods: A total of 917 consecutive bladder cancer (BCa) patients treated with radical cystectomy (RC) at a single institution between 1990 and 2015 were studies. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000493899DOI Listing
January 2019
1 Read

The Feasibility of a Healthcare Application in the Management of Patients Undergoing a Radical Cystectomy.

J Urol 2019 Jan 25. Epub 2019 Jan 25.

University of Kansas Health System, Department of Urology.

Purpose: Patients who undergo radical cystectomy for bladder cancer are at high risk of complications and readmissions. Studies indicate insufficient preoperative education and perioperative monitoring. The aim of this study is to demonstrate the feasibility of implementing a health care application to provide more patient education and more thorough monitoring perioperatively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/JU.0000000000000050DOI Listing
January 2019
3 Reads

Utility of robot-assisted radical cystectomy with intracorporeal urinary diversion for muscle-invasive bladder cancer.

Int J Urol 2019 Jan 28. Epub 2019 Jan 28.

Department of Urology, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan.

Radical cystectomy remains the gold standard for treatment of muscle-invasive bladder. Robot-assisted radical cystectomy has technical advantages over laparoscopic radical cystectomy and has emerged as an alternative to open radical cystectomy. Despite the advancements in robotic surgery, experience with total intracorporeal reconstruction of urinary diversion remains limited. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/iju.13900DOI Listing
January 2019

Editorial Comment to Utility of robot-assisted radical cystectomy with intracorporeal urinary diversion for muscle-invasive bladder cancer.

Int J Urol 2019 Jan 28. Epub 2019 Jan 28.

Department of Urology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/iju.13906DOI Listing
January 2019

Penile Implant Considerations in the Bladder Cancer Survivor.

Curr Urol Rep 2019 Jan 28;20(2). Epub 2019 Jan 28.

Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Suite 7416, Los Angeles, CA, 90089-9178, USA.

Purpose Of Review: After radical cystoprostatectomy, patients often develop erectile dysfunction refractory to first- and second-line treatments. In this review, we summarize and analyze the literature describing the technical considerations and outcomes of penile implant surgery in bladder cancer patients with history of radical cystectomy and urinary diversion.

Recent Findings: Penile prosthesis surgery in patients after radical cystectomy and urinary diversion has been infrequently described in the literature. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11934-019-0873-9DOI Listing
January 2019
1 Read

Frailty and sarcopenia impact surgical and oncologic outcomes after radical cystectomy in patients with bladder cancer.

Transl Androl Urol 2018 Dec;7(Suppl 6):S763-S764

Department of Urology, Wake Forest University School of Medicine, Wake Forest University, Health Sciences Medical Center, Boulevard, Winston-Salem, NC, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/tau.2018.08.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323269PMC
December 2018

Impact of immunonutrition on radical cystectomy immunoresponse and outcomes; opportunity for peri-operative optimization.

Transl Androl Urol 2018 Dec;7(Suppl 6):S760-S762

Division of Urologic Oncology, Department of Urology, NYU Langone Health, New York, NY, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/tau.2018.08.09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323266PMC
December 2018

The timing of radical cystectomy following neoadjuvant chemotherapy.

Transl Androl Urol 2018 Dec;7(Suppl 6):S758-S759

Division of Urology, Department of Surgery, Brigham and Women's Hospital, Boston, MA, USA.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.21037/tau.2018.08.07DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6323272PMC
December 2018
1 Read