8,016 results match your criteria Cystectomy Radical


The Cancer of the Bladder Risk Assessment (COBRA) score for Estimating Cancer-Specific Survival after Radical Cystectomy: External Validation in a Large Bi-institutional Cohort.

BJU Int 2020 Jul 8. Epub 2020 Jul 8.

Department of Urology, University Hospitals Leuven, Leuven, Belgium.

Objective: To perform an external validation of the Cancer of the Bladder Risk Assessment (COBRA) score for estimating cancer-specific survival (CSS) after radical cystectomy (RC) in a large bi-institutional cohort of patients.

Patients And Methods: Patients treated with RC and lymph node dissection (LND) between May 1996 and July 2017 were retrieved from the RC databases of Leuven and Turin. Collected variables were age at RC, tumor stage, lymph node (LN) density, neoadjuvant chemotherapy, the extent of LND, and nodal stage. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bju.15163DOI Listing

[Plasmacytoid variant of urothelial bladder cancer. A single center experience.]

Arch Esp Urol 2020 Jul;73(6):564-567

Urology Department. General Hospital of Athens "G.N.A. G. Gennimatas". Athens. Greece.

Introduction: Bladder Cancer (BC) is11th most common malignancy. In terms of pathology, the vast majority of patients suffer from transitional cell carcinoma. Apart from this common type of BC, there are many morphological subtypes with different oncological characteristics. Read More

View Article

Download full-text PDF

Source

Benefits of robotic cystectomy compared with open cystectomy in an Enhanced Recovery After Surgery program: A propensity-matched analysis.

Int J Urol 2020 Jul 7. Epub 2020 Jul 7.

Department of Urology, Sengkang General Hospital, Singapore.

Objectives: To compare the perioperative and oncological outcomes between robot-assisted radical cystectomy with intracorporeal urinary diversion versus open cystectomy for bladder cancer in a contemporary Enhanced Recovery After Surgery cohort.

Methods: All consecutive patients who underwent radical cystectomy and managed under an Enhanced Recovery After Surgery protocol, from December 2013 to October 2018, were reviewed. Propensity score adjustment was carried out to reduce biases attributable to covariate imbalances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/iju.14300DOI Listing

Bladder cancer in patients with spina bifida: a serious risk.

World J Urol 2020 Jul 6. Epub 2020 Jul 6.

Department of Pediatric, Adolescent and Reconstructive Urology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany.

Purpose: After bladder augmentation (BA) using bowel segments, it is known that there is a risk for secondary malignancies. It remains unclear whether this also applies to spina bifida (SB) patients without BA. The aim of this study was to analyze the frequency of bladder cancer (BC) in SB at a single tertiary institution and assess the patients' oncologic outcome. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-020-03338-1DOI Listing

Development and Cross-Validation of a Nomogram for Chronic Kidney Disease Following Robot-Assisted Radical Cystectomy.

J Endourol 2020 Jul 6. Epub 2020 Jul 6.

Roswell Park Cancer Insitute, Urologic Oncology, Elm and Carlton Streets, Buffalo, New York, United States, 14263.

Introduction: We sought to identify the factors associated with deterioration of renal functions after robot-assisted radical cystectomy (RARC), and to develop a nomogram to detect the probability of progression to chronic kidney disease (CKD).

Methods: A retrospective review of our prospectively maintained database. eGFR was calculated using the CKD-EPI creatinine formula utilizing all follow-up creatinine values. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/end.2020.0451DOI Listing

Enhanced recovery after surgery (ERAS) protocols in patients undergoing radical cystectomy with ileal urinary diversions: A randomized controlled trial.

Medicine (Baltimore) 2020 Jul;99(27):e20902

Fundeni Clinical Institute, Center of Uronephrology and Renal Transplant.

Background: Enhanced Recovery After Surgery (ERAS) protocols were introduced in clinical practice to reduce complication rates and hospital stay. We performed a randomized controlled single center study to evaluate perioperative benefits of an adapted ERAS protocol in patients with bladder cancer who underwent radical cystectomy (RC) and ileal urinary diversions (IUD).

Materials And Methods: Forty five from 90 consecutive randomized patients were enrolled in an adapted ERAS protocol. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/MD.0000000000020902DOI Listing

Rethinking the one-size-fits-most approach to venous thromboembolism prophylaxis after radical cystectomy.

Urol Oncol 2020 Jul 2. Epub 2020 Jul 2.

University of Michigan, Department of Urology, Ann Arbor, MI.

Objectives: Empirically dosed enoxaparin is routinely given in the postoperative period for venous thromboembolism (VTE) prophylaxis after radical cystectomy (RC). Patient-specific factors may alter its pharmacokinetics, and it is unclear whether this leads to levels sufficient for antithrombosis. We sought to evaluate variability of anti-factor Xa levels in a cohort of RC patients receiving perioperative enoxaparin prophylaxis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2020.05.007DOI Listing

Prognostic significance of serum lactate dehydrogenase in patients undergoing radical cystectomy for bladder cancer.

Urol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Urology, The No.1 Hospital of Shijiazhuang/Shijiazhuang People's Hospital, Shijiazhuang, China.

Background: To investigate the prognostic significance of preoperative serum lactate dehydrogenase (LDH) in patients undergoing radical cystectomy for bladder cancer (BCa).

Patients And Methods: A cohort of 263 patients undergoing open or laparoscopic radical cystectomy between 2011 and 2016 was studied. Baseline characteristics, hematological variables, follow-up data were collected. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2020.05.031DOI Listing

Long-term outcomes of incidental prostate cancer at radical cystectomy.

Urol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Urology, Mayo Clinic, Rochester, MN. Electronic address:

Objective: We evaluated the natural history and long-term outcomes of incidentally detected prostate cancer (PCa) at radical cystectomy (RC) for bladder cancer (BCa).

Patients And Methods: We identified 1,640 male patients who underwent RC between 1992 and 2012. Patients were stratified as clinically insignificant and clinically significant PCa, based on Grade Group (GG) 1 and ≥2, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2020.05.018DOI Listing

Reporting Radical Cystectomy Outcomes Following Implementation of Enhanced Recovery After Surgery Protocols: A Systematic Review and Individual Patient Data Meta-analysis.

Eur Urol 2020 Jul 2. Epub 2020 Jul 2.

USC Institute of Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA. Electronic address:

Context: Enhanced Recovery After Surgery (ERAS) is a perioperative approach to managing surgical patients. The impact of ERAS on radical cystectomy (RC) outcomes remains understudied.

Objective: To review the literature regarding ERAS protocols and RC outcomes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.eururo.2020.06.039DOI Listing

Global change of surgical and oncological clinical practice in urology during early COVID-19 pandemic.

World J Urol 2020 Jul 4. Epub 2020 Jul 4.

Department of Urology, University Medical Center, Johannes Gutenberg University, Langenbeckstr. 1, 55131, Mainz, Germany.

Objectives: While the coronavirus disease 2019 (COVID-19) pandemic captures healthcare resources worldwide, data on the impact of prioritization strategies in urology during pandemic are absent. We aimed to quantitatively assess the global change in surgical and oncological clinical practice in the early COVID-19 pandemic.

Methods: In this cross-sectional observational study, we designed a 12-item online survey on the global effects of the COVID-19 pandemic on clinical practice in urology. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s00345-020-03333-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335229PMC

The cost of obesity in radical cystectomy.

Urol Oncol 2020 Jun 30. Epub 2020 Jun 30.

Division of Urologic Surgery, Brigham and Women's Hospital, Boston, MA; Center for Surgery and Public Health, Brigham and Women's Hospital, Boston, MA; Dana-Farber Cancer Institute, Boston, MA; Harvard Medical School, Boston, MA. Electronic address:

Introduction: The prevalence of obesity is on the rise in the Unites States, and obesity has been associated with increased complications and costs in a variety of complex surgeries. However, the contribution of obesity to the overall costs of radical cystectomy has not been studied in detail using contemporary data. Our objective is to assess the variation in healthcare costs due to obesity on the index hospitalization for radical cystectomy in the United States between 2003 and 2015. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2020.05.014DOI Listing

Near-infrared fluorescence imaging of ureters with intravenous indocyanine green during radical cystectomy to prevent ureteroenteric anastomotic strictures.

Urology 2020 Jun 30. Epub 2020 Jun 30.

Department of Urology, Loyola University Medical Center, Maywood IL. Electronic address:

Objective: To determine whether intraoperative near-infrared fluorescence imaging (NFI) of the distal ureter using intravenous indocyanine green (ICG) could provide assessment of vascular adequacy and potentially decrease the risk of ureteroenteric anastomotic stricture (UAS).

Methods: A retrospective chart review was performed of all patients undergoing open radical cystectomy by a single surgeon over a 2-year period. Patients were divided into ICG and non-ICG cohorts based on utilization of ICG. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urology.2020.06.026DOI Listing

Exploring Urological Experience in the COVID-19 Outbreak: American Confederation of Urology (CAU) Survey.

Int Braz J Urol 2020 Jun 10;46. Epub 2020 Jun 10.

Department of Urology, Rochester General Hospital, Rochester New York, US.

Purpose: To explore the current situation faced by Latin American urology departments during the COVID-19 Outbreak in terms of knowledge, actions, prioritization of urology practices, and implementation of internal clinical management protocols for inpatients and outpatients.

Material And Methods: A non-validated, structured, self-administered, electronic survey with 35 closed multiple choice questions was conducted in Spanish, Portuguese, Italian, and English and Deutsch versions from April 1st to April 30th, 2020. The survey was distributed through social networks and the official American Confederation of Urology (CAU) website. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1677-5538.IBJU.2020.S119DOI Listing

Epigenetic profiling demarcates molecular subtypes of muscle-invasive bladder cancer.

Sci Rep 2020 Jul 2;10(1):10952. Epub 2020 Jul 2.

Division of Molecular Carcinogenesis, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Muscle-invasive bladder cancer (MIBC) is a heterogeneous disease that often recurs despite aggressive treatment with neoadjuvant chemotherapy and (radical) cystectomy. Basal and luminal molecular subtypes have been identified that are linked to clinical characteristics and have differential sensitivities to chemotherapy. While it has been suggested that epigenetic mechanisms play a role in defining these subtypes, a thorough understanding of the biological mechanisms is lacking. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1038/s41598-020-67850-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331601PMC

Practice patterns for extended venous thromboembolism chemoprophylaxis among urologic oncologists after radical cystectomy.

Urol Oncol 2020 Jun 29. Epub 2020 Jun 29.

Department of Urology, MedStar Georgetown University Hospital, Washington, DC; Department of Urology, MedStar Washington Hospital Center, Washington, DC. Electronic address:

Introduction: Extended outpatient chemoprophylaxis (ECP) following radical cystectomy (RC) for bladder cancer is proven to reduce rates of venous thromboembolism (VTE). While ECP is commonly performed with enoxaparin, its cost-effectiveness and adherence rate has been called into question. Data from orthopedic literature suggest that ECP with direct oral anticoagulants (DOACs) may be as effective in VTE prevention as enoxaparin in patients undergoing joint surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2020.05.030DOI Listing

Impact of intraoperative hypotension on early postoperative acute kidney injury in cystectomy patients - A retrospective cohort analysis.

J Clin Anesth 2020 Jun 29;66:109906. Epub 2020 Jun 29.

Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, CH-3010 Bern, Switzerland. Electronic address:

Study Objective: To assess the risk for postoperative acute kidney injury (AKI) after major urologic surgery for different intraoperative hypotension thresholds in form of time below a fixed threshold. We hypothesize that the duration of hypotension below a certain hypotension threshold is a risk factor for AKI also in major urologic procedures.

Design: Retrospective observational cohort series. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jclinane.2020.109906DOI Listing

Coronavirus (COVID-19) Pandemic and Radical Cystectomy.

Eurasian J Med 2020 Jun;52(2):106-107

Departments of Urology, Ataturk University School of Medicine, Erzurum, Turkey.

View Article

Download full-text PDF

Source
http://dx.doi.org/10..5152/eurasianjmed.2020.010620DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7311139PMC

The Value of Multiparametric Magnetic Resonance Imaging Sequences to Assist in the Decision Making of Muscle-invasive Bladder Cancer.

Eur Urol Oncol 2020 Jun 27. Epub 2020 Jun 27.

Department of Medical Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy. Electronic address:

Interim data from the PURE-01 study, using pembrolizumab before radical cystectomy in muscle-invasive bladder cancer (MIBC), suggested that multiparametric magnetic resonance imaging (mpMRI) was able to predict the pathologic response. Owing to the availability of novel effective therapies in MIBC, the possibility to assess tumor response easily has become exceedingly important. The primary objective of the present study was to evaluate the association between individual and combined MRI sequences, and the pathologic response in the final PURE-01 population. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euo.2020.06.004DOI Listing

Posterior reconstruction during robotic-assisted radical cystectomy with intracorporeal orthotopic ileal neobladder: description and outcomes of a simple step.

J Robot Surg 2020 Jun 29. Epub 2020 Jun 29.

Department of Urology, Karolinska University Hospital, Stockholm, Sweden.

A posterior reconstruction (PR) might improve the fluidity and delicacy of the maneuvers related to the neovesico-urethral anastomosis during robotic-assisted radical cystectomy (RARC). Our objective is to describe in detail the surgical steps of PR and to assess its feasibility and functional outcomes. The data regarding patients undergoing a totally intracorporeal RARC with neobladder and PR for high-grade and/or muscle-invasive urothelial cancer of the bladder at Karolinska University Hospital between October 2015 and November 2016 by a single surgeon (PW) were reviewed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s11701-020-01108-0DOI Listing

Introduction: Personalizing risk stratification in bladder cancer: Moving away from "the eyeball test" and embracing objective quantification of risk.

Authors:
Sarah P Psutka

Urol Oncol 2020 Jun 27. Epub 2020 Jun 27.

Department of Urology, Seattle Cancer Care Alliance, University of Washington, Seattle, WA. Electronic address:

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2020.05.029DOI Listing

Impact of anemia on the survival of patients undergoing radical cystectomy for bladder cancer.

Actas Urol Esp 2020 Jun 26. Epub 2020 Jun 26.

Servicio de Urología, Consorci Corporació Sanitària Parc Taulí, Sabadell, Barcelona, España.

Objective: To evaluate the prevalence of preoperative anemia and its effect on oncological outcomes in patients undergoing radical cystectomy (RC) due to bladder cancer.

Material And Methods: Retrospective single-center study with 176 RCs between May 2008 and July 2018. Anemia was defined according to the WHO classification (male<130mg/dL, female<120mg/dL). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.acuro.2020.04.005DOI Listing

[Frequency of occurrence and risk factors for acute kidney injury after radical cystectomy].

Urologiia 2020 Jun(3):34-38

FGAOU VO I.M. Sechenov First Moscow State Medical University, Moscow, Russia.

Introduction: Various studies have revealed the negative impact of surgery or related factors on the risk of acute kidney injury (AKI). The risk factors and 6-months outcomes in patients with clinical or subclinical manifestations of AKI after radical cystectomy were analyzed.

Materials And Methods: This prospective study included patients with normal renal function who underwent radical cystectomy. Read More

View Article

Download full-text PDF

Source

Comparing peri-operative complications between laparoscopic and robotic radical cystectomy for bladder cancer.

J Endourol 2020 Jun 27. Epub 2020 Jun 27.

Institut Mutualiste Montsouris, 26953, Urology, Paris, Île-de-France, France;

Background: Minimally invasive cystectomy is being increasingly performed however, data comparing laparoscopic radical cystectomy (LRC) and robotic radical cystectomy (RRC) is scarce. We compared 30-day and 90-day Clavien-Dindo Classification(CDC) complications between patients undergoing LRC and RRC at our centre.

Materials And Methods: We retrospectively evaluated 300 patients who underwent minimally invasive radical cystectomy from January 2007 to July 2019 and grouped them into LRC (112 patients) and RRC (188 patients). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1089/end.2020.0112DOI Listing

Assessing CD 10 Expression Level and Its Prognostic Impact in Egyptian Patients with Urothelial Carcinoma.

Asian Pac J Cancer Prev 2020 Jun 1;21(6):1573-1583. Epub 2020 Jun 1.

Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background And Aim: CD10 is expressed in urothelial carcinoma cells and cancer associated fibroblasts (CAF). In the current study, CD10 immunohistochemical staining (IHC) and CD10 mRNA expression in urothelial carcinoma of bladder (UCB) were assessed, and its  relationship with tumor progression and prognosis was investigated.

Patients And Methods: In this study, 106 formalin fixed paraffin-embedded (FFPE) tissue of UCB, obtained through radical cystectomy specimen, and 10 matched normal tissue samples were included. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.31557/APJCP.2020.21.6.1573DOI Listing

Survival Outcomes of Patients with Pathologically Proven Positive Lymph Nodes at Time of Radical Cystectomy with or without Neoadjuvant Chemotherapy.

J Clin Med 2020 Jun 23;9(6). Epub 2020 Jun 23.

Department of Oncology, IUCT-O, 31000 Toulouse, France.

Background: To compare overall survival (OS) outcomes in pN1-3 disease at the time of radical cystectomy (RC) for muscle invasive bladder according to the neoadjuvant chemotherapy (NAC) status.

Materials And Methods: This multicenter study included 450 consecutive patients undergoing RC for muscle-invasive urothelial bladder cancer with pN1-3 pM0 disease from 2010 to 2019. NAC consisted in platinum-based chemotherapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3390/jcm9061962DOI Listing

[The impact of radical cystectomy on health-related quality of life and potential for optimisation].

Aktuelle Urol 2020 Jun 24. Epub 2020 Jun 24.

Universitätsklinikum Ulm, Klinik für Urologie und Kinderurologie, Ulm.

Radical cystectomy may have a major impact on the lives of affected patients. Older patients often have a reduced life expectancy after radical cystectomy. Therefore, aspects of health-related quality of life (HRQOL) have to be balanced against a solely tumour-directed therapy. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1171-1213DOI Listing

Clinically node-positive micropapillary bladder cancer in a young female desiring to spare functional bladder and fertility.

Int Cancer Conf J 2020 Jul 11;9(3):151-154. Epub 2020 Apr 11.

Department of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-ku, Tokyo, 113-8677 Japan.

A 38-year-old female developing pelvic lymph node recurrence (cN2) of bladder cancer was referred to our hospital. Eighteen months earlier, she had received complete transurethral resection of bladder tumor and pathological diagnosis of muscle-invasive urothelial carcinoma with micropapillary variant had been made. She had declined radical cystectomy or chemoradiation because of a strong desire to spare the bladder and fertility. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1007/s13691-020-00415-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7297927PMC

The Impact of Centralised Services on Metric Reflecting High-quality Performance: Outcomes from 1110 Consecutive Radical Cystectomies at a Single Centre.

Eur Urol Focus 2020 Jun 21. Epub 2020 Jun 21.

Academic Urology Unit, University of Sheffield, Sheffield, UK; Department of Urology, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, UK. Electronic address:

Background: The 2002 National Institute for Health and Care Excellence guidance on centralisation of radical cystectomy (RC) coincided with changes in practice: use of neoadjuvant chemotherapy (NAC) and pelvic lymph node dissection (PLND), and RC for high-risk non-muscle-invasive bladder cancer (HR-NMIBC).

Objective: To report the outcomes of RC at a single centre and to compare trends in survival with respect to centralisation and change in RC practice.

Design, Setting, And Participants: Data were collected retrospectively between 1 January 1994 and 31 December 2016. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euf.2020.05.011DOI Listing

D2-40/podoplanin expression in cancer stroma by immunohistochemical staining is associated with poor prognosis in bladder cancer patients after radical cystectomy.

Urol Oncol 2020 Jun 20. Epub 2020 Jun 20.

West Japan Urologic Oncology Consortium, Japan; Department of Urology, Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Toyama, Japan.

Objectives: We assessed whether D2-40/podoplanin (PDPN) could be used to identify bladder cancer patients with a higher probability of benefiting from cisplatin-based combination chemotherapy.

Patients And Methods: We investigated PDPN expression by immunohistochemical analysis of cystectomy specimens from 96 bladder cancer patients who had undergone radical cystectomy without neoadjuvant or adjuvant cisplatin-based combination chemotherapy until recurrence. We classified the cases into 2 groups according to the achievement of 2-year recurrence-free survival (RFS) and evaluated whether PDPN expression was associated with patient prognosis. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.urolonc.2020.05.020DOI Listing

[Application of Endo-GIA stapler in laparoscopic radicalcystectomy].

Zhonghua Yi Xue Za Zhi 2020 Jun;100(24):1872-1876

Department of Urology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.

To explore the application of Endo-GIA stapler in laparoscopic radical cystectomy, especially in the treatment of lateral bladder ligament, and to evaluate its clinical feasibility and practicability. A retrospective analysis of clinical data about 38 cases of laparoscopic radical cystectomy (LRC) treated in the Department of Urology, Chaoyang Hospital of Beijing and Cancer Hospital, Chinese Academy of Medical Sciences from July 2017 to June 2019 were conducted. The patients were divided into Endo-GIA stopler group(18 cases) and non-Endo-GIA stopler group (20 cases) according to whether Endo-GIA stapler were used. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.cn112137-20190925-02112DOI Listing

Surgical Pathology Findings in Patients Who Have Undergone Radical Cystectomy/Cystoprostatectomy With Extended Versus Standard Lymph Node Dissection for Urothelial Carcinoma of the Bladder: A Contemporary Analysis.

Int J Surg Pathol 2020 Jun 23:1066896920937072. Epub 2020 Jun 23.

Emory University, Atlanta, GA, USA.

Radical cystectomy/cystoprostatectomy with pelvic lymph node dissection (with or without neoadjuvant chemotherapy) is the gold standard in the management of patients with urothelial carcinoma (UCa) with muscularis propria (detrusor muscle) invasion. However, it remains controversial how extensive the lymph node dissection should be. In this article, we analyzed the clinicopathologic findings in patients who had radical cystectomy/cystoprostatectomy with extended versus standard lymph node dissection. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/1066896920937072DOI Listing

Canadian experience of neoadjuvant chemotherapy on bladder recurrences in patients managed with trimodal therapy for muscle-invasive bladder cancer.

Can Urol Assoc J 2020 Jun 16. Epub 2020 Jun 16.

Division of Urology, Departments of Surgery and Surgical Oncology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, ON, Canada.

Introduction: Bladder preservation with trimodal therapy (TMT) has emerged as a feasible alternative to radical cystectomy in patients with muscle-invasive bladder cancer. Neoadjuvant chemotherapy (NAC) was proven to cause pathological downstaging. For this reason, we evaluated whether receipt of NAC decreases local bladder recurrences in TMT patients. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5489/cuaj.6459DOI Listing

Factors predicting early mortality after radical cystectomy for urothelial carcinoma in a contemporary cohort of patients.

Can Urol Assoc J 2020 Jun 16. Epub 2020 Jun 16.

Department of Urology, Dalhousie University, Halifax, NS.

Introduction: We aimed to identify preoperatively available patient variables associated with increased mortality within 30 and 90 days of radical cystectomy (RC) for localized urothelial carcinoma (UC), and to evaluate temporal trends in early mortality rates.

Methods: We reviewed the National Cancer Database to identify patients who underwent RC for UC between 2006 and 2013. Preoperatively available patient-specific demographics and mortality rates at 30 and 90 days postoperatively were analyzed. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.5489/cuaj.6400DOI Listing

Validation of the effectiveness of a modified Studer orthotopic neobladder in a single center after 3 years of its application.

Urologia 2020 Jun 20:391560320930115. Epub 2020 Jun 20.

Department of Urology, San Giuseppe Hospital, Multimedica Group, Milan, Italy.

Introduction And Objective: In this study, we reported the 2 years outcomes of orthotopic neobladder diversion according to the Studer modified technique described by Bianchi G. et al. This technique improves the stability of the reservoir and the urine-storage capacity. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0391560320930115DOI Listing

Role of lymph node dissection in radical cystectomy.

Oncol Lett 2020 Jul 21;20(1):409-419. Epub 2020 Apr 21.

Department of Urology, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China.

The number of lymph node dissections (LNDs) is an independent factor influencing the survival time of patients with bladder cancer (BCa) after radical resection (RC). The present study aimed to investigate the association between the number of LNDs and the survival of patients with BCa at different stages and who underwent RC in the United States of America and China. Records from 17,730 American patients with BCa and 158 Chinese patients with BCa were collected from the Surveillance, Epidemiology and End Results (SEER) and the Shanghai Tenth People's Hospital (China) databases, respectively. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3892/ol.2020.11563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285989PMC

An International Survey on the Use of Thromboprophylaxis in Urological Surgery.

Eur Urol Focus 2020 Jun 16. Epub 2020 Jun 16.

Departments of Urology and Public Health, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. Electronic address:

Background: The use of perioperative thromboprophylaxis in urological surgery is common but not standardized.

Objective: To characterize international practice variation in thromboprophylaxis use in urological surgery.

Design, Setting, And Participants: We conducted a scenario-based survey addressing the use of mechanical and pharmacological thromboprophylaxis in urological cancer procedures (radical cystectomy [RC], radical prostatectomy [RP], and radical nephrectomy [RN]) among practicing urologists in Canada, Finland, and Japan. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euf.2020.05.015DOI Listing

The Utility and Efficacy of Laparoscopic Radical Cystectomy in Patients with Muscle-Invasive Bladder Cancer at a Single Institution.

Urol Int 2020 Jun 17:1-7. Epub 2020 Jun 17.

Department of Urology, Gifu University Graduate School of Medicine, Gifu, Japan,

Background: The aim of this study was to compare the surgical and oncological outcomes and complications of laparoscopic radical cystectomy (LRC) to those of open radical cystectomy (ORC) in patients with muscle-invasive bladder cancer (MIBC).

Methods: Our study focused on patients with histologically confirmed stage T2-T4a urothelial carcinoma of the bladder without distant metastases, who underwent LRC (LRC group) or ORC (ORC group). The primary endpoints in this study were the overall survival (OS) and recurrence-free survival (RFS) rates. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000508192DOI Listing

Cutting-edge Management of Muscle-invasive Bladder Cancer in 2020 and a Glimpse into the Future.

Eur Urol Oncol 2020 Jun 15. Epub 2020 Jun 15.

Sorbonne University, GRC 5 Predictive ONCO-URO, AP-HP, Urology, Pitié-Salpêtrière Hospital, Paris, France. Electronic address:

This case-based discussion describes the clinical course of a 63-yr-old patient who presented with gross hematuria and was diagnosed with a muscle-invasive bladder cancer at transurethral resection. Computed tomography revealed a locally advanced tumor, and the patient underwent neoadjuvant chemotherapy followed by open radical cystectomy with standard pelvic lymph node dissection. In a step-by-step fashion, we elaborate on diagnostic and therapeutic treatment options from two different vantage points: (1) guideline-adherent treatment with the state-of-the-art standard of care, and (2) a glimpse into the future discussing the evidence of potential additional or alternative approaches based on recent scientific advances. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euo.2020.06.001DOI Listing

Forecasting the Future of Urology Practice: A Comprehensive Review of the Recommendations by International and European Associations on Priority Procedures During the COVID-19 Pandemic.

Eur Urol Focus 2020 May 31. Epub 2020 May 31.

Division of Urology, Department of Oncology, School of Medicine, San Luigi Hospital, University of Turin, Orbassano, Turin, Italy. Electronic address:

Context: The unprecedented health care scenario caused by the coronavirus disease 2019 (COVID-19) pandemic has revolutionized urology practice worldwide.

Objective: To review the recommendations by the international and European national urological associations/societies (UASs) on prioritization strategies for both oncological and nononcological procedures released during the current emergency scenario.

Evidence Acquisition: Each UAS official website was searched between April 8 and 18, 2020, to retrieve any document, publication, or position paper on prioritization strategies regarding both diagnostic and therapeutic urological procedures, and any recommendations on the use of telemedicine and minimally invasive surgery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.euf.2020.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7261455PMC

Intracorporeal versus extracorporeal urinary diversion after robotic-assisted radical cystectomy: evidence from a systematic review and pooled analysis of observational studies.

Minerva Urol Nefrol 2020 Jun 16. Epub 2020 Jun 16.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China -

Introduction: To compare the perioperative, pathological and oncological outcomes of patients undergoing extracorporeal urinary diversion (EUD) and intracorporeal urinary diversion (IUD) following robot-assisted radical cystectomy (RARC).

Evidence Acquisition: Multiple scientific databases were searched up to January 2020 for comparative studies comparing IUD and EUD. The data was analyzed by Review Manager 5. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.23736/S0393-2249.20.03829-1DOI Listing

Randomized controlled trial to compare outcomes with and without the enhanced recovery after surgery protocol in patients undergoing radical cystectomy.

Indian J Urol 2020 Apr-Jun;36(2):95-100. Epub 2020 Apr 7.

Department of Urology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.

Introduction: Very few randomized controlled trials are available globally to support routine use of enhanced recovery after surgery (ERAS) protocol after radical cystectomy (RC), and none so far has been conducted in the Indian subcontinent. The aim of the present study was to evaluate hospital stay and 30-day perioperative outcomes following RC with the implementation of the ERAS protocol.

Materials And Methods: Fifty-four patients undergoing open RC were randomized to ERAS versus conventional surgical care (CSC) at our center from April 2017 to May 2018. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.4103/iju.IJU_11_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7279092PMC

Neoadjuvant therapy for muscle-invasive bladder cancer.

Expert Rev Anticancer Ther 2020 Jun 30:1-12. Epub 2020 Jun 30.

Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute , Boston, MA, USA.

Introduction: Muscle-invasive bladder cancer (MIBC) is generally a highly aggressive malignancy with early and mostly distant recurrences. Cisplatin-based combinations have been established as neoadjuvant chemotherapy (NAC) prior to radical cystectomy (RC) providing overall survival as well as disease-free survival benefit. Immune checkpoint inhibitors (ICIs) have revolutionized the treatment of metastatic urothelial carcinoma and are being tested in the neoadjuvant setting as well. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/14737140.2020.1784011DOI Listing

Transvaginal Enterocele and Evisceration Repair After Radical Cystectomy Using Porcine Xenograft.

Female Pelvic Med Reconstr Surg 2020 Jul;26(7):e19-e22

Department of Gynecologic Surgery, Mayo Clinic, Jacksonville, FL.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1097/SPV.0000000000000889DOI Listing

Validation of a Questionnaire-Suitable Comorbidity Index in Patients Undergoing Radical Cystectomy.

Urol Int 2020 Jun 15:1-6. Epub 2020 Jun 15.

Department of Urology, University Hospital "Carl Gustav Carus", Technische Universität Dresden, Dresden, Germany.

Objective: To investigate the capability of a modified self-administrable comorbidity index recommended in the standard sets for neoplastic diseases published by the International Consortium for Health Outcomes Measurement (ICHOM) to predict 90-day and long-term mortality after radical cystectomy.

Methods: A single-center series of 1,337 consecutive patients who underwent radical cystectomy for muscle-invasive or high-risk non-muscle-invasive urothelial or undifferentiated bladder cancer were stratified by the modified self-administrable comorbidity index and Charlson score, respectively. Multivariate logit models (for 90-day mortality) and proportional-hazards models (for overall and non-bladder cancer mortality) were used for statistical workup. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1159/000507100DOI Listing

Delayed blood transfusion is associated with mortality following radical cystectomy.

Scand J Urol 2020 Jun 13:1-7. Epub 2020 Jun 13.

Division of Urological Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

To examine the temporal association between blood transfusion and 90-day mortality in patients with bladder cancer treated with radical cystectomy. This represents a retrospective cohort study of patients treated with radical cystectomy within the Premier Hospital network between 2003 and 2015. Patients outcomes were stratified those who received early blood transfusion (day of surgery) vs delayed blood transfusion (postoperative day ≥1) during the index admission. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1080/21681805.2020.1777195DOI Listing