8,822 results match your criteria Cystectomy Radical


Combination of AST to ALT and neutrophils to lymphocytes ratios as predictors of locally advanced disease in patients with bladder cancer subjected to radical cystectomy: Results from a single-institutional series.

Urologia 2021 Aug 4:3915603211035191. Epub 2021 Aug 4.

IRCCS Humanitas Research Hospital, Rozzano, Milan, Italy.

Background: Bladder cancer (BC) staging is challenging. There is an important need for available and affordable predictors to assess, in combination with imaging, the presence of locally-advanced disease.

Objective: To determine the role of the De Ritis ratio (DRR) and neutrophils to lymphocytes ratio (NLR) in the prediction of locally-advanced disease defined as the presence of extravescical extension (pT ⩾ 3) and/or lymph node metastases (LNM) in patients with BC treated with radical cystectomy (RC). Read More

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Oncologic Outcomes for Robotic Vs. Open Radical Cystectomy Among Locally Advanced and Node-Positive Patients: Analysis of The National Cancer Database.

Clin Genitourin Cancer 2021 Jul 10. Epub 2021 Jul 10.

Department of Urology, George Washington University School of Medicine and Health Sciences.

Introduction: Despite concerns of atypical recurrence following robotic-assisted radical cystectomy (RARC), utilization of the modality is increasing. The presumed mechanisms of peritoneal immunomodulation and pneumoperitoneum-induced tumor cell intravasation are especially relevant for higher stage, locally advanced disease, where intrinsic metastatic potential of tumor cells may be greater. This study aims to compare the oncologic outcomes and survival after RARC compared to open radical cystectomy (ORC) among patients with stage pT3-4 or node-positive muscle-invasive bladder cancer. Read More

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Psychological resilience of patients with bladder cancer after radical cystectomy and urinary diversion: a cross-sectional study.

Psychooncology 2021 Aug 3. Epub 2021 Aug 3.

Department of Urinary Surgery, the First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China, 110000.

Objective: The aims of this study were to investigate the current state of psychological resilience and identify its associated factors in bladder cancer (BC) patients undergoing radical cystectomy (RC).

Methods: A cross-sectional study, using convenience sampling was conducted among 248 patients recruited from urology department of a tertiary hospital in Shenyang, China. According to the resilience in illness model, participants were invited to finish a questionnaire included demographic and disease-related information, Connor-Davidson Resilience Scale, Mishel Uncertainty in Illness Scale, Medical Coping Modes Questionnaire, Social Support Rating Scale, Family APGAR Index and Herth Hope Index. Read More

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Modified completely intrafascial radical cysprostatectomy for bladder cancer: a single-center, blinded, controlled study.

BMC Cancer 2021 Aug 3;21(1):887. Epub 2021 Aug 3.

Department of Urology, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuhan, 430060, P.R. China.

Background: We have proposed a modified, completely intrafascial radical cysprostatectomy (RC) to treat bladder cancer patients with the aim of preserving the patients' post-surgical urinary control and erectile function. This study aimed to evaluate the oncological and functional outcomes of this innovation relatively to that with the conventional technique.

Methods: A retrospective, single-center, blinded, and controlled study was conducted using the medical data of patients since the past 5 years from the hospital database. Read More

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Neoadjuvant Immunotherapy: The Next Gold Standard Before Radical Surgery for Urothelial Cancer.

Eur Urol Open Sci 2021 Aug 21;30:34-36. Epub 2021 Jun 21.

Medical Oncology Department, IRCCS Ospedale San Raffaele, Milan, Italy.

Cisplatin-based chemotherapy followed by radical cystectomy with bilateral pelvic lymph-node dissection is the current standard for cT2-4a N0 M0 urothelial bladder cancer. Immune checkpoint inhibitors have recently been tested in the neoadjuvant setting with promising pathological and survival results and a better safety profile. Excellent pathological responses have been observed, especially in cases with higher clinical T stage and PD-L1 expression, in addition to patients with selected gene signatures. Read More

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Outcomes for Muscle-invasive Bladder Cancer with Radical Cystectomy or Trimodal Therapy in US Veterans.

Eur Urol Open Sci 2021 Aug 9;30:1-10. Epub 2021 Jun 9.

Division of Hematology-Oncology, Department of Internal Medicine, University of California San Diego, La Jolla, CA, USA.

Background: Muscle-invasive bladder cancer (MIBC) remains undertreated despite multiple potentially curative options. Both radical cystectomy (RC) with or without neoadjuvant chemotherapy and trimodal therapy (TMT), including transurethral resection of bladder tumor followed by chemoradiotherapy, are standard treatments.

Objective: To evaluate real-world clinical outcomes of RC with neoadjuvant chemotherapy (RC-NAC), RC without NAC, TMT with National Comprehensive Cancer Network guideline-preferred radiosensitizing chemotherapy including cisplatin or mitomycin-C and 5-fluorouracil (pTMT), and TMT with nonpreferred chemotherapy (npTMT). Read More

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Decreasing Non-bladder-cancer Mortality After Radical Cystectomy.

Eur Urol Open Sci 2021 Jul 18;29:15-18. Epub 2021 May 18.

Department of Urology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.

Life expectancy is increasing in many parts of the world. Using proportional hazard models for competing risks, we investigated whether this increase has changed outcomes after radical cystectomy in a sample of 1419 consecutive patients treated between 1993 and 2018. During the observation period, the mean age and the proportion of patients with American Society of Anesthesiologists physical status class 3 or 4 increased, whereas the proportion of patients with heart disease decreased. Read More

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Morbidity and Days Alive and Out of Hospital Within 90 Days Following Radical Cystectomy for Bladder Cancer.

Eur Urol Open Sci 2021 Jun 19;28:1-8. Epub 2021 Apr 19.

Department of Urology, Rigshospitalet University Hospital, Copenhagen, Denmark.

Background: Morbidity after radical cystectomy (RC) is usually quantified in terms of rates of complications, mortality, reoperations, and readmissions, and length of stay (LOS). The overall burden following RC within the first 90 d following RC may be better described using days alive and out of hospital (DAOH), which is a validated, patient-centred proxy for both morbidity and mortality.

Objective: To report short-term morbidity, LOS, and DAOH within 90 d after RC and risk factors associated with these parameters. Read More

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Intensified and Standardized Digital Communication with Cystectomy Patients as a Potentially Simple and Effective Modality for Early Detection of Postoperative Complications: Results from a Pilot Study.

Eur Urol Open Sci 2020 Dec 24;22:3-8. Epub 2020 Oct 24.

Urologie St. Anna, Luzern, Switzerland.

Background: Postoperative readmission rates following radical cystectomy remain significant. Early identification of emerging complications could potentially allow for immediate institution of therapy.

Objective: To intensify postoperative patient-physician communication via a cellphone-based health care application (CHA) and to evaluate its potential for early detection of complications. Read More

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December 2020

A Prospective, Observational, Multicentre Study Concerning Nontechnical Skills in Robot-assisted Radical Cystectomy Versus Open Radical Cystectomy.

Eur Urol Open Sci 2020 Jul 3;19:37-44. Epub 2020 Jul 3.

Netherlands Institute for Health Services Research (NIVEL), Utrecht, The Netherlands.

Introduction And Hypotheses: valuation of surgical skills, both technical and nontechnical, is possible through observations and video analysis. Besides technical failures, adverse outcomes in surgery can also be related to hampered communication, moderate teamwork, lack of leadership, and loss of situational awareness. Even though some surgeons are convinced about nontechnical skills being an important part of their professionalisation, there is paucity of data about a possible relationship between nontechnical skills and surgical outcome. Read More

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Impact of Diagnosing Urologists and Hospitals on the Use of Radical Cystectomy.

Eur Urol Open Sci 2020 Jul 23;19:27-36. Epub 2020 Jun 23.

Department of Surgery, Division of Urology, The University of Texas Medical Branch, Galveston, TX, USA.

Background: One out of five patients with muscle-invasive bladder cancer undergo radical cystectomy-a guideline-recommended treatment. Previous studies have primarily evaluated patient characteristics associated with the use of radical cystectomy, ignoring potential nesting of data.

Objective: To determine the impact of patient, diagnosing urologist, and hospital characteristics on the variation in the use of radical cystectomy. Read More

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Tumour Behaviour of Low-Grade Papillary Urothelial Carcinoma: A Single-Centre Retrospective Study.

Cureus 2021 Jun 29;13(6):e16012. Epub 2021 Jun 29.

Urology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, IND.

Background and objective Carcinoma of the urinary bladder is the most common urological cancer, and it accounts for 3.9% of all cancer cases in men. Patients with the subset of noninvasive low-grade papillary urothelial carcinoma (LG-UrCa) are at higher risk for tumour recurrence. Read More

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Robotic radical cystectomy and bilateral nephrectomy in a renal transplant patient: the indocyanine green technique.

Cent European J Urol 2021 5;74(2):272-273. Epub 2021 May 5.

S.H. Ho Urology Centre, Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong.

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Orthotopic MAINZ pouch bladder substitution - long-term follow-up.

Cent European J Urol 2021 19;74(2):235-240. Epub 2021 Apr 19.

Department of Pediatric, Adolescent and reconstructive Urology, University Medical Center Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.

Introduction: After radical cystectomy, orthotopic neobladder is one surgical strategy for urinary diversion. To assess the usefulness of an operation, long-term data are essential. We examined long-term complications and continence rates of orthotopic ileocecal (MAINZ pouch) bladder substitution. Read More

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Oncological outcomes of concomitant carcinoma in situ at radical cystectomy in pure urothelial bladder cancer and in histological variants.

Urol Oncol 2021 Jul 29. Epub 2021 Jul 29.

Department of Urology, ASST Papa Giovanni XXIII, Bergamo, Italy; University of Milano-Bicocca, Milan, Italy.

Introduction: The presence of carcinoma in situ at transurethral resection is known to increase the risk of recurrence and progression to invasive disease. However, the evidence regarding the prognostic role of concomitant carcinoma in situ after radical cystectomy due to bladder cancer is controversial. Moreover, concomitant carcinoma in situ was found to be significantly associated with bladder histological variants. Read More

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Evaluating the impact of the learning curve on the perioperative outcomes of robot-assisted radical cystectomy with intracorporeal urinary diversion.

Actas Urol Esp 2021 Jul 29. Epub 2021 Jul 29.

Departamento de Urología, Hospital Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, España.

Introduction: Robot-assisted radical cystectomy (RARC) with intracorporeal urinary diversion (ICUD) is a technically difficult procedure. Our aim was to evaluate the potential impact of the learning curve (LC) on perioperative and pathological outcomes of RARC with ICUD.

Material And Methods: Retrospective study of 62 consecutive patients who underwent RARC with ICUD for bladder cancer between 2015-2020. Read More

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A 25-year perspective on advances in an understanding of the biology, evaluation, treatment and future directions/challenges of urothelial cancer.

Urol Oncol 2021 Jul 28. Epub 2021 Jul 28.

Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.

The Urologic Oncology Journal was founded 25 years ago and we reviewed the literature since that time in the area of urothelial cancer to see the progress and pitfalls we have made over this time period. A comprehensive literature search was conducted by the authors involved who are all actively involved in research, clinical trials, and treatment for urothelial cancer and the results were summarized over the past 25 years. The field of urothelial cancer has evolved tremendously in the last 25 years with the incorporation of molecular subtyping, novel imaging, immunotherapy, and robotic surgery. Read More

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Recurrence and treatment of adult primary nonmetastatic bladder rhabdomyosarcoma: A systematic review.

Urol Oncol 2021 Jul 28. Epub 2021 Jul 28.

The George Washington University School of Medicine, Washington, District of Columbia.

Introduction: While survival for pediatric bladder rhabdomyosarcoma (RMS) has recently improved with risk-based multimodality treatment protocols, survival for adult bladder RMS remains to be poor. Survival is poor likely because adult bladder RMS is rare, understudied, and consequently lacking in high-level evidence to inform standardization of treatment. In addition, adult bladder RMS exhibits high rates of recurrence. Read More

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Superselective vesical artery embolization versus intravesical formalin for intractable hematuria in patients with bladder cancer.

Actas Urol Esp 2021 Jul 28. Epub 2021 Jul 28.

Department of Urology, Erciyes University, Kayseri, Turquía. Electronic address:

Objective: Intractable hematuria is a leading critical problem occurring in patients with advanced stage bladder cancer (BCa) that are not suitable for radical cystectomy. The present study, for the first time in the literature, aimed to compare the effectiveness of intravesical formalin (IF) and superselective vesical artery embolization (SVAE) in the management of intractable and life-threatening hematuria in BCa patients.

Methods: The retrospective study included 40 BCa patients who underwent SVAE or IF treatment due to intractable hematuria after failure of other methods. Read More

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Primary urethral carcinoma: Results from a single center experience.

Actas Urol Esp 2021 Jul 28. Epub 2021 Jul 28.

Departamento de Urología, Fundació Puigvert, Universidad Autónoma de Barcelona, Barcelona, España.

Introduction And Aim Of The Study: Primary urethral carcinoma (PUC) is a rare neoplastic disease arising in the urethra, without any evidence of a previous or synchronous carcinoma of the entire urinary tract. Since rare diseases are often incorrectly diagnosed and managed, the aim of this study was to analyze the experience of a single urology center in the treatment of PUC, focusing on neoplasms arising from the male anterior urethra.

Materials And Methods: Medical records of patients with neoplasms at the level of the penile and bulbar urethra who presented at our tertiary referral center between January 1988 and December 2018 were retrospectively reviewed. Read More

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Ureteroileal anastomosis stricture after urinary diversions performed by open, laparoscopic and robotic approaches. Incidence and management in a tertiary care center.

Actas Urol Esp 2021 Jul 28. Epub 2021 Jul 28.

Servicio de Urología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España; Instituto de Investigación Sanitaria Valdecilla (IDIVAL), Santander, Cantabria, España; Facultad de Medicina, Universidad de Cantabria, Santander, Cantabria, España.

Introduction: Ureteroileal anastomosis stricture is a frequent complication after radical cystectomy and ileal conduit or orthotopic neobladder formation. We analyze their incidence based on the technique for urinary diversion and on the surgical approach (open, laparoscopic or robot-assisted). Stricture management is described, along with surgical outcomes. Read More

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Intranodal Lymphangiography during Surgical Repair of Pelvic Lymphorrhea after Radical Cystectomy.

Case Rep Urol 2021 5;2021:7822422. Epub 2021 Jul 5.

Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Japan.

Lymphorrhea can develop after various types of surgeries. Surgical closure of the lymphatic leakage point is an effective treatment option. However, it is difficult to identify the leakage point sometimes. Read More

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Outcomes following open radical cystectomy: an 11-year Christchurch experience.

N Z Med J 2021 Jul 30;134(1539):63-73. Epub 2021 Jul 30.

Statistician, University of Otago, Christchurch, New Zealand.

Background: Radical cystectomy (RC) remains the standard approach to treating muscle invasive bladder cancer. Despite improvements in surgical and anaesthetic care, morbidity and mortality remain high. In the United Kingdom, centralisation has improved outcomes following RC. Read More

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Primary left ovarian hydatid cyst presenting as an abdominal mass - Case report.

Int J Surg Case Rep 2021 Jul 21;85:106230. Epub 2021 Jul 21.

Kabul University of Medical Sciences, Department of Emergency Surgery & Trauma, Ali Abad Teaching Hospital, Kabul, Afghanistan.

Introduction: Hydatid disease, which is most often caused by Echinococcus granulosus, can occur in virtually all parts of the body. The disease most frequently occurs in the liver followed by the lungs, muscles, and bones respectively. Primary ovarian hydatid cyst is a rare case. Read More

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Bacillus Calmette-Guérin-unresponsive non-muscle invasive bladder cancer outcomes in patients without radical cystectomy.

Int J Clin Oncol 2021 Jul 27. Epub 2021 Jul 27.

Department of Urology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.

Background: Bacillus Calmette-Guérin (BCG)-unresponsive non-muscle invasive bladder cancer (NMIBC) is a newly defined subtype that is unlikely to benefit from BCG rechallenge. Radical cystectomy is currently recommended for BCG-unresponsive NMIBC; however, a certain proportion of these patients can be managed with treatments other than that. Herein, we conducted a multicenter retrospective study to analyze the clinical outcomes of BCG-unresponsive NMIBC patients who did not receive radical cystectomy. Read More

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Quality of life following formation of an ileal conduit due to urinary bladder neoplasm: A systematic review.

Int J Nurs Pract 2021 Jul 27:e12988. Epub 2021 Jul 27.

Department of Nursing and Midwifery, University of Limerick, Limerick, Ireland.

Aim: To present the findings of a systematic review on reported quality of life following the formation of a urinary diversion as a result of cystectomy due to urinary bladder neoplasm.

Background: Bladder cancer is the most commonly occurring cancer of the urological system. Treatment often involves undergoing a radical cystectomy with an ileal conduit formation. Read More

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Cumulative incidence of ureteroenteric strictures after radical cystectomy in a population-based Swedish cohort.

Scand J Urol 2021 Jul 27:1-5. Epub 2021 Jul 27.

Department of Urology, Sahlgrenska University Hospital, Gothenburg, Sweden.

Objective: The incidence of benign ureteroenteric strictures following radical cystectomy (RC) for urinary bladder cancer (UBC) is investigated mainly in single-centre studies from high-volume centres. The aim of this study was to evaluate the cumulative incidence of strictures and risk factors in a population-based cohort.

Patients And Methods: Data was collected from Bladder Cancer Data Base Sweden (BladderBaSe). Read More

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Variables affecting quality of life after Radical cystectomy and neobladder substitution: Egyptian National Cancer Institute experience.

Prog Urol 2021 Jul 23. Epub 2021 Jul 23.

Department of Surgical Oncology, Cairo University, National Cancer Institute, Cairo, Egypt. Electronic address:

Introduction: To evaluate the functional outcomes and quality of life beyond 1 year, in patients treated with radical cystectomy and orthotopic diversion for invasive bladder cancer. To investigate various potential contributing factors on patient's quality of life after radical cystectomy and urinary diversion via orthotopic neobladder.

Materials And Methods: This retrospective study was conducted at the National Cancer Institute (NCI), Cairo; including a total of 97 patients who underwent radical cystectomy and orthotopic diversion. Read More

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Contemporary management of benign uretero-enteric strictures after cystectomy: a systematic review.

Minerva Urol Nephrol 2021 Jul 26. Epub 2021 Jul 26.

Urology Department, Sant'Andrea Hospital, Università degli Studi di Roma La Sapienza, Rome, Italy.

Introduction: Uretero-enteric stricture (UES) is a common post-operative complication after radical cystectomy with urinary diversion. The aim of this systematic review is to discuss the contemporary management of benign UES after cystectomy and to compare the different surgical approaches.

Evidence Acquisition: A systematic review was performed from January 2000 through January 2021. Read More

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Randomized Controlled Trial of Laparoscopic versus Open Radical Cystectomy in a Laparoscopic Naïve Center.

Adv Urol 2021 7;2021:4731013. Epub 2021 Jul 7.

National Cancer Institute, Cairo University, Department of Surgical Oncology, Cairo, Egypt.

Background: Laparoscopic radical cystectomy is a challenging surgical procedure; however, it has been largely abandoned in favor of the more intuitive robotic-assisted cystectomy. Due to the prohibitive cost of robotic surgery, the adoption of laparoscopic cystectomy is of relevance in low-resource institutes. . Read More

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