15,149 results match your criteria Cystectomy Radical


The expression profile of p14, p53 and p21 in tumour cells is associated with disease-specific survival and the outcome of postoperative chemotherapy treatment in muscle-invasive bladder cancer.

Urol Oncol 2018 Dec 24;36(12):530.e7-530.e18. Epub 2018 Oct 24.

Department of Pathology and Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University, SE 581 85, Linköping, Sweden.

Purpose: We investigated the effects of alterations in the biological markers p14, p53, p21, and p16 in relation to tumour cell proliferation, T-category, N- category, lymphovascular invasion, and the ability to predict prognosis in patients with muscle-invasive bladder cancer (MIBC) treated with cystectomy and, if applicable, chemotherapy.

Materials And Methods: We prospectively studied patients with urinary bladder cancer pathological stage pT1 to pT4 treated with cystectomy, pelvic lymph node dissection and postoperative chemotherapy. Tissue microarrays from paraffin-embedded cystectomy tumour samples were examined for expression of immunostaining of p14, p53, p21, p16 and Ki-67 in relation to other clinical and pathological factors as well as cancer-specific survival. Read More

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December 2018

A validated algorithm to identify recurrence of bladder cancer: a register-based study in Denmark.

Clin Epidemiol 2018 26;10:1755-1763. Epub 2018 Nov 26.

Research Centre for Cancer Diagnosis in Primary Care (CaP), Research Unit for General Practice, Department of Public Health, Aarhus University, 8000 Aarhus C, Denmark,

Purpose: Recurrence of cancer is not routinely registered in the national registers in Denmark. The aim of this study was to develop and validate a register-based algorithm to identify patients diagnosed with recurrence of invasive bladder cancer (BC).

Materials And Methods: We performed a cohort study based on data from Danish national health registers. Read More

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November 2018

Clinical utility and concordance of upper urinary tract cytology and biopsy in predicting Clinicopathologic features of upper urinary tract urothelial carcinoma.

Hum Pathol 2018 Dec 8. Epub 2018 Dec 8.

Department of Pathology, University of Michigan, 2800 Plymouth Road, Building 35, Ann Arbor, MI 48109, USA; Michigan Center for Translational Pathology, 5309 CCC 5940, 1500 E. Medical Center Drive, Ann Arbor, MI, 48109, USA; Comprehensive Cancer Center, University of Michigan Medical School, 1500 E Medical Center Drive, Ann Arbor, MI, 48109, USA. Electronic address:

5% of urothelial carcinoma occurs in the upper urinary tract (UUT), a challenging location to biopsy. We aim to evaluate concordance between biopsy, cytology, and resection specimens in a large upper tract urothelial carcinoma (UTUC) cohort.117 UTUC resections with UUT biopsy and/or cytology specimens from 2000-2016 were retrieved; pathologic material was re-reviewed, evaluated for concordance, and correlated with clinical information. Read More

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December 2018

Updates on the use of intravesical therapies for non-muscle invasive bladder cancer: how, when and what.

World J Urol 2018 Dec 7. Epub 2018 Dec 7.

H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA.

Introduction: Intravesical therapy has been an important aspect of the management of non-muscle invasive bladder cancer (NMIBC) for 40 years. Bacillus Calmette-Guerin (BCG) is considered standard of care for intermediate and high-grade non-invasive disease, yet understanding the nuances of subsequent intravesical therapy is important for any provider managing bladder cancer. Herein, we review the literature and describe optimal use of intravesical therapies for NMIBC. Read More

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December 2018

Positive ureteric margins at radical cystectomy: Can it be predicted at initial transurethral resection of bladder tumour?

Arab J Urol 2018 Dec 14;16(4):386-390. Epub 2018 Jul 14.

Department of Urology, Christian Medical College and Hospital, Vellore, Tamilnadu, India.

Objective: To identify primary tumour-related factors at transurethral resection of bladder tumour (TURBT) that may predict positive distal ureteric margins (PUM) at the time of radical cystectomy (RC).

Patients And Methods: A retrospective, cohort study was conducted using our institution's data from June 2007 to June 2016. Patients who underwent TURBT followed by RC for non-metastatic urothelial carcinoma (UC) of the bladder were identified. Read More

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December 2018

Cancer overturned: Endometrioma mimicking granulosa cell tumor and the importance of FOXL2 analysis.

Gynecol Oncol Rep 2019 Feb 22;27:8-10. Epub 2018 Nov 22.

Department of Obstetrics and Gynecology, Division of Gynecology and Gynecologic Subspecialties, University of Wisconsin Hospital and Clinics, Madison, WI, United States.

Background: Various ovarian neoplasms may show histological findings that are morphologically indistinguishable from adult granulosa cell tumor (AGCT).

Case Presentation: A 36 year-old women presented with left lower extremity pain and numbness. Ultrasound revealed a 10 cm left adnexal mass treated with ovarian cystectomy. Read More

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February 2019

A retrospective study of surgical treatment and outcome among women with adnexal torsion in eastern Taiwan from 2010 to 2015.

PeerJ 2018 4;6:e5995. Epub 2018 Dec 4.

Department of Obstetrics and Gynecology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan, Taiwan.

Background: Adnexal torsion is a gynecologic emergency that requires surgical treatment. In this study, we reviewed the surgical outcomes of women with adnexal torsion in eastern Taiwan (Hualien county, area 4,629 km, 330,000 residents).

Methods: This retrospective study included 42 women diagnosed with surgically-proven adnexal torsion from January 1, 2010, to September 31, 2015. Read More

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December 2018

A clinically functioning gonadotroph adenoma presenting with abdominal pain, ovarian hyperstimulation and fibromatosis.

Endocrinol Diabetes Metab Case Rep 2018 Dec 11;2018. Epub 2018 Dec 11.

Southmead Hospital, North Bristol NHS Trust, Westbury-on-Trym, Bristol, UK.

Pituitary adenomas can be classified as functioning or non-functioning adenomas. Approximately 64% of clinically non-functioning pituitary adenomas are found to be gonadotroph adenomas on immunohistochemistry. There are reported cases of gonadotroph adenomas causing clinical symptoms, but this is unusual. Read More

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December 2018

Long-term urinary tract effect of ileal conduit after radical cystectomy compared with bladder preservation: a nationwide, population-based cohort study with propensity score-matching analysis.

BMJ Open 2018 Dec 9;8(12):e023136. Epub 2018 Dec 9.

Department of Urology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Objective: Ileal conduit urinary diversion (ICUD) is the most common procedure after radical cystectomy. Although complications have been reported, few patients with ICUD and bladder preservation controls have been available for long-term follow-up. This study compared the long-term effect of structural changes after cystectomy with ICUD to that in bladder preservation controls. Read More

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December 2018

Is neoadjuvant chemotherapy for pT2 bladder cancer associated with a survival benefit in a population-based analysis?

Cancer Epidemiol 2018 Dec 5;58:83-88. Epub 2018 Dec 5.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada; Division of Urology, University of Montreal Hospital Center (CHUM), Montreal, Quebec, Canada.

Background: Patients with organ confined muscle-invasive bladder cancer (MIBC) who are candidates for radical cystectomy (RC) should receive neoadjuvant chemotherapy (CHT). However, the most contemporary CHT use rates indicate low adherence to these guidelines. We tested contemporary neoadjuvant CHT rates and associated cancer-specific mortality (CSM) and overall mortality (OM) in pT2N0 MIBC patients treated with RC. Read More

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December 2018

More Extensive Lymph Node Dissection Improves Survival Benefit of Radical Cystectomy in Metastatic Urothelial Carcinoma of the Bladder.

Clin Genitourin Cancer 2018 Nov 17. Epub 2018 Nov 17.

Cancer Prognostics and Health Outcomes Unit, University of Montreal Health Center, Montreal, Quebec, Canada.

Background: Radical cystectomy (RC) may occasionally be performed in individuals with metastatic urothelial carcinoma of the bladder (mUCB). However, the role of lymph node dissection (LND) for such cases is unknown. Thus, we tested the effect of RC on cancer-specific mortality (CSM) and overall mortality in mUCB patients and the effect of LND and its extent on CSM. Read More

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November 2018

Role of Post-Acute Care on Hospital Readmission After High-Risk Surgery.

J Surg Res 2019 Feb 6;234:116-122. Epub 2018 Oct 6.

Department of Urology, University of Pittsburgh, Pittsburgh, Pennsylvania.

Background: Payment models, including the Hospital Readmissions Reduction Program and bundled payments, place pressures on hospitals to limit readmissions. Against this backdrop, we sought to investigate the association of post-acute care after major surgery and readmission rates.

Methods: We identified patients undergoing high-risk surgery (abdominal aortic aneurysm repair, coronary bypass grafting, aortic valve replacement, carotid endarterectomy, esophagectomy, pancreatectomy, lung resection, and cystectomy) from 2005 to 2010 using the Healthcare Cost and Utilization Project's State Inpatient Database. Read More

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February 2019

The oncological outcomes of small cell carcinoma of the bladder.

Can Urol Assoc J 2018 Dec 3. Epub 2018 Dec 3.

Department of Surgery, Division of Urology, University of Western Ontario, London, ON, Canada.

Introduction: Small cell carcinoma of the bladder (SmCC) is a rare and aggressive genitourinary malignancy. The paucity of clinical trials and outcome data provide no standard treatment guidelines. Accordingly, patient prognosis is poor. Read More

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December 2018

[Fornix reconstruction with conjunctival inclusion cyst marsupialization in severe symblepharon].

Authors:
J L Li Y F Hang

Zhonghua Yan Ke Za Zhi 2018 Dec;54(12):897-901

The General Hospital of Chinese PLA, Medical School of Chinese PLA, Beijing 100853, China.

To report the efficacy of fornix reconstruction with conjunctival inclusion cyst marsupialization in severe symblepharon. Retrospective cases series study. Four patients (4 eyes) with Conjunctival Inclusion Cyst Marsupialization and severe Symblepharon during June 2016 to June 2018 at the PLA General Hospital were included. Read More

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December 2018

Immunomodulatory response of layered small intestinal submucosa in a rat bladder regeneration model.

J Biomed Mater Res B Appl Biomater 2018 Dec 6. Epub 2018 Dec 6.

Department of Urology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.

Based on the hypothesis that bioscaffold permeability is a major factor in determining the outcome of histologically complete and functional bladder regeneration, we evaluated regeneration processes of four-layer porcine small intestinal submucosa (SIS) construct; and compared results between rat bladders augmented with single-layer SIS bioscaffolds. Sprague-Dawley female rats were subjected to hemi-cystectomy followed by anastomosis of a patch of either single- or four-layer porcine SIS. Permeability was analyzed in situ using magnetic resonance imaging (MRI) at post-operative days 7 and 14. Read More

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December 2018
5 Reads

Impact of neoadjuvant chemotherapy on short-term complications and survival following radical cystectomy.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

Department of Urology, University Hospitals Leuven, Herestraat 49, 3000, Louvain, Belgium.

Objectives: To compare perioperative and short-term postoperative complication rates between patients receiving radical cystectomy (RC) after neoadjuvant chemotherapy (NAC) and patients undergoing RC alone. Secondary objectives were to compare overall survival (OS) and cancer-specific survival (CSS).

Materials And Methods: Clinico-pathological data of all patients who received RC between 1996 and 2015 were retrospectively collected. Read More

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December 2018
1 Read

Factors influencing intraoperative conversion from planned orthotopic to non-orthotopic urinary diversion during radical cystectomy.

World J Urol 2018 Dec 5. Epub 2018 Dec 5.

USC Institute of Urology, Keck Medicine of USC, University of Southern California, Los Angeles, CA, USA.

Objectives: To determine and investigate the intraoperative factors that contribute to a change in plan from continent orthotopic neobladder to ileal conduit or continent cutaneous diversion at the time of radical cystectomy.

Subjects And Methods: A retrospective review of our prospectively maintained bladder cancer database was performed. Of the 711 patients who underwent radical cystectomy from 2012 to 2016, 387 (54. Read More

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December 2018
3 Reads

Risk factors related to the recurrence of endometrioma in patients with long-term postoperative medical therapy.

Ginekol Pol 2018 ;89(11):611-617

Department of Obstetrics and Gynecology, Pusan National University School of Medicine Biomedical Research Institute, Pusan National University Hospital, Busan, Korea.

Objectives: The purpose of this study was to identify clinical risk factors for the recurrence of ovarian endometrioma after ovarian cystectomy in Korean women with long-term postoperative medical therapy.

Material And Methods: A total of 134 patients who were surgically treated for endometriotic cysts at Pusan National University Hospital were included in this retrospective study. All patients received long-term postoperative medical treatment for at least 12 months after the first-line conservative surgery. Read More

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January 2018
1 Read

Molecular biomarkers in bladder preservation therapy for muscle-invasive bladder cancer.

Lancet Oncol 2018 Dec;19(12):e683-e695

Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA. Electronic address:

Although muscle-invasive bladder cancer is commonly treated with radical cystectomy, a standard alternative is bladder preservation therapy, consisting of maximum transurethral bladder tumour resection followed by radiotherapy with concurrent chemotherapy. Although no successfully completed randomised comparisons are available, the two treatment paradigms seem to have similar long-term outcomes; however, clinicopathologic parameters can be insufficient to provide clear guidance in the selection of one treatment over the other. Recent advances in the molecular understanding of bladder cancer have led to the identification of new predictive biomarkers that ultimately might help guide the tailored selection of therapy on the basis of the intrinsic biology of the tumour. Read More

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December 2018
1 Read

Pretreatment assessment and perioperative nutritional interventions for patients with bladder cancer undergoing radical cystectomy.

Transl Androl Urol 2018 Dec;7(6):984-986

Department of Urology, Nara Medical University, Kashihara-shi, Nara 634-8522, Japan.

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December 2018
1 Read

Decreasing rates of venous thromboembolism after radical cystectomy: an encouraging trend and more work is still needed.

Transl Androl Urol 2018 Dec;7(6):982-983

1Division of Urology, 2The Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.

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December 2018
6 Reads

Metastatic inflammatory myofibroblastic tumor of the bladder.

Urol Case Rep 2019 Mar 15;23:10-12. Epub 2018 Nov 15.

Department of Surgery - Division of Urology, 1 Hospital Drive, MC 301E, Columbia, MO, 65212, USA.

A 61-year-old male presented with gross hematuria and transurethral resection of bladder tumor revealed inflammatory myofibroblastic tumor (IMT). Due to extent of disease leading to ureteral obstruction and hydronephrosis, radical cystectomy (RC) with ileal conduit urinary diversion was performed. Five months after RC, the patient presented with decreased urine output. Read More

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March 2019
1 Read

Understanding physical activity behavior in patients with bladder cancer before and after radical cystectomy: a qualitative interview study.

Clin Rehabil 2018 Dec 4:269215518815531. Epub 2018 Dec 4.

6 Department of Public Health, University Centre for Nursing and Midwifery, Ghent University, Ghent, Belgium.

Objective:: To explore the determinants of physical activity in patients with bladder cancer before and after radical cystectomy.

Design:: A qualitative research design using semi-structured face-to-face interviews.

Setting And Subjects:: A total of 30 interviews were conducted with people diagnosed with bladder cancer and treated with radical cystectomy at Ghent University Hospital. Read More

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December 2018
1 Read

Robot-assisted resection of gastric duplication cysts in a child: a detailed case report.

Pediatr Med Chir 2018 Dec 4;40(2). Epub 2018 Dec 4.

Department of Pediatric Surgery, "Spirito Santo" Hospital, Pescara; "G. d'Annunzio" University, Chieti-Pescara.

Gastric duplication cysts (GDCs) represent 4-9% of alimentary tract duplications. Early diagnosis and surgical excision are essential to avoid morbidity or neoplastic degeneration. Roboticassisted excision of GDCs has never been described in childhood. Read More

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December 2018
6 Reads

The prognostic role of preoperative circulating neutrophil-lymphocyte ratio in primary bladder cancer patients undergoing radical cystectomy: a meta-analysis.

World J Urol 2018 Dec 3. Epub 2018 Dec 3.

Department of Gynecology, Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang University, Hangzhou, 310009, China.

Background: Systemic inflammatory response (SIR) plays important roles in initiation, promotion and progression of tumor. However, the prognostic role of preoperative circulating neutrophil-lymphocyte ratio (NLR) (known as a marker of SIR) in human primary bladder cancer (BC) undergoing radical cystectomy (RC) remains controversial. Hence, we performed this meta-analysis to better understand the role of preoperative circulating NLR in prognosis prediction for primary BC patients undergoing RC. Read More

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December 2018
2 Reads

A delay ≥8 weeks to neoadjuvant chemotherapy before radical cystectomy increases the risk of upstaging.

Urol Oncol 2018 Nov 30. Epub 2018 Nov 30.

Division of Urology, VA Long Beach Healthcare System, Long Beach, CA; Department of Urology, University of California, Irvine, Orange, CA. Electronic address:

Objectives: To investigate delays to neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) and their effect on outcomes in a large national registry of patients with localized muscle invasive bladder cancer.

Patients And Methods: Within the National Cancer Database (2004-2014), we identified 2,227 patients who underwent NAC and RC for cT2-T4aN0M0 urothelial carcinoma of the bladder. Times from diagnosis to treatments were tested for association with overall survival and pathologic outcomes, using Cox models, and restricted cubic splines regression. Read More

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November 2018
1 Read
2.768 Impact Factor

Robot-assisted Vescica Ileale Padovana: A New Technique for Intracorporeal Bladder Replacement Reproducing Open Surgical Principles.

Eur Urol 2018 Nov 30. Epub 2018 Nov 30.

Department of Urology, University of Verona, Verona, Italy.

Background: The Vescica Ileale Padovana (VIP) was first described in 1989 as a technique for total bladder replacement, and gained popularity due to technical simplicity and functional advantages.

Objective: To report preliminary results and a detailed step-by-step surgical technique description of robot-assisted VIP (ra-VIP) that replicates the open technique principles.

Design, Setting, And Participants: We report the data of 15 consecutive patients who underwent robot-assisted radical cystectomy (RARC) and totally intracorporeal ra-VIP at our institution from April 2015 to March 2017. Read More

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November 2018
6 Reads

Keratinizing squamous metaplasia of the bladder: Our experience and current approaches.

Urologia 2018 Dec 3:391560318810197. Epub 2018 Dec 3.

2 Pathology Unit, ASST-Rhodense, Milan, Italy.

Introduction:: Bladder mucosa is anatomically covered by urothelial epithelium. The replacement of the urothelium with stratified squamous cells is defined as squamous metaplasia which can be keratinizing or non-keratinizing. Clinically, it is also known as leukoplakia or keratinizing cystitis of the bladder. Read More

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December 2018
1 Read

Examining the relationship between complications and perioperative mortality following radical cystectomy: A population-based analysis.

BJU Int 2018 Nov 30. Epub 2018 Nov 30.

Division of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.

Objective: To examine the incidence of perioperative complications after RC and assess their impact on 90-day postoperative mortality during the index stay and upon readmission.

Material And Methods: A total of 57,553 bladder cancer patients (unweighted cohort: 9,137 patients) treated with RC at 360 hospitals in the United States between 2005 to 2013 within the Premier Healthcare Database were used for analysis. Ninety-day perioperative mortality was the primary outcomes. Read More

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November 2018

Robot-Assisted Surgery for Benign Distal Ureteral Strictures: Step-by-Step Technique Using the SP Surgical System.

BJU Int 2018 Nov 30. Epub 2018 Nov 30.

Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA.

Objectives: To describe the step-by-step techniques for robotic ureteral reimplantation performed by using the Vinci SP surgical system (Intuitive Surgical, Sunnyvale, CA). Different case-scenarios were included with an educational purpose.

Materials And Methods: Three consecutive patients diagnosed with distal benign ureteral strictures were counseled for ureteral reimplantation and accepted to undergo surgery performed by using the da Vinci SP surgical system. Read More

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November 2018
9 Reads

Laparoscopic colorectal resection for a giant colonic diverticulum - video vignette.

Colorectal Dis 2018 Nov 29. Epub 2018 Nov 29.

Surgery department of Hospital da Luz Arrábida, Vila Nova de Gaia.

A giant colonic diverticulum (GCD) is a rare disease with less than 200 cases reported in the literature. By definition, a GCD is larger than 4cm in diameter with close sigmoid colon relationship in more than 90% of the cases. En bloc resection of the diverticulum with anterior sigmoid-rectal segment with primary anastomosis is the best treatment approach. Read More

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November 2018
1 Read

Analysis of the prognostic relevance of sex-steroid hormonal receptor mRNA expression in muscle-invasive urothelial carcinoma of the urinary bladder.

Virchows Arch 2018 Nov 27. Epub 2018 Nov 27.

Department of Urology and Pediatric Urology, University of Ulm, Ulm, Germany.

Muscle-invasive urothelial carcinoma of the urinary bladder (UCB) often recurs following radical cystectomy (RC). An altered expression of sex-steroid hormone receptors has been associated with oncological outcomes of UCB and may represent therapeutic targets. Here the expression of different hormone receptors was measured on mRNA levels in patients treated by RC and associated with outcomes. Read More

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November 2018
3 Reads

Comparative Effectiveness of Bladder-preserving Tri-modality Therapy Versus Radical Cystectomy for Muscle-invasive Bladder Cancer.

Clin Genitourin Cancer 2018 Oct 4. Epub 2018 Oct 4.

Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Electronic address:

Introduction: There are limited randomized data comparing radical cystectomy (RC) with bladder-sparing tri-modality therapy (TMT) in the treatment of muscle-invasive bladder cancer (MIBC). Both strategies are thought to have similar survival outcomes with different morbidity profiles. We compare the effectiveness of TMT and RC using decision-analytic modeling and the endpoint of quality-adjusted life years (QALYs). Read More

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October 2018
1 Read

Assessing trends in urinary diversion after radical cystectomy for bladder cancer in the United States.

Urol Oncol 2018 Nov 25. Epub 2018 Nov 25.

USC Institute of Urology, Los Angeles, CA; University of Southern California, Los Angeles, CA; USC/Norris Comprehensive Cancer Center, Los Angeles, CA. Electronic address:

Objectives: We assessed recent trends in both urinary diversion after radical cystectomy for bladder cancer in the United States and patient- and hospital-related characteristics. We also identified variables associated with undergoing continent diversion.

Materials And Methods: We queried the National Cancer Database and identified 27,170 patients who underwent radical cystectomy with urinary diversion from 2004 to 2013. Read More

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November 2018

Bone Flap Technique With Piezosurgery for Impacted Teeth Extraction and Bone Cysts Removal Without Additional Fixation.

J Craniofac Surg 2018 Nov 22. Epub 2018 Nov 22.

Faculty of Dentistry, Department of Oral and Maxillofacial Surgery, Izmir Katip Celebi University, Izmir, Turkey.

To explore a new surgical approach for impacted teeth extraction and cystectomy using piezosurgery that provides proper bone healing in normal anatomical structure without additional fixation and graft materials.In cases with intact and relatively thicker vestibular compact bone, a bone flap design was used with converging osteotomy lines made with piezosurgery tips which allow proper stabilization after enucleation or extraction.Procedure was performed in 10 patients with 9 to 36 months follow-up resulted in satisfactory healing without any complications. Read More

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November 2018

Postoperative weight loss followed by radical cystectomy predicts poor prognosis in patients with muscle-invasive bladder cancer.

Med Oncol 2018 Nov 26;36(1). Epub 2018 Nov 26.

Department of Urology, Hirosaki University Graduate School of Medicine, 5 Zaifu-chou, Hirosaki, 036-8562, Japan.

We aimed to investigate the impact of postoperative weight loss following radical cystectomy (RC) on patients' prognoses. RC and urinary diversion were performed in 512 consecutive patients with muscle-invasive bladder cancer at our hospitals between May 1996 and July 2018. Demographic clinical information, pre- and postoperative serum albumin, hemoglobin, and weight were evaluated retrospectively at 1 month. Read More

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November 2018
2 Reads
2.058 Impact Factor

Utility of Bladder-Sparing Therapy vs Radical Cystectomy for Muscle-Invasive Bladder Cancer.

JAMA Surg 2018 Nov 21. Epub 2018 Nov 21.

CRUK/MRC Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, United Kingdom.

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November 2018
1 Read

Utility of Bladder-Sparing Therapy vs Radical Cystectomy for Muscle-Invasive Bladder Cancer.

JAMA Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of Radiation Oncology, University of Maryland School of Medicine, Baltimore.

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November 2018

Utility of Bladder-Sparing Therapy vs Radical Cystectomy for Muscle-Invasive Bladder Cancer-Reply.

JAMA Surg 2018 Nov 21. Epub 2018 Nov 21.

Department of Surgery, The University of Texas Medical Branch, Galveston.

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November 2018

Compensatory regrowth of the mouse bladder after partial cystectomy.

PLoS One 2018 26;13(11):e0206436. Epub 2018 Nov 26.

Developmental Biology, Stanley Manne Children's Research Institute, Anne and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States of America.

Cystectomy is the removal of all or part of the urinary bladder. It has been observed that there is significant regrowth of the bladder after partial cystectomy and this has been proposed to be through regeneration of the organ. Regrowth of tissue in mammals has been proposed to involve compensatory mechanisms that share many characteristics of true regeneration, like the growth of specialized structures such as blood vessels or nerves. Read More

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November 2018
2 Reads

TROY expression is associated with pathological stage and poor prognosis in patients treated with radical cystectomy.

Cancer Biomark 2018 Nov 10. Epub 2018 Nov 10.

Department of Urology, School of Medicine, Kitasato University, Sagamihara 2520374, Japan.

Background: New biomarkers may help us provide individualized prognosis and allow risk-stratified clinical decision making about radical treatment.

Objectives: This study aimed to determine the tumor necrosis factor of receptor superfamily 19 (TROY) expression in urothelial carcinoma and its relationship to clinicopathological findings.

Methods: Immunohistochemical staining for TROY was carried out in 136 archival radical cystectomy specimens with immunoreactivity being stratified on a 0-9 scale. Read More

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November 2018
1 Read

Metastatic Small Cell Carcinoma of the Urinary Bladder That Recurred in the Vagina 6 Years after Radical Cystectomy: A Case Report.

Case Rep Urol 2018 24;2018:3069294. Epub 2018 Oct 24.

Department of Urology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan.

Small cell carcinoma (SCC) of the urinary bladder is highly aggressive and portends a poor outcome. Herein, we report a patient with recurrent SCC of the urinary bladder who experienced an unusually long-term disease-free duration after radical cystectomy. The patient was a 60-year-old woman who had undergone transurethral resection followed by radical cystectomy for muscle-invasive bladder cancer (high-grade urothelial carcinoma with adenocarcinomatous differentiation) 6 years prior; the surgical specimen had a negative surgical margin. Read More

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October 2018
7 Reads

30-day readmission after radical cystectomy: Identifying targets for improvement using the phases of surgical care.

Can Urol Assoc J 2018 Nov 20. Epub 2018 Nov 20.

Center for Surgery and Health Economics, Department of Surgery, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States.

Introduction: Postoperative readmissions following radical cystectomy (RC) have gained attention in the past decade. Postoperative and post-discharge complications play a role in readmission rates; however, our ability to predict readmissions remains poor.

Methods: Using the National Surgical Quality Improvement Program database, we identified patients with bladder cancer undergoing RC from 2013-2015. Read More

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November 2018
3 Reads

Factors that Influence Selection of Urinary Diversion among Bladder Cancer Patients in Three Community-Based Integrated Health Care Systems.

Urology 2018 Nov 21. Epub 2018 Nov 21.

Kaiser Permanente Center for Health Research, 3800 N. Interstate Avenue, Portland, OR 97227.

Objectives: To assess the relative contributions of patient and surgeon factors for predicting selection of ileal conduit (IC), neobladder (NB), or continent pouch (CP) urinary diversions (UD) for patients diagnosed with muscle-invasive/high-risk non-muscle invasive bladder cancer. This information is needed to enhance research comparing cancer survivors' outcomes across different surgical treatment options.

Methods: Bladder cancer patients age ≥21 years with cystectomy/UD performed from 1/2010 to 6/2015 in three Kaiser Permanente regions were included. Read More

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November 2018
3 Reads

[Urachal cancer - current concepts of a rare cancer (German version)].

Authors:
H Reis T Szarvas

Pathologe 2018 Nov 23. Epub 2018 Nov 23.

Klinik für Urologie, Universitätsmedizin Essen, Westdeutsches Tumorzentrum Essen, Universität Duisburg-Essen, Essen, Deutschland.

Urachal cancer is a rare but aggressive disease. In addition to the non-glandular tumors, non-cystic urachal adenocarcinomas are nowadays distinguished from the primary cystic variant. (Immunohistochemical) markers are only of minor differential diagnostic value and, therefore, the diagnosis is primarily established in a multidisciplinary approach. Read More

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November 2018
3 Reads

Gynecologic Organ Involvement During Radical Cystectomy for Bladder Cancer: Is It Time to Routinely Spare the Ovaries?

Clin Genitourin Cancer 2018 Oct 29. Epub 2018 Oct 29.

Department of Urology, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine-New York Presbyterian Hospital, New York, NY; Englander Institute for Precision Medicine, Weill Cornell Medicine, New York, NY. Electronic address:

Purpose: To determine a subset of women who could undergo ovary-sparing radical cystectomy (OSRC) for bladder cancer without compromising oncologic safety.

Patients And Methods: A retrospective review was performed of 164 consecutive women who underwent cystectomy at a single tertiary-care center from 1997 to 2018. Clinicopathologic and preoperative radiographic data were reviewed. Read More

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October 2018
1 Read

Association between precystectomy epithelial tumor marker response to neoadjuvant chemotherapy and oncological outcomes in urothelial bladder cancer.

Urol Oncol 2019 Jan 20;37(1):1-11. Epub 2018 Nov 20.

Norris Comprehensive Cancer Center, USC Institute of Urology, Los Angeles, CA. Electronic address:

Introduction And Objectives: We previously reported that elevated precystectomy serum levels of epithelial tumor markers predict worse oncological outcome in patients with invasive bladder cancer (BC). Herein, we evaluated the effect of neoadjuvant chemotherapy (NAC) on elevated tumor marker levels and their association with oncological outcomes.

Methods: Under IRB approval, serum levels of Carbohydrate Antigen 125 (CA-125), Carbohydrate Antigen 19-9 (CA 19-9) and Carcinoembryonic Antigen (CEA) were prospectively measured in 480 patients with invasive BC from August 2011 through December 2016. Read More

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January 2019
3 Reads

Safety and fertility outcomes after the conservative treatment of endometrioid borderline ovarian tumours.

BMC Cancer 2018 Nov 23;18(1):1160. Epub 2018 Nov 23.

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, 100730, People's Republic of China.

Background: Because of the rarity of endometrioid borderline ovarian tumours (EBOTs), there is a paucity of data concerning the natural history and prognosis of this condition. Thus, the objective of our study was to establish the feasibility of fertility preservation in young women with EBOTs, as well as their oncological and reproductive outcomes.

Methods: Consecutive patients with EBOTs, treated at a tertiary referral centre during a span of 22 years, were retrospectively analysed. Read More

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November 2018

Laparoscopic radical cystectomy with extracorporeal neobladder: our initial experience.

Urology 2018 Nov 20. Epub 2018 Nov 20.

Department of Urology, Peking University First Hospital. Institute of Urology, Peking University. National Urological Cancer Center, Beijing, China.

Objectives: To illustrate our technique to construct the Institute of Urology Peking University (IUPU) orthotopic ileal bladder and present our initial experience.

Methods: From August 2017 to April 2018, twelve patients with bladder cancer underwent radical cystectomy (RC), pelvic lymph node dissection (LND) and extracorporeal construction of an IUPU neobladder (IUPUB) by an experienced surgeon. We present the demographic, clinicopathologic, perioperative and follow-up data. Read More

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November 2018
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