7,549 results match your criteria Cylindroma


The prognostic value of CXCR4, α-SMA and WASL in upper lip basal cell carcinomas.

Rom J Morphol Embryol 2018 ;59(3):839-849

Department of Dental Materials, Faculty of Dentistry, University of Medicine and Pharmacy of Craiova, Romania;

Lip cancers account for 10-12% of the total head and neck cancers and, although squamous cell carcinoma is by far the most common lower lip cancer, the basal cell carcinoma (BCC) seems to be more common for the upper lip. Most BCCs have a clinically indolent behavior, but there are also local aggressive and∕or metastatic cases, with the incidence of such cases being estimated at about 1-10% of all cases of BCC. Many of the molecular mechanisms underlying this aggression are still unknown, which is why our study aimed to investigate the potential prognosis of a few markers, such as C-X-C chemokine receptor type 4 (CXCR4), alpha-smooth muscle actin (α-SMA) and Wiskott-Aldrich syndrome like (WASL) in upper lip BCCs. Read More

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January 2018

UM-HACC-2A: MYB-NFIB fusion-positive human adenoid cystic carcinoma cell line.

Oral Oncol 2018 Dec 18;87:21-28. Epub 2018 Oct 18.

Department of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, MI 48109, USA; Department of Biomedical Engineering, University of Michigan College of Engineering, Ann Arbor, MI, USA; Department of Otolaryngology, University of Michigan School of Medicine, Ann Arbor, MI, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI, USA. Electronic address:

Objectives: Limited availability of validated human adenoid cystic carcinoma (ACC) cell lines has hindered the mechanistic understanding of the pathobiology of this malignancy and the development of effective therapies. The purpose of this work was to generate and characterize a human ACC cell line.

Material And Methods: Immediately after surgery, a tumor fragment from a minor salivary gland from the tongue of a female Caucasian was minced, dissociated, and a single cell suspension was plated in fibronectin-coated flasks. Read More

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December 2018

Human papillomavirus-related multiphenotypic sinonasal carcinoma: An emerging tumor type with a unique microscopic appearance and a paradoxical clinical behaviour.

Oral Oncol 2018 Dec 16;87:17-20. Epub 2018 Oct 16.

Icahn School of Medicine at Mount Sinai Hospital, New York, NY, USA. Electronic address:

Human papillomavirus (HPV) is well established as a causative factor in most squamous cell carcinomas of the oropharynx (OPSCC). Indeed, a growing awareness over the past two decades that HPV-OPSCC is a distinct form of head and neck cancer has had a profound impact on diagnostic and clinical practices. The sinonasal tract is a second anatomic "hot spot" for HPV-related head and neck carcinomas, but certain pathologic features and the clinical behavior of HPV-related carcinomas at this site remain unclear. Read More

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December 2018

Clinical, pathological and treatment factors associated with the survival of patients with primary pulmonary salivary gland-type tumors.

Lung Cancer 2018 Dec 10;126:174-181. Epub 2018 Nov 10.

Department of Medical Oncology, Changzheng Hospital, Naval Medical University, Shanghai, 200072, China. Electronic address:

Introduction: Primary pulmonary salivary gland-type tumors (p-SGTs) are rare, with poorly understood clinicopathological characteristics and survival. There are only few case reports or small case series, and factors associated with survival need to be identified.

Methods: A population cohort study was conducted using data from patients with histologically diagnosed primary p-SGTs in the Surveillance, Epidemiology and End Results (SEER) database between 1988 and 2013. Read More

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December 2018

Intensity Modulated Radiotherapy (IMRT) + Carbon Ion Boost for Adenoid Cystic Carcinoma of the Minor Salivary Glands in the Oral Cavity.

Cancers (Basel) 2018 Dec 4;10(12). Epub 2018 Dec 4.

Department of Radiation Oncology, Heidelberg University Hospital, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

Background: Adenoid cystic carcinoma (ACC) are more common in the minor salivary glands (MiSGs) than the major salivary glands, and are characterized by slow tumor progression and frequently local recurrence. The main treatment option is surgery followed by combined radiotherapy.

Methods: A retrospective analysis contained 67 patients with ACC of MiSGs in the oral cavity who underwent surgery followed by radiotherapy. Read More

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December 2018
2 Reads

Predictors of nodal metastasis and prognostic significance of lymph node ratio and total lymph node count in tracheobronchial adenoid cystic carcinoma.

Cancer Manag Res 2018 19;10:5919-5925. Epub 2018 Nov 19.

Department of Thoracic Surgery, Affiliated Hospital of Qingdao University, Qingdao, People's Republic of China,

Purpose: To identify potential risk factors of lymph node metastasis and to verify the prognostic significance of the lymph node ratio (LNR) and the total number of lymph nodes examined (NNE) in tracheobronchial adenoid cystic carcinoma (ACC) patients, using a large population-based database.

Patients And Methods: From Surveillance, Epidemiology, and End Results database, we identified 263 patients with tracheobronchial ACC in whom complete lymph node data could be obtained. Logistic regression analysis was performed to determine predictive factors of nodal metastasis. Read More

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November 2018

SOX10 Immunoexpression in Basaloid Squamous Cell Carcinomas: A Diagnostic Pitfall for Ruling out Salivary Differentiation.

Head Neck Pathol 2018 Nov 29. Epub 2018 Nov 29.

Department of Pathology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

SOX10 immunoexpression is increasingly recognized in salivary gland tumors, including but not limited to those with myoepithelial, serous acinar, and intercalated duct differentiation. However, SOX10 expression has not been extensively evaluated in other epithelial tumors that can mimic salivary origin. Basaloid squamous cell carcinoma (SCC) is a unique variant of SCC that shows morphologic overlap with several salivary tumors, including adenoid cystic carcinoma, basal cell adenocarcinoma, and myoepithelial carcinoma. Read More

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November 2018

Cyto-Histopathological Correlation of Skin Adnexal Tumors: A Short Series.

J Cytol 2018 Oct-Dec;35(4):204-207

Department of Pathology, ESI Hospital, New Delhi, India.

Background: Skin adnexal neoplasms are relatively rare and thus uncommonly encountered in routine pathology practice.

Aims: The present study was conducted with the aim to diagnose various skin adnexal tumors on fine-needle aspiration cytology (FNAC) followed by confirmation on histopathology and immunohistochemistry of the excised tumor.

Materials And Methods: A total of 11 cases of superficial nodular swellings of the skin were studied over a period of 2 years from 2015 to 2016. Read More

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December 2018

Malignant Sweat Gland Tumors.

Hematol Oncol Clin North Am 2019 Feb;33(1):53-71

Department of Pathology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA. Electronic address:

Malignant sweat gland neoplasms are a confusing area within dermatopathology, with many entities reported under several designations in the literature. This review describes the key clinical and histopathologic features of select malignant adnexal neoplasms, including porocarcinoma, papillary carcinoma, adenoid cystic carcinoma, cribriform carcinoma, apocrine hidradenocarcinoma, malignant mixed tumor of the skin, syringoid carcinoma, cylindrocarcinoma, spiradenocarcinoma, mucinous carcinoma, polymorphous sweat gland carcinoma, microcystic adnexal carcinoma, secretory carcinoma of the skin, and primary cutaneous signet ring cell carcinoma. For entities with overlapping features, differential diagnoses are discussed. Read More

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February 2019

Oropharyngeal adenoid cystic carcinoma invading the mandibular bone through the mandibular foramen.

Oral Radiol 2018 Nov 15. Epub 2018 Nov 15.

Department of Oral and Maxillofacial Radiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Adenoid cystic carcinoma (ACC) is a rare epithelial tumor of the head and neck region, and one of the most common malignant tumors of the salivary glands. ACC is a slow-growing tumor characterized by perineural invasion and often has a high-recurrence rate. We describe a case of oropharyngeal ACC invading the mandibular bone through the mandibular foramen that showed a rare pattern of origin and invasion. Read More

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November 2018

A case of sublingual adenoid cystic carcinoma involving the mandible presenting as a "skip lesion".

Oral Radiol 2018 Sep 27;34(3):281-287. Epub 2017 Nov 27.

Dental Comprehensive Diagnosis Room, Okayama University Hospital, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.

Adenoid cystic carcinoma (ACC) is a slowly growing malignant neoplasm with a propensity for perineural invasion. Microscopic invasion of ACC often prevents its detection on computed tomography (CT) or magnetic resonance imaging (MRI). We herein report a rare case of sublingual ACC presenting as a "skip lesion" that rapidly infiltrated the mandible after tumor resection. Read More

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September 2018
3 Reads

Adenoid Cystic Carcinoma With Sialolithiasis of the Left Submandibular Gland: A Case Report and Literature Review.

Int J Surg Pathol 2018 Nov 27:1066896918814304. Epub 2018 Nov 27.

1 Aichi Gakuin University, Nagoya, Japan.

Adenoid cystic carcinoma is one of the most common salivary gland malignancies with poor long-term prognosis, but the coexistence of sialoliths is extraordinarily rare. In this article, we report a case of 30-year-old woman with a history of submandibular area swelling with intermittent pain increasing during mealtimes that had led her attending physician to diagnose a sialolith in the left submandibular gland on a radiograph 10 years before. However, the surgical specimen proved to be an adenoid cystic carcinoma accompanied with a sialolith. Read More

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November 2018
1 Read

Comparison of p63/p40 Expression With Myoepithelial Markers in Minor Salivary Gland Tumors.

Int J Surg Pathol 2018 Nov 27:1066896918813678. Epub 2018 Nov 27.

1 São Leopoldo Mandic Institute and Research Center, Campinas, São Paulo, Brazil.

The present study aimed to compare the expression of p63/p40 with smooth muscle actin (SMA) and vimentin (VIM) by myoepithelial cells in minor salivary gland tumors. Fifty-two formalin-fixed paraffin-embedded samples of minor salivary gland tumors derived from intercalated duct (pleomorphic adenoma [PA], adenoid cystic carcinoma [ACC], epithelial-myoepithelial carcinoma [EMC], polymorphous adenocarcinoma [PAC], and secretory carcinoma [SC]) and 3 samples of minor salivary gland tumors derived from excretory duct (mucoepidermoid carcinoma [MEC]) were evaluated by means of immunohistochemistry. The data were analyzed qualitatively. Read More

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November 2018

[The clinicopathological features and curative effect of the bronchoscopic interventional therapy combined with radiotherapy for the treatment of locally recurrent lung adenoid cystic carcinoma].

Zhonghua Zhong Liu Za Zhi 2018 Nov;40(11):864-868

Department of Oncology, Shanghai Pudong New Area People's Hospital, Pudong New Area, Shanghai 201299, China.

To explore the clinical value of endoscopic interventional therapy for locally recurrent primary lung adenoid cystic carcinoma (ACC). The clinical data of 42 patients with locally recurrent ACC were retrospectively analyzed, and the differences of tracheal and bronchial diameter, airway scoring grade and airway obstruction degree before and after treatment were compared among three treatment methods: bronchoscopic interventional therapy + palliative radiotherapy, interventional therapy alone, and non-interventional therapy. Log rank test and Cox proportional risk model multi-factor analysis were used to determine the prognostic factors of ACC patients with local recurrence, and the long-term effect of bronchoscopic interventional therapy on ACC with local recurrence was determined. Read More

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November 2018
3 Reads

Metastasis of adenoid cystic carcinoma from a submandibular gland to the larynx.

Auris Nasus Larynx 2018 Nov 22. Epub 2018 Nov 22.

Department of Otorhinolaryngology, Head & Neck Surgery, National Sencai Medical Center, Japan.

The present article discusses the first reported case of adenoid cystic carcinoma (ACC) metastasis from a submandibular gland to the larynx. Both treatments of distant metastasis of ACC and secondary laryngeal tumor are challenging. Despite its slow progression, ACC is associated with high rates of local recurrence, distant metastasis, and poor prognosis. Read More

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November 2018
4 Reads

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.

Head Neck Pathol 2018 Nov 22. Epub 2018 Nov 22.

Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.

Head and neck pathology present a unique set of challenges including the morphological diversity of the neoplasms and presentation of metastases of unknown primary origin. The detection of human papillomavirus and Epstein-Barr virus associated with squamous cell carcinoma and newer entities like HPV-related carcinoma with adenoid cystic like features have critical prognostic and management implications. In salivary gland neoplasms, differential diagnoses can be broad and include non-neoplastic conditions as well as benign and malignant neoplasms. Read More

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November 2018
3 Reads

Dosimetric advantages of stereotactic radiosurgery as a boost to adjuvant conventional radiotherapy in the setting of adenoid cystic carcinoma of the parotid with skull base invasion.

Clin Case Rep 2018 Nov 23;6(11):2126-2130. Epub 2018 Sep 23.

Department of Radiation Oncology MD Anderson Cancer Center Houston Texas.

This study highlights gamma knife stereotactic radiosurgery (GK-SRS) as boost therapy in a patient with adenoid cystic carcinoma of the parotid involving the skull base and invasion of the facial nerve. Using GK-SRS, dose to the brainstem and temporal lobe were reduced when compared to less conformal radiotherapy techniques. Read More

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November 2018
4 Reads

Giant Mushroom-Like Cutaneous Cylindroma of the Head.

Open Access Maced J Med Sci 2018 Oct 25;6(10):1868-1870. Epub 2018 Sep 25.

Städtisches Klinikum Dresden, Academic Teaching Hospital of the Technical University, Institute of Pathology "Georg Schmorl", Dresden, Germany.

Background: Dermal cylindroma is a rare benign skin tumour.

Case Report: We report a giant stalked, mush-room-like cylindroma of the head-and-neck region in a 73-year-old female patient. A tumour was surgically removed, and the defect could be closed by a cheek transposition flap. Read More

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October 2018
1 Read

Transfection of T-Box Transcription Factor and Synergistically Promote Self-Renewal and Invasive Phenotype in Oral Cancer Cells.

Int J Mol Sci 2018 Nov 16;19(11). Epub 2018 Nov 16.

Department of Maxillofacial Diagnostic and Surgical Science, Field of Oral and Maxillofacial Rehabilitation, Graduate school of Medical and Dental Sciences, Kagoshima University, Kagoshima 890-8544, Japan.

Recent studies suggest that epithelial⁻mesenchymal transition (EMT) correlates with cancer metastasis. In addition, there is growing evidence of the association of EMT with cancer stem cells (CSCs). Recently, we showed that the T-box transcription factor could be a strong regulator of EMT and the CSC phenotype, which were effectively suppressed by a knockdown in an adenoid cystic carcinoma cell line. Read More

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November 2018
3 Reads

Endoscopic endonasal resection of adenoid cystic carcinoma of the sinonasal tract and skull base.

Laryngoscope 2018 Nov 19. Epub 2018 Nov 19.

Department of Biotechnology and Life Sciences, Varese, Italy.

Objectives: Adenoid cystic carcinoma (ACC) is a locally aggressive salivary gland malignancy prone to perineural invasion and local recurrences. In the literature, few data exist to guide treatment when this tumor involves the paranasal sinuses and skull base. We report our experience in the management of sinonasal adenoid cystic carcinoma through an endoscopic endonasal approach. Read More

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November 2018
3 Reads

Premalignant and Malignant Mucosal lesions: Clinical and Pathological Findings Part II. Premalignant and malignant mucosal lesions.

J Am Acad Dermatol 2018 Nov 14. Epub 2018 Nov 14.

Department of Dermatology, Boston University School of Medicine, Boston, MA. Electronic address:

Part 2 of this 2-part continuing medical education series discusses the clinical and histopathologic features of common premalignant and malignant lesions of the oral cavity. It is imperative for dermatologists to be able to recognize suspicious lesions, determine biopsy need, counsel, and refer patients presenting with premalignant or malignant conditions appropriately. Given the higher rates of mortality and morbidity of oral mucosal malignancies due to late diagnosis, appropriate treatment with multidisciplinary care in a timely manner is essential to these neoplasms. Read More

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November 2018
3 Reads

Prognostic factors and survival in adenoid cystic carcinoma of the sinonasal cavity.

Head Neck 2018 Nov 17. Epub 2018 Nov 17.

Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.

Background: Optimal treatment and prognostic factors affecting long-term survival in patients with sinonasal adenoid cystic carcinoma (ACC) have yet to be clearly defined.

Methods: We conducted a retrospective review of patients treated with curative intent from 1980-2015 at MD Anderson Cancer Center.

Results: One hundred sixty patients met inclusion criteria, including 8 who were treated with radiotherapy alone. Read More

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November 2018
3 Reads

Molecular methods for detection of prognostic and predictive markers in diagnosis of adenoid cystic carcinoma of the salivary gland origin.

Cesk Patol 2018 ;54(3):132-136

Adenoid cystic carcinoma of salivary gland origin (AdCC) is second most common salivary carcinoma characterized by frequent recurrences, perineural invasion and high long-term mortality rate. The surgical resection of the tumor in combination with adjuvant radiotherapy is the only method of choice. AdCC has been studied, altogether with immunohistochemistry, by numerous molecular-genetic techniques. Read More

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January 2018
4 Reads

[Management of a tracheal adenoid cystic medico-surgical carcinoma].

Rev Mal Respir 2018 Nov 12. Epub 2018 Nov 12.

Service d'oncologie thoracique, maladie de la plèvre et pneumologie interventionnelle, hôpital Nord, chemin des Bourrely, 13015 Marseille, France. Electronic address:

Adenoid cystic carcinoma or cylindroma is a rare tumor of the trachea which arises from mucous secreting cells. Its evolution and growth are slow but it is often fatal in the absence of radical treatment. The latter relies on a surgical sleeve resection of the pathological area, with a tracheo-tracheal anastomosis. Read More

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November 2018

Overexpression Cathepsin D Contributes to Perineural Invasion of Salivary Adenoid Cystic Carcinoma.

Front Oncol 2018 31;8:492. Epub 2018 Oct 31.

State Key Laboratory of Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Cathepsin D (CTSD) is a pivotal orchestrator in the occurrence and development of tumors. Recently, CTSD was detected in salivary adenoid cystic carcinoma (SACC). However, its functional role in perineural invasion (PNI) of SACC remained elusive. Read More

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October 2018

PLAG1, SOX10, and Myb Expression in Benign and Malignant Salivary Gland Neoplasms.

J Pathol Transl Med 2018 Nov 14. Epub 2018 Nov 14.

Department of Pathology, National Cancer Center, Goyang, Korea.

Background: Recent findings in molecular pathology suggest that genetic translocation and/or overexpression of oncoproteins is important in salivary gland tumorigenesis and diagnosis. We investigated PLAG1, SOX10, and Myb protein expression in various salivary gland neoplasm tissues.

Materials And Methods: A total of 113 cases of surgically resected salivary gland neoplasms at the National Cancer Center from January 2007 to March 2017 were identified. Read More

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November 2018
4 Reads

Microfluidic Analyzer Enabling Quantitative Measurements of Specific Intracellular Proteins at the Single-Cell Level.

Micromachines (Basel) 2018 Nov 12;9(11). Epub 2018 Nov 12.

State Key Laboratory of Transducer Technology, Institute of Electronics, Chinese Academy of Sciences, Beijing 100190, China.

This paper presents a microfluidic instrument capable of quantifying single-cell specific intracellular proteins, which are composed of three functioning modules and two software platforms. Under the control of a LabVIEW platform, a pressure module flushed cells stained with fluorescent antibodies through a microfluidic module with fluorescent intensities quantified by a fluorescent module and translated into the numbers of specific intracellular proteins at the single-cell level using a MATLAB platform. Detection ranges and resolutions of the analyzer were characterized as 896. Read More

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November 2018
4 Reads

Primary Lung Tumors in Children: Radiologic-Pathologic Correlation From the Radiologic Pathology Archives.

Radiographics 2018 Nov-Dec;38(7):2151-2172

From the Department of Radiology and Radiological Sciences (J.P.L., E.M.C.) and Department of Pathology (J.P.L., A.R.H., E.M.C.), Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd, Bethesda, MD 20814; Thoracic Radiology Section (J.P.L., D.M.B.) and Pediatric Radiology Section (D.M.B., E.M.C.), American Institute for Radiologic Pathology, Silver Spring, Md; Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pa (D.M.B.); Department of Diagnostic Radiology, Division of Diagnostic Imaging, The University of Texas MD Anderson Cancer Center, Houston, Tex (B.W.C.); and Department of Radiology, Walter Reed National Military Medical Center, Bethesda, Md (M.A.P.).

Primary lung tumors in children are rare, with a narrow range of diagnostic considerations. However, the overlapping imaging appearances of these tumors necessitate attention to key discriminating imaging and pathologic features. In the neonate and infant, the important considerations include pleuropulmonary blastoma (PPB), infantile fibrosarcoma, and fetal lung interstitial tumor. Read More

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November 2018
2 Reads

Programmed death ligand 1 and CD8+ immune cell infiltrates in resected primary tracheal malignant neoplasms.

Eur J Cardiothorac Surg 2018 Nov 12. Epub 2018 Nov 12.

Division of Thoracic Surgery, Massachusetts General Hospital, Boston, MA, USA.

Objectives: Many patients with primary malignant tracheal neoplasms are not surgical candidates nor do they experience residual or recurrent disease after surgery and may benefit from alternative therapies. This study explores the expression of programmed death ligand 1 (PD-L1) in patients with primary tracheal malignancy as a biomarker for candidacy for treatment with immune checkpoint inhibitors.

Methods: We conducted a retrospective review of the medical records of 23 patients with resected primary tracheal malignant tumours from 2010 to 2016. Read More

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November 2018
4 Reads

[Clinical diagnosis and treatment of adenoid cystic carcinoma of the external auditory canal].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Nov;32(21):1660-1664

Department of Otorhinolaryngology,Chengdu Shangjin Nanfu Hospital, Chengdu, 611743,China.

To discuss the clinical diagnosis, therapies and prognosis of adenoid cystic carcinoma of external auditory canal.Eleven patients with adenoid cystic carcinoma of external auditory canal, who had been admitted to West China hospital, Sichuan university from April 2009 to October 2015 were recruited and a retrospective analysis was performed.All the 11 patients were treated with surgery except one elderly with T1 stage who was only treated with radiotherapy(RT),1 of the 10 patients treated with surgery were added on radiotherapy after surgery. Read More

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November 2018
1 Read

Expression of EpCAM in adenoid cystic carcinoma.

Pathology 2018 Dec 30;50(7):737-741. Epub 2018 Oct 30.

Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea. Electronic address:

The mutational landscape of adenoid cystic carcinoma (ACC) is currently being revealed, but further studies are needed to identify biomarkers as therapeutic targets or prognostic factors of ACC. In this study, we investigated the expression of epithelial cell adhesion molecule (EpCAM) in ACCs. We retrospectively collected 83 cases of surgically resected ACCs. Read More

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December 2018

Advanced adenoid cystic carcinoma (ACC) is featured by SWI/SNF chromatin remodeling complex aberrations.

J Cancer Res Clin Oncol 2018 Oct 31. Epub 2018 Oct 31.

Department of Molecular and Translational Oncology, Marie Sklodowska-Curie Memorial Cancer Center, Institute of Oncology, Warsaw, Poland.

Purpose: Adenoid cystic carcinoma (ACC) is a rare neurotropic cancer with slow progression occurring in salivary glands and less frequently in other body parts. ACC is featured by hyperchromatic nuclei and various mutations in genes encoding chromatin-related machineries. The ACC treatment is mainly limited to the radical surgery and radiotherapy while the chemotherapy remains ineffective. Read More

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October 2018
1 Read

Spinal Metastases from Adenoid Cystic Carcinoma of the Parotid Gland.

Chin Med J (Engl) 2018 Nov;131(21):2616-2617

Department of Orthopaedic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.

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November 2018
2 Reads

NKX2.2 immunohistochemistry in the distinction of Ewing sarcoma from cytomorphologic mimics: Diagnostic utility and pitfalls.

Cancer Cytopathol 2018 Nov 30;126(11):942-949. Epub 2018 Oct 30.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA.

Background: Ewing sarcoma (ES) is a round cell sarcoma that can be challenging to diagnose on cytologic material given its significant overlap with numerous mesenchymal, epithelial, and lymphoid cytomorphologic mimics. The objective of this study was to assess the utility of a novel marker, NKX2.2, in the diagnosis of ES in cytologic material and its ability to distinguish ES from its mimics. Read More

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November 2018
3 Reads

Diagnostic Accuracy of Fine Needle Aspiration Cytology in Lesions of Oral Cavity and Salivary Glands: A Clinico-Pathological Study.

Open Dent J 2018 28;12:782-790. Epub 2018 Sep 28.

Department of Pathology, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.

Objective: Fine Needle Aspiration Cytology (FNAC) is a rapid, reliable and safe diagnostic tool used for various lesions of the oral cavity and salivary glands. The present study was undertaken to categorize the cytomorphology of the oral cavity and salivary gland lesions on FNAC and to assess the accuracy of FNAC in arriving at a diagnosis.

Materials And Methods: A prospective study on oral cavity swellings and salivary gland aspirates was done during a 2 year period from August 2015 to July 2017 in which a total of 70 FNAC's were performed. Read More

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September 2018
10 Reads

Emergency Tracheal Surgery for Adenoid Cystic Carcinoma: A Rare Entity.

J Coll Physicians Surg Pak 2018 Nov;28(11):882-884

Department of Thoracic Surgery, Combined Military Hospital, Lahore, Pakistan.

Primary tumours of the trachea are rare. Adenoid cystic carcinoma (ACC) constitutes less than 1% of these tumours. They occasionally masquerade as asthma. Read More

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November 2018
4 Reads

Abnormal activation of the Akt signaling pathway in adenoid cystic carcinoma.

Eur Arch Otorhinolaryngol 2018 Dec 26;275(12):3039-3047. Epub 2018 Oct 26.

Cell Culture Laboratory, School of Dentistry, Federal University of Pará (UFPA), Belém, PA, Brazil.

Purpose: Adenoid cystic carcinoma (ACC) is an intriguing lesion because it shows a slow growth in the beginning, but a late poor prognosis due to perineural invasion, metastasis and recurrence. This study aimed to investigate whether Akt signaling would be deregulated in adenoid cystic carcinoma and its consequence in the expression of associated proteins.

Methods: The expression of the Akt, p-Akt, NFκB, β-catenin, cyclin D1 and COX-2 was assessed by immunohistochemistry in 10 cases of ACC, 17 cases of pleomorphic adenoma (PA), and 7 cases of normal salivary gland (NSG). Read More

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December 2018
5 Reads

Expression of matrix metalloproteinases (MMPs-2, -7, -9, and -26) and tissue inhibitors of metalloproteinases (TIMPs-1 and -2) in pleomorphic adenomas and adenoid cystic carcinomas.

Eur Arch Otorhinolaryngol 2018 Dec 25;275(12):3075-3082. Epub 2018 Oct 25.

Oral Pathology Post-Graduation Program, Federal University of Rio Grande do Norte, Av. Senador Salgado Filho, 1787, Lagoa Nova, Natal, Rio Grande Do Norte, 59056-000, Brazil.

Purpose: To compare the immunohistochemical expression of matrix metalloproteinases-2, -7, -9 and -26 and tissue inhibitors of metalloproteinases-1 and -2 in pleomorphic adenomas and adenoid cystic carcinomas of the minor salivary glands.

Methods: Twenty cases of pleomorphic adenomas and 20 cases of adenoid cystic carcinomas were evaluated for the immunohistochemical expression of matrix metalloproteinases-2, -7, -9, and -26 and tissue inhibitors-1 and -2 in tumor parenchyma.

Results: Most pleomorphic adenomas and adenoid cystic carcinomas showed high expression of matrix metalloproteinases and tissue inhibitors, predominantly located in the tumor cells. Read More

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December 2018
5 Reads

The Biaxial Double-Barrel Fibula Flap-A Simplified Technique for Fibula Maxillary Reconstruction.

J Oral Maxillofac Surg 2018 Sep 27. Epub 2018 Sep 27.

Director, Head and Neck Cancer Program, Legacy Good Samaritan Medical Center, Portland; Consultant, Head and Neck Institute, Portland, OR.

Purpose: Previously described techniques for microvascular fibula reconstruction of Brown Class II to IV maxillectomy defects are complex, require multiple osteotomies, result in a short pedicle, and inadequately reconstruct the dental alveolus in preparation for endosseous implants. This report describes a simplified technique for Brown Class II to IV defects that re-creates facial support, allows for dental reconstruction with appropriately positioned implants, and maintains adequate pedicle length.

Materials And Methods: A retrospective chart review was performed of all patients with Brown Class II to IV maxillectomy defects immediately reconstructed with a biaxial double-barrel fibula flap technique. Read More

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September 2018
1 Read

Accelerated Hypofractionated Active Raster-Scanned Carbon Ion Radiotherapy (CIRT) for Laryngeal Malignancies: Feasibility and Safety.

Cancers (Basel) 2018 Oct 18;10(10). Epub 2018 Oct 18.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany.

(1) Background: The authors present the first results of active raster-scanned carbon ion radiotherapy (CIRT) for radioresistant laryngeal malignancies regarding efficacy and toxicity. (2) Methods: 15 patients with laryngeal adenoid cystic carcinoma (ACC; = 8; 53.3%) or chondrosarcoma (CS; = 7; 46. Read More

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October 2018
4 Reads

Pretreatment quantitative F-FDG PET/CT parameters as a predictor of survival in adenoid cystic carcinoma of the salivary glands.

Clin Imaging 2019 Jan - Feb;53:17-24. Epub 2018 Oct 4.

Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN 55455, USA. Electronic address:

Purpose: The aim of this study was to determine the unique prognostic value of quantitative F-FDG PET/CT parameters to assess progression-free survival (PFS), distant metastasis-free survival (DMFS), and overall survival (OS) in patients with salivary gland adenoid cystic carcinoma (ACC).

Methods: We performed a retrospective study including 23 patients (15 men, 8 women; median age, 58 years; range, 21-91 years) with salivary gland ACC between January 2009 and October 2017 who underwent F-FDG PET/CT scan prior to treatment. Maximum, mean, peak, tumor-to-mediastinal blood pool and tumor-to-liver standardized uptake values (SUV, SUV, SUV, SUV and SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were obtained from F-FDG PET/CT. Read More

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October 2018
1 Read

Expression of α-smooth muscle actin in benign and malignant salivary gland tumors: An immunohistochemical study.

Indian J Pathol Microbiol 2018 Oct-Dec;61(4):479-484

Department of Oral Pathology and Microbiology, Manipal College of Dental Sciences, Manipal Academy of Higher Education, Mangalore, Karnataka, India.

Background And Objectives: Myoepithelial cells (ME) are known to contribute in the patterning of salivary gland neoplasms (SGN) and possess cytoplasmic smooth muscle actin (SMA) revealed by alpha SMA (α-SMA). The present study aimed to assess the expression of α-SMA in selected benign and malignant SGN (pleomorphic adenoma [PA], mucoepidermoid carcinoma (MEC), adenoid cystic carcinoma (ACC), and polymorphous low-grade adenocarcinoma (PLGA).

Materials And Methods: The intensity and pattern of expression of α-SMA were studied in 25 cases of SGN's ACC (n = 7), MEC (n = 8), PA (n = 8), and PLGA (n = 2), and correlated with the histological patterns. Read More

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October 2018
2 Reads

Utility of FDG PET/CT in the Characterization of Sinonasal Neoplasms: Analysis of Standardized Uptake Value Parameters.

AJR Am J Roentgenol 2018 Dec 9;211(6):1354-1360. Epub 2018 Oct 9.

2 Department of Radiology, University of Minnesota Medical Center, Fairview, 420 Delaware St SE, B-226 Mayo Memorial Bldg, MMC 292, Minneapolis, MN 55455.

Objective: We aimed to evaluate the contribution of different standardized uptake value (SUV) parameters generated from pretreatment F-FDG PET/CT in the characterization of sinonasal neoplasms with histopathologic correlations.

Materials And Methods: This retrospective study included 97 consecutive patients (58 men, 39 women; age range, 20-93 years; mean age, 62 years) with pathologically proven untreated sinonasal neoplasms who underwent FDG PET/CT from February 2010 to August 2017. Semiquantitative analysis of primary tumors were performed to evaluate the maximum standardized uptake value (SUV), mean standardized uptake value (SUV), and the ratio of the SUV of the primary tumor to the SUV of mediastinal blood pool, which we refer to here as " SUV. Read More

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December 2018
7 Reads

Evaluation of Glypican-3 expression in benign and malignant salivary gland tumors.

J Oral Biol Craniofac Res 2019 Jan-Mar;9(1):63-66. Epub 2018 Sep 6.

Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Introduction: Glypican-3 (GPC3) is involved in regulation of cell proliferation and morphogenesis. It is abundant in embryonic tissue, but limited in most adult tissues. GPC3 deletion or mutation can disturb the balance between cell apoptosis and proliferation, which may result in tumorigenesis. Read More

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September 2018
1 Read

[Clinical analysis of malignant salivary gland tumors of the larynx].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Sep;53(9):684-687

Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai 200031, China.

To evaluate the clinical features, treatments and prognoses of malignant salivary gland tumors of the larynx. A total of 14 patients with malignant salivary gland tumors of the larynx diagnosed and treated in our hospital between 2003 and 2014 were analyzed retrospectively, and were compared with 62 patients from the Surveillance, Epidemiology, and End (SEER) database of American for survival rates. Results Among 14 patients from our hospital, 9 males and 5 females, with a median of 66. Read More

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September 2018
10 Reads

Role of Noxa in proliferation, apoptosis, and autophagy in human adenoid cystic carcinoma.

J Oral Pathol Med 2018 Oct 5. Epub 2018 Oct 5.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, China.

Background: Noxa, which is subset of the Bcl-2 family of proteins, was previously reported to have considerable therapeutic potential in diverse cancers. However, its expression and role in salivary gland adenoid cystic carcinoma (ACC) have not been well studied. This study aimed to elucidate the expression and role of Noxa in salivary gland ACC. Read More

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October 2018

Adamantinoma-like Ewing Sarcoma of the Salivary Glands: A Newly Recognized Mimicker of Basaloid Salivary Carcinomas.

Am J Surg Pathol 2018 Oct 3. Epub 2018 Oct 3.

Department of Pathology, The Johns Hopkins Hospital, Baltimore, MD.

Adamantinoma-like Ewing sarcoma (ALES) is a rare tumor that demonstrates the EWSR1-FLI1 translocation characteristic of Ewing sarcoma despite overt epithelial differentiation including diffuse expression of cytokeratins and p40. Most cases of ALES described to date have occurred in the head and neck where they can mimic a wide range of small round blue cell tumors. Because distinguishing ALES from basaloid salivary gland carcinomas can be particularly difficult, we analyzed a series of 10 ALESs that occurred in the salivary glands with the aim of identifying features that allow for better recognition of this entity. Read More

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October 2018
2 Reads

Adenoid cystic carcinoma: A study of 19 cases of salivary and extra-salivary tumours diagnosed by fine needle aspiration cytology.

Diagn Cytopathol 2018 Oct 3. Epub 2018 Oct 3.

Department of Pulmonary Medicine, Government Medical College and Hospital, Chandigarh, India.

Background: Adenoid cystic carcinoma (ACC) arises at sites where seromucinous or sweat gland epithelium is present and commonly affects the salivary glands. Rarely it can occur at extra-salivary locations.

Methods: A retrospective analysis of 19 cases of ACC diagnosed on fine needle aspiration cytology (FNAC) over a period of 15 y (2002-2016) was made. Read More

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October 2018
7 Reads

Hydrogen Sulfide and Hydrogen Sulfide-Synthesizing Enzymes Are Altered in a Case of Oral Adenoid Cystic Carcinoma.

Case Rep Oncol 2018 May-Aug;11(2):585-590. Epub 2018 Aug 27.

Department of Pathology, Louisiana State University Health Shreveport, Shreveport, Louisiana, USA.

Adenoid cystic carcinomas (ACC) constitute 1% of all head and neck malignancies and are very rare in the oral cavity. With < 60 oral ACCs described, their pathobiology is incompletely understood. Here, we report a case of oral cavity ACC in a 54-year-old woman. Read More

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August 2018
11 Reads