7,649 results match your criteria Cylindroma


CD73 a novel marker for the diagnosis of benign and malignant salivary gland tumors.

J Clin Exp Dent 2019 Mar 1;11(3):e213-e218. Epub 2019 Mar 1.

Undergraduate Student, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran.

Background: Ecto-5'-nucleotidase (CD73) plays an important role in the development of several types of cancer; however, its prognostic significance in salivary gland tumors remains unknown. The current study was conducted to investigate the expression of CD73 in such tumors.

Material And Methods: In this retrospective study, immunohistochemical expression of CD73 was evaluated in 25 pleomorphic adenomas, 20 mucoepidermoid carcinomas and 20 adenoid cystic carcinomas using the Envision technique. Read More

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http://dx.doi.org/10.4317/jced.54918DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461735PMC

The endocytic pathways of carbon dots in human adenoid cystic carcinoma cells.

Cell Prolif 2019 Apr 17:e12586. Epub 2019 Apr 17.

Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.

Objectives: This study aimed at investigating cellular uptake pathways of carbon dots (CDs) in human adenoid cystic carcinoma cell line ACC-2.

Materials And Methods: We synthesized CDs using a hydrothermal method with citric acid and polyethylenimine (PEI, Mw = 25 000). The CDs incubated with the ACC-2 cells showed their bioimaging capabilities using a confocal microscopy test. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cpr.12586
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http://dx.doi.org/10.1111/cpr.12586DOI Listing
April 2019
1 Read

Diagnostic Significance of HRAS Mutations in Epithelial-Myoepithelial Carcinomas Exhibiting a Broad Histopathologic Spectrum.

Am J Surg Pathol 2019 Apr 15. Epub 2019 Apr 15.

Departments of.

Epithelial-myoepithelial carcinoma (EMC) is a rare salivary gland tumor that is histologically characterized by biphasic tubular structures composed of inner ductal and outer clear myoepithelial cells. Because of its histologic variety, it is sometimes challenging to make an accurate diagnosis, and useful ancillary tests are essential for this purpose. We investigated 87 cases of EMC arising in the major and minor salivary glands and seromucinous glands in the nasal cavity or bronchus to describe the histologic features and mutation status of selected key oncogenes. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001258DOI Listing
April 2019
1 Read

Effects of adjuvant radiation therapy on survival for patients with resected primary tracheal carcinoma: an analysis of the National Cancer Database.

Jpn J Clin Oncol 2019 Apr 12. Epub 2019 Apr 12.

Department of Radiation Oncology, University of Louisville Hospital, Louisville KY, USA.

Objective(s): To identify predictors for receiving adjuvant radiation therapy (RT) and investigate the impact of adjuvant RT on survival for patients with resected primary tracheal carcinoma (PTC).

Methods: The National Cancer database was queried for patients with PTC diagnosed from 2004 to 2014 undergoing resection. Patients who died within 30 days of resection were excluded to minimize immortal time bias. Read More

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http://dx.doi.org/10.1093/jjco/hyz047DOI Listing
April 2019
32 Reads

Metastasis of submandibular gland carcinoma to the toe bone: a case report.

Br J Oral Maxillofac Surg 2019 Apr 8. Epub 2019 Apr 8.

Department of Orthopedics Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, 12 Health Road, Shijiazhuang, Hebei 050011, PR China. Electronic address:

Adenoid cystic carcinoma (ACC) is rare. One of its characteristics is a high rate of distant metastasis, and the most common site is the lungs, followed by the brain and liver. Bony metastases account for up to 1. Read More

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http://dx.doi.org/10.1016/j.bjoms.2019.03.011DOI Listing
April 2019
1 Read

Salivary gland carcinoma in Shanghai (2003-2012): an epidemiological study of incidence, site and pathology.

BMC Cancer 2019 Apr 11;19(1):350. Epub 2019 Apr 11.

Department of Oral & Maxillofacial - Head & Neck Oncology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Stomatology, Shanghai, 200011, China.

Background: Salivary gland carcinoma ranks the sixth in head and neck cancers while it is relatively rare in its incidence. Epidemiological studies have been based mostly on institutional data, leading to selection bias in incidence evaluation. Most population-based cancer registries have grouped cancers of the minor salivary glands with oral cancer instead of with salivary gland carcinoma as a whole, because of the international disease coding. Read More

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http://dx.doi.org/10.1186/s12885-019-5564-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458649PMC
April 2019
1 Read

Trichoblastic carcinoma arising in trichoepithelioma in Brooke-Spiegler syndrome.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):313-318

Department of Pathology, Government Medical College, Kottayam, Kerala, India.

Brooke-Spiegler syndrome (BSS) is a rare autosomal dominant disease characterized by the development of multiple cutaneous adnexal neoplasms namely cylindroma, trichoepithelioma and spiradenoma. The neoplasms associated with this syndrome are generally benign, but rarely they may undergo malignant transformation. A 63-year-old male presented with an ulcerated nodular lesion over glabella and multiple asymptomatic nodular lesions over face, scalp, chest and limbs. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_639_17DOI Listing
April 2019
1 Read

Cathepsin B defines leader cells during the collective invasion of salivary adenoid cystic carcinoma.

Int J Oncol 2019 Feb 22. Epub 2019 Feb 22.

State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu, Sichuan 610041, P.R. China.

Cathepsin B (CTSB) has been reported to be involved in cancer metastasis by altering extracellular matrix (ECM) remodeling and facilitating invasion. However, the contribution of CTSB to collective cell invasion in salivary adenoid cystic carcinoma (SACC) and the underlying mechanisms remain unclear. The present study demonstrated that collective cell invasion is commonly observed in SACC without a complete epithelial‑mesenchymal transition signature. Read More

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http://dx.doi.org/10.3892/ijo.2019.4722DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6411368PMC
February 2019

Possible Relationship Between Alterations and Specific Primary Sites in Adenoid Cystic Carcinoma: A Clinicopathological and Molecular Study of 36 Cases.

Yonago Acta Med 2019 Mar 28;62(1):67-76. Epub 2019 Mar 28.

Department of Pathology, Tottori University Hospital, Yonago 683-8504, Japan.

Background: Adenoid cystic carcinoma (ACC) is a relatively rare malignant neoplasm that occurs in salivary glands and various other organs. Recent studies have revealed that a significant proportion of ACCs harbor gene alterations involving or (mostly fusions with ) in a mutually-exclusive manner. However, its clinical significance remains to be well-established. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437404PMC

Ultrasound guided generation of PDOX models of adenoid cystic carcinoma.

EBioMedicine 2019 Apr 3. Epub 2019 Apr 3.

Department of Oral Oncology/Dentistry and Maxillofacial Prosthetics, Roswell Park Comprehensive Cancer Center, Buffalo, New York 14263, United States of America.

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http://dx.doi.org/10.1016/j.ebiom.2019.03.084DOI Listing

Fine-needle aspiration cytology of an adenoid cystic carcinoma of trachea: Common tumor in uncommon location.

Diagn Cytopathol 2019 Apr 5. Epub 2019 Apr 5.

Department of Cytology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Adenoid cystic carcinoma (ACC) is most often primary in the major and minor salivary glands but can also arise from the submucosal seromucinous glands of the larynx and trachea. We report a case of ACC of the larynx that presented as a recurrent cough for 4 months and vomiting 3 to 4 times within 1 month. Fine-needle aspiration cytology was consistent with an ACC. Read More

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http://dx.doi.org/10.1002/dc.24182DOI Listing
April 2019
6 Reads

Safety and clinical activity of the Notch inhibitor, crenigacestat (LY3039478), in an open-label phase I trial expansion cohort of advanced or metastatic adenoid cystic carcinoma.

Invest New Drugs 2019 Apr 6. Epub 2019 Apr 6.

Drug Development Department (DITEP), Institut Gustave Roussy Cancer Campus, 114 rue Edouard Vaillant, 94800, Villejuif Cedex, France.

Background Deregulated Notch signaling is implicated in multiple cancers. The phase I trial (I6F-MC-JJCA) investigated the safety and anti-tumor activity of crenigacestat (LY3039478), a selective oral Notch inhibitor, in an expansion cohort of patients with adenoid cystic carcinoma (ACC) who received the dose-escalation-recommended phase 2 dose (RP2D), established previously (Massard C, et al., Annals Oncol 2018, 29:1911-17). Read More

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http://link.springer.com/10.1007/s10637-019-00739-x
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http://dx.doi.org/10.1007/s10637-019-00739-xDOI Listing
April 2019
9 Reads

Hypoxia promotes vasculogenic mimicry formation by vascular endothelial growth factor A mediating epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.

Cell Prolif 2019 Apr 3:e12600. Epub 2019 Apr 3.

State Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology (Sichuan University), Chengdu Sichuan, China.

Objectives: To investigate the role of hypoxia in vasculogenic mimicry (VM) of salivary adenoid cystic carcinoma (SACC) and the underlying mechanism involved.

Materials And Methods: Firstly, wound healing, transwell invasion, immunofluorescence and tube formation assays were performed to measure the effect of hypoxia on migration, invasion, EMT and VM of SACC cells, respectively. Then, immunofluorescence and RT-PCR were used to detect the effect of hypoxia on VE-cadherin and VEGFA expression. Read More

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http://dx.doi.org/10.1111/cpr.12600DOI Listing

Phase II Study of Lenvatinib in Patients With Progressive, Recurrent or Metastatic Adenoid Cystic Carcinoma.

J Clin Oncol 2019 Apr 2:JCO1801859. Epub 2019 Apr 2.

1 Memorial Sloan Kettering Cancer Center, New York, NY.

Purpose: Recurrent or metastatic adenoid cystic carcinoma (R/M ACC) is a malignant neoplasm of predominantly salivary gland origin for which effective therapies are lacking. We conducted a phase II trial evaluating the multitargeted tyrosine kinase inhibitor lenvatinib in patients with R/M ACC.

Patients And Methods: This study was conducted with a two-stage minimax design. Read More

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http://dx.doi.org/10.1200/JCO.18.01859DOI Listing
April 2019
3 Reads

Aquaporins 1, 3 and 5 in Different Tumors, their Expression, Prognosis Value and Role as New Therapeutic Targets.

Pathol Oncol Res 2019 Mar 29. Epub 2019 Mar 29.

Dental Research Center, Dentistry Research Institute, Department of Oral Medicine, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.

All different types of metabolism of tumors are dependent on the flow of water molecules through the biological membrane, where fluid transfer interceded by aquaporins (AQPs) are the basis means for water entrance into the cells or outside them. Aquaporins play other roles including cellular migration, cellular expansion and cellular adhesion facilitation. Therefore, regulators of AQPs may be useful anticancer agents. Read More

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http://dx.doi.org/10.1007/s12253-019-00646-9DOI Listing

Clinically Integrated Molecular Diagnostics in Adenoid Cystic Carcinoma.

Oncologist 2019 Mar 29. Epub 2019 Mar 29.

Department of Pathology, Center for Integrated Diagnostics, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA

Background: Adenoid cystic carcinoma (ACC) is an aggressive salivary gland malignancy without effective systemic therapies. Delineation of molecular profiles in ACC has led to an increased number of biomarker-stratified clinical trials; however, the clinical utility and U.S. Read More

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http://dx.doi.org/10.1634/theoncologist.2018-0515DOI Listing
March 2019
2 Reads

Results of a combination treatment with intensity modulated radiotherapy and active raster-scanning carbon ion boost for adenoid cystic carcinoma of the minor salivary glands of the nasopharynx.

Oral Oncol 2019 Apr 27;91:39-46. Epub 2019 Feb 27.

Department of Radiation Oncology, University Hospital Heidelberg, Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Institute for Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Im Neuenheimer Feld 400, 69120 Heidelberg, Germany; Heidelberg Ion-Beam Therapy Center (HIT), Im Neuenheimer Feld 450, 69120 Heidelberg, Germany. Electronic address:

Objectives: We aimed to present the first clinical results for adenoid cystic carcinoma (ACC) of the nasopharynx after primary radiotherapy (RT) with the focus on local control (LC) and patterns of recurrence.

Materials And Methods: We retrospectively analyzed 59 patients with ACC of the nasopharynx, who were treated with bimodal radiotherapy (RT) consisting of intensity modulated radiotherapy and carbon ion boost at the Heidelberg Ion-Beam Therapy Center between 2009 and 2018. The patients had predominantly inoperable (n = 42, 72%) or incompletely resected (n = 17, 29%) tumors. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S13688375193006
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http://dx.doi.org/10.1016/j.oraloncology.2019.02.019DOI Listing
April 2019
6 Reads

Primary Adenoid Cystic Carcinoma of the Frontal Sinus: Case Description of a Previously Unreported Entity and Literature Review.

Ear Nose Throat J 2019 Mar 28:145561319837881. Epub 2019 Mar 28.

1 ENT Clinic, Head and Neck Department, Azienda Sanitaria Universitaria Integrata di Trieste, Trieste, Italy.

Sinonasal adenoid cystic carcinoma is a rare malignant epithelial tumor characterized by slow growth, multiple local recurrences, and perineural invasion; surgery followed by radiotherapy provides the best overall survival by means of an endoscopic, craniofacial, or combined approach. We present a previously undescribed case of frontal sinus adenoid cystic carcinoma involving the subcutaneous tissue and the dura mater treated with an open technique, free flap reconstruction, and hadron therapy together with a summary of the state of the art. Read More

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http://dx.doi.org/10.1177/0145561319837881DOI Listing
March 2019
1 Read

Image-guided volumetric modulated arc therapy (IG-VMAT) for unresectable ACC of the trachea: a feasible curative option.

BMJ Case Rep 2019 Mar 21;12(3). Epub 2019 Mar 21.

Department of Radiation Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, Delhi, India.

A middle-aged man presented with progressively worsening breathlessness and non-productive cough for the last 3 months. On examination, his breathing was stridulous and air entry was decreased bilaterally. He underwent emergency fibre-optic bronchoscopy, which revealed a tracheal growth causing luminal narrowing, and after tumour debulking, he improved symptomatically. Read More

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http://dx.doi.org/10.1136/bcr-2018-227128DOI Listing
March 2019
2 Reads

Genomics in non-adenoid cystic group of salivary gland cancers: one or more druggable entities?

Expert Opin Investig Drugs 2019 Mar 22:1-9. Epub 2019 Mar 22.

a Head and Neck Cancer Medical Oncology 3 Unit . Fondazione IRCCS Istituto Nazionale dei Tumori di Milano , Milan , Italy.

Introduction: Salivary gland cancers (SGCs) are a rare and heterogeneous group of malignant tumors arising from either major or minor salivary glands. Among SGCs patients, adenoid cystic carcinoma (ACC) is the most frequent histotype and its genetic aberrations are well known even though they are generally uncommon. Non-ACC subtypes are rarer and more heterogeneous than ACC from a histological and genomic point of view. Read More

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https://www.tandfonline.com/doi/full/10.1080/13543784.2019.1
Publisher Site
http://dx.doi.org/10.1080/13543784.2019.1598376DOI Listing
March 2019
5 Reads

MYB promotes the growth and metastasis of salivary adenoid cystic carcinoma.

Int J Oncol 2019 May 18;54(5):1579-1590. Epub 2019 Mar 18.

Central Laboratory, Peking University School and Hospital of Stomatology, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology, Beijing 10081, P.R. China.

The incidence of recurrent t(6;9) translocation of the MYB proto‑oncogene to NFIB (the gene that encodes nuclear factor 1 B‑type) in adenoid cystic carcinoma (ACC) tumour tissues is high. However, MYB [the gene that encodes transcriptional activator Myb (MYB)] overexpression is more common, indicating that MYB serves a key role in ACC. The current study aimed to investigate the role of MYB in salivary (S)ACC growth and metastasis. Read More

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http://www.spandidos-publications.com/10.3892/ijo.2019.4754
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http://dx.doi.org/10.3892/ijo.2019.4754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6438425PMC
May 2019
7 Reads

Challenges in Minor Salivary Gland Biopsies: A Practical Approach to Problematic Histologic Patterns.

Authors:
Lisa M Rooper

Head Neck Pathol 2019 Mar 18. Epub 2019 Mar 18.

Departments of Pathology and Oncology, The Johns Hopkins Hospital, 401 N. Broadway, Weinberg 2242, Baltimore, MD, 21231-2410, USA.

Evaluation of minor salivary gland biopsy can be fraught with a wide range of problems, including technical limitations due to the small size and distorted nature of tissue received and interpretive difficulties navigating the considerable morphologic and immunohistochemical overlap between widely disparate entities. As such, common pathologic findings can evoke a perplexing differential diagnosis that encompasses malignant, benign, and non-neoplastic processes. This review will present the diagnostic considerations that arise from four histologic patterns that are frequently encountered on minor salivary gland biopsies: squamous differentiation, tubular and cribriform growth, mucin production, and myxoid stroma. Read More

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http://dx.doi.org/10.1007/s12105-019-01010-8DOI Listing
March 2019
2 Reads

Sympathetic innervation contributes to perineural invasion of salivary adenoid cystic carcinoma via the β2-adrenergic receptor.

Onco Targets Ther 2019 21;12:1475-1495. Epub 2019 Feb 21.

State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China,

Purpose: Perineural invasion (PNI) is reported to correlate with local recurrence and poor prognosis of salivary adenoid cystic carcinoma (SACC). However, the pathogenesis of PNI remains unclear. The aims of this study were to investigate the correlation between sympathetic innervation and SACC PNI and to elucidate how the sympathetic neurotransmitter norepinephrine (NE) regulates the PNI process. Read More

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http://dx.doi.org/10.2147/OTT.S190847DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391132PMC
February 2019
4 Reads
1.342 Impact Factor

[Extirpation of primary malignancies in the pterygopalatine and infratemporal fossa via modified maxillary swing approach].

Zhonghua Kou Qiang Yi Xue Za Zhi 2019 Mar;54(3):194-197

Department of Head and Neck Surgery, Hunan Cancer Hospital, The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha 410013, China.

Five patients with primary malignancies in the pterygopalatine fossa (PPF) and infra temporal fossa (ITF) were enrolled in this retrospective study between January 2012 and January 2018. After malignancies proven by biopsy and evaluation with CT and MRI scan, all patients received modified maxillary swing (MMS) approach for extirpation of malignant tumors in the PPF and ITF under general anesthesia. En bloc resection with wide surgical margins was successfully performed in all cases. Read More

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http://dx.doi.org/10.3760/cma.j.issn.1002-0098.2019.03.009DOI Listing
March 2019
2 Reads

Analysis of clinicopathological characteristics, rearrangement and prognostic factors in salivary adenoid cystic carcinoma.

Oncol Lett 2019 Mar 15;17(3):2915-2922. Epub 2019 Jan 15.

Department of Oral and Maxillofacial-Head and Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.

Recent studies have indicated that a recurrent t(6;9)(q22-23;p23-24) chromosomal translocation in salivary adenoid cystic carcinoma (ACC) results in a MYB proto-oncogene transcription factor-nuclear factor I/B gene fusion, which has not previously been detected in any non-ACC carcinomas of the head and neck. In the present study, data on clinical factors affecting the survival rate of patients with salivary ACC from a single institution was retrospectively analyzed, and the frequency of gene rearrangement determined. A total of 97 patient cases were analyzed, and young adults presenting with ACC (<40 years old) accounted for 19. Read More

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http://dx.doi.org/10.3892/ol.2019.9935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365922PMC

Prognostic value of programed death ligand-1 and ligand-2 co-expression in salivary gland carcinomas.

Oral Oncol 2019 Mar 1;90:30-37. Epub 2019 Feb 1.

Department of Head and Neck Surgery, National Kyushu Cancer Center, Notame 3-1-1, Minami-ku, Fukuoka 811-1395, Japan. Electronic address:

Objectives: The aim of the present study was to investigate the molecular basis for the use of immune checkpoint inhibitors to treat salivary gland carcinomas (SGC).

Materials And Methods: We examined the clinical and prognostic significance of programed death ligands 1 and 2 (PD-L1 and -L2) expression using immunohistochemistry and in situ hybridization, as well as microsatellite instability (MSI) status using polymerase chain reaction, along with tumor-infiltrating lymphocytes (TILs) in 30 cases of SGC.

Results: The SGC cases studied included adenoid cystic carcinoma (AdCC, 36. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2019.01.015DOI Listing
March 2019
2 Reads

Human Papillomavirus-Related Carcinoma With Adenoid Cystic-like Features of the Sinonasal Tract (Also Known as Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma).

Arch Pathol Lab Med 2019 Mar 6. Epub 2019 Mar 6.

From the Department of Pathology, Kaohsiung Medical University Hospital (Drs Chen and Yang), and the Department of Pathology, School of Medicine, College of Medicine (Dr Yang), Kaohsiung Medical University, Kaohsiung, Taiwan.

Human papillomavirus (HPV)-related carcinoma with adenoid cystic-like features is a rare, recently recognized entity restricted to the sinonasal tract. By definition, it is associated with high-risk HPV infection, particularly with HPV type 33. In most cases, tumors are composed of dual cell populations, including predominant basaloid myoepithelial cells and usually inconspicuous ductal cells. Read More

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http://dx.doi.org/10.5858/arpa.2018-0027-RSDOI Listing
March 2019
1 Read

Combined surgery and radiotherapy as curative treatment for tracheal adenoid cystic carcinoma: a case report.

J Med Case Rep 2019 Mar 6;13(1):52. Epub 2019 Mar 6.

UOC of Oncology - ASL Latina - Distretto 1, University of Rome "Sapienza", Aprilia, LT, Italy.

Background: Adenoid cystic carcinoma of the trachea is a rare tumor, characterized by slow growth and low rate of local and distant metastasis. When achievable, complete surgical resection represents the optimal treatment approach, with the highest results in terms of overall survival. Radiation therapy is a reasonable alternative in cases of inoperable disease. Read More

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http://dx.doi.org/10.1186/s13256-019-1996-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402121PMC
March 2019
1 Read

[Clinicopathological features and prognostic factors of primary pulmonary adenoid cystic carcinoma: a study of 59 cases].

Zhonghua Bing Li Xue Za Zhi 2019 Mar;48(3):204-208

Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathological features and prognostic indicators of primary pulmonary adenoid cystic carcinoma. Fifty-nine cases of primary pulmonary adenoid cystic carcinoma were collected from August 2011 to December 2017 at the First Affiliated Hospital of Zhengzhou University. All cases were retrospectively studied by hematoxylin-eosin staining and immunohistochemistry. Read More

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.03.007DOI Listing
March 2019
4 Reads

Treatment-induced changes of lymphocyte subsets in patients with adenoid cystic carcinoma of the head and neck.

Eur Arch Otorhinolaryngol 2019 May 28;276(5):1465-1473. Epub 2019 Feb 28.

Department of Otorhinolaryngology, Head and Neck Surgery, Ulm University Medical Center, University of Ulm, Frauensteige 12, 89075, Ulm, Germany.

Purpose: Adenoid cystic carcinoma (ACC) of the head and neck is a rare and highly malignant tumor, characterized by perineural growth and early distant metastases. The composition of immune cells in the peripheral blood and the tumor microenvironment is critical to tumor growth and control. However, little is known about the frequency and function of the relevant immune cell subsets in this entity. Read More

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http://dx.doi.org/10.1007/s00405-019-05363-2DOI Listing
May 2019
1 Read

Bronchoscopic observation with linked colour imaging.

Respirol Case Rep 2019 Apr 14;7(3):e00399. Epub 2019 Feb 14.

Department of General Thoracic Surgery Jichi Medical University Shimotsuke Japan.

We report two cases of the comparison of diagnosis made with linked color imaging (LCI) and conventional white-light imaging (WLI) on the same patients. In case 1, a 75-year-old man in whom right upper lobectomy with mediastinal lymph node dissection was performed due to lung cancer had signs of bronchitis on postoperative day 8. The LCI demonstrated slight inflammatory changes that were not detectable with the conventional WLI on the tracheal wall. Read More

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http://dx.doi.org/10.1002/rcr2.399DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375225PMC

Adenoid cystic carcinoma presenting with bilateral orbital extension from the soft palate.

Digit J Ophthalmol 2018 18;24(1):1-5. Epub 2018 Feb 18.

Department of Ophthalmology, Rhode Island Hospital, Providence, Rhode Island.

Adenoid cystic carcinoma (ACC) is a rare neoplasm of secretory epithelium that most commonly occurs in the fifth and sixth decades of life. It is characterized by high recurrence rates and poor response to chemotherapy, In the orbit, ACC usually presents as a lacrimal gland mass. We describe the rare case of a 70-year-old woman who presented with pain during mastication and bilateral facial numbness in the cranial nerve V2 distribution. Read More

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http://dx.doi.org/10.5693/djo.02.2018.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6380254PMC
March 2019
7 Reads

Recurrence patterns of sinonasal cancers after a 5-year disease-free period.

Laryngoscope 2019 Feb 22. Epub 2019 Feb 22.

Department of Otorhinolaryngology-Head and Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.

Objectives/hypothesis: Sinonasal cancers are rare but have a poor prognosis. Most previous studies of these cancers have focused on 5-year disease-free survival, but recurrences are also known to occur after this period. We examined the post-5-year recurrence patterns in sinonasal cancer patients by histologic type to determine the indicators for extended and close follow-up requirements. Read More

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http://dx.doi.org/10.1002/lary.27866DOI Listing
February 2019
4 Reads

Adenoid cystic carcinoma with high-grade transformation forming spindle cell component of the submandibular gland.

Auris Nasus Larynx 2019 Feb 15. Epub 2019 Feb 15.

Department of Pathology, Fukuoka University, School of Medicine, Japan.

Adenoid cystic carcinoma (AdCC) with high-grade transformation (AdCC-HGT) is rare, and AdCC-HGT with spindle cell component is particularly rare. The patient was a 65-year-old man with a 5 cm sized swelling of the right submandibular gland. Submandibular sialoadenectomy was performed. Read More

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http://dx.doi.org/10.1016/j.anl.2019.01.014DOI Listing
February 2019

Necrotizing sialometaplasia can hide the presence of salivary gland tumors: A case series.

Oral Dis 2019 May 5;25(4):1084-1090. Epub 2019 Mar 5.

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: Necrotizing sialometaplasia (NS) is an uncommon benign process which affects minor and, more rarely, major salivary glands. While self-limiting, the condition might be clinically and histologically mistaken for malignancy. Furthermore, NS may accompany neoplasms. Read More

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http://doi.wiley.com/10.1111/odi.13066
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http://dx.doi.org/10.1111/odi.13066DOI Listing
May 2019
16 Reads

Nodular Cystic Variant of Basal Cell Carcinoma: Perfect Correlation Between Histopathology and Confocal Microscopy.

Dermatol Pract Concept 2019 Jan 31;9(1):67-68. Epub 2019 Jan 31.

Department of Dermatology and Venereology, Hospital Universitario Fundación Alcorcón, Madrid, Spain.

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http://dx.doi.org/10.5826/dpc.0901a15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368071PMC
January 2019

Carbon-ion radiotherapy in accelerated hypofractionated active raster-scanning technique for malignant lacrimal gland tumors: feasibility and safety.

Cancer Manag Res 2019 1;11:1155-1166. Epub 2019 Feb 1.

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg 69120, Germany,

Introduction: We evaluated treatment outcomes of CIRT in an active raster-scanning technique alone or in combination with IMRT for lacrimal gland tumors.

Methods: A total of 24 patients who received CIRT for a malignant lacrimal gland tumor at the HIT between 2009 and 2018 were analyzed retrospectively for LC, OS, and distant progression-free survival (DPFS) using Kaplan-Meier estimates. Toxicity was assessed according to the CTCAE version 5. Read More

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http://dx.doi.org/10.2147/CMAR.S190051DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6362930PMC
February 2019
1 Read

[Study of surgery combined with I brachytherapy for adenoid cystic carcinoma of oral and maxillofacial region].

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Feb;51(1):49-52

Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.

Objective: To retrospectively analyze the results of treatment outcome by surgery combined with I brachytherapy and correlative factors of adenoid cystic carcinoma (ACC).

Methods: In the study, 75 patients with primary ACC of oral and maxillofacial region were treated by surgery combined with I seeds brachytherapy. Radical resection or subtotal resection was applied for the tumor. Read More

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http://dx.doi.org/10.19723/j.issn.1671-167X.2019.01.009DOI Listing
February 2019

Application of diffusion-weighted MR imaging with ADC measurement for distinguishing between the histopathological types of sinonasal neoplasms.

Clin Imaging 2019 Feb 7;55:76-82. Epub 2019 Feb 7.

Department of Radiology, University of Minnesota Medical Center, Minneapolis, MN, USA. Electronic address:

Purpose: To evaluate the potential contribution of quantitative DWI parameters including ADC and ADC values to help in distinguishing the histopathological types of sinonasal neoplasms.

Methods: This retrospective study included 83 patients (50 males, 33 females; mean age 61 years) with pathologically proven untreated sinonasal neoplasms who have undergone diffusion-weighted MRI imaging from February 2010 to August 2017. Diffusion-weighted MRI was performed on a 3 T unit with b factors of 0 and 1000 s/mm, and ADC maps were generated. Read More

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http://dx.doi.org/10.1016/j.clinimag.2019.02.004DOI Listing
February 2019

Serial patient-derived orthotopic xenografting of adenoid cystic carcinomas recapitulates stable expression of phenotypic alterations and innervation.

EBioMedicine 2019 Mar 11;41:175-184. Epub 2019 Feb 11.

University of Michigan, Biointerfaces Institute, Ann Arbor, MI, United States; University of Michigan, School of Dentistry, Department of Biologic and Materials Sciences, Ann Arbor, MI, United States. Electronic address:

Background: Patient-derived xenograft (PDX) models have significantly enhanced cancer research, and often serve as a robust model. However, enhanced growth rate and altered pathological phenotype with serial passages have repeatedly been shown in adenoid cystic carcinoma (ACC) PDX tumors, which is a major concern.

Methods: We evaluated the fidelity of ACCs in their natural habitat by performing ACC orthotopic xenotransplantation (PDOX) in salivary glands. Read More

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http://dx.doi.org/10.1016/j.ebiom.2019.02.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6442226PMC
March 2019
2 Reads

The value of MYB as a prognostic marker for adenoid cystic carcinoma: Meta-analysis.

Head Neck 2019 May 13;41(5):1517-1524. Epub 2019 Feb 13.

Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University, Guangzhou, Guangdong, China.

The aim of this meta-analysis is to evaluate myeloblastosis (MYB) as a prognostic marker for patients with adenoid cystic carcinoma (ACC) with respect to MYB gene fusion, MYB protein expression, and tumor sites. We comprehensively searched PubMed, Embase, Web of Science, and Cochrane libraries. Ten studies concerning the prognostic comparisons between MYB positivity and negativity were included. Read More

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http://dx.doi.org/10.1002/hed.25597DOI Listing
May 2019
2 Reads

Autophagy-related gene expression regulated by HIF-1α in salivary adenoid cystic carcinoma.

Oral Dis 2019 May 3;25(4):1076-1083. Epub 2019 Mar 3.

Department of Oral and Maxillofacial Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.

Objectives: Salivary adenoid cystic carcinoma (SACC) is one of the most common malignant salivary gland tumors. Our study aims to investigate whether hypoxia-induced autophagy was up-regulated in the progression of SACC.

Materials And Methods: We performed differentially expressed gene analysis and pathway enrichment analysis and then calculated the correlation analysis on GSE59701 and GSE28996 datasets. Read More

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http://dx.doi.org/10.1111/odi.13058DOI Listing
May 2019
5 Reads

CT features and differential diagnosis of primary pulmonary mucoepidermoid carcinoma and pulmonary adenoid cystic carcinoma.

J Thorac Dis 2018 Dec;10(12):6501-6508

Department of Radiology, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China.

Background: The differential diagnosis of primary pulmonary mucoepidermoid carcinoma (PMEC) and pulmonary adenoid cystic carcinoma (PACC) is difficult, because both tumors could be similar in terms of certain characteristics on CT.

Methods: The CT findings from 24 cases of PMEC and 30 cases of PACC were retrospectively analyzed. According to the position of the lesion in airway, we divided these cases into three types: central, hilar, and peripheral. Read More

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http://dx.doi.org/10.21037/jtd.2018.11.71DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344748PMC
December 2018
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Pretreatment assessment of hematologic and inflammatory markers in adenoid cystic carcinoma: neutrophil/lymphocyte ratio is associated with multiple recurrences.

Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Oct 30. Epub 2018 Oct 30.

Department of Otorhinolaryngology, Medical University of Vienna, Vienna, Austria.

Objective: Adenoid cystic carcinoma (ACC) is a rare entity of salivary gland cancer. Inflammatory and hematologic markers and their prognostic and predictive value have been intensively studied in several cancer entities. The aim of this study was to investigate the role of such markers in patients with ACC. Read More

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http://dx.doi.org/10.1016/j.oooo.2018.10.009DOI Listing
October 2018
2 Reads

More than meets the eye.

BMJ Case Rep 2019 Feb 7;12(2). Epub 2019 Feb 7.

Department of Otolaryngology Head and Neck Surgery, St. James's Hospital, Dublin, Ireland.

We report an extremely rare case of a hybrid tumour of the maxillary sinus. A 51-year-old man presented with a 6-week history of nasal congestion and epiphora. Radiological imaging demonstrated a maxillary sinus tumour, with extensive local invasion. Read More

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http://dx.doi.org/10.1136/bcr-2015-212000DOI Listing
February 2019
4 Reads

Role of apoptotic, autophagic and senescence pathways in minor salivary gland adenoid cystic carcinoma.

Diagn Pathol 2019 Feb 8;14(1):14. Epub 2019 Feb 8.

Department of Oral Pathology, São Leopoldo Mandic Research Institute, Rua José Rocha Junqueira, 13, CEP, Campinas, SP, 13045-610, Brazil.

Background: Adenoid cystic carcinoma (ACC) is a salivary gland malignancy with poor long-term survival, which warrants studies aimed at clarifying the pathogenesis of this disease in order to widen the scope of therapeutic options currently available. Alterations in regulatory mechanisms relating to vascular support, cell death and autophagy are important pathways for tumor growth in cancer. Thus, the present study aimed to access vascular supply, apoptosis, autophagy and cell senescence in ACC of minor salivary glands. Read More

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http://dx.doi.org/10.1186/s13000-019-0796-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368765PMC
February 2019
1 Read

CXCR4 and PD-1 Expression in Head and Neck Cancer with Perineural Spread.

J Neurol Surg B Skull Base 2019 Feb 14;80(1):18-22. Epub 2018 Jun 14.

School of Medicine, University of Queensland, Brisbane, Queensland, Australia.

 Perineural spread (PNS) is a marker of aggressiveness and has been shown to occur in cranial nerves due to advanced mucosal and cutaneous head and neck cancer. Receptors CXC chemokine receptor 4 (CXCR4) and programmed cell death-1 (PD-1) have been shown to be overexpressed in a variety of cancers with PNS, with the inhibition of these pathways offering a potential future treatment.  Retrospective immunohistochemical staining for the CXCR4 and PD-1 receptors was performed on 28 head and neck specimens that demonstrated PNS from January 2017 to August 2017, at Royal Brisbane and Women's Hospital, Brisbane, Australia. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/s-0038-1660846
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http://dx.doi.org/10.1055/s-0038-1660846DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6365291PMC
February 2019
9 Reads

Personalized Treatment for Lacrimal Sac Adenoid Cystic Carcinoma: Case Report and Literature Review.

Pract Radiat Oncol 2019 Feb 4. Epub 2019 Feb 4.

Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.

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http://dx.doi.org/10.1016/j.prro.2019.01.011DOI Listing
February 2019

Fibroblast growth factor receptor 1 (FGFR1) as a therapeutic target in adenoid cystic carcinoma of the lacrimal gland.

Oncotarget 2019 Jan 11;10(4):480-493. Epub 2019 Jan 11.

Dr. Nasser Al-Rashid Orbital Vision Research Center, Bascom Palmer Eye Institute, Department of Ophthalmology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

Identification of molecular targets is the first step in developing efficacious therapeutic strategies for tumors. A tumors' biological response to perturbagens yields important information on the molecular determinants for tumor growth. The aim of this study was to characterize the response of adenoid cystic carcinoma of the lacrimal gland (LGACC) to intra-arterial cytoreductive chemotherapy (IACC) in order to identify novel targets to enhance therapy. Read More

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http://dx.doi.org/10.18632/oncotarget.26558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355187PMC
January 2019
1 Read

The role of organ- and function-preserving radiotherapy in the treatment of adenoid cystic carcinoma of the larynx.

Head Neck 2019 Feb 5. Epub 2019 Feb 5.

Department of Radiation Oncology, University Hospital Heidelberg, Heidelberg, Germany.

Background: To evaluate clinical outcome and functional larynx preservation after radiotherapy (RT) for adenoid cystic carcinoma (ACC) of the larynx.

Methods: Eleven patients with primary ACC of the larynx, who received RT definitely (n = 5/11) or postoperatively (n = 6/11), were analyzed regarding survival and treatment-related toxicity with the focus on functional larynx preservation.

Results: Median follow-up was 45 months. Read More

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http://dx.doi.org/10.1002/hed.25678DOI Listing
February 2019
4 Reads