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    Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Diagnosed in the Foot: A Case Report.
    J Am Podiatr Med Assoc 2017 May 22. Epub 2017 May 22.
    § Trinitas Regional Medical Center Residency Director.
    Adenoid cystic carcinoma is a rare, slow-growing neoplasm. It is most commonly located in the salivary glands, affects people older than 55 years of age, and has a predilection for women. These lesions may recur locally but have shown low metastatic potential. Read More

    Can the onset of orbital cancer be the result of a prosthetic eye?
    Acta Otorhinolaryngol Ital 2017 May 22. Epub 2017 May 22.
    ENT Department, University "G. d'Annunzio" of Chieti-Pescara, Hospital "SS Annunziata",Chieti, Italy.
    Orbital exenteration is a disfiguring procedure performed for unresponsive orbital infections and control of recurrent benign tumours and malignancies arising from the eyelids (basal cell carcinoma, squamous cell carcinoma, conjunctival malignant melanoma), lachrymal glands (adenoid cystic carcinoma) or surrounding sinuses. In extremely rare cases the use of a prosthetic eye after enucleation can lead to anophthalmic socket tumours. We report the case of a 54-year-old man who had left eye enucleation due to recurring events of retinal detachment and who developed an invasive fast growing epidermoid carcinoma 30 years later. Read More

    Prognostic factors of adenoid cystic carcinoma of the head and neck in carbon-ion radiotherapy: The impact of histological subtypes.
    Radiother Oncol 2017 May 18. Epub 2017 May 18.
    Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
    Purpose: The aim of this study was to evaluate the effect of histological subtypes of head and neck adenoid cystic carcinoma (ACC) on the results of carbon-ion radiotherapy (CIRT).

    Material And Methods: Of the 113 patients with ACC who were treated with CIRT between December 2006 and July 2013, 100 patients with identified histological subtypes were enrolled in this study. CIRT at a total dose of 57. Read More

    MicroRNA-320a is downregulated in non-small cell lung cancer and suppresses tumor cell growth and invasion by directly targeting insulin-like growth factor 1 receptor.
    Oncol Lett 2017 May 14;13(5):3247-3252. Epub 2017 Mar 14.
    College of Life Sciences, Agricultural University of Hebei, Baoding, Hebei 071001, P.R. China.
    Accumulating evidence has demonstrated that microRNAs (miRs/miRNAs) are implicated in carcinogenesis and cancer progression, and can function as oncogenes or tumor suppressor genes in human cancer types. Previous profile studies of miRNA expression levels have revealed that miR-320a was downregulated in breast cancer, colon cancer, bladder cancer, glioblastoma and salivary adenoid cystic carcinoma. However, its expression level, potential functions and the mechanisms underlying its functions in non-small cell lung cancer (NSCLC) require further investigation. Read More

    Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Diagnosed in the Foot: A Case Report.
    J Am Podiatr Med Assoc 2017 May 17. Epub 2017 May 17.
    § Trinitas Regional Medical Center Residency Director.
    Adenoid cystic carcinoma is a rare, slow-growing neoplasm. It is most commonly located in the salivary glands, affects people older than 55 years of age, and has a predilection for women. These lesions may recur locally but have shown low metastatic potential. Read More

    Use of fluorescent in-situ hybridisation in salivary gland cytology: A powerful diagnostic tool.
    Cytopathology 2017 May 15. Epub 2017 May 15.
    Rangueil Medical School, Histology and Embryology, Toulouse III Paul Sabatier University, Toulouse Cedex, France.
    Objective: Salivary gland cytology is challenging because it includes a diversity of lesions and a wide spectra of tumours. Recently, it has been reported that many types of salivary gland tumours have specific molecular diagnostic signatures that could be identified by fluorescent in-situ hybridisation (FISH). The aim of the present study was to demonstrate the feasibility and efficiency of FISH on routine cytological salivary gland smears. Read More

    MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma.
    Stem Cell Res 2017 May 5;21:160-166. Epub 2017 May 5.
    Division of Otolaryngology, Department of Surgery, Yale School of Medicine, New Haven, CT, United States. Electronic address:
    Cancer stem cells (CSC) are considered the major cause of aggressive tumor behavior, recurrence, metastases, and resistance to radiation, making them an attractive therapeutic target. However, isolation of CSC from tumor tissue and their characterization are challenging due to uncertainty about their molecular markers and conditions for their propagation. Adenoid cystic carcinoma (ACC), which arises predominantly in the salivary glands, is a slow-growing but relentless tumor that frequently invades nerves and metastasizes. Read More

    MYB Labeling by Immunohistochemistry is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH.
    Am J Surg Pathol 2017 May 11. Epub 2017 May 11.
    Departments of *Pathology †Oncology, The Johns Hopkins Hospital, Baltimore, MD.
    Breast adenoid cystic carcinoma (ACC) is a primary breast carcinoma that, like salivary gland ACC, displays the t(6;9) translocation resulting in the MYB-NFIB gene fusion and immunopositivity for MYB by immunohistochemistry (IHC). However, it is not well established whether MYB immunoreactivity or rearrangement can be used to support a diagnosis of ACC in a malignant basaloid or benign cribriform breast lesion. Whole sections of primary breast ACC (n=11), collagenous spherulosis (CS; n=7), and microglandular adenosis (MGA; n=5) and tissue microarrays containing 16 basal-like, triple-negative breast carcinomas (TNBC) were labeled for MYB by IHC and underwent MYB fluorescence in situ hybridization using a break-apart probe. Read More

    Adenoid Cystic Carcinoma of the Larynx Presenting as a Thyroid Mass and Brief Literature Review.
    Acta Cytol 2017 May 11. Epub 2017 May 11.
    Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
    Background: Adenoid cystic carcinoma (ACC) of the larynx and trachea is very rare.

    Case: A 45-year-old man with ACC of the larynx presenting as a thyroid mass is reported in this study. Physical examination revealed a large solid thyroid nodule in the left lobe without any lymphadenopathy. Read More

    Epigallocatechin gallate inhibits the growth of salivary adenoid cystic carcinoma cells via the EGFR/Erk signal transduction pathway and the mitochondria apoptosis pathway.
    Neoplasma 2017 May 9;64. Epub 2017 May 9.
    ACC is one of the most malignant tumors in salivary gland, and of poor prognosis. A critical role in ACC development and progression is played by EGFR family members including EGFR. EGCG, a low molecular weight polyphenol contained in green tea, has broad anticancer properties, but whether EGCG regulates activity of ACC is unknown. Read More

    Cytology of Primary Salivary Gland-Type Tumors of the Lower Respiratory Tract: Report of 15 Cases and Review of the Literature.
    Front Med (Lausanne) 2017 24;4:43. Epub 2017 Apr 24.
    Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
    Primary pulmonary salivary gland-type tumors are rare neoplasms arising from the seromucinous submucosal glands of the lower respiratory tract (LRT), the most common of which are mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma. They are morphologically indistinguishable from their salivary gland counterpart and recognizing them is a challenge, especially on cytological specimens. We analyzed 15 cases of histologically proven primary salivary gland tumors of the LRT to identify cytomorphological features and define potential diagnostic clues that might assist cytopathologists in the preoperative diagnosis of these neoplasias. Read More

    Metastatic Intracranial Adenoid Cystic Carcinoma with Unknown Primary: Case Report and Review of Literature.
    J Neurosci Rural Pract 2017 Apr-Jun;8(2):274-276
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Hosur Road, Bengaluru, Karnataka, India.
    Adenoid cystic carcinoma (ACC) is an epithelial malignancy comprising approximately 8-10% of all salivary gland tumors. Intracranial ACC without a known primary is an extremely rare pathobiological event. Only 13 cases have been reported in available literature. Read More

    Histopathological study of salivary gland tumors.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):46-50
    Department of Pathology, S Nijalingappa Medical College, Hanagal Shree Kumareshwar Hospital and Research Centre, Medical College and Hospital, Bagalkot, Karnataka, India.
    Context: The salivary glands are the site of origin of a wide variety of neoplasms and are also relatively uncommon. The histopathology of these tumors is said to be the most complex and diverse of any organ in the body. The incidence of salivary gland tumors (SGTs) is claimed to be influenced by geographical and racial factors. Read More

    Parotid adenoid cystic carcinoma: Retrospective single institute analysis.
    Am J Otolaryngol 2017 Mar 31. Epub 2017 Mar 31.
    Otorhinolaryngology-Head and Neck Surgery Unit, Department of Surgery and Translational Medicine, University of Florence, AOU-Careggi, Via Largo Palagi 1, 50134 Florence, Italy.
    Purpose: Adenoid cystic carcinoma (ACC) is a uncommon salivary malignant tumor. Our aim was to review our experience with parotid ACC, to identify clinical-pathological parameters predictive for outcome.

    Materials And Methods: We retrospectively reviewed 228 patients affected by parotid gland carcinomas surgically treated at our Institution. Read More

    Full Mouth Reconstruction of a Skeletal Class II Division 1 Patient with Adenoid Cystic Carcinoma Using an Interim Immediate Obturator and a Definitive Obturator.
    Case Rep Dent 2017 4;2017:5458617. Epub 2017 Apr 4.
    Dental Research Center, Department of Prosthodontics, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
    A 61-year-old female patient with adenoid cystic carcinoma (ACC) of the right maxilla and Angle class II division 1 malocclusion had received a subtotal maxillectomy in right side and used a conventional clasp-retained obturator. After implants placement, a maxillary interim immediate obturator (IIO) and then a definitive obturator using six endosseous implants were fabricated. During one-year follow-up, the patient was completely satisfied. Read More

    BSND is a Novel Immunohistochemical Marker for Oncocytic Salivary Gland Tumors.
    Pathol Oncol Res 2017 May 3. Epub 2017 May 3.
    Department of Tumor Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi Ward, Hamamatsu, 431-3192, Japan.
    BSND protein, which is involved in chloride transport, is expressed in normal kidney and the inner ear and is known as an immunohistochemical marker for chromophobe renal cell carcinoma (RCC) and renal oncocytoma; however, other organs and tumor types exhibiting BSND expression have not yet been reported. In this study, we investigated the expression of BSND using data from the Cancer Genome Atlas (TCGA) database and by performing immunohistochemical analyses. As a result, we found that BSND was also expressed in the striated duct cells of normal salivary glands. Read More

    Adenoid cystic carcinoma of the breast, 20 years of experience in a single center with review of literature.
    Breast Cancer 2017 May 2. Epub 2017 May 2.
    Mount Sinai Medical Center, Department of Surgery, 4300 Alton Road, Miami Beach, FL, 33140, USA.
    Background: Adenoid cystic carcinoma (ACC) of the breast is a rare type of breast cancer, which presents inconsistencies in the optimal management strategy.

    Methods: A retrospective review of prospectively collected data, spanning the last 20 years, was performed using the cancer registry database at our institution.

    Results: Six patients were diagnosed with ACC of the breast, out of 5,813 total patients diagnosed with breast cancer (0. Read More

    Lung metastases from cutaneous adenoid cystic carcinoma 23 years after initial treatment.
    Respir Med Case Rep 2017 19;21:121-123. Epub 2017 Apr 19.
    Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-Ku, Tokyo, 113-8431, Japan.
    Cutaneous adenoid cystic carcinoma (CACC) is an extremely rare neoplasm of head and neck region, and is characterized by propensity for local recurrence and perineural invasion. Late distant metastases occur usually to lungs. Although patients with lung metastases from CACC cannot be cured, long-term survival may be possible due to its slow-growing malignancy. Read More

    Expression of cancer cell-derived IgG and extra domain A-containing fibronectin in salivary adenoid cystic carcinoma.
    Arch Oral Biol 2017 Apr 21;81:15-20. Epub 2017 Apr 21.
    Central Laboratory, Peking University School and Hospital of Stomatology, 22 South Zhongguancun Avenue, Haidian District, Beijing 100081, China. Electronic address:
    Objective: Cancer-IgG is a newly-discovered molecule, mainly derived from epithelial carcinoma cells and is significantly correlated with differentiation, metastasis, local invasion, and poor prognosis of many cancers. In our previous study we detected IgG expression in oral epithelial carcinoma, including salivary adenoid cystic carcinoma (SACC), using an IgG-specific commercial antibody. Here, we explored the correlation between cancer-IgG and clinicopathological features of SACC. Read More

    Resection of upper lip adenoid cystic carcinoma and reconstruction with reverse Yu flap: Report of three cases and a literature review.
    Mol Clin Oncol 2017 Mar 3;6(3):444-450. Epub 2017 Feb 3.
    Department of Oral and Maxillofacial Surgery, Virgen Del Rocio University Hospital, 41013 Seville, Spain.
    The present study aimed to describe the techniques that were used, and the results obtained, with the reverse Yu flap to reconstruct medium-sized upper lip defects following resection for adenoid cystic carcinoma (ACC). Data concerning the clinical and pathological characteristics of tumours, the size and location of the defects, surgical resection and the reconstructive procedure used were evaluated in three patients, as well as postoperative complications and outcomes. In all cases, a complete surgical removal of ACC was achieved with clear margins of at least 1 cm. Read More

    New tumor entities in the 4th edition of the World Health Organization classification of head and neck tumors: Nasal cavity, paranasal sinuses and skull base.
    Virchows Arch 2017 Apr 25. Epub 2017 Apr 25.
    Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
    The World Health Organization recently published the 4th edition of the Classification of Head and Neck Tumors, including several new entities, emerging entities, and significant updates to the classification and characterization of tumor and tumor-like lesions, specifically as it relates to nasal cavity, paranasal sinuses, and skull base in this overview. Of note, three new entities (NUT carcinoma, seromucinous hamartoma, biphenotypic sinonasal sarcoma,) were added to this section, while emerging entities (SMARCB1-deficient carcinoma and HPV-related carcinoma with adenoid cystic-like features) and several tumor-like entities (respiratory epithelial adenomatoid hamartoma, chondromesenchymal hamartoma) were included as provisional diagnoses or discussed in the setting of the differential diagnosis. The sinonasal tract houses a significant diversity of entities, but interestingly, the total number of entities has been significantly reduced by excluding tumor types if they did not occur exclusively or predominantly at this site or if they are discussed in detail elsewhere in the book. Read More

    Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.
    Stem Cell Res 2017 Apr 8;21:94-105. Epub 2017 Apr 8.
    Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

    Model to Predict Cause-Specific Mortality in Patients with Head and Neck Adenoid Cystic Carcinoma: A Competing Risk Analysis.
    Ann Surg Oncol 2017 Apr 19. Epub 2017 Apr 19.
    Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, 157-8535, Japan.
    Purpose: The main objective of this study was to evaluate the cumulative incidence of cause-specific death and other causes of death for patients with head and neck adenoid cystic carcinoma (ACC). The secondary aim was to model the probability of cause-specific death and build a competing risk nomogram to predict cause-specific mortality for this disease.

    Methods: Data were extracted from the US National Cancer Institute's Surveillance Epidemiology, and End Results (SEER)-18 dataset. Read More

    A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma.
    Oncotarget 2017 May;8(20):32918-32929
    Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
    Purpose: Vorinostat is a histone deacetylase inhibitor (HDACi). Based on a confirmed partial response (PR) in an adenoid cystic carcinoma (ACC) patient treated with vorinostat in a prior phase 1 trial, we initiated this phase 2 trial.

    Methods: Vorinostat was administered orally 400 mg daily, 28 day cycles. Read More

    An Update on Tumors of the Lacrimal Gland.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172
    Department of Pathology, Rigshospitalet, University of Copenhagen, Cophenhagen, Denmark.
    Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to high-grade carcinomas, lymphomas, and sarcomas with large differences in prognosis and clinical management. The symptoms and findings of a lacrimal gland lesion are a growing mass at the site of the lacrimal gland, including displacement of the eyeball, decreased motility, diplopia, and ptosis. Pain is the cardinal symptom of an adenoid cystic carcinoma. Read More

    Perineural spread-susceptible structures: a non-pathological evaluation of the skull base.
    Eur Arch Otorhinolaryngol 2017 Apr 7. Epub 2017 Apr 7.
    Department of Human Anatomy, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Ave. Madero y Calle Dr. Eduardo Aguirre Pequeño s/n, Colonia Mitras Centro, CP 64460, Monterrey, Nuevo Leon, Mexico.
    Perineural spread adenoid cystic carcinoma can alter the dimension of foramina and canals of the skull base. The objective of this study was to determine the range of normal variation of the foramina and canals of both hemicranium. We analyzed 200 individuals with no alterations of the skull base in a retrospective manner using high-resolution computed tomography. Read More

    B7-H3 regulates migration and invasion in salivary gland adenoid cystic carcinoma via the JAK2/STAT3 signaling pathway.
    Am J Transl Res 2017 15;9(3):1369-1380. Epub 2017 Mar 15.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan UniversityWuhan, China; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan UniversityWuhan, China.
    B7 Homolog 3 (B7-H3), a newly identified member of the B7 family, is over-expressed in various human cancers and plays a vital role in tumor progression. To identify the expression pattern of B7-H3 in human salivary adenoid cystic carcinoma (AdCC) and its underlying mechanisms, we characterized B7-H3 expression in AdCC tissue microarrays using immunohistochemical staining, and analyzed potentially associated molecules. The results showed that B7-H3 was highly expressed in salivary AdCC, compared with normal salivary glands. Read More

    Down-regulation of miR-125a-5p is associated with salivary adenoid cystic carcinoma progression via targeting p38/JNK/ERK signal pathway.
    Am J Transl Res 2017 15;9(3):1101-1113. Epub 2017 Mar 15.
    Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangzhou, China; Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangzhou Higher Education Institutes, Sun Yat-Sen UniversityGuangzhou, China.
    Salivary adenoid cystic carcinoma (SACC) is a relatively uncommon epithelial-like malignancy that can occur in the head and neck region. Despite its slow growth, this aggressive salivary gland tumor frequently recurs and metastasizes to distant organs since lacking effective chemotherapy treatment. MicroRNAs are key regulators in tumor metastasis and progression, but their roles during SACC progression have not been illustrated. Read More

    Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography.
    J Med Ultrason (2001) 2017 Apr 5. Epub 2017 Apr 5.
    Department of Ultrasound, The First Affiliated Hospital of Zhejiang University, #79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
    Adenoid cystic carcinoma (ACC) of the breast is a rare malignant tumor. Its sonographic characteristics have been described in some reports, but there are few such reports available that describe the sonoelastographic findings of this tumor and provide additional information about the nature of the lesion. In this case report, we describe the routine sonographic findings and shear wave elastography findings of a breast adenoid cystic carcinoma in a 53-year-old woman. Read More

    A Phase II study of Dovitinib in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma.
    Clin Cancer Res 2017 Apr 4. Epub 2017 Apr 4.
    Medicine, Wake Forsest University.
    Purpose: Genetic and preclinical studies have implicated fibroblast growth factor receptor (FGFR) signaling in the pathogenesis of adenoid cystic carcinoma (ACC). Dovitinib, a suppressor FGFR activity, may be active in ACC.

    Methods: In a two-stage phase II study, 35 patients with progressive ACC were treated with dovitinib 500mg orally for 5 of 7 days continuously. Read More


    Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus.
    Head Neck 2017 Apr 3. Epub 2017 Apr 3.
    Department of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
    Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV).

    Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. Read More

    Expression of Cancer-Testis Antigens in Salivary Gland Carcinomas with Reference to MAGE-A and NY-ESO-1 Expression in Adenoid Cystic Carcinoma.
    Histopathology 2017 Mar 28. Epub 2017 Mar 28.
    Department of Pathology and Molecular Diagnostics, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
    Background: Salivary gland carcinomas comprise a group of heterogeneous lesions with complex clinicopathological characteristics and distinct biological behaviors. However, recurrent or metastatic tumors are difficult to treat with currently available therapies. Cancer-testis antigens (CTAs) are detected in cancer cells but not in healthy normal tissues, with the exception of gametogenic tissues. Read More

    Analysis of orbital malignancies presenting in a tertiary care hospital in Pakistan.
    Pak J Med Sci 2017 Jan-Feb;33(1):70-74
    Dr. Sibghat-ul-Noor, MBBS. Institute of Ophthalmology/College of Ophthalmology and Allied Vision Sciences, King Edward Medical University, Mayo Hospital, Lahore, Pakistan.
    Objective: To determine the frequencies of various orbital malignancies amongst orbital lesions in patients presenting in a tertiary care hospital in Pakistan.

    Methods: A retrospective analysis of 666 orbital cases with an established histopathological diagnosis of malignant tumors treated in Mayo Hospital Lahore from 1996 to 2015 (20 years).

    Results: About 66% of the malignant tumors were primary, 25% secondary, 8% haematopoietic and 1% metastatic. Read More

    Adenoid Cystic Carcinoma of the Uterine Cervix: A Report of 2 Cases.
    Case Rep Pathol 2017 28;2017:8401741. Epub 2017 Feb 28.
    Department of Pathology, National Institute of Oncology, Rabat, Morocco.
    Adenoid cystic carcinoma is malignant tumor that exceptionally occurs in the uterine cervix. It is mostly seen in postmenopausal women and has an aggressive clinical course. We report two cases of an adenoid cystic carcinoma associated with a high grade squamous intraepithelial lesion and invasive squamous cell carcinoma of the uterine cervix and discuss briefly its clinical and pathological characteristics. Read More

    Submandibular salivary gland tumors: Clinical course and outcome of a 20-year multicenter study.
    Ear Nose Throat J 2017 Mar;96(3):E17-E20
    Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tikva 49100, Israel.
    The purpose of this retrospective chart review study was to review the nature and clinical course of benign and malignant submandibular gland tumors at 2 major university-affiliated tertiary medical centers. All patients who underwent submandibular salivary gland excision between 1990 and 2010 were included. Clinical and disease-related data were collected from the medical charts. Read More

    Lung metastasectomy in adenoid cystic cancer: Is it worth it?
    Oral Oncol 2017 Feb 26;65:114-118. Epub 2016 Oct 26.
    Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milan, Italy; Thoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
    Background And Purpose: Adenoid cystic carcinoma (ACC) of salivary glands is characterized by long-term distant metastasis, most commonly in lungs. No agreement has been reached about the role of surgical treatment of pulmonary lesions. We evaluated the long-term results of lung metastasectomy for ACC in order to identify factors that should be taken into account in selecting patients eligible for surgery and treatment planning. Read More

    Erratum to "Head and neck adenoid cystic carcinoma: A prospective multicenter REFCOR study of 95 cases" [Eur. Ann. Otorhinolaryngol. Head Neck Dis. 133 (1) (2016) 13-7].
    Eur Ann Otorhinolaryngol Head Neck Dis 2016 Dec 26;133(6):453. Epub 2016 Oct 26.
    Service ORL-CCF, hôpital Tenon, université Paris VI, AP-HP, 4, rue de la Chine, 75020 Paris, France. Electronic address:

    Knockdown of SKA1 gene inhibits cell proliferation and metastasis in human adenoid cystic carcinoma.
    Biomed Pharmacother 2017 Jun 21;90:8-14. Epub 2017 Mar 21.
    School of Stomatology, Shandong University, Jinan, Shandong, 250100, China; Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng, Shandong, 252000, China. Electronic address:
    The spindle and kinetochore-associated complex subunit 1(SKA1) is a newly discovered gene, which has been associated with mitosis and tumorigenesis. However, its role insalivary adenoid cystic carcinoma (SACC) is still unknown, and the invasive and metastatic mechanism in SACC is still unclear. To explore the molecular mechanism of SKA1 in the process of malignant proliferation and metastasis in adenoid cystic cancer (ACC) cells, we employed lentivirus-mediated short hairpin RNA to knockdown SKA1 in SACC-83 cells. Read More

    AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.
    Am J Transl Res 2017 15;9(2):507-519. Epub 2017 Feb 15.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral BiomedicineMinistry of Education; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan UniversityWuhan, China.
    Salivary adenoid cystic carcinoma (AdCC) is a common head and neck cancer with the propensity for local spread and distant metastasis. In our previous study, elevated expression of Anterior gradient 2 (AGR2) was detected in head and neck squamous cell carcinoma (HNSCC), associated with epithelial-mesenchymal transition (EMT) and cancer stemness. However, to date, the expression and function of AGR2 in AdCC has yet to be elucidated. Read More

    Adenoid Cystic Carcinoma of Trachea.
    Indian J Surg 2017 Feb 13;79(1):67-69. Epub 2016 Feb 13.
    Queen Elizabeth University Teaching Hospital, Birmingham, UK.
    Adenoid cystic carcinoma (ACC) is the second most common primary malignant tumor of the trachea, after squamous cell carcinoma. Patients present with upper airway obstructive symptoms and signs including dyspnoea, cough, haemoptysis, and stridor which are often insidious, delaying diagnosis and optimal management. Described here is an unusual case of primary ACC cervical trachea with concomitant micropapillary thyroid carcinoma (microPTC) in a middle-aged lady presenting with cough and breathing difficulty since 3 months. Read More

    GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms.
    Am J Dermatopathol 2017 Apr;39(4):279-286
    *Departments of Pathology, Porto Medical School and Sao Joao Hospital, Porto, Portugal; †Departments of Pathology, William Beaumont School of Medicine, Royal Oak, MI; ‡Departments of Pathology, Duke University Medical Center, Durham, NC; and §Departments of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
    Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms. Read More

    Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation.
    Laryngoscope 2017 Mar 21. Epub 2017 Mar 21.
    Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
    Objectives: To report long-term local control in patients with adenoid cystic cancer (ACC) of the head and neck managed by surgery and identify factors predictive for local failure.

    Study Design: Single-institution retrospective cohort study.

    Methods: Eighty-seven patients who had surgery for ACC between 1985 and 2009 were identified. Read More

    [Analysis of BNIP3 expression and clinical research in salivary adenoid cystic carcinoma].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):404-407
    Dept. of Oral and Maxillofacial Surgery, Shandong Provincial Hos-pital Affiliated to Shandong University, Jinan 250021, China.
    Objective: This study investigated the expression of BNIP3 in salivary adenoid cystic carcinoma (SACC) and its correlations to the clinicopathological features and prognosis of patients with SACC. The role of BNIP3 in the progress of hypoxia-induced autophagy was elucidated.

    Methods: The expression levels of BNIP3, hypoxia inducible factor (HIF)-1α, and LC3 in 65 SACC cases were detected by immunohistochemical staining method, and the correlation between the expression of BNIP3 and the clinicopathological features in SACC was analyzed. Read More

    Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands.
    Eur Arch Otorhinolaryngol 2017 Jun 16;274(6):2549-2556. Epub 2017 Mar 16.
    Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
    This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody. Read More

    Study of Selected BRCA1, BRCA2, and PIK3CA Mutations in Benign and Malignant Lesions of Anogenital Mammary-Like Glands.
    Am J Dermatopathol 2017 May;39(5):358-362
    *Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia; Departments of §Pathology, and ¶Tumor Growth Biology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; ‖Department of Medical Genetics, Saint Petersburg Pediatric Medical University, Saint Petersburg, Russia; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Bioptical Laboratory, Pilsen, Czech Republic.
    Anogenital mammary-like glands (AGMLGs) are nowadays considered a normal component of the anogenital area. Lesions involving AGMLGs are histopathologically very similar to their mammary counterparts, but the information on molecular biological mechanisms in these vulvar/perianal tumors is scarce. Mutations in the PI3K-AKT cascade have been found in hidradenoma papilliferum. Read More

    Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells.
    Oncol Res 2017 Jan;25(2):207-214
    Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, P.R. China.
    Previous studies have shown that miR-222 targets the p53 upregulated modulator of apoptosis (PUMA) to regulate cell biological behavior in some human malignancies. We hypothesized that there was a negative regulation, which might induce apoptosis, between miR-222 and PUMA in adenoid cystic carcinoma (ACC). In this study, the expression levels of miR-222 and the PUMA gene after transfection with antisense miR-222 (As-miR-222) were evaluated by RT-PCR and Western blot assays. Read More

    Postoperative Radiotherapy in Salivary Gland Carcinoma: A Single Institution Experience.
    Gulf J Oncolog 2017 Jan;1(23):26-32
    Department of Otolaryngology, School of Medicine, Inonu University, Malatya, Turkey.
    Background: Salivary gland carcinoma are rare tumors and the main treatment is surgical. The addition of radiotherapy to surgery decreases locoregional relapses in high risk patients. Aim of our study is to retrospectively evaluate local control and survival and the factors affecting them in patients who received postoperative radiotherapy. Read More

    Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: An international collaborative study.
    Head Neck 2017 May 2;39(5):1008-1014. Epub 2017 Mar 2.
    The Head and Neck Center, Department of Otolaryngology - Head and Neck Surgery, Rambam Medical Center, Haifa, Israel.
    Background: The mainstay of treatment in adenoid cystic carcinoma (ACC) of the head and neck is surgical resection with negative margins. The purpose of this study was to define the margin status that associates with survival outcomes of ACC of the head and neck.

    Methods: We conducted univariate and multivariate analyses of international data. Read More

    Systemic therapy in metastatic salivary gland carcinomas: A pathology-driven paradigm?
    Oral Oncol 2017 Mar 19;66:58-63. Epub 2017 Jan 19.
    Medical Oncology Unit 3, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; University of Milan, Italy. Electronic address:
    Salivary gland carcinomas (SGCs) represent one of the most complex tumors from a pathological point of view. According to the World Health Organization (WHO) classification (2005), twenty-four malignant histotypes are recognized, almost all characterized by specific morphological and genetic features as well as by particular clinical behavior. Loco-regional relapse and distant metastases are quite common. Read More

    Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Nasal Cavity, Paranasal Sinuses and Skull Base.
    Head Neck Pathol 2017 Mar 28;11(1):3-15. Epub 2017 Feb 28.
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
    The sinonasal tract remains an epicenter of a diverse array of neoplasia. This paper discusses changes to the WHO classification system of tumors involving this area. In particular, seromucinous hamartoma, NUT carcinoma, biphenotypic sinonasal sarcoma, HPV-related carcinoma with adenoid cystic features, SMARCB1-deficient carcinoma, and renal cell-like adenocarcinoma are discussed. Read More

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