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    Adenoid cystic carcinoma of the head and neck area: Oncologic treatment and plastic-reconstructive options.
    Ear Nose Throat J 2017 Jun;96(6):E37-E40
    Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Ulm, Frauensteige 12, 89070 Ulm, Germany.
    Adenoid cystic carcinoma of the head and neck area is a rare malignant tumor with acceptable short-term but mediocre long-term prognosis. Radical tumor excision with clear resection margins, and sometimes resection of the facial nerve due to perineural growth, remains the fundamental therapy. We present 3 distinct clinical cases and discuss the current therapeutic options with special focus on plastic-reconstructive techniques. Read More

    [Anogenital mammary-like glands and related diseases. Part 2. Malignant tumors of the anogenital glands].
    Arkh Patol 2017 ;79(3):47-52
    Department of Pathology, Charles University, Plzen, Czech Republic.
    Mammary-like glands are a normal anatomical component of the anogenital region and can give rise to many benign and malignant tumors that morphologically mimic the similar diseases of the breast. The literature review is complemented by a description of 199 cases of malignant tumors of mammary-like glands. The paper presents the clinical and morphological characteristics of various malignant tumors of mammary-like glands, including extramammary Paget's disease, ductal, tubulolobular, adenoid cystic adenocarcinoma, low-grade phyllodes tumor, etc. Read More

    Mithramycin inhibits epithelial-to-mesenchymal transition and invasion by downregulating SP1 and SNAI1 in salivary adenoid cystic carcinoma.
    Tumour Biol 2017 Jun;39(6):1010428317708697
    Department of Stomatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
    Mithramycin exhibits certain anticancer effects in glioma, metastatic cerebral carcinoma, malignant lymphoma, chorionic carcinoma and breast cancer. However, its effects on salivary adenoid cystic carcinoma remain unclear. Here, we report that mithramycin significantly inhibited epithelial-to-mesenchymal transition and invasion in human salivary adenoid cystic carcinoma cell lines. Read More

    [Distant metastases of malignant salivary gland carcinoma after treated by (125)I].
    • Authors:
    Beijing Da Xue Xue Bao 2017 Jun;49(3):547-580
    Objective: To investigate clinical features of distant metastases from malignant salivary gland carcinomas after treated by (125)I internal brachy therapy alone.

    Methods: Between 2002 and 2010, 43 patients with locally advanced unresectable or recurrent malignant salivary gland carcinomas were treated by (125)I internal brachy therapy alone at Peking University School and Hospital of Stomatology. All of them had been follow-up at least 2 years. Read More

    A rare case of late solitary vertebral metastasis from an adenoid cystic carcinoma of the lacrimal gland.
    BMJ Case Rep 2017 Jun 13;2017. Epub 2017 Jun 13.
    Department of Neuropathology, Southampton University Hospitals NHS Trust, Southampton, UK.
    Adenoid cystic carcinoma of the lacrimal gland is one among the common malignancies affecting the lacrimal gland. However, overall, it is a rare condition. It has a rather poor prognosis with local recurrence and distant haematological metastasis which are invariably multiple. Read More

    Histologic and immunohistochemical identification of cribriform adenocarcinoma.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Jul 4;124(1):45-51. Epub 2017 Apr 4.
    Section of Oral Pathology - NewYork-Presbyterian/Queens and Chief, Section of Oral Pathology and Oral Medicine - The New York Presbyterian Hospital/Weill Medical College of Cornell University. Director, Oral Pathology Laboratory, Inc. in Flushing, NY and Assistant Director, Department of Dental and Oral Medicine - NewYork-Presbyterian/Queens Associate Professor of Surgery, Oral Medicine and Oral Pathology - Weill Cornell Medical College. Private practice of Clinical Oral Pathology and Oral Medicine at The New York Presbyterian Hospital/Weill Medical College of Cornell University, Flushing, NY.
    Objective: To assess whether tumors originally classified as adenocarcinoma not otherwise specified (Adca-NOS), adenoid cystic carcinoma (ACC), and polymorphous low-grade adenocarcinoma (PLGA) could be reclassified as cribriform adenocarcinoma of the tongue and minor salivary gland (CATMSG).

    Study Design: Tumors diagnosed between 1992 and 2014 at Oral Pathology Laboratory, Inc. (New York Presbyterian Hospital) were selected. Read More

    Transoral Robotic Surgery Total Laryngectomy: Evaluation of Functional and Survival Outcomes in a Retrospective Case Series at a Single Institution.
    ORL J Otorhinolaryngol Relat Spec 2017 Jun 14;79(4):191-201. Epub 2017 Jun 14.
    Department of Otolaryngology, Head and Neck Surgery, Royal Adelaide Hospital, Adelaide, SA, Australia.
    Background: Transoral robotic surgery total laryngectomy (TORS-TL) is a minimally invasive endoscopic surgical approach which can theoretically minimise the morbidity of large external incisions and limit dissection of tissue planes so as to reduce the risk of pharyngocutaneous fistulae related to poor tissue healing secondary to radiation soft tissue injury or malnutrition. The purpose of this paper was to report our experience with this uncommon surgical approach.

    Methods: A retrospective chart review was conducted at a single institution to evaluate the functional and survival outcomes of a series of patients who underwent TORS-TL. Read More

    Is axillary surgery beneficial for patients with adenoid cystic carcinoma of the breast?
    J Surg Oncol 2017 Jun 12. Epub 2017 Jun 12.
    Department of Surgery, Mayo Clinic, Rochester, Minnesota.
    Background And Objectives: Adenoid cystic carcinoma (ACC) is a rare, typically triple-negative, breast cancer reported to have a favorable prognosis and low rate of nodal metastasis. No consensus guidelines exist for axillary staging and treatment.

    Methods: We identified all patients with ACC evaluated at our institution from January 1994 to August 2016. Read More

    Early stage minor salivary gland adenoid cystic carcinoma has favourable prognosis.
    Virchows Arch 2017 Jun 10. Epub 2017 Jun 10.
    Department of Otorhinolaryngology - Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
    The purpose of the study was to evaluate the long-term outcome of minor salivary and mucous gland (MiSG) adenoid cystic carcinoma (ACC) of the head and neck and to compare the results with earlier reports including our recently published series on major salivary gland (MaSG) ACC. The study comprised 68 MiSG ACCs operated during 1974-2012 at the Helsinki University Hospital, Helsinki, Finland. Medical records and histological samples were reviewed. Read More

    MYB, MYBL1, MYBL2, and NFIB Gene Alterations and MYC Overexpression in Salivary Gland Adenoid Cystic Carcinoma.
    Histopathology 2017 Jun 8. Epub 2017 Jun 8.
    Department of Pathology and Molecular Diagnostics, Graduate School of Medical Sciences, Nagoya City University, Nagoya, 467-8601, Japan.
    Aims: Adenoid cystic carcinoma (AdCC) is one of the most common salivary gland malignancies and the long-term prognosis is poor. In this study, we examined alterations of AdCC-associated genes, MYB, MYBL1, MYBL2, and NFIB, and their target molecules including MYC. The results were correlated to clinicopathological profile of the patients. Read More

    Prostate-specific membrane antigen PET imaging and immunohistochemistry in adenoid cystic carcinoma-a preliminary analysis.
    Eur J Nucl Med Mol Imaging 2017 Jun 7. Epub 2017 Jun 7.
    Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands.
    Background: Adenoid cystic carcinoma (AdCC) of the head and neck is an uncommon malignant epithelial tumour of the secretory glands. Many patients develop slowly growing local recurrence and/or distant metastasis, for which treatment options are limited. A retrospective analysis of 9 AdCC patients was conducted to analyse the visualization of AdCC on PSMA PET/CT and to investigate the expression of PSMA on primary, recurrent and metastatic AdCC tumour tissue using immunohistochemistry. Read More

    [Clinical analysis of therapeutic bronchoscopy for tracheal neoplasm].
    Zhonghua Jie He He Hu Xi Za Zhi 2017 Jun;40(6):435-439
    Department of Respiratory and Critical Care Medicine, Changhai Hospital Affiliated to the Second Military Medical University, Shanghai 200433, China.
    Objective: To analyze the clinical features in adults with tracheal neoplasm and to evaluate the efficacy of interventional bronchoscopic treatment. Methods: We retrospectively analyzed the clinical features of 43 adults undergoing therapeutic bronchoscopy for tracheal neoplasm diagnosed in Changhai Hospital affiliated to the Second Military Medical University from January 2004 to July 2014.The degree of stenosis, the grade of dyspnea, and Karnofsky performance status scale were evaluated before and after the last procedure. Read More

    miR-582-5p inhibits invasion and migration of salivary adenoid cystic carcinoma cells by targeting FOXC1.
    Jpn J Clin Oncol 2017 Jun 7:1-9. Epub 2017 Jun 7.
    Guangdong Provincial Key Laboratory of Malignant Tumor, Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China.
    Objective: Neurotropism of salivary adenoid cystic carcinoma (SACC) and pulmonary metastasis may lead to in treatment failure. miR-582-5p plays important roles in tumorigenesis, invasion and migration. Here, we aim to determine the effect of miR-582-5p and its role in SACC invasion and metastasis. Read More

    Clinicopathologic characteristics of KIT and protein kinase C-δ expression in adenoid cystic carcinoma: Comparison with chromophobe renal cell carcinoma and gastrointestinal stromal tumor.
    Histopathology 2017 May 31. Epub 2017 May 31.
    Department of Pathology, Yonsei University College of Medicine, Seoul, Republic of Korea.
    Aims: KIT overexpression is frequently observed in adenoid cystic carcinomas (AdCCs), chromophobe renal cell carcinomas (ChRCCs), and gastrointestinal stromal tumor (GISTs). Persistent KIT activation has been reported to be mediated by protein kinase C (PKC)-δ in a subset of colon cancers with wild-type KIT overexpression and by PKC-θ in GISTs with mutant KIT overexpression. To elucidate the clinical implications of PKC-δ and PKC-θ expression in KIT-expressing tumors, we investigated the expression of KIT, PKC-δ, and PKC-θ in AdCCs and ChRCCs in comparison to GISTs. Read More

    Clinical Outcomes and Prognostic Factors of Adenoid Cystic Carcinoma of the Head and Neck.
    Anticancer Res 2017 06;37(6):3045-3052
    Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, U.S.A.
    Background: Adenoid cystic carcinoma (ACC) is a salivary gland malignancy with unpredictable growth and poorly understood prognostic factors.

    Patients And Methods: A database search of patients treated at a single Institution was used to identify patients with histologically-confirmed ACC. Patient, tumor, and treatment characteristics were examined via review of medical records. Read More

    Margin Analysis: Malignant Salivary Gland Neoplasms of the Head and Neck.
    Oral Maxillofac Surg Clin North Am 2017 May 24. Epub 2017 May 24.
    Oncology/Microvascular Surgery, University of Maryland Dental School, University of Maryland Medical Center, Greenbaum Cancer Center, Suite 1401, 650, West Baltimore Street, Baltimore, MD 21201, USA.
    There are no established protocols for the optimum surgical margin required for salivary gland malignancies. Factors including histologic diagnosis and TNM stage have been shown to be important in prognosis and survival outcome and mandate special consideration of margin size. Salivary cancers are treated differently at different anatomic sites and different histologic types show a propensity for major or minor glands. Read More

    Adenoid Cystic Carcinoma of Vulva-11 Years' Single-Institution Experience.
    J Obstet Gynaecol India 2017 Jun 19;67(3):196-201. Epub 2016 Sep 19.
    Division of Surgical Oncology, Regional Cancer Centre, Thiruvananthapuram, Kerala India.
    Introduction: Adenoid cystic carcinoma of vulva (ACC-vulva) is an extremely rare entity with <100 cases reported in the literature so far.

    Objective: To study the clinical profile and outcome of ACC-vulva treated at a tertiary cancer care centre in South India.

    Methods: This is a retrospective, record-based study of histopathologically confirmed cases of ACC-vulva treated at our centre from January 2005 to March 2016. Read More

    BRD4 inhibition suppresses cell growth, migration and invasion of salivary adenoid cystic carcinoma.
    Biol Res 2017 May 25;50(1):19. Epub 2017 May 25.
    Department of Periodontology, School of Stomatology, Shandong University, 44-1 West Wen Hua Road, Jinan, 250012, Shandong, People's Republic of China.
    Background: Bromodomain-containing protein 4 (BRD4) inhibition is a new therapeutic strategy for many malignancies. In this study, we aimed to explore the effect of BRD4 inhibition by JQ1 on in vitro cell growth, migration and invasion of salivary adenoid cystic carcinoma (SACC).

    Methods: The human normal epithelial cells and SACC cells (ACC-LM and ACC-83) were treated with JQ1 at concentrations of 0, 0. Read More

    Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Diagnosed in the Foot: A Case Report.
    J Am Podiatr Med Assoc 2017 May 22. Epub 2017 May 22.
    § Trinitas Regional Medical Center Residency Director.
    Adenoid cystic carcinoma is a rare, slow-growing neoplasm. It is most commonly located in the salivary glands, affects people older than 55 years of age, and has a predilection for women. These lesions may recur locally but have shown low metastatic potential. Read More

    Can the onset of orbital cancer be the result of a prosthetic eye?
    Acta Otorhinolaryngol Ital 2017 May 22. Epub 2017 May 22.
    ENT Department, University "G. d'Annunzio" of Chieti-Pescara, Hospital "SS Annunziata",Chieti, Italy.
    Orbital exenteration is a disfiguring procedure performed for unresponsive orbital infections and control of recurrent benign tumours and malignancies arising from the eyelids (basal cell carcinoma, squamous cell carcinoma, conjunctival malignant melanoma), lachrymal glands (adenoid cystic carcinoma) or surrounding sinuses. In extremely rare cases the use of a prosthetic eye after enucleation can lead to anophthalmic socket tumours. We report the case of a 54-year-old man who had left eye enucleation due to recurring events of retinal detachment and who developed an invasive fast growing epidermoid carcinoma 30 years later. Read More

    Prognostic factors of adenoid cystic carcinoma of the head and neck in carbon-ion radiotherapy: The impact of histological subtypes.
    Radiother Oncol 2017 Jun 18;123(3):387-393. Epub 2017 May 18.
    Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
    Purpose: The aim of this study was to evaluate the effect of histological subtypes of head and neck adenoid cystic carcinoma (ACC) on the results of carbon-ion radiotherapy (CIRT).

    Material And Methods: Of the 113 patients with ACC who were treated with CIRT between December 2006 and July 2013, 100 patients with identified histological subtypes were enrolled in this study. CIRT at a total dose of 57. Read More

    MicroRNA-320a is downregulated in non-small cell lung cancer and suppresses tumor cell growth and invasion by directly targeting insulin-like growth factor 1 receptor.
    Oncol Lett 2017 May 14;13(5):3247-3252. Epub 2017 Mar 14.
    College of Life Sciences, Agricultural University of Hebei, Baoding, Hebei 071001, P.R. China.
    Accumulating evidence has demonstrated that microRNAs (miRs/miRNAs) are implicated in carcinogenesis and cancer progression, and can function as oncogenes or tumor suppressor genes in human cancer types. Previous profile studies of miRNA expression levels have revealed that miR-320a was downregulated in breast cancer, colon cancer, bladder cancer, glioblastoma and salivary adenoid cystic carcinoma. However, its expression level, potential functions and the mechanisms underlying its functions in non-small cell lung cancer (NSCLC) require further investigation. Read More

    Cutaneous Adenoid Cystic Carcinoma with Perineural Invasion Diagnosed in the Foot: A Case Report.
    J Am Podiatr Med Assoc 2017 May 17. Epub 2017 May 17.
    § Trinitas Regional Medical Center Residency Director.
    Adenoid cystic carcinoma is a rare, slow-growing neoplasm. It is most commonly located in the salivary glands, affects people older than 55 years of age, and has a predilection for women. These lesions may recur locally but have shown low metastatic potential. Read More

    Use of fluorescent in-situ hybridisation in salivary gland cytology: A powerful diagnostic tool.
    Cytopathology 2017 May 15. Epub 2017 May 15.
    Rangueil Medical School, Histology and Embryology, Toulouse III Paul Sabatier University, Toulouse Cedex, France.
    Objective: Salivary gland cytology is challenging because it includes a diversity of lesions and a wide spectra of tumours. Recently, it has been reported that many types of salivary gland tumours have specific molecular diagnostic signatures that could be identified by fluorescent in-situ hybridisation (FISH). The aim of the present study was to demonstrate the feasibility and efficiency of FISH on routine cytological salivary gland smears. Read More

    MYB fusions and CD markers as tools for authentication and purification of cancer stem cells from salivary adenoid cystic carcinoma.
    Stem Cell Res 2017 May 5;21:160-166. Epub 2017 May 5.
    Division of Otolaryngology, Department of Surgery, Yale School of Medicine, New Haven, CT, United States. Electronic address:
    Cancer stem cells (CSC) are considered the major cause of aggressive tumor behavior, recurrence, metastases, and resistance to radiation, making them an attractive therapeutic target. However, isolation of CSC from tumor tissue and their characterization are challenging due to uncertainty about their molecular markers and conditions for their propagation. Adenoid cystic carcinoma (ACC), which arises predominantly in the salivary glands, is a slow-growing but relentless tumor that frequently invades nerves and metastasizes. Read More

    MYB Labeling by Immunohistochemistry Is More Sensitive and Specific for Breast Adenoid Cystic Carcinoma than MYB Labeling by FISH.
    Am J Surg Pathol 2017 Jul;41(7):973-979
    Departments of *Pathology †Oncology, The Johns Hopkins Hospital, Baltimore, MD.
    Breast adenoid cystic carcinoma (ACC) is a primary breast carcinoma that, like salivary gland ACC, displays the t(6;9) translocation resulting in the MYB-NFIB gene fusion and immunopositivity for MYB by immunohistochemistry (IHC). However, it is not well established whether MYB immunoreactivity or rearrangement can be used to support a diagnosis of ACC in a malignant basaloid or benign cribriform breast lesion. Whole sections of primary breast ACC (n=11), collagenous spherulosis (CS; n=7), and microglandular adenosis (MGA; n=5) and tissue microarrays containing 16 basal-like, triple-negative breast carcinomas (TNBC) were labeled for MYB by IHC and underwent MYB fluorescence in situ hybridization using a break-apart probe. Read More

    Adenoid Cystic Carcinoma of the Larynx Presenting as a Thyroid Mass and Brief Literature Review.
    Acta Cytol 2017 11;61(3):237-241. Epub 2017 May 11.
    Department of Pathology, School of Veterinary Medicine, Shahrekord University, Shahrekord, Iran.
    Background: Adenoid cystic carcinoma (ACC) of the larynx and trachea is very rare.

    Case: A 45-year-old man with ACC of the larynx presenting as a thyroid mass is reported in this study. Physical examination revealed a large solid thyroid nodule in the left lobe without any lymphadenopathy. Read More

    Epigallocatechin gallate inhibits the growth of salivary adenoid cystic carcinoma cells via the EGFR/Erk signal transduction pathway and the mitochondria apoptosis pathway.
    Neoplasma 2017 May 9;64. Epub 2017 May 9.
    ACC is one of the most malignant tumors in salivary gland, and of poor prognosis. A critical role in ACC development and progression is played by EGFR family members including EGFR. EGCG, a low molecular weight polyphenol contained in green tea, has broad anticancer properties, but whether EGCG regulates activity of ACC is unknown. Read More

    Cytology of Primary Salivary Gland-Type Tumors of the Lower Respiratory Tract: Report of 15 Cases and Review of the Literature.
    Front Med (Lausanne) 2017 24;4:43. Epub 2017 Apr 24.
    Service of Clinical Pathology, Institute of Pathology, Lausanne University Hospital, Lausanne, Switzerland.
    Primary pulmonary salivary gland-type tumors are rare neoplasms arising from the seromucinous submucosal glands of the lower respiratory tract (LRT), the most common of which are mucoepidermoid carcinoma (MEC) and adenoid cystic carcinoma. They are morphologically indistinguishable from their salivary gland counterpart and recognizing them is a challenge, especially on cytological specimens. We analyzed 15 cases of histologically proven primary salivary gland tumors of the LRT to identify cytomorphological features and define potential diagnostic clues that might assist cytopathologists in the preoperative diagnosis of these neoplasias. Read More

    Metastatic Intracranial Adenoid Cystic Carcinoma with Unknown Primary: Case Report and Review of Literature.
    J Neurosci Rural Pract 2017 Apr-Jun;8(2):274-276
    Department of Neuropathology, National Institute of Mental Health and Neurosciences, Hosur Road, Bengaluru, Karnataka, India.
    Adenoid cystic carcinoma (ACC) is an epithelial malignancy comprising approximately 8-10% of all salivary gland tumors. Intracranial ACC without a known primary is an extremely rare pathobiological event. Only 13 cases have been reported in available literature. Read More

    Histopathological study of salivary gland tumors.
    J Oral Maxillofac Pathol 2017 Jan-Apr;21(1):46-50
    Department of Pathology, S Nijalingappa Medical College, Hanagal Shree Kumareshwar Hospital and Research Centre, Medical College and Hospital, Bagalkot, Karnataka, India.
    Context: The salivary glands are the site of origin of a wide variety of neoplasms and are also relatively uncommon. The histopathology of these tumors is said to be the most complex and diverse of any organ in the body. The incidence of salivary gland tumors (SGTs) is claimed to be influenced by geographical and racial factors. Read More

    Parotid adenoid cystic carcinoma: Retrospective single institute analysis.
    Am J Otolaryngol 2017 Mar 31. Epub 2017 Mar 31.
    Otorhinolaryngology-Head and Neck Surgery Unit, Department of Surgery and Translational Medicine, University of Florence, AOU-Careggi, Via Largo Palagi 1, 50134 Florence, Italy.
    Purpose: Adenoid cystic carcinoma (ACC) is a uncommon salivary malignant tumor. Our aim was to review our experience with parotid ACC, to identify clinical-pathological parameters predictive for outcome.

    Materials And Methods: We retrospectively reviewed 228 patients affected by parotid gland carcinomas surgically treated at our Institution. Read More

    Full Mouth Reconstruction of a Skeletal Class II Division 1 Patient with Adenoid Cystic Carcinoma Using an Interim Immediate Obturator and a Definitive Obturator.
    Case Rep Dent 2017 4;2017:5458617. Epub 2017 Apr 4.
    Dental Research Center, Department of Prosthodontics, Faculty of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
    A 61-year-old female patient with adenoid cystic carcinoma (ACC) of the right maxilla and Angle class II division 1 malocclusion had received a subtotal maxillectomy in right side and used a conventional clasp-retained obturator. After implants placement, a maxillary interim immediate obturator (IIO) and then a definitive obturator using six endosseous implants were fabricated. During one-year follow-up, the patient was completely satisfied. Read More

    BSND is a Novel Immunohistochemical Marker for Oncocytic Salivary Gland Tumors.
    Pathol Oncol Res 2017 May 3. Epub 2017 May 3.
    Department of Tumor Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi Ward, Hamamatsu, 431-3192, Japan.
    BSND protein, which is involved in chloride transport, is expressed in normal kidney and the inner ear and is known as an immunohistochemical marker for chromophobe renal cell carcinoma (RCC) and renal oncocytoma; however, other organs and tumor types exhibiting BSND expression have not yet been reported. In this study, we investigated the expression of BSND using data from the Cancer Genome Atlas (TCGA) database and by performing immunohistochemical analyses. As a result, we found that BSND was also expressed in the striated duct cells of normal salivary glands. Read More

    Adenoid cystic carcinoma of the breast, 20 years of experience in a single center with review of literature.
    Breast Cancer 2017 May 2. Epub 2017 May 2.
    Mount Sinai Medical Center, Department of Surgery, 4300 Alton Road, Miami Beach, FL, 33140, USA.
    Background: Adenoid cystic carcinoma (ACC) of the breast is a rare type of breast cancer, which presents inconsistencies in the optimal management strategy.

    Methods: A retrospective review of prospectively collected data, spanning the last 20 years, was performed using the cancer registry database at our institution.

    Results: Six patients were diagnosed with ACC of the breast, out of 5,813 total patients diagnosed with breast cancer (0. Read More

    Lung metastases from cutaneous adenoid cystic carcinoma 23 years after initial treatment.
    Respir Med Case Rep 2017 19;21:121-123. Epub 2017 Apr 19.
    Department of Respiratory Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-Ku, Tokyo, 113-8431, Japan.
    Cutaneous adenoid cystic carcinoma (CACC) is an extremely rare neoplasm of head and neck region, and is characterized by propensity for local recurrence and perineural invasion. Late distant metastases occur usually to lungs. Although patients with lung metastases from CACC cannot be cured, long-term survival may be possible due to its slow-growing malignancy. Read More

    Expression of cancer cell-derived IgG and extra domain A-containing fibronectin in salivary adenoid cystic carcinoma.
    Arch Oral Biol 2017 Apr 21;81:15-20. Epub 2017 Apr 21.
    Central Laboratory, Peking University School and Hospital of Stomatology, 22 South Zhongguancun Avenue, Haidian District, Beijing 100081, China. Electronic address:
    Objective: Cancer-IgG is a newly-discovered molecule, mainly derived from epithelial carcinoma cells and is significantly correlated with differentiation, metastasis, local invasion, and poor prognosis of many cancers. In our previous study we detected IgG expression in oral epithelial carcinoma, including salivary adenoid cystic carcinoma (SACC), using an IgG-specific commercial antibody. Here, we explored the correlation between cancer-IgG and clinicopathological features of SACC. Read More

    Resection of upper lip adenoid cystic carcinoma and reconstruction with reverse Yu flap: Report of three cases and a literature review.
    Mol Clin Oncol 2017 Mar 3;6(3):444-450. Epub 2017 Feb 3.
    Department of Oral and Maxillofacial Surgery, Virgen Del Rocio University Hospital, 41013 Seville, Spain.
    The present study aimed to describe the techniques that were used, and the results obtained, with the reverse Yu flap to reconstruct medium-sized upper lip defects following resection for adenoid cystic carcinoma (ACC). Data concerning the clinical and pathological characteristics of tumours, the size and location of the defects, surgical resection and the reconstructive procedure used were evaluated in three patients, as well as postoperative complications and outcomes. In all cases, a complete surgical removal of ACC was achieved with clear margins of at least 1 cm. Read More

    New tumor entities in the 4th edition of the World Health Organization classification of head and neck tumors: Nasal cavity, paranasal sinuses and skull base.
    Virchows Arch 2017 Apr 25. Epub 2017 Apr 25.
    Section of Pathological Anatomy, Department of Surgery and Translational Medicine, University of Florence, Largo Brambilla 3, 50134, Florence, Italy.
    The World Health Organization recently published the 4th edition of the Classification of Head and Neck Tumors, including several new entities, emerging entities, and significant updates to the classification and characterization of tumor and tumor-like lesions, specifically as it relates to nasal cavity, paranasal sinuses, and skull base in this overview. Of note, three new entities (NUT carcinoma, seromucinous hamartoma, biphenotypic sinonasal sarcoma,) were added to this section, while emerging entities (SMARCB1-deficient carcinoma and HPV-related carcinoma with adenoid cystic-like features) and several tumor-like entities (respiratory epithelial adenomatoid hamartoma, chondromesenchymal hamartoma) were included as provisional diagnoses or discussed in the setting of the differential diagnosis. The sinonasal tract houses a significant diversity of entities, but interestingly, the total number of entities has been significantly reduced by excluding tumor types if they did not occur exclusively or predominantly at this site or if they are discussed in detail elsewhere in the book. Read More

    Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.
    Stem Cell Res 2017 May 8;21:94-105. Epub 2017 Apr 8.
    Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

    Model to Predict Cause-Specific Mortality in Patients with Head and Neck Adenoid Cystic Carcinoma: A Competing Risk Analysis.
    Ann Surg Oncol 2017 Apr 19. Epub 2017 Apr 19.
    Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, 157-8535, Japan.
    Purpose: The main objective of this study was to evaluate the cumulative incidence of cause-specific death and other causes of death for patients with head and neck adenoid cystic carcinoma (ACC). The secondary aim was to model the probability of cause-specific death and build a competing risk nomogram to predict cause-specific mortality for this disease.

    Methods: Data were extracted from the US National Cancer Institute's Surveillance Epidemiology, and End Results (SEER)-18 dataset. Read More

    A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma.
    Oncotarget 2017 May;8(20):32918-32929
    Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
    Purpose: Vorinostat is a histone deacetylase inhibitor (HDACi). Based on a confirmed partial response (PR) in an adenoid cystic carcinoma (ACC) patient treated with vorinostat in a prior phase 1 trial, we initiated this phase 2 trial.

    Methods: Vorinostat was administered orally 400 mg daily, 28 day cycles. Read More

    An Update on Tumors of the Lacrimal Gland.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172
    Department of Pathology, Rigshospitalet, University of Copenhagen, Cophenhagen, Denmark.
    Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to high-grade carcinomas, lymphomas, and sarcomas with large differences in prognosis and clinical management. The symptoms and findings of a lacrimal gland lesion are a growing mass at the site of the lacrimal gland, including displacement of the eyeball, decreased motility, diplopia, and ptosis. Pain is the cardinal symptom of an adenoid cystic carcinoma. Read More

    Surgical management of lung metastases.
    Br J Hosp Med (Lond) 2017 Apr;78(4):192-198
    Consultant Thoracic Surgeon, Thoracic Surgery Department, University College London Hospitals, London.
    Management of pulmonary metastases has evolved considerably over the last few decades but is still controversial. The surgical management of lung metastases is outlined, discussing the preoperative management, indications for surgery, the surgical approach and outcomes according to the primary histology. Read More

    Perineural spread-susceptible structures: a non-pathological evaluation of the skull base.
    Eur Arch Otorhinolaryngol 2017 Jul 7;274(7):2899-2905. Epub 2017 Apr 7.
    Department of Human Anatomy, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Ave. Madero y Calle Dr. Eduardo Aguirre Pequeño s/n, Colonia Mitras Centro, CP 64460, Monterrey, Nuevo Leon, Mexico.
    Perineural spread adenoid cystic carcinoma can alter the dimension of foramina and canals of the skull base. The objective of this study was to determine the range of normal variation of the foramina and canals of both hemicranium. We analyzed 200 individuals with no alterations of the skull base in a retrospective manner using high-resolution computed tomography. Read More

    B7-H3 regulates migration and invasion in salivary gland adenoid cystic carcinoma via the JAK2/STAT3 signaling pathway.
    Am J Transl Res 2017 15;9(3):1369-1380. Epub 2017 Mar 15.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan UniversityWuhan, China; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan UniversityWuhan, China.
    B7 Homolog 3 (B7-H3), a newly identified member of the B7 family, is over-expressed in various human cancers and plays a vital role in tumor progression. To identify the expression pattern of B7-H3 in human salivary adenoid cystic carcinoma (AdCC) and its underlying mechanisms, we characterized B7-H3 expression in AdCC tissue microarrays using immunohistochemical staining, and analyzed potentially associated molecules. The results showed that B7-H3 was highly expressed in salivary AdCC, compared with normal salivary glands. Read More

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