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    Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the milan system for reporting salivary gland cytopathology.
    Cancer Cytopathol 2018 Apr 18. Epub 2018 Apr 18.
    Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.
    Background: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. Read More

    The oncogenic effects of HES1 on salivary adenoid cystic carcinoma cell growth and metastasis.
    BMC Cancer 2018 Apr 17;18(1):436. Epub 2018 Apr 17.
    Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, 246 Yang Qiao Middle Road, Fuzhou, 350002, China.
    Background: Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. Read More

    Clinicopathologic analysis of 2736 salivary gland cases over a 11-year period in Southwest China.
    Acta Otolaryngol 2018 Apr 14:1-4. Epub 2018 Apr 14.
    a Department of Oral and Maxillofacial Surgery , Affiliated Stomatology Hospital of Kunming Medical University , Kunming , China.
    Objective: To investigate the epidemiological and clinicopathological characteristics of salivary gland tumors in southwest China in order to provide data for clinical diagnosis and other similar research.

    Methods: Between March 2007 and December 2017, 2736 patients with salivary gland tumors were recruited, the clinical and pathological data were retrospectively analyzed.

    Results: A total of 2736 patients had a ratio of males to females of about 1. Read More

    Cutaneous Adnexal Cylindroma of Breast: Epithelial Immunoreactivities for GATA-3, Mammaglobin, and E-Cadherin Do Not Equate to a Mammary Ductal Neoplasm.
    Case Rep Pathol 2018 13;2018:4039545. Epub 2018 Feb 13.
    RJ Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH, USA.
    Cylindromas are benign epithelial neoplasms derived from cutaneous eccrine adnexal structures. These tumors are most commonly encountered on the head, neck, and scalp of older women. In rare instances, solitary cylindromas may arise at other body sites. Read More

    [Bronchial adenoid cystic carcinoma masquerading as bronchial asthma: a case report].
    Beijing Da Xue Xue Bao Yi Xue Ban 2018 Apr;50(2):378-380
    Department of Respiratory Medicine, Peking University Third Hospital, Beijing 100191, China.
    Here we reported a case of bronchial adenoid cystic carcinoma from Peking University Third Hospital. A 40-year-old female presented with dry cough for 1 year and nocturnal paroxysmal attacks of wheezing for 4 months. She was a non-smoker, and did not have past histories of asthma or allergy. Read More

    Clinicopathological Behavior and Oncological Outcomes of Malignant Parotid Tumors in a Pakistani Population.
    Cureus 2018 Feb 5;10(2):e2157. Epub 2018 Feb 5.
    Radiation Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.
    Introduction The incidence of salivary gland tumors is influenced by geographical and racial factors resulting in diverse histology.  While salivary gland tumors account for a low proportion of head and neck cancers, most malignant tumors of the salivary gland are located in the parotid gland. The goals of this study are to describe the clinicopathological behavior of malignant parotid tumors and explore oncological outcomes related to survival in our Pakistani tertiary care cancer hospital. Read More

    Utility of Ber-EP4 and MOC-31 in Basaloid Skin Tumor Detection.
    Appl Immunohistochem Mol Morphol 2018 Apr 7. Epub 2018 Apr 7.
    Department of Pathology and Laboratory Medicine, University of Calgary, Calgary, AB, Canada.
    Ber-EP4 has been the traditional immunostain used for the detection of basaloid skin tumors. Recently, MOC-31 has shown be superior to Ber-EP4 in the detection of basosquamous basal cell carcinoma (BCC) and many centers are now using both Ber-EP4 and MOC-31 antibodies together to detect these lesions. The objective of this study was to compare the utility of using both Ber-EP4 and MOC-31 immunostains in the detection of basaloid skin tumors and to better characterize the previously unknown staining properties of MOC-31 in cutaneous lesions. Read More

    Pathology of Primary Tracheobronchial Malignancies Other than Adenoid Cystic Carcinomas.
    Thorac Surg Clin 2018 May;28(2):149-154
    Department of Surgery, St. Peter's Hospital, 315 New Scotland Avenue, Albany, NY 12208, USA.
    Most primary tracheal tumors are malignant. Malignancy of larynx and bronchi are much more likely than trachea. Tracheal tumors are most likely due to direct extension for surrounding tumors. Read More

    Biology of Adenoid Cystic Carcinoma of the Tracheobronchial Tree and Principles of Management.
    Thorac Surg Clin 2018 May;28(2):145-148
    Surgical Oncology, Division of Thoracic Surgery, Ottawa Hospital-General Division, University of Ottawa, 501 Smyth Road 6NW-6364, Ottawa, Ontario K1H 8L6, Canada. Electronic address:
    Adenoid cystic carcinoma of the trachea is a rare tumor. The mainstay of treatment remains surgical resection, even in the presence of positive margins or metastatic disease. Perineural involvement commonly causes positive margins and should not deter from resection. Read More

    Two cases of discrete adenoid pseudogland formation within benign intradermal melanocytic nevi.
    J Cutan Pathol 2018 Apr 6. Epub 2018 Apr 6.
    Department of Dermatology, San Antonio Military Medical Center, San Antonio, TX.
    We report two cases of benign intradermal melanocytic nevi with discrete glandular elements and mucin deposition engendering a diagnostic dilemma. The preliminary differential included entrapment of adnexal structures, collision with an adnexal neoplasm such as adenoid cystic carcinoma, or metastatic adenocarcinoma. A colloidal iron special stain confirmed the deposition of mucin, however a pankeratin AE1/AE3 immunohistochemical cocktail was surprisingly negative. Read More

    Imaging of Minor Salivary Glands.
    Neuroimaging Clin N Am 2018 May;28(2):295-302
    Department of Radiology, Michigan State University, Michigan State University Health Team, 846 Service Road, East Lansing, MI 48824, USA.
    Neoplastic and non-neoplastic lesions may involve the minor salivary glands. Tumors of minor salivary glands are commonly seen in the oral cavity. Malignant tumors are more common than benign minor salivary gland tumors. Read More

    Prognostic significance of 1p36 locus deletion in adenoid cystic carcinoma of the salivary glands.
    Virchows Arch 2018 Apr 4. Epub 2018 Apr 4.
    Department of Pathology, Faculty of Medicine in Plzen, Charles University, Plzen, Czech Republic.
    Adenoid cystic carcinoma (AdCC) of the salivary glands is characterized by MYB-NFIB or MYBL1-NFIB fusion, prolonged but relentlessly progressive clinical course with frequent recurrences, and development of distant metastasis resulting in high long-term mortality. Currently, no effective therapy is available for patients with advanced non-resectable and/or metastatic disease. Complicating the clinical management of this patient group is the lack of prognostic markers. Read More

    Bimodality treatment of patients with pelvic adenoid cystic carcinoma with photon intensity-modulated radiotherapy plus carbon ion boost: a case series.
    Cancer Manag Res 2018 26;10:583-588. Epub 2018 Mar 26.
    Department of Radiation Oncology, University Hospital of Heidelberg, Heidelberg, Germany.
    Background: Treatment of patients with pelvic adenoid cystic carcinoma (ACC) remains a challenge owing to the rarity of the disease, the lack of data, and the relative radioresistance of these tumors.

    Case Reports: This case series presents the results of three patients with recurrent or inoperable pelvic ACC treated with intensity-modulated radiotherapy (IMRT) plus carbon ion (C12) boost. Patients received C12 therapy at a dose of 3 Gray equivalents (GyE) (relative biological effectiveness [RBE]) per fraction up to 24 GyE RBE, followed by 50 GyE of photon IMRT in 25 fractions. Read More

    Lenvatinib-induced renal failure: two first-time case reports and review of literature.
    Expert Opin Drug Metab Toxicol 2018 Apr 13:1-7. Epub 2018 Apr 13.
    a Head and Neck Cancer Medical Oncology 3 Department , Fondazione IRCCS Istituto Nazionale dei Tumori , Milan , Italy.
    Introduction: Lenvatinib (LEN) is a multi-kinase anti-angiogenic drug recently approved in several cancers. LEN is not easily manageable due to its complex safety profile. Proteinuria and renal failure (RF) were reported among the most frequent LEN-induced adverse events (AEs), often leading to discontinuations or dose modifications. Read More

    Personalized oncogenomic analysis of metastatic adenoid cystic carcinoma: using whole-genome sequencing to inform clinical decision-making.
    Cold Spring Harb Mol Case Stud 2018 Apr 2;4(2). Epub 2018 Apr 2.
    British Columbia Cancer Agency, Division of Medical Oncology, Vancouver, British Columbia V5Z 4E6, Canada.
    Metastatic adenoid cystic carcinomas (ACCs) can cause significant morbidity and mortality. Because of their slow growth and relative rarity, there is limited evidence for systemic therapy regimens. Recently, molecular profiling studies have begun to reveal the genetic landscape of these poorly understood cancers, and new treatment possibilities are beginning to emerge. Read More

    The Efficacy of Touch Smear Cytology in the Diagnosis of Salivary Gland Cancers.
    J Oral Maxillofac Surg 2018 Mar 10. Epub 2018 Mar 10.
    Professor, Department of Otorhinolaryngology/Head & Neck Surgery, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Purpose: Methods for cytologic diagnosis, such as fine-needle aspiration (FNA) and touch smear (TS) cytology, have been frequently used for malignant tumor screening; however, false-negative cases often result in misdiagnosis. The purpose of this study was to investigate the causes of false-negative cases and methods to decrease the false-negative rate in salivary gland tumor TS cytology.

    Materials And Methods: In this cross-sectional study, the authors examined pathologically confirmed salivary gland tumors in 127 cases in which FNA and TS cytology were performed before the operation or open biopsy at Numazu City Hospital (Numazu, Japan) from 2002 to 2016. Read More

    3D-printing aided resection of intratracheal adenoid cystic carcinoma and mediastinal mature cystic teratoma in a 26-year-old female: a case report.
    J Thorac Dis 2018 Feb;10(2):E134-E137
    Department of Thoracic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
    Complete resection remains the ideal treatment for most patients with primary intratracheal tumors. Due to the limit in the resection length, the localization of the tumor during the surgery could be rather difficult if it hasn't invaded out of the trachea, which might be more difficult when there's another tumor in the anterior mediastinum. A 26-year-old woman with intratracheal adenoid cystic carcinoma (ACC) presented with dyspnea. Read More

    Histopathological Assessment for Esophageal Adenocarcinoma.
    Methods Mol Biol 2018 ;1756:67-76
    Cancer Molecular Pathology of School of Medicine, Griffith University, Gold Coast, Australia.
    In the World Health Organization (WHO) classification, adenocarcinoma of esophagus comprises preinvasive type (dysplasia), adenocarcinoma, adenoid cystic carcinoma, adenosquamous carcinoma, and mucoepidermoid carcinoma. For adenocarcinoma, it is important to determine the grading of the cancer and histological variants such as signet ring adenocarcinoma. In the current day management of esophageal adenocarcinoma by neoadjuvant therapy, the histology of the cancer and the lymph nodal status may change after the therapy. Read More

    Vanishing Parotid Tumors on MR Imaging.
    Yonago Acta Med 2018 Mar 28;61(1):33-39. Epub 2018 Mar 28.
    §Division of Radiology, Department of Pathophysiological and Therapeutic Science, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.
    Background: Of all parotid gland tumors, only oncocytoma has been reported to appear isointense to the parotid gland, namely vanishing, on fat-saturated T2 and T1 postcontrast gadolinium-enhanced magnetic resonance imaging (MRI). The purpose of this study was to evaluate vanishing of parotid tumors on conventional MRI with and/or without postcontrast gadolinium-enhancement and on diffusion weighted imaging (DWI).

    Methods: In 8 of 51 patients, ten parotid gland tumors had homogeneously enhanced lesions and were retrospectively analysed. Read More

    Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage.
    PLoS One 2018 29;13(3):e0194989. Epub 2018 Mar 29.
    Department of Otorhinolaryngology, Head and Neck Surgery, Heidelberg University Hospital, Heidelberg, Germany.
    Introduction: The transcription factor SOX2 has been identified as a lineage survival oncogene in squamous cell carcinoma and copy number gain is a common event in several human malignancies including head and neck cancer. However, the regulation and function of SOX2 during carcinogenesis as well as its prognostic value appears to be highly context dependent. As an example, high SOX2 expression in lung squamous cell carcinoma (SCC) is related to a favorable prognosis, while it is associated with poor outcome in lung adenocarcinoma. Read More

    Uptake of Prostate-Specific Membrane Antigen (PSMA) in adenoid cystic carcinoma - Is PSMA-PET-CT a helpful tool in radiation oncology?
    Clin Transl Radiat Oncol 2017 Dec 14;7:79-82. Epub 2017 Nov 14.
    Department of Nuclear Medicine, Heidelberg University Hospital, INF 400, 69120 Heidelberg, Germany.
    This case report shows the high PSMA-uptake in a patient with an adenoid cystic carcinoma of the maxillary sinus. Due to the intense ligand-uptake additional information for target volume delineation was obtained and the Treatment plan for bimodal radiotherapy with carbon ions was adapted accordingly. Read More

    The incidence of occult metastasis and the status of elective neck dissection in salivary adenoid cystic carcinoma: a single center study.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2018 Feb 2. Epub 2018 Feb 2.
    Department of Pathology, University of Göttingen, Göttingen, Germany.
    Objective: Adenoid cystic carcinoma (ACC) is characterized by a high rate of local recurrence and late distant metastasis. The status of an elective neck dissection (END) is controversial in the literature.

    Study Design: In this study we retrospectively analyzed the surgical treatment and follow-up examinations of 59 patients with ACCs of a salivary gland treated in a single center between 1980 and 2016. Read More

    TRAF6 mediated the promotion of Salivary Adenoid Cystic Carcinoma progression through Smad-p38-JNK signaling pathway induced by TGF-β.
    J Oral Pathol Med 2018 Mar 26. Epub 2018 Mar 26.
    Department of Oral and Maxillofacial Surgery, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
    Background: Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) has been proved to play an important role in tumorigenesis, invasion and metastasis. However, its precise role salivary adenoid cystic carcinoma (SACC) has not been determined. The aim of this study is to explore the role of TRAF6 in SACC including invasion and metastasis of SACC cells. Read More

    Assessment of CTNNB1 gene mutations and β-catenin immunoexpression in salivary gland pleomorphic adenomas and adenoid cystic carcinomas.
    Virchows Arch 2018 Mar 26. Epub 2018 Mar 26.
    Department of Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
    β-Catenin exerts multiple functions in several neoplasms, playing a major role in cell signaling and tumor progression. This study analyzed possible CTNNB1 mutations in salivary gland pleomorphic adenomas (PAs) and adenoid cystic carcinomas (ACCs), and determined possible differences in β-catenin immunoexpression in relation to these mutations, as well as histopathological aspects of these tumors. Twenty-four PAs (15 cell-rich and 9 cell-poor tumors) and 24 ACCs (10 tubular, 8 cribriform, and 6 solid tumors) were selected for the analysis of β-catenin distribution and cellular localization. Read More

    Choroidal metastasis of a minor salivary gland adenoid cystic carcinoma: A case report.
    Arch Soc Esp Oftalmol 2018 Mar 21. Epub 2018 Mar 21.
    Servicio de Oftalmología, Hospital Universitario de Burgos, Burgos, España.
    Case Report: A 61-year-old man with a lower lip minor salivary gland adenoid cystic carcinoma, suffered from a unilateral progressive visual acuity loss due to choroidal metastasis.

    Discussion: Adenoid cystic carcinoma is a rare primary tumour with significant metastatic potential. Our patient presented with a unilateral choroidal metastasis. Read More

    Small Subset of Adenoid Cystic Carcinoma of the Skin Is Associated With Alterations of the MYBL1 Gene Similar to Their Extracutaneous Counterparts.
    Am J Dermatopathol 2018 Mar 21. Epub 2018 Mar 21.
    Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic.
    Adenoid cystic carcinoma (ACC) of the skin is a rare malignant neoplasm histologically identical to homonymous tumors in other organs. Cutaneous ACC has been found to harbor MYB gene activations, either through MYB chromosomal abnormalities or by generation of the MYB-NFIB fusion. In salivary gland ACC, in addition to the MYB gene, alterations in MYBL1, the gene closely related to MYB, have been reported. Read More

    Inherited pulmonary cylindromas: Extending the phenotype of CYLD mutation carriers.
    Br J Dermatol 2018 Mar 22. Epub 2018 Mar 22.
    Department of Dermatology, Royal Victoria Infirmary Newcastle Upon Tyne.
    Background: Germline mutations in the tumour suppressor gene CYLD are recognised to be associated with the development of multiple cutaneous cylindromas. We encountered such a patient who presented with breathlessness due to multiple pulmonary cylindromas.

    Objective: Patients with rare genetic diseases are poorly studied, so we searched for clinical and radiological features of multiple pulmonary cylindromas in a cohort of 16 patients with CYLD mutations. Read More

    Secretory carcinoma of the parotid with adenoid cystic carcinoma cytological pattern: A cytological-pathological correlation with literature review.
    Ann Diagn Pathol 2018 Apr 24;33:58-61. Epub 2017 Dec 24.
    Medical College of Wisconsin, Department of Pathology, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, United States. Electronic address:
    Secretory carcinoma (SC) is a rare low-grade malignant tumor, defined by ETV6-NTRK3 fusion, identifiable by FISH. We describe a case in a 58-year-old male with a painless slowly growing 16mm palpable mass within left superficial parotid. FNA of the mass showed highly cellular specimen with moderate to large pleomorphic cells with round to ovoid nuclei with vesicular chromatin and distinct nucleoli. Read More

    Adenoid Cystic Carcinoma Metastasized to Colon.
    Cureus 2018 Jan 18;10(1):e2085. Epub 2018 Jan 18.
    Gastroenterology, Orlando VA Medical Center.
    Adenoid cystic carcinoma (ACC) is an infrequent cause of malignancy that accounts for 1% of all tumors of the oral and maxillofacial region. We present a 59-year-old woman with a past medical history of adenoid cystic carcinoma of the left salivary gland treated with radiation and thoracotomy due to lung metastasis. Years after the onset of diagnosis, she presented with nonspecific gastrointestinal symptoms. Read More

    Efficacy and safety of carbon-ion radiotherapy for lacrimal gland carcinomas with extraorbital extension: a retrospective cohort study.
    Oncotarget 2018 Feb 3;9(16):12932-12940. Epub 2018 Feb 3.
    Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
    Purpose: To evaluate the efficacy and safety of carbon-ion radiotherapy (CIRT) for patients with lacrimal gland carcinomas (LGCs) with extraorbital extension.

    Results: The median follow-up period was 53.7 months. Read More

    Detection of high PD-L1 expression in oral cancers by a novel monoclonal antibody LMab-4.
    Biochem Biophys Rep 2018 Mar 6;13:123-128. Epub 2018 Feb 6.
    Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.
    Programmed cell death-ligand 1 (PD-L1), which is a ligand of programmed cell death-1 (PD-1), is a type I transmembrane glycoprotein that is expressed on antigen-presenting cells and several tumor cells, including melanoma and lung cancer cells. There is a strong correlation between human PD-L1 (hPD-L1) expression on tumor cells and negative prognosis in cancer patients. In this study, we produced a novel anti-hPD-L1 monoclonal antibody (mAb), LMab-4 (IgG, kappa), using cell-based immunization and screening (CBIS) method and investigated hPD-L1 expression in oral cancers. Read More

    Salivary gland cancer patient-derived xenografts enable characterization of cancer stem cells and new gene fusions associated with tumor progression.
    Clin Cancer Res 2018 Mar 19. Epub 2018 Mar 19.
    University of Colorado at Denver, Anschutz Medical Campus
    Purpose: Salivary gland cancers (SGC) frequently present with distant metastases many years after diagnosis, suggesting a cancer stem cell (CSC) subpopulation that initiates late recurrences; however current models are limited both in their availability and suitability to characterize these rare cells.

    Experimental Design: Patient-derived xenografts (PDX) were generated by engrafting patient tissue onto nude mice from one acinic cell carcinoma (AciCC), four adenoid cystic carcinoma (ACC), and three mucoepidermoid carcinoma (MEC) cases, which were derived from successive relapses from the same MEC patient. Patient and PDX samples were analyzed by RNA-seq and Exome-seq. Read More

    The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma.
    J Oral Maxillofac Surg 2018 Feb 20. Epub 2018 Feb 20.
    Professor, State Key Laboratory of Military Stomatology, National Clinical Research Center for Oral Diseases, Shaanxi Clinical Research Center for Oral Diseases; and Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xi'an, China. Electronic address:
    Purpose: Perineural invasion (PNI) is a hallmark of salivary adenoid cystic carcinoma (SACC) and represents an important risk factor for local recurrence and poor survival. However, the mechanism of PNI has yet to be explored. We sought to examine the CCL5-CCR5 ligand-receptor interaction between nerves and SACC cells. Read More

    Polymorphous Sweat Gland Carcinoma: An Immunohistochemical and Molecular Study.
    Am J Dermatopathol 2018 Mar 6. Epub 2018 Mar 6.
    Department of Pathology, Medical College of Wisconsin, Milwaukee, WI.
    Polymorphous sweat gland carcinoma is an uncommon low-grade malignant adnexal tumor with a marked predilection for the distal extremities. Histologically, the lesions are characterized by a cellular proliferation showing a combination of growth patterns, including trabecular, solid, tubular, cribriform, or adenoid cystic and pseudopapillary. The immunohistochemical and molecular profile of these tumors has not yet been properly addressed. Read More

    Adenoid cystic carcinoma: focus on heavy ion therapy and molecular imaging.
    Am J Nucl Med Mol Imaging 2018 5;8(1):1-14. Epub 2018 Feb 5.
    Department of Nuclear Medicine, Humanitas Clinical and Research HospitalRozzano 20089, Italy.
    Surgery, radiation therapy and chemotherapy are the oldest modalities for cancer treatment. However, as part of a continuous research in medicine, in order to improve therapeutic precision and biological effectiveness, there is an increasing interest into the use of heavy particle (e.g. Read More

    Wnt/β-catenin signal alteration and its diagnostic utility in basal cell adenoma and histologically similar tumors of the salivary gland.
    Pathol Res Pract 2018 Apr 3;214(4):586-592. Epub 2018 Jan 3.
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka-shi, Fukuoka, 812-8582, Japan. Electronic address:
    Differential diagnosis among basal cell adenoma (BCA), basal cell adenocarcinoma (BCAC), adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) of the salivary gland can be challenging due to their similar histological appearance. Although frequent nuclear β-catenin expression and CTNNB1 mutations have been reported in BCA, further details of the Wnt/β-catenin signal alterations are unclear. The aim of this study was to assess the diagnostic utility of Wnt/β-catenin signal alteration in BCA and morphological mimics. Read More

    A retrospective multicenter study of carbon-ion radiotherapy for major salivary gland carcinomas: subanalysis of J-CROS 1402 HN.
    Cancer Sci 2018 Mar 1. Epub 2018 Mar 1.
    Hospital of the National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Sciences and Technology, Chiba, Japan.
    A retrospective multicenter study was conducted to assess the clinical outcomes of carbon-ion radiotherapy for head and neck malignancies (Japan Carbon-Ion Radiation Oncology Study Group [J-CROS] study: 1402 HN). We evaluated the safety and efficacy of carbon-ion radiotherapy in patients with major salivary gland carcinoma. Sixty-nine patients treated with carbon-ion radiotherapy at 4 Japanese institutions were analyzed. Read More

    Genomics of mucoepidermoid and adenoid cystic carcinomas.
    Laryngoscope Investig Otolaryngol 2018 Feb 8;3(1):56-61. Epub 2018 Feb 8.
    Section of Otolaryngology, Department of SurgeryUniversity of Chicago School of MedicineChicagoIllinois.
    Objective: To report on the current state of the literature on the genetics of mucoepidermoid and adenoid cystic carcinomas of the salivary glands with a focus on genomic screens and recently discovered genetic translocations.

    Methods: A PubMed based literature review was performed to query for genetics related basic science and preclinical studies about mucoepidermoid and adenoid cystic carcinomas of the salivary glands.

    Results And Conclusions: Genetic translocations between CRTC1 and MAML2 in mucoepidermoid carcinoma and between MYB and NFIB in adenoid cystic carcinoma have been recently discovered and have therapeutic implications. Read More

    Diagnostic utility of C-kit protein (CD117) expression in differentiating adenoid cystic carcinoma and polymorphous low grade Adenocarcinoma.
    Pak J Med Sci 2017 Nov-Dec;33(6):1376-1380
    Dr. Farhan Akhtar, FCPS. Assistant Professor Department of Histopathology, Armed Forces Institute of Pathology, PNS Shifa, Rawalpindi, Pakistan.
    Background & Objective: To evaluate usefulness of immunohistochemical marker C-kit (CD117) in differentiating Adenoid cystic carcinoma (AdCC) from Polymorphous low-grade adenocarcinoma (PLGA) in patients of salivary gland carcinomas. AdCC is a malignant salivary gland neoplasm with poor prognosis. PLGA is a salivary gland malignancy with indolent growth pattern. Read More

    Adenoid cystic carcinoma of palate: Report of a solid variant.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S65-S68
    Department of Oral Pathology and Microbiology, Government Dental College and Hospital, Aurangabad, Maharashtra, India.
    Adenoid cystic carcinomas (ADCCs) are uncommon tumors, comprising < 1% of all head-and-neck cancers and 20%-25% of all salivary cancers. The most common presenting symptom of the lesion is a slowly growing mass followed by pain due to the propensity of these tumors for perineural invasion. The tumor is most often clinically deceptive by its small size and slow growth, which actually overlies its extensive subclinical invasion and marked ability for early metastasis making the prognosis questionable, aptly referred as "wolf in sheep's clothing. Read More

    Adenoid cystic carcinoma of alveolar mucosa: A rare case report.
    J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S54-S56
    Department of Conservative Dentistry and Endodontics, Goa Dental College and Hospital, Bambolim, Goa, India.
    Adenoid cystic carcinomas are rare epithelial malignancies of salivary glands that show slow growth and local invasion with recurrences seen many years after diagnosis. Upto 50% of tumors occur in intraoral minor salivary glands usually in the hard palate. Tumors on the alveolar mucosa are extremely rare. Read More

    Primary Salivary Type Lung Cancers in the National Cancer Database.
    Ann Thorac Surg 2018 Feb 24. Epub 2018 Feb 24.
    Section of Thoracic Surgery, Department of Surgery, Yale School of Medicine, 330 Cedar St. BB205, PO Box 208062, New Haven, CT 06520-8062. Electronic address:
    Background: Primary Salivary Type Lung Cancers (PSTLC) such as Adenoid Cystic Carcinoma (ACC) and Mucoepidermoid Carcinoma (MEC) are uncommon primary lung tumors that given their rarity, remain incompletely understood. This study aimed to characterize the management and outcomes associated with these less common pulmonary malignancies.

    Methods: Patients in the National Cancer Database (NCDB) diagnosed with primary lung and bronchial (not tracheal) MEC and ACC between 2004-2014 were identified. Read More

    Transcriptomes define distinct subgroups of salivary gland adenoid cystic carcinoma with different driver mutations and outcomes.
    Oncotarget 2018 Jan 23;9(7):7341-7358. Epub 2017 Dec 23.
    Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM, USA.
    The relative rarity of salivary gland adenoid cystic carcinoma (ACC) and its slow growing yet aggressive nature has complicated the development of molecular markers for patient stratification. To analyze molecular differences linked to the protracted disease course of ACC and metastases that form 5 or more years after diagnosis, detailed RNA-sequencing (RNA-seq) analysis was performed on 68 ACC tumor samples, starting with archived, formalin-fixed paraffin-embedded (FFPE) samples up to 25 years old, so that clinical outcomes were available. A statistical peak-finding approach was used to classify the tumors that expressed or , which had overlapping gene expression signatures, from a group that expressed neither oncogene and displayed a unique phenotype. Read More

    Loss of PIM1 correlates with progression and prognosis of salivary adenoid cystic carcinoma (SACC).
    Cancer Cell Int 2018 20;18:22. Epub 2018 Feb 20.
    1Department of Head and Neck Surgery, Zhejiang Cancer Hospital, No. 38 Guangji Road, Hangzhou, 310022 Zhejiang China.
    Background: Increasing evidence indicates that PIM1 is a potential prognostic marker and target for cancer treatment but its precise mechanisms of action remain to be determined in salivary adenoid cystic carcinoma (SACC). This study aims to decipher the prognostic and mechanistic role of PIM1 in progression of SACC cells and tumor tissues.

    Methods: A SACC cell line (ACC-M) was transfected with shRNA plasmids targeting the PIM1 gene. Read More

    Adenoid cystic carcinomas of the salivary gland, lacrimal gland, and breast are morphologically and genetically similar but have distinct microRNA expression profiles.
    Mod Pathol 2018 Feb 21. Epub 2018 Feb 21.
    Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Denmark.
    Adenoid cystic carcinoma is among the most frequent malignancies in the salivary and lacrimal glands and has a grave prognosis characterized by frequent local recurrences, distant metastases, and tumor-related mortality. Conversely, adenoid cystic carcinoma of the breast is a rare type of triple-negative (estrogen and progesterone receptor, HER2) and basal-like carcinoma, which in contrast to other triple-negative and basal-like breast carcinomas has a very favorable prognosis. Irrespective of site, adenoid cystic carcinoma is characterized by gene fusions involving MYB, MYBL1, and NFIB, and the reason for the different clinical outcomes is unknown. Read More

    Radiation-Induced Painful Neurogenic Hypertrophy Treated With Botulinum Toxin A.
    J Clin Neuromuscul Dis 2018 Mar;19(3):135-137
    Neuromuscular Medicine, St. Luke's Rehabilitation Institute, Spokane, WA.
    Painful neurogenic hypertrophy is a rare complication of radiation therapy. We report a 27-year-old woman with a history of adenoid cystic carcinoma of the submandibular gland presented with painful twitching of her left shoulder. Electrodiagnostic studies were consistent with a diagnosis of radiation-induced spinal accessory nerve hyperactivity. Read More

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