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    Unlocking the chromatin of adenoid cystic carcinomas using HDAC inhibitors sensitize cancer stem cells to cisplatin and induces tumor senescence.
    Stem Cell Res 2017 Apr 8;21:94-105. Epub 2017 Apr 8.
    Laboratory of Epithelial Biology, Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, MI 48109-1078, USA; Comprehensive Cancer Center, University of Michigan, Ann Arbor, MI 48109, USA.

    Model to Predict Cause-Specific Mortality in Patients with Head and Neck Adenoid Cystic Carcinoma: A Competing Risk Analysis.
    Ann Surg Oncol 2017 Apr 19. Epub 2017 Apr 19.
    Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, 157-8535, Japan.
    Purpose: The main objective of this study was to evaluate the cumulative incidence of cause-specific death and other causes of death for patients with head and neck adenoid cystic carcinoma (ACC). The secondary aim was to model the probability of cause-specific death and build a competing risk nomogram to predict cause-specific mortality for this disease.

    Methods: Data were extracted from the US National Cancer Institute's Surveillance Epidemiology, and End Results (SEER)-18 dataset. Read More

    A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma.
    Oncotarget 2017 Mar 22. Epub 2017 Mar 22.
    Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA.
    Purpose: Vorinostat is a histone deacetylase inhibitor (HDACi). Based on a confirmed partial response (PR) in an adenoid cystic carcinoma (ACC) patient treated with vorinostat in a prior phase 1 trial, we initiated this phase 2 trial.

    Methods: Vorinostat was administered orally 400 mg daily, 28 day cycles. Read More

    An Update on Tumors of the Lacrimal Gland.
    Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):159-172
    Department of Pathology, Rigshospitalet, University of Copenhagen, Cophenhagen, Denmark.
    Lacrimal gland tumors are rare and constitute a wide spectrum of different entities ranging from benign epithelial and lymphoid lesions to high-grade carcinomas, lymphomas, and sarcomas with large differences in prognosis and clinical management. The symptoms and findings of a lacrimal gland lesion are a growing mass at the site of the lacrimal gland, including displacement of the eyeball, decreased motility, diplopia, and ptosis. Pain is the cardinal symptom of an adenoid cystic carcinoma. Read More

    Perineural spread-susceptible structures: a non-pathological evaluation of the skull base.
    Eur Arch Otorhinolaryngol 2017 Apr 7. Epub 2017 Apr 7.
    Department of Human Anatomy, Facultad de Medicina, Universidad Autonoma de Nuevo Leon, Ave. Madero y Calle Dr. Eduardo Aguirre Pequeño s/n, Colonia Mitras Centro, CP 64460, Monterrey, Nuevo Leon, Mexico.
    Perineural spread adenoid cystic carcinoma can alter the dimension of foramina and canals of the skull base. The objective of this study was to determine the range of normal variation of the foramina and canals of both hemicranium. We analyzed 200 individuals with no alterations of the skull base in a retrospective manner using high-resolution computed tomography. Read More

    B7-H3 regulates migration and invasion in salivary gland adenoid cystic carcinoma via the JAK2/STAT3 signaling pathway.
    Am J Transl Res 2017 15;9(3):1369-1380. Epub 2017 Mar 15.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral Biomedicine Ministry of Education, Wuhan UniversityWuhan, China; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan UniversityWuhan, China.
    B7 Homolog 3 (B7-H3), a newly identified member of the B7 family, is over-expressed in various human cancers and plays a vital role in tumor progression. To identify the expression pattern of B7-H3 in human salivary adenoid cystic carcinoma (AdCC) and its underlying mechanisms, we characterized B7-H3 expression in AdCC tissue microarrays using immunohistochemical staining, and analyzed potentially associated molecules. The results showed that B7-H3 was highly expressed in salivary AdCC, compared with normal salivary glands. Read More

    Down-regulation of miR-125a-5p is associated with salivary adenoid cystic carcinoma progression via targeting p38/JNK/ERK signal pathway.
    Am J Transl Res 2017 15;9(3):1101-1113. Epub 2017 Mar 15.
    Department of Oral and Maxillofacial Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen UniversityGuangzhou, China; Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangzhou Higher Education Institutes, Sun Yat-Sen UniversityGuangzhou, China.
    Salivary adenoid cystic carcinoma (SACC) is a relatively uncommon epithelial-like malignancy that can occur in the head and neck region. Despite its slow growth, this aggressive salivary gland tumor frequently recurs and metastasizes to distant organs since lacking effective chemotherapy treatment. MicroRNAs are key regulators in tumor metastasis and progression, but their roles during SACC progression have not been illustrated. Read More

    Breast adenoid cystic carcinoma: report of a case with emphasis on routine sonographic findings and shear wave elastography.
    J Med Ultrason (2001) 2017 Apr 5. Epub 2017 Apr 5.
    Department of Ultrasound, The First Affiliated Hospital of Zhejiang University, #79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
    Adenoid cystic carcinoma (ACC) of the breast is a rare malignant tumor. Its sonographic characteristics have been described in some reports, but there are few such reports available that describe the sonoelastographic findings of this tumor and provide additional information about the nature of the lesion. In this case report, we describe the routine sonographic findings and shear wave elastography findings of a breast adenoid cystic carcinoma in a 53-year-old woman. Read More

    A Phase II study of Dovitinib in Patients With Recurrent or Metastatic Adenoid Cystic Carcinoma.
    Clin Cancer Res 2017 Apr 4. Epub 2017 Apr 4.
    Medicine, Wake Forsest University.
    Purpose: Genetic and preclinical studies have implicated fibroblast growth factor receptor (FGFR) signaling in the pathogenesis of adenoid cystic carcinoma (ACC). Dovitinib, a suppressor FGFR activity, may be active in ACC.

    Methods: In a two-stage phase II study, 35 patients with progressive ACC were treated with dovitinib 500mg orally for 5 of 7 days continuously. Read More

    Sinonasal adenoid cystic carcinoma: Treatment outcomes and association with human papillomavirus.
    Head Neck 2017 Apr 3. Epub 2017 Apr 3.
    Department of Radiation Oncology, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio.
    Background: The purpose of this study was to review long-term outcomes of sinonasal adenoid cystic carcinoma (ACC) and to clarify its association with human papillomavirus (HPV).

    Methods: The medical records of 23 patients with sinonasal ACC treated with primary surgical resection between 1998 and 2013 were reviewed. Tissue specimens were available for 17 patients. Read More

    Expression of Cancer-Testis Antigens in Salivary Gland Carcinomas with Reference to MAGE-A and NY-ESO-1 Expression in Adenoid Cystic Carcinoma.
    Histopathology 2017 Mar 28. Epub 2017 Mar 28.
    Department of Pathology and Molecular Diagnostics, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.
    Background: Salivary gland carcinomas comprise a group of heterogeneous lesions with complex clinicopathological characteristics and distinct biological behaviors. However, recurrent or metastatic tumors are difficult to treat with currently available therapies. Cancer-testis antigens (CTAs) are detected in cancer cells but not in healthy normal tissues, with the exception of gametogenic tissues. Read More

    Analysis of orbital malignancies presenting in a tertiary care hospital in Pakistan.
    Pak J Med Sci 2017 Jan-Feb;33(1):70-74
    Dr. Sibghat-ul-Noor, MBBS. Institute of Ophthalmology/College of Ophthalmology and Allied Vision Sciences, King Edward Medical University, Mayo Hospital, Lahore, Pakistan.
    Objective: To determine the frequencies of various orbital malignancies amongst orbital lesions in patients presenting in a tertiary care hospital in Pakistan.

    Methods: A retrospective analysis of 666 orbital cases with an established histopathological diagnosis of malignant tumors treated in Mayo Hospital Lahore from 1996 to 2015 (20 years).

    Results: About 66% of the malignant tumors were primary, 25% secondary, 8% haematopoietic and 1% metastatic. Read More

    Adenoid Cystic Carcinoma of the Uterine Cervix: A Report of 2 Cases.
    Case Rep Pathol 2017 28;2017:8401741. Epub 2017 Feb 28.
    Department of Pathology, National Institute of Oncology, Rabat, Morocco.
    Adenoid cystic carcinoma is malignant tumor that exceptionally occurs in the uterine cervix. It is mostly seen in postmenopausal women and has an aggressive clinical course. We report two cases of an adenoid cystic carcinoma associated with a high grade squamous intraepithelial lesion and invasive squamous cell carcinoma of the uterine cervix and discuss briefly its clinical and pathological characteristics. Read More

    Submandibular salivary gland tumors: Clinical course and outcome of a 20-year multicenter study.
    Ear Nose Throat J 2017 Mar;96(3):E17-E20
    Department of Otorhinolaryngology-Head and Neck Surgery, Rabin Medical Center, Petah Tikva 49100, Israel.
    The purpose of this retrospective chart review study was to review the nature and clinical course of benign and malignant submandibular gland tumors at 2 major university-affiliated tertiary medical centers. All patients who underwent submandibular salivary gland excision between 1990 and 2010 were included. Clinical and disease-related data were collected from the medical charts. Read More

    Lung metastasectomy in adenoid cystic cancer: Is it worth it?
    Oral Oncol 2017 Feb 26;65:114-118. Epub 2016 Oct 26.
    Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milan, Italy; Thoracic Surgery Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
    Background And Purpose: Adenoid cystic carcinoma (ACC) of salivary glands is characterized by long-term distant metastasis, most commonly in lungs. No agreement has been reached about the role of surgical treatment of pulmonary lesions. We evaluated the long-term results of lung metastasectomy for ACC in order to identify factors that should be taken into account in selecting patients eligible for surgery and treatment planning. Read More

    Erratum to "Head and neck adenoid cystic carcinoma: A prospective multicenter REFCOR study of 95 cases" [Eur. Ann. Otorhinolaryngol. Head Neck Dis. 133 (1) (2016) 13-7].
    Eur Ann Otorhinolaryngol Head Neck Dis 2016 Dec 26;133(6):453. Epub 2016 Oct 26.
    Service ORL-CCF, hôpital Tenon, université Paris VI, AP-HP, 4, rue de la Chine, 75020 Paris, France. Electronic address:

    Knockdown of SKA1 gene inhibits cell proliferation and metastasis in human adenoid cystic carcinoma.
    Biomed Pharmacother 2017 Mar 21;90:8-14. Epub 2017 Mar 21.
    School of Stomatology, Shandong University, Jinan, Shandong, 250100, China; Liaocheng People's Hospital and Clinical School of Taishan Medical University, Liaocheng, Shandong, 252000, China. Electronic address:
    The spindle and kinetochore-associated complex subunit 1(SKA1) is a newly discovered gene, which has been associated with mitosis and tumorigenesis. However, its role insalivary adenoid cystic carcinoma (SACC) is still unknown, and the invasive and metastatic mechanism in SACC is still unclear. To explore the molecular mechanism of SKA1 in the process of malignant proliferation and metastasis in adenoid cystic cancer (ACC) cells, we employed lentivirus-mediated short hairpin RNA to knockdown SKA1 in SACC-83 cells. Read More

    AGR2 promotes the proliferation, migration and regulates epithelial-mesenchymal transition in salivary adenoid cystic carcinoma.
    Am J Transl Res 2017 15;9(2):507-519. Epub 2017 Feb 15.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology & Key Laboratory of Oral BiomedicineMinistry of Education; Department of Oral Maxillofacial-Head Neck Oncology, School and Hospital of Stomatology, Wuhan UniversityWuhan, China.
    Salivary adenoid cystic carcinoma (AdCC) is a common head and neck cancer with the propensity for local spread and distant metastasis. In our previous study, elevated expression of Anterior gradient 2 (AGR2) was detected in head and neck squamous cell carcinoma (HNSCC), associated with epithelial-mesenchymal transition (EMT) and cancer stemness. However, to date, the expression and function of AGR2 in AdCC has yet to be elucidated. Read More

    Adenoid Cystic Carcinoma of Trachea.
    Indian J Surg 2017 Feb 13;79(1):67-69. Epub 2016 Feb 13.
    Queen Elizabeth University Teaching Hospital, Birmingham, UK.
    Adenoid cystic carcinoma (ACC) is the second most common primary malignant tumor of the trachea, after squamous cell carcinoma. Patients present with upper airway obstructive symptoms and signs including dyspnoea, cough, haemoptysis, and stridor which are often insidious, delaying diagnosis and optimal management. Described here is an unusual case of primary ACC cervical trachea with concomitant micropapillary thyroid carcinoma (microPTC) in a middle-aged lady presenting with cough and breathing difficulty since 3 months. Read More

    GATA3 and MYB Expression in Cutaneous Adnexal Neoplasms.
    Am J Dermatopathol 2017 Apr;39(4):279-286
    *Departments of Pathology, Porto Medical School and Sao Joao Hospital, Porto, Portugal; †Departments of Pathology, William Beaumont School of Medicine, Royal Oak, MI; ‡Departments of Pathology, Duke University Medical Center, Durham, NC; and §Departments of Pathology, Harvard Medical School and Massachusetts General Hospital, Boston, MA.
    Knowledge of staining pattern of certain immunostains might be useful in the classification of cutaneous adnexal tumors that can have clinical importance. We studied GATA3 and MYB expression in archival materials of 220 adnexal tumors comprised of sebaceous carcinomas, follicular tumors, apocrine carcinoma, predominantly apocrine tumors, predominantly eccrine tumors, and others including adenoid cystic carcinomas. Nuclear GATA3 expression was seen in 70% (153/220) of cases, including sebaceous carcinoma (93%), apocrine carcinoma (93%), follicular neoplasms (100%), and predominantly apocrine neoplasms (69%), yet only 38% of predominantly eccrine neoplasms. Read More

    Long-term local control rates of patients with adenoid cystic carcinoma of the head and neck managed by surgery and postoperative radiation.
    Laryngoscope 2017 Mar 21. Epub 2017 Mar 21.
    Head and Neck Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, New York.
    Objectives: To report long-term local control in patients with adenoid cystic cancer (ACC) of the head and neck managed by surgery and identify factors predictive for local failure.

    Study Design: Single-institution retrospective cohort study.

    Methods: Eighty-seven patients who had surgery for ACC between 1985 and 2009 were identified. Read More

    [Analysis of BNIP3 expression and clinical research in salivary adenoid cystic carcinoma].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2016 Aug;34(4):404-407
    Dept. of Oral and Maxillofacial Surgery, Shandong Provincial Hos-pital Affiliated to Shandong University, Jinan 250021, China.
    Objective: This study investigated the expression of BNIP3 in salivary adenoid cystic carcinoma (SACC) and its correlations to the clinicopathological features and prognosis of patients with SACC. The role of BNIP3 in the progress of hypoxia-induced autophagy was elucidated.

    Methods: The expression levels of BNIP3, hypoxia inducible factor (HIF)-1α, and LC3 in 65 SACC cases were detected by immunohistochemical staining method, and the correlation between the expression of BNIP3 and the clinicopathological features in SACC was analyzed. Read More

    Immunoexpression of GLUT-1 and angiogenic index in pleomorphic adenomas, adenoid cystic carcinomas, and mucoepidermoid carcinomas of the salivary glands.
    Eur Arch Otorhinolaryngol 2017 Mar 16. Epub 2017 Mar 16.
    Postgraduate Program in Oral Pathology, Federal University of Rio Grande do Norte, Natal, RN, Brazil.
    This study aimed to evaluate and compare the immunoexpression of glucose transporter-1 (GLUT-1) and angiogenic index between pleomorphic adenomas (PAs), adenoid cystic carcinomas (ACCs), and mucoepidermoid carcinomas (MECs) of the salivary glands, and establish associations with the respective subtype/histological grade. Twenty PAs, 20 ACCs, and 10 MECs were submitted to morphological and immunohistochemical analysis. GLUT-1 expression was semi-quantitatively evaluated and angiogenic index was assessed by microvessel counts using anti-CD34 antibody. Read More

    Study of Selected BRCA1, BRCA2, and PIK3CA Mutations in Benign and Malignant Lesions of Anogenital Mammary-Like Glands.
    Am J Dermatopathol 2017 May;39(5):358-362
    *Department of Pathology, Clinical Research and Practical Center for Specialized Oncological Care, Saint Petersburg, Russia; †Department of Pathology, Medical Faculty, Saint-Petersburg State University, Saint-Petersburg, Russia; ‡Department of Pathology, Saint-Petersburg Medico-Social Institute, Saint Petersburg, Russia; Departments of §Pathology, and ¶Tumor Growth Biology, Petrov's Research Institute of Oncology, Saint Petersburg, Russia; ‖Department of Medical Genetics, Saint Petersburg Pediatric Medical University, Saint Petersburg, Russia; **Sikl's Department of Pathology, Medical Faculty in Pilsen, Charles University in Prague, Pilsen, Czech Republic; and ††Bioptical Laboratory, Pilsen, Czech Republic.
    Anogenital mammary-like glands (AGMLGs) are nowadays considered a normal component of the anogenital area. Lesions involving AGMLGs are histopathologically very similar to their mammary counterparts, but the information on molecular biological mechanisms in these vulvar/perianal tumors is scarce. Mutations in the PI3K-AKT cascade have been found in hidradenoma papilliferum. Read More

    Downregulation of miR-222 Induces Apoptosis and Cellular Migration in Adenoid Cystic Carcinoma Cells.
    Oncol Res 2017 Jan;25(2):207-214
    Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, P.R. China.
    Previous studies have shown that miR-222 targets the p53 upregulated modulator of apoptosis (PUMA) to regulate cell biological behavior in some human malignancies. We hypothesized that there was a negative regulation, which might induce apoptosis, between miR-222 and PUMA in adenoid cystic carcinoma (ACC). In this study, the expression levels of miR-222 and the PUMA gene after transfection with antisense miR-222 (As-miR-222) were evaluated by RT-PCR and Western blot assays. Read More

    Postoperative Radiotherapy in Salivary Gland Carcinoma: A Single Institution Experience.
    Gulf J Oncolog 2017 Jan;1(23):26-32
    Department of Otolaryngology, School of Medicine, Inonu University, Malatya, Turkey.
    Background: Salivary gland carcinoma are rare tumors and the main treatment is surgical. The addition of radiotherapy to surgery decreases locoregional relapses in high risk patients. Aim of our study is to retrospectively evaluate local control and survival and the factors affecting them in patients who received postoperative radiotherapy. Read More

    Defining the surgical margins of adenoid cystic carcinoma and their impact on outcome: An international collaborative study.
    Head Neck 2017 May 2;39(5):1008-1014. Epub 2017 Mar 2.
    The Head and Neck Center, Department of Otolaryngology - Head and Neck Surgery, Rambam Medical Center, Haifa, Israel.
    Background: The mainstay of treatment in adenoid cystic carcinoma (ACC) of the head and neck is surgical resection with negative margins. The purpose of this study was to define the margin status that associates with survival outcomes of ACC of the head and neck.

    Methods: We conducted univariate and multivariate analyses of international data. Read More

    Systemic therapy in metastatic salivary gland carcinomas: A pathology-driven paradigm?
    Oral Oncol 2017 Mar 19;66:58-63. Epub 2017 Jan 19.
    Medical Oncology Unit 3, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy; University of Milan, Italy. Electronic address:
    Salivary gland carcinomas (SGCs) represent one of the most complex tumors from a pathological point of view. According to the World Health Organization (WHO) classification (2005), twenty-four malignant histotypes are recognized, almost all characterized by specific morphological and genetic features as well as by particular clinical behavior. Loco-regional relapse and distant metastases are quite common. Read More

    Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Tumors of the Nasal Cavity, Paranasal Sinuses and Skull Base.
    Head Neck Pathol 2017 Mar 28;11(1):3-15. Epub 2017 Feb 28.
    Department of Pathology, Johns Hopkins University, Baltimore, MD, USA.
    The sinonasal tract remains an epicenter of a diverse array of neoplasia. This paper discusses changes to the WHO classification system of tumors involving this area. In particular, seromucinous hamartoma, NUT carcinoma, biphenotypic sinonasal sarcoma, HPV-related carcinoma with adenoid cystic features, SMARCB1-deficient carcinoma, and renal cell-like adenocarcinoma are discussed. Read More

    Two Different Cell Populations Is an Important Clue for Diagnosis of Primary Cutaneous Adenoid Cystic Carcinoma: Immunohistochemical Study.
    Case Rep Pathol 2017 24;2017:7949361. Epub 2017 Jan 24.
    Pathology Department, Abdurrahman Yurtaslan Oncology Education and Research Hospital, Ankara, Turkey.
    Primary cutaneous adenoid cystic carcinoma (PCACC) is a very rare malignancy. The differential diagnosis of PCACCs in pathology practice can be difficult and a group of primary and metastatic lesions, including adenoid basal cell carcinoma of the skin, should be considered in the differential diagnosis. Besides histomorphological clues, immunohistochemistry studies are very helpful in the differential diagnosis of PCACC. Read More

    Adenoid Cystic Carcinoma of Maxillary Sinus Misdiagnosed as Chronic Apical Periodontitis.
    J Oral Maxillofac Surg 2017 Feb 1. Epub 2017 Feb 1.
    Associate Professor, Department of Conservative Dentistry, Wonju Severance Christian Hospital, Yonsei University, Wonju, Republic of Korea. Electronic address:
    Sometimes pain originating from a non-odontogenic pathologic condition is mistaken as endodontic illness, leading to misdiagnosis. The patient can misinterpret the pain as originating from a site different from the actual site, which is known as referred pain. However, the clinician managing pain in the orofacial region needs to be well-informed about the typical signs and symptoms of non-odontogenic diseases and to be able to make the correct referral when necessary for proper diagnosis and treatment. Read More

    Association between high expression of phosphorylated Akt and mammalian target of rapamycin and improved survival in salivary gland adenoid cystic carcinoma.
    Head Neck 2017 Feb 23. Epub 2017 Feb 23.
    Department of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, China.
    Background: Previous genomic studies revealed phosphotidylinositol-3-kinase (PI3K)/Akt pathway mutation in human salivary gland adenoid cystic carcinoma (ACC). No validation of its prognostic value has been reported.

    Methods: P-Akt, pan-Akt, phosphorylated-mammalian target of rapamycin (p-mTOR), PI3K, and insulin-like growth factor-1 receptor beta (IGF-1Rβ) were detected on 120 salivary gland ACC/adjacent salivary gland pairs immunohistochemically and were correlated with clinicopathological data. Read More

    Biochemical changes of salivary gland adenoid cystic carcinoma cells induced by SGI-1776.
    Exp Cell Res 2017 Mar 20;352(2):403-411. Epub 2017 Feb 20.
    Zhejiang Cancer Research Institute, Zhejiang Province Cancer Hospital, Hangzhou 310022, China. Electronic address:
    Provirus integration site for Moloney murine leukemia virus 1 (Pim-1) has proved to be an oncogene and it is known that to depress Pim-1 activity may be a novel oncological treatment strategy. SGI-1776, a small molecule, is the first clinically tested inhibitor of the Pim kinase family. Here, we aimed to explore the effect of SGI-1776 on salivary adenoid cystic carcinoma (SACC). Read More

    How Phenotype Guides Management of the Most Common Malignant Salivary Neoplasms of the Larynx?
    Adv Ther 2017 Apr 21;34(4):813-825. Epub 2017 Feb 21.
    Coordinator of the International Head and Neck Scientific Group, Padua, Italy.
    Salivary gland carcinomas of the larynx are uncommon. Adenoid cystic carcinoma is the most prevalent type of salivary gland carcinoma in this region, although other histologies such as mucoepidermoid carcinoma and adenocarcinomas have been reported. These tumors may present with advanced-stage due to nonspecific symptoms and their relatively slow-growing nature. Read More

    Lymph node involvement predicts poor prognosis in primary tongue adenoid cystic carcinoma: A preliminary study of 54 cases.
    J Craniomaxillofac Surg 2017 Apr 25;45(4):589-594. Epub 2017 Jan 25.
    Department of Oral Maxillofacial-Head Neck Oncology, Faculty of Oral and Maxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology (Head: Pro. Chenping Zhang), 639 Zhizaoju Road, Luwan District, Shanghai 200011, PR China.
    Purpose: Primary tongue adenoid cystic carcinoma (ACC) is extremely rare. The relationship between the patient's prognosis and the tumor's clinicopathological characteristics is uncertain. The aim of this study was to identify the prognostic factors and analyze the overall outcomes for patients with tongue ACC. Read More

    36 cases adenoid cystic carcinoma of the breast in China: Comparison with matched grade one invasive ductal carcinoma-not otherwise specified.
    Pathol Res Pract 2017 Apr 31;213(4):310-315. Epub 2017 Jan 31.
    Department of Breast Oncology, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Key Laboratory of Cancer Prevention and Therapy, Tianjin,National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer, Tianjin Medical University Cancer Institute and Hospital, Huanhuxi Road, Tianjin 300060, China. Electronic address:
    Objective: The aim of this study was to investigate the clinicopathological characteristic of adenoid cystic carcinoma (ACC).

    Materials And Methods: The clininopathological features, along with relapse free survival(RFS) and overall survival(OS) of 36 patients with ACC were retrospectively investigated and compared with those of 108 grade 1 invasive ductal carcinoma not-otherwise-specified (G1-IDC-NOS) patients.

    Results: Most cases of ACC were ER, PR and HER-2 negative which was classified as triple-negative subtype. Read More

    Long-Term Outcomes of Eye-Sparing Surgery for Adenoid Cystic Carcinoma of Lacrimal Gland.
    Ophthal Plast Reconstr Surg 2017 Feb 17. Epub 2017 Feb 17.
    *Department of Ophthalmology, Myongji Hospital, Seonam University School of Medicine, Goyang, †Department of Ophthalmology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea; and ‡Department of Ophthalmology, UT Southwestern Medical Center, Dallas, Texas, U.S.A.
    Purpose: This study's primary purpose is to assess the long-term outcomes of patients who have undergone eye-sparing surgery and adjuvant radiotherapy for adenoid cystic carcinoma of the lacrimal gland.

    Methods: In this retrospective analysis, clinical records were reviewed of all patients diagnosed with adenoid cystic carcinoma of the lacrimal gland, at a single institution, between March 1998 and November 2012. Ten patients were identified as having undergone eye-sparing surgery and adjuvant radiotherapy for adenoid cystic carcinoma of the lacrimal gland. Read More

    Expression Profiling of Clinical Specimens Supports the Existence of Neural Progenitor-Like Stem Cells in Basal Breast Cancers.
    Clin Breast Cancer 2017 Jan 27. Epub 2017 Jan 27.
    Department of Surgery, Section of Otolaryngology, Yale School of Medicine, New Haven, CT. Electronic address:
    Background: We previously characterized in salivary adenoid cystic carcinoma (ACC) a novel population of cancer stem cells (CSCs) marked by coexpression of 2 stemness genes, sex-determining region Y (SRY)-related HMG box-containing factor 10 (SOX10) and CD133. We also reported that in ACC and basal-like breast carcinoma (BBC), a triple-negative breast cancer subtype, expression of SOX10 similarly demarcates a highly conserved gene signature enriched with neural stem cell genes. On the basis of these findings, we hypothesized that BBC might be likewise driven by SOX10-positive (SOX10(+))/CD133(+) cells with neural stem cell properties. Read More

    Genetic Characterization of Adenoid Cystic Carcinoma of the Minor Salivary Glands: A Potential Familial Occurrence in First-Degree Relatives.
    Head Neck Pathol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
    Adenoid cystic carcinoma (AdCC) is a malignant salivary gland tumor. To date, no cases of AdCC in first-degree relatives have been reported in the literature. We present a 50-year-old female (Case 1) and this patients' father (Case 2), both of whom were diagnosed with AdCC of the minor salivary glands. Read More

    Cytokeratin immunoprofile of primary and metastatic adenoid cystic carcinoma of salivary glands: a report of two cases.
    Autops Case Rep 2016 Oct-Dec;6(4):57-63. Epub 2016 Dec 30.
    Department of Stomatology - Dental School - Universidade de São Paulo, São Paulo/SP - Brazil .
    Distant metastases from salivary gland tumors are considered infrequent: the incidence of distant metastases ranges from 24% to 61% according to different histotypes and to the site of the primary mass. The most common site of distant metastases due to salivary gland malignancies is the lung. From the pathology point of view, cytokeratins (CK) are important differentiation markers in salivary gland tumors, which are often used for the diagnostic process. Read More

    Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis.
    Oncotarget 2017 Feb 11. Epub 2017 Feb 11.
    Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
    Adenoid cystic carcinoma of salivary glands is a rare adenocarcinoma and has been placed in "high-risk" category as poor long-term prognosis. The purpose of this study was to investigate p53 protein expression in adenoid cystic carcinoma of salivary glands and its correlation with clinicopathological parameters and prognosis. Literatures were searched from PubMed, Embase, Cochrane Library and Web of Science, which investigated the relationships between p53 expression and pathological type, clinical stage, local recurrence, metastasis, nerve infiltration and overall survival. Read More

    Cribriform adenocarcinoma of the minor salivary gland arising in the tonsil with metastasis to a cervical lymph node: A case report with description of fine needle aspiration cytology.
    Diagn Cytopathol 2017 May 16;45(5):468-471. Epub 2017 Feb 16.
    Department of Pathology, University of Kansas School of Medicine, Kansas City, Kansas, 66160.
    Cribriform adenocarcinoma of minor salivary gland (CAMSG) is a rare tumor of the head and neck. We report a case of a 70-year-old female who presented with a 4-5-month history of a left neck mass. CT scan of the neck showed a left neck mass just inferior to the angle of the mandible and left tonsillar prominence. Read More

    Patterns of care and survival of adjuvant radiation for major salivary adenoid cystic carcinoma.
    Laryngoscope 2017 Feb 14. Epub 2017 Feb 14.
    Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, New York.
    Objectives/hypothesis: National Cancer Care Network guidelines suggest consideration of adjuvant radiation even for early stage adenoid cystic carcinoma of the salivary glands. We used the National Cancer Data Base (NCDB) to analyze practice patterns and outcomes of postoperative radiotherapy for adenoid cystic carcinomas.

    Study Design: Retrospective NCDB review. Read More

    Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible: A Comprehensive Review With Analysis of 2 Additional Cases.
    J Oral Maxillofac Surg 2017 Jan 18. Epub 2017 Jan 18.
    Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
    Purpose: Primary intraosseous adenoid cystic carcinoma (IACC) of the mandible is poorly understood because of its rarity. This study performed a comprehensive literature review on IACC of the mandible.

    Materials And Methods: Forty-five cases of IACC reported in the literature and 2 additional cases in the authors' hospital were reviewed. Read More

    HIF1α in Tumorigenesis of Adenoid Cystic Carcinoma.
    Anticancer Res 2017 02;37(2):599-606
    Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
    Background: Tumor hypoxia induces hypoxia-inducible factor-1α (HIF1α), which can influence tumorigenesis and metastasis. We evaluated the expression of HIF1α and the effect of HIF1α inhibitors in adenoid cystic carcinoma (ACC).

    Materials And Methods: HIF1α expression was demonstrated in ACC cell lines (ACC2 and ACCM). Read More

    Adenoid cystic carcinoma of the base of tongue: A population-based study.
    Am J Otolaryngol 2017 Jan 18. Epub 2017 Jan 18.
    Department of Otolaryngology, Head & Neck and Skull Base Surgery, Boston Medical Center, Boston, MA, United States. Electronic address:
    Background: The objective was to assess demographic and survival patterns in patients with adenoid cystic carcinoma of the base of tongue.

    Methods: Patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1973 through 2012 and were categorized by age, gender, race, historical stage A, and treatment. Incidence and survival were compared with Kaplan Meier curves and mortality hazard ratios. Read More

    Endoscopy-Assisted Transoral Versus Endoscopy-Assisted Transcervical Minimal Incision Plus Mandibular Osteotomy Approach in Resection of Large Parapharyngeal Space Tumors.
    J Craniofac Surg 2017 Feb 6. Epub 2017 Feb 6.
    Department of Oral and Maxillofacial Surgery, Sun Yet-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
    Background: Resection of the parapharyngeal space is often challenging. This study aims to evaluate the outcome of the endoscopy-assisted transoral approach for resection of the parapharyngeal space tumors compared with the endoscopy-assisted transcervical approach.

    Methods: Twenty-three consecutive patients (15 males, 8 females) who underwent resection of large parapharyngeal space tumors via endoscopy-assisted transoral (ETO) approach or endoscopy-assisted transcervical minimal incision plus osteotomy of the vertical ramus outside the mandibular foramen (ETC + MO) approach were analyzed retrospectively. Read More

    Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma.
    Otolaryngol Head Neck Surg 2017 Apr 7;156(4):660-664. Epub 2017 Feb 7.
    1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California, USA.
    Objective To determine the risk of nodal metastasis, examine risk factors for nodal metastasis, and evaluate the impact of nodal metastasis on survival in patients with major salivary gland adenoid cystic carcinoma. Study Design Retrospective cohort study from a large population- based cancer database. Methods Data were extracted from the SEER 18 database (Surveillance, Epidemiology, and End Results) of the National Cancer Institute. Read More

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