8,262 results match your criteria Cylindroma

CD56 expression in basaloid anal squamous cell carcinoma - A potential diagnostic pitfall.

Ann Diagn Pathol 2021 May 8;53:151758. Epub 2021 May 8.

Department of Pathology, University of Massachusetts, UMass Memorial Medical Center, 1 Innovation Dr., Biotech 3 Bldg., 2nd Floor, Worcester, MA, USA. Electronic address:

Anal squamous cell carcinoma (SqCC) is a morphologically heterogeneous entity. Basaloid and non-keratinizing anal SqCC may be confused with other tumors including neuroendocrine carcinoma due to morphologic overlap, and expression of neuroendocrine markers is not well-studied in anal SqCC. Prompted by a case of anal SqCC that was initially misdiagnosed as neuroendocrine carcinoma on the basis of morphology and CD56 expression, we retrospectively examined the expression of neuroendocrine markers CD56, synaptophysin, and chromogranin in 48 cases of basaloid anal SqCC, with clinicopathologic correlation. Read More

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Basal Cell Carcinoma of Prostate With MSMB-NCOA4 Fusion and a Probable Basal Cell Carcinoma In Situ: Case Report.

Int J Surg Pathol 2021 May 12:10668969211017321. Epub 2021 May 12.

Department of Pathology, 572974Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.

Basal cell carcinomas of prostate (BCCP) are very rare. Most arise in the transition zone and thus are associated with lower urinary tract symptoms and rarely associated with elevated prostate-specific antigen (PSA). These features make diagnosis/early diagnosis difficult because of the routine protocols followed. Read More

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Expanding role of radiotherapy in adenoid cystic carcinoma of the tracheobronchial tree: a new horizon.

Tumori 2021 May 12:3008916211012461. Epub 2021 May 12.

Department of Radiotherapy and Oncology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India.

Background: Primary adenoid cystic carcinomas (ACCs) of central trachea-bronchi system are rare and heterogeneous tumors. Definitive radiotherapy (RT) is the recommended treatment in surgically unresectable or incomplete resection or in the presence of severe comorbidities.

Objective: To evaluate the clinical features and outcomes of patients with ACC of trachea-bronchi treated with radiotherapy. Read More

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The Chimeric Scapulodorsal Vascularized Latissimus Dorsi Nerve Flap for Immediate Reconstruction of Total Parotidectomy Defects With Facial Nerve Sacrifice: Building a New Program and Preliminary Results From 25 Cases.

Ann Plast Surg 2021 05;86(5S Suppl 3):S379-S383

Plastic Surgery Department, Gustave Roussy Cancer Campus, Villejuif, France.

Background: Total parotidectomy with facial nerve sacrifice creates 2 challenging reconstructive problems: restoration of facial contour and facial nerve rehabilitation. Strong evidence suggesting that vascularized nerve grafts are superior to nonvascularized nerve grafts motivated our team to develop a chimeric scapulodorsal flap combining the usual harvestable local tissues with the vascularized latissimus dorsi motor nerve (SD-LDVxN). We present our experiences developing a new program at University of California, San Diego, highlighting our first case here, and present preliminary retrospective results focusing on the functional outcomes of facial nerve reanimation. Read More

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Intramedullary spinal cord metastasis from an adenoid cystic carcinoma of the external auditory canal: case report.

Br J Neurosurg 2021 May 10:1-5. Epub 2021 May 10.

Department of Neurosciences, Biomedicine and Movement Sciences, Section of Neurosurgery, Borgo Trento University Hospital, University of Verona, Verona, Italy.

Background And Importance: Intramedullary spinal cord metastases (ISCMs) are rare and no cases of ISCM from an adenoid cystic carcinoma (ACC) of the external auditory canal (EAC) have been reported.

Clinical Presentation: We report a 54-year old man complaining backpain and worsening myelopathy. He had an ACC of the EAC resected years prior. Read More

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Utilization of Nivolumab in Adenoid Cystic Carcinoma After Progression on Platinum-Based Chemotherapy.

Perm J 2021 May;25

Ochsner Cancer Institute, New Orleans, LA.

Introduction: Adenoid cystic carcinoma (ACC) is a rare malignant neoplasm within the secretory glands of the head and neck. Clinical findings include a lump on the palate, tongue, or bottom of the mouth. Because symptoms can be mild, patients go for long periods of time without investigation. Read More

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Impact of anatomic site of distant metastasis on survival in salivary gland cancers.

Head Neck 2021 May 7. Epub 2021 May 7.

Department of Radiation Oncology, University of Illinois Hospital and Health Sciences System, Chicago, Illinois, USA.

Background: As exemplified in patients with adenoid cystic carcinoma (ACC), metastatic salivary gland cancers display heterogenous behavior. Although anatomic site of metastasis has been suggested to be prognostic for survival in this population, this is not adequately characterized in the current literature.

Methods: Using the National Cancer Database (NCDB), patients with newly diagnosed metastatic salivary gland cancers with distant metastasis to a single organ were identified. Read More

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Preclinical development and first in human study of KA2507, a selective and potent inhibitor of histone deacetylase 6, for patients with refractory solid tumors.

Clin Cancer Res 2021 May 4. Epub 2021 May 4.

Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center.

Purpose: Inhibition of histone deacetylase 6 (HDAC6) is predicted to deliver both direct antitumor activity and modulation of the antitumor immune response. This study describes the development of a novel HDAC6 inhibitor.

Patients And Methods: KA2507 was characterized in HDAC biochemical and cellular target engagement assays and in preclinical efficacy models of melanoma and colorectal cancer. Read More

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Ga-FAPI-PET/CT improves diagnostic staging and radiotherapy planning of Adenoid Cystic Carcinomas - imaging analysis and histological validation.

Radiother Oncol 2021 Apr 30. Epub 2021 Apr 30.

Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany; Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg, Germany.

Background: Adenoid cystic carcinomas (ACCs) are rare epithelial tumors mostly situated in the head and neck region and characterized by infiltrative growth. The tumor stroma of ACCs includes cancer-associated fibroblasts (CAFs) expressing Fibroblast Activation Protein (FAP), a new target for positron emission tomography (PET) imaging. Here we describe the value of PET/ computed tomography (PET/CT) imaging using Ga-labelled FAP-Inhibitors (Ga-FAPI-PET/CT) and their clinical potential for staging and radiotherapy planning in 12 ACC patients (7 primary, 5 recurrent). Read More

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Identification and characterization of primary cilia-positive salivary gland tumours exhibiting basaloid/myoepithelial differentiation.

J Pathol 2021 Apr 30. Epub 2021 Apr 30.

Department of Tumor Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan.

Primary cilia (PC) are non-motile, antenna-like structures on the cell surface. Many types of neoplasms exhibit PC loss, whereas in some neoplasms PC are retained and involved in tumourigenesis. To elucidate the PC status and characteristics of major salivary gland tumours (SGTs), we examined 100 major SGTs encompassing eight histopathological types by immunohistochemical analysis. Read More

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Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland-A 26-Year, Clinicopathologic, Retrospective Analysis.

J Clin Med 2021 Apr 13;10(8). Epub 2021 Apr 13.

Department of Cranio-Maxillofacial Surgery, Jagiellonian University Medical College, 31-008 Cracow, Poland.

(1) Background: Epidemiological studies of epithelial salivary gland neoplasms are difficult to conduct effectively due to tumor rarity, histological heterogeneity, tumor location diversity, and a lack of national registries collecting data. This study presents 26 years of epidemiological data from a single institution in southern Poland that estimates incidence rates of primary epithelial salivary gland tumors. (2) Methods: The charts of 805 patients with epithelial salivary gland tumors were retrospectively reviewed. Read More

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[Adenoid cystic carcinoma of the male breast: report of a case].

Zhonghua Bing Li Xue Za Zhi 2021 May;50(5):535-537

Department of Pathology, Renmin Hospital of Wuhan University, Wuhan 430060, China.

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Management of Salivary Gland Malignancy: ASCO Guideline.

J Clin Oncol 2021 Apr 26:JCO2100449. Epub 2021 Apr 26.

University of California San Francisco, San Francisco, CA.

Purpose: To provide evidence-based recommendations for practicing physicians and other healthcare providers on the management of salivary gland malignancy.

Methods: ASCO convened an Expert Panel of medical oncology, surgical oncology, radiation oncology, neuroradiology, pathology, and patient advocacy experts to conduct a literature search, which included systematic reviews, meta-analyses, randomized controlled trials, and prospective and retrospective comparative observational studies published from 2000 through 2020. Outcomes of interest included survival, diagnostic accuracy, disease recurrence, and quality of life. Read More

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Pan-TRK Immunohistochemistry Is Highly Correlated With NTRK3 Gene Rearrangements in Salivary Gland Tumors.

Am J Surg Pathol 2021 Apr 23. Epub 2021 Apr 23.

Department of Pathology, Centre Henri Becquerel INSERM 1245, Rouen Normandy Uniiversity Department of Pathology, Rouen University Hospital, Rouen Platform of Experimental Pathology, Department of Diagnostic and Theranostic Medicine, Curie Institute Department of Pathology, Lariboisière Hospital, Paris, France.

Aims: Secretory carcinoma (SC) is characterized by ETV6 rearrangements, most often ETV6-NTRK3 fusion. Given its histologic overlap with other salivary gland tumors (SGTs), SCs can be difficult to diagnose without genetic confirmation. A recently developed pan-TRK (tropomyosin receptor kinase) antibody shows promise for identifying tumors with NTRK (neurotrophic tyrosine kinase receptor 3) fusions. Read More

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Exploration of High-Grade Transformation and Postoperative Radiotherapy on Prognostic Analysis for Primary Adenoid Cystic Carcinoma of the Head and Neck.

Front Oncol 2021 9;11:647172. Epub 2021 Apr 9.

Department of Pathology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Background: Despite Adenoid cystic carcinoma (ACC) with cribriform or tubular components being recognized as a potentially indolent malignancy, ACC displaying solid or, more rarely, high-grade transformation (HGT) components is considered a more aggressive variant of the disease. As it is difficult to measure the proportion of the solid component objectively, and the role of HGT in the current grading system remains unclear, the prognostic influence of tumor grading remains controversial. In addition, postoperative radiotherapy (PORT) has been proven to be effective in local control of ACC of the head and neck (ACCHN) with a high rate of nerve invasion and close surgical margin. Read More

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Diagnostic discrepancy in second opinion reviews of primary epithelial neoplasms involving salivary gland: An 11-year experience from a tertiary referral center focusing on useful pathologic approaches and potential clinical impacts.

Head Neck 2021 Apr 24. Epub 2021 Apr 24.

Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.

Aims: In the era of precision medicine, accurate pathologic diagnoses are crucial for appropriate management.

Methods: We herein described the histologic features and clinical impacts of 66 salivary gland epithelial neoplasms in which the diagnosis was altered after expert review.

Results: The most common revised diagnosis was that of salivary duct carcinoma (SDC, n = 12), adenoid cystic carcinoma (n = 12), and myoepithelial carcinoma (n = 10). Read More

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SalvGlandDx - a comprehensive salivary gland neoplasm specific next generation sequencing panel to facilitate diagnosis and identify therapeutic targets.

Neoplasia 2021 May 18;23(5):473-487. Epub 2021 Apr 18.

Department of Pathology and Molecular Pathology, University Hospital Zurich, Zurich, Switzerland; University of Zurich, Zurich, Switzerland. Electronic address:

Diagnosis of salivary gland neoplasms is often challenging due to their high morphological diversity and overlaps. Several recurrent molecular alterations have been described recently, which can serve as powerful diagnostic tools and potential therapeutic targets (e.g. Read More

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Similar therapeutic effects of I seed radiotherapy and γ-ray radiotherapy on lacrimal gland adenoid cystic carcinoma.

Int J Ophthalmol 2021 18;14(4):547-553. Epub 2021 Apr 18.

Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing 100730, China.

Aim: To evaluate the survival outcomes of patients with lacrimal gland adenoid cystic carcinoma who underwent eye-sparing surgery combined with I seed implantation radiotherapy or local external γ-ray radiotherapy.

Methods: In this retrospective comparative case series, the clinical records of 27 primary and 8 recurrent patients were reviewed. Univariate and multivariate analyses were used to identify risk factors associated with distant metastasis (DM), and the overall survival (OS) after the initial surgery was analyzed. Read More

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Patterns of Care and Outcomes of Primary Adenoid Cystic Carcinoma of the Trachea.

Ann Otol Rhinol Laryngol 2021 Apr 19:34894211008101. Epub 2021 Apr 19.

Department of Otolaryngology-Head and Neck Surgery, Rutgers New Jersey Medical School, Newark, NJ, USA.

Objective: Primary tracheal malignancies are relatively rare cancers, representing 0.1% to 0.4% of all malignancies. Read More

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Clinical Utility of Fine Needle Aspiration Cytology for Adenoid Cystic Carcinoma of the Trachea with Thyroid Invasion: A Case Report.

J Nippon Med Sch 2021 Apr 19. Epub 2021 Apr 19.

Department of Endocrine Surgery, Nippon Medical School.

Background: Adenoid cystic carcinoma of the trachea (ACCT) is a rare cancer; ACCT with thyroid invasion is particularly rare. We first suspected anaplastic thyroid carcinoma (ATC) but diagnosed ACC after performing fine needle aspiration cytology (FNAC). A tracheal origin was confirmed after operation. Read More

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Solitary Renal Metastasis Arising from a Pulmonary Adenoid Cystic Carcinoma: A Case Report and Review of the Literature.

Case Rep Urol 2021 30;2021:8863475. Epub 2021 Mar 30.

Histopathology and Cytology Laboratory Services, Nicosia, Cyprus.

Adenoid cystic carcinoma (ACC) is a malignancy affecting the salivary glands and rarely involving the lung. Due to its rarity, primary lung ACC remains incompletely understood. We herein report the case of a 57-year-old female patient who was initially diagnosed with primary lung ACC and was treated by lobectomy. Read More

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Clinical and Demographic Factors, Treatment Patterns, and Overall Survival Associated With Rare Triple-Negative Breast Carcinomas in the US.

JAMA Netw Open 2021 Apr 1;4(4):e214123. Epub 2021 Apr 1.

Department of Hematology-Oncology, Maroone Cancer Center, Cleveland Clinic Florida, Weston, Florida.

Importance: Triple-negative breast cancers are known collectively to demonstrate a more aggressive clinical course and earlier recurrence than cancers of other histological subtypes. However, the literature on rare triple-negative breast cancers and the association of histological type with survival and risk of metastasis is sparse.

Objective: To present the clinical and demographic characteristics, treatment patterns, and overall survival (OS) for histologically rare (<10% of breast cancers) triple-negative breast cancer types: medullary carcinoma, adenoid cystic carcinoma, and metaplastic breast carcinoma. Read More

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Immunohistochemical Expression of Fatty Acid Synthase (FASN) is Correlated to Tumor Aggressiveness and Cellular Differentiation in Salivary Gland Carcinomas.

Head Neck Pathol 2021 Apr 11. Epub 2021 Apr 11.

Department of Pathology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 126, Tessalia Vieira de Camargo Street, Cidade Universitaria, Campinas, São Paulo, 13083887, Brazil.

Fatty acid synthase (FASN) expression is closely related to cancer progression, in particular, tumor aggressiveness and poor prognosis. This study aimed to analyse the expression of FASN in carcinomas of the salivary glands and correlate it with Ki-67 expression. We analysed by immunohistochemistry the expression of FASN and Ki-67 on tissue sections from 7 cases of adenocarcinoma, not otherwise specified (AdNOS), 6 cases of polymorphous adenocarcinoma (PAC), 16 cases of acinic cell carcinoma (AcCC), 19 cases of adenoid cystic carcinoma (AdCC), 15 cases of epithelial-myoepithelial carcinoma (EMC); 10 cases of secretory carcinoma (SC), 13 cases of mucoepidermoid carcinoma (MEC), 10 cases of salivary duct carcinoma (SDC) and 7 cases of myoepithelial carcinoma (MC). Read More

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Potential targets identified in adenoid cystic carcinoma point out new directions for further research.

Am J Transl Res 2021 15;13(3):1085-1108. Epub 2021 Mar 15.

Department of Oral and Maxillofacial Surgery, Jinan Stomatological Hospital Jinan, China.

Adenoid cystic carcinoma (AdCC) of the head and neck originates from salivary glands, with high risks of recurrence and metastasis that account for the poor prognosis of patients. The purpose of this research was to identify key genes related to AdCC for further investigation of their diagnostic and prognostic significance. In our study, the AdCC sample datasets GSE36820, GSE59702 and GSE88804 from the Gene Expression Omnibus (GEO) database were used to explore the abnormal coexpression of genes in AdCC compared with their expression in normal tissue. Read More

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Stereotactic body radiotherapy for adenoid cystic carcinoma metastatic to the lung: a case report.

J Med Case Rep 2021 Apr 11;15(1):156. Epub 2021 Apr 11.

Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma, 371-8511, Japan.

Background: Adenoid cystic carcinoma (ACC) is a rare malignant tumor involving mostly the head and neck region, and frequently the salivary glands. The development of lung metastasis after treatment of the primary tumor is a common occurrence in ACC. Although lung metastases show a slow rate of growth, approximately 10% of patients die from distant metastases. Read More

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[Free anterolateral thigh flap with superficial temporal vessels as recipient vessels for reconstruction of defect after maxillectomy in malignant tumor].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2021 Apr;56(4):369-373

Department of Oral and Maxillofacial Surgery, the Second Xiangya Hospital of Central South University, , Changsha 410011, China.

To study the effects of superficial temporal artery and vein as recipient vessels for the free anterolateral thigh flap on the appearance and functions after maxillectomy. Clinical data of 21 patients with malignant maxillary tumors in Department of Oral and Maxillofacial Surgery, the Second Xiangya Hospital of Central South University from January 2014 to November 2019, who were treated by free anterolateral thigh flap with temporal superficial vessels as the recipient vessels were analyzed retrospectively. There were 18 males and 3 females, with the age ranging from 29 to 73 years old, including 19 cases of squamous carcinoma, 1 case of adenoid cystic carcinoma and 1 case of osteosarcoma. Read More

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[Recurrence of ceruminous gland adenoid cystic carcinoma with intracranial dissemination: report of a case].

Zhonghua Bing Li Xue Za Zhi 2021 Apr;50(4):405-408

Department of Pathology, the First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China.

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Adenomyoepithelioma of the breast: A proposal for classification.

Histopathology 2021 Apr 7. Epub 2021 Apr 7.

Department of Histopathology, St Vincent's University Hospital, University College, Dublin, Ireland.

Breast lesions with a prominent myoepithelial cell component constitute a heterogeneous group of benign and malignant neoplastic proliferations. These lesions are often dual epithelial-myoepithelial but may be purely myoepithelial cell in nature. Benign epithelial-myoepithelial lesions typically maintain the morphology and immunophenotype of the normal bilayer epithelial myoepithelial structures. Read More

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