7,949 results match your criteria Cylindroma


Pleomorphic Adenoma of External Auditory Canal: Case Report of First Endoscopic Resection and Literature Review.

Medicina (Kaunas) 2020 May 20;56(5). Epub 2020 May 20.

Department of Otorhinolaryngology, Head and Neck Surgery, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Ceruminous pleomorphic adenoma is a very rare, mostly benign tumor originating from the ceruminal glands in the external auditory canal. Histologically, it is a mixed tumor with epithelial and stromal parts of different proportions, and is recognized today by the World Health Organization (WHO) as a ceruminous adenoma. Similar to the pleomorphic adenoma of salivary glands, recurrence or malignant degeneration with cellular atypia and metastasis can occur on rare occasions. Read More

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http://dx.doi.org/10.3390/medicina56050248DOI Listing

Evaluation of VEGF expression correlates with COX-2 expression in pleomorphic adenoma, mucoepidermoid carcinoma and adenoid cystic carcinoma.

Dent Res J (Isfahan) 2020 Mar-Apr;17(2):100-106. Epub 2020 Mar 17.

Department of Endodontics, School of Dentistry, Tabriz University of Medical Sciences, Tabriz, Iran.

Background: Pleomorphic adenoma (PA), mucoepidermoid carcinoma (MEC), and adenoid cystic carcinoma (AdCC) are the most common benign and malignant salivary gland tumors. Cyclooxygenase-2 (COX-2) is a key regulatory enzyme that its overexpression in various tumors is correlated with progression, metastasis, and apoptosis inhibition. Vascular endothelial growth factor (VEGF) is a potent angiogenic mediator that has an important role in neoplastic angiogenesis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7224257PMC

Treatment outcomes of patients with tracheobronchial mucoepidermoid carcinoma compared with those with adenoid cystic carcinoma.

Eur J Surg Oncol 2020 May 5. Epub 2020 May 5.

Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:

Objective: Tracheobronchial mucoepidermoid carcinoma (TMEC) is an extremely rare salivary gland-type neoplasm. We aimed to explore the clinical characteristics and prognosis of TMEC and to compare them with those of another rare salivary gland-type neoplasm, tracheobronchial adenoid cystic carcinoma (TACC).

Method: We performed a retrospective review of all patients pathologically diagnosed with TMEC between 1965 and 2017 at our institution. Read More

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http://dx.doi.org/10.1016/j.ejso.2020.04.020DOI Listing

Clinical outcomes of head and neck adenoid cystic carcinoma patients treated with pencil beam-scanning proton therapy.

Oral Oncol 2020 May 12;107:104752. Epub 2020 May 12.

Center for Proton Therapy, Paul Scherrer Institute, Villigen PSI, Switzerland; Radiation Oncology Department, University Hospital Zürich, Zürich, Switzerland; Radiation Oncology Department, University Hospital Bern, Inselspital, Bern, Switzerland. Electronic address:

Objective: The aim of this study was to evaluate the outcome of patients with head and neck adenoid cystic carcinoma (ACC) treated using pencil beam scanning proton therapy (PBS PT) at our institution.

Materials And Methods: Thirty-five patients who underwent treatment with PBS PT for ACC between 2001 and 2017 were included. Local control (LC), distant control (DC), progression-free survival (PFS), overall survival (OS) and their prognostic factors were evaluated. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104752DOI Listing
May 2020
3.607 Impact Factor

Adenoid Cystic Carcinoma of Bartholin's Gland: What Is the Best Approach?

Oncology 2020 May 14:1-7. Epub 2020 May 14.

National Center of Oncological Hadrontherapy (Fondazione CNAO), Pavia, Italy.

Background and summary: Among all vulvar cancers, primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a very rare tumor characterized by a slow growth, a high local aggressiveness, and a remarkable recurrence rate. Due to its rarity, treatment remains a challenge for oncologists and gynecological surgeons. Key message: The present paper reports clinical, radiological, and histological features of ACC of Bartholin's gland and reviews the literature data on the treatment options with a particular focus on the potential role of particle radiation therapy. Read More

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http://dx.doi.org/10.1159/000506485DOI Listing

Primary Adenoid Cystic Carcinoma of the Upper Anterior Mediastinum Mimicking a Thyroid Tumor: A Case Report and Review of Literature.

Front Endocrinol (Lausanne) 2020 23;11:242. Epub 2020 Apr 23.

Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan, China.

Primary adenoid cystic carcinoma (ACC) of the upper anterior mediastinum mimicking a thyroid tumor has rarely been seen in clinical practice and lacks a standard of care therapy. Here, we report a 47-year old female patient with an ACC originated from the upper anterior mediastinum presenting as a thyroid gland tumor. The patient received gross surgical resection of the tumor and underwent post-surgical chemotherapy and radiotherapy. Read More

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http://dx.doi.org/10.3389/fendo.2020.00242DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7191109PMC

Clinical characteristics and treatment outcome of adenoid cystic carcinoma in the external auditory canal.

Biomed J 2020 May 7. Epub 2020 May 7.

Department of Otolaryngology & Head and Neck Surgery, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; College of Medicine, Chang Gung University, Taoyuan, Taiwan. Electronic address:

Background: This study reviewed the clinical manifestations, pathological findings, and treatment outcomes of adenoid cystic carcinoma (ACC) in the external auditory canal (EAC).

Methods: This was a retrospective review of 12 patients with a diagnosis of ACC in the EAC seen in a single institution over a 30-year period. Data on the demographics, clinical presentation, treatment strategy, and outcome, as well as the pathological features of ACC, were reviewed and analyzed. Read More

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http://dx.doi.org/10.1016/j.bj.2019.07.005DOI Listing

A potential protective effect of metformin in adenoid cystic carcinoma.

Oral Oncol 2020 May 7;107:104726. Epub 2020 May 7.

Department of Otolaryngology-Head & Neck Surgery, The Ohio State Wexner Medical Center, 915 Olentangy River Road, Columbus, OH 43212, USA. Electronic address:

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http://dx.doi.org/10.1016/j.oraloncology.2020.104726DOI Listing

Role of hypoxia-related proteins in adenoid cystic carcinoma invasion.

Diagn Pathol 2020 May 9;15(1):47. Epub 2020 May 9.

Department of Oral Pathology, School of Dentistry, Universidade Federal do Pará, Avenida Augusto Correa, 01, Belem, Para, 66075-110, Brazil.

Background: Among cancers affecting the oral cavity, adenoid cystic carcinoma (ACC) is a relatively common malignant neoplasm. It has high rates of metastasis and recurrence and is associated with significant morbidity. During the progression of ACC, the oxygen concentration is reduced in specific areas of the tumour microenvironment, leading to intratumoural hypoxia. Read More

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http://dx.doi.org/10.1186/s13000-020-00967-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7210690PMC

Extensive and aggressive growth of adenoid cystic carcinoma in the lacrimal gland.

Arch Craniofac Surg 2020 Apr 20;21(2):114-118. Epub 2020 Apr 20.

Department of Plastic and Reconstructive Surgery, Chung-Ang University Hospital, Chung-Ang University College of Medicine, Seoul, Korea.

Adenoid cystic carcinoma (ACC) in the lacrimal gland is a very rare disease with poor overall prognosis. Its primary treatment is surgical excision, including orbital exenteration and radical orbitectomy, which is combined with radiotherapy and chemotherapy. Age, histopathologic type, bone invasion, and tumor extent are known factors that affect the prognosis of ACC. Read More

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http://dx.doi.org/10.7181/acfs.2019.00479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7206458PMC

Locally advanced orofacial malignancy: Synopsis of inoperable lesions at an urban tertiary health facility in Nigeria.

Niger J Clin Pract 2020 May;23(5):691-696

Department of Oral and Maxillofacial Surgery, University of Benin Teaching Hospital; University of Benin, Benin-City, Nigeria.

Background: Locally advanced inoperable orofacial malignancies do present clinically, and constitute a significant public health burden worldwide.

Objective: To determine the prevalence and clinical characteristics of Stage IV locally advanced inoperable orofacial malignancies for consecutive patients.

Materials And Methods: A 24-year retrospective study was undertaken, and data obtained from hospital register, case files, and histopathological reports of patients were recorded in a proforma. Read More

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http://dx.doi.org/10.4103/njcp.njcp_607_19DOI Listing

Genotype-phenotype associations in breast pathology: Achievements of the past quarter century.

Breast J 2020 May 4. Epub 2020 May 4.

Geisel School of Medicine at Dartmouth, Lebanon, NH, USA.

The first genotype-phenotype relationship in breast pathology developed in 1994 with the discovery of the CDH1 gene. This finding eventually provided biological insight into the characteristic morphology of invasive lobular carcinoma. Subsequent investigative efforts have uncovered additional molecular alterations largely responsible for the histology of several breast neoplasms including secretory carcinoma, adenoid cystic carcinoma, tall cell carcinoma with reversed polarity, fibroepithelial lesions, and most recently, adenomyoepithelioma. Read More

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http://dx.doi.org/10.1111/tbj.13861DOI Listing

Efficacy of cyclophosphamide, doxorubicin, and cisplatin for adenoid cystic carcinoma, and their relationship with the pre-chemotherapy tumor growth rate.

Chin Clin Oncol 2020 Apr;9(2):15

Department of Internal Medicine, Seoul Na'tional University Hospital, Seoul, Korea; Cancer Research Institute, Seoul National University College of Medicine, Seoul, Korea.

Background: While surgical resection is the treatment of choice for adenoid cystic carcinoma (ACC), patients with metastasis and those who cannot undergo surgery receive palliative chemotherapy. However, the role of palliative chemotherapy is not clear yet. This study aimed to evaluate the efficacy of chemotherapy with cyclophosphamide, doxorubicin, and cisplatin (CAP) for patients with ACC; and to analyze the relationship between the pre-chemotherapy tumor growth rate (P-TGR) and treatment outcomes in patients with the recurred metastatic unresectable ACC. Read More

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http://dx.doi.org/10.21037/cco.2020.03.07DOI Listing

Expression of TdT in Myoepithelial Cells: Investigation in Breasts, Sweat Glands, and Salivary Lesions Emphasizing the Never-Documented Immunohistochemical Findings.

Int J Surg Pathol 2020 May 4:1066896920916792. Epub 2020 May 4.

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.

. The expression of terminal deoxynucleotidyl transferase (TdT) in myoepithelial cells (MECs) within the breast was recently incidentally observed in our routine practice. This study aimed to elucidate the expression of TdT in MECs. Read More

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http://dx.doi.org/10.1177/1066896920916792DOI Listing

Adenoid cystic carcinoma of the Bartholin gland is not HPV-related: A case report and review of literature.

Pathol Res Pract 2020 Apr 19:152968. Epub 2020 Apr 19.

Department of Pathology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands; Department of Pathology, University Clinics Saint-Luc, Brussels, Belgium. Electronic address:

Adenoid cystic carcinoma (ACC) of the Bartholin gland is a rare gynaecological entity. Despite its slow growth and inconspicuous presentation, vulvar ACC has a propensity for perineural invasion and is therefore associated with high local recurrence rates. We report a case of vulvar ACC in a 61-year-old woman with a prolonged swelling of the Bartholin gland. Read More

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http://dx.doi.org/10.1016/j.prp.2020.152968DOI Listing

National Utilization of Surgery and Outcomes for Primary Tracheal Cancer in the United States.

Ann Thorac Surg 2020 Apr 23. Epub 2020 Apr 23.

Thoracic Surgery Division, Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH. Electronic address:

Background: Tracheal cancer (TC) is a rare disease and surgical treatment requires a high level of expertise. We sought to determine the treatment patterns and surgical outcomes of TC in the United States.

Methods: The National Cancer Database was queried for all cases of primary invasive TC without distant metastatic disease between 2004-2015. Read More

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http://dx.doi.org/10.1016/j.athoracsur.2020.03.048DOI Listing

Bargain with the tooth fairy - The savings accounts for dental stem cells.

Biomed J 2020 Apr 22. Epub 2020 Apr 22.

University of Copenhagen, BRIC Biotech Research & Innovation Centre, Anders Lund Group, Copenhagen, Denmark. Electronic address:

Despite the hard times COVID-19 has imposed on us, the Biomedical Journal strives to provide fresh and compelling reading material - to be enjoyed safely from home. In this issue, we glance behind the scenes of dental stem cell preservation for potential therapeutic use, and discover that cancer cells hijack podoplanin expression to induce thrombosis. Moreover, we learn how the helicase DDX17 promotes tumour stemness, how genetic defects in meiosis and DNA repair cause premature ovarian insufficiency, and that the brain-derived neurotrophic factor is associated with several psychiatric diseases. Read More

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http://dx.doi.org/10.1016/j.bj.2020.04.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7195095PMC

Targeted deep sequencing helps distinguish independent primary tumors from intrapulmonary metastasis for lung cancer diagnosis.

J Cancer Res Clin Oncol 2020 Apr 24. Epub 2020 Apr 24.

Department of Thoracic Surgery, Peking University Shenzhen Hospital, 1120 Lianhua Road, Shenzhen, 518035, People's Republic of China.

Purpose: Multiple lung lesions found in a single patient at the time of diagnosis often pose a diagnostic dilemma: are these lesions independent primary tumors (IPT) or the result of intrapulmonary metastases (IPM)? While traditional pathological methods sometimes have difficulty distinguishing IPM from IPT, modern molecular profiling based on next-generation sequencing techniques may provide a new strategy.

Methods: Sixteen patients with multiple tumors were enrolled in this study. We performed targeted deep sequencing (~ 2000 × coverage) on a total of 40 tumors and matched blood samples. Read More

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http://dx.doi.org/10.1007/s00432-020-03227-5DOI Listing

Epithelial-Myoepithelial Carcinoma of the Lacrimal Gland: Case Report of Youngest Patient.

Ophthalmic Plast Reconstr Surg 2020 Apr 17. Epub 2020 Apr 17.

Ophthalmology, Dr. Rajendra Prasad Centre for Ophthalmic Sciences.

The authors report a case of extremely uncommon malignancy of lacrimal gland epithelial-myoepithelial carcinoma. This carcinoma is more commonly encountered in salivary glands and comprises 1% of all salivary gland tumors. Its occurrence in the orbit is very rare with only 6 cases reported in the literature, most of which arose in a pleomorphic adenoma. Read More

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http://dx.doi.org/10.1097/IOP.0000000000001663DOI Listing

Incidence and survival trends of parotid malignancies over 42 years.

Head Neck 2020 Apr 21. Epub 2020 Apr 21.

Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA.

Background: There is a paucity of information regarding the incidence and survival of parotid malignancies over time.

Methods: The Surveillance, Epidemiology, and End Results population-based cancer registry was queried for parotid malignancies from 1973 to 2015.

Results: The age-adjusted incidence of parotid malignancies has increased by 58. Read More

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http://dx.doi.org/10.1002/hed.26172DOI Listing

Neck Dissection for Adenoid Cystic Carcinoma.

Ann Surg Oncol 2020 Apr 20. Epub 2020 Apr 20.

Department of Radiation Oncology, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1245/s10434-020-08501-xDOI Listing

Squamous Cell and Adenoid Cystic Carcinoma Collision Tumor of the Soft Palate Treated with Surface Mold Brachytherapy.

Cureus 2020 Mar 17;12(3):e7297. Epub 2020 Mar 17.

Radiation Oncology, University of Louisville, Louisville, USA.

Simultaneous primary cancers are rare in the oropharynx. This report describes the first reported case of a collision tumor of squamous cell and adenoid cystic carcinoma in the soft palate. The patient was immunosuppressed with a history of liver transplantation, smoking and heavy alcohol drinking. Read More

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http://dx.doi.org/10.7759/cureus.7297DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7163338PMC

The Benefits of Adjuvant Trastuzumab for HER-2-Positive Salivary Gland Cancers.

Oncologist 2020 Apr 20. Epub 2020 Apr 20.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

Background: Although high-grade salivary gland cancers (SGCs) often express androgen receptor (AR) and/or HER-2/neu, therapeutically targeting these receptors in SGC remains investigational. We investigated the prevalence of receptor expression and the benefit of adjuvant HER-2 directed therapy in the high-risk postoperative setting and explored the clinical utility of sequentially targeting these receptors in the setting of advanced disease.

Materials And Methods: We clinically annotated 95 patients with SGC (excluding adenoid cystic carcinoma) treated at our institution from 2002 to 2019 and recorded AR, HER-2/neu status, and tumor genomic profiling results when available. Read More

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http://dx.doi.org/10.1634/theoncologist.2019-0841DOI Listing

[Diagnosis, prognosis and treatment of sinonasal carcinomas (excluding melanomas, sarcomas and lymphomas)].

Bull Cancer 2020 Apr 15. Epub 2020 Apr 15.

French Rare Head and Neck Cancer Expert Network, France.

Sinonasal carcinomas account for 3% of ENT cancers. They are subdivided into squamous cell carcinomas (50%), adenocarcinomas [20%, mostly of intestinal type (ITAC)], and more rarely, adenoid cystic carcinomas, olfactory neuroblastomas (=esthesioneuroblastomas), neuroendocrine carcinomas or undifferentiated sinonasal carcinomas (SNUC). The 5-year survival rates are, in descending order, 72% for neuroblastomas, 63% for adenocarcinomas, 50-60% for large-cell neuroendocrine carcinomas, 53% for squamous cell carcinomas, 25-50% for adenoid cystic, 35% for small-cell neuroendocrine carcinomas and 35% for SNUC and newly discovered histologies. Read More

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http://dx.doi.org/10.1016/j.bulcan.2020.02.013DOI Listing
April 2020
0.635 Impact Factor

Long-term outcomes and clinicogenomic correlates in recurrent, metastatic adenoid cystic carcinoma.

Oral Oncol 2020 Apr 10;106:104690. Epub 2020 Apr 10.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; BC Cancer, Vancouver Centre, 600 West 10th Avenue, Vancouver, BC V5Z 4E6, Canada.

Background: Little is known about the long-term impact of local and systemic therapies for recurrent/metastatic (R/M) adenoid cystic carcinoma (ACC), or the clinical significance of molecular alterations.

Methods: We identified 72 R/M cases among 123 ACC patients from our institution. We report long-term outcomes, predictors of recurrence and survival, and the impact of sequential cancer-directed therapy among R/M patients. Read More

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http://dx.doi.org/10.1016/j.oraloncology.2020.104690DOI Listing

Metastatic adenoid cystic carcinoma with high-grade transformation ("dedifferentiation") in pleural effusion and neck lymph node: A diagnostic challenge on cytology?

Diagn Cytopathol 2020 Apr 9. Epub 2020 Apr 9.

Department of Pathology, McGill University, Montreal, Quebec, Canada.

High-grade transformation (HGT) or "dedifferentiation" is an uncommon phenomenon among salivary gland carcinomas including adenoid cystic carcinoma (ACC), which is important to recognize because it is associated with increased tumor aggressiveness, with a high propensity for lymph node and distant metastases. ACC with HGT is histologically characterized by a distinct population of poorly differentiated cells with loss of the typical biphasic ductal and myoepithelial differentiation seen in conventional ACC, associated with pleomorphism, necrosis and increased mitotic activity. We report the cytologic features of a case of metastatic ACC-HGT in cervical lymph node and effusion, which, to the best of our knowledge, have not been described previously. Read More

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http://dx.doi.org/10.1002/dc.24431DOI Listing

Liver metastasis from adenoid cystic carcinoma of the submandibular gland: a case report.

Int J Clin Exp Pathol 2020 1;13(3):550-555. Epub 2020 Mar 1.

Department of Radiology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University Changsha, Hunan, China.

Background: Adenoid cystic carcinoma (ACC) is a rare malignancy of epithelial origin. It involves a variety of histologic types and often has distant metastasis. ACC metastasis to the liver is rare and usually involves spread to other organs. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7137005PMC

Prognostic Impact of PD-L1 Expression in Malignant Salivary Gland Tumors as Assessed by Established Scoring Criteria: Tumor Proportion Score (TPS), Combined Positivity Score (CPS), and Immune Cell (IC) Infiltrate.

Cancers (Basel) 2020 Apr 3;12(4). Epub 2020 Apr 3.

Institute of Pathology and Molecular Pathology, Bundeswehrkrankenhaus Ulm, Oberer Eselsberg 40, 89081 Ulm, Germany.

Background: Malignant neoplasms of the salivary glands are rare, and therapeutic options are limited. Results from recently published studies indicate a possible use for checkpoint inhibition in a subset of patients, but there are no established criteria for programme cell death ligand 1 (PD-L1) scoring in salivary gland carcinomas (SGCs).

Methods: In this retrospective study, we present a cohort of 94 SGC patients with full clinical follow-up. Read More

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http://dx.doi.org/10.3390/cancers12040873DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226358PMC

Lymphocyte activation gene 3 (LAG3) protein expression on tumor-infiltrating lymphocytes in aggressive and TP53-mutated salivary gland carcinomas.

Cancer Immunol Immunother 2020 Mar 30. Epub 2020 Mar 30.

Department of Otorhinolaryngology, Head and Neck Surgery, Medical Faculty, University of Cologne, Cologne, Germany.

Salivary gland carcinomas (SGCs) are rare and can be subdivided into distinct entities, some of which confer a poor prognosis. As targets for effective systemic therapy are warranted, some studies investigated the role of immune-checkpoint proteins PD-L1 and CTLA-4 in SGC. Our study depicts the expression of lymphocyte activation gene 3 (LAG3) in a test cohort and a larger validation cohort, totaling 139 SGCs. Read More

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http://dx.doi.org/10.1007/s00262-020-02551-6DOI Listing

Roles of Proteoglycans in the Tumourigenesis and Development of Adenoid Cystic Carcinoma and Pleomorphic Adenoma of the Salivary Gland: A Systematic Review.

Chin J Dent Res 2020 ;23(1):11-25

Salivary adenoid cystic carcinoma (ACC) and pleomorphic adenoma (PA) are the most common types of salivary gland tumours; the former is malignant and the latter is benign but with features of a border tumour. Proteoglycans (PGs) produced by neoplastic myoepithelial cells are ubiquitous in both types of tumours. However, normal myoepithelial cells of salivary glands do not have the ability to secrete PGs. Read More

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http://dx.doi.org/10.3290/j.cjdr.a44332DOI Listing

Role of concurrent chemoradiation on locally advanced unresectable adenoid cystic carcinoma.

Korean J Intern Med 2020 Mar 30. Epub 2020 Mar 30.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Background/aims: Adenoid cystic carcinoma (ACC) is a rare salivary gland tumor characterized by indolence, with a high rate of local recurrence and distant metastasis. This study aimed to investigate the effect of concurrent chemoradiation (CCRT) on locally advanced unresectable ACC.

Methods: We retrospectively analyzed clinical data from 10 patients with pathologically confirmed ACC of the head and neck who received CCRT with cisplatin in Seoul National University Hospital between 2013 and 2018. Read More

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http://dx.doi.org/10.3904/kjim.2019.104DOI Listing

Submandibular gland cancers: prognostic factors and survival analysis.

Eur Arch Otorhinolaryngol 2020 Mar 24. Epub 2020 Mar 24.

Department of Otorhinolaryngology and Head & Neck Surgery, Gazi University School of Medicine, Beşevler, 06500, Ankara, Turkey.

Purpose: The aim of this study is to evaluate prognosis and prognostic factors affecting oncological outcome.

Methods: Records of the subjects managed for a submandibular gland cancer (SGC) between January 1997 and June 2014 were retrospectively reviewed. Survival outcomes were analyzed. Read More

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http://dx.doi.org/10.1007/s00405-020-05924-wDOI Listing

Multimodal Bronchoscopic Treatment of Unresectable Tracheal Adenoid Cystic Carcinoma.

J Bronchology Interv Pulmonol 2020 Apr;27(2):e17-e19

Division of Hematology and Oncology, University of California Irvine, Irvine, CA.

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http://dx.doi.org/10.1097/LBR.0000000000000638DOI Listing

[Treatment of primary craniofacial (sinonasal) malignant tumors affecting the anterior and middle skull base].

Zh Vopr Neirokhir Im N N Burdenko 2020 ;84(1):101-108

Burdenko Neurosurgical Center, Moscow, Russia.

Sinonasal malignant tumors are characterized by high histological variability and complexity of the differential diagnosis. Currently, there are classifications of these tumors, which are based on their localization and involvement of various anatomical structures. However, generally accepted algorithms for treatment of this pathology have not yet been developed. Read More

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http://dx.doi.org/10.17116/neiro202084011101DOI Listing
January 2020

Strain elastography of palatal tumors in conjunction with intraoral ultrasonography, computed tomography, and magnetic resonance imaging: 2 case reports.

Imaging Sci Dent 2020 Mar 17;50(1):73-79. Epub 2020 Mar 17.

Department of Pathology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan.

Computed tomography (CT) and magnetic resonance imaging (MRI) can be useful for the evaluation of palatal lesions, and strain elastography (performed together with intraoral ultrasonography) is a relatively new sonographic imaging modality. This report describes 2 clinical cases in which strain elastography was used to assess palatal tumors in conjunction with intraoral ultrasonography, CT, and MRI. In the first case, diagnosed as a myoepithelioma, the strain was determined to be 0. Read More

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http://dx.doi.org/10.5624/isd.2020.50.1.73DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078409PMC

INSM1 expression in a subset of thoracic malignancies and small round cell tumors: rare potential pitfalls for small cell carcinoma.

Mod Pathol 2020 Mar 12. Epub 2020 Mar 12.

Department of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.

INSM1 is a diagnostic marker for neuroendocrine tumors originating in multiple anatomic sites. In the lung, INSM1 shows 76-97% sensitivity for neuroendocrine tumors overall. Our aim was to characterize INSM1 as a diagnostic marker for small cell carcinoma in the context of its epithelial, lymphoid, and mesenchymal morphologic mimics. Read More

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http://dx.doi.org/10.1038/s41379-020-0517-0DOI Listing

Basaloid squamous cell carcinoma of the breast.

Rev Esp Patol 2020 Apr - Jun;53(2):113-116. Epub 2020 Jan 14.

Department of Pathology, Hospital Quironsalud Barcelona, Spain; Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain; Infections and Cancer Unit, Cancer Epidemiology Research Program, IDIBELL, Institut Català d'Oncologia (ICO)-IDIBELL, CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain.

Basaloid squamous cell carcinoma (BSCC) is a subtype of squamous cell carcinoma that characteristically occurs in the head and neck, may be related to HPV infection and is usually considered to be aggressive. We present the first description of BSCC of the breast. The tumor exhibited characteristic histologic features of BSCC, including nests of basaloid squamous cells with comedonecrosis, abrupt keratinization, and abundant hyaline basement membrane-like material deposition. Read More

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http://dx.doi.org/10.1016/j.patol.2019.10.003DOI Listing
January 2020

GOLT1A-KISS1 fusion is associated with metastasis in adenoid cystic carcinomas.

Biochem Biophys Res Commun 2020 May 17;526(1):70-77. Epub 2020 Mar 17.

Department of Pharmacology, Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address:

Genetic alterations can drive carcinogenesis. Numerous studies have shown that gene fusion is associated with cancer progression and could provide valuable biomarkers for clinical diagnosis or targets for cancer therapy. Adenoid cystic carcinoma (ACC) is a rare form of adenocarcinoma, characterized by frequent local recurrence and high rates of distant metastasis, ultimately resulting in low survival rates. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.03.005DOI Listing
May 2020
2.297 Impact Factor

Primary intraosseous adenoid cystic carcinoma of the mandible: A rare clinical entity.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S42-S45. Epub 2020 Feb 28.

Department of Oral Pathology and Microbiology, Subharti Dental College and Hospital, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India.

Central intraosseous adenoid cystic carcinoma (ACC) of the mandible, formerly known as cylindroma, is a rare neoplasm with only 47 cases reported in the literature. We present a case of central ACC involving the mandible of a 55-year-old male patient. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_11_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069143PMC
February 2020

Intraosseous adenoid cystic carcinoma of the mandible: A rare presentation.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S37-S41. Epub 2020 Feb 28.

Commandant, Armed Forces Dental Clinic, New Delhi, India.

Central adenoid cystic carcinoma (ACC) of the mandible is a rare entity arising from minor salivary glands. Their clinical and radiographic features may be similar to any odontogenic/nonodontogenic pathology, thus making their precise diagnosis wearisome. ACC is well documented for its protracted clinical course, perineural invasion, multiple recurrence rates and its propensity for distant metastases. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_19_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069154PMC
February 2020

Recurrent adenoid cystic carcinoma of paranasal sinuses: A rare case report.

J Oral Maxillofac Pathol 2020 Feb 28;24(Suppl 1):S28-S32. Epub 2020 Feb 28.

Department of Oral Pathology and Microbiology, Mamata Dental College, Khammam, Telangana, India.

Adenoid cystic carcinoma (ACC) is a distinct salivary gland neoplasm that predominantly occurs in the minor salivary gland. ACC is an uncommon tumor that progress slowly affecting 5% of paranasal sinuses with high distant metastasis rate in advance stages. This salivary gland tumor is difficult to diagnose both clinically and histopathologically due to its indolent presentation and diverse histopathological patterns. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_10_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069138PMC
February 2020

Fine-needle aspiration cytology for the diagnosis of solid basaloid adenoid cystic carcinoma of the breast: Its role, limitation, and perspective.

Diagn Cytopathol 2020 Mar 17. Epub 2020 Mar 17.

Department of Diagnostic Pathology, Kaizuka City Hospital, Osaka, Japan.

Solid basaloid adenoid cystic carcinoma (SB-AdCC) is a subtype of breast AdCC which shows more aggressive clinical behavior than other subtypes. Fine-needle aspiration (FNA) cytology is a useful diagnostic tool for breast malignancies. However, most of the diagnostic cytological characteristics of AdCC are not present in SB-AdCC and cytomorphological studies of this subtype are limited. Read More

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http://dx.doi.org/10.1002/dc.24414DOI Listing

C6-ceramide induces salivary adenoid cystic carcinoma cell apoptosis via IP3R-activated UPR and UPR-independent pathways.

Biochem Biophys Res Commun 2020 May 13;525(4):997-1003. Epub 2020 Mar 13.

Department of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, No. 14, Section Three, Ren Min Nan Road, Chengdu, Sichuan, 610041, China. Electronic address:

C6-ceramide is an exogenous short-chain ceramide which can induce apoptosis of multiple cancer cells. Salivary adenoid cystic carcinoma (SACC) is a common salivary gland cancer, which possesses of high rate of local recurrence and distant metastasis. The mechanism of ceramide-induced SACC-83 and SACC-LM cell apoptosis has not been revealed. Read More

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http://dx.doi.org/10.1016/j.bbrc.2020.02.164DOI Listing

Late intracranial metastasis from adenoid-cystic carcinoma of the parotid gland: Imaging, histologic and molecular features.

Curr Probl Cancer 2020 Mar 5:100564. Epub 2020 Mar 5.

Department of Oncology, Fondazione Poliambulanza Hospital, Brescia, Italy. Electronic address:

We describe the neuroradiologic, histologic, and genetic features of a very unusual intracranial dural metastasis from adenoid cystic carcinoma of the parotid gland detected 27 years after the initial diagnosis. Read More

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http://dx.doi.org/10.1016/j.currproblcancer.2020.100564DOI Listing

A prospective multicentre REFCOR study of 470 cases of head and neck Adenoid cystic carcinoma: epidemiology and prognostic factors.

Eur J Cancer 2020 May 11;130:241-249. Epub 2020 Mar 11.

Sorbonne University, APHP, Department of ENT-Head and Neck Surgery, Tenon Hospital, 4 Rue de La Chine, 75020, Paris, France. Electronic address:

Background: Adenoid cystic carcinoma (ACC) accounts for 1% of malignant head and neck tumours [1] and 10% of salivary glands malignant tumours. The main objective of our study is to investigate the prognostic factors influencing the event-free survival (EFS) of patients with ACC.

Patients And Methods: A multicentre prospective study was conducted from 2009 to 2018. Read More

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http://dx.doi.org/10.1016/j.ejca.2020.01.023DOI Listing
May 2020
5.417 Impact Factor

HPV-Related Multiphenotypic Sinonasal Carcinoma: A Case Report and Literature Review.

Laryngoscope 2020 Mar 11. Epub 2020 Mar 11.

Department of Otolaryngology, San Antonio Military Medical Center, San Antonio, Texas, U.S.A.

Objectives: Human papilloma virus-related multi phenotypic sinonasal carcinoma (HMSC), a recently characterized sinonasal malignancy, is discussed including histology, clinical presentation, and treatment outcomes.

Study Design: Case report with literature review.

Methods: A case of HMSC is reported, as well as a retrospective review of all cases of HMSC reported in the English literature from January 2000 through May 2018 in the MEDLINE, EMBASE, and Scopus databases. Read More

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http://dx.doi.org/10.1002/lary.28598DOI Listing

Malignant cylindroma of the scalp treated with staged perimeter excision: A case report and literature review.

JPRAS Open 2019 Sep 24;21:1-5. Epub 2019 Apr 24.

Department of Plastic and Reconstructive Surgery, Schulich School of Medicine & Dentistry, Western University, Canada.

Malignant cylindroma is a rare and poorly understood cutaneous malignancy. There is a paucity of literature on these lesions, with only a select number of case reports and limited guidelines on management. We present a case of a 60-year old patient with a malignant cylindroma of the scalp treated surgically with staged perimeter excision and summarize our review of the literature with a focus on management of this potentially aggressive disease. Read More

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http://dx.doi.org/10.1016/j.jpra.2019.04.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7061669PMC
September 2019

Risk factors for survival and distant metastasis in 125 patients with head and neck adenoid cystic carcinoma undergoing primary surgery.

J Cancer Res Clin Oncol 2020 May 6;146(5):1343-1350. Epub 2020 Mar 6.

Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.

Purpose: Adenoid cystic carcinoma (AdCC) is generally slow growing but has highly metastatic potential to distant organs. Several factors and biomarkers are associated with metastasis and treatment outcomes, although further definition is needed. Therefore, this study aimed to evaluate the risk factors for survival and distant metastasis in patients with head and neck AdCC. Read More

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http://dx.doi.org/10.1007/s00432-020-03170-5DOI Listing

The current markers of cancer stem cell in oral cancers.

Life Sci 2020 May 3;249:117483. Epub 2020 Mar 3.

Nanotechnology and Regenerative Medicine Commercialization Centre (Ltd), London Bioscience Innovation Centre, London, UK.

Head and neck cancer (HNC) constitute 5% of all reported cancers. Among all, the oral cavity cancer is the most frequent type of HNC which accounts for over half of HNC cases. Mouth cancer ranks the sixth leading cause of cancer-related mortality. Read More

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http://dx.doi.org/10.1016/j.lfs.2020.117483DOI Listing
May 2020
2.702 Impact Factor