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    Genetic Characterization of Adenoid Cystic Carcinoma of the Minor Salivary Glands: A Potential Familial Occurrence in First-Degree Relatives.
    Head Neck Pathol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, 2100, Copenhagen, Denmark.
    Adenoid cystic carcinoma (AdCC) is a malignant salivary gland tumor. To date, no cases of AdCC in first-degree relatives have been reported in the literature. We present a 50-year-old female (Case 1) and this patients' father (Case 2), both of whom were diagnosed with AdCC of the minor salivary glands. Read More

    Cytokeratin immunoprofile of primary and metastatic adenoid cystic carcinoma of salivary glands: a report of two cases.
    Autops Case Rep 2016 Oct-Dec;6(4):57-63. Epub 2016 Dec 30.
    Department of Stomatology - Dental School - Universidade de São Paulo, São Paulo/SP - Brazil .
    Distant metastases from salivary gland tumors are considered infrequent: the incidence of distant metastases ranges from 24% to 61% according to different histotypes and to the site of the primary mass. The most common site of distant metastases due to salivary gland malignancies is the lung. From the pathology point of view, cytokeratins (CK) are important differentiation markers in salivary gland tumors, which are often used for the diagnostic process. Read More

    Prognostic significance of p53 immunohistochemical expression in adenoid cystic carcinoma of the salivary glands: a meta-analysis.
    Oncotarget 2017 Feb 11. Epub 2017 Feb 11.
    Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, Zhejiang Province, China.
    Adenoid cystic carcinoma of salivary glands is a rare adenocarcinoma and has been placed in "high-risk" category as poor long-term prognosis. The purpose of this study was to investigate p53 protein expression in adenoid cystic carcinoma of salivary glands and its correlation with clinicopathological parameters and prognosis. Literatures were searched from PubMed, Embase, Cochrane Library and Web of Science, which investigated the relationships between p53 expression and pathological type, clinical stage, local recurrence, metastasis, nerve infiltration and overall survival. Read More

    Cribriform adenocarcinoma of the minor salivary gland arising in the tonsil with metastasis to a cervical lymph node: A case report with description of fine needle aspiration cytology.
    Diagn Cytopathol 2017 Feb 16. Epub 2017 Feb 16.
    Department of Pathology, University of Kansas School of Medicine, Kansas City, Kansas, 66160.
    Cribriform adenocarcinoma of minor salivary gland (CAMSG) is a rare tumor of the head and neck. We report a case of a 70-year-old female who presented with a 4-5-month history of a left neck mass. CT scan of the neck showed a left neck mass just inferior to the angle of the mandible and left tonsillar prominence. Read More

    Patterns of care and survival of adjuvant radiation for major salivary adenoid cystic carcinoma.
    Laryngoscope 2017 Feb 14. Epub 2017 Feb 14.
    Department of Radiation Oncology, SUNY Downstate Medical Center, Brooklyn, New York.
    Objectives/hypothesis: National Cancer Care Network guidelines suggest consideration of adjuvant radiation even for early stage adenoid cystic carcinoma of the salivary glands. We used the National Cancer Data Base (NCDB) to analyze practice patterns and outcomes of postoperative radiotherapy for adenoid cystic carcinomas.

    Study Design: Retrospective NCDB review. Read More

    Primary Intraosseous Adenoid Cystic Carcinoma of the Mandible: A Comprehensive Review With Analysis of 2 Additional Cases.
    J Oral Maxillofac Surg 2017 Jan 18. Epub 2017 Jan 18.
    Department of Oral Radiology, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China.
    Purpose: Primary intraosseous adenoid cystic carcinoma (IACC) of the mandible is poorly understood because of its rarity. This study performed a comprehensive literature review on IACC of the mandible.

    Materials And Methods: Forty-five cases of IACC reported in the literature and 2 additional cases in the authors' hospital were reviewed. Read More

    HIF1α in Tumorigenesis of Adenoid Cystic Carcinoma.
    Anticancer Res 2017 02;37(2):599-606
    Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Republic of Korea
    Background: Tumor hypoxia induces hypoxia-inducible factor-1α (HIF1α), which can influence tumorigenesis and metastasis. We evaluated the expression of HIF1α and the effect of HIF1α inhibitors in adenoid cystic carcinoma (ACC).

    Materials And Methods: HIF1α expression was demonstrated in ACC cell lines (ACC2 and ACCM). Read More

    Adenoid cystic carcinoma of the base of tongue: A population-based study.
    Am J Otolaryngol 2017 Jan 18. Epub 2017 Jan 18.
    Department of Otolaryngology, Head & Neck and Skull Base Surgery, Boston Medical Center, Boston, MA, United States. Electronic address:
    Background: The objective was to assess demographic and survival patterns in patients with adenoid cystic carcinoma of the base of tongue.

    Methods: Patients were extracted from the Surveillance, Epidemiology and End Results (SEER) database from 1973 through 2012 and were categorized by age, gender, race, historical stage A, and treatment. Incidence and survival were compared with Kaplan Meier curves and mortality hazard ratios. Read More

    Endoscopy-Assisted Transoral Versus Endoscopy-Assisted Transcervical Minimal Incision Plus Mandibular Osteotomy Approach in Resection of Large Parapharyngeal Space Tumors.
    J Craniofac Surg 2017 Feb 6. Epub 2017 Feb 6.
    Department of Oral and Maxillofacial Surgery, Sun Yet-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
    Background: Resection of the parapharyngeal space is often challenging. This study aims to evaluate the outcome of the endoscopy-assisted transoral approach for resection of the parapharyngeal space tumors compared with the endoscopy-assisted transcervical approach.

    Methods: Twenty-three consecutive patients (15 males, 8 females) who underwent resection of large parapharyngeal space tumors via endoscopy-assisted transoral (ETO) approach or endoscopy-assisted transcervical minimal incision plus osteotomy of the vertical ramus outside the mandibular foramen (ETC + MO) approach were analyzed retrospectively. Read More

    Risk of Nodal Metastasis in Major Salivary Gland Adenoid Cystic Carcinoma.
    Otolaryngol Head Neck Surg 2017 Feb 1:194599817690138. Epub 2017 Feb 1.
    1 Department of Otolaryngology-Head and Neck Surgery, School of Medicine, Stanford University, Stanford, California, USA.
    Objective To determine the risk of nodal metastasis, examine risk factors for nodal metastasis, and evaluate the impact of nodal metastasis on survival in patients with major salivary gland adenoid cystic carcinoma. Study Design Retrospective cohort study from a large population- based cancer database. Methods Data were extracted from the SEER 18 database (Surveillance, Epidemiology, and End Results) of the National Cancer Institute. Read More

    Elevated TARP promotes proliferation and metastasis of salivary adenoid cystic carcinoma.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Dec 7. Epub 2016 Dec 7.
    The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) and Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, P. R. China. Electronic address:
    Objective: This study aims to analyze the expression of T-cell receptor γ chain alternate reading frame protein (TARP) in salivary adenoid cystic carcinoma (SACC) and its distant metastases and to investigate its influences on the development and progression of SACC.

    Study Design: TARP expression was analyzed in 50 primary SACCs, 13 specimens of metastatic adenoid cystic carcinoma of salivary gland origin, and 20 noncancerous tissues around SACC via immunohistochemistry. Cell Counting Kit-8 tests, wound healing assay, and Transwell experiments were performed to evaluate the effects of lentivirus-mediated TARP overexpression on the proliferation, migration, and invasion of SACC cells. Read More

    Clinical outcomes and prognostic factors of salivary gland adenoid cystic carcinomas: a case control study.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2016 Dec 7. Epub 2016 Dec 7.
    Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou, China.
    Objective: To determine whether there was any difference in the clinical and pathologic features, management, and survival outcomes based on tumor site for salivary adenoid cystic carcinoma (ACC).

    Study Design: This study is a retrospective chart review of 63 salivary ACC patients. These patients were subclassified into 2 groups, the minor salivary glands group (MiSGG) and the major salivary glands group (MaSGG). Read More

    Human Papillomavirus-Associated Neoplasms of the Head and Neck.
    Surg Pathol Clin 2017 Mar 29;10(1):35-55. Epub 2016 Dec 29.
    Department of Pathology, University of Michigan Health System, 2G332 UH, 1500 East Medical Center Drive, Ann Arbor, MI 48109-5054, USA. Electronic address:
    Human papillomavirus (HPV) is an essential causal factor in a subset of head and neck neoplasms, most notably oropharyngeal squamous cell carcinoma, for which HPV infection has important diagnostic, prognostic, and therapeutic implications. This article summarizes the current understanding of HPV-associated neoplasms of the head and neck, including the recently described carcinoma with adenoid cystic-like features. Salient clinical, gross, and microscopic features are discussed, and the utility of specific ancillary studies is highlighted. Read More

    Cytokeratin-14 contributes to collective invasion of salivary adenoid cystic carcinoma.
    PLoS One 2017 2;12(2):e0171341. Epub 2017 Feb 2.
    State Key Laboratory of Oral Diseases West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China.
    Collective invasion of cells plays a fundamental role in tissue growth, wound healing, immune response and cancer metastasis. This paper aimed to investigate cytokeratin-14 (CK14) expression and analyze its association with collective invasion in the invasive front of salivary adenoid cystic carcinoma (SACC) to uncover the role of collective invasion in SACC. Here, in the clinical data of 121 patients with SACC, the positive expression of CK14 was observed in 35/121(28. Read More

    Risk factors and prognosis for salivary gland adenoid cystic carcinoma in southern china: A 25-year retrospective study.
    Medicine (Baltimore) 2017 Feb;96(5):e5964
    aDepartment of Oral and Maxillofacial Surgery, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou bDepartment of Oral and Maxillofacial Surgery, Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai cDepartment of Pathology, The First Affiliated Hospital, Sun Yat-sen University dSun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong eDivision of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China.
    Adenoid cystic carcinoma (ACC) is characterized by slow growth, frequent local recurrences, and high incidence of distant metastasis (DM). The aim of this study was to evaluate predictive factors for local-regional (LR) recurrence, DM, and survival in ACC.A retrospective review of the medical records for patients with salivary glands ACC from 1990 to 2015 was performed. Read More

    Definitive radiotherapy for inoperable adenoid cystic carcinoma of the trachea: A rare case report.
    Lung India 2017 Jan-Feb;34(1):73-75
    Department of Radiation Oncology, Sri Aurobindo Medical College and PG Institute, Indore, Madhya Pradesh, India.
    Adenoid cystic carcinoma (ACC) of the trachea is rare; it represents 1% of all respiratory tract cancers. It is generally considered as a slow-growing, with prolonged clinical course. Most patients present with dyspnea, and the symptoms often mimic those of asthma or chronic bronchitis. Read More

    Immunohistochemical and molecular profile of salivary gland cancer in children.
    Pediatr Blood Cancer 2017 Jan 31. Epub 2017 Jan 31.
    Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
    Background: Pediatric salivary gland carcinomas (SGCs) are very rare. They differ from the adult SGCs in terms of epidemiologic and clinical behavior, being generally limited only to selected histotypes (e.g. Read More

    Locoregional control of tongue base adenoid cystic carcinoma with primary resection and radial forearm free flap reconstruction.
    Ear Nose Throat J 2017 Jan;96(1):37-40
    Department of Otolaryngology, Lahey Clinic, Boston, MA, USA.
    Adenoid cystic carcinoma of the minor salivary glands can be challenging and marked by high rates of local recurrence despite appropriate surgical resection. Management of this pathology in the base of the tongue is particularly difficult given the poor functional outcomes traditionally associated with an aggressive surgical approach. This article presents a case series of patients who underwent up-front surgical resection followed by free tissue transfer reconstruction. Read More

    Adenoid Cystic Carcinoma of Bartholin's Gland: Case Report.
    Acta Med Iran 2016 Dec;54(12):820-822
    Department of Obstetrics, Gynecology and Reproductive Medicine, Loma Linda University Medical Center, Loma Linda, California, USA.
    Primary adenoid cystic carcinoma (ACC) of Bartholin's gland is a rare gynecologic malignancy. We report a case of locally advanced ACC of Bartholin's gland. A 62-year-old presented with left Bartholin's gland carcinoma and underwent left radical vulvectomy, left-sided inguinal-femoral lymph node dissection, posterior pelvic exenteration, and pedicle abdominal muscle flap. Read More

    Definitive proton beam therapy for adenoid cystic carcinoma of the nasopharynx involving the base of skull.
    Oral Oncol 2017 Feb 23;65:38-44. Epub 2016 Dec 23.
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. Electronic address:
    Objectives: Management of unresectable adenocystic carcinoma (ACC) of the nasopharynx is challenging given the high dose required for tumor control while respecting dose constraints. We evaluated long-term outcomes and toxicity in patients with unresectable ACC of the nasopharynx treated with definitive proton beam therapy.

    Methods: Between 2000 and 2013, 14 patients with ACC of the nasopharynx were treated. Read More

    Adenoid cystic carcinoma evaluation and management: progress with optimism!
    Curr Opin Otolaryngol Head Neck Surg 2017 Jan 18. Epub 2017 Jan 18.
    Department Otorhinolaryngology, Head and Neck Surgery, Nottingham University Hospitals, Queens Medical Centre Campus, Nottingham, UK.
    Purpose Of Review: Adenoid cystic carcinoma (ACC) when diagnosed presents several diagnostic and treatment challenges. The standard treatment of surgery and postoperative radiotherapy has remained the standard of care for the past 3 decades. The purpose of this review is to update what's been reported and what's new since the last review in 2004. Read More

    Clinical trial of nintedanib in patients with recurrent or metastatic salivary gland cancer of the head and neck: A multicenter phase 2 study (Korean Cancer Study Group HN14-01).
    Cancer 2017 Jan 19. Epub 2017 Jan 19.
    Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
    Background: Salivary gland cancers (SGCs) are uncommon and account for less than 5% of all head and neck cancers, but they are histologically heterogeneous. No specific therapy, including targeted agents, has consistently improved clinical outcomes in recurrent/metastatic SGC. Recent studies suggest that vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) play important roles in SGC. Read More

    MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors.
    J Cutan Pathol 2017 Jan 18. Epub 2017 Jan 18.
    Departments of Dermatology and Pathology, University of California, San Francisco, California.
    Background: Elevated MYB expression has been documented in adenoid cystic carcinoma (ACC), cylindroma, and spiradenoma, but the specificity of this finding is unknown. CD117 and SOX-10 expression also occurs in some cutaneous adnexal tumors. This study assesses MYB, CD117 and SOX-10 expression in cutaneous adnexal tumors. Read More

    Primary intraosseous adenoid cystic carcinoma of the mandible: a comprehensive review and analysis of four new cases with emphasis on morphologic, immunophenotypic, and molecular characteristics.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Mar 11;123(3):365-373. Epub 2016 Nov 11.
    Department of Oral Pathology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address:
    Objective: To comprehensively review the clinical manifestations, imaging, diagnosis, treatment, and pathologic features of primary intraosseous adenoid cystic carcinoma (PIACC) of the mandible and analyze PIACC histopathology and molecular features in four cases.

    Study Design: We reviewed the literature and retrospectively studied four cases of PIACC.

    Results: The clinical and imaging findings of PIACC are similar to other malignant or borderline-malignant mandible tumors. Read More

    Using Bar and Ball Attachments in Maxillary and Mandibular Implant-Supported Overdentures in a Patient with Adenoid Cystic Carcinoma Associated with Microstomia: A Clinical Report.
    Int J Prosthodont 2017 Jan/Feb;30(1):66-67
    Many clinical studies and literature reviews have suggested that bar and ball attachments in maxillary and mandibular implant-supported overdentures (ISOs) should be indicated only when there is sufficient interocclusal space (IOS; minimum = 30 mm). The aim of this clinical report was to present the prosthetic rehabilitation of a patient with adenoid cystic carcinoma associated with microstomia due to radiotherapy (IOS = 23 mm). ISOs offer superior retention and greater stability than conventional obturators, so that base extensions were kept to the minimum. Read More

    Adenoid cystic carcinoma of the lacrimal gland is frequently characterized by MYB rearrangement.
    Eye (Lond) 2017 Jan 13. Epub 2017 Jan 13.
    Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, MN, USA.
    PurposeAdenoid cystic carcinoma (ACC) represents ~10-15% of salivary neoplasms and almost universally exhibits a lethal clinical course. ACC is also known to occur in the lacrimal gland. ACC is characterized by its heterogeneous morphology and may demonstrate tubular, cribriform, and/or solid architectural patterns. Read More

    Double stenting with silicone and metallic stents for malignant airway stenosis.
    Surg Today 2017 Jan 11. Epub 2017 Jan 11.
    Division of Surgical Oncology, Department of Translational Medical Sciences, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan.
    For severe malignant airway stenosis, there are several types of commercially available airway stents, and each has its own advantages and disadvantages. We herein describe the safety and efficacy of combination stenting with silicone and metallic stents for patients with extended malignant airway stenosis. Seven patients with malignant airway stenosis were treated via combination stenting with a silicone stent and a metallic stent for extended airway stenosis from the central to peripheral airways. Read More

    Transcription Dynamics Prevent RNA-Mediated Genomic Instability through SRPK2-Dependent DDX23 Phosphorylation.
    Cell Rep 2017 Jan;18(2):334-343
    Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1600-276 Lisboa, Portugal. Electronic address:
    Genomic instability is frequently caused by nucleic acid structures termed R-loops that are formed during transcription. Despite their harmful potential, mechanisms that sense, signal, and suppress these structures remain elusive. Here, we report that oscillations in transcription dynamics are a major sensor of R-loops. Read More

    [Clinicopathologic features of mammary analogue secretory carcinoma of salivary glands].
    Zhonghua Bing Li Xue Za Zhi 2017 Jan;46(1):34-37
    Department of Pathology, Medicine School of Nanjing University/Nanjing Jinling Hospital, Nanjing 210002, China.
    Objective: To investigate the clinicopathological features of mammary analogue secretory carcinoma (MASC) of salivary glands, and its diagnosis, differential diagnosis, immunohistochemistry and molecular pathology. Methods: Seventeen cases of MASC were enrolled, with 9 cases of salivary acinar cell carcinoma and 18 cases of adenoid cystic carcinoma as control groups from Nanjing General Hospital from 1997 to 2014 were included in this retrospective study, combined with immunohistochemistry and molecular detection of ETV6-NTRK3 gene fusion. All cases were histologically reviewed with immunohistochemical staining (EnVision) for S-100 protein, SOX10, GATA3, CD117 expression in each group. Read More

    [Clinicopathologic features of adenoid cystic carcinoma of breast].
    Zhonghua Bing Li Xue Za Zhi 2017 Jan;46(1):25-29
    Department of Pathology, Xijing Hospital, College of Basic Medical Science, the Fourth Military Medical University, Xi'an 710032, China.
    Objective: To investigate the clinicopathologic features and grading of adenoid cystic carcinoma (ACC) of the breast. Methods: Sixteen cases of ACC of the breast were analyzed and graded according to the previous report. Immunohistochemical (IHC) staining was used to detect the immunophenotype, Ki-67 proliferative index and expression of EZH2, and the association with tumor grade and outcome was analyzed. Read More

    Basaloid/blue salivary gland tumors.
    Mod Pathol 2017 Jan;30(s1):S84-S95
    Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
    Basaloid tumors are a common diagnostic problem in salivary gland pathology. However, delineating each of these tumor types is facilitated by an algorithmic approach incorporated by tumor border and cell types. This approach greatly diminishes the challenge of separating polymorphous low-grade adenocarcinoma (PLGA) from adenoid cystic carcinoma (ACC). Read More

    The morphological spectrum of salivary gland type tumours of the breast.
    Pathology 2017 Feb 30;49(2):215-227. Epub 2016 Dec 30.
    Unit of Anatomic Pathology at Bellaria Hospital, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
    Salivary gland like tumours of the breast constitute a wide spectrum of entities each one showing peculiar features and clinical behaviour. They can be subdivided as follows: (1) tumours showing pure myoepithelial cell differentiation, such as pure benign and malignant myoepitheliomas; (2) tumours with mixed epithelial and myoepithelial cell differentiation, such as pleomorphic adenoma, adenomyoepithelioma and adenoid cystic carcinoma; and (3) tumours with pure epithelial cell differentiation, such as acinic cell carcinoma, oncocytic carcinoma, mucoepidermoid carcinoma and polymorphous adenocarcinoma. These tumours share similar features with the salivary gland counterparts, but different clinical behaviour. Read More

    Clinicopathologic and prognostic factors in adenoid cystic carcinoma of head and neck minor salivary glands: A clinical analysis of 130 cases.
    Am J Otolaryngol 2016 Nov 23. Epub 2016 Nov 23.
    Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Capital Medical University, No.1, Dongjiaominxiang Street, Dongcheng District, Beijing 100730, PR China. Electronic address:
    Purpose: This study was to investigate clinicopathologic characteristics and prognostic factors in adenoid cystic carcinoma of head and neck minor salivary glands.

    Materials And Methods: We conducted a retrospective review of 130 patients with adenoid cystic carcinoma of head and neck minor salivary glands that were evaluated between 2000 and 2013 in Beijng Tongren Hospital.

    Results: Five-year overall survival and disease-free survival rates were 80. Read More

    Percutaneous CT-fluoroscopic-guided radioisotope seed placement for the management of adenoid cystic carcinoma of the trachea.
    Brachytherapy 2016 Dec 27. Epub 2016 Dec 27.
    Interventional Radiology, Mission Regional Medical Center, Mission Viejo, CA.
    Purpose: Tracheal and paratracheal malignancies present challenges in radiotherapeutic management due to their proximity to sensitive structures, central location, and because of the potential for catastrophic radiation induced fistula. The use of external beam radiation therapy and intraluminal brachytherapy has a limited number of reports in the literature. We have searched for a technique for treating tracheal and paratracheal malignancies allowing application of a high dose of radiation while minimizing dose to normal tissues. Read More

    Histologic characteristics of thymic adenocarcinomas: Clinicopathologic study of a nine-case series and a review of the literature.
    Pathol Res Pract 2017 Feb 15;213(2):106-112. Epub 2016 Nov 15.
    Department of Radiation Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea.
    Primary thymic adenocarcinoma is an extraordinarily rare malignancy; only 49 cases have been reported in the medical literature to date. Because of its rarity, clinical and pathologic characteristics of thymic adenocarcinoma are unclear. We present nine cases of primary thymic adenocarcinoma and discuss clinicopathologic findings in the context of the existing literature. Read More

    Human Papillomavirus-related Carcinoma with Adenoid Cystic-like Features of the Sinonasal Tract: Clinical and Morphological Characterization of 6 New Cases.
    Histopathology 2016 Dec 30. Epub 2016 Dec 30.
    Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.
    Aims: Human Papillomavirus (HPV) is known as causative for squamous cell carcinoma (SCC) of the oropharynx, but is also not infrequently found in carcinomas of the sinonasal tract. Recently, a subset of these carcinomas was recognized to harbour HPV33 and have a significant morphological overlap with adenoid cystic carcinoma (ACC), a rare and aggressive carcinoma originating in the minor salivary glands. Termed HPV-related carcinoma with ACC-like features, only 9 cases have been reported. Read More

    Adenoid cystic carcinoma of the sublingual gland: A case report.
    Imaging Sci Dent 2016 Dec 20;46(4):291-296. Epub 2016 Dec 20.
    Department of Oral and Maxillofacial Surgery, School of Medicine, Jeju National University, Jeju, Korea.
    Adenoid cystic carcinoma (ACC) of the sublingual gland is an extremely rare neoplasm. The clinicopathological characteristics of ACC are slow-growing swelling with or without ulceration, perineural spread, local recurrence, and distant metastasis. This report describes a 58-year-old male who had a slowly growing swelling without ulceration on the right side of the mouth floor that had been present for 1 month. Read More

    Immunohistochemical Expression of CD56 and ALDH1 in Common Salivary Gland Tumors.
    Iran J Otorhinolaryngol 2016 Nov;28(89):389-397
    Department of Oral and Maxillofacial Pathology, School of Dentistry, Babol University of Medical Sciences, Babol, Iran.
    Introduction: Natural killer (NK) cells, of which CD56 is a specific marker, play an important role in host defense against tumors. Cancer stem cells, of which aldehyde dehydrogenase isoform 1 (ALDH1) is an immunohistochemical marker, are a group of tumorigenic cells which are involved in migration and tumor recurrences. We aimed to evaluate the expression of ALDH1 and CD56 in common salivary gland tumors, as well as their relationship with each other and with a number of clinicopathologic factors. Read More

    Similar outcomes between adenoid cystic carcinoma of the breast and invasive ductal carcinoma: a population-based study from the SEER 18 database.
    Oncotarget 2017 Jan;8(4):6206-6215
    Department of Breast Surgery, Key Laboratory of Breast Cancer, Fudan University Shanghai Cancer Center, Shanghai Medical College, Fudan University, Shanghai, China.
    Adenoid cystic carcinoma of the breast (breast-ACC) is a rare and indolent tumor with a good prognosis despite its triple-negative status. However, we observed different outcomes in the present study. Utilizing the Surveillance, Epidemiology, and End Results (SEER) database, we enrolled a total of 89,937 eligible patients with an estimated 86 breast-ACC cases and 89,851 invasive ductal carcinoma (IDC) patients. Read More

    Definitive carbon-ion radiotherapy for locally advanced parotid gland carcinomas.
    Head Neck 2016 Dec 22. Epub 2016 Dec 22.
    Department of Otolaryngology, Chiba University School of Medicine, Chiba, Japan.
    Background: The purpose of this study was to present our evaluation of the safety and efficacy of carbon-ion radiotherapy (C-ion RT) for locally advanced parotid gland carcinomas.

    Methods: Clinicopathological features and outcomes were evaluated in 46 patients receiving C-ion RT for parotid gland carcinomas.

    Results: Sixteen patients had adenoid cystic carcinoma; 8 had adenocarcinoma, 8 had mucoepidermoid carcinoma, and 14 had other carcinomas. Read More

    Adenoid Cystic Carcinoma of the Breast: A Clinical Case Report.
    Med Arch 2016 Oct 25;70(5):392-394. Epub 2016 Oct 25.
    Department of General Surgery, Ankara University School of Medicine, Ankara, Turkey.
    Introduction: Adenoid cystic carcinoma (ACC) is an uncommon tumor of the breast, accounting for approximately 0.1% to 1% of all breast cancers. It is characterized by rare lymph node involvement and distant metastasis, and associated with a favorable prognosis with excellent survival, despite its triple-negative status. Read More

    Management of salivary gland carcinomas - a review.
    Oncotarget 2017 Jan;8(3):3946-3956
    Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan, Shandong, China.
    Salivary gland carcinomas are a heterogeneous group of tumors with many histological subtypes which occur in both major and minor salivary glands. However, they have a relatively low of incidence. Their rarity limits study size and the ability to perform phase III trials. Read More

    N-RAS expression in patients with salivary adenoid cystic carcinoma: association with clinicopathologic features and prognosis.
    Oral Surg Oral Med Oral Pathol Oral Radiol 2017 Feb 2;123(2):242-248. Epub 2016 Nov 2.
    Department of Otorhinolaryngology and Maxillofacial Oncology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer, Tianjin, China. Electronic address:
    Objective: The aim of this study was to investigate N-RAS expression in patients with salivary adenoid cystic carcinoma (SACC) and to analyze its association with clinicopathologic features and prognosis.

    Study Design: We determined N-RAS expression in SACC tumors via immunohistochemistry and evaluated the association between N-RAS expression and clinicopathologic variables. The disease-free survival (DFS) curves were plotted by using the Kaplan-Meier method. Read More

    Imaging of palatal lumps.
    Clin Radiol 2017 Feb 14;72(2):97-107. Epub 2016 Dec 14.
    Department of Radiology, University College London Hospitals NHS Foundation Trust, 235 Euston Road, London NW1 2BU, UK.
    Palatal tumours are relatively rare and of variable aetiology, rendering radiological evaluation a daunting process for many. A systematic approach to the imaging of a palatal lump is therefore essential. The hard and soft palates are oral cavity and oropharyngeal structures, respectively. Read More

    Adenoid cystic carcinoma of the lacrimal sac: case report.
    Arq Bras Oftalmol 2016 Sep-Oct;79(5):333-335
    Department of Ophthalmology, Costa del Sol Hospital, Marbella, Malaga, Spain.
    Lacrimal sac tumors are rare with a clinical presentation that typically includes obstruction of the lacrimal drainage system and epiphora as the most frequent symptom. Cribriform adenoid cystic carcinoma (ACC) is the most common malignant epithelial tumor of the lacrimal gland and minor salivary glands; however, its occurrence in the lacrimal drainage apparatus is extremely rare. Given the rarity of ACC, definitive diagnosis is almost invariably late conferring a poor prognosis. Read More

    Parotidectomy outcomes, diagnosis and complications on pediatric patients; Twelve years of experiences in a tertiary care center.
    Turk J Pediatr 2016 ;58(2):132-135
    Department of Otolaryngology, Head and Neck Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey.
    The aim of this study is to evaluate parotid masses management in pediatric population. From June 2002 to December 2014, 13 patients under the age of 18 with parotid tumors were treated via surgery at Hacettepe University Department of Otorhinolaryngology. Information on patients' demographics, clinical and histopathologic tumor characteristics and treatment modalities with results was obtained from medical records, retrospectively. Read More

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