7,407 results match your criteria Cylindroma


Molecular features of adenoid cystic carcinoma with an emphasis on microRNA expression.

Authors:
Simon Andreasen

APMIS 2018 Jun;126 Suppl 140:7-57

Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Denmark.

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Systemic therapy in non-conventional cancers of the larynx.

Oral Oncol 2018 Jul 26;82:61-68. Epub 2018 May 26.

Department of Hematology and Medical Oncology, Emory University, 1365 Clifton Road Building C, Atlanta, GA 30322, United States; Winship Cancer Institute, Emory University, 1365 Clifton Road Building C, Atlanta, GA 30322, United States. Electronic address:

Laryngeal cancer (LC) remains a challenging disease to treat. The majority of LCs diagnosed worldwide are squamous cell carcinomas (SCC), and current treatment guidelines are designed to address conventional laryngeal SCC. However, several histologically rare tumor types can originate in the larynx. Read More

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Salivary gland tumors in Veracruz. Experience of two institutions

Rev Med Inst Mex Seguro Soc 2018 Mar-Apr;56(2):148-153

Instituto Mexicano del Seguro Social, Unidad Médica de Alta Especialidad, Hospital de Especialidades No. 14, Departamento de Patología. Veracruz, Veracruz, México

Background: The aim of this paper was to know the epidemiological characteristics of the salivary gland tumors in a Mexican population.

Methods: A descriptive, retrospective and cross-sectional study was performed. All cases of salivary gland tumor were collected in a period of 5 years (2009-2014) in two hospitals of our State, the Hospital General de Veracruz and the Unidad Médica de Alta Especialidad y Hospital de Especialidades No. Read More

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June 2018
1 Read

Dedifferentiated adenoid cystic carcinoma ex pleomorphic adenoma of the parotid.

J Cancer Res Ther 2018 Apr-Jun;14(3):706-708

Department of Pathology, Post Graduate Institute of Medical Education and Research, Dr. RML Hospital, New Delhi, India.

Carcinoma ex pleomorphic adenoma (Ca ex PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma. The most common histological subtype is adenocarcinoma, not otherwise specified, salivary duct carcinoma, mucoepidermoid carcinoma, and adenoid cystic carcinoma (ACC). Few case reports of de novo dedifferentiation in ACC are there in the literature, mostly involving minor salivary glands. Read More

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June 2018
2 Reads

IGFBP2 promotes salivary adenoid cystic carcinoma metastasis by activating the NF-κB/ZEB1 signaling pathway.

Cancer Lett 2018 Jun 6;432:38-46. Epub 2018 Jun 6.

Department of Maxillofacial and Otorhinolaryngological Oncology, Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy, Tianjin Cancer Institute, National Clinical Research Center of Cancer, Tianjin 300060, China. Electronic address:

Metastasis is a major cause of poor prognosis in patients suffered with salivary adenoid cystic carcinoma (SACC), in which many factors are implicated. In this study, we identified that IGFBP2, overexpressed in SACC, correlated positively with perineural invasion or metastasis and indicated worse outcome. Moreover, IGFBP2 overexpression could dramatically improve motility and invasion capacity of SACC cells in vitro. Read More

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June 2018
2 Reads

Detection of high CD44 expression in oral cancers using the novel monoclonal antibody, CMab-5.

Biochem Biophys Rep 2018 Jul 12;14:64-68. Epub 2018 Apr 12.

Department of Antibody Drug Development, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi 980-8575, Japan.

CD44 is a transmembrane glycoprotein that regulates a variety of genes related to cell-adhesion, migration, proliferation, differentiation, and survival. A large number of alternative splicing isoforms of CD44, containing various combinations of alternative exons, have been reported. CD44 standard (CD44s), which lacks variant exons, is widely expressed on the surface of most tissues and all hematopoietic cells. Read More

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Histologic heterogeneity of triple negative breast cancer: A National Cancer Centre Database analysis.

Eur J Cancer 2018 Jun 2;98:48-58. Epub 2018 Jun 2.

Department of Radiation Oncology, H. Lee Moffitt Cancer Center & Research Institute, USA. Electronic address:

Background: Triple negative breast cancer (TNBC) is an aggressive disease, but recent studies have identified heterogeneity in patient outcomes. However, the utility of histologic subtyping in TNBC has not yet been well-characterised. This study utilises data from the National Cancer Center Database (NCDB) to complete the largest series to date investigating the prognostic importance of histology within TNBC. Read More

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A Comparative Study of Primary Adenoid Cystic and Mucoepidermoid Carcinoma of Lung.

Front Oncol 2018 15;8:153. Epub 2018 May 15.

Department of Hematology and Oncology, Yuma Regional Medical Center Cancer Center, Yuma, AZ, United States.

Background: Pulmonary mucoepidermoid carcinoma (PMEC) and pulmonary adenoid cystic carcinoma (PACC) are the two major types of primary salivary gland-type (PSGT) lung cancers. The demographic profile, clinicopathological features, and predictors of survival as an overall group have not been described for PSGT cancers of lung.

Methods: In this study, we analyzed demographic, clinical, and survival data from 1,032 patients (546 PMEC and 486 PACC) who were diagnosed of PSGT lung cancer in the Surveillance, Epidemiology and End Results database from 1973 to 2014. Read More

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May 2018
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Immunohistochemical Expression of CD-117 (c-KIT), P-53 and Ki-67 in Adenoid Cystic Carcinoma of Palate.

J Coll Physicians Surg Pak 2018 Jun;28(6):S130-S132

Department of Oral and Maxillofacial Pathology, NIMS Dental College, Jaipur, India.

Adenoid cystic carcinoma (ACC) is a malignant tumor of salivary glands characterized histopathologically by biphasic epithelial tumor comprised of myoepithelial and ductal cells. There is a paucity of the literature regarding the immunohistochemical labelling of ACC arising in minor salivary glands. This paper reports an additional case of palatal ACC with an emphasis on its immunohistochemical staining using three different markers. Read More

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Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival.

Lung Cancer 2018 Jul 30;121:41-47. Epub 2018 Apr 30.

Department of Internal Medicine, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.

Introduction: Adenoid cystic carcinoma (ACC) of the trachea lacks of well-characterized molecular markers. There is currently no specific treatment for metastatic ACC of the trachea. This study aimed to identify genomic mutations of Notch pathway and investigate the efficacy of NOTCH inhibitor in ACC of the trachea. Read More

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Accessory lacrimal gland tumours of the eye region.

Acta Ophthalmol 2018 May 31. Epub 2018 May 31.

Department of Ophthalmology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

Purpose: Tumours of the accessory lacrimal glands (ALGs) are rare and need to be differentiated from other tumours involving the eyelids and caruncle. We report on a consecutive series of patients with ALG tumours and describe the clinical characteristics.

Methods: A retrospective case series including all patients who were operated for ALG tumours at two different centres. Read More

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Effects of para-toluenesulfonamide intratumoral injection on pulmonary adenoid cystic carcinoma complicating with severe central airway obstruction: a 5-year follow-up study.

J Thorac Dis 2018 Apr;10(4):2448-2455

State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China.

Pulmonary adenoid cystic carcinoma (ACC) is a rare type of non-small cell lung carcinoma that may develop life-threatening severe malignant airway obstruction (SMAO). Currently, limited therapeutic approaches exist for ACC-SMAO. We investigated the efficacy and safety of para-toluenesulfonamide (PTS) intratumoral injection for ACC-SMAO. Read More

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A gland of diverse pathology and unpredictable behaviour: our experience of primary submandibular gland malignancies.

Int J Oral Maxillofac Surg 2018 May 23. Epub 2018 May 23.

Department of Surgical Oncology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Submandibular gland tumours are relatively uncommon tumours and demonstrate diverse histological types and a variable prognosis. The aim of this study was to analyze our experience with submandibular malignancies over a period of 6 years (January 2009 to December 2015). Patient data from the 6-year period were reviewed retrospectively and 51 patients with submandibular malignancies were identified. Read More

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May 2018
5 Reads

[Effect of facial artery musculo-mucosal flap in reconstructing defects of tongue and mouth floor].

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2017 Apr;31(4):461-464

Departmentof Oral and Maxillofacial Surgery, the Affiliated Hospital of Guilin Medical College, Guilin Guangxi, 541001, P.R.China.

Objective: To explore the effect of facial artery musculo-mucosal (FAMM) flap to reconstruct tongue and floor of mouth defects.

Methods: Between January 2011 and January 2016, 24 cases of tongue and floor of mouth defects were repaired with FAMM flap after tumor resection. There were 16 males and 8 females, aged from 38 to 70 years with an average of 55 years. Read More

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April 2017
2 Reads

[The expression and clinical significance of survivin in salivary gland adenoid cystic carcinoma: a Meta analysis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Jun;31(12):927-931

Department of Oral and Maxillofacial Surgery, College of Stomatology, Guangxi Medical University, Nanning, 530021, China.

This Meta-analysis was performed to explore the association between survivin expression and clinical pathological features of salivary gland adenoid cystic carcinoma (SACC). Literature was searched in some databases such as PubMed, Embase, Cochrane Library, web of science, OVID, Springerlink, CNKI, CBM, Wanfang and CQVIP. The pooled odds ratios () and 95% confidence intervals (95% ) were estimated to determine the correlation between survivin expression and SACC using a fixed or random effects model according to heterogeneity. Read More

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[Immediate reconstruction of facial nerve defect using cable grafting of the greater auricualr nerve after parotid cancer resection].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Aug;31(16):1254-1258

Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu,610041, China.

To evaluate the feasibility of immediate reconstruction of facial nerve defect by using cable grafting of the greater auricular nerve after parotid cancer resection.Clinical data of 11 patients suffering from parotid cancer was reviewed.9 cases were diagnosed as mucoepidermoid carcinoma and 2 cases were adenoid cystic carcinoma. Read More

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[The clinical features and prognosis analysis of adenoid cystic carcinoma in nasal cavity and paranasal sinus].

Authors:
Q Chen Y P Ba

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2017 Nov;31(22):1740-1744

Department of Otorhinolaryngology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

To investigate the clinical features and prognosis of adenoid cystic carcinoma (ACC) in nasal cavity and sinus. 67 patients with ACC were recruited interview in our department from 2007 to 2017. The association between clinical parameters and survival were evaluated by statistical analysis. Read More

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November 2017

Autoimmune Granulomatous Inflammation of Lacrimal Glands and Axonal Neuritis Following Treatment With Ipilimumab and Radiation Therapy.

J Immunother 2018 May 21. Epub 2018 May 21.

Departments of Investigational Cancer Therapeutics.

Immune checkpoint inhibitors such as anti-CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), anti PD-1 (programmed cell death protein 1) and PD-L1 (programmed cell death protein-ligand 1) monoclonal antibodies are emerging as standard oncology treatments in various tumor types. The indications will expand as immunotherapies are being investigated in various tumors with promising results. Currently, there is inadequate identification of predictive biomarkers of response or toxicity. Read More

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May 2018
2 Reads

A Case of Adenoid Cystic Carcinoma Mimicking a Bartholin Cyst and Literature Review.

Case Rep Obstet Gynecol 2018 26;2018:5256876. Epub 2018 Mar 26.

University of Queensland, Brisbane, QLD, Australia.

Adenoid cystic carcinoma of the Bartholin Gland (BG-ACC) is a rare form of vulval cancer with only approximately 350 reported cases since 1864. A review of available literature and case reports suggests an aggressive nature with protracted clinical symptoms and a tendency for local recurrence despite adequate surgical excision with or without adjuvant radiotherapy. Survival rates of 71% and 59% are reported at five and ten years. Read More

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[Advances in the molecular mechanisms of perineural invasion in salivary adenoid cystic carcinoma].

Hua Xi Kou Qiang Yi Xue Za Zhi 2018 Apr;36(2):204-211

State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pathology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Salivary adenoid cystic carcinoma is a very common malignant neoplasm in the salivary glands. One of the most important features of salivary cystic carcinoma is perineural invasion, which renders its complete removal is very difficult through clinical surgery. Consequently, tumor recurrence occurs easily after clinical surgery. Read More

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Liver resection for metastases of tracheal adenoid cystic carcinoma: Report of two cases.

Int J Surg Case Rep 2018 May 16;48:26-29. Epub 2018 May 16.

Department of Surgery, Division of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Japan. Electronic address:

Introduction: Tracheal adenoid cystic carcinoma (ACC) is rare and accounts for <1% of all lung cancers. Although ACC is classified as a low-grade tumor, metastases are frequently identified in the late period. Extrapulmonary metastases are rare, and their resection has rarely been reported. Read More

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May 2018
2 Reads

Recurrence of human papillomavirus-related carcinoma with adenoid cystic-like features.

Acta Otorrinolaringol Esp 2018 May 15. Epub 2018 May 15.

Servicio de Anatomía Patológica, Hospital Universitario Son Espases, Palma de Mallorca, Mallorca, España.

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Complications in Salvage Surgery for Nasal and Paranasal Malignant Tumors Involving the Skull Base.

J Neurol Surg B Skull Base 2018 Jun 14;79(3):224-228. Epub 2017 Sep 14.

Department of Otolaryngology-Head and Neck Surgery, Kobe University Graduate School of Medicine, Kobe, Japan.

 Nasal and paranasal malignant tumors invading the skull base are rare and poorly studied. We evaluated postoperative complications in patients undergoing salvage surgery for such tumors.  Retrospective study. Read More

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miR-93-5p enhance lacrimal gland adenoid cystic carcinoma cell tumorigenesis by targeting BRMS1L.

Cancer Cell Int 2018 9;18:72. Epub 2018 May 9.

Department of Ophthalmology, The First Affiliated Hospital of Harbin Medical University, 194 Xuefu Road, Harbin, 150001 Heilongjiang China.

Background: Lacrimal adenoid cystic carcinoma (LACC) is one of the most common malignancies that affects lacrimal gland. MicroRNAs are known to play a crucial role as oncogenes or tumor suppressors. Specifically, miR-93 has been reported to play a crucial role in colorectal, breast, pancreatic, lung cancer and hepatocellular carcinoma. Read More

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May 2018
2 Reads

Sinonasal adenoid cystic carcinoma-role of on-site FNAC: a case report.

BMC Ear Nose Throat Disord 2018 9;18. Epub 2018 May 9.

Department of Pathology, Seth GSMC & KEMH, Parel, Mumbai, Maharashtra 4900012 India.

Background: Adenoid cystic carcinoma (ACC), a rare tumor of epithelial cell origin, commonly arises from the major salivary glands. Uncommonly it may be found outside the salivary glands and it's especially rare in the nasal cavity.

Case Presentation: A 71-year female had complaints of swelling at the base of nose, Fine needle aspiration (FNA) from the swelling revealed features of adenoid cystic carcinoma; cell block & IHC for CD-117 was positive. Read More

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[Experience of successful rescue from 5 cases of internal carotid artery injury during transnasal endoscopic skull base surgery].

Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018 Apr;53(4):251-256

Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of University of Science of Technology of China, Anhui Provincial Hospital, Hefei 230001, China.

To investigate the cause and urgent management of internal carotid artery injury during transnasal endoscopic skull base surgery. Five cases of internal carotid artery injury encountered during transnasal endoscopic skull base surgery in Department of Otorhinolaryngology Head and Neck Surgery, the First Affiliated Hospital of University of Science of Technology of China, Anhui Provincial Hospital from December 2010 to July 2017 were analysed retrospectively. There were 2 cases of adenoid cystic carcinoma, 1 case of salivary gland-type adenocarcinoma, 1 case of petrous apex cholesterol granulomas and 1 case of squamous carcinoma. Read More

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Primary cutaneous cribriform apocrine carcinoma: Case report and literature review.

Indian J Dermatol Venereol Leprol 2018 May 2. Epub 2018 May 2.

Department of Pathology, Chia-Yi Christian Hospital; Department of Nursing, Chung-Jen College of Nursing, Health Sciences and Management, Chiayi, Taiwan.

Primary cutaneous cribriform apocrine carcinoma is a rare but distinct variant of primary cutaneous apocrine carcinoma and it is considered a low grade malignancy. We herein present a case of primary cutaneous cribriform apocrine carcinoma at the neck of a 26-year-old female. The tumor features a relatively well-circumscribed border and multiple aggregations of mildly pleomorphic epithelial cells with large ovoid nuclei, small nucleoli and abundant eosinophilic cytoplasms. Read More

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Establishment and characterization of a carcinoma-associated fibroblast cell line derived from a human salivary gland adenoid cystic carcinoma.

Cell Commun Adhes 2018 Dec;24(1):11-18

a College of Stomatology , Dalian Medical University , Dalian , China.

Salivary gland adenoid cystic carcinoma (SACC) is one of the most common malignancies in the oral and maxillofacial region. Carcinoma-associated fibroblast (CAF) is an important component in the tumor microenvironment and participates in SACC progression. In this study, we established a CAF cell line derived from a human SACC and named it CAF-SA. Read More

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December 2018
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Genetic rearrangements, hotspot mutations, and microRNA expression in the progression of metastatic adenoid cystic carcinoma of the salivary gland.

Oncotarget 2018 Apr 13;9(28):19675-19687. Epub 2018 Apr 13.

Department of Otorhinolaryngology and Maxillofacial Surgery, Zealand University Hospital, Køge, Denmark.

Adenoid cystic carcinoma (ACC) is among the most common salivary gland malignancies, and is notorious for its unpredictable clinical course with frequent local recurrences and metastatic spread. However, the molecular mechanisms for metastatic spread are poorly understood. This malignancy is known to frequently harbor gene fusions involving , , and , and to have a low mutational burden. Read More

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Immunohistochemical Detection of Proliferative Marker Ki-67 in Benign and Malignant Salivary Gland Tumors.

J Contemp Dent Pract 2018 Apr 1;19(4):375-383. Epub 2018 Apr 1.

Department of Oral Pathology and Microbiology, Aditya Dental College & Hospital, Beed, Maharashtra, India.

Salivary gland tumors are the most histologically heterogeneous group of tumors with the greatest diversity of morphologic features among their cells and tissues. The present study was aimed at assessing the validity of Ki-67, a cell proliferation marker, as a prognostic factor in benign and malignant salivary gland tumors and to study whether it is related to age, sex, anatomical site, and size of the lesion in salivary gland tumors. A retrospective study consisted of benign salivary gland tumors (BSGTs) (n = 15), malignant salivary gland tumors (n = 18), and normal salivary gland parenchyma (n = 15). Read More

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A Phase 1 dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors.

Ann Oncol 2018 May 3. Epub 2018 May 3.

Division of Hematology and Oncology, University of California San Francisco, San Francisco, USA.

Background: Brontictuzumab is a monoclonal antibody that targets Notch1 and inhibits pathway activation. The purpose of this first-in-human study was to determine the maximum tolerated dose (MTD), safety, pharmacokinetics, immunogenicity and preliminary efficacy of brontictuzumab in patients with solid tumors.

Patients Ans Methods: Subjects with selected refractory solid tumors were elegible. Read More

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Potential biological functions of microvesicles derived from adenoid cystic carcinoma.

Oncol Lett 2018 May 20;15(5):7900-7908. Epub 2018 Mar 20.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P.R. China.

Microvesicles (MVs) are secreted by multiple types of tumor cell and are involved in tumor progression and metastasis. The aim of the present study was to explore the effects of MVs derived from salivary adenoid cystic carcinoma (SACC) and to investigate their potential involvement in the pathogenesis of perineural invasion of SACC. MVs were isolated from ACCs cells, and differential gene expression profiles of these MVs were compared with their donor cells to speculate on their biological functions. Read More

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May 2018
1 Read

Impact on clinical follow-up of the Milan System for salivary gland cytology: A comparison with a traditional diagnostic classification.

Cytopathology 2018 May 3. Epub 2018 May 3.

Division of Anatomic Pathology and Histology, Catholic University of Rome, Rome, Italy.

Introduction: No universally accepted classification exists for salivary gland FNA. The proposed Milan System for Reporting Salivary Gland Cytopathology (MSRSGC) offers a uniform classification with management recommendations. We compared FNA diagnoses from a prior study with specific diagnoses with corresponding MSRSGC diagnoses. Read More

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Central airway obstruction caused by adenoid cystic carcinoma in pregnancy: a case report and review of the literature.

Respirol Case Rep 2018 Jul 20;6(5):e00317. Epub 2018 Apr 20.

Department of Respiratory and Sleep Medicine Liverpool Hospital Sydney Australia.

Malignancy complicates one in a thousand pregnancies. The most frequently diagnosed of these are breast, cervical, melanoma, ovarian, and haematological neoplasms. Tumours of respiratory origin are very uncommon during pregnancy. Read More

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July 2018
1 Read

Human Polyomaviruses Are Not Frequently Present in Cancer of the Salivary Glands.

Anticancer Res 2018 05;38(5):2871-2874

Department of Oncology-Pathology, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden

Background/aim: Malignant tumors of the salivary glands are rare and heterogeneous, with more than 20 subtypes, and classified mainly by histopathology. Their diagnosis is often challenging and their etiology unknown. Here, the possible association between human polyomaviruses (PyVs) and one or more salivary gland tumor subtypes was examined. Read More

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May 2018
1 Read

Inhibitory effect of chidamide on the growth of human adenoid cystic carcinoma cells.

Biomed Pharmacother 2018 Mar 20;99:608-614. Epub 2018 Feb 20.

Department of Medical Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. Electronic address:

Adenoid cystic carcinoma (ACC) is a malignant epithelial neoplasm that limitedly responses to chemotherapy at the cost of significant toxicity. There is no single targeted drug approved by Food and Drug Administration (FDA) for ACC. Genomic landscape studies have revealed that frequently mutated pathways in ACC often involve in chromatin remodeling, which interfere multiple histone related proteins. Read More

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Overview of malignant tracheal tumors.

Ann Cardiothorac Surg 2018 Mar;7(2):244-254

Division of Thoracic Surgery, Department of Surgery, Massachusetts General Hospital, Boston, MA, USA.

Malignant airway tumors present particular challenges for surgeons, namely: to distinguish symptoms from those of the more frequent benign airway diseases; to separate metastatic disease from the uncommon primary tumors; and to consider curative resection in appropriate candidates. Here, we present a critical review of tracheal malignant obstruction, focusing on the evaluation of a patient with malignant airway tumor, patient selection for resection and the predictors of long-term survival. The new development in primary tracheal tumors is an old story, that of making physicians aware that resection rates in epidemiologic studies remain low, mainly because opportunities for resection are missed. Read More

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Mortality risk after clinical management of recurrent and metastatic adenoid cystic carcinoma.

J Otolaryngol Head Neck Surg 2018 Apr 25;47(1):28. Epub 2018 Apr 25.

Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.

Background: Management of locoregional recurrence (LRR) and distant metastasis (DM) in adenoid cystic carcinoma (ACC) is guided by limited data. We investigated mortality risks in patients diagnosed and treated for recurrent ACC.

Methods: A retrospective review of ACC patients treated from 1989 to 2016 identified 36 patients with LRR or DM. Read More

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[Retrospective analysis of 896 cases of parotid gland tumor].

Shanghai Kou Qiang Yi Xue 2017 Dec;26(6):605-609

Shengjing Hospital of China Medical University. Shenyang 110004, Liaoning Province, China.

Purpose: To review the clinical data of patients undergoing operation, in order to summarize the incidence, proportion, clinical examination and diagnostic methods of parotid tumors.

Methods: Eight hundred and ninty-six cases of parotid gland tumors were collected from 2008 January to 2015 July from department of oral and maxillofacial surgery in Shengjing Hospital of China Medical University. A retrospective study of the clinical data was carried out, including age, gender, tumor location, diagnostic methods and pathological results. Read More

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December 2017
1 Read

[Cytologic diagnosis of adenoid cystic carcinoma of salivary glands and distinction from basal cell adenoma].

Zhonghua Bing Li Xue Za Zhi 2018 Apr;47(4):279-283

Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Head and Neck Molecular Diagnostic Pathology of Beijing, Beijing 100730, China.

To describe the cytologic features of adenoid cystic carcinoma (ADCC) of salivary glands, and to identify distinguishing cytologic features of ADCC and basal cell adenoma (BCA). A retrospective review of cytology smears of 30 cases of ADCC and 12 cases of BCA of salivary glands were performed. All cases were collected from Beijing Tongren Hospital, Capital Medical University from January 2010 to January 2017. Read More

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April 2018
4 Reads

An Autopsy Report of an Adenoid Cystic Carcinoma Arising in the Trachea.

Head Neck Pathol 2018 Apr 23. Epub 2018 Apr 23.

Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

While adenoid cystic carcinoma is a common malignancy to arise within the salivary glands (21.9%) (Kokemueller et al. in Int J Oral Maxillofac Surg 33:25-31, 2004), it is seldom encountered as a tracheal mass and represents < 1% of all lung cancers. Read More

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Mutation analysis of the EGFR pathway genes, and , in salivary gland adenoid cystic carcinoma.

Oncotarget 2018 Mar 30;9(24):17043-17055. Epub 2018 Mar 30.

Department of Pathology and Molecular Diagnostics, Graduate School of Medical Sciences, Nagoya City University, Nagoya, Japan.

Adenoid cystic carcinoma (AdCC), one of the most common salivary gland carcinomas, usually has a fatal outcome. Epidermal growth factor receptor (EGFR) pathway gene mutations are important in predicting a patient's prognosis and estimating the efficacy of molecular therapy targeting the EGFR pathway. In this study of salivary gland AdCC (SAdCC), we looked for gene mutations in family ( and ), and , using a highly sensitive single-base extension multiplex assay, SNaPshot. Read More

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Genome-wide profiles of metastasis-associated mRNAs and microRNAs in salivary adenoid cystic carcinoma.

Biochem Biophys Res Commun 2018 Jun 26;500(3):632-638. Epub 2018 Apr 26.

Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China; Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China. Electronic address:

Salivary adenoid cystic carcinoma (SACC) is often accompanied with poor prognosis due to local recurrence, distant metastasis, and perineural invasion. The mechanism involved in SACC metastasis is not yet fully understood. In this study, we profiled the expression of messenger RNA (mRNA) and microRNA (miRNA) in a SACC cell line, ACC-2, and a highly metastatic SACC cell line, ACC-M, using high-throughput sequencing. Read More

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June 2018
3 Reads

Reassessing the Potential of Myb-targeted Anti-cancer Therapy.

J Cancer 2018 15;9(7):1259-1266. Epub 2018 Mar 15.

Department of Hematology, the Second Xiangya Hospital, Central South University, Changsha, Hunan Province, P.R. China.

Transcription factor MYB is essential for the tumorigenesis of multiple cancers, especially leukemia, breast cancer, colon cancer, adenoid cystic carcinoma and brain cancer. Thus, MYB has been regarded as an attractive target for tumor therapy. However, pioneer studies of antisense oligodeoxynucleotides against which were launched three decades ago in leukemia therapy, were discontinued because of their unsatisfactory clinical outcomes. Read More

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March 2018
4 Reads

Characterisation of DOG-1 Expression in Salivary Gland Tumours and Comparison with Myoepithelial Markers.

Head Neck Pathol 2018 Apr 18. Epub 2018 Apr 18.

Unit of Oral and Maxillofacial Pathology, School of Clinical Dentistry, 19 Claremont Crescent, Sheffield, S10 2TA, UK.

DOG1 is an established diagnostic marker for gastrointestinal stromal tumours (GIST), but has been reported in salivary gland tumours (SGT) as an acinar and intercalated duct marker. However, its specificity and distribution is not well established. The aim of this study was to evaluate the diagnostic utility of DOG-1 expression in SGT in addition to comparing it with myoepithelial markers. Read More

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April 2018
1 Read

Analysis of histologic follow-up and risk of malignancy for salivary gland neoplasm of uncertain malignant potential proposed by the milan system for reporting salivary gland cytopathology.

Cancer Cytopathol 2018 Apr 18. Epub 2018 Apr 18.

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, Arizona.

Background: The Milan System for Reporting Salivary Gland Cytopathology is a tiered classification scheme that includes 6 diagnostic categories. Neoplasm, which is 1 of the 6 proposed categories, consists of benign neoplasm and neoplasm of uncertain malignant potential (NUMP). NUMP is reserved for a salivary gland neoplasm without clear distinction between benign and malignant. Read More

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April 2018
2 Reads

The oncogenic effects of HES1 on salivary adenoid cystic carcinoma cell growth and metastasis.

BMC Cancer 2018 Apr 17;18(1):436. Epub 2018 Apr 17.

Department of Preventive Dentistry, Affiliated Stomatological Hospital, Fujian Medical University, 246 Yang Qiao Middle Road, Fuzhou, 350002, China.

Background: Our previous study demonstrated a close relationship between NOTCH signaling pathway and salivary adenoid cystic carcinoma (SACC). HES1 is a well-known target gene of NOTCH signaling pathway. The purpose of the present study was to further explore the molecular mechanism of HES1 in SACC. Read More

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April 2018
3 Reads

Clinicopathologic analysis of 2736 salivary gland cases over a 11-year period in Southwest China.

Acta Otolaryngol 2018 Apr 14:1-4. Epub 2018 Apr 14.

a Department of Oral and Maxillofacial Surgery , Affiliated Stomatology Hospital of Kunming Medical University , Kunming , China.

Objective: To investigate the epidemiological and clinicopathological characteristics of salivary gland tumors in southwest China in order to provide data for clinical diagnosis and other similar research.

Methods: Between March 2007 and December 2017, 2736 patients with salivary gland tumors were recruited, the clinical and pathological data were retrospectively analyzed.

Results: A total of 2736 patients had a ratio of males to females of about 1. Read More

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April 2018
2 Reads

Adenoid cystic carcinoma of head and neck: A retrospective clinical analysis of a single institution.

Auris Nasus Larynx 2018 Aug 10;45(4):831-837. Epub 2018 Apr 10.

Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan; School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan. Electronic address:

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August 2018
2 Reads