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    Incidentally Discovered Adenoid Cystic Carcinoma of the Lacrimal Gland with Isolated Liver Metastases.
    Ocul Oncol Pathol 2017 Nov 1;3(4):262-266. Epub 2017 Apr 1.
    Washington University School of Medicine, Saint Louis, Missouri, USA.
    Aim: To report a rare presentation of adenoid cystic carcinoma (ACC) of the lacrimal gland.

    Method: This is a case report presenting clinical, radiographic, and histopathologic findings.

    Results: A 72-year-old female with no reported ocular symptoms was found to have an incidental right orbital mass on imaging. Read More

    The Clinicopathological Features and Survival Outcomes of Different Histological Subtypes in Triple-negative Breast Cancer.
    J Cancer 2018 1;9(2):296-303. Epub 2018 Jan 1.
    Department of Radiation Oncology, Xiamen Cancer Hospital, the First Affiliated Hospital of Xiamen University, Xiamen 361003, People's Republic of China.
    Purpose: To determine the clinicopathological features and survival outcomes of triple-negative breast cancer (TNBC) according to different histological subtypes. Methods: Using the Surveillance, Epidemiology, and End Results database, we included TNBC cases in 2010-2013. The effect of histological subtype on breast cancer-specific survival (BCSS) and overall survival (OS) were analyzed using univariate and multivariate analyses. Read More

    Overexpression of CDC7 in malignant salivary gland tumors correlates with tumor differentiation.
    Braz J Otorhinolaryngol 2017 Dec 26. Epub 2017 Dec 26.
    School of Dentistry, Department of Oral and Maxillofacial Pathology, Shiraz University of Medical Sciences, Shiraz, Iran.
    Introduction: Cell division cycle-7 protein is a serine/threonine kinase that has a basic role in cell cycle regulation and is a potential prognostic or therapeutic target in some human cancers.

    Objectives: This study investigated the expression of cell division cycle-7 protein in benign and malignant salivary gland tumors and also its correlation with clinicopathologic factors.

    Methods: Immunohistochemical expression of cell division cycle-7 was evaluated in 46 cases, including 15 adenoid cystic carcinoma, 12 mucoepidermoid carcinoma, 14 pleomorphic adenoma, and 5 normal salivary glands. Read More

    Immunohistochemical Evaluation Of Oestrogen Receptors In Adenoid Cystic Carcinoma Of Salivary Gland.
    J Ayub Med Coll Abbottabad 2017 Oct-Dec;29(4):535-539
    School of Public Health, Xi'an Jiaotong University, Xi'an, China.
    Background: Oestrogen has a physiological role throughout the body including oral cavity. The effects are mediated by binding to two receptors in nucleus alpha and beta, which are ligand-activated transcription factors. The alpha receptors have a prognostic significance in cancer of breast while in Adenoid cystic carcinoma of salivary glands the results are inconsistent. Read More

    Role of miR-21 in the growth and metastasis of human salivary adenoid cystic carcinoma.
    Mol Med Rep 2018 Jan 5. Epub 2018 Jan 5.
    Department of Oral and Maxillofacial Surgery, School of Stomatology, Xuzhou Medical University, Xuzhou, Jiangsu 221000, P.R. China.
    Aberrant microRNA (miRNA/miR) expression has been reported in various cancer types. miR‑21, which is considered to be a proto-oncogene and is frequently overexpressed in certain cancer types, has been implicated in tumorigenesis. The aim of the present study was to investigate the effect of miR‑21 degradation on tumor progression and its potential mechanisms in human salivary adenoid cystic carcinoma (SACC) development. Read More

    Case report: HPV-related carcinoma with adenoid cystic-like features of the sinonasal tract.
    Laryngoscope 2018 Jan 4. Epub 2018 Jan 4.
    Department of Otolaryngology Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, U.S.A.
    Human papillomavirus-related carcinoma with adenoid cystic-like features is a newly described histologic variant of sinonasal tract carcinoma. The implications of this sinonasal malignancy is still being evaluated. There are a limited number of cases reported in the literature, and thus we seek to further characterize this patient population and review the histologic features of this malignancy with the following two cases. Read More

    High-grade transformation/dedifferentiation of an adenoid cystic carcinoma of the minor salivary gland to myoepithelial carcinoma.
    Pathol Int 2017 Dec 29. Epub 2017 Dec 29.
    Department of Pathology and Applied Neurobiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine (KPUM), Kyoto, Japan.
    High-grade transformation (HGT)/dedifferentiation is an unusual phenomenon in salivary gland carcinomas. Here we report a case of adenoid cystic carcinoma (ACC) with HGT/dedifferentiation to myoepithelial carcinoma, occurring in the epipharynx of a 42-year-old woman. The surgically resected tumor was a pedunculated mass, 31 × 25 mm in size, which had two histologically distinct carcinomatous areas, including a high-grade sarcomatoid area composed of pleomorphic spindle cells and an area consisting of low-grade typical ACC. Read More

    Phase II trial of eribulin mesylate in recurrent or metastatic salivary gland malignancies.
    Head Neck 2017 Dec 28. Epub 2017 Dec 28.
    Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, WA.
    Background: This study examined the microtubule inhibitor eribulin in recurrent/metastatic salivary gland cancers (RMSGCs), a disease where no therapeutic standard exists.

    Methods: This phase II clinical trial treated patients with progressive recurrent/metastatic salivary gland cancers with eribulin 1.4 mg/m2 i. Read More

    AKT3 drives adenoid cystic carcinoma development in salivary glands.
    Cancer Med 2017 Dec 28. Epub 2017 Dec 28.
    Department of Physiology, Center of Physiology and Pharmacology, Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
    Salivary gland cancer is an aggressive and painful cancer, but a rare tumor type accounting for only ~0.5% of cancer cases. Tumors of the salivary gland exhibit heterogeneous histologic and genetic features and they are subdivided into different subtypes, with adenoid cystic carcinomas (ACC) being one of the most abundant. Read More

    Deregulation of Nicotinamide N-Methyltransferase and Gap Junction Protein Alpha-1 Causes Metastasis in Adenoid Cystic Carcinoma.
    Anticancer Res 2018 01;38(1):187-197
    Section of Oral & Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
    Background/aim: Adenoid cystic carcinoma (AdCC) is a malignant tumor that occurs in the salivary glands and frequently metastasizes. The aim of this study was to identify factors mediating AdCC metastasis.

    Materials And Methods: We established three AdCC cell lines by orthotropic transplantation and in vivo selection: parental, highly metastatic (ACCS-M-GFP), and lymph node metastatic (ACCS-LN-GFP) cells. Read More

    Regulation of β-Catenin Phosphorylation by PR55β in Adenoid Cystic Carcinoma.
    Cancer Genomics Proteomics 2018 Jan-Feb;15(1):53-60
    Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
    Background/aim: Adenoid cystic carcinoma (AdCC) is a rare cancer of the salivary gland with high risk of recurrence and metastasis. Wnt signalling is critical for determining tumor grade in AdCC, as it regulates invasion and migration. β-catenin dephosphorylation plays an important role in the Wnt pathway, but its underlying molecular mechanism remains unclear. Read More

    Diagnostic accuracy of 18F-FDG PET/CT and MR imaging in patients with adenoid cystic carcinoma.
    BMC Cancer 2017 12 22;17(1):887. Epub 2017 Dec 22.
    Department of Radiation Oncology, University Duisburg-Essen, University Hospital Essen, Hufelandstrasse 55, 45147, Essen, Germany.
    Background: The aim of this study was to evaluate the value of 18F-FDG PET/CT (PET/CT) and MRI for local and/or whole-body restaging of adenoid cystic carcinoma of the head and neck (ACC).

    Methods: Thirty-six patients with ACC underwent conventional MRI of the head and neck and a whole-body PET/CT and were analysed with regards to detection of a local tumor recurrence, lymph node or distant metastases. A consensus interpretation of all available imaging data was used as reference standard. Read More

    Discordant correlation of breast adenoid cystic carcinoma on imaging and pathology: A case report and literature review on surgical management.
    Int J Surg Case Rep 2017 Dec 8;42:196-199. Epub 2017 Dec 8.
    KK Women and Children's Hospital, Breast Department, 100 Bukit Timah Road, 229899, Singapore.
    Introduction: Adenoid cystic carcinomas (ACC) of the breast are extremely rare tumours, accounting for <0.1% of newly diagnosed breast cancer cases. Little data exist regarding the correlation of radiological findings with histology of this rare subtype. Read More

    The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA.
    Cancer 2017 Dec 20. Epub 2017 Dec 20.
    Department of Pathology, Copenhagen University Hospital, Copenhagen, Denmark.
    Background: Polymorphous adenocarcinoma (PAC) of the palatal minor salivary glands, previously known as polymorphous low-grade adenocarcinoma, is the second most common intraoral malignant salivary gland carcinoma after adenoid cystic carcinoma (ACC) and carries an excellent prognosis. Unfortunately, PAC demonstrates cytological overlap with 2 other salivary gland tumors frequently encountered in the same location, namely ACC and pleomorphic adenoma (PA). Recently, the protein kinase D1 (PRKD1) hotspot mutation E710D was demonstrated to be specific for PAC and to be present in the majority of cases. Read More

    [Clinical analysis of cervical lymph node metastasis of cN0 maxillary malignant tumor].
    Beijing Da Xue Xue Bao Yi Xue Ban 2017 Dec;49(6):1050-1054
    Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing 100081, China.
    Objective: To investigate the cervical lymphatic metastasis rates of clinically negative neck lymph node (cN0) maxillary malignant tumors, to compare the cervical lymphatic metastasis rates of the various pathological types, and to provide the reference for the treatment of the neck of the patients with cN0 maxillary malignant tumor.

    Methods: The clinical data of 277 cases with cN0 maxillary malignant tumor, treated in the department of oral and maxillofacial surgery of Peking University School and Hospital of Stomatology from 1990 to 2010, were reviewed. The cervical lymph node metastasis and the related clinical information were recorded. Read More

    Endoscopic submucosal dissection in a patient with esophageal adenoid cystic carcinoma.
    World J Gastroenterol 2017 Dec;23(45):8097-8103
    Division of Gastroenterology and Hepatology, Internal Medicine, Jikei University School of Medicine, Tokyo 105-8471, Japan.
    We report the first use of endoscopic submucosal dissection (ESD) for the treatment of a patient with adenoid cystic carcinoma of the esophagus (EACC). An 82-year-old woman visited our hospital for evaluation of an esophageal submucosal tumor. Endoscopic examination showed a submucosal tumor in the middle third of the esophagus. Read More

    Refractory Facial Paralysis: A Case Report.
    Acta Neurol Taiwan 2017 Jun;26(2):68-71
    Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
    Purpose: To present a case of salivary gland malignancy initially mimicking Bell's palsy.

    Case Report: A 75-year-old woman with hypertension visited our neurological outpatient department,complaining of persistent right facial paralysis for more than a year after oral glucocorticoid therapy with recent development of vertigo and unsteady gait. She was previously diagnosed as having Bell's palsy and was prescribed oral glucocorticoid. Read More

    Study of MYB-NFIB chimeric gene expression, tumor angiogenesis, and proliferation in adenoid cystic carcinoma of salivary gland.
    Odontology 2017 Dec 14. Epub 2017 Dec 14.
    Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Histopathology of Pathogenic Mechanisms, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata, Niigata, 951-8580, Japan.
    Adenoid cystic carcinoma (ACC) is one of the common malignant tumors in salivary glands, and the clinical prognosis is poor with frequent distant metastasis which may lead to death. Expression of the MYB-NFIB chimeric gene in ACC has been reported recently. MYB is an oncogene with transcription regulating functions, and NFIB encodes nuclear transcription factor although detailed functions are unknown. Read More

    68Ga-PSMA PET-CT Imaging of Metastatic Adenoid Cystic Carcinoma.
    Nucl Med Mol Imaging 2017 Dec 16;51(4):360-361. Epub 2016 Aug 16.
    Department of pathology, UMC Utrecht, Utrecht, Netherlands.
    A patient with a history of adenoid cystic carcinoma of the nasal cavity presented himself with bone pain and an elevated PSA level. On suspicion of metastatic prostate cancer a 68Ga-PSMA PET-CT was performed. The PET-CT showed numerous lung and non-sclerotic bone metastasis. Read More

    Small bowel and cecal Involvement: Unusual metastasis sites from adenoid cystic carcinoma of the minor salivary gland.
    J Cancer Res Ther 2017 Oct-Dec;13(6):1070-1072
    Department of Medical Oncology, Faculty of Medicine, Yıldırım Beyazıt University, Ankara, Turkey.
    Adenoid cystic carcinoma (ACC) is a rare neoplasm and the most frequent pathology occurring in the minor salivary glands. Lung, bone, liver, and brain are the most frequent metastasis sites in ACC cases. To our knowledge, cecal and ileum metastasis from ACC has not been previously reported in literature. Read More

    CTNNB1 mutations in basal cell adenoma of the salivary gland.
    J Formos Med Assoc 2017 Dec 7. Epub 2017 Dec 7.
    Department of Pathology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan; Graduate Institute of Pathology, National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:
    Background/purpose: Basal cell adenoma (BCA) and basal cell adenocarcinoma (BCAC) are uncommon salivary gland tumors comprising proliferation of basaloid cells. Nuclear β-catenin expression and mutations in its encoding gene (CTNNB1) are reported to be specific to BCA. PIK3CA mutations are only found in BCAC not in BCA. Read More

    Primary cutaneous secretory carcinoma: A previously overlooked low-grade sweat gland carcinoma.
    J Cutan Pathol 2017 Dec 4. Epub 2017 Dec 4.
    Friedrichshafen Dermatopathologie, Friedrichshafen, Germany.
    Introduction: Twelve cases of primary cutaneous secretory carcinoma (PCSC) have been published, 9 showing ETV6-NTRK3 translocation, a characteristic finding shared with secretory breast carcinoma and mammary analogue secretory carcinoma.

    Case Report: A 34-year-old female presented a solitary nodule on the right groin. Biopsy revealed a secretory carcinoma staining positive with CK7, CAM5. Read More

    Diagnostic accuracy of touch imprint cytology for head and neck malignancies: a useful intra-operative tool in resource limited countries.
    BMC Clin Pathol 2017 25;17:25. Epub 2017 Nov 25.
    Kandahar University, Kandahar, Afghanistan.
    Background: Intraoperative consultation is an important tool for the evaluation of the upper aerodigestive tract (UAT) malignancies. Although frozen section analysis is a preferred method of intra-operative consultation, however in resource limited countries like Pakistan, this facility is not available in most institutes; therefore, we aimed to evaluate the diagnostic accuracy of touch imprint cytology for UAT malignancies using histopathology of the same tissue as gold standard.

    Methods: The study involved 70 cases of UAT lesions operated during the study period. Read More

    A 10-year clinical outcome of radiotherapy as an adjuvant or definitive treatment for primary tracheal adenoid cystic carcinoma.
    Radiat Oncol 2017 Dec 4;12(1):196. Epub 2017 Dec 4.
    Department of Radiation Oncology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul, 05505, South Korea.
    Background: To evaluate the role of radiotherapy (RT) as an adjuvant or definitive treatment in primary tracheal adenoid cystic carcinoma (ACC) for local tumor control and survival.

    Methods: A retrospective chart review was performed in 22 patients treated with adjuvant or definitive RT for primary tracheal ACC at a single center between November 1994 and December 2008.

    Results: Thirteen and 9 patients received adjuvant and definitive RT, respectively. Read More

    [Effect of HBXIP on biological function and PI3K/Akt signaling pathway of adenoid cystic carcinoma cell line ACC-M].
    Shanghai Kou Qiang Yi Xue 2017 Aug;26(4):389-394
    Department of Oral and Maxillofacial Surgery, Shengjing Hospital Affiliated to China Medical University. Shenyang 110004.
    Purpose: To study the effect of hepatitis B virus X protein binding protein (HBXIP) on proliferation, migration and invasion of adenoid cystic carcinoma cell line ACC-M, and the possible mechanism of PI3K/Akt signaling pathway.

    Methods: HBXIP plasmid was transfected into ACC-M. The cells were divided into experimental group (transfected with plasmid pEGFP-N1-HBXIP) control group (non-transfected group) and blank control group (vector group, pEGFP-N1). Read More

    [Role of CCL5/CCR5 in the perineural invasion of salivary adenoid cystic carcinoma cells].
    Hua Xi Kou Qiang Yi Xue Za Zhi 2017 Oct;35(5):479-483
    Dept. of Oral and Maxillofacial Surgery, Stomatological Hospital of Shandong University, Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China.
    Objective: This study aimed the role of the CCL5/CCR5 axis in the perineural invasion of salivary adenoid cystic carcinoma (SACC) cells.

    Methods: Immunohistochemical analysis and flow cytometric analysis were conducted to detect the expression of the chemokine receptor CCR5 in SACC cells. Enzyme linked immunosorbent assay (ELISA) was performed to determine the expression of CCL5 in the supernate of human nerve cells. Read More

    A Rare Case of Unresectable Adenoid Cystic Carcinoma of the Nasopharynx Treated with Intensity Modulated Proton Therapy.
    Cureus 2017 Sep 15;9(9):e1688. Epub 2017 Sep 15.
    Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center.
    Adenoid cystic carcinoma (ACC) is generally treated with surgical resection followed by postoperative radiotherapy. In cases where surgical management is precluded due to the location of the tumor and/or patient factors, radiation therapy can be offered to achieve local control. Here, we present a case of unresectable Stage T4N0 ACC of the nasopharynx with skull base and intracranial extension treated with intensity modulated proton therapy (IMPT), which achieved good local control with no significant late toxicity. Read More

    [Four Cases Report on Primary Lung Adenoid Cystic Carcinoma].
    Zhongguo Fei Ai Za Zhi 2017 Nov;20(11):789-792
    Xiangya School of Medicine Central South University, Department of Thoracic Neoplasms, Hunan Cancer Hospital, 
the Affliated Cancer Hospital of Xiangya School of Medicine, Changsha 410000, China.
    Background: Lung adenoid cystic carcinoma is a kind of rare lung cancer. Diagnosis and treatment is not enough understandable for them. We collected and analyzed 4 cases of lung adenoid cystic carcinoma for broadening the sight of this disease. Read More

    A Favorable Response to Levetiracetam in a Patient with Metastatic Adenoid Cystic Carcinoma.
    Intern Med 2017 Nov 20. Epub 2017 Nov 20.
    Department of Respiratory Medicine, Kumamoto University Hospital, Japan.
    Adenoid cystic carcinoma (ACC) is a rare cancer, and there are no standard-of-care treatments for patients with metastatic ACC. We herein report a patient with lung metastasis of ACC who achieved a favorable response to levetiracetam. A 52-year-old Japanese man was admitted to our hospital because of multiple lung metastases of ACC. Read More

    Survival Outcome of Intermediate-Grade Salivary Gland Carcinoma.
    Oncology 2017 Nov 18. Epub 2017 Nov 18.
    Department of Otolaryngology, Samsung Changwon Hospital, Sungkyunkwan University School of Medicine, Changwon, Republic of Korea.
    Objective: Histological grade is the most important factor for defining treatment strategies and predicting prognosis for salivary gland carcinoma (SGC). We examined factors affecting long-term recurrence and survival among intermediate-grade SGC (IGSGC) patients to define optimal treatment modalities and outcomes.

    Methods: We reviewed the clinical and pathological data on 108 IGSGC patients who underwent definitive surgery with or without postoperative radiotherapy. Read More

    MYBL1 rearrangements and MYB amplification in breast adenoid cystic carcinomas lacking the MYB-NFIB fusion gene.
    J Pathol 2018 Feb 28;244(2):143-150. Epub 2017 Dec 28.
    Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
    Breast adenoid cystic carcinoma (AdCC), a rare type of triple-negative breast cancer, has been shown to be driven by MYB pathway activation, most often underpinned by the MYB-NFIB fusion gene. Alternative genetic mechanisms, such as MYBL1 rearrangements, have been reported in MYB-NFIB-negative salivary gland AdCCs. Here we report on the molecular characterization by massively parallel sequencing of four breast AdCCs lacking the MYB-NFIB fusion gene. Read More

    The Prognostic Significance of Notch1 and Fatty Acid Binding Protein 7 (FABP7) Expression in Resected Tracheobronchial Adenoid Cystic Carcinoma-A Multicenter Retrospective Study.
    Cancer Res Treat 2017 Nov 15. Epub 2017 Nov 15.
    Department of Pathology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
    Purpose: Adenoid cystic carcinoma (ACC) of the trachea and bronchus is a rare tumor. Although MYB-NFIB oncogene fusion and Notch1 mutation have been identified in adenoid cystic carcinoma (ACC), little is known about the expression and clinical significance of Notch1 and its target gene fatty acid binding protein 7 (FABP7) in tracheobronchial ACC.

    Materials And Methods: Primary tracheobronchial ACC that were resected between 1998 and 2014 were identified through the pathology and oncology database from five thoracic oncology centers in China. Read More

    Garcin syndrome caused by parotid gland adenoid cystic carcinoma: A case report.
    Medicine (Baltimore) 2017 Nov;96(45):e8508
    Department of Neurology, the First Affiliate Hospital of Wenzhou Medical University, Wenzhou City, Zhejiang, P.R. China.
    Rationale: Garcin syndrome is characterized by the gradual involvement, and ultimately, unilateral paralysis of at least 7 and sometimes all cranial nerves, without intracranial hypertension or any long tract signs.

    Patient Concerns: We report the case of a 59-year-old woman who presented with Garcin syndrome, which gradually progressed over a period of 2 years.

    Diagnosis: A left parotid gland biopsy revealed parotid gland adenoid cystic carcinoma (PGACC) with perineural invasion of a peripheral nerve bundle and lymph node metastasis. Read More

    MYB Translocation Status in Salivary Gland Epithelial-Myoepithelial Carcinoma: Evaluation of Classic, Variant, and Hybrid Forms.
    Am J Surg Pathol 2017 Nov 9. Epub 2017 Nov 9.
    *Department of Pathology, The Johns Hopkins University, Baltimore, MD †Department of Pathology, UT Southwestern Medical Center, Dallas, TX.
    Epithelial-myoepithelial carcinoma (EMC) is a malignant salivary gland neoplasm comprised of a biphasic arrangement of inner luminal ductal cells and outer myoepithelial cells. Adenoid cystic carcinoma (AdCC) is also a biphasic tumor comprised of ductal and myoepithelial cells, but these components tend to be arranged in a more cribriform pattern. The occurrence of "hybrid carcinomas" that show mixed patterns of EMC and AdCC raises questions about the relationship of these morphologically overlapping but clinically distinct tumors. Read More

    Practical Tips for MR Imaging of Perineural Tumor Spread.
    Magn Reson Imaging Clin N Am 2018 Feb 21;26(1):85-100. Epub 2017 Oct 21.
    Department of Radiology, University of Florida, Veterans Administration Medical Center, 1601 Southwest Archer Road, Gainesville, FL 32608, USA.
    Perineural tumor spread (PNS) substantially alters a patient's prognosis and treatment plan. Therefore, it is critical that the radiologists are familiar with the course of cranial nerves commonly affected by PNS and the neuronal connections to appropriately map the extent of PNS. Limited involvement of a nerve by PNS might be resectable, whereas advanced PNS may require radiation therapy. Read More

    A 53-Year-Old Man With a Bronchial Mass and Multiple Bone Lesions.
    Chest 2017 Nov;152(5):e115-e119
    Department of Pathology, The University of Texas-MD Anderson Cancer Center, Houston, TX.
    Case Presentation: A 53-year-old man was admitted with complaints of back pain of 3 months' duration along with numbness and weakness in his left upper and lower extremities. He denied any respiratory complaints or anorexia but did report an 11 kg weight loss over the last 3 months. He had no other significant medical history and denied any history of cigarette smoking or recreational drug use. Read More

    The surgical treatment of metastatic spine tumors within the intramedullary compartment.
    J Neurosurg Spine 2018 Jan 10;28(1):79-87. Epub 2017 Nov 10.
    Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
    OBJECTIVE Metastasis to the spinal cord is rare, and optimal management of this disease is unclear. The authors investigated this issue by analyzing the results of surgical treatment of spinal intramedullary metastasis (IM) at a major cancer center. METHODS The authors retrospectively reviewed the medical records of 13 patients who underwent surgery for IM. Read More

    Radiotherapy for Tracheal-Bronchial Cystic Adenoid Carcinomas.
    Clin Oncol (R Coll Radiol) 2018 Jan 6;30(1):39-46. Epub 2017 Nov 6.
    Department of Radiation Oncology, Gustave Roussy Cancer Campus, Institut d'Oncologie Thoracique (IOT), Université Paris-Saclay, Villejuif, France. Electronic address:
    Aims: Primary tracheal-bronchial adenoid cystic carcinoma (thoracic adenoid cystic carcinoma; TACC) is a rare and aggressive malignant tumour. Radiotherapy results have not been previously individualised in this setting.

    Patients And Methods: Records of 31 patients with TACC (74% tracheal and 26% bronchial) who received radiotherapy between February 1984 and September 2014 were retrospectively analysed. Read More

    Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma.
    J Natl Cancer Inst 2017 Oct;109(10)
    Affiliations of authors: Departments of Genetics and The Center for Genetics and Genomics (BL, XR, GL), Pathology (YM, AKEN), Head and Neck Surgery (MZ), Thoracic/Head and Neck Medical Oncology (JianjZ), and Genomic Medicine (JianjZ, JianhZ, PAF), The University of Texas MD Anderson Cancer Center, Houston, TX.
    Background: Adenoid cystic carcinoma (ACC), an uncommon and indolent salivary gland malignancy, is characterized by varied morphologic and clinical manifestations. Molecular genetic studies of ACC identified certain structural and mutational alterations that may play a driver role in tumor development. The evolution and regional consistency of these events in ACC development progression are uncertain. Read More

    Can molecular profiling enhance radiotherapy? Impact of personalized targeted gold nanoparticles on radiosensitivity and imaging of adenoid cystic carcinoma.
    Theranostics 2017 14;7(16):3962-3971. Epub 2017 Sep 14.
    Sackler Faculty of Medicine, Tel-Aviv University, Ramat Aviv, Israel.
    Personalized molecular profiling has an established role in selection of treatment for metastatic disease; however, its role in improving radiosensitivity and functional imaging has not been evaluated. In the current study, we examined molecular profiling as a tool for designing personalized targeted gold nanoparticles (GNP) to serve as dual-modal tumor radiosensitizers and functional imaging enhancers. To this end, molecular profiling of a patient's salivary gland adenoid cystic carcinoma (ACC) was performed, and anaplastic lymphoma kinase (ALK) mutation was detected. Read More

    Epiregulin Promotes Lung Metastasis of Salivary Adenoid Cystic Carcinoma.
    Theranostics 2017 23;7(15):3700-3714. Epub 2017 Aug 23.
    Department of Oral and Maxillofacial Surgery, Peking University School and Hospital of Stomatology, Beijing, PR China.
    Salivary adenoid cystic carcinoma (SACC) is a peculiar malignant tumor, characterized by its slow but inexorable growth, with a high incidence of lung metastasis and poor prognosis. Here, we show the upregulated expression of EGFR ligand epiregulin in a subset of SACC cells correlates with lung metastasis and unfavorable outcome in patients with SACC. We found that upregulation of epiregulin in SACC cells induced epithelial-mesenchymal transition by regulating GLI1/E-cadherin. Read More

    Aggressive Adenoid Cystic Carcinoma of Maxillary Sinus in a 43-Year-Old Male: Rare Case Report and Review of Literature.
    Case Rep Med 2017 28;2017:2324717. Epub 2017 Sep 28.
    Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
    Adenoid cystic carcinoma (ACC) is a rare malignant tumor, mostly involving the minor salivary glands. Herein, we present a case of ACC in a 43-year-old man with symptoms of dental abscess as the initial presentation of the tumor. In spiral computed tomography (CT) scan, soft tissue mass with the erosion of maxillary sinus wall on the right side of the alveolar ridge was evident. Read More

    Successful Treatment of Life-threatening Tracheal Stenosis Caused by Malignancy with a Self-expanding Hybrid Stent.
    Intern Med 2018 Jan 1;57(2):259-263. Epub 2017 Nov 1.
    Department of Internal Medicine, Miyazaki Prefectural Miyazaki Hospital, Japan.
    Tracheal stenosis caused by malignancy is a life-threatening complication. We performed stent therapy in two patients using the AERO™ stent, launched in late 2016 in Japan. One patient presented with stenosis of the trachea due to adenoid cystic carcinoma and the other with stenosis of the trachea due to esophageal cancer. Read More

    Involvement of non-B cell-derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma.
    Oncol Lett 2017 Oct 21;14(4):4491-4498. Epub 2017 Aug 21.
    Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing 100191, P.R. China.
    Cancer cell-derived immunoglobulin G (cancer-IgG) has been implicated in the pathogenesis and progression of various types of cancer. However, its role in salivary adenoid cystic carcinoma (SACC) remains unclear. The present study aimed to investigate the effects of cancer-IgG on metastasis and prognosis in 96 patients with SACC. Read More

    Adenoid cystic carcinoma of the breast - an aggressive presentation with pulmonary, kidney, and brain metastases: a case report.
    J Med Case Rep 2017 Oct 29;11(1):303. Epub 2017 Oct 29.
    Department of Medical Oncology, Jules Bordet Institute, Université Libre de Bruxelles, Brussels, Belgium.
    Background: Adenoid cystic carcinoma of the breast is a rare malignant neoplasm associated with an excellent prognosis and a very rare occurrence of metastases.

    Case Presentation: We report the case of an aggressive presentation in a 65-year-old woman, of Belgian origin, who was diagnosed as having adenoid cystic carcinoma of the breast and developed metastases to her lung, kidney, and brain.

    Conclusions: We describe similar cases reported in the literature and discuss the molecular characteristics and treatment paradigm of this controversially aggressive disease entity. Read More

    The Role of Molecular Testing in the Differential Diagnosis of Salivary Gland Carcinomas.
    Am J Surg Pathol 2018 Feb;42(2):e11-e27
    Coordinator of the International Head and Neck Scientific Group, Padua, Italy.
    Salivary gland neoplasms are a morphologically heterogenous group of lesions that are often diagnostically challenging. In recent years, considerable progress in salivary gland taxonomy has been reached by the discovery of tumor type-specific fusion oncogenes generated by chromosome translocations. This review describes the clinicopathologic features of a selected group of salivary gland carcinomas with a focus on their distinctive genomic characteristics. Read More

    Tumor-derived exosomes enhance invasion and metastasis of salivary adenoid cystic carcinoma cells.
    J Oral Pathol Med 2017 Oct 23. Epub 2017 Oct 23.
    Department of Oral and Maxillofacial Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China.
    Objectives: Tumor-derived exosomes (TDE) have been shown to participate in different steps of the dissemination of cancer cells. However, the role of salivary adenoid cystic carcinoma-derived (SACC-derived) exosomes had not been documented in SACC. The study aims to explore the functions of SACC-derived TDE in SACC progression and investigate potential mechanisms. Read More

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