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    233 results match your criteria Cutis Verticis Gyrata

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    A novel homozygous mutation in the SLCO2A1 gene causing pachydermoperiostosis: Efficacy of hydroxychloroquine treatment.
    Am J Med Genet A 2018 May;176(5):1253-1257
    Department of Translational Medical Sciences, Section of Pediatrics, Federico II University, Naples, Italy.
    Pachydermoperiostosis (PDP), otherwise known as primary hypertrophic osteoarthropathy, is characterized by digital clubbing, pachydermia and subperiosteal new bone formation. Joint pain, polyarthritis, cutis verticis gyrata, seborrhea, and hyperhidrosis are frequently associated to this condition. We report a 17-year-old boy presented with pain and swelling of knees and ankles, and progressive thickening of skin face with seborrhea from about 4 years. Read More

    Idiopathic Cutis Verticis Gyrata in a Female.
    Cureus 2018 Jan 23;10(1):e2105. Epub 2018 Jan 23.
    Plastic and Reconstructive Surgery Unit, Moulay Ismail Military Hospital Meknes.
    Cutis verticis gyrata (CVG) is a benign proliferation and hypertrophy involving the scalp which exhibits furrows resembling the cerebral cortex convolutions. The diagnosis of CVG is based on clinical findings. Complementary investigations are recommended to rule out local or systemic underlying disorders. Read More

    Pachydermoperiostosis in a Patient with Crohn's Disease: Treatment and Literature Review.
    Iran J Med Sci 2018 Jan;43(1):81-85
    Medical Student, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
    Pachydermoperiostosis (PDP) is a rare disorder characterized by pachydermia, digital clubbing, periostitis, and an excess of affected males. It is the primary form of hypertrophic osteoarthropathy (HOA) and there are some rare associations of PDP with other disorders. Here we describe a patient with Crohn's disease associated with PDP. Read More

    Congenital melanocytic nevus mimicking a turban tumour in an 18-year-old Filipino male.
    BMJ Case Rep 2017 Sep 23;2017. Epub 2017 Sep 23.
    Department of Surgery, Division of Plastic Surgery, University of the Philippines Manila, Philippine General Hospital, Manila, Philippines.
    Congenital melanocytic nevi (CMN) are nevi that are present at birth or arise within the first few weeks of life. They are often found on the trunk, head and neck and extremities. We report herein an unusual presentation of a CMN as a cerebriform tumour presenting as secondary cutis verticis gyrata on the scalp of an 18-year-old Filipino male. Read More

    Pachydermoperiostosis: The value of molecular diagnosis.
    Ann Dermatol Venereol 2017 Dec 12;144(12):799-803. Epub 2017 Sep 12.
    Department of Dermatology, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France; MAGEC, hôpital Saint-Louis, AP-HP, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France. Electronic address:
    Background: Pachydermoperiostosis is a rare autosomal recessive genetic disorder characterized by the association of periostosis and pachydermia. To date, two genes involved in prostaglandin metabolism, HPGD and SLCO2A1, have been identified.

    Patients And Methods: A 7-year-old girl presented digital clubbing of the hands and feet, curved nails, hyperhidrosis, and pachydermia, as well as eczema of the trunk and limbs. Read More

    Pachydermoperiostosis of the complete type: A novel missense mutation c.101T > C in the SLCO2A1 gene.
    Eur J Med Genet 2017 Aug 8;60(8):433-436. Epub 2017 Jun 8.
    Department of Endocrinology, The First Central Hospital(BDCH), Baoding 071000, China. Electronic address:
    We report on a rare case of pachydermoperiostosis (PDP) in a 25-year-old male who was admitted to our hospital because of enlargement of fingers and toes. Through examination, we found some typical features on the patient including finger clubbing, periostosis, pachydermia, and cutis verticis gyrata (CVG). But laboratory tests were almost within normal ranges, which ruled out rheumatic arthritis, osteopulmonary arthropathy, thyroid acropathy, and acromegaly. Read More

    Is cutis verticis Gyrata-Intellectual Disability syndrome an underdiagnosed condition? A case report and review of 62 cases.
    Am J Med Genet A 2017 Mar 25;173(3):638-646. Epub 2016 Dec 25.
    Pediatric Highly Intensive Care Unit, Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
    Cutis Verticis Gyrata-Intellectual Disability (CVG-ID) syndrome is a rare neurocutaneous syndrome characterized by intellectual disability and scalp folds and furrows that are typically absent at birth and are first noticed after puberty. First reported in 1893, the syndrome was mainly identified in subjects living in psychiatric institutions, where it was found to have a prevalence of up to 11.4%. Read More

    Scalp Reconstruction With Free Latissimus Dorsi Flap in a Patient With Giant Cutis Verticis Gyrata.
    J Craniofac Surg 2016 Sep;27(6):e553-4
    Plastic, Reconstructive and Aesthetic Surgery Clinic, Okmeydani Training and Research Hospital, Istanbul, Turkey.
    Introduction: Cutis verticis gyrata is a rare skin disorder characterized by formation of thick skin folds and grooves. Because of the risk of malignant transformation, these lesions must be surgically excised. In this study, the authors aimed to present a successful reconstruction of scalp with free latissimus dorsi musculocutaneous flap after total excision of giant cerebriform intradermal nevus that causes cutis verticis gyrata. Read More

    Cutis Verticis Gyrata - A Case Report.
    Acta Dermatovenerol Croat 2016 Jun;24(2):140-3
    Assist. Prof. Jasna Zeljko-Penavić, MD, PhD, Department of Dermatology and Venereology, Clinical Hospital Mostar, Mostar, Bosnia and Herzegovina;
    Cutis verticis gyrata (CVG) is a skin condition characterized by excessive growth of the skin of the scalp, resulting in furrows and folds which are similar to the gyri of the brain cortex. CVG can be classified into two forms: primary (essential and non-essential) and secondary. We report the case of a 53-year-old male patient with the primary type of CVG. Read More

    A rare association of scleromyxedema with cutis verticis gyrata.
    Indian Dermatol Online J 2016 May-Jun;7(3):186-9
    Department of Skin and STD, Al-Ameen Medical College and Hospital, Bijapur, Karnataka, India.
    Cutis verticis gyrata (CVG) is characterized by redundant skin on the scalp that exhibits deep furrows and convolutions. We report a 58-year-old male who presented with multiple raised asymptomatic skin-colored lesions over the chest and abdomen and features of CVG. Biopsy from the lesion confirmed the diagnosis of scleromyxedema. Read More

    Successful treatment of pachydermoperiostosis with etoricoxib in a patient with a homozygous splice-site mutation in the SLCO2A1 gene.
    Br J Dermatol 2016 Feb 15. Epub 2016 Feb 15.
    Department of Dermatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
    Pachydermoperiostosis (PDP), also named primary hypertrophic osteoarthropathy (PHO: MIM 167100), is a rare genetic disease characterized by 3 major symptoms: pachydermia including cutis verticis gyrata (CVG), periostosis, and digital clubbing. Additional clinical signs and symptoms include seborrheic hyperplasia, hyperhidrosis, and arthropathy. This article is protected by copyright. Read More

    [Progress in genetic research on pachydermoperiostosis].
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 2016 Feb;33(1):105-7
    State Key Laboratory of Medical Genetics, School of Life Science, Central South University, Changsha, Hunan 410013, China.
    Pachydermoperiostosis is a rare genetic disease characterized by finger clubbing, periostosis, cutis verticis gyrata and pachydermia accompanied by acroosteolysis and hyperhidrosis. Recently, two susceptibility genes, HPGD and SLCO2A1, have been identified, whose protein products are involved in the transportation of prostaglandin and metabolism underlying pachydermoperiostosis. Here the genetic basis of pachydermoperiostosis and its correlation with its clinical phenotype are reviewed, which may provide a reference for basic research and clinic diagnosis for the disease. Read More

    Cutis verticis gyrata.
    Dermatol Online J 2016 Dec 15;22(12). Epub 2016 Dec 15.
    Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.
    Cutis verticis gyrata that involves only the face isa rare presentation of this even rarer cutaneousanomaly. We present a 61-year-old man, whodeveloped primary essential progressive cutis verticisgyrata of the face. Read More

    Pathological characterization of pachydermia in pachydermoperiostosis.
    J Dermatol 2015 Jul 11;42(7):710-4. Epub 2015 May 11.
    Department of Dermatology, Toho University School of Medicine, Tokyo, Japan.
    Pachydermoperiostosis is a rare hereditary disease, which presents with the cutaneous manifestations of pachydermia and cutis verticis gyrata. Histological findings in pachydermia frequently include dermal edema, mucin deposition, elastic fiber degeneration, dermal fibrosis and adnexal hyperplasia. However, the severity of these findings varies between clinical reports, and a systematic multiple-case clinicopathological correlative analysis has not been performed to date. Read More

    [Developmental abnormalities and nevi of the scalp].
    Hautarzt 2014 Dec;65(12):1022-9
    Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum Würzburg, Josef-Schneider-Straße 2, 97080, Würzburg, Deutschland.
    Unusual congenital or early-onset skin lesions on the scalp often pose a diagnostic challenge particularly as the clinical evaluation may be hampered by dense hair growth. Thus, this paper provides a concise review on developmental abnormalities and nevi with exclusive or predominant scalp localization. Aplasia cutis congenita occurs as an isolated finding, in association with genetic syndromes, nevi and anomalies or as a consequence of intrauterine trauma and teratogens. Read More

    The action of prostaglandins on ciliary hypertrichosis: a case report of pachydermoperiostosis.
    Int J Trichology 2014 Jan;6(1):25-6
    Prof. Rubem David Azulay Institute of Dermatology, Santa Casa da Misericordia, Rio de Janeiro, RJ, Brazil.
    Pachydermoperiostosis or primary hypertropic osteoarthropathy is a rare hereditary disorder that was first described in 1868. It is characterized by digital clubbing, pachydermia (thickening of the facial skin and/or scalp), and periostosis (swelling of periarticular tissue and subperiosteal new bone formation). We report a case of a patient with the complete form of the disease, and with a unique appearance of the hair shaft and eyelashes. Read More

    [Cutis verticis gyrata as an early rare presenting sign of acromegaly].
    Harefuah 2014 May;153(5):253-4, 306
    Cutis verticis gyrata (CVG) is a descriptive term for a dermal sign in which deep furrows and convoluted ridges are seen upon the scalp. They are formed due to thickening of the skin folds of the scalp and produce an appearance that resembles the gyri of the brain. The condition is classified primary when the etiology is unknown or neurologically based. Read More

    Cutis verticis gyrata-like skin toxicity during treatment of melanoma patients with the BRAF inhibitor vemurafenib after whole-brain radiotherapy is a consequence of the development of multiple follicular cysts and milia.
    Strahlenther Onkol 2014 Oct 28;190(11):1080-1. Epub 2014 Jun 28.
    Department of Dermatology and National Center for Tumor Diseases (NCT), University Hospital Heidelberg, Im Neuenheimer Feld 460, 69120, Heidelberg, Germany,

    Primary essential cutis verticis gyrata - case report.
    An Bras Dermatol 2014 Mar-Apr;89(2):326-8
    Complexo Hospitalar Padre Bento de Guarulhos, Guarulhos, SP, Brazil.
    Cutis verticis gyrata is characterized by excessive formation of scalp skin. It may be primary (essential and nonessential) or secondary. In the primary essential form it presents only folding skin formation on the scalp, mimicking cerebral gyri, without associated comorbidities. Read More

    Cerebriform intradermal nevus presenting as cutis verticis gyrata with multiple cellular blue nevus over the body: A rare occurrence.
    Indian Dermatol Online J 2014 Jan;5(1):34-7
    Department of Dermatology, Venereology and Leprosy. Calcutta School of Teropical Medicine, Kolkata, India.
    Cutis verticis gyrata is a rare skin condition characterized by swelling of scalp resembling the surface of the brain. Various conditions, like cerebriform intradermal nevus (CIN), may give rise to this clinical entity. Moreover, its association with cellular blue nevus is extremely rare and has not been reported so far. Read More

    Touraine Solente Gole syndrome: The elephant skin disease.
    Indian J Plast Surg 2013 Sep;46(3):577-80
    Department of Plastic & Reconstructive Surgery, Calicut, Kerala, India.
    Touraine Solente Gole syndrome is a rare hereditary syndrome of primary pachydermoperiostosis, with the characteristic triad of pachydermia (or elephant like skin), periostosis and acropachia. A 27-year-old patient presented with aesthetic deformity of forehead due to deep skin folds and coarsening of facial features due to progressive thickening of skin. Associated palmoplantar hyperkeratosis with broadened of finger and toe tips and digital clubbing were noticed. Read More

    Cutis Verticis Gyrata in Men Affected by HIV-Related Lipodystrophy.
    Dermatol Res Pract 2013 12;2013:941740. Epub 2013 Sep 12.
    Department of Dermatology, UCSF School of Medicine, 1701 Divisadero Street, 3rd Floor, San Francisco, CA 94115, USA.
    We report the occurrence of cutis verticis gyrata (CVG), a disfiguring dermatological condition, in four patients with HIV-related lipodystrophy (HIVLD). These four patients had abnormal metabolic and hormonal lab values which we compare with metabolic and hormonal perturbations cited in previous HIVLD cohorts. In addition, we describe the sole use of poly-L-lactic acid as a potential treatment for decreasing the appearance of CVG-associated ridges. Read More

    Cutis verticis gyrata as a clinical manifestation of Touraine-Solente-Gole' syndrome (pachydermoperiostosis).
    BMJ Case Rep 2013 07 12;2013. Epub 2013 Jul 12.
    Department of Internal Medicine, San Juan de Dios General Hospital, Guatemala, Guatemala.
    Cutis verticis gyrata is a descriptive term for a condition of the scalp consisting of deep grooves and convolutions that resemble the surface of the brain. We present a case of a 22-year-old man who presented with pain and swelling of both knees and hands. Enlarged wrists, ankles and feet were also noted, along with facial seborrhoea, thickening of the skin and deformity of the fingers. Read More

    Cutaneous neurocristic hamartoma presenting as cutis verticis gyrata.
    Am J Dermatopathol 2014 Mar;36(3):e66-9
    Departments of *Pathology and †Surgery, Kasturba Medical College, A unit of Manipal University, Mangalore, Karnataka, India.
    Cutaneous neurocristic hamartoma is a rare developmental complex melanocytic lesion of neural crest origin in the dermis and subcutis with diverse histological differentiation including melanocytic, neurosustentacular, and mesenchymal elements. Cutis verticis gyrata is a cerebriform thickening of the scalp manifesting as folds, ridges, or creases. We report a case of cutaneous neurocristic hamartoma of the scalp in a 20-year-old woman presenting as cutis verticis gyrata. Read More

    Isolated cutis verticis gyrata of the glabella and nasal bridge: a case report and review of the literature.
    J Plast Reconstr Aesthet Surg 2013 Oct 21;66(10):1421-3. Epub 2013 Feb 21.
    Department of Plastic & Reconstructive Surgery, Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Sydney, Australia.
    Cutis verticis gyrata (CVG) is an uncommon morphological condition of the scalp characterised by ridges and furrows resembling the surface of the brain. We present a case of secondary CVG affecting both the glabella and nasal aesthetic unit. To our knowledge, isolated CVG of the glabella has never been reported nor has extension of CVG onto the nasal aesthetic unit of the face. Read More

    Identification of mutations in the prostaglandin transporter gene SLCO2A1 and its phenotype-genotype correlation in Japanese patients with pachydermoperiostosis.
    J Dermatol Sci 2012 Oct 27;68(1):36-44. Epub 2012 Jul 27.
    Center for Integrated Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.
    Background: Pachydermoperiostosis (PDP) is a rare genetic disorder characterized by 3 major symptoms: pachydermia including cutis verticis gyrata (CVG), periostosis, and finger clubbing. Recently, a homozygous mutation in the gene HPGD, which encodes 15-hydroxyprostaglandin dehydrogenase (15-PGDH), was found to be associated with PDP. However, mutations in HPGD have not been identified in Japanese PDP patients. Read More

    Cutis verticis gyrata secondary to infiltrating ductal carcinoma breast.
    J Coll Physicians Surg Pak 2012 Feb;22(2):120-2
    Department of Dermatology, Combined Military Hospital, Malir Cantt., Karachi, Pakistan.
    Cutis verticis gyrata is a long lasting and progressive condition in which there is hypertrophy and folding of the scalp skin. It typically affects the vertex and occipital region; however, it may involve the entire scalp. Classically, it has been divided into primary and secondary forms. Read More

    Rare giant secondary cutis verticis gyrata.
    J Plast Surg Hand Surg 2011 Sep;45(4-5):212-4
    Division of Plastic Surgery, Second Affiliated Hospital of Kunming Medical College, Kunming, Yunnan, China.
    We report a case of cerebriform intradermal naevus (CIN) of the scalp in a 17-year-old girl. The clinical and histopathological presentations of the case are described and the diagnostic and therapeutic aspects presented. Read More

    Treating cutis verticis gyrata using skin expansion method.
    Cell Biochem Biophys 2012 Mar;62(2):373-6
    Department of Aesthetic and Plastic Surgery, General Hospital of Jinan Military Region, Jinan 250031, China.
    The objective of this study was to evaluate the feasibility and clinical effect of repairing scalp defect after the excision of cutis verticis gyrata using expanded scalp skin flaps. For this purpose, 8 patients with cutis verticis gyrata were subjected to scalp skin expander implantation under the skin. After saline injection and scalp expansion for 2-3 months, the cutis verticis gyrata was excised and the expanded scalp flaps were applied to recover the skin defect. Read More

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