849,479 results match your criteria Cutis Marmorata Telangiectatica Congenita

A comparative study of chemical constituents and safety of Thai herbal medicated oil formula and traditional medicated oil.

J Complement Integr Med 2021 May 13. Epub 2021 May 13.

Department of Pharmacology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Objectives: Medicated oil has been traditionally used as an analgesic medicine to relieve pain by applying to the skin over painful muscles, and has been established in The National List of Essential Medicines (2556 B.E.). Read More

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Absence of Batrachochytrium salamandrivorans in a Global Hotspot for Salamander Biodiversity.

J Wildl Dis 2021 May 13. Epub 2021 May 13.

Middle Tennessee State University, Toxicology and Disease Group, Department of Biology, 1672 Greenland Drive, Murfreesboro, Tennessee 37132, USA.

Batrachochytrium salamandrivorans (Bsal) is an emerging fungal pathogen that affects salamander and newt populations in Asia and Europe. In the Western Hemisphere, Bsal represents a major threat to endemic amphibian populations, which have not evolved resistance to infection, and which could experience local extinction events such as those observed in European fire salamanders (Salamandra salamandra). We report findings of a survey focusing specifically on wild lungless salamanders in the southeastern US, the most biodiverse location for salamander species globally. Read More

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Nuchal thickness and increased risk of surgical site infection in posterior cervical operations.

Clin Neurol Neurosurg 2021 Apr 25;205:106653. Epub 2021 Apr 25.

College of Medicine, University of Florida, Gainesville, FL, USA; Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, FL, USA.

Objective: Surgical site infections (SSI) are a common post-operative complication, which increase cost, length of stay, and morbidity. Many risk factors have been, identified including body mass index (BMI). The purpose of this study was to evaluate, whether nuchal thickness rather than BMI increases risk for post-operative SSI in, posterior approach cervical spine operations. Read More

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Paradoxal dyeing affinity's inversion of the connective tissue at Goldner's Masson trichrome staining as a peculiar characteristic of compressed and exsiccated cadaveric skin.

Leg Med (Tokyo) 2021 May 7;52:101905. Epub 2021 May 7.

Università degli Studi di Milano, Facoltà di Medicina e Chirurgia, Sezione di Medicina Legale e delle Assicurazioni, Dipartimento di Scienze Biomediche per la Salute, Via Luigi Mangiagalli 37, 20133 Milano, Italy. Electronic address:

The microscopic examination of a hanging cutaneous furrow, stained with Goldner's Masson trichrome staining, highlighted an abnormal dyeing inversion affinity of the connective tissue - red instead of green - located in the region of maximal cutaneous compression and exsiccation. To identify if this different stainability could be considered as an intrinsic characteristic of all biological tissues compressed and exsiccated, we have assessed different cadaveric skin samples that underwent traumatic detrimental phenomena that can produce such effects. We collected skin fragments from 24 corpses deceased because of gunshot injuries, electrocution, hanging, and heat-induced lesions, sampling the areas directly involved, as well as skin specimens to use as a control. Read More

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A resveratrol-loaded nanostructured lipid carrier hydrogel to enhance the anti-UV irradiation and anti-oxidant efficacy.

Colloids Surf B Biointerfaces 2021 Apr 27;204:111786. Epub 2021 Apr 27.

Department of Pharmaceutics, School of Pharmacy, Fourth Military Medical University, Xi'an, 710032, China; Key Laboratory of Gastrointestinal Pharmacology of Chinese Materia Medica of the State Administration of Traditional Chinese Medicine, Fourth Military Medical University, Xi'an, 710032, China. Electronic address:

Exposure to ultraviolet (UV) irradiation leads to the generation of reactive oxygen species (ROS) and DNA damage in skin tissue, which can further result in skin cancers. Using sunscreens is one of the most popular and the most effective method to resist UV irradiation. Resveratrol (RES) shows high absorbance in UV region and significant anti-oxidant effects. Read More

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Prescription pattern of antimicrobial use in small animal veterinary practice in Cameroon.

Top Companion Anim Med 2021 May 10:100540. Epub 2021 May 10.

College of Technology, University of Bamenda, Bambili, Cameroon. Electronic address:

Retrospective data on antimicrobial use (AMU) within the period ranging from January 2012 to December 2015 was collected to assess the antimicrobial prescription patterns in pets (cats and dogs) treated by 16 veterinary private practitioners in the two main urban cities of Cameroon (Douala and Yaounde). The vet practitioners were interviewed in order to analyze prescribing behavior and factors influencing antimicrobial prescription. Out of a total of 3928 antimicrobial prescriptions, 3673(93. Read More

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High silver concentrations in biological samples following different exposures: Two case reports.

J Trace Elem Med Biol 2021 May 7;67:126775. Epub 2021 May 7.

Centre anti-poison-toxicovigilance, CHU Angers, France.

Background: Silver is used in various industrial applications, but also in confectioneries and for therapeutic use due to its antibiotic properties. Its toxicity is not well documented and most often only in the context of professional exposure.

Aim: Here we report two cases of high silver concentrations in biological samples in two women: the first patient presented grey marks around her cuticles, probably due to her consumption of silvered sweets and the second patient presented agranulocytosis and thrombocytopenia occurring within 24 h after the topical application of a cream containing sulfadiazine and silver to burns over a large surface area. Read More

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Real-life experience with ceftolozane/tazobactam in Canada; results from the CLEAR (Canadian LEadership on Antimicrobial Real-life usage) registry.

J Glob Antimicrob Resist 2021 May 10. Epub 2021 May 10.

Department of Medical Microbiology and Infectious Diseases, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Electronic address:

Objectives: Ceftolozane/tazobactam is a cephalosporin/β-lactamase inhibitor combination with activity against Gram-negative bacilli. We report the use of ceftolozane/tazobactam in Canada using a national registry.

Methods: The CLEAR registry uses REDCap (Research Electronic Data Capture) (online survey, https://is. Read More

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Sporotrichoid distributed tuberculous panniculitis as a late complication of intravesical Bacillus Calmette-Guérin (BCG) immunotherapy.

Int J Infect Dis 2021 May 10. Epub 2021 May 10.

Department of Dermatology, Cliniques universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200, Brussels, Belgium. Electronic address:

An 82-year-old man presented with unilateral oedema of the right lower limb overlaid with multiple, sporotrichoid distributed, panniculitis lesions. These symptoms appeared in a context of immunodepression and were associated with significant weight loss and deteriorated general condition. Patient's medical history, the histological findings, PCR testing and bacterial culture led to a diagnosis of cutaneous tuberculosis due to Mycobacterium bovis. Read More

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Reducing Wasted Time Prior To Starting Thoracic Surgical Operations.

Semin Thorac Cardiovasc Surg 2021 May 10. Epub 2021 May 10.

Division of Thoracic Surgery and Interventional Pulmonology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. Electronic address:

To design and implement multidisciplinary interventions to decrease the interval between when a patient entered the operating room and when skin incision was made during thoracic surgical operations. Thirty-eight steps that occurred during the pre-incision time were identified during meetings with surgery, anesthesia, and nursing teams. Using a critical path method and Pareto analysis, standardization of intubation and positioning techniques as well as establishing strict guidelines to avoid unnecessary urinary catheter and arterial line placement were identified as high-value interventions. Read More

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High-throughput fabrication of silk fibroin/hydroxypropyl methylcellulose (SF/HPMC) manofibrous scaffolds for skin tissue engineering.

Int J Biol Macromol 2021 May 10. Epub 2021 May 10.

National Engineering Laboratory for Modern Silk, College of Textile and Engineering, Soochow University, 199 Ren-ai Road, Suzhou 215123, China.

Silk fibroin (SF) is a natural macromolecule material with good biocompatibility, which can be used to prepare a variety of biological materials. In this study, hydroxypropyl methylcellulose (HPMC) was applied to improve the properties of SF nanofibrous scaffolds (NFS) for skin tissue engineering applications. SF/HPMC NFS with varying weight ratios of SF: HPMC were prepared in batches by a modified free surface electrospinning. Read More

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Fabrication of dual layered biocompatible herbal biopatch from biological waste for skin - Tissue regenerative applications.

Int J Biol Macromol 2021 May 10. Epub 2021 May 10.

Department of Biomedical Engineering, K.P.R. Institute of Engineering and Technology, Coimbatore 641048, India.

A dual layered herbal biopolymeric patch (biopatch) with enhanced wound healing efficiency and skin mimicking functions was fabricated for skin-tissue regenerative applications. In this study, hoof keratin (KE) extracted from biological waste and gelatin (GE) was employed for KE-GE biosheet fabrication using a simple casting method. Further, the top layer of the fabricated KE-GE biosheet was coated with bioactive Matricaria recutita (Chamomile flower) extract (CH) with gelatin through an electrospraying method. Read More

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Phytochemical composition, antisnake venom and antibacterial activities of ethanolic extract of Aegiphila integrifolia (Jacq) Moldenke leaves.

Toxicon 2021 May 10. Epub 2021 May 10.

Chemical Engineering Section, Military Institute of Engineering, Rio de Janeiro, RJ, Brazil. Electronic address:

Snakebites are considered a major neglected tropical disease, resulting in around 100,000 deaths per year. The recommended treatment by the WHO is serotherapy, which has limited effectiveness against the toxins involved in local tissue damage. In some countries, patients use plants from folk medicines as antivenoms. Read More

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The polyamine regulator AMD1 up-regulates spermine levels to drive epidermal differentiation.

J Invest Dermatol 2021 May 10. Epub 2021 May 10.

Maintaining tissue homeostasis depends on a balance of cell proliferation, differentiation and apoptosis. Within the epidermis the levels of the polyamines putrescine, spermidine and spermine are altered in many different skin conditions yet their role in epidermal tissue homeostasis is poorly understood. We identify the polyamine regulator, AMD1, as a crucial regulator of keratinocyte differentiation. Read More

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Microneedles for gene and drug delivery in skin cancer therapy.

J Control Release 2021 May 10. Epub 2021 May 10.

School of Pharmacy, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7BL, UK. Electronic address:

The success of skin cancer treatment is severely limited in the route of administration because most genes and drugs cannot break through the excellent stratum corneum (SC) barrier of the skin, leading to their inability to reach the tumor tissues at therapeutic doses. As an excellent minimally invasive delivery method, microneedles (MNs) can bypass the SC and enter the skin microcirculation to achieve drug and gene delivery when used to puncture the skin. Compared with traditional administration approaches, MN-assisted gene and drug delivery have obvious advantages, in that they are simple, safe, painless, easily transport genes (such as DNA and siRNA (small interfering RNA)) and macromolecule drugs (including proteins and antibodies), and have good reproducibility. Read More

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Interferon-Gamma Release Assays Differentiate Between Mycobacterium avium Complex and Tuberculous Lymphadenitis in Children.

J Pediatr 2021 May 10. Epub 2021 May 10.

Infectious Diseases and Systemic Inflammatory Response in Pediatrics, Infectious Diseases Unit, Department of Pediatrics, Sant Joan de Déu Hospital Research Foundation, Barcelona, Spain; Center for Biomedical Network Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain; Department of Pediatrics, University of Barcelona, Barcelona, Spain; Translational Research Network in Pediatric Infectious Diseases (RITIP), Madrid, Spain. Electronic address:

Objectives: To assess the performance of interferon-gamma release assays (IGRAs) in the differential diagnosis between Mycobacterium avium complex (MAC) and tuberculosis (TB) in children affected with subacute/chronic submandibular/cervical lymphadenitis.

Study Design: Multicenter observational study comparing children with microbiologically-confirmed MAC lymphadenitis from the European NontuberculouS MycoBacterial Lymphadenitis in childrEn (ENSeMBLE) study with children with TB lymphadenitis from the Spanish Network for the Study of Pediatric TB (pTBred) database.

Results: Overall, 78 patients with MAC and 34 with TB lymphadenitis were included. Read More

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Valentin Barrecheguren (1853-1893) - Painter of the Granada Illustrations in Olavide's Atlas of Clinical Images of the Skin and Skin Diseases.

S Serrano Ortega

Actas Dermosifiliogr 2021 May 10. Epub 2021 May 10.

Catedrático de Dermatología. Profesor Emérito de la Universidad de Granada, Salvio Serrano, Spain. Electronic address:

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Safety in Dermatologic Procedures: Vascular Occlusion by Filling Materials.

Actas Dermosifiliogr 2021 May 10. Epub 2021 May 10.

Servicio de Radiología Intervencionista. Avda. de Córdoba s/n, 28041, Madrid, España.

Ischemic events are the most serious complications of facial antiaging treatment with dermal fillers. Ischemia can cause Nicolau syndrome, blindness, or even stroke. This article discusses how to prevent ischemic complications and what steps to take should a dermatologic emergency develop. Read More

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Hair of the mouse: A skin bacteria "cocktail" gets follicles back on their feet.

Cell Host Microbe 2021 May;29(5):742-744

Department of Dermatology, University of California, San Francisco, CA 94143, USA. Electronic address:

Microbes can boost cutaneous immune defense and skin reparative capacity. However, mechanistic understanding, especially of the latter, remains sparse. In this issue of Cell Host & Microbe, Wang et al. Read More

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Repeated evolution of underwater rebreathing in diving Anolis lizards.

Curr Biol 2021 May 8. Epub 2021 May 8.

Department of Ecology and Evolutionary Biology, University of Toronto, ON M5S 3B2, Canada. Electronic address:

Air-based respiration limits the use of aquatic environments by ancestrally terrestrial animals. To overcome this challenge, diving arthropods have evolved to respire without resurfacing using air held between their cuticle and surrounding water. Inspired by natural history observations in Haiti (unpublished data) and Costa Rica, we conducted experiments documenting routine air-based underwater respiration in several distantly related semi-aquatic Anolis lizard species. Read More

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A daily regimen of a ceramide-dominant moisturizing cream and cleanser restores the skin permeability barrier in adults with moderate eczema: a randomized trial.

Dermatol Ther 2021 May 13:e14970. Epub 2021 May 13.

St George Dermatology and Skin Cancer Centre, New South Wales, Australia.

The dysfunctional skin barrier in eczema patients may be attributed to decreased levels of ceramides in the stratum corneum. The aim of this study was to determine whether a two-part system consisting of a ceramide-dominant physiological lipid-based moisturizing cream and cleanser could ameliorate the signs and symptoms of moderate eczema in adults over 28 days compared to placebo. Assessments were conducted at baseline and every 7 days thereafter. Read More

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Phenome-wide association of 1809 phenotypes and COVID-19 disease progression in the Veterans Health Administration Million Veteran Program.

PLoS One 2021 13;16(5):e0251651. Epub 2021 May 13.

Massachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, Massachusetts, United States of America.

Background: The risk factors associated with the stages of Coronavirus Disease-2019 (COVID-19) disease progression are not well known. We aim to identify risk factors specific to each state of COVID-19 progression from SARS-CoV-2 infection through death.

Methods And Results: We included 648,202 participants from the Veteran Affairs Million Veteran Program (2011-). Read More

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Latent leprosy infection identified by dual RLEP and anti-PGL-I positivity: Implications for new control strategies.

PLoS One 2021 13;16(5):e0251631. Epub 2021 May 13.

Colorado State University, Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Fort Collins, CO, Unites States of America.

The number of new cases of leprosy reported worldwide has remained essentially unchanged for the last decade despite continued global use of free multidrug therapy (MDT) provided to any diagnosed leprosy patient. In order to more effectively interrupt the chain of transmission, new strategies will be required to detect those with latent disease who contribute to furthering transmission. To improve the ability to diagnose leprosy earlier in asymptomatic infected individuals, we examined the combined use of two well-known biomarkers of M. Read More

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Strawberry fruit skins are far more permeable to osmotic water uptake than to transpirational water loss.

PLoS One 2021 13;16(5):e0251351. Epub 2021 May 13.

Institute for Horticultural Production Systems, Leibniz-Universität Hannover, Hannover, Germany.

Water movements through the fruit skin play critical roles in many disorders of strawberry (Fragaria × ananassa Duch.) such as water soaking, cracking and shriveling. The objective was to identify the mechanisms of fruit water loss (dry skin, transpiration) and water uptake (wet skin, osmosis). Read More

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The use of 33 MHz ultra-high-frequency ultrasonography for the evaluation of sweat glands in the axilla with osmidrosis.

PLoS One 2021 13;16(5):e0251600. Epub 2021 May 13.

ViewClinic Momonosato, Tamano, Japan.

Background: This study aimed to assess the use of 33 MHz ultra-high-frequency ultrasonography (33MHz-UHFUS) for evaluating axillary sweat glands with osmidrosis in comparison with histological techniques. Axillary osmidrosis is a common problem in Asian societies, and the number and size of apocrine sweat glands have a strong relationship with osmidrosis severity. Currently, there are no methods to evaluate sweat gland distribution non-invasively. Read More

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Melanocytes determine angiogenesis gene expression across human tissues.

PLoS One 2021 13;16(5):e0251121. Epub 2021 May 13.

Department of Surgery, Harvard Medical School, The Center for Engineering in Medicine, Massachusetts General Hospital, Boston, Massachusetts, United States of America.

Several angiogenesis-dependent diseases, including age-related macular degeneration and infantile hemangioma, display differential prevalence among Black, as compared to White individuals. Although socioeconomic status and genetic architecture have been suggested as explaining these differences, we have recently shown that pigment production per se might be involved. For example, we have shown that the extracellular protein fibromodulin is a pro-angiogenic factor highly secreted by melanocytes in White but not Black individuals. Read More

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A novel (targeted) kinesio taping application on chronic low back pain: Randomized clinical trial.

PLoS One 2021 13;16(5):e0250686. Epub 2021 May 13.

Department of Orthopaedic Surgery, Hospital Arnau de Vilanova, Valencia, Spain.

The aim of the present clinical trial is to evaluate the efficacy of kinesio taping on patients with chronic low back pain, when the exploration identifies skin/fascia mobilization as a factor that could modify the treatment effect. This study is a randomized controlled trial with intention-to-treat analysis. Sixty-two participants with chronic low back pain were therefore recruited from a tertiary referral hospital. Read More

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The impact of genetic background and sex on the phenotype of IL-23 induced murine spondyloarthritis.

PLoS One 2021 13;16(5):e0247149. Epub 2021 May 13.

Brigham and Women's Hospital, Boston, MA, United States of America.

Background: Overexpression of IL-23 in adult mice by means of hydrodynamic tail vein injection of IL-23 minicircles has been reported to result in spondyloarthritis-like disease. The impact of genetic background and sex on the disease phenotype in this model has not been investigated.

Methods: We compared male B10. Read More

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Liver Damage and Exposure to Toxic Concentrations of Endogenous Retinoids in the Pathogenesis of COVID-19 Disease: Hypothesis.

Viral Immunol 2021 May 13. Epub 2021 May 13.

Department of Ophthalmology and Pathology, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a marked tropism for the biliary tract; it damages the bile ducts and hepatocytes and can lead to liver decompensation, cirrhosis, and sepsis. The pathogenesis of liver damage and its association with damage to the lung, heart, and brain and to the other protean manifestations of COVID-19 disease are not fully understood. In particular, tissue damage from thinning and leaky blood vessels appears to result from an inflammatory response to the virus rather than the virus itself. Read More

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Ionic Liquid-Enabled Topical Delivery of Immunomodulators.

ACS Biomater Sci Eng 2021 May 13. Epub 2021 May 13.

John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, United States.

Skin is one of the most immunologically active organs of the body due to the presence of diverse immune cells and its active involvement in the innate and adaptive immunity. Because of its unique location and immunological role, skin offers an excellent site for the introduction of immunomodulators to synergize with the active immune microenviroment for the desired outcome. However, delivery of immunomodulators to the skin remains a significant challenge due to the skin's barrier properties. Read More

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