792 results match your criteria Cutaneous and Ocular Toxicology [Journal]


Carvone protects against paclitaxel-induced retinal and optic nerve cytotoxicity: a histopathological study.

Cutan Ocul Toxicol 2019 Apr 23:1-10. Epub 2019 Apr 23.

f Department of Pathology , Regional Training and Research Hospital , Erzurum , Turkey.

Purpose: Carvone (CVN) is a natural monoterpene found in essential oils of many aromatic plant species. In the present study, we investigated the protective effect of CVN against paclitaxel (PTX)-induced retinal and optic nerve cytotoxicity in rats.

Methods: 24 male adult Wistar albino rats (250-400g) were randomized into 4 equal groups comprising 6 animals in each. Read More

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http://dx.doi.org/10.1080/15569527.2019.1608229DOI Listing

Corneal Thickness and Endothelial Changes in Long-Term Hydroxychloroquine Use.

Cutan Ocul Toxicol 2019 Apr 23:1-13. Epub 2019 Apr 23.

c Dept. of Rheumatology , Kırıkkale University Medical Faculty , Kırıkkale , Turkey.

Objective: To determine possible associations between long-term HCQ use and corneal changes in patients who used HCQ for at least three years.

Materials And Methods: The study included 62 healthy controls and 62 consecutive patients who used HCQ for the treatment of rheumatologic disease and were referred to the ophthalmology department between August 2018 and November 2018 for HCQ retinal toxicity screening. Central corneal thickness (CCT), corneal endothelial cell density (ECD), the coefficient of variation (CV) of cell size, and the percentage of hexagonal cells (HEX) were measured to evaluate changes in the cornea. Read More

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http://dx.doi.org/10.1080/15569527.2019.1608228DOI Listing

The effect of hyperbaric oxygen therapy on retinal thickness and progression of retinopathy in patients with type 2 diabetes: a prospective cohort study.

Cutan Ocul Toxicol 2019 Apr 22:1-22. Epub 2019 Apr 22.

a Department of Ophthalmology , Bagcilar Training and Research Hospital , Istanbul , Turkey.

Purpose: Evaluation of the effect of hyperbaric oxygen therapy (HBOT) on the progression of retinopathy, choroidal and retinal thickness in patients with type 2 diabetes mellitus (DM).

Materials And Methods: This prospective non-randomized cohort study consisted of 60 eyes of 30 patients who received 30 sessions of HBOT for a diabetic foot ulcer. The participants were divided into 3 groups; group 1: mild-moderate non-proliferative diabetic retinopathy (DRP) (n = 14), group 2: severe non-proliferative DRP (n = 20) and group 3: DRP without active proliferative findings with the applied laser for at least 2 years (n = 26). Read More

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http://dx.doi.org/10.1080/15569527.2019.1608226DOI Listing

Effect of intravitreal aflibercept treatment on retinal vessel parameters in diabetic macular edema: Arteriolar vasoconstriction.

Cutan Ocul Toxicol 2019 Apr 22:1-24. Epub 2019 Apr 22.

a Department of Ophthalmology, Faculty of Medicine , Afyonkarahisar Health Sciences University , Afyonkarahisar / TURKEY.

Purpose: To evaluate the effects of intravitreal aflibercept (IVA) treatment on retinal vein parameters and choroidal thickness used in the treatment of diabetic macular edema (DME).

Methods: This retrospective study administered Afyonkarahisar Health Sciences University Department of Ophthalmology. Twenty-nine patients who were diagnosed with naive DME in a single eye. Read More

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http://dx.doi.org/10.1080/15569527.2019.1594875DOI Listing

Targeted Tumour Therapy Induced Papulopustular Rash and Other Dermatologic Side Effects: A Retrospective Study.

Cutan Ocul Toxicol 2019 Apr 22:1-27. Epub 2019 Apr 22.

b Department of Dermatology and Venereology , Abdurrahman Yurtaslan Oncology Training and Research Hospital , Ankara , Turkey.

Background: Papulopustular rash is the most common cutaneous adverse effect during targeted tumour therapy particularly with epidermal growth factor receptor inhibitors (EGFRIs).

Objective: To evaluate the adverse skin reactions, mainly papulopustular rash, caused by targeted tumour therapy.

Materials And Methods: We retrospectively analyzed the data of patients who were diagnosed papulopustular rash due to targeted chemotherapeutic agents between January-2016 and August-2018. Read More

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http://dx.doi.org/10.1080/15569527.2019.1594874DOI Listing

Three-tier testing approach for optimal ocular tolerance sunscreen.

Cutan Ocul Toxicol 2019 Apr 1:1-26. Epub 2019 Apr 1.

a Innovation and Development ISDIN SA , Provençals 33 , Barcelona , Spain.

Background: Poor ocular tolerance of sunscreens is partially responsible for poor compliance in use of sunscreens. A three-tiered approach for the testing of ocular tolerance for such products is described that includes an in vitro test for ocular irritation, an in vitro test for activation of pain receptors, and finally a clinical study involving ocular instillation of the product under controlled conditions followed by ophthalmologic and subjective self-evaluation on a graded scale. We report the results for a new water-based facial sunscreen (SCFW) with very good ocular tolerance. Read More

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http://dx.doi.org/10.1080/15569527.2019.1601106DOI Listing

Accelerated wound healing with a dexpanthenol-containing ointment after fractional ablative CO laser resurfacing of photo-damaged skin in a randomized prospective clinical trial.

Cutan Ocul Toxicol 2019 Mar 21:1-5. Epub 2019 Mar 21.

a Department of Dermatology and Allergology, Medical Faculty , RWTH Aachen University , Aachen , Germany.

Background: Laser therapy with an ablative CO laser is a prominent treatment option for photo-damaged skin. The healing process and therefore the success of a laser can be supported by an appropriate postoperative treatment of the laser-treated skin.

Objective: The effect of a dexpanthenol-containing ointment with petroleum jelly on wound healing after fractional ablative CO laser therapy of photo-damaged skin. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2019.1
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http://dx.doi.org/10.1080/15569527.2019.1597879DOI Listing
March 2019
5 Reads

Effect of taxifolin on development of retinopathy in alloxan-induced diabetic rats.

Cutan Ocul Toxicol 2019 Mar 22:1-6. Epub 2019 Mar 22.

b Department of Pharmacology, Faculty of Medicine , Erzincan Binali Yildirim University , Erzincan , Turkey.

Purpose: Diabetic retinopathy (DR) is one of the leading causes of blindness. In DR patients, antioxidant defence is disrupted, and production of reactive oxygen species and pro-inflammatory cytokines such as interleukin 1β (IL-1β) and tumour necrosis factor alpha (TNF-α) increases. Taxifolin has been reported to suppress reactive oxygen species, IL-1β and TNF-α production. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2019.1
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http://dx.doi.org/10.1080/15569527.2019.1588289DOI Listing
March 2019
8 Reads

Contact sensitivity to textile dyes in patients with pigmented purpuric dermatosis.

Cutan Ocul Toxicol 2019 Mar 7:1-3. Epub 2019 Mar 7.

a Department of Dermatology , Kocaeli University School of Medicine , Kocaeli , Turkey.

Purpose: The aetiology of pigmented purpuric dermatoses is unclear. Recent studies speculate about contact sensitivity to play a role in the aetiology of the disease. In most patients, the lesions begin and stay limited on the lower extremities as textile products are in tight contact with the skin. Read More

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http://dx.doi.org/10.1080/15569527.2019.1590391DOI Listing
March 2019
1 Read

The effect of topical latanoprost on corneal clarity; 1-year prospective study.

Cutan Ocul Toxicol 2019 Mar 7:1-5. Epub 2019 Mar 7.

a Ulucanlar Eye Research Hospital , Ankara , Turkey.

Purpose: Quantitatively investigate the effects of topical latanoprost on the corneal optical density parameters by using Scheimpflug system.

Materials And Methods: New cases of primary open-angle glaucoma treated with topical latanoprost as first-line treatment were enrolled in this prospective study. Corneal densitometry measurements obtained with the Scheimpflug system (Pentacam; Oculus, HR) at baseline and 1st, 3rd, 12th months after topical latanoprost treatment. Read More

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http://dx.doi.org/10.1080/15569527.2019.1590390DOI Listing
March 2019
6 Reads

Spirulina, Palmaria palmata, Cichorium intybus, and Medicago sativa extracts in cosmetic formulations: an integrated approach of in vitro toxicity and in vivo acceptability studies.

Cutan Ocul Toxicol 2019 Mar 1:1-25. Epub 2019 Mar 1.

a School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo , Ribeirão Preto , SP , Brazil.

Background/aims: The selection of suitable raw materials in the cosmetic research and development is a key point, not only in order to obtain the expected results but also to avoid undesirable side effects. This study evaluated the in vitro toxicity potential of four different plant extracts and their in vivo acceptability studies.

Methods: Spirulina, Palmaria palmata, Cichorium intybus, and Medicago sativa extracts were analysed alone or in combination and added in cosmetic formulations. Read More

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http://dx.doi.org/10.1080/15569527.2019.1579224DOI Listing
March 2019
5 Reads

Acute effect of caffeine on pattern-reversal visual evoked potential: a randomized-controlled study.

Cutan Ocul Toxicol 2019 Feb 22:1-4. Epub 2019 Feb 22.

c Department of Neurology, Medical Faculty, Ege University , Izmir , Turkey.

Purpose: This study was aimed to investigate the acute effect of caffeine intake on pattern-reversal (PR) visual evoked potential (VEP).

Methods: This randomized controlled study included 40 participants who were divided into two groups randomly (group 1 [study group, n = 20] and group 2 [control group, n = 20]). While the study group received coffee beverages made from 6 g pure coffee beans (36 mg of caffeine per gram) containing approximately 216 mg caffeine, the control group was given beverages containing 200 mg lactose without caffeine. Read More

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http://dx.doi.org/10.1080/15569527.2019.1583248DOI Listing
February 2019
1 Read

The impact of intravitreal dexamethasone implant (Ozurdex®) on retrobulbar hemodynamics in patients with diabetic macular edema and retinal vein occlusions.

Cutan Ocul Toxicol 2019 Feb 17:1-9. Epub 2019 Feb 17.

a Department of Ophthalmology , Ministry of Health - Ordu University Research and Training Hospital , Ordu , Turkey.

Objective: To evaluate the effect of single intravitreal dexamethasone implant (Ozurdex) on ocular blood flow velocities in patients with diabetic macular oedema (DME) and retinal vein occlusions (RVO).

Methods: This prospective non-randomized interventional study included injected and fellow eyes of 12 patients with DME and of 16 patients with RVO treated with intravitreal Ozurdex. Colour Doppler Ultrasonography (CDU) measures of the central retinal artery (CRA), posterior ciliary artery (PCA), ophthalmic artery (OA) those are peak systolic velocity (PSV), end diastolic velocity (EDV), resistive index (RI) and pulsatility index (PI) were performed in both injected and uninjected eyes before injection, at one week, one month after injection, and prior to re-injection. Read More

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http://dx.doi.org/10.1080/15569527.2019.1582061DOI Listing
February 2019
1 Read

Topical application of povidone-iodine/dimethylsulfoxide ophthalmic gel preparation in Dutch-Belted rabbits.

Cutan Ocul Toxicol 2019 Feb 10:1-6. Epub 2019 Feb 10.

a Veloce BioPharma LLC , Fort Lauderdale , FL , USA.

Purpose: To determine the ocular and systemic toxicity of a novel, topically applied ophthalmic gel preparation of povidone-iodine (PVP-I) and dimethylsulfoxide (DMSO) in Dutch-Belted rabbits.

Materials And Methods: Rabbits were administered doses of the test material or control by ocular instillation four times/eye/day, 7 d/week, for a minimum of 14 consecutive days. Dosing consisted of instillation of 50 µl of the appropriate test material solution or control material (saline) into each eye of the rabbit. Read More

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http://dx.doi.org/10.1080/15569527.2019.1579225DOI Listing
February 2019
3 Reads

Therapeutic Effects of Three Human-derived Materials in a Mouse Corneal Alkali Burn Model.

Cutan Ocul Toxicol 2019 Feb 10:1-24. Epub 2019 Feb 10.

e Department of Ophthalmology , Ewha Womans University Mok-dong Hospital , Mok-dong, Yangcheon-gu , Seoul , Korea, Republic of.

Purpose: To compare the therapeutic effects of human derivatives in a mouse alkali burn model.

Methods: The right eyes of mice were injured using NaOH. After alkali injury, one of the following agents was topically administered for 7 days: human amniotic membrane (hAM) suspension, human umbilical cord serum (hUCS), and human peripheral blood serum (hPBS), or saline. Read More

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http://dx.doi.org/10.1080/15569527.2019.1573244DOI Listing
February 2019
1 Read

The effect of voluntary fasting and dehydration on posterior ocular structures.

Authors:
Zeynep Duru

Cutan Ocul Toxicol 2019 Jun 1;38(2):190-195. Epub 2019 Mar 1.

a Department of Ophthalmology , Kayseri Education and Research Hospital , Kayseri , Turkey.

Purpose: Islamic Ramadan is the month of fasting, in which intake of food and drink is restricted from sunrise until sunset. The objective of the present study was to find out the effects of religious fasting on posterior ocular structures.

Materials And Methods: In this prospective study, 34 eyes of 34 healthy volunteers with a mean age of 34. Read More

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http://dx.doi.org/10.1080/15569527.2019.1573245DOI Listing
June 2019
2 Reads

Direct and crossover effects of brinzolamide, betaxolol, and latanoprost on choroidal thickness.

Cutan Ocul Toxicol 2019 Jun 1;38(2):196-200. Epub 2019 Mar 1.

a Department of Opthalmology , Recep Tayyip Erdoğan Üniversitesi Zihni Derin Yerleşkesi , Rize , Turkey.

Purpose: To investigate the acute effects of brinzolamide, betaxolol, and latanoprost (drugs commonly used in the medical management of glaucoma) on choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: Ninety healthy volunteers were evaluated in this prospective study. Participants were randomly divided into 3 groups. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2019.1
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http://dx.doi.org/10.1080/15569527.2019.1575390DOI Listing
June 2019
3 Reads

The safety of intraocular usage of aspirin.

Cutan Ocul Toxicol 2019 Jun 1;38(2):201-205. Epub 2019 Mar 1.

a Department of Ophthalmology, Cerrahpaşa Medical Faculty , Istanbul University - Cerrahpaşa , Istanbul , Turkey.

Purpose: To determine the effects of intravitreally injected aspirin on normal ocular tissues.

Methods: Six eyes of 3 rabbits as a control group, 18 eyes of 9 albino rabbits which were injected aspirin intravitreally were studied. In the control group, the same volume of balanced salt solution (BSS) as in drug groups were injected. Read More

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http://dx.doi.org/10.1080/15569527.2019.1575391DOI Listing
June 2019
5 Reads

Antioxidant effects of piperine in in-vivo chick embryo cataract model induced by steroids.

Cutan Ocul Toxicol 2019 Jun 1;38(2):182-189. Epub 2019 Mar 1.

c The Department of the Anatomy , Afyonkarahisar Health Sciences University , Afyonkarahisar , Turkey.

Purpose: The etiopathogenesis of steroid-induced cataracts is unknown. One hypothesis is that the higher reactive oxygen species (ROS) levels play an important role in the pathogenesis of several disorders, including the evolution of cataracts. This study investigated the antioxidant effects of piperine in our steroid-induced chick embryo lens model. Read More

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http://dx.doi.org/10.1080/15569527.2019.1570521DOI Listing
June 2019
2 Reads

Phytodermatitis in East and southeast of Turkey: A prospective study.

Authors:
Isa An Murat Ozturk

Cutan Ocul Toxicol 2019 Jun 17;38(2):176-181. Epub 2019 Feb 17.

b Department of Dermatology , Health Sciences Universty Van Training and Research Hospital , Van , Turkey.

Objective: Some plants may cause cutaneous side effects called phytodermatitis due to skin contact. Plants that cause phytodermatitis vary according to countries and regions. The aim of this study was to examine the phytodermatitis cases seen in Turkey's east and southeast and compare them with phytodermatitis cases seen previously in the literature in these provinces and to revise the literature. Read More

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http://dx.doi.org/10.1080/15569527.2018.1561711DOI Listing
June 2019
6 Reads

Evaluation of formaldehyde as an ocular irritant: a systematic review and Meta-analysis.

Cutan Ocul Toxicol 2019 Jun 17;38(2):169-175. Epub 2019 Feb 17.

d Grade of Nurse , Hospital Dr Peset , Valencia , Spain.

Objective: The aim of this study was to use meta-regression to evaluate the safety of the maximum allowable dose of formaldehyde in terms of eye irritation symptoms.

Methods: We performed a systematic review of literature published in the PubMed, Embase, Lilacs, Web of Science, and Cochrane Library databases. We selected clinical trials, cohort studies, and case-control studies that compared eye irritation between patients exposed and not exposed to formaldehyde. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1561709DOI Listing
June 2019
17 Reads

Audit of toxic effects of body paint in the tiger dancers (Hulivesha) of Mangalore, India: an investigational study.

Cutan Ocul Toxicol 2019 Jun 24;38(2):118-124. Epub 2019 Jan 24.

c Father Muller Research Centre, Father Muller Charitable Institutions , Mangalore , India.

Introduction: Tiger dancing or Hulivesha, where the volunteers paint their bare body like a tiger and dance in a ritual during the Navarathri festival in Mangalore, India. There are no scientific studies done with the Hulivesha dancers at all, and therefore, we investigated the adverse effects of painting body like a tiger and dancing in the volunteers.

Objective/aim: In this study, we investigated the clinico-haematological effects of topical application of lead-containing paint and dancing for three consecutive days in these dancers to ascertain the toxic effects of whole body painting and dancing. Read More

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http://dx.doi.org/10.1080/15569527.2018.1529036DOI Listing
June 2019
5 Reads

The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis.

Cutan Ocul Toxicol 2019 Jun 28;38(2):105-111. Epub 2019 Jan 28.

a Department of Pharmacy , Renmin Hospital of Wuhan University , Wuhan , Hubei , P.R. China.

Background: This meta-analysis was conducted to assess the risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients.

Methods: We considered relevant prospective randomized phase I, II, and III trials of melanoma patients on the combined BRAF and MEK inhibition versus BRAF inhibition, describing events of rash, photosensitivity reaction (PR), hyperkeratosis (HK), alopecia, cutaneous squamous-cell carcinom(cSCC), skin papilloma(SP), pruritus, and hand-foot syndrome(HFS), as eligible for inclusion.

Results: Eight trials comprising 3163 patients were included in the meta-analysis. Read More

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http://dx.doi.org/10.1080/15569527.2018.1553180DOI Listing
June 2019
2 Reads

(3R, 3'R)-zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markers.

Cutan Ocul Toxicol 2019 Jun 28;38(2):161-168. Epub 2019 Jan 28.

g Research and Development, OmniActive Health Technologies Inc , Morristown , NJ , USA.

Purpose: Zeaxanthin protects the macula from ocular damage due to light or radiation by scavenging harmful reactive oxygen species. In the present study, zeaxanthin product (OmniXan®; OMX), derived from paprika pods (Capsicum annum; Family-Solanaceae), was tested for its efficacy in the rat retina against photooxidation.

Methods: Forty-two male 8-week-old Wistar rats exposed to 12L/12D, 16L/8D and 24L/0D hours of intense light conditions were orally administrated either 0 or 100 mg/kg BW of zeaxanthin concentration. Read More

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http://dx.doi.org/10.1080/15569527.2018.1554667DOI Listing
June 2019
5 Reads

United States regulatory requirements for skin and eye irritation testing.

Cutan Ocul Toxicol 2019 Jun 26;38(2):141-155. Epub 2018 Dec 26.

a Integrated Laboratory Systems, Inc , Morrisville , NC , USA.

Purpose: Eye and skin irritation test data are required or considered by chemical regulation authorities in the United States to develop product hazard labelling and/or to assess risks for exposure to skin- and eye-irritating chemicals. The combination of animal welfare concerns and interest in implementing methods with greater human relevance has led to the development of non-animal skin- and eye-irritation test methods. To identify opportunities for regulatory uses of non-animal replacements for skin and eye irritation tests, the needs and uses for these types of test data at U. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1540494DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453729PMC
June 2019
13 Reads

Safety of sodium hyaluronate eye drop with C12-benzalkonium chloride.

Cutan Ocul Toxicol 2019 Jun 16;38(2):156-160. Epub 2019 Jan 16.

a Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences , Nagasaki University , Nagasaki , Japan.

Purpose: In this study, we investigated the effects of commercially available multi-dose sodium hyaluronate 0.1% (Hyalein; Santen, Osaka, Japan) containing 0.003% C12-benzalkonium chloride (BAC) on the Corneal epithelium and its degree of safety. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1543316DOI Listing
June 2019
12 Reads

The effects of lutein on optic nerve injury induced by ethambutol and isoniazid: an experimental study.

Cutan Ocul Toxicol 2019 Jun 26;38(2):136-140. Epub 2018 Nov 26.

d Department of Biochemistry , Atatürk University , Erzurum , Turkey.

Aim: Ethambutol and isoniazid are two major effective first line agents in tuberculosis treatment having some visual adverse effects. We aimed to determine the protective effects of lutein on oxidative optic neuropathy induced by ethambutol and isoniazid in an experimental model.

Material And Method: Totally 24 albino Wistar male rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group), 50 mg/kg ethambutol +50 mg/kg isoniazid administered group (EI), 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1539010DOI Listing
June 2019
16 Reads
0.920 Impact Factor

Swept-source optical coherence tomography analysis in asthmatic children under inhaled corticosteroid therapy.

Cutan Ocul Toxicol 2019 Jun 23;38(2):131-135. Epub 2018 Nov 23.

d Department of Ophthalmology , Trabzon Kanuni Training and Research Hospital , Trabzon , Turkey.

Purpose: To evaluate retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), subfoveal choroidal thickness (SFCT), and central retinal thickness (CRT) in asthmatic children who were under inhaled corticosteroid treatment by using Swept-Source Optical Coherence Tomography (SS-OCT).

Material And Methods: Fifty-three children were prospectively analyzed in the study. Group 1 included 31 asthmatic children and group 2 included 22 healthy children. Read More

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http://dx.doi.org/10.1080/15569527.2018.1539009DOI Listing
June 2019
4 Reads

Evaluation of xenon, light-emitting diode (LED) and halogen light toxicity on cultured retinal pigment epithelial cells.

Cutan Ocul Toxicol 2019 Jun 23;38(2):125-130. Epub 2018 Nov 23.

d Department of Ophthalmology , Bezmialem Vakif University , Istanbul , Turkey.

Objective: To compare the possible toxic effects of three light sources used in vitreoretinal endoillumination systems; halogen, xenon, and light-emitting diode (LED) on retinal pigment epithelium (RPE) cell cultures, after two different exposure times.

Material And Methods: ARPE-19 human RPE cell cultures were exposed to halogen, xenon, and LED light sources at a distance of 1.5 cm for 30 and 60 min with equal lumen output levels. Read More

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http://dx.doi.org/10.1080/15569527.2018.1539008DOI Listing
June 2019
6 Reads

Long-term systemic administration with low dose of 3,4-methylenedioxymethamphetamine causes photoreceptor cell damage in CD1 mice.

Cutan Ocul Toxicol 2019 Mar 26;38(1):81-87. Epub 2018 Nov 26.

b Department of Ophthalmology , Shenzhen Children's Hospital , Shenzhen , People's Republic of China.

Objective: As a powerful psychostimulant with high potential for abuse, 3,4-methylenedioxymethamphetamine (MDMA) causes long-lasting neurotoxicity. This study was to investigate the effects of systemic administration of MDMA on retinal damage in CD1 mice and its underlying mechanisms.

Material And Methods: CD1 mice were randomly divided into two groups (n = 10): group 1 receiving PBS by intraperitoneal injection daily; group 2 receiving 2 mg/kg MDMA by intraperitoneal injection daily for 3 months. Read More

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http://dx.doi.org/10.1080/15569527.2018.1539007DOI Listing
March 2019
2 Reads

Extracts of different pollen species and their effect on human tear fluid and an epithelial cell line.

Cutan Ocul Toxicol 2019 Mar 13;38(1):93-103. Epub 2018 Nov 13.

a Department of Ophthalmology , Medical University of Graz , Graz , Austria.

Purpose: Hazelnut and birch pollen are known to destroy tear film components and attack ocular surface cells. We investigated further pollen species from different plant families, whether they show similar effects on human tear fluid and an epithelial cell line in vitro, to provide a broad basis for further research on pollen reactions affecting the tear film and ocular surface.

Materials And Methods: Regional pollen species from different plant families (Adoxaceae, Betulaceae, Fagaceae, Juglandaceae, Malvaceae, Oleaceae, Pinaceae, Plantaginaceae, Poaceae, Salicaceae, Sapindaceae) were collected. Read More

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http://dx.doi.org/10.1080/15569527.2018.1530259DOI Listing
March 2019
5 Reads

The effects of lycopene on alloxan induced diabetic optic neuropathy.

Cutan Ocul Toxicol 2019 Mar 23;38(1):88-92. Epub 2018 Nov 23.

d Department of Pharmacology , Erzincan University Hospital, College of Medicine , Erzincan , Turkey.

Aim: To determine the effects of lycopene treatment in prevention of diabetes associated inflammatory response and oxidative stress in an experimental model. With this aim we investigated the levels of oxidative stress markers including Malondialdehyde (MDA), and total oxidative status (TOS)together with inflammatory markers including nuclear factor- kappa B (NFKB) and tumor necrosis factor α (TNF-α) and antioxidants including total glutathione (TGSH), total oxidative status (TOS) and total anti-oxidative status (TAS) levels on eye tissue.

Material And Methods: Totally 18 albino Wistar male rats (250-280 grams) assigned into three groups, with six rats in each group as follows: healthy group (HG), control group (CG), and lycopene group (LG). Read More

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http://dx.doi.org/10.1080/15569527.2018.1530258DOI Listing
March 2019
8 Reads

Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes.

Cutan Ocul Toxicol 2019 Mar 9;38(1):66-80. Epub 2019 Jan 9.

b Department of Anatomy and Physiology , Nanotechnology Innovation Center of Kansas State (NICKS), Kansas State University , Manhattan , KS , USA.

Purpose: The aim of this study was to evaluate and compare the toxicity of six different types of titanium dioxide (TiO) nanoparticles (NP) on human epidermal keratinocytes (HEK).

Materials And Methods: Six TiO NP (A (10 nm), A*(32 nm), B (27.5 nm), C (200 nm), C*(30-40 nm), and D*(200-400 nm)) were suspended in water or culture medium and characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1527848DOI Listing
March 2019
12 Reads

The protective effects of astaxanthin against cisplatin-induced retinal toxicity.

Cutan Ocul Toxicol 2019 Mar 9;38(1):59-65. Epub 2019 Jan 9.

b Department of Histology and Embryology, Faculty of Medicine , Recep Tayyip Erdogan University , Rize , Turkey.

Purpose: This study investigated the toxic effects of an antineoplastic agent, cisplatin (CIS), on retinal cells and the potential capacity of astaxanthin (ASTA) to elicit a future therapeutic protocol in CIS-induced retinal toxicity.

Materials And Methods: Six groups were formed for the assessment; control (healthy; Group 1), olive oil (olive oil only; Group 2), ASTA control group (ASTA only, Group 3), the single intraperitoneal (IP) dose of 16 mg/kg CIS (CIS only group; Group 4), 16 mg/kg CIS +25 mg/kg (IP) ASTA (Group 5), and 16 mg/kg CIS +75 mg/kg (IP) ASTA (Group 6). On the third day after CIS administration, rats in all groups were sacrificed under anesthesia and the analysis of the biochemical parameters and histopathological levels were performed. Read More

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http://dx.doi.org/10.1080/15569527.2018.1518330DOI Listing
March 2019
2 Reads

Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: a randomized, split-face, open-label, single-center study.

Cutan Ocul Toxicol 2019 Mar 20;38(1):48-54. Epub 2018 Dec 20.

a Department of Dermatology , The Third affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Background: Topical drugs for mild to moderate acne include adapalene (ADA) and benzoyl peroxide(BPO). Supramolecular salicylic acid (SSA), a modified SA preparation, is considered as a new effective therapeutic scheme.

Objectives: To compare the safety and efficacy of 2% supramolecular SA (2% SSA) with 0. Read More

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http://dx.doi.org/10.1080/15569527.2018.1518329DOI Listing
March 2019
5 Reads

Thiol/disulfide homeostasis as a marker of oxidative stress in rosacea: a controlled spectrophotometric study.

Cutan Ocul Toxicol 2019 Mar 2;38(1):55-58. Epub 2019 Jan 2.

d Medical Faculty, Department of Dermatology , Yildirim Beyazit University , Ankara , Turkey.

Background: Rosacea is the chronic inflammatory disease of the facial skin. Although its aetiology is not clear yet, inflammatory processes triggered by oxidative stress and oxidation of lipids have been suggested to play a role. While studies on the relationship between inflammation and oxidative stress are ongoing, thiol metabolism and its role in oxidative stress have also begun to be investigated. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1517124DOI Listing
March 2019
12 Reads
0.920 Impact Factor

Tier-based skin irritation testing of hair cleansing conditioners and their constituents.

Cutan Ocul Toxicol 2019 Mar 26;38(1):44-47. Epub 2018 Nov 26.

b Cardno ChemRisk , San Francisco , CA , USA.

Purpose/Aim: The U.S. Food and Drug Administration (FDA) does not require specific testing to demonstrate the safety of personal care and cosmetic products or their ingredients. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1512610DOI Listing
March 2019
20 Reads

3,5-Dimethoxy-4-hydroxy myricanol ameliorates photoreceptor cell degeneration in Pde6b mouse model.

Cutan Ocul Toxicol 2019 Mar 2;38(1):36-43. Epub 2018 Oct 2.

a Department of Ophthalmology , Second Hospital of Jilin University, Jilin University , Changchun , People's Republic of China.

Introduction: Retinitis pigmentosa (RP) caused by the photoreceptor cell degeneration is currently incurable and leads to partial or complete blindness eventually. 3,5-dimethoxy-4-hydroxy myricanol (DM) is a novel compound isolated from the leaves of Micromelum integerrimum, with proliferative activities on NIH3T3 cells. This study was to investigate whether DM could mitigate retinal degeneration of rd10 mice, a well-characterized mouse model of RP. Read More

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http://dx.doi.org/10.1080/15569527.2018.1508153DOI Listing
March 2019
3 Reads

Characterization of dry skin associating with type 2 diabetes mellitus using a KK-A/TaJcl mouse model.

Cutan Ocul Toxicol 2018 Dec 31;37(4):391-395. Epub 2018 Jul 31.

a Faculty of Pharmaceutical Science , Suzuka University of Medical Science , Suzuka , Japan.

Purpose: Type 2 diabetes mellitus (DM) induces various dermatological conditions that can affect patient quality of life, including increased susceptibility to skin infections and dry skin. While the mechanisms that underlie the causes of dry skin in type 1 DM have been widely studied, how type 2 DM elicits similar effects is unclear. The purpose of this study was therefore to evaluate skin barrier and hydration function using a KK-A/TaJcl mouse model of type 2 DM. Read More

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http://dx.doi.org/10.1080/15569527.2018.1490746DOI Listing
December 2018
4 Reads

Investigation of vascular endothelial dysfunction in the patients with age-related macular degeneration.

Cutan Ocul Toxicol 2019 Mar 11;38(1):29-35. Epub 2018 Sep 11.

c Cerrahpasa Medical Faculty, Department of Biostatistics and Medical Informatics , Istanbul University , Istanbul , Turkey.

Purpose: This study aims to evaluate the association between age-related macular degeneration (AMD) and cardiovascular disease by using the noninvasive flow-mediated dilation (FMD) test to show endothelial dysfunction as an indicator of subclinical atherosclerosis.

Method: Participants in this study included 30 dry AMD patients, 30 wet AMD patients, and 30 healthy controls without any systemic disease, including AMD. FMD and the intima media thickness (IMT) of the carotid artery were compared between the groups. Read More

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http://dx.doi.org/10.1080/15569527.2018.1504056DOI Listing
March 2019
12 Reads

Evaluation of a tiered in vitro testing strategy for assessing the ocular and dermal irritation/corrosion potential of pharmaceutical compounds for worker safety.

Cutan Ocul Toxicol 2018 Dec 23;37(4):380-390. Epub 2018 Jul 23.

a Bristol-Myers Squibb Co. (BMS) , New Brunswick , NJ , USA.

Introduction: Irritation reactions are a frequently reported occupational illness. The potential adverse effects of pharmaceutical compounds (PCs) on eye and skin can now be assessed using validated in vitro methods.

Objectives: Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro test methods which accurately determine the ocular and dermal irritation/corrosion potential of PCs to inform worker safety within the pharmaceutical space. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1483944DOI Listing
December 2018
30 Reads

An evaluation of peripapillar choroidal thickness in patients receiving systemic isotretinoin treatment.

Cutan Ocul Toxicol 2019 Mar 21;38(1):25-28. Epub 2018 Sep 21.

b Department of Ophtalmology , Konya Training and Research Hospital , Konya , Turkey.

Purpose: Oral isotretinoin (13-cis retinoic acid, 13-cis RA) was approved for severe acne treatment by the FDA in 1982. The ocular side effects associated with oral isotretinoin use are mostly dose-dependent. Numerous ocular pathologies affect peripapillary choroidal layer primarily or indirectly. Read More

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http://dx.doi.org/10.1080/15569527.2018.1503289DOI Listing
March 2019
2 Reads

Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal model.

Cutan Ocul Toxicol 2019 Mar 11;38(1):18-24. Epub 2018 Sep 11.

f Department of Nuclear Medicine , Ankara Training and Research Hospital of University of Health Sciences , Ankara , Turkey.

Purpose: To evaluate antioxidant effects of active vitamin D (calcitriol) against high-dose radioiodine (RAI) therapy-associated damage of lacrimal gland.

Materials And Methods: Wistar albino rats were used and divided into three groups randomly (n = 12/group). The first group was appointed as the negative control group and received no RAI or medication. Read More

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http://dx.doi.org/10.1080/15569527.2018.1498507DOI Listing
March 2019
11 Reads

Ocular toxicity due to colours used during holi celebration in India: correlation of clinical findings with the anterior segment OCT.

Cutan Ocul Toxicol 2019 Mar 10;38(1):1-4. Epub 2018 Sep 10.

a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , All India Institute of Medical Sciences , New Delhi , India.

Purpose: To correlate the anatomical extent of ocular surface toxicity due to colours using anterior segment optical coherence tomography (ASOCT) with the clinical findings.

Methods: Patients presenting to our emergency department with ocular colour toxicity during the Holi festival celebrations from March 2 2018 to March 5 2018 were assessed for any adnexal, conjunctival, corneal, and anterior chamber findings, as well as findings on anterior segment optical coherence tomography.

Results: A total of 21 patients were observed. Read More

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http://dx.doi.org/10.1080/15569527.2018.1495225DOI Listing
March 2019
2 Reads
0.920 Impact Factor

Role of oxidative stress and antioxidant therapy in acute and chronic phases of sulfur mustard injuries: a review.

Cutan Ocul Toxicol 2019 Mar 10;38(1):9-17. Epub 2018 Sep 10.

a Chemical Injuries Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical Sciences , Tehran , Iran.

Sulfur mustard (SM) is a chemical compound that preferentially targets ocular, cutaneous and pulmonary tissues. Although pathologic effect of SM has been extensively considered, molecular and cellular mechanism of its toxicity, especially at the chronic phase of injury is not well-understood. Excessive production of reactive oxygen species (ROS) and oxidative stress (OS) appears to be involved in SM-induced injuries. Read More

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http://dx.doi.org/10.1080/15569527.2018.1495230DOI Listing
March 2019
42 Reads

Effects of Pycnogenol on cisplatin-induced optic nerve injury: an experimental study.

Cutan Ocul Toxicol 2018 Dec 10;37(4):396-400. Epub 2018 Sep 10.

c Department of Pharmacology , Erzincan University Hospital, College of Medicine , Erzincan , Turkey.

Aim: To determine the effects of Pycnogenol on cisplatin-induced optic nerve damage.

Material And Method: Totally 18 albino Wistar male rats were assigned into three groups, with six rats in each group as follows: healthy controls (HC group), only cisplatin (2.5 mg/kg) administered group (CIS group) and Pycnogenol (40 mg/kg) + cisplatin (2. Read More

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http://dx.doi.org/10.1080/15569527.2018.1495224DOI Listing
December 2018
22 Reads

The effect of omalizumab on hematological and inflammatory parameters in patients with chronic spontaneous urticaria.

Cutan Ocul Toxicol 2019 Mar 10;38(1):5-8. Epub 2018 Sep 10.

a Department of Dermatology , Eskişehir Osmangazi University , Eskişehir , Turkey.

Purpose: The mechanism of action of omalizumab in chronic spontaneous urticaria (CSU) is not exactly known. In previous studies, d-dimer which is a fibrin-degradation product and interleukin-31 which has a role in inflammation were found to be decreased in patients with chronic urticaria treated with omalizumab. However, to our knowledge, there is no study on the effects of omalizumab on the ratio of neutrophil to lymphocyte (NLR) and the ratio of platelet to lymphocyte (PLR) which are inflammatory parameters in patients with CSU in the PubMed database. Read More

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http://dx.doi.org/10.1080/15569527.2018.1495227DOI Listing
March 2019
23 Reads

Tandem Repeated Irritation Test (TRIT) Studies and Clinical Relevance: Post 2006.

Cutan Ocul Toxicol 2018 Jun 11:1-17. Epub 2018 Jun 11.

b Department of Dermatology , University of California , San Francisco , CA , USA.

Background/aims: Single or multiple applications of irritants can lead to occupational contact dermatitis, and most commonly irritant contact dermatitis (ICD). Tandem irritation, the sequential application of two irritants to a target skin area, has been studied using the Tandem Repeated Irritation Test (TRIT) to provide a more accurate representation of skin irritation.

Objective: Here we present an update to Kartono's review on tandem irritation studies since 2006 [1]. Read More

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http://dx.doi.org/10.1080/15569527.2018.1486853DOI Listing
June 2018
28 Reads

The effects of lutein on cisplatin-induced retinal injury: an experimental study.

Cutan Ocul Toxicol 2018 Dec 23;37(4):374-379. Epub 2018 Jul 23.

e Department of Pharmacology , Faculty of Medicine, Erzincan University , Erzincan , Turkey.

Aim: Lutein is one of the most common carotenoids defined in human plasma as having potent anti-oxidant effects. We aimed to determine the biochemical and histopathological effects of lutein on cisplatin-induced oxidative retinal injury in rats.

Materials And Methods: Twenty-four rats were equally divided into four groups as healthy controls (HC group), only cisplatin (5 mg/kg) administered group (CIS group), Lutein (0. Read More

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http://dx.doi.org/10.1080/15569527.2018.1482494DOI Listing
December 2018
2 Reads
0.920 Impact Factor

The intraocular staining potential of anthocyanins and their retinal biocompatibility: a preclinical study.

Cutan Ocul Toxicol 2018 Dec 4;37(4):359-366. Epub 2018 Jun 4.

b College of Medicine , Chang Gung University , Taoyuan , Taiwan.

Purpose: To perform preclinical studies to determine the efficacy and safety of anthocyanins as stains for the internal limiting membrane (ILM) of the eye.

Materials And Methods: Cyanidin (Cya), delphinidin (Del), luteolinidin (Lut), peonidin (Peo) and pelargonidin (Pel) were evaluated. These natural dyes were used to stain the lens capsule and ILM of pig eyes. Read More

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http://dx.doi.org/10.1080/15569527.2018.1471698DOI Listing
December 2018
3 Reads