781 results match your criteria Cutaneous and Ocular Toxicology [Journal]


Acute Effect of Caffeine on Pattern-Reversal Visual Evoked Potential: A Randomized-Controlled Study.

Cutan Ocul Toxicol 2019 Feb 22:1-12. Epub 2019 Feb 22.

c Ege University Medical Faculty, Department of Neurology , Izmir , Turkey.

Purpose: This study was aimed to investigate the acute effect of caffeine intake on pattern-reversal (PR) visual evoked potential (VEP).

Methods: This randomized controlled study included 40 participants who were divided into two groups randomly (group 1 [study group, n = 20] and group 2 [control group, n = 20]). While the study group received coffee beverages made from 6 grams pure coffee beans (36 mg of caffeine per gram) containing approximately 216 mg caffeine, the control group was given beverages containing 200 mg lactose without caffeine. Read More

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http://dx.doi.org/10.1080/15569527.2019.1583248DOI Listing
February 2019

The Impact of Intravitreal Dexamethasone Implant (Ozurdex®) on Retrobulbar Hemodynamics in Patients with Diabetic Macular Edema and Retinal Vein Occlusions.

Cutan Ocul Toxicol 2019 Feb 17:1-23. Epub 2019 Feb 17.

a Department of Ophthalmology , Ministry of Health - Ordu University Research and Training Hospital , Ordu , 52200 / Turkey.

Objective: To evaluate the effect of single intravitreal Dexamethasone implant (Ozurdex®) on ocular blood flow velocities in patients with diabetic macular edema (DME) and retinal vein occlusions (RVO).

Methods: This prospective non-randomized interventional study included injected and fellow eyes of 12 patients with diabetic macular edema (DME) and of 16 patients with retinal vein occlusion (RVO) treated with intravitreal Ozurdex®. Color Doppler Ultrasonography (CDU) measures of the central retinal artery (CRA), posterior ciliary artery (PCA), ophthalmic artery (OA) those are peak systolic velocity (PSV), end diastolic velocity (EDV), resistive index (RI) and pulsatility index (PI) were performed in both injected and uninjected eyes before injection, at one week, one month after injection, and prior to re-injection. Read More

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http://dx.doi.org/10.1080/15569527.2019.1582061DOI Listing
February 2019

Topical Application of Povidone-Iodine/Dimethylsulfoxide Ophthalmic Gel Preparation in Dutch-Belted Rabbits.

Cutan Ocul Toxicol 2019 Feb 10:1-11. Epub 2019 Feb 10.

a Veloce BioPharma LLC , Fort Lauderdale , FL.

Purpose: To determine the ocular and systemic toxicity of a novel, topically applied ophthalmic gel preparation of povidone-iodine and dimethylsulfoxide in Dutch-Belted rabbits.

Materials And Methods: Rabbits were administered doses of the test material or control by ocular instillation four times/eye/day, seven days/week, for a minimum of 14 consecutive days. Dosing consisted of instillation of 50 µl of the appropriate test material solution or control material (saline) into each eye of the rabbit. Read More

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http://dx.doi.org/10.1080/15569527.2019.1579225DOI Listing
February 2019
1 Read

Therapeutic Effects of Three Human-derived Materials in a Mouse Corneal Alkali Burn Model.

Cutan Ocul Toxicol 2019 Feb 10:1-24. Epub 2019 Feb 10.

e Department of Ophthalmology , Ewha Womans University Mok-dong Hospital , Mok-dong, Yangcheon-gu , Seoul , Korea, Republic of.

Purpose: To compare the therapeutic effects of human derivatives in a mouse alkali burn model.

Methods: The right eyes of mice were injured using NaOH. After alkali injury, one of the following agents was topically administered for 7 days: human amniotic membrane (hAM) suspension, human umbilical cord serum (hUCS), and human peripheral blood serum (hPBS), or saline. Read More

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http://dx.doi.org/10.1080/15569527.2019.1573244DOI Listing
February 2019

The Effect of Voluntary Fasting and Dehydration on Posterior Ocular Structures.

Authors:
Zeynep Duru

Cutan Ocul Toxicol 2019 Feb 6:1-19. Epub 2019 Feb 6.

a Department of Ophthalmology , Kayseri Education and Research Hospital , Kayseri , Turkey.

Purpose: Islamic Ramadan is the month of fasting, in which intake of food and drink is restricted from sunrise until sunset. The objective of the present study was to find out the effects of religious fasting on posterior ocular structures.

Materials And Methods: In this prospective study, 34 eyes of 34 healthy volunteers with a mean age of 34. Read More

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http://dx.doi.org/10.1080/15569527.2019.1573245DOI Listing
February 2019
1 Read

Direct and crossover effects of brinzolamide, betaxolol, and latanoprost on choroidal thickness.

Cutan Ocul Toxicol 2019 Feb 5:1-13. Epub 2019 Feb 5.

a Recep Tayyip Erdoğan Üniversitesi Zihni Derin Yerleşkesi - Fener Mahallesi 53100 Merkez/RİZE , TR 53100.

Purpose: To investigate the acute effects of brinzolamide, betaxolol, and latanoprost (drugs commonly used in the medical management of glaucoma) on choroidal thickness using enhanced depth imaging optical coherence tomography (EDI-OCT).

Methods: Ninety healthy volunteers were evaluated in this prospective study. Participants were randomly divided into 3 groups. Read More

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http://dx.doi.org/10.1080/15569527.2019.1575390DOI Listing
February 2019

The Safety of Intraocular Usage of Aspirin.

Cutan Ocul Toxicol 2019 Feb 5:1-20. Epub 2019 Feb 5.

a Department of Ophthalmology, Cerrahpaşa Medical Faculty , Istanbul University- Cerrahpaşa , Istanbul , Turkey.

Purpose: To determine the effects of intravitreally injected aspirin on normal ocular tissues.

Methods: Six eyes of 3 rabbits as control group, 18 eyes of 9 albino rabbits which were injected aspirin intravitreally were studied. In the control group, the same volume of balanced salt solution (BSS) as in drug groups were injected. Read More

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http://dx.doi.org/10.1080/15569527.2019.1575391DOI Listing
February 2019
1 Read

Antioxidant Effects of Piperine In In-vivo Chick Embryo Cataract Model Induced by Steroids.

Cutan Ocul Toxicol 2019 Jan 24:1-26. Epub 2019 Jan 24.

c The Department of the Anatomy , Afyonkarahisar Health Sciences University , Afyonkarahisar , Turkey.

Purpose: The etiopathogenesis of steroid-induced cataracts is unknown. One hypotheseis is that the higher reactive oxygen species (ROS) levels. ROS plays an important role in the pathogenesis of several disorders, including the evolution of cataracts. Read More

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http://dx.doi.org/10.1080/15569527.2019.1570521DOI Listing
January 2019
1 Read

Phytodermatitis in East and southeast of Turkey: A prospective study.

Authors:
Isa An Murat Ozturk

Cutan Ocul Toxicol 2018 Dec 26:1-6. Epub 2018 Dec 26.

b Department of Dermatology , Health Sciences Universty Van Training and Research Hospital , Van , Turkey.

Objective: Some plants may cause cutaneous side effects called phytodermatitis due to skin contact. Plants that cause phytodermatitis vary according to countries and regions. The aim of this study was to examine the phytodermatitis cases seen in Turkey's east and southeast and compare them with phytodermatitis cases seen previously in the literature in these provinces and to revise the literature. Read More

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http://dx.doi.org/10.1080/15569527.2018.1561711DOI Listing
December 2018
4 Reads

Evaluation of formaldehyde as an ocular irritant: a systematic review and Meta-analysis.

Cutan Ocul Toxicol 2018 Dec 26:1-7. Epub 2018 Dec 26.

d Grade of Nurse , Hospital Dr Peset , Valencia , Spain.

Objective: The aim of this study was to use meta-regression to evaluate the safety of the maximum allowable dose of formaldehyde in terms of eye irritation symptoms.

Methods: We performed a systematic review of literature published in the PubMed, Embase, Lilacs, Web of Science, and Cochrane Library databases. We selected clinical trials, cohort studies, and case-control studies that compared eye irritation between patients exposed and not exposed to formaldehyde. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1561709DOI Listing
December 2018
10 Reads

Audit of toxic effects of body paint in the tiger dancers (Hulivesha) of Mangalore, India: an investigational study.

Cutan Ocul Toxicol 2018 Dec 2:1-7. Epub 2018 Dec 2.

c Father Muller Research Centre, Father Muller Charitable Institutions , Mangalore , India.

Introduction: Tiger dancing or Hulivesha, where the volunteers paint their bare body like a tiger and dance in a ritual during the Navarathri festival in Mangalore, India. There are no scientific studies done with the Hulivesha dancers at all, and therefore, we investigated the adverse effects of painting body like a tiger and dancing in the volunteers.

Objective/aim: In this study, we investigated the clinico-haematological effects of topical application of lead-containing paint and dancing for three consecutive days in these dancers to ascertain the toxic effects of whole body painting and dancing. Read More

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http://dx.doi.org/10.1080/15569527.2018.1529036DOI Listing
December 2018
4 Reads

The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis.

Cutan Ocul Toxicol 2018 Dec 2:1-7. Epub 2018 Dec 2.

a Department of Pharmacy , Renmin Hospital of Wuhan University , Wuhan , Hubei , P.R. China.

Background: This meta-analysis was conducted to assess the risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients.

Methods: We considered relevant prospective randomized phase I, II, and III trials of melanoma patients on the combined BRAF and MEK inhibition versus BRAF inhibition, describing events of rash, photosensitivity reaction (PR), hyperkeratosis (HK), alopecia, cutaneous squamous-cell carcinom(cSCC), skin papilloma(SP), pruritus, and hand-foot syndrome(HFS), as eligible for inclusion.

Results: Eight trials comprising 3163 patients were included in the meta-analysis. Read More

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http://dx.doi.org/10.1080/15569527.2018.1553180DOI Listing
December 2018
1 Read

(3R, 3'R)-zeaxanthin protects the retina from photo-oxidative damage via modulating the inflammation and visual health molecular markers.

Cutan Ocul Toxicol 2018 Dec 4:1-8. Epub 2018 Dec 4.

g Research and Development, OmniActive Health Technologies Inc , Morristown , NJ , USA.

Purpose: Zeaxanthin protects the macula from ocular damage due to light or radiation by scavenging harmful reactive oxygen species. In the present study, zeaxanthin product (OmniXan®; OMX), derived from paprika pods (Capsicum annum; Family-Solanaceae), was tested for its efficacy in the rat retina against photooxidation.

Methods: Forty-two male 8-week-old Wistar rats exposed to 12L/12D, 16L/8D and 24L/0D hours of intense light conditions were orally administrated either 0 or 100 mg/kg BW of zeaxanthin concentration. Read More

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http://dx.doi.org/10.1080/15569527.2018.1554667DOI Listing
December 2018
3 Reads

United States regulatory requirements for skin and eye irritation testing.

Cutan Ocul Toxicol 2018 Nov 11:1-58. Epub 2018 Nov 11.

a Integrated Laboratory Systems, Inc. , PO Box 13501 , Research Triangle Park , NC 27709 , USA.

Purpose: Eye and skin irritation test data are required or considered by chemical regulation authorities in the United States to develop product hazard labeling and/or to assess risks for exposure to skin- and eye-irritating chemicals. The combination of animal welfare concerns and interest in implementing methods with greater human relevance has led to development of non-animal skin- and eye-irritation test methods. To identify opportunities for regulatory uses of non-animal replacements for skin and eye irritation tests, the needs and uses for these types of test data at U. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1540494DOI Listing
November 2018
10 Reads

Safety of Sodium Hyaluronate Eye Drop with C12-Benzailonium Chloride.

Cutan Ocul Toxicol 2018 Nov 7:1-26. Epub 2018 Nov 7.

a Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences , Nagasaki University , 1-7-1 Sakamoto , Nagasaki , Nagasaki 852-8501 , Japan.

Purpose: In this study, we investigated the effects of commercially available multi-dose Sodium Hyaluronate 0.1% (Hyalein®; Santen, Osaka, Japan) containing 0.003% C12 benzalkonium chloride (BAC) on the corneal epithelial and its degree of safety. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1543316DOI Listing
November 2018
10 Reads

The effects of lutein on optic nerve injury induced by ethambutol and isoniazid: an experimental study.

Cutan Ocul Toxicol 2018 Nov 26:1-5. Epub 2018 Nov 26.

d Department of Biochemistry , Atatürk University , Erzurum , Turkey.

Aim: Ethambutol and isoniazid are two major effective first line agents in tuberculosis treatment having some visual adverse effects. We aimed to determine the protective effects of lutein on oxidative optic neuropathy induced by ethambutol and isoniazid in an experimental model.

Material And Method: Totally 24 albino Wistar male rats were assigned into 4 groups, with 6 rats in each group as follows: healthy controls (HC group), 50 mg/kg ethambutol +50 mg/kg isoniazid administered group (EI), 0. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1539010DOI Listing
November 2018
10 Reads
0.920 Impact Factor

Swept-source optical coherence tomography analysis in asthmatic children under inhaled corticosteroid therapy.

Cutan Ocul Toxicol 2018 Nov 23:1-5. Epub 2018 Nov 23.

d Department of Ophthalmology , Trabzon Kanuni Training and Research Hospital , Trabzon , Turkey.

Purpose: To evaluate retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), subfoveal choroidal thickness (SFCT), and central retinal thickness (CRT) in asthmatic children who were under inhaled corticosteroid treatment by using Swept-Source Optical Coherence Tomography (SS-OCT).

Material And Methods: Fifty-three children were prospectively analyzed in the study. Group 1 included 31 asthmatic children and group 2 included 22 healthy children. Read More

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http://dx.doi.org/10.1080/15569527.2018.1539009DOI Listing
November 2018
3 Reads

Evaluation of xenon, light-emitting diode (LED) and halogen light toxicity on cultured retinal pigment epithelial cells.

Cutan Ocul Toxicol 2018 Nov 23:1-6. Epub 2018 Nov 23.

d Department of Ophthalmology , Bezmialem Vakif University , Istanbul , Turkey.

Objective: To compare the possible toxic effects of three light sources used in vitreoretinal endoillumination systems; halogen, xenon, and light-emitting diode (LED) on retinal pigment epithelium (RPE) cell cultures, after two different exposure times.

Material And Methods: ARPE-19 human RPE cell cultures were exposed to halogen, xenon, and LED light sources at a distance of 1.5 cm for 30 and 60 min with equal lumen output levels. Read More

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http://dx.doi.org/10.1080/15569527.2018.1539008DOI Listing
November 2018
5 Reads

Long-term systemic administration with low dose of 3,4-methylenedioxymethamphetamine causes photoreceptor cell damage in CD1 mice.

Cutan Ocul Toxicol 2019 Mar 26;38(1):81-87. Epub 2018 Nov 26.

b Department of Ophthalmology , Shenzhen Children's Hospital , Shenzhen , People's Republic of China.

Objective: As a powerful psychostimulant with high potential for abuse, 3,4-methylenedioxymethamphetamine (MDMA) causes long-lasting neurotoxicity. This study was to investigate the effects of systemic administration of MDMA on retinal damage in CD1 mice and its underlying mechanisms.

Material And Methods: CD1 mice were randomly divided into two groups (n = 10): group 1 receiving PBS by intraperitoneal injection daily; group 2 receiving 2 mg/kg MDMA by intraperitoneal injection daily for 3 months. Read More

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http://dx.doi.org/10.1080/15569527.2018.1539007DOI Listing
March 2019
1 Read

Extracts of different pollen species and their effect on human tear fluid and an epithelial cell line.

Cutan Ocul Toxicol 2019 Mar 13;38(1):93-103. Epub 2018 Nov 13.

a Department of Ophthalmology , Medical University of Graz , Graz , Austria.

Purpose: Hazelnut and birch pollen are known to destroy tear film components and attack ocular surface cells. We investigated further pollen species from different plant families, whether they show similar effects on human tear fluid and an epithelial cell line in vitro, to provide a broad basis for further research on pollen reactions affecting the tear film and ocular surface.

Materials And Methods: Regional pollen species from different plant families (Adoxaceae, Betulaceae, Fagaceae, Juglandaceae, Malvaceae, Oleaceae, Pinaceae, Plantaginaceae, Poaceae, Salicaceae, Sapindaceae) were collected. Read More

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http://dx.doi.org/10.1080/15569527.2018.1530259DOI Listing
March 2019
4 Reads

The effects of lycopene on alloxan induced diabetic optic neuropathy.

Cutan Ocul Toxicol 2019 Mar 23;38(1):88-92. Epub 2018 Nov 23.

d Department of Pharmacology , Erzincan University Hospital, College of Medicine , Erzincan , Turkey.

Aim: To determine the effects of lycopene treatment in prevention of diabetes associated inflammatory response and oxidative stress in an experimental model. With this aim we investigated the levels of oxidative stress markers including Malondialdehyde (MDA), and total oxidative status (TOS)together with inflammatory markers including nuclear factor- kappa B (NFKB) and tumor necrosis factor α (TNF-α) and antioxidants including total glutathione (TGSH), total oxidative status (TOS) and total anti-oxidative status (TAS) levels on eye tissue.

Material And Methods: Totally 18 albino Wistar male rats (250-280 grams) assigned into three groups, with six rats in each group as follows: healthy group (HG), control group (CG), and lycopene group (LG). Read More

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http://dx.doi.org/10.1080/15569527.2018.1530258DOI Listing
March 2019
6 Reads

Toxicity assessment of six titanium dioxide nanoparticles in human epidermal keratinocytes.

Cutan Ocul Toxicol 2019 Mar 9;38(1):66-80. Epub 2019 Jan 9.

b Department of Anatomy and Physiology , Nanotechnology Innovation Center of Kansas State (NICKS), Kansas State University , Manhattan , KS , USA.

Purpose: The aim of this study was to evaluate and compare the toxicity of six different types of titanium dioxide (TiO) nanoparticles (NP) on human epidermal keratinocytes (HEK).

Materials And Methods: Six TiO NP (A (10 nm), A*(32 nm), B (27.5 nm), C (200 nm), C*(30-40 nm), and D*(200-400 nm)) were suspended in water or culture medium and characterized by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1527848DOI Listing
March 2019
9 Reads

The protective effects of astaxanthin against cisplatin-induced retinal toxicity.

Cutan Ocul Toxicol 2019 Mar 9;38(1):59-65. Epub 2019 Jan 9.

b Department of Histology and Embryology, Faculty of Medicine , Recep Tayyip Erdogan University , Rize , Turkey.

Purpose: This study investigated the toxic effects of an antineoplastic agent, cisplatin (CIS), on retinal cells and the potential capacity of astaxanthin (ASTA) to elicit a future therapeutic protocol in CIS-induced retinal toxicity.

Materials And Methods: Six groups were formed for the assessment; control (healthy; Group 1), olive oil (olive oil only; Group 2), ASTA control group (ASTA only, Group 3), the single intraperitoneal (IP) dose of 16 mg/kg CIS (CIS only group; Group 4), 16 mg/kg CIS +25 mg/kg (IP) ASTA (Group 5), and 16 mg/kg CIS +75 mg/kg (IP) ASTA (Group 6). On the third day after CIS administration, rats in all groups were sacrificed under anesthesia and the analysis of the biochemical parameters and histopathological levels were performed. Read More

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http://dx.doi.org/10.1080/15569527.2018.1518330DOI Listing
March 2019
2 Reads

Efficacy and safety of 2% supramolecular salicylic acid compared with 5% benzoyl peroxide/0.1% adapalene in the acne treatment: a randomized, split-face, open-label, single-center study.

Cutan Ocul Toxicol 2019 Mar 20;38(1):48-54. Epub 2018 Dec 20.

a Department of Dermatology , The Third affiliated Hospital of Sun Yat-sen University , Guangzhou , China.

Background: Topical drugs for mild to moderate acne include adapalene (ADA) and benzoyl peroxide(BPO). Supramolecular salicylic acid (SSA), a modified SA preparation, is considered as a new effective therapeutic scheme.

Objectives: To compare the safety and efficacy of 2% supramolecular SA (2% SSA) with 0. Read More

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http://dx.doi.org/10.1080/15569527.2018.1518329DOI Listing
March 2019
5 Reads

Thiol/disulfide homeostasis as a marker of oxidative stress in rosacea: a controlled spectrophotometric study.

Cutan Ocul Toxicol 2019 Mar 2;38(1):55-58. Epub 2019 Jan 2.

d Medical Faculty, Department of Dermatology , Yildirim Beyazit University , Ankara , Turkey.

Background: Rosacea is the chronic inflammatory disease of the facial skin. Although its aetiology is not clear yet, inflammatory processes triggered by oxidative stress and oxidation of lipids have been suggested to play a role. While studies on the relationship between inflammation and oxidative stress are ongoing, thiol metabolism and its role in oxidative stress have also begun to be investigated. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1517124DOI Listing
March 2019
12 Reads
0.920 Impact Factor

Tier-based skin irritation testing of hair cleansing conditioners and their constituents.

Cutan Ocul Toxicol 2019 Mar 26;38(1):44-47. Epub 2018 Nov 26.

b Cardno ChemRisk , San Francisco , CA , USA.

Purpose/Aim: The U.S. Food and Drug Administration (FDA) does not require specific testing to demonstrate the safety of personal care and cosmetic products or their ingredients. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1512610DOI Listing
March 2019
15 Reads

3,5-Dimethoxy-4-hydroxy myricanol ameliorates photoreceptor cell degeneration in Pde6b mouse model.

Cutan Ocul Toxicol 2019 Mar 2;38(1):36-43. Epub 2018 Oct 2.

a Department of Ophthalmology , Second Hospital of Jilin University, Jilin University , Changchun , People's Republic of China.

Introduction: Retinitis pigmentosa (RP) caused by the photoreceptor cell degeneration is currently incurable and leads to partial or complete blindness eventually. 3,5-dimethoxy-4-hydroxy myricanol (DM) is a novel compound isolated from the leaves of Micromelum integerrimum, with proliferative activities on NIH3T3 cells. This study was to investigate whether DM could mitigate retinal degeneration of rd10 mice, a well-characterized mouse model of RP. Read More

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http://dx.doi.org/10.1080/15569527.2018.1508153DOI Listing
March 2019
3 Reads

Characterization of dry skin associating with type 2 diabetes mellitus using a KK-A/TaJcl mouse model.

Cutan Ocul Toxicol 2018 Dec 31;37(4):391-395. Epub 2018 Jul 31.

a Faculty of Pharmaceutical Science , Suzuka University of Medical Science , Suzuka , Japan.

Purpose: Type 2 diabetes mellitus (DM) induces various dermatological conditions that can affect patient quality of life, including increased susceptibility to skin infections and dry skin. While the mechanisms that underlie the causes of dry skin in type 1 DM have been widely studied, how type 2 DM elicits similar effects is unclear. The purpose of this study was therefore to evaluate skin barrier and hydration function using a KK-A/TaJcl mouse model of type 2 DM. Read More

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http://dx.doi.org/10.1080/15569527.2018.1490746DOI Listing
December 2018
3 Reads

Investigation of vascular endothelial dysfunction in the patients with age-related macular degeneration.

Cutan Ocul Toxicol 2019 Mar 11;38(1):29-35. Epub 2018 Sep 11.

c Cerrahpasa Medical Faculty, Department of Biostatistics and Medical Informatics , Istanbul University , Istanbul , Turkey.

Purpose: This study aims to evaluate the association between age-related macular degeneration (AMD) and cardiovascular disease by using the noninvasive flow-mediated dilation (FMD) test to show endothelial dysfunction as an indicator of subclinical atherosclerosis.

Method: Participants in this study included 30 dry AMD patients, 30 wet AMD patients, and 30 healthy controls without any systemic disease, including AMD. FMD and the intima media thickness (IMT) of the carotid artery were compared between the groups. Read More

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http://dx.doi.org/10.1080/15569527.2018.1504056DOI Listing
March 2019
9 Reads

Evaluation of a tiered in vitro testing strategy for assessing the ocular and dermal irritation/corrosion potential of pharmaceutical compounds for worker safety.

Cutan Ocul Toxicol 2018 Dec 23;37(4):380-390. Epub 2018 Jul 23.

a Bristol-Myers Squibb Co. (BMS) , New Brunswick , NJ , USA.

Introduction: Irritation reactions are a frequently reported occupational illness. The potential adverse effects of pharmaceutical compounds (PCs) on eye and skin can now be assessed using validated in vitro methods.

Objectives: Our overall aim is to reduce animal testing by replacing the historically utilized in vivo test methods with validated in vitro test methods which accurately determine the ocular and dermal irritation/corrosion potential of PCs to inform worker safety within the pharmaceutical space. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1483944DOI Listing
December 2018
23 Reads

An evaluation of peripapillar choroidal thickness in patients receiving systemic isotretinoin treatment.

Cutan Ocul Toxicol 2019 Mar 21;38(1):25-28. Epub 2018 Sep 21.

b Department of Ophtalmology , Konya Training and Research Hospital , Konya , Turkey.

Purpose: Oral isotretinoin (13-cis retinoic acid, 13-cis RA) was approved for severe acne treatment by the FDA in 1982. The ocular side effects associated with oral isotretinoin use are mostly dose-dependent. Numerous ocular pathologies affect peripapillary choroidal layer primarily or indirectly. Read More

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http://dx.doi.org/10.1080/15569527.2018.1503289DOI Listing
March 2019
2 Reads

Antioxidant effects of vitamin D on lacrimal glands against high dose radioiodine-associated damage in an animal model.

Cutan Ocul Toxicol 2019 Mar 11;38(1):18-24. Epub 2018 Sep 11.

f Department of Nuclear Medicine , Ankara Training and Research Hospital of University of Health Sciences , Ankara , Turkey.

Purpose: To evaluate antioxidant effects of active vitamin D (calcitriol) against high-dose radioiodine (RAI) therapy-associated damage of lacrimal gland.

Materials And Methods: Wistar albino rats were used and divided into three groups randomly (n = 12/group). The first group was appointed as the negative control group and received no RAI or medication. Read More

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http://dx.doi.org/10.1080/15569527.2018.1498507DOI Listing
March 2019
10 Reads

Ocular toxicity due to colours used during holi celebration in India: correlation of clinical findings with the anterior segment OCT.

Cutan Ocul Toxicol 2019 Mar 10;38(1):1-4. Epub 2018 Sep 10.

a Dr. Rajendra Prasad Centre for Ophthalmic Sciences , All India Institute of Medical Sciences , New Delhi , India.

Purpose: To correlate the anatomical extent of ocular surface toxicity due to colours using anterior segment optical coherence tomography (ASOCT) with the clinical findings.

Methods: Patients presenting to our emergency department with ocular colour toxicity during the Holi festival celebrations from March 2 2018 to March 5 2018 were assessed for any adnexal, conjunctival, corneal, and anterior chamber findings, as well as findings on anterior segment optical coherence tomography.

Results: A total of 21 patients were observed. Read More

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http://dx.doi.org/10.1080/15569527.2018.1495225DOI Listing
March 2019
2 Reads
0.920 Impact Factor

Role of oxidative stress and antioxidant therapy in acute and chronic phases of sulfur mustard injuries: a review.

Cutan Ocul Toxicol 2019 Mar 10;38(1):9-17. Epub 2018 Sep 10.

a Chemical Injuries Research Center, Systems biology and poisonings institute, Baqiyatallah University of Medical Sciences , Tehran , Iran.

Sulfur mustard (SM) is a chemical compound that preferentially targets ocular, cutaneous and pulmonary tissues. Although pathologic effect of SM has been extensively considered, molecular and cellular mechanism of its toxicity, especially at the chronic phase of injury is not well-understood. Excessive production of reactive oxygen species (ROS) and oxidative stress (OS) appears to be involved in SM-induced injuries. Read More

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http://dx.doi.org/10.1080/15569527.2018.1495230DOI Listing
March 2019
38 Reads

Effects of Pycnogenol on cisplatin-induced optic nerve injury: an experimental study.

Cutan Ocul Toxicol 2018 Dec 10;37(4):396-400. Epub 2018 Sep 10.

c Department of Pharmacology , Erzincan University Hospital, College of Medicine , Erzincan , Turkey.

Aim: To determine the effects of Pycnogenol on cisplatin-induced optic nerve damage.

Material And Method: Totally 18 albino Wistar male rats were assigned into three groups, with six rats in each group as follows: healthy controls (HC group), only cisplatin (2.5 mg/kg) administered group (CIS group) and Pycnogenol (40 mg/kg) + cisplatin (2. Read More

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http://dx.doi.org/10.1080/15569527.2018.1495224DOI Listing
December 2018
16 Reads

The effect of omalizumab on hematological and inflammatory parameters in patients with chronic spontaneous urticaria.

Cutan Ocul Toxicol 2019 Mar 10;38(1):5-8. Epub 2018 Sep 10.

a Department of Dermatology , Eskişehir Osmangazi University , Eskişehir , Turkey.

Purpose: The mechanism of action of omalizumab in chronic spontaneous urticaria (CSU) is not exactly known. In previous studies, d-dimer which is a fibrin-degradation product and interleukin-31 which has a role in inflammation were found to be decreased in patients with chronic urticaria treated with omalizumab. However, to our knowledge, there is no study on the effects of omalizumab on the ratio of neutrophil to lymphocyte (NLR) and the ratio of platelet to lymphocyte (PLR) which are inflammatory parameters in patients with CSU in the PubMed database. Read More

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http://dx.doi.org/10.1080/15569527.2018.1495227DOI Listing
March 2019
14 Reads

Tandem Repeated Irritation Test (TRIT) Studies and Clinical Relevance: Post 2006.

Cutan Ocul Toxicol 2018 Jun 11:1-17. Epub 2018 Jun 11.

b Department of Dermatology , University of California , San Francisco , CA , USA.

Background/aims: Single or multiple applications of irritants can lead to occupational contact dermatitis, and most commonly irritant contact dermatitis (ICD). Tandem irritation, the sequential application of two irritants to a target skin area, has been studied using the Tandem Repeated Irritation Test (TRIT) to provide a more accurate representation of skin irritation.

Objective: Here we present an update to Kartono's review on tandem irritation studies since 2006 [1]. Read More

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http://dx.doi.org/10.1080/15569527.2018.1486853DOI Listing
June 2018
21 Reads

The effects of lutein on cisplatin-induced retinal injury: an experimental study.

Cutan Ocul Toxicol 2018 Dec 23;37(4):374-379. Epub 2018 Jul 23.

e Department of Pharmacology , Faculty of Medicine, Erzincan University , Erzincan , Turkey.

Aim: Lutein is one of the most common carotenoids defined in human plasma as having potent anti-oxidant effects. We aimed to determine the biochemical and histopathological effects of lutein on cisplatin-induced oxidative retinal injury in rats.

Materials And Methods: Twenty-four rats were equally divided into four groups as healthy controls (HC group), only cisplatin (5 mg/kg) administered group (CIS group), Lutein (0. Read More

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http://dx.doi.org/10.1080/15569527.2018.1482494DOI Listing
December 2018
2 Reads
0.920 Impact Factor

The intraocular staining potential of anthocyanins and their retinal biocompatibility: a preclinical study.

Cutan Ocul Toxicol 2018 Dec 4;37(4):359-366. Epub 2018 Jun 4.

b College of Medicine , Chang Gung University , Taoyuan , Taiwan.

Purpose: To perform preclinical studies to determine the efficacy and safety of anthocyanins as stains for the internal limiting membrane (ILM) of the eye.

Materials And Methods: Cyanidin (Cya), delphinidin (Del), luteolinidin (Lut), peonidin (Peo) and pelargonidin (Pel) were evaluated. These natural dyes were used to stain the lens capsule and ILM of pig eyes. Read More

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http://dx.doi.org/10.1080/15569527.2018.1471698DOI Listing
December 2018
3 Reads

Tetracaine induces apoptosis through a mitochondrion-dependent pathway in human corneal stromal cells in vitro.

Cutan Ocul Toxicol 2018 Dec 9;37(4):350-358. Epub 2018 May 9.

a Laboratory for Corneal Tissue Engineering , College of Marine Life Sciences, Ocean University of China , Qingdao , Shandong province , P. R. China.

Purpose: Tetracaine is a local anesthetic widely used in ocular diagnosis and ophthalmic surgery and may lead to some adverse effects and complications at a clinical dose. To assess the cytotoxicity and molecular toxicity mechanisms of tetracaine, we used human corneal stromal (HCS) cells as an in vitro model to study the effects of tetracaine on HCS cells.

Materials And Methods: The cytotoxicity of tetracaine on HCS cells was investigated by examining the changes of cell growth, morphology, viability and cell cycle progressing when HCS cells were treated with tetracaine at concentrations from 10 g/L to 0. Read More

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http://dx.doi.org/10.1080/15569527.2018.1468342DOI Listing
December 2018
3 Reads

Undeclared Formaldehyde Levels in Patient Consumer Products: Formaldehyde Test Kit Utility.

Cutan Ocul Toxicol 2018 May 3:1-18. Epub 2018 May 3.

b Department of Dermatology , School of Medicine, University of California-San Francisco , San Francisco , CA , USA.

Formaldehyde allergic contact dermatitis (ACD) may be due to products with free formaldehyde or formaldehyde-releasing agents, however, assessment of formaldehyde levels in such products is infrequently conducted. The present study quantifies total releasable formaldehyde from "in-use" products associated with formaldehyde ACD and tests the utility of commercially available formaldehyde spot test kits. Personal care products from 2 patients with ACD to formaldehyde were initially screened at the clinic for formaldehyde using a formaldehyde spot test kit. Read More

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http://dx.doi.org/10.1080/15569527.2018.1471485DOI Listing
May 2018
5 Reads

Central scotoma in tobacco-alcohol toxic optic neuropathy measured with semi-automated kinetic perimetry.

Cutan Ocul Toxicol 2018 Dec 24;37(4):319-323. Epub 2018 Apr 24.

a Department of General Ophthalmology , Medical University , Lublin , Poland.

Purpose: To measure the area of central scotoma obtained with semi-automated kinetic perimetry (SKP) in patients suffering from tobacco-alcohol toxic neuropathy (TATN).

Methods: Twelve eyes of six patients with TATN were examined with SKP. Area of central scotoma was measured in square degrees (deg). Read More

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http://dx.doi.org/10.1080/15569527.2018.1459666DOI Listing
December 2018
8 Reads

Investigation on aetiological factors in patients with hyperhidrosis.

Cutan Ocul Toxicol 2018 Dec 7;37(4):344-349. Epub 2018 May 7.

a Department of Dermatology , Ministry of Health Atatürk Training and Research Hospital , Ankara , Turkey.

Background: Hyperhidrosis is a condition where the amount of sweat released to skin surface increases due to the over-active eccrine sweat glands. Hyperhidrosis causes considerable psychosocial distress in affected people. It affects the quality of life and leads to social anxiety disorders. Read More

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http://dx.doi.org/10.1080/15569527.2018.1466897DOI Listing
December 2018
7 Reads

Osmolyte taurine induction in UVA exposed human retinal pigment epithelial cells.

Cutan Ocul Toxicol 2018 Dec 3;37(4):338-343. Epub 2018 May 3.

a Department of Ophthalmology , The First Affiliated Hospital of Jinzhou Medical University , Jinzhou , P.R. China.

Aim: To explore the osmolytes expression in ultraviolet (UVA) stressed human retinal pigment epithelial cells.

Methods: Osmolyte transporters and vascular endothelial growth factor (VEGF) messenger RNA (mRNA) were determined by real time polymerase chain reaction (PCR). Osmolyte uptake was measured by radioimmunoassay. Read More

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http://dx.doi.org/10.1080/15569527.2018.1465078DOI Listing
December 2018
5 Reads

Acute intensive care unit management of mustard gas victims: the Turkish experience.

Cutan Ocul Toxicol 2018 Dec 7;37(4):332-337. Epub 2018 May 7.

b Department of Medical CBRN Defense , University of Health Sciences , Etlik/Ankara , Turkey.

Purpose: Sulphur mustard (SM) is an highly toxic and vesicant chemical weapon that was used in various military conflicts several times in the history. The severity of ocular, dermal, and pulmonary symptoms that may appear following a characteristic asymptomatic period are depending on the SM concentration and exposure duration. The aim of this study is to present the clinical features and share the intensive care unit (ICU) experiences for the medical management of mustard gas victims. Read More

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https://www.tandfonline.com/doi/full/10.1080/15569527.2018.1
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http://dx.doi.org/10.1080/15569527.2018.1464018DOI Listing
December 2018
16 Reads

Topically applied 1% voriconazole induces dysplastic changes on the ocular surface: animal study.

Cutan Ocul Toxicol 2018 Dec 26;37(4):328-331. Epub 2018 Apr 26.

d Department of Laboratory Animals Science , Dokuz Eylul University, Institute of Health Science , Izmir , Turkey.

Purpose: To identify the risk of inducing ocular surface dysplasia following topical administration of 1% voriconazole eye drop.

Methods: Fourteen noninflamed healthy eyes of 14 white adult New Zealand rabbits were included in the study. The rabbits were randomly divided into two groups comprised of 7 rabbits each. Read More

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http://dx.doi.org/10.1080/15569527.2018.1463237DOI Listing
December 2018
5 Reads

Influence of serous retinal detachment on the outcome of ranibizumab treatment in diabetic macular oedema.

Cutan Ocul Toxicol 2018 Dec 19;37(4):324-327. Epub 2018 Apr 19.

a Department of Ophthalmology , Haydarpasa Numune Training and Research Hospital , Istanbul , Turkey.

Purpose: The purpose of this study was to evaluate the influence of serous retinal detachment (SRD) on the outcome of intravitreal ranibizumab (IVR) therapy in diabetic macular oedema (DME).

Materials And Methods: Fifty-one eyes with cystoid macular oedema (CME) and SRD (study group) and 57 eyes with only CME (control group) that received pro re nata (PRN) IVR injections during a 6-month period were retrospectively evaluated. The outcome measures included changes in the central macular thickness (CMT) and best corrected visual acuity (BCVA) and injection numbers. Read More

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http://dx.doi.org/10.1080/15569527.2018.1459667DOI Listing
December 2018
14 Reads

Effects of cisplatin-5-fluorouracil combination therapy on oxidative stress, DNA damage, mitochondrial apoptosis, and death receptor signalling in retinal pigment epithelium cells.

Cutan Ocul Toxicol 2018 Sep 19;37(3):291-304. Epub 2018 Apr 19.

b Department of Medical Biology, Faculty of Medicine , Trakya University , Edirne , Turkey.

Aim: Combination therapies of cisplatin with 5-FU (PF) are an effective solution and have been widely used for the treatment of various categories of cancer including anal, gastrointestinal, and oral cancer, as well as head and neck tumors. The effects of combined PF treatment on vital intracellular signalling pathways in nontargeted cells remain unclear. The aim of this study is to explain the possible mechanisms by which combined PF treatment results in retinal toxicity and to investigate the effects of PF on important vital signalling pathways in ARPE 19 retinal pigmented epithelial cells. Read More

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http://dx.doi.org/10.1080/15569527.2018.1456548DOI Listing
September 2018
18 Reads

Efficacy and safety of low-concentration, bisulphite-containing, intracameral epinephrine and topical atropine treatments for the prevention of intraoperative floppy iris syndrome.

Cutan Ocul Toxicol 2018 Sep 3;37(3):286-290. Epub 2018 May 3.

c Department of Ophthalmology , Marmara University School of Medicine , Istanbul , Turkey.

Purpose: The aim of this study was to evaluate the efficacy and safety of topical atropine and topical atropine combined with intracameral low-concentration, bisulphite-containing epinephrine treatment for the prophylaxis of intraoperative floppy iris syndrome.

Materials And Methods: Seventy-two eyes of 55 male patients who were treated with alpha-adrenergic antagonist medications for benign prostatic hyperplasia were included in this study. Standard premedication with topical cyclopentolate, phenylephrine, tropicamide and ketorolac was applied to all of the patients. Read More

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http://dx.doi.org/10.1080/15569527.2018.1456448DOI Listing
September 2018
8 Reads

The effect of ocular lubricants containing benzalkonium chloride on nasal mucosal flora.

Cutan Ocul Toxicol 2018 Sep 6;37(3):305-308. Epub 2018 Apr 6.

b Department of Ophthalmology , Acibadem University School of Medicine, Atakent Education and Research Hospital , Kucukcekmece, Istanbul , Turkey.

Purpose: The effect of ocular artificial teardrop containing benzalkonium chloride (BAC) on nasal mucosa was investigated.

Materials And Methods: There were two different treatment trial groups. Each dry eye syndrome (DES) patient received the ocular lubricant treatment four times a day in both groups (one group containing BAC, the other group was not). Read More

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http://dx.doi.org/10.1080/15569527.2018.1456549DOI Listing
September 2018
7 Reads
0.920 Impact Factor