5,944 results match your criteria Cutaneous Tuberculosis


Histological and immunohistochemical features suggesting aetiological differences in lymph node and (muco)cutaneous feline tuberculosis lesions.

J Small Anim Pract 2021 Jun 7. Epub 2021 Jun 7.

*Royal (Dick) School of Veterinary Studies and The Roslin Institute, The University of Edinburgh, Easter Bush, Midlothian, EH25 9RG, UK.

Objectives: To identify and describe histological and immunohistochemical criteria that may differentiate between skin and lymph node lesions associated with Mycobacterium (M.) bovis and M. microti in a diagnostic pathology setting. Read More

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Diagnostic Dilemma of Cutaneous Tuberculosis: Opening of the Pandora's Box.

Am J Dermatopathol 2021 Jun 2. Epub 2021 Jun 2.

Departments of Histopathology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India; and Department of Dermatology, Safdarjung Hospital, New Delhi, India.

Abstract: Tuberculosis in all forms, that is, pulmonary (PTB) or extrapulmonary (EPTB), is a universal health problem. Cutaneous tuberculosis (CTb) remains one of the least studied and often under-reported variants of EPTB because of its wide and protean clinical presentation. The diagnosis of CTb remains challenging because of lack of sensitive and specific investigations for its diagnosis. Read More

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Cutaneous tuberculosis on the scalp: a case report.

Infez Med 2021 Jun;29(2):263-267

Department of Internal Medicine, Hospital de Clínicas da Universidade Federal do Paraná, Curitiba, Brazil.

Tuberculosis is a disease that usually affects the lungs, although other systems may also be infected, resulting in atypical clinical presentations. We report the case of a 76-year-old man who was admitted to the hospital in Brazil with a 3-week history of a painful, enlarging ulcer on the scalp and cough. His medical history was notable for non-metastatic prostatic adenocarcinoma and esophageal squamous cell carcinoma. Read More

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Cutaneous tuberculosis in children from the northeastern region of Morocco.

Arch Pediatr 2021 May 22. Epub 2021 May 22.

Dermatology Department of the University Hospital Center Hassan II, Fez, Morocco; School of Medicine and Pharmacy, Fez, Morocco.

Introduction: In Morocco, tuberculosis is an endemic disease. The aim of this study was to trace the epidemiological, paraclinical, therapeutic, and progressive characteristics of cutaneous tuberculosis (CT) in children.

Materials And Method: This multicenter retrospective and prospective study concerned all pediatric patients followed for CT in our region. Read More

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Sporotrichoid distributed tuberculous panniculitis as a late complication of intravesical Bacillus Calmette-Guérin (BCG) immunotherapy.

Int J Infect Dis 2021 May 10. Epub 2021 May 10.

Department of Dermatology, Cliniques universitaires Saint-Luc, Université catholique de Louvain (UCLouvain), Avenue Hippocrate 10, 1200, Brussels, Belgium. Electronic address:

An 82-year-old man presented with unilateral oedema of the right lower limb overlaid with multiple, sporotrichoid distributed, panniculitis lesions. These symptoms appeared in a context of immunodepression and were associated with significant weight loss and deteriorated general condition. Patient's medical history, the histological findings, PCR testing and bacterial culture led to a diagnosis of cutaneous tuberculosis due to Mycobacterium bovis. Read More

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[Scrofuloderma as Initial Presentation of Mycobacterium tuberculosis Infection].

Acta Med Port 2021 Mar 1;34(3):236. Epub 2021 Mar 1.

Serviço de Infecciologia. Hospital Garcia de Orta, EPE. Almada. Portugal.

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The Effectiveness of Vacuum-Assisted Closure Device in Managing Intramuscular Tuberculosis.

Adv Skin Wound Care 2021 Jun;34(6):330-333

At the King Fahad Hospital, Imam Abdulrahman Bin Faisal University, College of Medicine, Dammam, Saudi Arabia, Sharifah A. Othman, MBBS, is Surgery Resident, Thoracic Surgery Division; Tarek M. ElSharkawy, MD, is Pathology Consultant, Pathology Department; Doaa Alfaifi, MD, is Pathology Resident, Pathology Department; and Yasser Aljehani, MD, is Thoracic Surgery Consultant, Thoracic Surgery Division. Acknowledgment: The authors thank Dr Wasan Alalwan for collecting the patient's data. The authors have disclosed no financial relationships related to this article. Submitted May 28, 2020; accepted in revised form July 7, 2020.

Abstract: Tuberculosis (TB) is endemic to some geographic areas such as Africa, Eastern Europe, Asia, Latin America, and the Caribbean. It is called the great mimicker because of its diverse and variable presentation and affects almost every organ in the body with different symptomatology. Often, TB causes empyema necessitans, the rarest forms of which are intramuscular and cutaneous. Read More

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DOCK8-related Immunodeficiency Syndrome (DIDS): Report of Novel Mutations in Iranian Patients.

J Mol Neurosci 2021 May 4. Epub 2021 May 4.

Division of Medical Genetics, Tabriz Children's Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.

DOCK8 immunodeficiency syndrome (DIDS) is a rare autosomal recessive (AR) disorder characterized by elevated serum IgE levels, eosinophilia, recurrent cutaneous infections, severe eczema, and sinopulmonary and gastrointestinal infections. This syndrome is a multisystem disease that is associated with both immune deficiency and neurological complications. In this study, we describe the clinical characteristics of two Iranian patients with DOCK8 deficiency and propose possible mechanisms for this condition. Read More

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A Case Report of Tuberculosis in the Finger.

Cureus 2021 Mar 23;13(3):e14071. Epub 2021 Mar 23.

Medicine, Ministry of Health, Riyadh, SAU.

Tuberculosis is a chronic, infectious disease that predominantly affects the respiratory system. Of the least common extrapulmonary forms of the disease is cutaneous tuberculosis. We present an unusual case, which is of cutaneous tuberculosis in the finger, manifesting as an ulcerating, erythematous lesion. Read More

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Chronic suppurative skin lesions in a young woman.

BMJ 2021 04 21;373:n797. Epub 2021 Apr 21.

Department of Internal Medicine, Hospital Nacional Guido Valadares, Dili, Timor Leste.

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Swiss Cheese Loin: A Rare Initial Presentation of Pott's Spine.

Cureus 2021 Mar 15;13(3):e13912. Epub 2021 Mar 15.

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Spinal tuberculosis (TB) is the most common form of skeletal TB with an exceedingly diverse set of clinical presentations. Most often, there is a slow onset of the disease with patients presenting only with back pain. Although some patients can present later with neurological deficits or with compressive symptoms of an accompanying cold abscess, an initial presentation of a spontaneous cutaneous fistulization of a paraspinal abscess is rare. Read More

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Reintroduction of Antituberculous Drugs in Patients with Antituberculous Drug-Related Drug Reaction with Eosinophilia and Systemic Symptoms.

J Allergy Clin Immunol Pract 2021 Apr 16. Epub 2021 Apr 16.

Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Drug Safety Monitoring Center, Seoul National University Hospital, Seoul, Korea. Electronic address:

Background: Patients who suffered drug reaction with eosinophilia and systemic symptom (DRESS) during the treatment of tuberculosis (TB) commonly experience multidrug hypersensitivity reactions resulting in limited anti-TB drug choices. Therefore, reintroduction based on a desensitization protocol may be an option to resume anti-TB medication.

Objective: To evaluate the outcomes and safety of resuming anti-TB drugs according to reintroduction methods in patients with anti-TB drug-related DRESS. Read More

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Association between erythema nodosum/ erythema induratum of Bazin and Mycobacterium tuberculosis infection in Koreans.

Indian J Dermatol Venereol Leprol 2021 Mar 2:1-5. Epub 2021 Mar 2.

Department of Dermatology Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Background: Erythema nodosum and erythema induratum of Bazin are similar inflammatory diseases of the lower extremities. These are clinically distinguishable entities, though overlap can occur. Both diseases are reported to be related to Mycobacterium tuberculosis infection, but it is very difficult to identify Mycobacterium tuberculosis in skin lesions. Read More

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Scorfuloderma of cheek (a cutaneous tuberculosis colliquativa cutis): Case report.

Ann Med Surg (Lond) 2021 Apr 26;64:102257. Epub 2021 Mar 26.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, B.P 5696, Casablanca, Morocco.

Introduction: Scrofuloderma is the most common form of cutaneous tuberculosis. The facial location is unusual and requires special care.

Discussion: The diagnosis of cutaneous tuberculosis is difficult due to the polymorphism of the anatomo-clinical pictures as well as the difficulty of isolating the causal agent. Read More

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Epidemiology of Mucormycosis in India.

Microorganisms 2021 Mar 4;9(3). Epub 2021 Mar 4.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Mucormycosis is an angioinvasive disease caused by saprophytic fungi of the order Mucorales. The exact incidence of mucormycosis in India is unknown due to the lack of population-based studies. The estimated prevalence of mucormycosis is around 70 times higher in India than that in global data. Read More

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[Cutaneous tuberculosis affecting the buttock in an immunocompetent adult patient].

Pan Afr Med J 2020 31;37:390. Epub 2020 Dec 31.

Service de Dermatologie, Hôpital Aristide Le Dantec, Dakar, Sénégal.

Tuberculosis is an endemic disease in Senegal. It rarely affects the skin. In these patients it is characterized by clinical polymorphism. Read More

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Localized skin inflammation during cutaneous leishmaniasis drives a chronic, systemic IFN-γ signature.

PLoS Negl Trop Dis 2021 Apr 1;15(4):e0009321. Epub 2021 Apr 1.

Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, United States of America.

Cutaneous leishmaniasis is a localized infection controlled by CD4+ T cells that produce IFN-γ within lesions. Phagocytic cells recruited to lesions, such as monocytes, are then exposed to IFN-γ which triggers their ability to kill the intracellular parasites. Consistent with this, transcriptional analysis of patient lesions identified an interferon stimulated gene (ISG) signature. Read More

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A Rare Case of Henoch-Schönlein Purpura and Mycobacterium xenopi Pulmonary Infection.

Cureus 2021 Feb 24;13(2):e13533. Epub 2021 Feb 24.

General Surgery, Lebanese American University-Medical Center, Beirut, LBN.

Henoch-Schönlein purpura (HSP) is a small-vessel vasculitis with cutaneous, articular, gastrointestinal, and renal manifestations. Leukocytoclastic vasculitis and IgA deposits are classically found when involved skin and kidneys are biopsied. The disease's etiology remains unknown, although many bacterial and viral infections have been described as triggering factors. Read More

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February 2021

Experimental Solubility, Thermodynamic/Computational Validations, and GastroPlus-Based In Silico Prediction for Subcutaneous Delivery of Rifampicin.

AAPS PharmSciTech 2021 Mar 24;22(3):116. Epub 2021 Mar 24.

Department of Medical Laboratory Technology, University Polytechnic, Birla Institute of Technology, Mesra, Ranchi, Jharkhand, 835215, India.

We focused to explore a suitable solvent for rifampicin (RIF) recommended for subcutaneous (sub-Q) delivery [ethylene glycol (EG), propylene glycol (PG), tween 20, polyethylene glycol-400 (PEG400), oleic acid (OA), N-methyl-2-pyrrolidone (NMP), cremophor-EL (CEL), ethyl oleate (EO), methanol, and glycerol] followed by computational validations and in-silico prediction using GastroPlus. The experimental solubility was conducted over temperature ranges T = 298.2-318. Read More

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Lupus vulgaris in a mother and child.

BMJ Case Rep 2021 Mar 22;14(3). Epub 2021 Mar 22.

Department of Dermatology, Venereology & Leprosy, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

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A polymorphous cutaneous tuberculosis.

Int J Mycobacteriol 2021 Jan-Mar;10(1):85-88

Department of Dermatology, CHU Ibn Sina, Mohamed V University of Rabat, Rabat, Morocco.

Cutaneous tuberculosis is uncommon, comprising 1%-2% of all extrapulmonary manifestations. It has a wide clinical spectrum. The clinical presentation depends on the route of the infection, the pathogenicity of the bacteria, and the immune status of the host. Read More

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Association between erythema nodosum/ erythema induratum of Bazin and Mycobacterium tuberculosis infection in Koreans.

Indian J Dermatol Venereol Leprol 2021 03 2:1-5. Epub 2021 Mar 2.

Department of Dermatology Kangdong Sacred Heart Hospital, Hallym University College of Medicine, Seoul, Korea.

Background: Erythema nodosum and erythema induratum of Bazin are similar inflammatory diseases of the lower extremities. These are clinically distinguishable entities, though overlap can occur. Both diseases are reported to be related to Mycobacterium tuberculosis infection, but it is very difficult to identify Mycobacterium tuberculosis in skin lesions. Read More

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Reconstructive surgery for sequellae of Mycobacterium ulcerans infection (Buruli ulcer) of the upper limb.

J Plast Surg Hand Surg 2021 Mar 1:1-6. Epub 2021 Mar 1.

Institut de Chirurgie Reconstructive, Abidjan, Côte d'Ivoire.

Introduction: Infection by Mycobacterium ulcerans constitutes a neglected tropical disease whose prevalence seems to have overrun those of cutaneous tuberculosis and leprosy. Its aggressivity depends on a mycolactone toxin. Lesions may involve skin, tendon and bone with a large spectrum of manifestations: non-ulcerative (papules, nodules, plaques), ulcerative and oedematous presentations as well as osteomyelitis with muscular contraction and ankylosis. Read More

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[Disseminated infection caused by the bacillus Calmette-Guérin vaccine and SARS-CoV-2 coinfection in a patient with IL-12 receptor β1 subunit deficiency].

Rev Alerg Mex 2020 Oct-Dec;67(4):401-407

Instituto Mexicano del Seguro Social, Centro Médico Nacional La Raza, Hospital de Especialidades, Ciudad de México, México.

Background: Inborn errors of immunity manifest with a greater susceptibility to infections, autoimmunity, autoinflammatory diseases, allergies, or malignancies. One of these is the mendelian susceptibility to mycobacterial disease. The most frequent etiology is the complete autosomal recessive deficiency of the β1 subunit of the interleukin 12 receptor. Read More

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Gummatous cutaneous tuberculosis associated with the use of infliximab for Crohn's disease.

An Bras Dermatol 2021 Mar-Apr;96(2):228-230. Epub 2021 Jan 31.

Department of Gastroenterology, Faculty of Medicine, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

As the treatment of infectious and parasitic diseases improved, the prevalence of these conditions declined. However, with the expansion of the use of immunobiologicals, opportunistic infections have emerged, especially under atypical presentations. The present study reports the case of a patient treated with infliximab for Crohn's disease, who presented diarrhea, weight loss, abdominal pain, fever, and subcutaneous erythematous nodules that evolved with spontaneous fluctuation and ulceration. Read More

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Case for diagnosis. Cutaneous small vessel vasculitis (anti-proteinase 3 positive), fever, hemoptysis, and lung cavitation in an adult.

An Bras Dermatol 2021 Mar-Apr;96(2):240-242. Epub 2021 Jan 30.

Department of Dermatology and Radiotherapy, Faculty of Medicine, Universidade Estadual Paulista, Botucatu, SP, Brazil. Electronic address:

Small vessel vasculitis with anti-proteinase antibodies 3 is an atypical clinical presentation of tuberculosis. The authors present the case of a 47-year-old male patient, with palpable purpura and palmoplantar hemorrhagic blisters, with subsequent dissemination. He presented severe pulmonary symptoms with cavitation, fever, hemoptysis, and high levels of anti-proteinase 3. Read More

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[Mycobacterium abscessus and Mycobacterium tuberculosis coinfection in a patient with exogenous Cushing syndrome and other comorbilities].

Rev Peru Med Exp Salud Publica 2020 Oct-Dec;37(4):762-766. Epub 2021 Feb 3.

Facultad de Medicina Humana, Universidad Ricardo Palma, Lima, Perú.

Mycobacterium abscessus is a fast-growing non-tuberculous mycobacterium that causes lung, skin, disseminated and other infections, mainly in patients with comorbidities. The diagnosis is based on the identification of the mycobacterium by culture media or molecular tests. Treatment with macrolides and amikacin remains the optimal choice, although it depends on the location and severity of the infection; however, resistance genes have been identified in some subspecies that limit antibiotic efficacy. Read More

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Large neck ulcer in an immunocompetent adult male.

J Postgrad Med 2021 Jan-Mar;67(1):55-56

Department of Dermatology, IMS and SUM Hospital, Bhubaneswar, Odisha, India.

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Cutaneous Coinfection of Cytomegalovirus and Accelerated by Immunosuppression.

Case Rep Pathol 2021 29;2021:8819560. Epub 2021 Jan 29.

Department of Diagnostic Pathology, Shimada Municipal Hospital, Shimada, Shizuoka, Japan.

A mildly diabetic 58-year-old male had traumatic ulceration on the left popliteal fossa, and the lesion progressed to a painful 6 cm deep ulcer. After surgical debridement and skin grafting, ulceration recurred. Pyoderma gangrenosum was clinically diagnosed after the first biopsy, indicating a noninfective ulcer. Read More

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January 2021

A case of broncho-cutaneous fistula secondary to tuberculosis successfully managed with awake veno-venous extracorporeal membrane oxygenation.

Respir Med Case Rep 2021 19;32:101351. Epub 2021 Jan 19.

Department of Critical Care, Guy's and St Thomas' NHS Foundation Trust, Westminster Bridge Road, London, SE1 7EH, UK.

A broncho-cutaneous fistula (BCF) is a communicating tract between the bronchus and the cutaneous surface of the thoracic wall and can be the primary presenting sign of several disease processes. It has been associated with positive pressure ventilation (PPV), post pneumonectomy, thoracostomy tubes, perforating chest trauma, neoplasia and chronic empyema. We report a case of a 45-year-old immunocompetent man presenting with severe hypercapnic respiratory failure secondary to a BCF as a result of tuberculosis (TB)-related empyema necessitans. Read More

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January 2021