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Antibiotics (Basel) 2022 Jun 15;11(6). Epub 2022 Jun 15.

Centre of Excellence for Pharmaceutical Sciences (Pharmacen™), Building G16, Faculty of Health Sciences, North-West University, Potchefstroom 2520, South Africa.

Although chemotherapeutic treatment regimens are currently available, and considerable effort has been lavished on the development of new drugs for the treatment of tuberculosis (TB), the disease remains deeply intractable and widespread. This is due not only to the nature of the life cycle and extraordinarily disseminated habitat of the causative pathogen, principally (), in humans and the multi-drug resistance of to current drugs, but especially also to the difficulty of enabling universal treatment of individuals, immunocompromised or otherwise, in widely differing socio-economic environments. For the purpose of globally eliminating TB by 2035, the World Health Organization (WHO) introduced the "End-TB" initiative by employing interventions focusing on high impact, integrated and patient-centered approaches, such as individualized therapy. Read More

Rev Chilena Infectol 2022 02;39(1):100-102

Hospital Clínico Universidad de Chile, Santiago, Chile.

Erythema induratum of Bazin is a rare form of cutaneous tuberculosis, considered as part of the spectrum of tuberculids or hipersensitivity reactions to Mycobacterium tuberculosis. Treatment with biologic agents is a known risk factor for tuberculosis reactivation, especially in areas of high incidence like Latin America, which is why screening and treatment protocols must be followed before these therapies are initiated. We present a case of erythema induratum of Bazin as a reactivation of latent tuberculosis infection in a patient with rheumatoid arthritis treated with golimumab. Read More

Urol Ann 2022 Apr-Jun;14(2):189-195. Epub 2022 Feb 15.

Department of Internal MedicineDiseases, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia.

Urogenital tuberculosis (UGTB) is almost 8%-15% of the extrapulmonary site of TB of all kinds, and epididymal involvement is rarer, counted only 28% of UGTB. Isolated tuberculous epididymitis (ITE), without the inclusion of prostate or clinical evidence of renal involvement, is an even more rare entity and is challenging to diagnose. However, isolated epididymis TB presented as a huge scrotal abscess with scrotal sack involvement is exceptionally uncommon. Read More

J Invest Dermatol 2022 Jun 1. Epub 2022 Jun 1.

Division of Allergy and Clinical Immunology, Department of Medicine, Groote Schuur Hospital, University of Cape Town, Cape Town, South Africa; Allergy and Immunology Unit, University of Cape Town Lung Institute, Cape Town, South Africa. Electronic address:

Severe cutaneous adverse reactions (SCARs) related to first-line anti-tuberculosis (FTLB) drugs are associated with high mortality and long-term morbidity. Oral sequential drug challenge (SDC), as a form of drug provocation testing, helps salvage therapy by identifying culprit drugs, but is associated with risk and is costly. IFN-γ ELISpot, an adjunctive in vitro diagnostic tool, may help guide risk-stratification approaches. Read More

Int J Dermatol 2022 May 22. Epub 2022 May 22.

Department of Respiratory Medicine, ESIC Medical College & Hospital, Faridabad, India.

Int J Dermatol 2022 May 17. Epub 2022 May 17.

Department of Dermatology & STD, University College of Medical Sciences & GTB Hospital (University of Delhi), Delhi, India.

Background: Tuberculosis (TB) has been one of the most challenging infectious diseases globally. Cutaneous tuberculosis (CTB) accounts for 0.5-2% of extrapulmonary TB and is often missed owing to its varying morphology and paucibacillary nature. Read More

JAAD Case Rep 2022 Jun 1;24:14-17. Epub 2022 Apr 1.

Institute of Dermatology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Policlinico San Matteo, University of Pavia, Pavia, Italy.

Cureus 2022 Apr 6;14(4):e23892. Epub 2022 Apr 6.

Department of Internal Medicine, Bangabandhu Sheikh Mujib Medical University, Dhaka, BGD.

In Bangladesh, tuberculosis and leprosy are endemic mycobacterial diseases; however, co-infection is rarely seen. Our patient had a high-grade fever, symmetrical polyarthritis, polymorphous erythematous lesions, widespread lymphadenopathy, peripheral neuropathy, bilaterally thickened ulnar nerves, and claw hands. A lymph node biopsy revealed tuberculosis having acid-fast bacilli with caseating epithelioid histiocytic granuloma. Read More

Orv Hetil 2022 May 8;163(19):750-757. Epub 2022 May 8.

1 Marosvásárhelyi "George Emil Palade" Orvosi, Gyógyszerészeti, Tudomány- és Technológiai Egyetem, Tüdőgyógyászati Tanszék Marosvásárhely Romania.

Összefoglaló. Bevezetés: Az extrapulmonalis tuberculosis incidenciája növekvő tendenciát mutat annak ellenére, hogy az elmúlt években világszerte csökkent a tuberculosisos esetek száma. Célkitűzés: Az extrapulmonalis tuberculosisra hajlamosító tényezők felmérése és a bakteriológiai és szövettani diagnosztizálási arányok meghatározása az egyes formák esetén. Read More

Int J Gynecol Pathol 2022 Apr 12. Epub 2022 Apr 12.

Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) is a newly described lymphoproliferative lesion characterized by the proliferation of EBV-positive atypical B cells in a variable inflammatory background associated with mucosal or cutaneous ulcers. Commonly involved sites include the oropharyngeal tract, skin, and gastrointestinal tract, with emerging reports describing EBVMCU of genitalia. To date, no lesions have been described of the uterine cervix. Read More

J Gen Intern Med 2022 May 2. Epub 2022 May 2.

Division of Hospital Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

A 23-year-old previously healthy male presented to the hospital with symptoms of heart failure. He was diagnosed with pericarditis and found to have a reduced left ventricular ejection fraction of 25%. He was noted to have mediastinal lymphadenopathy. Read More

Case Rep Dermatol 2022 Jan-Apr;14(1):49-54. Epub 2022 Mar 21.

Department of Clinical Microbiology, Yozgat Bozok University, Yozgat, Turkey.

Cutaneous involvement is a relatively uncommon manifestation of tuberculosis (TB), particularly outside the endemic regions. Cutaneous TB manifests itself in various clinical forms, depending on the host's immune status and mode of transmission. Nonetheless, the same treatment regimen is recommended for every subtype. Read More

RSC Adv 2021 Oct 3;11(56):35472-35488. Epub 2021 Nov 3.

Translational Medicine Center, Beijing Chest Hospital, Capital Medical University Beijing 101149 PR China

Upconversion nanoparticles (UCNPs) are a class of optical nanocrystals doped with lanthanide ions that offer great promise for applications in controllable tumor therapy. In recent years, UCNPs have become an important tool for studying the treatment of various malignant and nonmalignant cutaneous diseases. UCNPs convert near-infrared (NIR) radiation into shorter-wavelength visible and ultraviolet (UV) radiation, which is much better than conventional UV activated tumor therapy as strong UV-light can be damaging to healthy surrounding tissue. Read More

West Afr J Med 2022 Apr;39(4):362-368

Department of Paediatrics and Child Health, UniOsun Teaching Hospital, Osogbo, Osun State, Nigeria.

Background: Studies on mucous infections in HIV infected children are sparse. Cutaneous infections though common, vary in pattern and prevalence over time and location.

Objectives: To provide updates on the prevalence and pattern of muco-cutaneous infections among HIV infected children attending a Nigerian tertiary hospital and identify neglected muco-cutaneous infections. Read More

J Interferon Cytokine Res 2022 04;42(4):180-190

Nanjing Municipal Hospital of Traditional Chinese and Western Medicine Affiliated to Nanjing University of Traditional Chinese Medicine, Jiangsu, China.

We explored the biological functions, signaling pathways, potential inflammation, and immune biomarkers involved in ulcerative cutaneous tuberculosis (UCT). -infected tissues from UCT patients and patients with noncutaneous tuberculous ulcers (NCTUs) were studied using transcriptomic analysis. Functional enrichment determined using the Gene Ontology database and enrichment of signaling pathways was ascertained using the Kyoto Encyclopedia of Genes and Genomes database. Read More

J Postgrad Med 2022 Apr-Jun;68(2):115-116

Department of Dermatology, JSS Medical College and Hospital, JSS Academy of Higher Education and Research, MG Road, Mysore, Karanataka, India.

J Orthop Case Rep 2021 Nov;11(11):79-83

Department of Dermatology, D Y Patil University School of Medicine, Navi Mumbai, Maharashtra, India.

Introduction: Tuberculosis (TB) can present in different ways and should be regarded as one of the possible diagnoses of several bony, cutaneous, and neurological pathologies.

Case Report: We present a case report of a 13-year-old female, who presented with swelling of the left index finger, then diagnosed to have Pulmonary and extra-pulmonary TB (Spina Ventosa, Lichen scrofulosorum, cervical lymphadenitis, mediastinal lymphadenopathy, and a frontal lobe Tuberculoma). We further discuss its features and management. Read More

Dermatol Ther 2022 Apr 7:e15503. Epub 2022 Apr 7.

Department of Dermatology, Faculty of Medicine, Afyonkarahisar Health Sciences University, Afyonkarahisar, Turkey.

BMC Infect Dis 2022 Mar 29;22(1):310. Epub 2022 Mar 29.

Infectious Diseases Department, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.

Background: Actinomycosis is an uncommon endogenous bacterial infection caused by Actinomyces species, characterized by the development of abscesses, tissue fibrosis, and fistulisation. It remains a diagnostic challenge, due to its similarities with diverse aetiologies' presentation, such as neoplasms, tuberculosis, or fungal infections. Actinomyces bovis is a microorganism rarely reported as a cause of human disease. Read More

Pharmacogenomics J 2022 May 22;22(3):147-159. Epub 2022 Mar 22.

Integrative Pharmacogenomics Institute, Universiti Teknologi MARA Cawangan Selangor, Puncak Alam Campus, 42300, Puncak Alam, Selangor, Malaysia.

The major challenges that delay the implementation of pharmacogenomics based clinical practice in the developing countries, primarily the low- and middle-income countries need to be recognized. This review was conducted to systematically review evidence of the cost-effectiveness for the conduct of pharmacogenomics testing in the developing countries. Studies that evaluated the cost-effectiveness of pharmacogenomics testing in the developing countries as defined by the United Nations were included in this study. Read More

SAGE Open Med Case Rep 2022 15;10:2050313X221084839. Epub 2022 Mar 15.

The Royal London Hospital, Barts Health NHS Trust, London, UK.

Paradoxical reaction (also known as Jarisch-Herxheimer reaction) is a self-limited response to endotoxin released from dead bacteria after starting treatment and is characterized by constitutional symptoms such as fever, headache, dizziness and exacerbation of cutaneous lesions. We report a rare case of a 55-year-old gentleman, on peritoneal dialysis, who developed fever, dizziness and cloudy dialysate after starting anti-tuberculous treatment for disseminated tuberculous lymphadenitis. He was started on antibiotics for suspected peritoneal dialysis peritonitis and anti-tuberculosis treatment was continued. Read More

Arerugi 2022 ;71(2):130-134

Department of Respiratory Medicine, Federation of National Public Service and Affiliated Personnel Mutual Aid Associations, Yoshijima Hospital.

A 74-year-old man developed with left pleural effusion and was suspected of benign asbestos pleural effusion and tuberculous pleurisy. Because of elevation of ADA level in the pleural effusion, diagnostic treatment for tuberculous pleurisy by anti-tuberculosis drugs was performed. However, right pleural effusion, cutaneous/mucosal lesions, leukocytopenia, and fever elevation occurred. Read More

Am J Med Sci 2022 06 13;363(6):519-525. Epub 2022 Mar 13.

Department of Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.

Background: Peripheral eosinophilia (eosinophilia) is observed among systemic sclerosis (SSc) patients. The association between eosinophilia and SSc in terms of pathogenesis remains uncertain. We aimed to determine the prevalence of the clinical, serological, and cytokine associations with eosinophilia in SSc patients. Read More

Dtsch Arztebl Int 2021 Dec;118(49):846

Am J Ophthalmol Case Rep 2022 Mar 24;25:101317. Epub 2022 Jan 24.

Oculoplasty, Dhahran Eye Specialist Hospital, Dhahran, Saudi Arabia.

Purpose: We describe a rare case of annular granuloma involving the eyelid of a child, a 6-year-old male, who presented with multiple subcutaneous nodular lesions involving the upper eyelid of the right eye.

Observations: The slit-lamp examination of the eye was normal. Extra-ocular examination showed a lesion on the dorsal aspect of the right foot, which was resistant to treatment with topical corticosteroids. Read More

J Trop Pediatr 2022 02;68(2)

Department of Paediatrics, Vani Vilas Hospital, Bangalore Medical College and Research Institute,Bengaluru 560002, India.

The neonatal skin microbiome consists of all the genomes and genetic products of microorganisms harboring on an infant's skin. Host and the microbiota develop a harmonious environment resulting in symbiosis. Any disruption of this environment could lead to pathological disease. Read More

Minerva Cardiol Angiol 2022 Feb 25. Epub 2022 Feb 25.

DSM Department of Medical Sciences, University of Trieste, Trieste, Italy.

Adamantiades-Behçet Disease (ABD) is a systemic disease with vasculitis, characterised by recurrent oral aphthosis and ocular, cutaneous, articular, vascular, cardiopulmonary manifestations and it is mainly found in the territories of the antique "silk road. ABD pathogenesis remains unknown although genetic, infectious and environmental factors seem to be implicated in the development of the disease, which is considered an auto-inflammatory condition. COVID-19 infection can present some symptoms, in particular at the level of oral and pulmonary mucosa, which require a differential diagnosis with ABD. Read More

Singapore Med J 2022 Feb 24. Epub 2022 Feb 24.

National Skin Centre, Singapore.

Introduction: Ustekinumab is a human monoclonal antibody that binds to the p40 subunit of both interleukin (IL)-12 and IL-23, and it is approved for the treatment of moderate to severe plaque psoriasis. In this study, we assessed the efficacy and safety of patients receiving ustekinumab for psoriasis.

Methods: This retrospective study included all adults with chronic plaque psoriasis who were prescribed ustekinumab in a tertiary dermatologic centre between December 2009 and December 2015. Read More

Photodiagnosis Photodyn Ther 2022 Jun 19;38:102763. Epub 2022 Feb 19.

Department of Dermatology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China; Institute of Dermatology, Jiangxi Academy of Clinical Medical Sciences, Nanchang, Jiangxi, China. Electronic address:

Tuberculosis verrucosa cutis (TBVC) is a rare type of cutaneous tuberculosis, which often occurs in the body with good immunity to tuberculosis bacilli. It usually presents as a hyperkeratotic verrucous plaque with polygonal boarders but can mimic or evolved into other dermatosis such as verruca vulgaris, chromoblastomycosis, hyperkeratotic lupus vulgaris, hypertrophic lichen planus, or squamous cell carcinoma, leading to delayed diagnosis. Here, we reported that a 62-year-old patient diagnosed by TBVC with fester as primary manifestation. Read More

Monaldi Arch Chest Dis 2022 Feb 17. Epub 2022 Feb 17.

Division of Thoracic and Cardiovascular Surgery, University Hospital of Rennes.

The incidence rate of tuberculosis in developed countries is low. The most common presentation of this disease is its pulmonary form but with the increasing use of immunosuppressive drugs, extra-pulmonary tuberculosis is re-emerging. Nevertheless, sternal bone involvement is uncommon. Read More