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Am J Case Rep 2019 Apr 12;20:503-507. Epub 2019 Apr 12.

Department of Dermato-Venerology, Universitas Padjadjaran - Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

BACKGROUND Multifocal tuberculosis (TB) with more than 1 tuberculous osteoarticular lesion is rare. Furthermore, metastatic tuberculous abscess (MTA) is also a very rare manifestation of cutaneous TB in children. A non-specific, often subtle, early clinical presentation in conjunction with a low prevalence rate constitute obstacles for diagnosis. Read More

Scand J Immunol 2019 Apr 8:e12767. Epub 2019 Apr 8.

Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

One of the components of NADPH-oxidase is p47-phox; encoded by NCF1 gene. This study aims to find new genetic changes and clinical features in 38 Iranian patients with autosomal recessive chronic granulomatous disease (AR-CGD) caused by NCF1 gene defect. Patients who had abnormal NBT and DHR-1,2,3 assay with loss of p47-phox in western blotting were included in this study. Read More

Clin Nucl Med 2019 Mar 29. Epub 2019 Mar 29.

From the Department of Nuclear Medicine and PET, Mahatma Gandhi Medical College & Hospital, Jaipur, Rajasthan, India.

The present article presented a 47-year-old woman with areas of nodular swelling and discoloration involving bilateral lower limbs since 12 months. Biopsy from skin lesions revealed erythema nodosum. As erythema nodosum can be secondary to multiple etiologies, whole-body F-FDG PET/CT was performed to assess the disease distribution and guide the site of biopsy. Read More

Malays J Med Sci 2018 Sep 30;25(5):103-114. Epub 2018 Oct 30.

Respiratory Department, Hospital Pulau Pinang, Jalan Residensi, 10990 Georgetown, Pulau Pinang, Malaysia.

Background: The use of multi-drug regimens in tuberculosis (TB) treatment has been associated with undesirable adverse drug reactions (ADRs). This study aims to assess the incidence and impact of ADRs on TB treatment in Hospital Pulau Pinang.

Methods: This cross-sectional study was conducted via retrospective review of outpatients' medical records. Read More

J Fungi (Basel) 2019 Mar 21;5(1). Epub 2019 Mar 21.

Department of Medical Microbiology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India.

Mucormycosis is an angio-invasive fungal infection, associated with high morbidity and mortality. A change in the epidemiology of mucormycosis has been observed in recent years with the rise in incidence, new causative agents and susceptible population. The rise has been perceived globally, but it is very high in the Asian continent. Read More

Cutis 2018 Feb;102(2):E32-E35

Dermatology Associates of South Jersey, Mount Laurel, New Jersey, USA.

Cutaneous gummatous tuberculosis (TB) is an uncommon subtype of cutaneous TB that can be seen in notably immunocompromised individuals. We report a case of cutaneous gummatous TB in an immunosuppressed kidney transplant patient. A 60-year-old Cambodian woman presented with fever attributed to recurrent pyelonephritis while on immunosuppressive medications 7 months after kidney transplant. Read More

J Pak Med Assoc 2019 Mar;69(3):412-414

Philadelphia University, Amman, Jordan.

The review aims to examine the emergence and reemergence of infectious diseases in Jordan, in parallel with the Syrian refugee crisis. Qualitative approach has been adopted for systematically examining the outcomes of Syrian Crisis, which resulted with emerging and re-emerging infectious diseases. It has adhered that infectious diseases; including measles, tuberculosis, and Cutaneous Leishmaniasis, have hazardous effects on Syrian refugees along with alarming threats to local population in Jordan. Read More

Korean J Intern Med 2019 Mar 19. Epub 2019 Mar 19.

Department of Internal Medicine, Chonnam National University Hospital, Gwangju, Korea.

Background/aims: Peripheral eosinophilia during tuberculosis (TB) treatment is common, but has not been fully evaluated. The aim of this study was to determine the prevalence and clinical significance of peripheral blood eosinophilia in patients undergoing anti-TB treatment.

Methods: We retrospectively reviewed the clinical and laboratory data of patients who received anti-TB treatment and had peripheral blood eosinophilia (> 5% of the total white blood cell count) at the Chonnam National University Hospital between January 2010 and December 2014. Read More

Theranostics 2019 25;9(4):945-960. Epub 2019 Jan 25.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Renal Cancer and Melanoma, Peking University Cancer Hospital and Institute, Beijing 100142, China.

Mucosal melanoma (MM) is the second most common melanoma subtype in Asian populations. Deregulation of microRNAs (miRNAs) has been extensively investigated in various cancers, including cutaneous melanoma. However, the roles of miRNAs in MM are unclear. Read More

Am J Trop Med Hyg 2018 Dec;99(6):1360-1361

Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Perú.

BMJ Case Rep 2019 Feb 21;12(2). Epub 2019 Feb 21.

Medical Oncology, Hospital Distrital De Santarem Epe, Santarem, Santarém, Portugal.

The authors present the case of a woman in the seventh decade of life with medical history of: left nephrectomy for renal tuberculosis and non-Hodgkin's lymphoma treated with chemotherapy (QT) and radiotherapy. She presented with a 2-month history of non-tender, left inguinal lymph node enlargement. Positron Emission Tomography (PET)CT -scanshowed hypermetabolic inguinal and retroperitoneal lymphadenopathies, no primary tumour. Read More

Emerg Infect Dis 2019 Mar;25(3):600-601

Buruli ulcer is a necrotizing skin disease caused by Mycobacterium ulcerans and is usually associated with tropical climates and exposure to slow-moving or stagnant water. We report a case of Buruli ulcer that may have originated in an urban semiarid area of Senegal. Read More

Cutis 2019 Jan;103(1):38-42

Department of Dermatology, Massachusetts General Hospital, Boston, USA.

Idiopathic granulomatous mastitis (IGM) is a rare, poorly understood condition that presents as inflammatory nodules of the breast. It is often initially misdiagnosed as furunculosis or cellulitis. Despite the painful, scarring, and debilitating nature of the disease, patients often have a delay in accurate diagnosis and treatment. Read More

Infect Genet Evol 2019 Jun 7;70:27-35. Epub 2019 Feb 7.

Immunogenetics Research Center, Department of Medical Nanotechnology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

There is a need for new, effective, and less expensive and toxic treatment for Leishmaniasis. It seems that the use of a suitable adjuvant and a delivery system is effective in inducing immune reactions for protection. Liposomes can be applied as immunoadjuvants to trigger immune reactions to different antigens. Read More

An Bras Dermatol 2019 Jan-Feb;94(1):102-104

Discipline of Dermatology, Medicine Course, Universidade Federal de São João del-Rei, Divinópolis (MG), Brazil.

Cutaneous tuberculosis is a rare form of extrapulmonary tuberculosis, comprising 1-2% of cases. Caused by Mycobacterium tuberculosis or related strains, it presents a wide range of clinical manifestations, mimicking other chronic dermatoses and leading to delayed diagnosis. A case of scrofuloderma is reported, whose diagnosis and treatment were only made six years after onset of the disease. Read More

BMC Infect Dis 2019 Jan 29;19(1):97. Epub 2019 Jan 29.

Department of Medicine, University of Calgary, Alberta, Canada.

Background: Erythema induratum of Bazin (EIB) - nodular vasculitis associated with Mycobacterium tuberculosis (TB) - and Tuberculosis-Associated Ocular Inflammation (TB-AOI) represent uncommon manifestations of TB. There is limited data and a lack of diagnostic and treatment standards for these conditions.

Methods: Eleven-year retrospective review of EIB and TB-AOI cases managed in a provincial TB program with prospective phone-based follow-up of anti-tubercular therapy (ATT) recipients. Read More

N Engl J Med 2019 Jan;380(3):275-283

From the Departments of Medicine (S.T.C., E.T.R.), Dermatology (S.T.C.), Radiology (A.M.C.), and Pathology (R.K.F.), Massachusetts General Hospital, the Departments of Dermatology (S.T.C.), Medicine (E.T.R.), Radiology (A.M.C.), and Pathology (R.K.F.), Harvard Medical School, and the Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health (E.T.R.) - all in Boston.

Int J Dermatol 2019 Jan 8. Epub 2019 Jan 8.

Department of Dermatology and Cutaneous Surgery, Miller School of Medicine, University of Miami, Miami, FL, USA.

AAPS PharmSciTech 2019 Jan 2;20(1):33. Epub 2019 Jan 2.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.

Vesicles are widely investigated as carrier systems for active pharmaceutical ingredients (APIs). For topical delivery, they are especially effective since they create a "depot-effect" thereby concentrating the APIs in the skin. Artemisone, clofazimine and decoquinate were selected as a combination therapy for the topical treatment of cutaneous tuberculosis. Read More

J Am Coll Clin Wound Spec 2017 21;9(1-3):35-38. Epub 2018 Jun 21.

Department of Medicine, Hospital Sultan Abdul Halim, 08000 Sungai Petani, Kedah, Malaysia.

A 72-year-old man presented with a chronic scaly verrucous plaque over his right knee for nine months. The lesion was preceded by a well healed scar sustained five years back from a road traffic accident. He was given multiple courses of systemic antibiotic and antifungal medications but to no avail. Read More

Int J Dermatol 2018 Dec 25. Epub 2018 Dec 25.

Department of Dermatology, Changi General Hospital, Singapore, Singapore.

Background: Unfamiliarity with the presentation, diagnostic process, and treatment of cutaneous non-tuberculous mycobacterium (NTM) infection leads to poorer outcomes. We describe our experience with managing cutaneous NTM infection in a regional hospital in Singapore from 2005 to 2014.

Methods: Adult patients with cutaneous NTM infections were identified through positive skin tissue cultures in this retrospective case series. Read More

Med Mal Infect 2018 Dec 21. Epub 2018 Dec 21.

Groupe hospitalier Pitié-Salpêtrière Charles-Foix, Assistance publique-Hôpitaux de Paris, 73013 Paris, France. Electronic address:

Background: Diphtheria is re-emerging in Europe. A total of 36 cases were reported in Europe in 2015 versus 53 cases between 2000 and 2009.

Patients: We report two cases of Corynebacterium diphtheriae infection in a French hospital in 2016: a cutaneous infection with negative toxin testing in a French traveller, and a respiratory diphtheria carriage with positive toxin testing in an Afghan refugee diagnosed with pulmonary tuberculosis. Read More

J Am Acad Dermatol 2019 Apr 21;80(4):1162-1164. Epub 2018 Dec 21.

Corporal Michael J. Crescenz Veterans Affairs Medical Center, Philadelphia, Pennsylvania; Department of Dermatology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania. Electronic address:

Diagn Cytopathol 2019 May 24;47(5):458-468. Epub 2018 Dec 24.

Department of Dermatology and STD, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India.

Objectives: The diagnosis of cutaneous tuberculosis is challenging due to its diverse clinical manifestations, paucibacillary state and lack of proper diagnostic tests. Clinico-pathological correlation is still frequently used for diagnosis. There is paucity of literature on cytomorphological features. Read More

BMJ Case Rep 2018 Dec 19;11(1). Epub 2018 Dec 19.

General Surgery, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, Karnataka, India.

Tuberculosis (TB) is a global disease and if not adequately treated can lead to morbidity and mortality. Though genitourinary TB is common and only next to pulmonary TB, cutaneous 'ulcerative' tuberculosis of the scrotum is not reported so far in the literature. We present a 32-year-old man with a non-healing scrotal ulcer and underwent excision. Read More

J Atheroscler Thromb 2019 Feb 15;26(2):121-127. Epub 2018 Dec 15.

Diabetes and Lifestyle-related Disease Center, Fukujuji Hospital, Japan Anti-Tuberculosis Association.

Pharmacological treatments to decrease low-density lipoprotein (LDL) cholesterol (LDL-C) have limited effects on patients with homozygous familial hypercholesterolemia (HoFH). Since LDL receptors are located mainly in the liver, liver transplantation is considered to be the only way to correct the hepatic cholesterol metabolism abnormalities in HoFH. Liver transplantations, including those combined with heart transplantation, for HoFH have been increasing since 1984, making this a globally established therapeutic option for HoFH. Read More

J Med Case Rep 2018 Dec 17;12(1):371. Epub 2018 Dec 17.

Department of Pediatrics and Child Health, College of Medicine and Health Sciences, Hawassa University, Hawassa, Ethiopia.

Background: Cutaneous tuberculosis represents only 1-2% of extrapulmonary forms of tuberculosis. Scrofuloderma is an endogenous form of cutaneous tuberculosis and can present as isolated or coexist with pulmonary and disseminated forms of tuberculosis. Pathologically confirmed scrofuloderma coexisting with disseminated tuberculosis with a good treatment response is presented and discussed. Read More

JAAD Case Rep 2019 Jan 27;5(1):1-4. Epub 2018 Nov 27.

Dermatology Department, University Hospital of Bordeaux, Bordeaux, France.

Am J Dermatopathol 2018 Nov 27. Epub 2018 Nov 27.

Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional SXXI, IMSS, Mexico City, México.

The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tuberculosis. Read More

Lancet Infect Dis 2018 Dec;18(12):1410

Department of Medicine, University of Toledo, Toledo, OH, USA.

An Bras Dermatol 2018 Nov/Dec;93(6):887-889

Department of Dermatology and Venereology, Hospital Santo António dos Capuchos, Centro Hospitalar de Lisboa Central, Lisbon, Portugal.

Nodular vasculitis is an uncommon type of panniculitis. It was firstly associated to the infection by Mycobacterium tuberculosis and named erythema induratum of Bazin, however nowadays it has been associated with several other underlying disorders and it is better described as nodular vasculitis. Concerning its relationship with malignant conditions, there is only one reported case, in association with metastatic colon adenocarcinoma. Read More

Allergy Asthma Immunol Res 2019 Jan;11(1):90-103

Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.

Purpose: Although there have been reported cases of drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome caused by antituberculosis drugs, there has been no research to examine its prevalence. This study assessed the prevalence and clinical characteristics of DRESS syndrome caused by antituberculosis drugs.

Methods: The electronic medical records of a cohort consisting of adult patients diagnosed with tuberculosis between July 2006 and June 2010 were reviewed and retrospectively inspected. Read More

Clin Microbiol Rev 2018 01 14;32(1). Epub 2018 Nov 14.

Servicio de Dermatología y Departamento de Micología, Hospital General de México, Mexico City, Mexico.

Humans encounter mycobacterial species due to their ubiquity in different environmental niches. In many individuals, pathogenic mycobacterial species may breach our first-line barrier defenses of the innate immune system and modulate the activation of phagocytes to cause disease of the respiratory tract or the skin and soft tissues, sometimes resulting in disseminated infection. Cutaneous mycobacterial infections may cause a wide range of clinical manifestations, which are divided into four main disease categories: (i) cutaneous manifestations of infection, (ii) Buruli ulcer caused by and other related slowly growing mycobacteria, (iii) leprosy caused by and , and (iv) cutaneous infections caused by rapidly growing mycobacteria. Read More

Skinmed 2018 9;16(5):301-303. Epub 2018 Nov 9.

Dermato-Venereology (Skin/VD) Center, Sehgal Nursing Home, Panchwati, Delhi, India;

The clinical diagnosis of cutaneous tuberculosis (CT) was based on criteria of reinfection and reactivation. Laboratory tests are mandatory but have limitations, thus demanding continuous innovation. In our study, we took punch biopsies from lesions on 48 patients. Read More

Eur J Dermatol 2018 Aug;28(4):569-570

Department of Dermatology and Venerology, Peking University First Hospital, Beijing, 100034, China.

Int J Dermatol 2019 Feb 1;58(2):e29-e30. Epub 2018 Nov 1.

Department of Dermatology and Sexually Transmitted Diseases, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Saudi J Kidney Dis Transpl 2018 Sep-Oct;29(5):1199-1202

Department of Dermatology, Jaslok Hospital and Research Center, Mumbai, Maharashtra, India.

Zinc deficiency is an uncommon condition, known to occur in two forms: inherited type, known as Acrodermatitis enteropathies and the acquired type. Cutaneous clinical manifestations observed include characteristic dermatitis on acral, periorificial, and anogenital areas through an unknown mechanism. The patient had a combination of causes which lead to a state of zinc deficiency. Read More

Iran J Kidney Dis 2018 Oct;12(5):312-314

Infectious Diseases and Tropical Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Mycobacterium haemophilum is a fastidious nontuberculosis Mycobacterium that must be considered in the differential diagnosis of infections in immunocompromised patients. Mycobacterium haemophilum typically is a pathogen of the cutaneous or subcutaneous tissue and also presents as septic arthritis, osteomyelitis, pulmonary disease, and lymphadenitis. We report a 32-year-old man with past medical history of kidney transplantation, endocarditis, gastrointestinal bleeding, and hypertension, complaining of multiple painful nodular lesions since 3 months earlier. Read More

J Clin Aesthet Dermatol 2018 Sep 1;11(9):42-46. Epub 2018 Sep 1.

Drs. Kaur, Kucheria, and Thami are with the Department of Dermatology, Venereology, and Leprosy and the Government Medical College and Hospital in Chandigarh, India.

Extrapulmonary tuberculosis is uncommon and has an insidious onset with slow evolution and a paucibacillary nature. Here, we present a case of disseminated tuberculosis in an adult immunocompetent man presenting with morphologically different types of cutaneous lesions (i.e. Read More

J Inflamm Res 2018 28;11:377-388. Epub 2018 Sep 28.

Department of Dermatology, Safdarjung Hospital, New Delhi, India,

Background: The clinical forms of cutaneous tuberculosis (CTB) consist of a spectrum that reflects the host's immune response to ; it provides an ideal model to study the immunological dysregulation in humans. IL-17 plays an important role in initial immune response and is involved in both immune-mediated protection and pathology during infection. TGF-β producing regulatory T-cells (Tregs) are high in leprosy patients and responsible for immune suppression. Read More

BMC Clin Pathol 2018 1;18. Epub 2018 Oct 1.

3Department of Nephrology and Renal Transplantation Medicine, Grande International Hospital, Kathmandu, Nepal.

Background: The cutaneous nocardiosis remains a diagnostic challenge: similar clinical presentations as of cutaneous diseases with different etiology-and the inherent difficulty in cultivating the pathogen.

Case Presentation: Herein, we describe a case of primary cutaneous nocardiosis in a renal transplant recipient; treated with anti-tubercular drugs due to misdiagnosis of cutaneous tuberculosis. On clinical examinations, a few red erythematous papules with erosions and crusting seen, over prior surgery scar of renal transplant. Read More

Dermatology 2018 2;234(5-6):220-225. Epub 2018 Oct 2.

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.

Background: Micropapular cutaneous sarcoidosis (MPCS) is a rare variant of sarcoidosis. Herein we review the literature and include a recent case of MPCS discussing pathogenesis, diagnosis, treatment, and prognosis.

Method: A review was conducted using the terms "micropapular sarcoidosis" and "micropapular sarcoid. Read More

World J Pediatr 2018 Dec 29;14(6):548-554. Epub 2018 Sep 29.

Department of Pediatrics and Department of Dermatology and Skin Sciences, University of British Columbia, Vancouver, BC, Canada.

Background: Erythema nodosum can be associated with a number of systemic diseases. There is, however, a paucity of information in the pediatric literature on this condition. The purpose of this article is to familiarize pediatricians with the evaluation, diagnosis, and treatment of erythema nodosum. Read More

Urol J 2018 09 22. Epub 2018 Sep 22.

Faculty of Medicine,Mashhad University of Medical Sciences, Mashhad, Iran.

The presented case concerns a 53-year-old male who had been treated for nonspecific cutaneous lesions for two months without any improvement. After developing an erosive penile ulcer he was referred to our department. Investigation for sexually transmitted diseases and Mycobacterium tuberculosis ended with negative results. Read More

Dtsch Med Wochenschr 2018 09 19;143(19):1361-1362. Epub 2018 Sep 19.

HEIDELBERGHISTO, Heidelberg.

BMC Res Notes 2018 Sep 14;11(1):667. Epub 2018 Sep 14.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.

Objective: The purpose of our study was to describe the histological diagnosed of the Basidiobolomycosis cases from 1990 to 2017 (28 years) in the only Pathology Anatomy Laboratory in Togo.

Results: A total of 12 cases of suspected Basidiobolomycosis have been identified. The sex ratio (M/F) was 2. Read More

Semin Cutan Med Surg 2018 Sep;37(3):134-142

Kimberly and Eric J. Waldman Department of Dermatology, Icahn School of Medicine, New York, New York, USA.

Tumor necrosis factor (TNF)-α has been identified as a key cytokine mediating cutaneous inflammation in the pathogenesis of psoriasis. The TNF inhibitors (TNFi's) infliximab, adalimumab, and etanercept are efficacious, Food and Drug Administration-approved medications for the treatment of moderate-to-severe plaque psoriasis. Each drug has a unique pharmacological profile that can have therapeutic implications when choosing a particular TNFi for a patient. Read More

J Allergy Clin Immunol Pract 2019 Mar 8;7(3):969-974. Epub 2018 Sep 8.

Department of Pulmonary Medicine, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India. Electronic address:

Background: Chronic pulmonary aspergillosis (CPA) and allergic bronchopulmonary aspergillosis (ABPA) are presumed to represent 2 distinct manifestations of Aspergillus species in the lung.

Objective: To investigate any possible overlap of the immunological tests used for diagnosing ABPA in proven cases of CPA.

Methods: In consecutive subjects with CPA, we calculated the proportion of subjects who tested positive for all the immunological investigations used to diagnose ABPA (Aspergillus fumigatus specific IgE >0. Read More

Int J Syst Evol Microbiol 2018 Nov 11;68(11):3557-3562. Epub 2018 Sep 11.

3​Emerging Bacterial Pathogens Unit, IRCCS San Raffaele Scientific Institute, Milano, Italy.

Two mycobacterial strains with close similarity to the Mycobacterium tuberculosis complex (MTBC) were isolated from cutaneous lesions of patients in the USA and Italy. At the phenotypic level, similarities to the MTBC included slow growth rate, rough morphotype of the unpigmented colonies and nearly identical high-performance liquid chromatography profiles of mycolic acids. In contrast to the MTBC, the strains were niacin- and nitrate-negative, and catalase-positive both at 68 °C and in semi-quantitative tests. Read More

Am J Med 2019 Jan 7;132(1):52-54. Epub 2018 Sep 7.

Yale University School of Medicine, New Haven, Conn; VA Connecticut Healthcare System, West Haven. Electronic address: