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J Am Acad Dermatol 2021 Jun 8. Epub 2021 Jun 8.

Department of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231. Electronic address:

Am J Hematol 2021 Jun 10. Epub 2021 Jun 10.

Huntington Memorial Hospital, United States.

Introduction: Aggressive T-cell Lymphomas continue to have a poor prognosis. There are over 27 different subtypes of peripheral T-cell lymphoma (PTCL) and we are now beginning to understand the differences between the various subtypes beyond histologic variations.

Molecular Pathogenesis Of Various Subtypes Of Ptcl: Gene expression profiling (GEP) can help in diagnosis and prognostication of various subtypes including PTCL-nos and anaplastic large cell lymphoma (ALCL). Read More

Hematol Oncol 2021 Jun;39 Suppl 1:46-51

Department of Dermatology, Venereology and Allergology, University Medical Center Göttingen, Göttingen, Germany.

Cutaneous T-cell lymphomas (CTCL) represent the majority of primary cutaneous lymphomas (CL). Mycosis fungoides (MF) and cutaneous CD30+ lymphoproliferative disorders account for 80% of all CTCL. CTCL show overlapping histological features. Read More

Adv Pharmacol 2021 4;91:141-183. Epub 2021 Mar 4.

Department of Pharmacology & Toxicology, Michigan State University, East Lansing, MI, United States. Electronic address:

The discovery of nuclear receptors, particularly retinoid X receptors (RXR), and their involvement in numerous pathways related to development sparked interest in their immunomodulatory properties. Genetic models using deletion or overexpression of RXR and the subsequent development of several small molecules that are agonists or antagonists of this receptor support a promising therapeutic role for these receptors in immunology. Bexarotene was approved in 1999 for the treatment of cutaneous T cell lymphoma. Read More

Cureus 2021 May 2;13(5):e14808. Epub 2021 May 2.

Division of Hematology and Oncology, University of Florida, Gainesville, USA.

Herein, we present the case of a 63-year-old female with a history of Behçet's disease managed with long-term prednisone and azathioprine who initially presented for symptomatic anemia, which progressed to pancytopenia with neutropenic fever. Initial workup ruled out infectious etiologies but was indeterminate for immune-mediated or neoplastic causes. Bone marrow biopsy demonstrated a CD8+ gamma-delta T-cell neoplasm; however, imaging and skin biopsy pathology did not support hepatosplenic or cutaneous lymphoma involvement. Read More

Front Immunol 2021 19;12:687673. Epub 2021 May 19.

Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States.

Immunotherapies are revolutionizing cancer treatment by boosting the natural ability of the immune system. In addition to antibodies against traditional checkpoint molecules or their ligands (i.e. Read More

Dermatology 2021 Jun 4:1-11. Epub 2021 Jun 4.

Department of Dermatology, Rabin Medical Center, Beilinson Hospital, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Background: Mycosis fungoides (MF) is the most common form of cutaneous T-cell lymphoma. Patients can be treated using chlormethine gel, a skin-directed therapy developed and approved for MF. In the randomized, controlled 201 trial, chlormethine gel was found to be noninferior to equal-strength chlormethine ointment. Read More

J Invest Dermatol 2021 Jun 2. Epub 2021 Jun 2.

Institute for Cancer Genetics, Columbia University, New York, NY, USA; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA. Electronic address:

Sézary Syndrome (SS) is an aggressive and disseminated form of Cutaneous T-cell lymphoma (CTCL) associated with dismal prognosis in which the histone deacetylase inhibitor romidepsin, has shown remarkable activity as a single agent. However, clinical responses to romidepsin are typically transient, highlighting the need for more effective therapies. Here, we show synergistic anti-lymphoma effects of romidepsin in combination with mechlorethamine, an alkylating agent, in CTCL cell lines and primary samples with strong antitumor effects in an in vivo model of SS. Read More

Clin Exp Dermatol 2021 Jun 3. Epub 2021 Jun 3.

Houston Methodist Cancer Center, Houston, TX, USA.

Introduction: Primary cutaneous anaplastic large-cell lymphoma (PC-ALCL) is a rare T-cell lymphoma. A prior analysis of the Surveillance, Epidemiology, and End Results (SEER) database reported only 157 cases of primary localized PCLPD (PC-ALCL and LyP). from 1973 to 2004. Read More

Zhonghua Bing Li Xue Za Zhi 2021 Jun;50(6):673-675

Department of Pathology, Guizhou Medical University, Guiyang 550004, China.

Zhonghua Bing Li Xue Za Zhi 2021 Jun;50(6):609-614

Department of Pathology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.

To investigate the clinicopathological features and differential diagnosis of primary cutaneous nasal extranodal NK/T cell lymphoma (pcENKTCL-NT). Fifteen cases of pcENKTCL-NT were collected at the First Affiliated Hospital of Zhengzhou University from January 2016 to December 2019. The clinical characteristics, morphological features, immunophenotypes, and results of in situ hybridization and gene detection were analyzed. Read More

J Pers Med 2021 May 27;11(6). Epub 2021 May 27.

Peter MacCallum Cancer Centre, Melbourne, VIC 3000, Australia.

The T-cell lymphomas are a rare group of Non-Hodgkin's lymphomas derived from mature T-lymphocytes. They are divided broadly into the Peripheral T-cell lymphomas and the Cutaneous T-cell lymphomas. Clinical outcomes vary widely but are generally unsatisfactory with current treatments. Read More

Medicina (Kaunas) 2021 May 15;57(5). Epub 2021 May 15.

Research Center for the Morphologic Study of the Skin, Department of Dermatology and Venereology, "Victor Babeș" University of Medicine and Pharmacy, Eftimie Murgu Sq. No. 2, 300041 Timișoara, Romania.

Mycosis fungoides (MF) and large plaque parapsoriasis (LPP) evolution provide intriguing data and are the cause of numerous debates. The diagnosis of MF and LPP is associated with confusion and imprecise definition. Copy number alterations (CNAs) may play an essential role in the genesis of cancer out of genes expression dysregulation. Read More

J Dermatol 2021 Jun 1. Epub 2021 Jun 1.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Comprehensive studies of primary cutaneous extranodal natural killer/T-cell lymphoma (PCENKTL) are scarce. The objectives of this study are to describe PCENKTL in terms of its clinical features, histopathology, immunophenotypes, and prognosis, and to analyze factors affecting patient survival outcomes. We searched four databases and include studies with extractable data. Read More

J Eur Acad Dermatol Venereol 2021 Jun 1. Epub 2021 Jun 1.

Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria.

Diagnosis of mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma (CTCL), can be challenging given the overlapping clinical and pathologic features with various other conditions. High-throughput TCR sequencing (HT-TCRseq) has an outstanding capacity to facilitate diagnosis of CTCL , identify aggressive forms of MF in early-stage , and associate burden of malignant cells with response to PUVA treatment . Read More

Med Clin North Am 2021 Jul;105(4):737-755

Department of Dermatology, VU Cutaneous Lymphoma Clinic, Vanderbilt University Medical Center, Vanderbilt Dermatology, One Hundred Oaks, 719 Thompson Lane, Suite 26300, Nashville, TN 37204-3609, USA. Electronic address:

The cutaneous lymphomas are malignancies of T-cell and B-cell lymphocytes in which the skin is the primary organ of involvement. The cutaneous T-cell lymphomas include variants that can mimic the presentation of common skin diseases or arthropod bites. Mycosis fungoides, the most common cutaneous T-cell lymphoma, usually presents as fixed asymptomatic patches or plaques in sun-protected areas. Read More

Front Oncol 2021 13;11:688755. Epub 2021 May 13.

The Anticancer Fund, Strombeek-Bever, Belgium.

Vaccines used to prevent infections have long been known to stimulate immune responses to cancer as illustrated by the approval of the Bacillus Calmette-Guérin (BCG) vaccine to treat bladder cancer since the 1970s. The recent approval of immunotherapies has rejuvenated this research area with reports of anti-tumor responses with existing infectious diseases vaccines used as such, either alone or in combination with immune checkpoint inhibitors. Here, we have reviewed and summarized research activities using approved vaccines to treat cancer. Read More

An Bras Dermatol 2021 May 27. Epub 2021 May 27.

Hematology Clinic Division, Faculty of Medicine, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brazil.

Cutaneous T-cell lymphomas are a heterogeneous group of lymphoproliferative disorders, characterized by infiltration of the skin by mature malignant T cells. Mycosis fungoides is the most common form of cutaneous T-cell lymphoma, accounting for more than 60% of cases. Mycosis fungoides in the early-stage is generally an indolent disease, progressing slowly from some patches or plaques to more widespread skin involvement. Read More

Br J Dermatol 2021 May 30. Epub 2021 May 30.

Laboratory for Molecular Dermatology, Felsenstein Medical Research Center, Petach Tikva, 4941492, Israel.

Background: Literature regarding exosomes as mediators in intercellular communication to promote progression in mycosis fungoides (MF) is lacking.

Objective: To characterize MF-derived exosomes and their involvement in the disease.

Methods: Exosomes were isolated by ultracentrifugation from cutaneous T-cell lymphoma (CTCL) cell lines, plasma of MF patients, and controls (healthy individuals), and confirmed by electron microscopy, NanoSight, and CD81 staining. Read More

Histopathology 2021 May 29. Epub 2021 May 29.

Department of Pathology and Laboratory Medicine, The University of Calgary, Calgary, Alberta, Canada.

Primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma (PCAECyTCL), historically described as Berti's lymphoma, is a rare entity with a rapid and usually fatal clinical course. While the clinicopathologic features are typically characteristic in their aggressiveness, this entity shares some histomorphologic overlap with lymphomatoid papulosis (LyP) type D, a more indolent disease. We report an intriguing case of presumed transformation of an initially indolent LyP into an aggressive PCAECyTCL. Read More

Indian J Nucl Med 2021 Jan-Mar;36(1):103-104. Epub 2021 Mar 4.

Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.

Diffuse extranodal cutaneous lymphomatous involvement is a unique presentation in a case of adult T-cell lymphoma. We present the case of a 26-year-old female who presented with erythematous rashes with subsequent evaluation with 18F fluorodeoxyglucose positron-emission tomography-computed tomography showing enlarged inguinal and axillary lymph nodes, and biopsy findings from the inguinal lymph nodes were suggestive of adult T-cell lymphoma. Read More

BMC Cancer 2021 May 26;21(1):618. Epub 2021 May 26.

Department of Biotherapy, State Key Laboratory of Biotherapy, West China Hospital, Cancer Center, Sichuan University, No. 37 Guo Xue Alley, Chengdu, 610041, Sichuan, China.

Background: CC chemokine receptor 4 (CCR4), the receptor for CCL22 and CCL17, is expressed on the surface of effector Tregs that have the highest suppressive effects on antitumor immune response. CCR4 is also widely expressed on the surface of tumor cells from patients with adult T-cell leukemia/lymphoma (ATL), peripheral T-cell lymphoma (PTCL) and cutaneous T-cell lymphoma (CTCL). Mogamulizumab is a humanized, IgG1 kappa monoclonal antibody that is directed against CCR4. Read More

JAMA Dermatol 2021 May 26. Epub 2021 May 26.

Department of Dermatology, University of Pennsylvania Perelman School of Medicine, Philadelphia.

Importance: Immunodeficiency-related, vaccine-derived rubella virus (RuV) as an antigenic trigger of cutaneous and visceral granulomas is a rare, recently described phenomenon in children and young adults treated with immunosuppressant agents.

Objective: To perform a comprehensive clinical, histologic, immunologic, molecular, and genomic evaluation to elucidate the potential cause of an adult patient's atypical cutaneous granulomas.

Design, Setting, And Participants: A prospective evaluation of skin biopsies, nasopharyngeal swabs, and serum samples submitted to the Centers for Disease Control and Prevention was conducted to assess for RuV using real-time reverse-transcriptase polymerase chain reaction (RT-PCR) and viral genomic sequencing. Read More

Ital J Dermatol Venerol 2021 May 26. Epub 2021 May 26.

UOC Dermatologia, Dipartimento di Medicina Interna Fondazione IRCCS Ca' Granda - Ospedale Maggiore Policlinico, Milan, Italy.

Mycosis fungoides (MF) is a rare neoplasm representing the most frequent form of primary cutaneous T-cell lymphoma (CTCL). Diagnosis of MF is generally complex, often requiring integration of clinical, histological, immunophenotypic and molecular data. Currently, there are no epidemiological data supported by registries or local studies on MF in Italy. Read More

Vet Dermatol 2021 May 25. Epub 2021 May 25.

QML Pathology, 11 Riverview Place, Murrarie, QLD, 4172, Australia.

Canine cutaneous epitheliotropic T-cell lymphoma (CETL) is associated with a poor prognosis and without consistently beneficial treatment options. This case report describes a 9-year-old Staffordshire bull terrier with CETL treated with oclacitinib (0.7 mg/kg twice daily), resulting in partial remission that was maintained for three months. Read More

Australas J Dermatol 2021 May 24. Epub 2021 May 24.

School of Medicine, University of Western Australia, Nedlands, Western Australia, Australia.

We report the case of a 59-year-old woman with stage IV erythrodermic mycosis fungoides (MF) and large cell transformation who, despite failing multiple previous treatments, achieved complete remission through a combination of pralatrexate and romidepsin followed by allogeneic hematopoietic stem cell transplantation (alloSCT). Further studies are needed in focussing on this combined regimen in treating cutaneous T-cell lymphoma (CTCL) and its efficacy as a bridging regimen in facilitating successful alloSCT. Read More

Biochem Biophys Rep 2021 Jul 4;26:101007. Epub 2021 May 4.

Department of Dermatology, Leiden University Medical Center, the Netherlands.

Aim: Recent studies suggested a role for IL31 in the pathogenesis of pruritus and disease severity in patients with cutaneous T cell lymphomas (CTCL). However, discrepant results were reported for IL31 serum levels, transcriptional expression levels or immunohistochemistry studies and its relation to pruritus intensity and/or disease severity in CTCL. Most studies did not distinguish between different CTCL variants. Read More

Biochem Biophys Rep 2021 Jul 8;26:101005. Epub 2021 May 8.

Department of Dermatology, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400, Copenhagen, Denmark.

Background: Immortalized mammalian cell lines are a valuable research tool, though they represent a highly simplified model. Due to accumulated mutations they may not reflect characteristics of the disease or even the tissue they derive from.

Objective: We aim to pinpoint factors distinguishing SeAx cells from two other cutaneous T-cell lymphoma (CTCL) cell lines, namely Hut78 and MyLa2000. Read More

Clin Case Rep 2021 May 19;9(5):e04194. Epub 2021 May 19.

Department of Haematology Sir Charles Gairdner Hospital Nedlands WA Australia.

Floaters or visual disturbance in a patient with ENKL should prompt evaluation for possible vitreoretinal involvement. Lymphoma with ocular involvement should be treated aggressively and in most cases heralds CNS involvement. Read More

Oncol Lett 2021 Jul 11;22(1):521. Epub 2021 May 11.

Department of Dermatology and Venerology, Aviation General Hospital, Beijing 100012, P.R. China.

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma. The majority of patients with advanced stage MF are resistant to conventional chemotherapy and thus have a poor prognosis. The transcriptional repressor growth factor independence-1 (GFI-1) serves an important role in the development of T-cells. Read More