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    11339 results match your criteria Cutaneous T-Cell Lymphoma

    1 OF 227

    Blood classification and blood response criteria in mycosis fungoides and Sézary syndrome using flow cytometry: recommendations from the EORTC cutaneous lymphoma task force.
    Eur J Cancer 2018 Feb 21;93:47-56. Epub 2018 Feb 21.
    Leiden University Medical Centre, The Netherlands.
    Our current mycosis fungoides (MF) and Sézary Syndrome (SS) staging system includes blood-classification from B0-B2 for patch/plaque/tumour or erythroderma based on manual Sézary counts but results from our EORTC survey confirm these are rarely performed in patch/plaque/tumour MF, and there is a trend towards using flow cytometry to measure blood-class. Accurately assigning blood-class effects overall stage and the 'global response' used to measure treatment responses in MF/SS and hence impacts management. The EORTC Cutaneous Lymphoma Task Force Committee have reviewed the literature and held a Workshop (June 2017) to agree a definition of blood-class according to flow cytometry. Read More

    Oral involvement of cutaneous T-cell lymphoma.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Tulane University School of Medicine, New Orleans, Louisiana.
    Methylisothiazolinone (MI) is commonly used as a preservative in personal care products and is a frequent cause of allergic contact dermatitis. We present a patient with allergic contact dermatitis caused by MI in hair care products and discuss this allergen to bring attention to this common cause of contact dermatitis, and to highlight its frequent use in hair care products. If allergy to MI is suspected, testing should be performed to this individual preservative, as testing solely for the combination preservative, methylisothiazolinone/methylchloroisothiazolinone (Kathon CG®), may miss many cases of MI allergy. Read More

    Folliculin mutation-negative trichodiscomas in a patient with multiple endocine neoplasia type I syndrome.
    Dermatol Online J 2017 Aug 15;23(8). Epub 2017 Aug 15.
    Harvard Medical School, Boston, Massachusetts.
    Mycosis fungoides (MF) is the most common cutaneous T cell lymphoma that involves the oral mucosal. The manifestation of lesions within the oral cavity generally correlates with a poor prognosis. Management of MF includes skin directed therapies and localized radiation treatment, with systemic biologic therapies and chemotherapy used for more advanced stages. Read More

    Comparison between 8-methoxypsoralen and 5-aminolevulinic acid in killing T cells of photopheresis patients ex vivo.
    Lasers Surg Med 2018 Feb 20. Epub 2018 Feb 20.
    Department of Pathology, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, N-0379, Norway.
    Background And Objective: Extracorporeal photopheresis (ECP), an established modality for cutaneous T-cell lymphoma (CTCL) and graft-versus-host disease, involves ex vivo treatment of isolated leukocytes of a patient with the photosensitizing drug 8-methoxypsoralen (8-MOP) and ultraviolet-A (UV-A) exposure before reinfusion back to the patient. However, 8-MOP binds to both diseased and normal cells and thus kills both types of the cells after UV-A illumination with little selectivity. Clinically, this modality gives only partial response in the majority of treated patients. Read More

    The Efficacy and Safety of Methotrexate versus Interferon in Cutaneous T-cell Lymphomas.
    J Dermatolog Treat 2018 Feb 19:1-22. Epub 2018 Feb 19.
    a Department of Dermatology , Westmead Hospital , Sydney , Australia.
    Objectives: Methotrexate and interferon have been used in the treatment of cutaneous T-cell lymphomas of various subtypes. We review our experience of methotrexate and interferon use in our patients with cutaneous T-cell lymphoma at a tertiary hospital.

    Materials And Methods: Medical records of patients over four years were reviewed. Read More

    "It's a traumatic illness, traumatic to witness." A qualitative study of the experiences of bereaved family caregivers of patients with cutaneous T-cell lymphoma.
    Br J Dermatol 2018 Feb 16. Epub 2018 Feb 16.
    King's College London, Cicely Saunders Institute, Dept. Palliative Care, Policy& Rehabilitation.
    Background: Cutaneous T-cell lymphomas (CTCL) are rare cancers which can be difficult to diagnose, are incurable and adversely affect quality of life, particularly in advanced disease. Families often provide care, but little is known about their experiences or needs while caring for their relative with advanced disease or in bereavement.

    Objectives: To explore the experiences of bereaved family caregivers of patients with CTCL. Read More

    Apheresis buffy coat collection without photoactivation has no effect on apoptosis, cell proliferation, and total viability of mononuclear cells collected using photopheresis systems.
    Transfusion 2018 Feb 16. Epub 2018 Feb 16.
    Bone Marrow Transplant Program, University of Kansas Medical Center, Kansas City, Kansas.
    Background: Extracorporeal photopheresis (ECP) has been approved for the treatment of advanced cutaneous T-cell lymphoma since 1988. While the precise mechanisms resulting in clinical effects are not fully understood, the photoactivation of mononuclear cells (MNCs) using ultraviolet A (UVA) light and methoxsalen is believed to be the predominant initiating process. The effects of MNC passage through the instrument without photoactivation are unknown. Read More

    A diagnostically challenging case of CD8+ primary cutaneous gamma/delta T-cell lymphoma.
    Dermatol Online J 2017 Nov 15;23(11). Epub 2017 Nov 15.
    School of Medicine, University of Rochester. Rochester, New York. rochester.edu.
    Primary cutaneous gamma/delta T-cell lymphoma (PCγδTCL) is a rare form of cutaneous lymphoma characterized by abnormal clonal proliferation of mature, activated gamma-delta T cells expressing the γδ heterodimer of the T-cell receptor (TCR). As an entity, PCγδTCL has recently undergone diagnostic revision since its introduction in the 2008 WHO classification of cutaneous lymphomas and confirmedin 2016. Nonetheless, diagnosis remains difficult both clinically and histologically, given its broad range of clinical manifestations and immunohistochemical phenotypes. Read More

    Primary cutaneous small/medium-sized pleomorphic T-cell lymphoproliferative disorder shows a common vascular pattern at dermoscopy.
    J Eur Acad Dermatol Venereol 2018 Feb 14. Epub 2018 Feb 14.
    Università degli Studi di Bologna Azienda Ospedaliera Sant'Orsola-Malpighi Dermatology Unit Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
    Primary cutaneous small/medium-sized pleomorphic T-cell lymphoproliferative disorder (PCSM-TCLPD) is a rare and indolent primary cutaneous T-cell lymphoma variant [1], usually presenting as a solitary nodule or plaque in the head and neck [2] or rarely as multiple lesions in anatomic areas apart from head and neck [2]. Histology reveals the presence of a dense dermal infiltrate of CD4+, CD8-, small/medium pleomorphic cells [2] intermingled with reactive cells. Surgical or radiotherapic approach are the preferred option, while oral doxycycline has been suggested in cases with multiple lesions [2-3]. Read More

    Vascular access considerations for extracorporeal photopheresis.
    Transfusion 2018 Feb;58 Suppl 1:590-597
    Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Phoenix, Arizona.
    Extracorporeal photopheresis is an immunomodulatory therapy indicated for patients with cutaneous T-cell lymphoma, graft-versus-host disease, and heart or lung allograft rejection. Whole blood from the patient is drawn into the photopheresis instrument where it is separated into its components. Plasma, red blood cells, and the treated buffy coat are subsequently returned to the patient. Read More

    Allogeneic hematopoietic stem cell transplantation in Primary Cutaneous T Cell Lymphoma.
    Ann Hematol 2018 Feb 13. Epub 2018 Feb 13.
    Immunohematology, University Tor Vergata, Rome, Italy.
    In our retrospective study, 16 patients affected by advanced cutaneous T cell lymphoma (CTCL) underwent allogeneic hematopoietic stem cell transplantation (HSCT). Two patients (12.5%) were in complete remission (CR), nine (56. Read More

    Clinical potential of mechlorethamine gel for the topical treatment of mycosis fungoides-type cutaneous T-cell lymphoma: a review on current efficacy and safety data.
    Drug Des Devel Ther 2018 31;12:241-254. Epub 2018 Jan 31.
    Department of Hematology/Oncology, Levine Cancer Institute, Carolinas Medical Center, Charlotte, NC, USA.
    Nitrogen mustard is a chemotherapeutic agent that has a well-documented safety and efficacy profile in the treatment of cutaneous T-cell lymphoma. Development of nitrogen mustard formulations and treatment regimens has been studied extensively over the last 40 years. In the last 5 years, a new gel formulation has been developed that is associated with a decrease in delayed hypersensitivity reactions. Read More

    A Phase I Dose-Escalation Study of Clofarabine in Patients with Relapsed or Refractory Low-Grade or Intermediate-Grade B-Cell or T-Cell Lymphoma.
    Oncologist 2018 Feb 7. Epub 2018 Feb 7.
    Yale University School of Medicine, New Haven, Connecticut, USA.
    Lessons Learned: Clofarabine can be active in relapsed and refractory lymphoid malignancies on a weekly dosing schedule.Responses were seen in patients with T-cell lymphomas, including cutaneous T-cell lymphoma, but not in patients with aggressive B-cell lymphomas.

    Background: Clofarabine is a second-generation purine nucleoside analog currently approved for the treatment of pediatric relapsed or refractory acute lymphoblastic leukemia. Read More



    Chronic activation profile of circulating CD8+ T cells in Sézary syndrome.
    Oncotarget 2018 Jan 16;9(3):3497-3506. Epub 2017 Dec 16.
    Cutaneous Lymphoma Clinic, Hospital das Clinicas, Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.
    Sézary syndrome (SS) is a leukemic variant of cutaneous T cell lymphoma (CTCL), and the neoplastic CD4+ T cells of SS patients undergo intense clonal proliferation. Although Sézary cells have been studied extensively, studies on adaptive immunity regarding CD8+T cells are scarce. This study aimed to investigate activation marker expression in CD8+ T cells according to the differentiation stages and IL-7/IL7Rα axis responses of patients with SS. Read More

    Serum metabolite profiling of cutaneous T-cell lymphoma based on a multiplatform approach.
    J Chromatogr B Analyt Technol Biomed Life Sci 2018 Mar 31;1077-1078:71-76. Epub 2018 Jan 31.
    School of Pharmacy, Fudan University, Shanghai 201203, PR China. Electronic address:
    Cutaneous T-cell lymphoma (CTCL) is a class of non-Hodgkin lymphoma with a difficult early diagnosis. The overall annual age-adjusted incidence of CTCL had consistently increased to around 10.2 cases per million persons. Read More

    Overcoming resistance to DNA targeted agents by epigenetic activation of Schlafen 11 (expression with class I histone deacetylase inhibitors.
    Clin Cancer Res 2018 Feb 1. Epub 2018 Feb 1.
    Center for Cancer Research,, National Cancer Institute
    Purpose: Schlafen 11 (SLFN11), a putative DNA/RNA helicase is a dominant genomic determinant of response to DNA damaging agents and is frequently not expressed in cancer cells. Whether histone deacetylase (HDAC) inhibitors can be used to releaseand sensitize SLFN11-inactivated cancers to DNA-targeted agents is tested here.

    Experimental Design: expression was examined in The Cancer Genome Atlas (TCGA), in cancer cell line databases and in patients treated with romidepsin. Read More

    Post-transplant malignancies in pediatric liver transplant recipients: Experience of two centers in Turkey.
    Turk J Gastroenterol 2018 Jan;29(1):87-91
    Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University School of Medicine, İzmir, Turkey.
    Background/aims: A liver transplant is the preferred treatment for patients with end-stage liver disease, as it usually results in longterm survival. However, due to the use of chronic immunosuppressive therapy, which is necessary to prevent rejection, de novo cancer is a major risk after transplantation. The aim of this study was to assess the incidence of post-transplant malignancies in children after liver transplantations. Read More

    High-frequency ultrasonography-New non-invasive method in assessment of skin lymphomas.
    Skin Res Technol 2018 Jan 31. Epub 2018 Jan 31.
    Department of Dermatology, University of Medical Sciences, Poznań, Poland.
    Background: Mycosis fingoides (MF) is the most common subtype of primary cutaneous T-cell lymphomas. Current evaluation of disease extent and severity is based on mSWAT scoring system, which seems to be relatively subjective. The aim of this subject was to present the usefulness of 20 MHz in objective 5-year long monitoring of response to therapy in MF patients. Read More

    Extranodal natural killer/T-cell lymphoma, nasal type, in Senegal.
    Int J Dermatol 2018 Jan 30. Epub 2018 Jan 30.
    Department of Dermatology, Aristide LeDantec University Hospital, Dakar, Senegal.
    Introduction: The distribution of extranodal NK/T-cell lymphoma (ENKTCL) is highly inhomogeneous throughout the world. In Sub-Saharan Africa, despite the precocity of Epstein-Barr virus (EBV) infection and its endemicity, ENKTCL remains exceptionally reported. The purpose of this study was to report the epidemiological, clinical, paraclinical, and evolutionary characteristics of ENKTCL at the Aristide LeDantec University Hospital in Dakar, Senegal. Read More

    Cutaneous intravascular CD30+ T-cell pseudolymphoma occurring in a regressing keratoacanthoma.
    J Cutan Pathol 2018 Jan 25. Epub 2018 Jan 25.
    Associates in Dermatology, MD PL, Fort Myers, Florida.
    Cutaneous intravascular CD30+ pseudolymphoma is an uncommon incidental finding that may mimic intravascular or angiotropic lymphoma. We describe a 78-year-old female with a traumatized regressing keratoacanthoma on her left cheek. A shave biopsy was performed which revealed intravascular staining of atypical lymphocytes positive for CD45, CD3 and CD30. Read More

    Primary cutaneous anaplastic large-cell lymphoma: A case report.
    Medicine (Baltimore) 2018 Jan;97(4):e9645
    Rationale: Primary cutaneous anaplastic large-cell lymphoma (C-ALCL) is a rare cancer belonging to the group of primary T-cell lymphoproliferative diseases. C-ALCL is characterized by the presence of single or multiple ulcerated lesions on the skin's surface.

    Patient Concerns: This is the case of a 73-year-old man who reported to the Clinic of Cranio-Maxillofacial and Oral Surgery and Implantology, Medical University of Warsaw, owing to a skin tumor in the right parotideomasseteric region, initially diagnosed as discoid lupus erythematosus. Read More

    E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma: A phase 1 study.
    Cancer Sci 2018 Jan 24. Epub 2018 Jan 24.
    Department of Clinical Development, Eisai Co Ltd, Tokyo.
    E7777, a recombinant cytotoxic fusion protein comprising diphtheria toxin fragments A and B and human interleukin-2, shares an amino acid sequence with denileukin diftitox but has improved purity and an increased percentage of active protein monomer species. A phase 1 study was conducted to evaluate the tolerability, safety, pharmacokinetics and anti-tumour activity of E7777 in Japanese patients with relapsed/refractory peripheral and cutaneous T-cell lymphoma. E7777 (6, 12 and expanded 9 μg/kg/day) was administered to 13 patients via intravenous infusion on 5 consecutive days per 21-day cycle. Read More

    Drug induced pseudolymphoma.
    Semin Diagn Pathol 2018 Jan 17. Epub 2018 Jan 17.
    Regional Medical Laboratory, 4142 South Mingo Road, Tulsa, OK 74146-3632, United States.
    Atypical lymphocytic infiltrates of the skin comprise a broad spectrum of entities ranging from benign infiltrates to those that are malignant. Many of these infiltrates are in fact reactive lymphomatoid ones related to drug therapy falling under the general category of drug associated pseudolymphoma. Within this nosologic umbrella are nodular and diffuse infiltrates resembling low grade T and B cell lymphoma consistent with lymphocytoma cutis, drug associated reversible T cell dyscrasias which draw a strong morphologic and phenotypic parallel with mycosis fungoides and the various pre-lymphomatous T cell dyscrasias, and angiocentric CD30 positive infiltrates mirroring lymphomatoid papulosis. Read More

    Aprepitant did not modify global disease activity in cutaneous T cell lymphomas.
    Br J Dermatol 2018 Jan 20. Epub 2018 Jan 20.
    Department of Dermatology Hospital Universitario 12 de Octubre, Instituto de Investigación i+12Medical School, Universidad Complutense-Madrid.
    Recent investigations are focused on the potential antitumor effect of neurokinin-1 receptor (NK1R) antagonists in different neoplastic diseases. Consequently, Kwatra et al. raised an interesting observation about the possible influence of aprepitant on CTCL outcome. Read More

    Effects of neuroimmune axis modulation by aprepitant on anti-pruritic and global disease severity in patients with cutaneous T-cell lymphoma.
    Br J Dermatol 2018 Jan 20. Epub 2018 Jan 20.
    Department of Anesthesiology, Duke University Medical Center, Durham, NC.
    Itch pathogenesis involves modulation of the neuroimmune axis, with several immunosuppressants such as azathioprineand mycophenolate mofetildemonstrating significant anti-pruritic activity in subsets of patients with pruritus. These immunosuppressive agents are contraindicated in patients with malignancy, and thus there is a need for novel anti-pruritic agents without significant immunosuppressive effects in neoplastic conditions such as cutaneous T cell lymphoma (CTCL). This article is protected by copyright. Read More

    Current Perspectives on Erythema Multiforme.
    Clin Rev Allergy Immunol 2018 Feb;54(1):177-184
    Unité d'allergologie, Service d'immunologie et d'allergologie, Hôpitaux Universitaires de Genève HUG, Rue Micheli-du-Crest 24, CH-1211, Genève, Switzerland.
    Recognition and timely adequate treatment of erythema multiforme remain a major challenge. In this review, current diagnostic guidelines, potential pitfalls, and modern/novel treatment options are summarized with the aim to help clinicians with diagnostic and therapeutic decision-making. The diagnosis of erythema multiforme, that has an acute, self-limiting course, is based on its typical clinical picture of targetoid erythematous lesions with predominant acral localization as well as histological findings. Read More

    Mogamulizumab-induced photosensitivity in patients with mycosis fungoides and other T-cell neoplasms.
    J Eur Acad Dermatol Venereol 2018 Jan 16. Epub 2018 Jan 16.
    Department of Dermatology, Hamamatsu University School of Medicine, Hamamatsu, Japan.
    Background: Mogamulizumab (Mog) is a defucosylated, therapeutic monoclonal antibody, targeting CCR4 and was first approved in Japan for the treatment of adult T-cell leukaemia/lymphoma (ATLL), followed by cutaneous T-cell lymphoma and peripheral T-cell lymphoma.

    Objective: To retrospectively investigate development of photosensitivity in patients with mycosis fungoides and other T-cell neoplasms after treatment with Mog.

    Methods: We treated seven cutaneous lymphoma patients with Mog. Read More

    SNF5 deficiency induces apoptosis resistance by repressing SATB1 expression in Sézary syndrome.
    Leuk Lymphoma 2018 Jan 16:1-9. Epub 2018 Jan 16.
    a Department of Cell Biology , 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Laboratory of Epigenetics in Development and Tumorigenesis, Tianjin Research Center of Basic Medical Sciences, Tianjin Key Laboratory of Medical Epigenetics, Tianjin Medical University , Tianjin , China.
    SNF5, is a core member of the SWI/SNF chromatin remodeling complex. It's deficiency leads to multiple types of aggressive cancer. Sézary syndrome, a leukemic variant of cutaneous T-cell lymphoma, is characterized by its resistance to apoptosis. Read More

    Survival outcomes of primary cutaneous T-cell lymphoma in HIV-infected patients: a national population-based study.
    J Investig Med 2018 Jan 12. Epub 2018 Jan 12.
    Department of Hematology, Xijing Hosptial, Fourth Military Medical University, Xi'an, China.
    This study aimed to investigate clinical characteristics and survival outcomes of primary cutaneous T-cell lymphoma (CTCL) in HIV-infected and non-HIV-infected patients. All data were from the Surveillance, Epidemiology, and End Results program, 1973-2013, of the U.S. Read More

    Synchronous Occurrence of Mycosis Fungoides, Diffuse Large B cell Lymphoma and Acute Myeloid Leukemia: A Report of Two Cases.
    Intern Med 2018 Jan 11. Epub 2018 Jan 11.
    Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan.
    Patients with mycosis fungoides (MF), the most common subtype of primary cutaneous T-cell lymphoma, have an increased risk of developing secondary malignancies. We herein report two rare cases of MF concurring with diffuse large B cell lymphoma (B lymphoid lineage) and acute myeloid leukemia (myeloid lineage) in two otherwise healthy elderly patients. Potential etiologic factors, including the impact of the therapy-associated inflammatory response on the development of secondary tumors in patients with MF, are discussed. Read More

    4,6,4'-trimethylangelicin shows high anti-proliferative activity on DU145 cells under both UVA and blue light.
    Cell Prolif 2018 Jan 10. Epub 2018 Jan 10.
    Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Padova, Italy.
    Objectives: Furocoumarins (psoralens and angelicins) have been already used under ultraviolet A light (UVA) for the treatment of skin diseases and cutaneous T-cell lymphoma. Besides their high anti-proliferative activity, some severe long-term side effects have been observed, for example genotoxicity and mutagenicity, likely strictly related to the formation of crosslinks. It has been demonstrated that blue light (BL) activation of 8-methoxypsoralen, an FDA-approved drug, leads to less mutagenic monoadducts in the DNA. Read More

    Etoposide as a single agent in the treatment of mycosis fungoides: A retrospective analysis.
    Dermatol Ther 2018 Jan 9. Epub 2018 Jan 9.
    Department of Dermatology, Indiana University School of Medicine, Indianapolis, Indiana.
    Several chemotherapy agents have shown efficacy in the treatment of mycosis fungoides (MF). In the literature, there is limited data on the use of single agent etoposide for MF. We aimed to retrospectively review our experience with single agent etoposide in the treatment of advanced-stage or refractory early-stage MF with focus on analyzing its efficacy and safety. Read More

    Pityriasis lichenoides: Long-term follow-up study.
    Pediatr Dermatol 2018 Jan 9. Epub 2018 Jan 9.
    Department of Dermatology, School of Medicine, Johns Hopkins University, Baltimore, MD, USA.
    Background/objectives: Pityriasis lichenoides is an uncommon papulosquamous disorder of unknown etiology. The objective of this study was to review the clinical features and treatment responses of individuals with pityriasis lichenoides seen at a tertiary referral center.

    Methods: Seventy-five patients diagnosed with pityriasis lichenoides between 1997 and 2013 were reviewed, and 46 had long-term follow-up via telephone interviews. Read More

    Current systemic therapeutic options for advanced mycosis fungoides and Sézary syndrome.
    Leuk Lymphoma 2018 Mar 8;59(3):562-577. Epub 2018 Jan 8.
    d Department of Medicine, Section of Dermatology , University of Chicago Medicine and Biological Sciences , Chicago , IL , USA.
    Mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous T-cell lymphomas (CTCLs). Both lack curative options, and advanced-stage carries a poor prognosis. Whilst there are a number of treatments available, achieving and maintaining a durable remission remains challenging. Read More

    Progression of undiagnosed cutaneous lymphoma after anti-tumor necrosis factor alpha therapy.
    J Am Acad Dermatol 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, Northwestern University, Feinberg School of Medicine, Northwestern Medicine, Chicago, IL. Electronic address:
    Background: Cutaneous lymphoma (CL) diagnosed after anti-tumor necrosis factor (TNF)α therapy has been reported in the literature, yet a clear link between both events remains elusive.

    Objective: To review our experience with CL diagnosed during or after the use of anti-TNFα therapies.

    Methods: This is a multicenter retrospective study and a literature review. Read More

    PAK1 overexpression promotes cell proliferation in cutaneous T cell lymphoma via suppression of PUMA and p21.
    J Dermatol Sci 2018 Jan 4. Epub 2018 Jan 4.
    Department of Dermatology, Peking University Third Hospital, Beijing, China. Electronic address:
    Background: Cutaneous T cell lymphoma (CTCL) comprises a heterogeneous group of skin-homing T cell tumors. The small guanosine triphosphate effector p21-activated kinase 1 (PAK1) plays an important role in many fundamental cellular functions, including cell motility, proliferation, and apoptosis. The expression of PAK1 is up-regulated in several types of human cancers. Read More

    Identification of OAF and PVRL1 as candidate genes for an ocular anomaly characterized by Peters anomaly type 2 and ectopia lentis.
    Exp Eye Res 2018 Jan 2;168:161-170. Epub 2018 Jan 2.
    Department of Human Genetics, National Health Institute Doutor Ricardo Jorge, Lisbon, Portugal.
    Keratolenticular dysgenesis (KLD) and ectopia lentis are congenital eye defects. The aim of this study is the identification of molecular genetic alterations responsible for those ocular anomalies with neurologic impairment in an individual with a de novo balanced chromosome translocation t(11;18)(q23.3;q11. Read More

    Mogamulizumab Tops Standard of Care for CTCL.
    • Authors:
    Cancer Discov 2018 Feb 3;8(2):OF1. Epub 2018 Jan 3.
    In the large international phase III MAVORIC trial, patients with previously treated cutaneous T-cell lymphoma who received the anti-CCR4 monoclonal antibody mogamulizumab experienced significantly longer progression-free survival and higher response rates, as well as better quality of life, than those who received vorinostat, a standard therapy. Read More

    CD30+ Cutaneous Anaplastic Large-Cell Lymphoma of the Upper Eyelid: A Case Report.
    Case Rep Dermatol 2017 Sep-Dec;9(3):206-210. Epub 2017 Oct 20.
    Department of Dermatology, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium.
    CD30+ cutaneous anaplastic large-cell lymphoma is part of the CD30+ T-cell lymphoproliferative disorders. This type of lymphoma is in most cases indolent, with a high survival rate. We report the case of a 59-year-old patient with a 1-month lasting crusty lesion of the upper eyelid. Read More

    Mycosis fungoides occurring at the site of previous herpes zoster eruption.
    Australas J Dermatol 2017 Dec 26. Epub 2017 Dec 26.
    Department of Dermatology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA.
    Numerous clinicopathological variants of mycosis fungoides have been described in the literature. Dermatomal or zosteriform mycosis fungoides is one reported variant but a clear aetiology has never been documented. We report a case of mycosis fungoides proved by biopsy and immunohistochemistry that developed in a 55-year-old man at the site of previous herpes zoster eruption. Read More

    [Histopathology of cutaneous drug reactions].
    Ann Pathol 2018 Feb 24;38(1):7-19. Epub 2017 Dec 24.
    Département de pathologie, hôpital Henri-Mondor, 51, avenue du Maréchal-de-Lattre-de-Tassigny, 94010 Créteil, France. Electronic address:
    There are many different types of cutaneous adverse reactions. The most classical reactions are driven by T lymphocytes that specifically react towards a drug, with an individual genetic susceptibility linked to certain type I major histocompatibility complex alleles. These reactions are characterized by a wide variety of clinical and histopathological presentations, and a wide range of severity. Read More

    Folliculotropic mycosis fungoides: challenging clinical, histopathological and immunohistochemical diagnosis.
    An Bras Dermatol 2017 ;92(5 Suppl 1):73-75
    Department of Morphology, Universidade Federal de Juiz de Fora (UFJF) - Juiz de Fora (MG), Brazil.
    Mycosis fungoides is a cutaneous T-cell lymphoma with various clinical and pathological presentations. Early lesions are nonspecific, which hinders early diagnosis. The folliculotropic subtype is manifested as acneiform lesions, follicular papules or erythematous plaques mainly on the face, neck and upper trunk. Read More

    Fusion of the genes ataxin 2 like,, and Janus kinase 2,, in cutaneous CD4 positive T-cell lymphoma.
    Oncotarget 2017 Nov 10;8(61):103775-103784. Epub 2017 Oct 10.
    Section for Cancer Cytogenetics, Institute for Cancer Genetics and Informatics, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway.
    Acquired mutations were recently described in cutaneous T-cell lymphomas for the,,, andgenes of the JAK-STAT pathway. In the present study, RNA-sequencing of a primary cutaneous CD4 positive T-cell lymphoma carrying a three-way t(9;13;16)(p24;q34;p11) chromosome translocation showed thatfrom chromosome band 9p24 was rearranged and fused to a novel partner gene,, from 16p11. RT-PCR together with Sanger sequencing verified the presence of thefusion transcript. Read More

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