11,915 results match your criteria Cutaneous T-Cell Lymphoma


Ingenol mebutate for mycosis fungoides.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Ingenol mebutate is a macrocyclic diterpene ester, naturally found in the sap of the Australian plant Euphorbia peplus, which proved efficacious for actinic keratosis. In clinical routine, we observed local improvement of MF upon application of ingenol mebutate in MF patients treated for coincidental actinic keratosis within direct proximity of/overlapping with MF skin lesions. Hence, the objective of this study was to assess the effect of topical ingenol mebutate on MF skin lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18018
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http://dx.doi.org/10.1111/bjd.18018DOI Listing
April 2019
4 Reads

Primary cutaneous CD4+ small-/medium-sized T-cell lymphoproliferative disorder: A case report.

Clin Case Rep 2019 Apr 22;7(4):703-706. Epub 2019 Feb 22.

Department of Dermatology and Venereology Medical University of Lodz Lodz Poland.

Primary cutaneous CD4+ small-/medium-sized T-cell lymphoproliferative disorder is usually characterized by nodules and plaques affecting the upper part of the body. The present case presented with a large, single tumor located on a lower extremity. The patient did not respond to surgical therapy but responded to cyclophosphamide, methotrexate, and radiotherapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2018
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http://dx.doi.org/10.1002/ccr3.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452474PMC
April 2019
5 Reads

Special Considerations in the Treatment of Mycosis Fungoides.

Am J Clin Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology and Cutaneous Biology, Sidney Kimmel College at Jefferson University Hospital, Thomas Jefferson University, 833 Chestnut Street, Suite 740, Philadelphia, PA, 19107, USA.

Mycosis fungoides is the most common form of cutaneous T cell lymphoma. Although normally presenting to physicians at an early stage and with an indolent course, mycosis fungoides can have a varied presentation. The National Comprehensive Cancer Network (NCCN) has created guidelines for the treatment and staging of mycosis fungoides. Read More

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http://dx.doi.org/10.1007/s40257-019-00431-zDOI Listing
April 2019
8 Reads

Mycosis Fungoides with Spongiosis: a Potential Diagnostic Pitfall.

J Cutan Pathol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Mayo Clinic Rochester, Minnesota.

Background: Mycosis fungoides (MF) is characterized by epidermotropic atypical lymphocytes in the absence of spongiosis. However , we describe a unique presentation of MF with spongiosis, mimicking benign inflammatory dermatoses and highlight the importance of pathologic interpretation for diagnostic confirmation.

Methods: A cross-sectional study of consecutive patients diagnosed with MF with spongiosis was conducted. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13477
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http://dx.doi.org/10.1111/cup.13477DOI Listing
April 2019
6 Reads

Extranasal extranodal NK/T cell lymphoma: A post-transplantation lymphoproliferative disease.

Int Wound J 2019 Apr 14. Epub 2019 Apr 14.

Department of Dermatology, Medical Faculty, Ege University, Izmir, Turkey.

Extranodal NK/T cell lymphoma (ENKTL) is a rare form of non-Hodgkin lymphoma. It mostly occurs in the upper respiratory tract. Cutaneous involvement can be seen among the extranasal ENKTLs. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/iwj.13126
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http://dx.doi.org/10.1111/iwj.13126DOI Listing
April 2019
8 Reads

Cutaneous Lesions of Angioimmunoblastic T-cell Lymphoma: Clinical, Pathological, and Immunophenotypic Features.

J Cutan Pathol 2019 Apr 12. Epub 2019 Apr 12.

Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota.

Background: Angioimmunoblastic T-cell lymphoma (AITL) is a systemic peripheral T-cell lymphoma with a follicular helper T-cell (T ) immunophenotype that frequently involves the skin. However, the histopathology of cutaneous involvement by AITL has not been fully established.

Methods: We reviewed the clinicopathological features of 19 patients seen at our institution with AITL involving the skin. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13475
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http://dx.doi.org/10.1111/cup.13475DOI Listing
April 2019
4 Reads

The Conundrum of Diagnosing Cutaneous Composite Lymphoma in the Molecular Age.

Am J Dermatopathol 2019 Apr 2. Epub 2019 Apr 2.

Department of Pathology, Loyola University Chicago, Maywood, IL.

Introduction: Cutaneous composite lymphoma (CCL) is extremely rare. When 2 potentially distinct lymphoid lesions occur at one skin site, distinguishing between one neoplastic clone and a secondary reactionary lymphoid response versus a second neoplasm is difficult. In this study, we describe a unique case of CCL along with a review of reported cases in literature to identify clues and discuss issues that are relevant to the diagnosis of CCL. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001424DOI Listing
April 2019
7 Reads

Pagetoid reticulosis positive for cytotoxic CD20 and CD30: A case report.

Indian J Pathol Microbiol 2019 Apr-Jun;62(2):316-318

Department of Pathology, Jiujiang University Hospital, No. 57, Xunyangdong Road, Jiujiang, Jiangxi, China.

Pagetoid reticulosis is an indolent cutaneous T-cell lymphoma and presents as erythema or plaque with a well-defined border on the distal areas of the extremities. Immunophenotypic studies show that in most cases, neoplastic lymphocytes are positive for CD4, whereas CD20 and CD30 double positivity was rarely reported. In this paper, we report an 80-year-old woman who presented with erythema on the extremities for 3 years. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_717_18DOI Listing
April 2019
1 Read

Clonotypic heterogeneity in cutaneous T-cell lymphoma (mycosis fungoides) revealed by comprehensive whole-exome sequencing.

Blood Adv 2019 Apr;3(7):1175-1184

Division of Dermatology, Department of Medicine, and.

Mycosis fungoides (MF), the most common type of cutaneous T-cell lymphoma, is believed to represent a clonal expansion of a transformed skin-resident memory T cell. T-cell receptor (TCR) clonality (ie, identical sequences of rearranged TCRα, TCRβ, and TCRγ), the key premise of this hypothesis, has been difficult to document conclusively because malignant cells are not readily distinguishable from the tumor-infiltrating reactive lymphocytes that contribute to the TCR clonotypic repertoire of MF. Here, we have successfully adopted targeted whole-exome sequencing (WES) to identify the repertoire of rearranged TCR genes in tumor-enriched samples from patients with MF. Read More

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2018027482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457216PMC
April 2019
7 Reads

CD4/CD8 Double-negative Mycosis Fungoides: A Case Report and Literature Review.

Yonago Acta Med 2019 Mar 28;62(1):153-158. Epub 2019 Mar 28.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan.

Mycosis fungoides, the most common subtype of cutaneous T-cell lymphoma, displays a broad spectrum of clinical, histological and phenotypic variants with different prognostic impacts. The classic immunophenotype is CD3+/CD4+/CD45RO+memory T cells. CD4/CD8 double-negative mycosis fungoides is rare. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437399PMC
March 2019
6 Reads

Management of mycosis fungoides-type cutaneous T-cell lymphoma (MF-CTCL): focus on chlormethine gel.

Cancer Manag Res 2019 20;11:2241-2251. Epub 2019 Mar 20.

Dermatology Department, Centre Hospitalier Le Mans, Le Mans, France,

Mycosis fungoides (MF) is a low-grade cutaneous lymphoma accounting for more than half of primary cutaneous T-cell lymphomas (CTCLs). Due to the rarity of CTCL, randomized studies are lacking, and treatment is based mainly on the recent published European Organisation for Research and Treatment of Cancer guidelines. Basically, early-stage MF is treated with skin-directed treatments, whereas advanced-stage MF requires more aggressive therapies. Read More

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https://www.dovepress.com/management-of-mycosis-fungoides-ty
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http://dx.doi.org/10.2147/CMAR.S138661DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6433101PMC
March 2019
10 Reads

Targeting CD47 in Sézary syndrome with SIRPαFc.

Blood Adv 2019 Apr;3(7):1145-1153

Department of Dermatology, University of Pittsburgh, Pittsburgh, PA.

Sézary syndrome (SS), the leukemic variant of cutaneous T-cell lymphoma, has limited treatment options and rare occurrences of long-term remission, thus warranting research into new treatment approaches. CD47 has emerged as a promising target for multiple tumor types, but its role in SS remains unknown. Here, we show that CD47 is highly expressed on Sézary cells in the peripheral blood and skin, and the high level of CD47 expression correlates with worse overall survival (OS) in patients with SS. Read More

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http://www.bloodadvances.org/lookup/doi/10.1182/bloodadvance
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http://dx.doi.org/10.1182/bloodadvances.2018030577DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457236PMC
April 2019
8 Reads

Cutaneous mantle cell lymphoma histomorphologically mimicking subcutaneous panniculitis-like T-cell lymphoma: Case report.

J Cutan Pathol 2019 Apr 8. Epub 2019 Apr 8.

Department of Dermatology, University of Utah, Salt Lake City, Utah.

Secondary cutaneous involvement by mantle cell lymphoma (MCL), an uncommon aggressive B-cell malignancy, predominantly involves the dermis, with few reports of pannicular involvement. Lymphocytic infiltration of subcutaneous tissue is associated with inflammatory panniculitides and certain T-cell lymphomas, primarily subcutaneous panniculitis-like T-Cell lymphoma (SPTCL), which is characterized by rimming of adipocytes by tumor cells. This article is protected by copyright. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/cup.13471
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http://dx.doi.org/10.1111/cup.13471DOI Listing
April 2019
11 Reads

Harnessing the synergistic potential of biologically targeted therapies in cutaneous T-cell lymphoma.

Oncotarget 2019 Mar 8;10(20):1860-1861. Epub 2019 Mar 8.

Associate Professor of Dermatology and Director of the Comprehensive Skin Cancer Center, Department of Dermatology, Columbia University Irving Medical Center, New York, NY, USA.

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http://dx.doi.org/10.18632/oncotarget.26751DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6443007PMC
March 2019
1 Read

[Primary cutaneous acral CD8+ T-cell lymphoma: report of a case].

Zhonghua Bing Li Xue Za Zhi 2019 Apr;48(4):336-337

Department of Pathology, the Hospital of Zhejiang General Corps of Armed Police Forces, Jiaxing 314000, China.

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http://dx.doi.org/10.3760/cma.j.issn.0529-5807.2019.04.020DOI Listing
April 2019
9 Reads

Epidemiology of primary cutaneous gamma/delta T-cell lymphoma and subcutaneous panniculitis-like T-cell lymphoma in the United States from 2006-2015: A Surveillance, Epidemiology, and End Results-18 analysis.

Br J Dermatol 2019 Apr 1. Epub 2019 Apr 1.

Department of Dermatology, University of Minnesota, Minneapolis, MN.

Primary cutaneous gamma/delta T-cell lymphoma (pcGDTCL) is a rare, aggressive T-cell lymphoma that presents with ulcerated nodules, extranodal dissemination, constitutional symptoms, and often, hemophagocytic lymphohistiocytosis (HLH). pcGDTCL is so named given the gamma/delta phenotype of the T-cell receptor (TCR). This article is protected by copyright. Read More

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http://dx.doi.org/10.1111/bjd.17985DOI Listing
April 2019
15 Reads

Mycosis Fungoides Associated With Lesions in the Spectrum of Primary Cutaneous CD30+ Lymphoproliferative Disorders: The Same Process or 3 Coexisting Lymphomas?

Am J Dermatopathol 2019 Mar 29. Epub 2019 Mar 29.

Departments of Dermatology.

Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, primary cutaneous CD30 lymphoproliferative disorders (pc CD30 LPD) being the second most prevalent. There is evidence that MF and pc CD30 LPD may coexist and share T-cell clonality, suggesting a common origin. These findings were supported by a T-cell receptor clonality assessment by the polymerase chain reaction coupled with capillary electrophoresis, although results produced by this method may be ambiguous. Read More

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http://Insights.ovid.com/crossref?an=00000372-900000000-9816
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http://dx.doi.org/10.1097/DAD.0000000000001423DOI Listing
March 2019
11 Reads

Angiogenesis in cutaneous T-cell lymphoma - proteomic approaches.

Oncol Lett 2019 May 19;17(5):4060-4067. Epub 2018 Nov 19.

Department of Biochemistry-Proteomics, 'Victor Babes' National Institute of Pathology, 050096 Bucharest, Romania.

Neoangiogenesis plays an important role in cutaneous lymphoma pathogenesis. Cutaneous T-cell lymphoma (CTCL) is characterized by the presence of malignant T-cell clones in the skin. Vascular microenvironment of lymphomas accelerates neoangiogenesis through several factors released by tumoral cells: VEGF family, bFGF and PIGF. Read More

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http://www.spandidos-publications.com/10.3892/ol.2018.9734
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http://dx.doi.org/10.3892/ol.2018.9734DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444338PMC
May 2019
7 Reads

Dendritic cell distribution in mycosis fungoides vs. inflammatory dermatosis and other T-cell skin lymphoma.

Oncol Lett 2019 May 1;17(5):4055-4059. Epub 2019 Mar 1.

Department of Pathology, Colentina University Hospital, 020125 Bucharest, Romania.

Dendritic cells (DCs) are antigen-presenting cells with an important role in the innate and adaptive immune system. In skin lesions, cutaneous DCs (Langerhans cells, dermal DCs and plasmacytoid DCs) are involved in immune activation in inflammatory benign lesions, as well as in malignant lymphoid proliferations. Density and distribution of DCs in the dermal infiltrate can be helpful to differentiate benign, reactive infiltrate from malignant nature of the lymphoid population. Read More

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http://dx.doi.org/10.3892/ol.2019.10097DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444333PMC
May 2019
3 Reads

Existing and Emerging Therapies for Cutaneous T-Cell Lymphoma.

J Cutan Med Surg 2019 Apr 3:1203475419840629. Epub 2019 Apr 3.

1 Department of Dermatology and Skin Science, University of British Columbia, Vancouver, Canada.

Cutaneous T-cell lymphomas (CTCL) are a heterogeneous group of non-Hodgkin lymphomas characterized by an infiltration of malignant monoclonal T lymphocytes into the skin. Mycosis fungoides (MF), the most common subtype, and the rarer Sézary syndrome (SS), are considered the classical forms of CTCL, which, because of a varying presentation and lack of genetic and immunophenotypical markers, can often have a delayed diagnosis. With skin-directed topical treatment being the mainstay of therapy in the early stages, there is an absence of long-term curative therapies for advanced disease. Read More

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http://journals.sagepub.com/doi/10.1177/1203475419840629
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http://dx.doi.org/10.1177/1203475419840629DOI Listing
April 2019
8 Reads

Composite Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma and T-Prolymphocytic Leukemia Presenting with Lymphocytosis, Skin Lesions, and Generalized Lymphadenopathy.

Case Rep Pathol 2019 3;2019:4915086. Epub 2019 Mar 3.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Chronic lymphocytic leukemia (CLL) is the most common type of leukemia in Western countries with an incidence of 3-5 cases per 100,000 persons. Most patients follow an indolent clinical course with eventual progression and need for therapy. In contrast, T-prolymphocytic leukemia (T-PLL) is a rare type of T-cell leukemia with most patients having an aggressive clinical course and a dismal prognosis. Read More

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https://www.hindawi.com/journals/cripa/2019/4915086/
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http://dx.doi.org/10.1155/2019/4915086DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420994PMC
March 2019
4 Reads

Characteristics, treatment patterns, prognostic determinants and outcome of peripheral T cell lymphoma and natural killer/T cell non-Hodgkin Lymphoma in older patients: The result of the nationwide multi-institutional registry Thai Lymphoma Study Group.

J Geriatr Oncol 2019 Mar 30. Epub 2019 Mar 30.

Department of Internal Medicine, Chulalongkorn University, Bangkok, Thailand.

Introduction: Peripheral T cell NHL (PTCL) and natural killer/T cell NHL (NKTCL) are relatively rare disorders. Data on clinical presentation, treatment and outcome are limited especially in older age groups.

Methods: We identified 127 patients with PTCL and NKTCL, excluding cutaneous T/NK cell lymphoma, aged over 60 years old from Thailand nationwide multicenter registry. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S18794068183036
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http://dx.doi.org/10.1016/j.jgo.2019.03.016DOI Listing
March 2019
10 Reads

Apoptosis Induction byHistone Deacetylase Inhibitors in Cancer Cells: Role of Ku70.

Int J Mol Sci 2019 Mar 30;20(7). Epub 2019 Mar 30.

Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China.

Histone deacetylases (HDACs) are a group of enzymes that regulate gene transcription by controlling deacetylation of histones and non-histone proteins. Overexpression of HDACs is found in some types of tumors and predicts poor prognosis. Five HDAC inhibitors are approved for the treatment of cutaneous T-cell lymphoma, peripheral T-cell lymphoma, and multiple myeloma. Read More

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https://www.mdpi.com/1422-0067/20/7/1601
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http://dx.doi.org/10.3390/ijms20071601DOI Listing
March 2019
5 Reads

Epstein-Barr Virus-Associated T and NK-Cell Lymphoproliferative Diseases.

Front Pediatr 2019 15;7:71. Epub 2019 Mar 15.

Institute of Pathology and Neuropathology and Comprehensive Cancer Center Tübingen, University Hospital Tübingen, Eberhard-Karls-University, Tübingen, Germany.

EBV-associated T and NK-cell lymphoproliferative diseases (EBV-T/NK LPDs) are characterized by the transformation and proliferation of EBV-infected T or NK cells. The 2016 revised World Health Organization classification recognizes the following EBV-positive lymphoproliferative disorders (LPD): chronic active EBV infection (CAEBV) of T- and NK-cell type (cutaneous and systemic forms), systemic EBV-positive T-cell lymphoma of childhood, aggressive NK-cell leukemia, extranodal NK/T-cell lymphoma, nasal type, and the new provisional entity primary EBV-positive nodal T/NK-cell lymphoma. EBV-associated hemophagocytic lymphohistiocytosis (HLH), although not included in the WHO classification because it is a reactive, inflammatory disease, is included in this review because it can be life-threatening and may have overlapping features with other EBV+ T/NK LPDs. Read More

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https://www.frontiersin.org/article/10.3389/fped.2019.00071/
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http://dx.doi.org/10.3389/fped.2019.00071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428722PMC
March 2019
6 Reads

Health-related quality of life and economic implications of cutaneous T-cell lymphoma.

Br J Dermatol 2019 Mar 28. Epub 2019 Mar 28.

Washington University School of Medicine, Division of Dermatology.

Background: Cutaneous T-cell lymphoma (CTCL) has been associated with considerable physical, psychological, and financial burden. However, its impact on health-related quality of life (QoL) and economic cost are not well-studied.

Objectives: To measure the QoL impact and financial burden of CTCL. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.17941
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http://dx.doi.org/10.1111/bjd.17941DOI Listing
March 2019
3 Reads

Nail Changes in Sézary Syndrome: A Single-Center Study and Review of the Literature.

J Cutan Med Surg 2019 Mar 27:1203475419839937. Epub 2019 Mar 27.

1 Cutaneous Lymphoma Program, Department of Dermatology, University of Pittsburgh Medical Center, PA, USA.

Background:: The onychodystrophies associated with Sézary syndrome (SzS) have rarely been described in the literature. We performed a retrospective analysis of SzS patients at a single institution and compared our data with previous publications.

Objectives:: The objectives of this study were to identify and describe the most frequent nail alterations in patients with SzS. Read More

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http://journals.sagepub.com/doi/10.1177/1203475419839937
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http://dx.doi.org/10.1177/1203475419839937DOI Listing
March 2019
3 Reads

Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review.

Case Rep Hematol 2019 20;2019:3540487. Epub 2019 Feb 20.

Mayo Clinic, Jacksonville, FL, USA.

Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement. Presentation with isolated skin involvement is very rare. Literature review revealed only one case report of primary cutaneous T-cell LBL. Read More

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https://www.hindawi.com/journals/crihem/2019/3540487/
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http://dx.doi.org/10.1155/2019/3540487DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6402200PMC
February 2019
5 Reads

Silent T-cell receptor cutaneous T-cell lymphoma associated to a clonal plasma cell proliferation.

Hematol Rep 2019 Feb 19;11(1):7841. Epub 2019 Feb 19.

Hematology Department.

Within T-cell lymphomas (TCL) there are 2 entities expressing gamma-delta TCR: hepatosplenic gamma-delta T-cell lymphoma (HSGDTL) and the primary cutaneous gamma-delta T-cell lymphoma (PCGDTL). PCGDTL is a rare form of Tcell lymphoma with specific tropism for skin that have a dismal prognosis. Although even rarer, there have been reports of TCL with loss of expression of the TCR, which have been termed peripheral TCL TCR-silent type. Read More

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https://www.pagepress.org/journals/index.php/hr/article/view
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http://dx.doi.org/10.4081/hr.2019.7841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6397994PMC
February 2019
5 Reads

Histone Deacetylases (HDACs) Guided Novel Therapies for T-cell lymphomas.

Int J Med Sci 2019 29;16(3):424-442. Epub 2019 Jan 29.

China Central Laboratory of Peking University Shenzhen Hospital, Shenzhen, Guangdong, 518036, China.

T-cell lymphomas are a heterogeneous group of cancers with different pathogenesis and poor prognosis. Histone deacetylases (HDACs) are epigenetic modifiers that modulate many key biological processes. In recent years, HDACs have been fully investigated for their roles and potential as drug targets in T-cell lymphomas. Read More

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http://dx.doi.org/10.7150/ijms.30154DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428980PMC
January 2019
7 Reads

Contribution of STAT3 and RAD23B in primary Sézary cells to histone deacetylase inhibitor FK228 resistance.

J Invest Dermatol 2019 Mar 22. Epub 2019 Mar 22.

St. John's Institute of Dermatology, King's College London, Guy's Hospital, London, SE1 9RT, United Kingdom. Electronic address:

FK228 (Romidepsin) and suberoylanilide hydroxamic acid (SAHA, Vorinostat) are FDA-approved histone deacetylase inhibitors (HDACi) for Cutaneous T-cell Lymphoma (CTCL), including the leukemic subtype Sézary Syndrome (SS). This study investigates RAD23B and STAT3 gene perturbations in a large cohort of primary Sézary cells and the effect of FK228 treatment on tyrosine phosphorylation of STAT3 (pYSTAT3) and RAD23B expression. We report RAD23B copy number variation in 10% (12/119; p ≤ 0. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1130DOI Listing
March 2019
1 Read

Subcutaneous Panniculitis-Like T-Cell Lymphoma With Granulomas as the Predominant Feature.

Am J Dermatopathol 2019 Mar 15. Epub 2019 Mar 15.

Department of Dermatopathology, California Skin Institute, San Jose, CA.

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma preferentially localized in the subcutaneous adipose tissue and composed of cytotoxic T cells with an α/β immunophenotype. The neoplastic T cells can be variably admixed with other inflammatory cells, including histiocytes, which can rarely form noncaseating granulomas. We present a case of SPTCL in which granulomas are the predominant feature, composing 75%-80% of the inflammatory infiltrate. Read More

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http://dx.doi.org/10.1097/DAD.0000000000001402DOI Listing
March 2019
4 Reads

Bexarotene-induced hypothyroidism: Characteristics and therapeutic strategies.

Clin Endocrinol (Oxf) 2019 Mar 23. Epub 2019 Mar 23.

Department of Endocrinology and Nephrology, The University of Tokyo School of Medicine, Tokyo, Japan.

Objective: Central hypothyroidism (CH) is a well-known adverse effect of bexarotene treatment for cutaneous T-cell lymphoma (CTCL). While concomitant levothyroxine therapy is recommended in these cases, associations between ethnic variation or susceptibility and bexarotene-induced CH have not yet been reported. This study aimed to characterize the kinetics and dose dependency of bexarotene-induced CH in Japanese patients. Read More

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http://dx.doi.org/10.1111/cen.13975DOI Listing
March 2019
2 Reads

Dosimetric evaluation of electron total skin irradiation using gafchromic film and thermoluminescent dosimetry.

J Cancer Res Ther 2019 Mar;15(Supplement):S115-S122

Department of Medical Radiation, Engineering Faculty, Central Tehran Branch, Islamic Azad University, Tehran, Iran.

Aim Of Study: The aim of this study is to evaluate some dosimetry parameters such as uniformity, surface dose, and max depth dose with thermoluminescent dosimetry (TLD) and EBT3 film in total skin electron beam therapy (TSEBT).

Methods: Stationary and rotary methods were set on Varian linear accelerator, Clinac 2100C. To create a radiation field large enough (168 cm × 60 cm) and uniform, the source skin distance was set 400 cm. Read More

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http://dx.doi.org/10.4103/jcrt.JCRT_1020_16DOI Listing
March 2019
4 Reads

Real-world use of extracorporeal photopheresis for patients with cutaneous T-cell lymphoma in the United States: 2010-2015.

J Dermatolog Treat 2019 Mar 20:1-8. Epub 2019 Mar 20.

a Pharmerit International LP , Bethesda , MA , USA.

Introduction: The National Comprehensive Cancer Network and the European Organization for Research and Treatment of Cancer recommend extracorporeal photopheresis (ECP) as systemic therapy for cutaneous T-cell lymphoma (CTCL).

Objective: To investigate real-world use of ECP in CTCL patients in the US.

Methods: Data from the Truven MarketScan database (2010-2015) were used to create a cohort of CTCL patients receiving systemic treatment. Read More

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http://dx.doi.org/10.1080/09546634.2019.1587144DOI Listing
March 2019
3 Reads

γδ lymphomatoid papulosis type D: A histologic mimic of primary cutaneous γδ T-cell lymphoma.

JAAD Case Rep 2019 Mar 1;5(3):264-266. Epub 2019 Mar 1.

Department of Pathology, University of Michigan, Ann Arbor, Michigan.

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http://dx.doi.org/10.1016/j.jdcr.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6403113PMC
March 2019
2 Reads

Elucidating the mechanism of action of domatinostat (4SC-202) in cutaneous T cell lymphoma cells.

J Hematol Oncol 2019 Mar 18;12(1):30. Epub 2019 Mar 18.

Department of Dermatology, Venereology and Allergology, University Hospital Wuerzburg, Josef-Schneider-Str. 2, 97080, Wuerzburg, Germany.

Background: Targeting epigenetic modifiers is effective in cutaneous T cell lymphoma (CTCL). However, there is a need for further improvement of this therapeutic approach. Here, we compared the mode of action of romidepsin (FK228), an established class I histone deacetylase inhibitor, and domatinostat (4SC-202), a novel inhibitor of class I HDACs, which has been reported to also target the lysine-specific histone demethylase 1A (LSD1). Read More

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http://dx.doi.org/10.1186/s13045-019-0719-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423872PMC
March 2019
2 Reads

Preclinical Targeting of MicroRNA-214 in Cutaneous T-cell Lymphoma (CTCL).

J Invest Dermatol 2019 Mar 12. Epub 2019 Mar 12.

Comprehensive Cancer Center, Ohio State University, Columbus OH United States; Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Sidney Kimmel Cancer Center, Philadelphia, PA; Division of Dermatology, Department of Internal Medicine, Ohio State University, Columbus OH United States. Electronic address:

Cutaneous T-cell lymphomas (CTCL) are a family of primary extranodal lymphomas of mature CD4+, skin-homing or skin-resident T-cells. In a significant fraction of CTCL patients the neoplastic CD4+ lymphocytes acquire extracutaneous tropism, and with disease progression, they disseminate to the lymph nodes, peripheral blood, and visceral organs. MicroRNA (miR)-based therapies are a newly emerging strategy for many types of diseases, including cancers. Read More

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http://dx.doi.org/10.1016/j.jid.2019.01.033DOI Listing
March 2019
5 Reads

Key Role of Reactive Oxygen Species (ROS) in Indirubin Derivative-Induced Cell Death in Cutaneous T-Cell Lymphoma Cells.

Int J Mol Sci 2019 Mar 7;20(5). Epub 2019 Mar 7.

Skin Cancer Centre Charité, Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany.

Cutaneous T-cell lymphoma (CTCL) may develop a highly malignant phenotype in its late phase, and patients may profit from innovative therapies. The plant extract indirubin and its chemical derivatives represent new and promising antitumor strategies. This first report on the effects of an indirubin derivative in CTCL cells shows a strong decrease of cell proliferation and cell viability as well as an induction of apoptosis, suggesting indirubin derivatives for therapy of CTCL. Read More

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http://dx.doi.org/10.3390/ijms20051158DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6429192PMC
March 2019
5 Reads

Developing BET-ter treatments for cutaneous T-cell lymphoma.

Authors:
Henry K Wong

Oncotarget 2019 Feb 12;10(13):1267-1268. Epub 2019 Feb 12.

Henry K. Wong: Department of Dermatology, University of Arkansas for Medical Sciences, Little Rock, AR, USA.

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http://www.oncotarget.com/fulltext/26662
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http://dx.doi.org/10.18632/oncotarget.26662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407685PMC
February 2019
6 Reads
6.359 Impact Factor

Synthesis, Characterization, Quantum-Chemical Calculations and Cytotoxic Activity of 1,8-Naphthalimide Derivatives with non-Protein Amino Acids.

Anticancer Agents Med Chem 2019 Mar 6. Epub 2019 Mar 6.

Department of Chemistry and Chemical Technologies, "Angel Kanchev" University of Ruse, Razgrad Branch, Razgrad 7200. Bulgaria.

Background: The 1,8-Naphthalimides constitute an important class of biologically active, DNA-binding compounds. There are no available data on the synthesis of 1,8-naphthalimide derivatives with non-protein amino acids and their biological activity. The aims of this paper are to synthesis, structural characterization and cytotoxic activity of new 1-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)cycloalkane-1-carboxylic acids with 5-, 6-, 7-, 8- and 12-membered rings as well as 2-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)adamantane-2-carboxylic acid and 1-(1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)-1,2,3,4-tetrahydronaphthalene-1-carboxylic acid. Read More

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http://dx.doi.org/10.2174/1871520619666190307115231DOI Listing
March 2019
7 Reads

The role and contribution of clonality studies in the diagnosis of lymphoproliferative disorders.

Eur J Haematol 2019 Mar 7. Epub 2019 Mar 7.

Haematopathology and Oncology Diagnostics Service, Addenbrooke's Hospital, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.

Objectives: To explore the frequency, context and diagnostic impact of B- and T-lymphocyte clonality assay use in the assessment of possible lymphoproliferative disorders at a central haematopathology diagnostics hub.

Methods: All cases reported by haematopathologists over a sixteen-month period were identified, n = 4462, and those which had clonality studies undertaken analysed further.

Results: Clonality studies were requested in 9% of cases, directly contributing to a diagnosis being made in 79%. Read More

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http://doi.wiley.com/10.1111/ejh.13228
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http://dx.doi.org/10.1111/ejh.13228DOI Listing
March 2019
6 Reads

Challenges of driving CD30-directed CAR-T cells to the clinic.

BMC Cancer 2019 Mar 6;19(1):203. Epub 2019 Mar 6.

Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599, USA.

Chimeric antigen receptor T (CAR-T) cells are a promising new treatment for patients with relapsed or refractory hematologic malignancies, including lymphoma. Given the success of CAR-T cells directed against CD19, new targets are being developed and tested, since not all lymphomas express CD19. CD30 is promising target as it is universally expressed in virtually all classical Hodgkin lymphomas, anaplastic large cell lymphomas, and in a proportion of other lymphoma types, including cutaneous T cell lymphomas and diffuse large B cell lymphomas. Read More

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https://bmccancer.biomedcentral.com/articles/10.1186/s12885-
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http://dx.doi.org/10.1186/s12885-019-5415-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6404322PMC
March 2019
8 Reads

Synthesis and Investigation of Therapeutic Potential of Isoform Specific HDAC8 Inhibitors for The Treatment of Cutaneous T Cell Lymphoma.

Anticancer Agents Med Chem 2019 Mar 1. Epub 2019 Mar 1.

Nuclear Magnetic Resonance Laboratory, School of Chemical & Biotechnology, SASTRA University, Thirumalaisamudram, Thanjavur, Tamilnadu. India.

In recent times, we have reported the design and in silico studies of 52 hydroxamic acid derivatives bearing multi-substituent heteroaromatic rings with chiral amine linker as isoform selective histone deacetylase 8 inhibitors (HDAC8i). Wherein, the report suggested that the presence of chiral amine is a prerequisite to occupy the second binding site of HDAC8. Based on these preliminary results, five compounds were shortlisted and synthesized by microwave assisted approach and high yielding synthetic protocol. Read More

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http://dx.doi.org/10.2174/1871520619666190301150254DOI Listing
March 2019
2 Reads

[Current possibilities of the differential diagnosis of plaque parapsoriasis and the early stages of mycosis fungoides].

Arkh Patol 2019;81(1):9-17

Saint Petersburg State Pediatric Medical University, Ministry of Health of Russia, Saint Petersburg, Russia.

Mycosis fungoides (MF) is the most common primary cutaneous epidermotropic T-cell lymphoma (80%). The accurate diagnosis of MF confirmed only by clinical, histological and immunohistochemical signs amounts to 50-75%.

Objective: To investigate genetic markers (FOXP3, STAT4, IL-12B) for the early diagnosis of MF, to estimate the informative value of used diagnostic techniques (histology, immunophenotyping), and to determine clonality by the T-cell receptor γ-chain genes. Read More

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http://dx.doi.org/10.17116/patol2019810119DOI Listing
January 2019
2 Reads

The Role and Pitfall of F18-FDG PET/CT in Surveillance of High Grade Pulmonary Lymphomatoid Granulomatosis.

Curr Probl Diagn Radiol 2019 Feb 10. Epub 2019 Feb 10.

Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ.

Lymphomatoid granulomatosis (LYG) is an uncommon angiocentric and angiodestructive T-cell rich, Epstein-Barr virus (EBV) positive B-cell multisystem lymphoproliferative disorder, predominately affecting the lungs. Since both clinical presentation and radiographic imaging findings, including X-ray and computed tomographic (CT), are nonspecific, the ultimate diagnosis of LYG relies on lung tissue sample diagnosis with its WHO grading based on the degree of cytologic atypia, necrosis and density of EBV positive B-cells. In addition, its histopathologic grading is correlated with clinical manifestation with high grade LYG mimicking aggressive B-cell lymphoma. Read More

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http://dx.doi.org/10.1067/j.cpradiol.2019.02.002DOI Listing
February 2019

Systemic therapy of cutaneous T-cell lymphoma (CTCL).

Chin Clin Oncol 2019 Feb;8(1):10

Division of Hematologic Malignancies and Hematopoietic Stem Cell Transplantation, Department of Medical Oncology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, PA, USA.

Cutaneous T-cell lymphomas (CTCLs) are a heterogeneous and relatively rare family of extranodal non-Hodgkin's lymphomas (NHL) that are primarily localized to the skin. Most patients present with cutaneous patches, plaques, tumors, more rarely with erythroderma. The type of skin lesions and the surface extent of skin involvement, as well as the presence of extracutaneous disease, are the most important prognostic factors in patients with CTCL. Read More

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http://cco.amegroups.com/article/view/23840/22733
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http://dx.doi.org/10.21037/cco.2019.01.02DOI Listing
February 2019
9 Reads

The histological prevalence and clinical implications of folliculotropism and syringotropism in mycosis fungoides.

Chin Clin Oncol 2019 Feb;8(1)

Department of Dermatology and Cutaneous Biology, Jefferson University Hospital, Philadelphia, PA, USA.

Background: Mycosis fungoides (MF), the most common form of cutaneous T-cell lymphoma, remains a challenge for clinicians to stage and manage. Classically, MF is determined through histopathologic evidence of a neoplastic infiltrate within the epidermis. In certain patients, however, the infiltrate extends into the hair follicles and sweat glands. Read More

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http://cco.amegroups.com/article/view/22933/22725
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http://dx.doi.org/10.21037/cco.2018.10.02DOI Listing
February 2019
6 Reads

Emerging insights on the biology and treatment of cutaneous T-cell lymphoma.

Chin Clin Oncol 2019 Feb;8(1)

Radiation Oncology, Thomas Jefferson University Hospital, Philadelphia, PA, USA.

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http://dx.doi.org/10.21037/cco.2019.01.04DOI Listing
February 2019
1 Read

Management of cutaneous T-cell lymphomas: Established and emergent therapies.

Australas J Dermatol 2019 Feb 26. Epub 2019 Feb 26.

Department of Dermatology, Westmead Hospital, Sydney, New South Wales, Australia.

Cutaneous T-cell lymphoma is an uncommon group of non-Hodgkin's lymphoma primarily affecting the skin. It is comprised of a variety of entities with different clinical behaviours and prognosis. Mycosis fungoides is the commonest subtype, and Sézary syndrome is a much rarer form of cutaneous T-cell lymphoma. Read More

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http://doi.wiley.com/10.1111/ajd.13011
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http://dx.doi.org/10.1111/ajd.13011DOI Listing
February 2019
8 Reads