60 results match your criteria Cutaneous Manifestations of Smoking

Smoking exposure in pack-years predicts cutaneous manifestations and damage in systemic lupus erythematosus.

Lupus 2021 Feb 24:961203321995257. Epub 2021 Feb 24.

Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.

Objective: To examine the impact of cumulative smoking in pack-years on systemic lupus erythematosus (SLE) cutaneous manifestations and damage.

Methods: Our cohort study included 632 adult SLE patients at an academic center, meeting 1997 ACR or 2012 SLICC classification criteria. Outcomes were: (1) cutaneous SLICC Damage Index (SDI), (2) ACR and SLICC criteria. Read More

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February 2021

[Atypical actinomycosis revealed by distant dermatological disorders: Report of an unusual case and literature review].

Rev Med Interne 2021 Mar 7;42(3):210-213. Epub 2020 Dec 7.

Centre de soins dentaires, CHU de Rouen, 2, rue Guillaume-Lecointe, 76140 Le Petit-Quevilly, France.

Introduction: Dermatological manifestations of actinomycosis are classical, most often related to Actinomyces israelii. In most of the cases, they occur near to the primary focus, and in the cervicofacial area. Systemic dissemination with cutaneous distant metastasis is rare, most often related to A. Read More

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Increased Mortality in Asians With Systemic Sclerosis in Northern California.

ACR Open Rheumatol 2020 Apr 21;2(4):197-206. Epub 2020 Mar 21.

Stanford University School of Medicine and Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, California.

Objective: The objective of this study is to evaluate racial/ethnic differences in disease manifestations and survival in a US cohort of patients with systemic sclerosis (SSc), with a focus on Asian patients.

Methods: A retrospective cohort study was conducted among Kaiser Permanente Northern California adults with an incident SSc diagnosis by a rheumatologist from 2007 to 2016, confirmed by a chart review to fulfill 2013 American College of Rheumatology (ACR)/European League Against Rheumatism (EULAR) classification criteria. Self-reported race/ethnicity was categorized as non-Hispanic white, Asian, Hispanic, and black. Read More

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Prediction of Familial Hypercholesterolemia in Patients at High Atherosclerotic Cardiovascular Disease Risk Using a Recently Validated Algorithm.

CJC Open 2019 Jul 7;1(4):190-197. Epub 2019 Jun 7.

McMaster University, Hamilton, Ontario, Canada.

Background: The prevalence of heterozygous familial hypercholesterolemia (FH) is 1 of 250 in the general population and approximately 1 of 125 in patients with atherosclerotic cardiovascular disease (ASCVD), yet only a minority are diagnosed. The diagnostic criteria for FH rely on a point system using low-density lipoprotein cholesterol (LDL-C), family history, cutaneous manifestations, and molecular diagnosis. The aim of the present study was to determine the prevalence of FH in the elating vidence to chieve holesterol argets (REACT) registry. Read More

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Clinic experience in discoid lupus erythematosus: a retrospective study of 132 cases.

Postepy Dermatol Alergol 2019 Dec 21;36(6):739-743. Epub 2018 Aug 21.

Department of Dermatology, Faculty of Medicine, Van Yuzuncu Yil University, Van, Turkey.

Introduction: Lupus erythematosus (LE) is an autoimmune disease characterized by a broad range of cutaneous manifestations. Discoid LE (DLE) is the most common chronic manifestation of LE. Literature reviews show that there are a limited number of large-series studies investigating DLE. Read More

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December 2019

Tobacco smoking is an independent factor associated with retinal damage in systemic lupus erythematosus: a cross-sectional and retrospective study.

Rheumatol Int 2020 Mar 27;40(3):367-374. Epub 2019 Nov 27.

Rheumatology Service, Hospital Universitario de Gran Canaria Doctor Negrin, Las Palmas, GC, Spain.

To analyze the influence of tobacco smoking on systemic lupus erythematosus (SLE) clinical features and damage. Cross-sectional and retrospective, case-control study comparing SLE patients with and without tobacco exposure. Cumulative clinical data and comorbidities were collected, and severity (Katz index) and damage (SLICC/ACR damage index) (SDI) indices were calculated. Read More

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Management of cutaneous manifestations of lupus erythematosus: A systematic review.

Semin Arthritis Rheum 2020 02 12;50(1):95-127. Epub 2019 Aug 12.

Department of Rheumatology, St Vincent's Hospital, Melbourne, Australia; The University of Melbourne, Australia. Electronic address:

Background: Cutaneous lupus erythematosus (CLE), occurring with or without systemic lupus erythematosus (SLE), is a group of inflammatory skin diseases that can be very debilitating, causing significant psychological distress, and sometimes scarring.

Objectives: We sought to comprehensively present the evidence for different treatment modalities in patients with cutaneous manifestations of lupus erythematosus (LE).

Methods: Medline, Embase, Scopus and Cochrane CENTRAL were searched electronically from 1990 to March 2019, using keywords related to cutaneous lupus and synonyms and treatment. Read More

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February 2020

Impact of tobacco smoking upon disease risk, activity and therapeutic response in systemic lupus erythematosus: A systematic review and meta-analysis.

Autoimmun Rev 2019 Nov 11;18(11):102393. Epub 2019 Sep 11.

Service de rhumatologie, Hôpitaux Universitaires de Strasbourg, Centre National de Référence des Maladies Systémiques Rares Est Sud-Ouest (RESO), Université de Strasbourg, F-67000 Strasbourg, France. Electronic address:

Systemic lupus erythematosus (SLE) is a complex disease with variable presentations, course and prognosis. Published studies present conflicting data regarding the impact of cigarette smoking on SLE risk, disease activity, clinical manifestations and treatment response. We performed a comprehensive literature search using Medline, EMBASE and the Cochrane Collaboration database, and hand searches of relevant bibliographies. Read More

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November 2019

Occurrence of skin manifestations in patients of the Swiss Inflammatory Bowel Disease Cohort Study.

PLoS One 2019 25;14(1):e0210436. Epub 2019 Jan 25.

Department of Gastroenterology and Hepatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Background/aims: Extraintestinal cutaneous manifestations of IBD represent a severe disease complication and an early and accurate treatment might positively influence the disease course. Using the patient collective of the Swiss IBD Cohort Study (SIBDCS), we analysed epidemiological as well as clinical factors being associated with the onset of pyoderma gangrenosum, erythema nodosum and aphthous ulcers in IBD patients.

Methods: We included 3266 SIBDCs patients, 1840 with Crohn's disease (CD) and 1426 with ulcerative colitis (UC) or IBD unclassified (IBDU) and analysed the association of cutaneous manifestations with age, age at diagnosis time, type of disease, gender, family history, HLA-allotype, smoking, intestinal disease activity, therapy and other extraintestinal manifestations (EIM). Read More

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November 2019

Porphyria cutanea tarda and hepatoerythropoietic porphyria: Identification of 19 novel uroporphyrinogen III decarboxylase mutations.

Mol Genet Metab 2019 11 28;128(3):363-366. Epub 2018 Nov 28.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Porphyria Cutanea Tarda (PCT) is a cutaneous porphyria that results from the hepatic inhibition of the heme biosynthetic enzyme uroporphyrinogen decarboxylase (UROD), and can occur either in the absence or presence of an inherited heterozygous UROD mutation (PCT subtypes 1 and 2, respectively). A heterozygous UROD mutation causes half-normal levels of UROD activity systemically, which is a susceptibility factor but is not sufficient alone to cause type 2 PCT. In both Types 1 and 2 PCT, the cutaneous manifestations are precipitated by additional factors that lead to generation of an inhibitor that more profoundly reduces hepatic UROD activity. Read More

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November 2019

Smoking reduces the efficacy of belimumab in mucocutaneous lupus.

Expert Opin Biol Ther 2018 08 9;18(8):911-920. Epub 2018 Jul 9.

a Division of Rheumatology, Department of Medicine , Karolinska Institutet , Stockholm , Sweden.

Objectives: Recently, we demonstrated a negative impact of smoking on belimumab efficacy in patients with systemic lupus erythematosus (SLE). Here, we particularly investigated clinical effects of belimumab and a potential impact of smoking in mucocutaneous and articular SLE.

Methods: We surveyed 62 SLE patients treated between 2011 and 2017. Read More

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Brief Report: Smoking in Systemic Sclerosis: A Longitudinal European Scleroderma Trials and Research Group Study.

Arthritis Rheumatol 2018 11 24;70(11):1829-1834. Epub 2018 Sep 24.

University Hospital Basel, Basel, Switzerland.

Objective: Data on the role of tobacco exposure in systemic sclerosis (SSc; scleroderma) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations, based on the European Scleroderma Trials and Research group database.

Methods: Adult SSc patients with data on smoking history and a 12-24-month follow-up visit were included. Read More

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November 2018

Disease severity and prophylactic measures in patients with cutaneous lupus erythematosus: results of a worldwide questionnaire-based study.

Postepy Dermatol Alergol 2018 Apr 24;35(2):192-198. Epub 2018 Apr 24.

Department of Dermatology, University of Rzeszow, Rzeszow, Poland.

Introduction: Due to a wide array of dermatologic manifestations, assessment of disease severity in cutaneous lupus erythematosus (CLE) remains challenging. Given a need for some standardization in this field, we conducted a worldwide questionnaire-based study among physicians experienced in CLE management.

Aim: We asked about CLE assessment, their prophylactic measures advised to patients, and treatment recommendations. Read More

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Cutaneous and Mucosal Manifestations of Sjögren's Syndrome.

Clin Rev Allergy Immunol 2017 Dec;53(3):357-370

Division of Rheumatology and Clinical Immunology, Humanitas Research Hospital, Via A. Manzoni 56, 20089 Rozzano, Milan, Italy.

Sjögren's syndrome is currently considered an "autoimmune epithelitis," as exocrine glands, especially salivary and lacrimal, are progressively destructed by an immune-mediated process associated with specific serum autoantibodies and local lymphocyte infiltrate. Xerostomia remains a key complain in patients with Sjögren's syndrome but should be evaluated also for other causes such as xerogenic medications, followed by radiation and chemotherapy for head and neck cancers, hormone disorders, infections, or other connective tissue diseases. Further, xerophtalmia (also known as dry eye) frequently associated with keratoconjunctivitis sicca cumulatively affects approximately 10-30% of the general population with increasing incidence with age and is more frequently secondary to non-autoimmune diseases. Read More

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December 2017

Generalized Discoid Lupus Erythematosus as the Presenting Sign of Small Cell Lung Carcinoma.

Skinmed 2017;15(3):218-220. Epub 2017 Jun 1.

Department of Dermatology, Mayo Clinic, Rochester, MN.

A 46-year-old woman with a 30 pack-year smoking history presented with a worsening eruption on the left cheek that failed to improve with metronidazole gel. The cutaneous eruption spread to most of her face and did not respond to a brief tapering course of prednisone. During the initial evaluation at our institution, approximately 6 weeks after the onset of the cutaneous eruption, the patient had erythematous, crusted plaques on her face and scalp (Figure 1A); they were also present on the V-area of the anterior aspect of the neck and upper region of the chest, the shoulders, and the arms, with isolated lesions on the trunk and legs. Read More

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Hepatic porphyria: A narrative review.

Indian J Gastroenterol 2016 Nov 31;35(6):405-418. Epub 2016 Oct 31.

Department of Internal Medicine, UAB University of Alabama in Birmingham, Birmingham, AL, USA.

Porphyrias are a group of metabolic disorders, which result from a specific abnormality in one of the eight enzymes of the heme biosynthetic pathway. These have been subdivided based on the predominant site of enzyme defect into hepatic and erythropoietic types and based on clinical presentation into acute neurovisceral and cutaneous blistering porphyrias. This review focuses on hepatic porphyrias, which include acute intermittent porphyria (AIP), variegate porphyria (VP), hereditary coproporphyria (HCP), aminolevulinic acid dehydratase deficiency porphyria (ADP), and porphyria cutanea tarda (PCT). Read More

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November 2016

The relationship between vascular biomarkers and disease characteristics in systemic sclerosis: elevated MCP-1 is predominantly associated with fibrotic manifestations.

Clin Exp Rheumatol 2016 Sep-Oct;34 Suppl 100(5):110-114. Epub 2016 Oct 14.

Division of Rheumatology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Turkey.

Objectives: To determine the relationship between vascular biomarkers reflecting the vascular injury and organ involvement in systemic sclerosis (SSc).

Methods: Seventy-two SSc patients (66 female) fulfilling 2013 ACR/EULAR Criteria were evaluated. Serum samples of patients were collected for flow-cytometric analysis of sCD40L, tPA, MCP-1, sE-selectin, IL-8, IL-6, VEGF, sP-selectin, TGF-β1 and VCAM levels (Bender MedSystems) in SSc patients and 20 healthy controls. Read More

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January 2017

Hydradenitis suppurativa and inflammatory bowel disease: An unusual, but existing association.

World J Gastroenterol 2016 May;22(20):4802-11

Mariabeatrice Principi, Antonella Contaldo, Andrea Iannone, Giuseppe Losurdo, Michele Barone, Enzo Ierardi, Alfredo Di Leo, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, 70124 Bari, Italy.

Inflammatory bowel disease (IBD) could be associated with several extra-intestinal manifestations (EIMs) involving musculoskeletal, hepatopancreatobiliary, ocular, renal, and pulmonary systems, as well as the skin. In the last years, hidradenitis suppurativa (HS) is acquiring an increasing interest. IBD, especially Crohn's disease (CD), is among the most reported associated diseases in HS patients. Read More

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[Cutaneous lupus erythematosus].

Ugeskr Laeger 2015 Jul;177(31)

Sdr. Boulevard 59, 2. th., 5000 Odense C.

Cutaneous lupus erythematosus (LE) is an autoimmune disease. The most common clinical forms are acute cutaneous LE (ACLE), subacute cutaneous LE (SCLE) and discoid LE (DLE). Cutaneous LE, mainly ACLE, can be the first sign of systemic LE (SLE). Read More

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Expert Opin Orphan Drugs 2014 Jun;2(6):567-577

PXE International, Washington, DC.

Introduction: Pseudoxanthoma elasticum (PXE), a multisystem orphan disease, clinically affects the skin, the eyes, and the cardiovascular system with considerable morbidity and mortality. The clinical manifestations reflect the underlying pathology consisting of ectopic mineralization of peripheral connective tissues.

Areas Covered: The diagnostic criteria of PXE include characteristic clinical findings, together with histopathology of accumulation of pleiomorphic elastic structures in the dermis with progressive mineralization, and the presence of mutations in the gene. Read More

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Extraintestinal manifestations of inflammatory bowel disease and the influence of smoking.

Digestion 2014 1;90(2):122-9. Epub 2014 Oct 1.

Department of Surgery, Price Institute of Surgical Research and Section of Colorectal Surgery, University of Louisville School of Medicine, Louisville, Ky., USA.

Aims: To define the number/frequency of organ systems affected by extraintestinal manifestations (EIMs), to identify factors affecting the clinical course of inflammatory bowel disease (IBD) and EIM development, and to determine the impact of smoking, disease duration and location on the diagnosis of EIMs in Crohn's disease (CD) and ulcerative colitis (UC).

Methods: IBD patients were derived from a single university colorectal surgery practice. Smoking data were obtained through a modified Behavioral Risk Factor Surveillance System survey. Read More

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Environmental factors in benign migratory glossitis and psoriasis: retrospective study of the association of emotional stress and alcohol and tobacco consumption with benign migratory glossitis and cutaneous psoriasis.

J Eur Acad Dermatol Venereol 2015 Mar 30;29(3):533-6. Epub 2014 Jul 30.

Discipline of Dermatology, Medical School, University of Marília (UNIMAR), Marília, SP, Brazil; Beneficent Association of the University Hospital of Unimar (ABHU), Marília, São Paulo, Brazil.

Background: The association between benign migratory glossitis (BMG) and psoriasis (PS) has been reported in the literature.

Objective: This study aimed to determinate the environmental factors related to BMG and PS and to investigate their interactions.

Methods: The study population included 129 patients with PS, 399 patients with BMG and a control group (CG) of 5472 individuals with neither PS nor BMG. Read More

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Characteristics, prognosis, and outcomes of cutaneous ischemia and gangrene in systemic necrotizing vasculitides: a retrospective multicenter study.

Semin Arthritis Rheum 2014 Apr 9;43(5):681-8. Epub 2013 Oct 9.

Department of Internal Medicine, National Referral Center for Rare Systemic and Autoimmune Diseases, Hôpital Cochin, Assistance Publique-Hôpitaux de Paris, Université Paris Descartes, Paris, France; Department of Rheumatology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada.

Objectives: To describe the prevalence, characteristics, and outcome of cutaneous ischemia, and whether it can occur in systemic necrotizing vasculitides (SNVs), i.e., polyarteritis nodosa, granulomatosis with polyangiitis, and eosinophilic granulomatosis with polyangiitis and microscopic polyangiitis. Read More

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Predictive factors for erythema nodosum and pyoderma gangrenosum in inflammatory bowel disease.

J Gastroenterol Hepatol 2014 Feb;29(2):291-5

Unit for Clinical Management of Digestive Diseases, Valme University Hospital, Sevilla, Spain.

Background And Aim: To identify predictive factors related to the development of erythema nodosum and pyoderma gangrenosum, in patients with inflammatory bowel disease (IBD).

Methods: Epidemiological and clinical data from 270 patients with Crohn's disease (CD) and 125 patients with ulcerative colitis (UC) were collected between 2003 and 2011. The variables retrospectively analyzed were: gender, age at diagnosis, type of IBD (CD or UC), smoking habit, pattern of disease (IBD), location and extension, family history, previous IBD-related surgery, other extraintestinal manifestations (EIMs), and previous biological and immunosuppressive therapy. Read More

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February 2014

Psoriasis outcome measures: a report from the GRAPPA 2012 annual meeting.

J Rheumatol 2013 Aug;40(8):1428-33

Department of Dermatology, Tufts Medical Center, Boston, Massachusetts 02111-1533, USA.

Psoriasis is a multisystem disease. The cutaneous and musculoskeletal manifestations (psoriatic arthritis) are well recognized. However, the other manifestations of psoriatic disease including metabolic syndrome, atherosclerotic cardiovascular disease, depression, poor self-esteem, and self-destructive habits including obesity, smoking and excess alcohol consumption are underappreciated. Read More

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[Cutaneous lupus erythematosus and skin manifestations in systemic lupus erythematosus].

M Sticherling

Z Rheumatol 2013 Jun;72(5):429-35

Hautklinik, Universitätsklinikum Erlangen, Ulmenweg 18, 91054, Erlangen, Deutschland.

Skin manifestations are frequently observed in lupus erythematosus (LE) and are manifold. Nonspecific and specific symptoms can be differentiated with the latter belonging to the dermatologically well-characterized clinical entities of acute cutaneous, subacute cutaneous, chronic cutaneous as well as intermittent cutaneous LE. These forms are differentially related to systemic LE. Read More

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