473 results match your criteria Cutaneous Manifestations of HIV Disease


Unusual Clinical Manifestations of in an HIV-coinfected Patient and the Relevance of ITS1-PCR-RFLP: A Case Report.

Iran J Parasitol 2018 Oct-Dec;13(4):655-660

Laboratory of Parasitology, Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.

Patients coinfected with /HIV can develop atypical forms of visceral leishmaniasis (VL), making it indispensable to identify the etiological agent. We are presenting a post-mortem specie definition by ITS1-PCR-RFLP in a larynx tissue of a patient presented coinfection /HIV. This patient was from a leishmaniasis endemic region in São Paulo (SP), Brazil, and was diagnosed clinically with mucocutaneous leishmaniasis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348215PMC
January 2019
1 Read

Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.

mSphere 2018 12 12;3(6). Epub 2018 Dec 12.

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA.

Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV). Read More

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http://msphere.asm.org/lookup/doi/10.1128/mSphereDirect.0064
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http://dx.doi.org/10.1128/mSphereDirect.00645-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291628PMC
December 2018
14 Reads

Porphyria cutanea tarda and hepatoerythropoietic porphyria: Identification of 19 novel uroporphyrinogen III decarboxylase mutations.

Mol Genet Metab 2018 Nov 28. Epub 2018 Nov 28.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Porphyria Cutanea Tarda (PCT) is a cutaneous porphyria that results from the hepatic inhibition of the heme biosynthetic enzyme uroporphyrinogen decarboxylase (UROD), and can occur either in the absence or presence of an inherited heterozygous UROD mutation (PCT subtypes 1 and 2, respectively). A heterozygous UROD mutation causes half-normal levels of UROD activity systemically, which is a susceptibility factor but is not sufficient alone to cause type 2 PCT. In both Types 1 and 2 PCT, the cutaneous manifestations are precipitated by additional factors that lead to generation of an inhibitor that more profoundly reduces hepatic UROD activity. Read More

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http://dx.doi.org/10.1016/j.ymgme.2018.11.013DOI Listing
November 2018
3 Reads

Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa-A systematic review.

PLoS Negl Trop Dis 2018 10 25;12(10):e0006914. Epub 2018 Oct 25.

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Introduction: Cutaneous leishmaniasis (CL) is the most frequent form of leishmaniasis, with 0.7 to 1.2 million cases per year globally. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006914
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http://dx.doi.org/10.1371/journal.pntd.0006914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219817PMC
October 2018
5 Reads

Basidiobolomycosis in Togo: clinico-pathological study of a series of 12 presumed cases.

BMC Res Notes 2018 Sep 14;11(1):667. Epub 2018 Sep 14.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.

Objective: The purpose of our study was to describe the histological diagnosed of the Basidiobolomycosis cases from 1990 to 2017 (28 years) in the only Pathology Anatomy Laboratory in Togo.

Results: A total of 12 cases of suspected Basidiobolomycosis have been identified. The sex ratio (M/F) was 2. Read More

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http://dx.doi.org/10.1186/s13104-018-3777-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137730PMC
September 2018
2 Reads

Epidemiological and Clinical Patterns of Kaposi Sarcoma: A 16-Year Retrospective Cross-Sectional Study from Yaoundé, Cameroon.

Dermatology 2018 11;234(5-6):198-204. Epub 2018 Sep 11.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: The burden of Kaposi sarcoma (KS) is increasing fast among HIV-infected populations, but the disease remains desperately underexplored in Cameroon, where the burden of HIV is high.

Methods: This is a retrospective cross-sectional study carried out over a period of 16 years (January 2001 to December 2016) at the HIV day care unit of the Central Hospital of Yaoundé, Cameroon. The diagnosis was based on clinical aspects and histological confirmation, and we used a preconstructed questionnaire for data collection through patients' electronic and physical files. Read More

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http://dx.doi.org/10.1159/000492175DOI Listing
September 2018
6 Reads

A study of clinicopathological correlation of pruritic papular eruptions in HIV patients.

Indian J Sex Transm Dis AIDS 2018 Jan-Jun;39(1):44-49

Department of Skin and VD, Rajindra Hospital, GMC, Patiala, Punjab, India.

Context: Pruritic papular eruption (PPE) is a chronic eruption of papular and pruritic lesions of unknown etiology, symmetrically distributed over trunk and extremities. These are common cutaneous manifestations in HIV patients. It is an important cause of HIV-related morbidity. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_10_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111639PMC
September 2018
2 Reads

Non-cutaneous AIDS-associated Kaposi's sarcoma presenting as recurrent rectal abscesses.

BMJ Case Rep 2018 Aug 20;2018. Epub 2018 Aug 20.

Department of Surgery, NYU Langone Hospital-Brooklyn, Brooklyn, New York, USA.

Kaposi's sarcoma is a fatal disease that typically presents with cutaneous manifestations in immunocompromised individuals. There are a small number of documented cases where patients diagnosed with this disease present without cutaneous lesions. We present a 35-year-old man with recurrent rectal abscesses and fistula-in-ano, which required multiple drainage procedures. Read More

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http://dx.doi.org/10.1136/bcr-2018-225749DOI Listing
August 2018
21 Reads

Kaposi's sarcoma in persons living with HIV/AIDS: a case series in a tertiary referral hospital.

An Bras Dermatol 2018 Jul-Aug;93(4):524-528

Pathology Department, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém (PA), Brazil.

Background: Kaposi's sarcoma (KS) is a rare neoplasm with indolent progression. Since 1981, the Kaposi's sarcoma epidemic has increased as co-infection with HIV.

Objectives: The study aimed to identify the clinical and demographic characteristics and therapeutic approaches in HIV/AIDS patients in a regional referral hospital. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20186978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063130PMC
September 2018
3 Reads

[A rare and atypical cause of scrotal ulcerations].

Pan Afr Med J 2018 30;29:87. Epub 2018 Jan 30.

Service de Dermatologie-Vénéréologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Salmonelloses are bacterial infections of the faecal peril; they are endemic in some regions of the world. They can colonize almost any organ hematogenously, hence, severe forms may be observed. We report a case of typhoid fever in a 16-year old young adolescent with no medical history, sexually transmitted diseases or sexual intercourses, presenting with necrotic scrotal ulcerations evolving over the past 3 weeks in a context of fever, diarrhoea, weight loss and alteration of the general state. Read More

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http://dx.doi.org/10.11604/pamj.2018.29.87.14511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987151PMC
June 2018
5 Reads

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review.

Clin Drug Investig 2018 Aug;38(8):653-671

Department of Clinical Experimental Oncology, Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.

The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases. Indeed, they have anti-inflammatory, immunomodulating, anti-infective, antithrombotic, and metabolic effects. Read More

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http://link.springer.com/10.1007/s40261-018-0656-y
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http://dx.doi.org/10.1007/s40261-018-0656-yDOI Listing
August 2018
10 Reads

Real-time PCR applications for diagnosis of leishmaniasis.

Parasit Vectors 2018 05 2;11(1):273. Epub 2018 May 2.

Department of Biomolecular Sciences, University of Urbino Carlo Bo, via Saffi 2, 61029, Urbino, PU, Italy.

Leishmaniasis is a vector-borne disease caused by many Leishmania species, which can infect both humans and other mammals. Leishmaniasis is a complex disease, with heterogeneous clinical manifestations ranging from asymptomatic infections to lesions at cutaneous sites (cutaneous leishmaniasis), mucosal sites (mucocutaneous leishmaniasis) or in visceral organs (visceral leishmaniasis), depending on the species and host characteristics. Often, symptoms are inconclusive and leishmaniasis can be confused with other co-endemic diseases. Read More

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http://dx.doi.org/10.1186/s13071-018-2859-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930967PMC
May 2018
3 Reads

Non-primary nail-plate syphilis in an HIV-infected patient.

SAGE Open Med Case Rep 2018 28;6:2050313X18767229. Epub 2018 Mar 28.

Infectious Disease Clinic, Department of Medicine, University of Perugia, Perugia, Italy.

A 37-year-old Caucasian male, HIV-infected (CDC A2) in 2012 and on antiretroviral therapy, presented for a follow-up visit. On physical examination, a barely discernible light-colored macular rash was observed on the trunk, not involving the palms and soles. However, clear maculo-papular lesions were present over the proximal volar aspect of both forearms. Read More

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http://dx.doi.org/10.1177/2050313X18767229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881977PMC
March 2018
4 Reads

[The changing face of medium-sized vasculitis].

Wiad Lek 2018;71(1 pt 1):64-72

Studia Doktoranckie, Zakład Farmakologii, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny, Lublin.

Polyarteritis nodosa is a systemic necrotizing vasculitis which predominantly affects medium-sized arteries. It is a rare disease nowadays. Both the nomenclature and the classification of polyarteritis nodosa was amended several times in the past. Read More

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August 2018
5 Reads

Tegumentary leishmaniasis and coinfections other than HIV.

PLoS Negl Trop Dis 2018 03 1;12(3):e0006125. Epub 2018 Mar 1.

Department of Public Health, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.

Background: Tegumentary leishmaniasis (TL) is a disease of skin and/or mucosal tissues caused by Leishmania parasites. TL patients may concurrently carry other pathogens, which may influence the clinical outcome of TL.

Methodology And Principal Findings: This review focuses on the frequency of TL coinfections in human populations, interactions between Leishmania and other pathogens in animal models and human subjects, and implications of TL coinfections for clinical practice. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832191PMC
March 2018
5 Reads

Secondary pulmonary syphilis: Case report and review of literature.

Ann Dermatol Venereol 2018 Apr 17;145(4):278-287. Epub 2018 Feb 17.

Service de dermatologie, hôpital Emile-Muller, GHR Mulhouse-Sud Alsace, 20, avenue du Dr-René-Laennec, 68100 Mulhouse, France.

Introduction: Syphilis is a sexually transmitted disease that can affect numerous organs in its secondary or tertiary stages. We describe a case of secondary syphilis with pulmonary involvement and we present a literature review.

Patients And Methods: A 69-year-old male patient was admitted to hospital for dyspnoea and extended papular exanthema with palmoplantar involvement. Read More

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http://dx.doi.org/10.1016/j.annder.2017.11.015DOI Listing
April 2018
2 Reads

Mucocutaneous Manifestations of Infection by Histoplasma capsulatum in HIV-Negative Immunosuppressed Patients.

Actas Dermosifiliogr 2018 May 9;109(4):e27-e32. Epub 2018 Feb 9.

Servicio de Dermatología, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Histoplasmosis is a systemic mycosis caused by the dimorphous fungus Histoplasma capsulatum (H. capsulatum). The fungus enters the body through the respiratory tract in the form of microconidia, which are transformed into intracellular yeast-like structures in the lungs before disseminating hematogenously. Read More

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http://dx.doi.org/10.1016/j.ad.2017.08.006DOI Listing
May 2018
1 Read

Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.

J Fungi (Basel) 2017 Feb 10;3(1). Epub 2017 Feb 10.

Dermatology Service, Mycology Department, Hospital General de México "Eduardo Liceaga", Balmis 148, Colonia Doctores, CP: 03020. Cd. de México, México.

Sporotrichosis is an implantation or inoculation mycosis caused by species of complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are () and . Read More

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http://dx.doi.org/10.3390/jof3010006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715962PMC
February 2017
3 Reads

Correlation of mucocutaneous manifestations of HIV-infected patients in an ART center with CD4 counts.

Indian J Dent Res 2017 Sep-Oct;28(5):549-554

Department of Oral and Maxillofacial Pathology, Vokkaligara Sangha Dental College, Bengaluru, Karnataka, India.

Background: As the search for reliable clinical indicators for management of human immunodeficiency virus/AIDS continues, mucocutaneous manifestations of HIV are considered among key clinical indicators for prediction of underlying degree of immunosuppression, systemic opportunistic infections, and disease progression.

Objectives: (1) To study the prevalence of mucocutaneous manifestations in HIV-seropositive patients attending the ART center of our hospital (2) To correlate mucocutaneous manifestations with CD4 cell counts.

Materials And Methods: A total of 200 HIV-seropositive patients of adult age group visiting our hospital were included in the study. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_352_16DOI Listing
July 2018
2 Reads

Adrenal incidentaloma in a patient with HIV/AIDS.

J Surg Case Rep 2017 Jul 7;2017(7):rjx125. Epub 2017 Jul 7.

Department of General Surgery, Queen Elizabeth University Hospital, Glasgow, UK.

Human immunodeficiency virus (HIV) is well known to be associated with various neoplasms and opportunistic infections. Kaposi sarcoma (KS), associated with human herpes virus 8 (HHV8) infection, is the most common tumour in HIV positive patients and is also an acquired immune deficiency syndrome (AIDS) defining illness. Cutaneous manifestations are the most common presenting symptom; however, visceral involvement is also recognized. Read More

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http://dx.doi.org/10.1093/jscr/rjx125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570053PMC
July 2017
2 Reads

Histoplasmosis by var. duboisii Observed at the Laboratory of Pathological Anatomy of Lomé in Togo.

J Pathog 2017 18;2017:2323412. Epub 2017 Jul 18.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.

Our study aimed to describe the epidemiological, clinical, and diagnostic aspects of African histoplasmosis in Togo through a descriptive and cross-sectional study on histological diagnosed African histoplasmosis in Pathology Department of Lomé from 2002 to 2016 (15 years). A total of 17 cases of African histoplasmosis were diagnosed. The sex ratio (M/F) was 1. Read More

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http://dx.doi.org/10.1155/2017/2323412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539941PMC
July 2017
59 Reads

Correlation of CD4 counts with clinical and histopathological findings in disseminated histoplasmosis: a 10-year retrospective study.

Int J Dermatol 2017 Sep 5;56(9):926-931. Epub 2017 Jul 5.

Department of Dermatovenerology, Medical Faculty Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Disseminated cutaneous histoplasmosis (DCH) is one of the manifestations of systemic histoplasmosis infection in HIV-positive patients. Interaction between host immune status and histoplasmosis infection is still poorly understood. It is thought that immune status, represented by CD4 counts, may be correlated with clinical and histopathological findings. Read More

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http://dx.doi.org/10.1111/ijd.13679DOI Listing
September 2017
8 Reads

Approach to skin and soft tissue infections in non-HIV immunocompromised hosts.

Curr Opin Infect Dis 2017 Aug;30(4):354-363

Section of Infectious Diseases and HIV Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Purpose Of Review: Skin and soft tissue infections are frequent contributors to morbidity and mortality in the immunocompromised host. This article reviews the changing epidemiology and clinical manifestations of the most common cutaneous pathogens in non-HIV immunocompromised hosts, including patients with solid organ transplants, stem cell transplants, solid tumors, hematologic malignancies, and receiving chronic immunosuppressive therapy for inflammatory disorders.

Recent Findings: Defects in the innate or adaptive immune response can predispose the immunocompromised host to certain cutaneous infections in a predictive fashion. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000378DOI Listing
August 2017
5 Reads

Unusual presentation of disseminated histoplasmosis in an immunocompetent patient.

Diagn Cytopathol 2017 Sep 4;45(9):848-850. Epub 2017 May 4.

Department of pathology, PGIMER, Dr. RML Hospital, New Delhi, India.

Disseminated histoplasmosis (DH) is a systemic granulomatous disease caused by the fungus Histoplasma capsulatum. This disease occurs mainly in immunocompromised individuals with CD 4 counts less than 200 cell/µL and is rarely noted in immunocompetent person. In India, this disease has been reported from several parts of the country of which most cases are from eastern India which is considered to be endemic for this disease. Read More

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http://dx.doi.org/10.1002/dc.23742DOI Listing
September 2017
4 Reads

Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy - a case report.

BMC Infect Dis 2017 04 26;17(1):311. Epub 2017 Apr 26.

Department of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Background: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans and most remarkably manifests in HIV-infected individuals, especially in the settings of very low CD4 count. Development of cryptococcosis in HIV-uninfected individuals is exceedingly rare and usually signifies a marked immunodeficiency. Cryptococcosis in association with myasthenia gravis or thymoma has been previously documented in only very few cases in the literature. Read More

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http://dx.doi.org/10.1186/s12879-017-2415-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406963PMC
April 2017
23 Reads

The Great Impostor: Transaminitis Masking the Coinfection of Syphilis and Human Immunodeficiency Virus.

Case Rep Med 2017 19;2017:2481961. Epub 2017 Mar 19.

St. John Providence Southfield Hospital, Southfield, MI, USA.

. The incidence of syphilis continues to rise in the United States over the past 15 years. This disease process is classified into stages and may present with a coinfection of Human Immunodeficiency Virus (HIV). Read More

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http://dx.doi.org/10.1155/2017/2481961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376408PMC
March 2017
7 Reads

Discoid Lupus and Human Immunodeficiency Virus: A Retrospective Chart Review to Determine the Prevalence and Progression of Co-occurrence of these Conditions at a Single Academic Center.

Indian J Dermatol 2017 Mar-Apr;62(2):226

Department of Dermatology, University of California, San Diego, CA, USA.

Context: Discoid lupus erythematosus (DLE) and human immunodeficiency virus (HIV) are both disorders of the immune system. The pathophysiology of these diseases varies greatly as DLE is characterized by an overactive immune system that attacks normal host cells, whereas HIV is characterized by an exogenous attack on the immune system that depletes it of key cell types. Although the reason is unknown, co-occurrence of DLE and HIV is rare. Read More

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http://dx.doi.org/10.4103/0019-5154.201750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363158PMC
April 2017
13 Reads

Cutaneous manifestations of subcutaneous and systemic fungal infections in tropical regions: a retrospective study from a referral center in southern Taiwan.

Int J Dermatol 2017 Jun 13;56(6):623-629. Epub 2017 Mar 13.

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Deep cutaneous fungal infections, including subcutaneous mycoses and systemic fungal infection with cutaneous involvement, cause significant morbidity and mortality in light of increasing immunocompromised patients and global warming. Although a few studies reviewed deep fungal infections in temperate regions, a relevant study in tropical regions is lacking. We evaluated features of deep cutaneous fungal infections in southern Taiwan among the tropical regions. Read More

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http://dx.doi.org/10.1111/ijd.13497DOI Listing
June 2017
14 Reads

Acquired Immune Deficiency Syndrome-Associated Kaposi Sarcoma in a Child Presenting as a Solitary Plantar Hyperkeratotic Plaque.

J Cutan Med Surg 2017 Jul/Aug;21(4):348-350. Epub 2017 Mar 13.

1 Division of Dermatology, CHU de Quebec, Quebec, QC, Canada.

Background And Objective: Acquired immune deficiency syndrome (AIDS)-associated Kaposi sarcoma (KS) among the pediatric population is a rare entity in North America and Europe, and its cutaneous manifestations are not well defined in the literature. The investigators report the case of a boy with an AIDS-associated KS presenting as an infiltrated hyperkeratotic plaque of the plantar arch.

Methods And Results: An 11-year-old African boy with congenital human immunodeficiency virus (HIV) had a skin biopsy of the plantar lesion that was consistent with a KS. Read More

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http://dx.doi.org/10.1177/1203475417698696DOI Listing
May 2018
9 Reads

Case report of three consecutive lues maligna infections in an HIV-infected patient.

Int J STD AIDS 2017 04 10;28(5):523-525. Epub 2016 Oct 10.

Medizinische Klinik und Poliklinik IV, Section Infectious Diseases, Klinikum der Universität München, Munich, Germany.

Lues maligna is a rare presentation of an infection with Treponema pallidum. Here we report three lues maligna infections with severe dermatological manifestations in a single HIV-1 infected individual. Despite the start of highly active antiretroviral therapy and a substantial increase in CD4 cell count after the first episode, he developed consecutive episodes. Read More

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http://dx.doi.org/10.1177/0956462416674102DOI Listing
April 2017
10 Reads

Endoscopic Appearance of Oropharyngeal and Upper GI Kaposi's Sarcoma in an Immunocompromised Patient.

Case Rep Gastrointest Med 2017 5;2017:3742684. Epub 2017 Feb 5.

University of Toledo Medical Center, Toledo, OH, USA.

. Kaposi's sarcoma (KS) usually manifests as a cutaneous disease but GI manifestation is often rare. It is associated with human herpes virus-8 (HHV-8) and seen in immunocompromised patients. Read More

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http://dx.doi.org/10.1155/2017/3742684DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316429PMC
February 2017
5 Reads

Unmasking histoplasmosis immune reconstitution inflammatory syndrome in a patient recently started on antiretroviral therapy.

Autops Case Rep 2016 Oct-Dec;6(4):27-33. Epub 2016 Dec 30.

College of Health Sciences - School of Biomedical Sciences - Makerere University, Kampala - Uganda .

Histoplasmosis is the most common endemic mycoses among HIV-infected people. Patients with suppressed cell immunity mainly due to HIV are at increased risk of disseminated disease. Dermatological manifestations of immune reconstitution inflammatory syndrome (IRIS) and cutaneous manifestations of histoplasmosis similar to an IRIS event have been previously described. Read More

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http://dx.doi.org/10.4322/acr.2016.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5304559PMC
December 2016
18 Reads

[Disseminated histoplasmosis in patients with AIDS. Buenos Aires, 2009-2014].

Medicina (B Aires) 2016;76(6):332-337

Centro de Micología, Departamento de Microbiología, Parasitología e Inmunología, Facultad de Medicina, Universidad de Buenos Aires, Argentina.

A retrospective study was carried out on 171 cases of disseminated histoplasmosis diagnosed in HIV/AIDS patients during the period 2009-2014. Although HIV diagnosis rates remained stable over the study period, a sensible increase in the number of histoplasmosis cases was observed in the last three years. Disseminated histoplasmosis was prevalent in males with an average age of 37. Read More

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August 2017
4 Reads

Acral manifestations of viral infections.

Clin Dermatol 2017 Jan - Feb;35(1):40-49. Epub 2016 Sep 10.

Emeritus Professor of Gazi University, Faculty of Medicine, Department of Dermatology, Beşevler, Ankara, Turkey.

Viruses are considered intracellular obligates with a nucleic acid RNA or DNA. They have the ability to encode proteins involved in viral replication and production of the protective coat within the host cells but require host cell ribosomes and mitochondria for translation. The members of the families Herpesviridae, Poxviridae, Papovaviridae, and Picornaviridae are the most commonly known agents for cutaneous viral diseases, but other virus families, such as Adenoviridae, Togaviridae, Parvoviridae, Paramyxoviridae, Flaviviridae, and Hepadnaviridae, can also infect the skin. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2016.09.006DOI Listing
June 2017
10 Reads

Severe Cutaneous Adverse Reactions: The Pharmacogenomics from Research to Clinical Implementation.

Int J Mol Sci 2016 Nov 15;17(11). Epub 2016 Nov 15.

Whole-Genome Research Core Laboratory of Human Diseases, Chang Gung Memorial Hospital, Keelung 204, Taiwan.

Severe cutaneous adverse reactions (SCARs), previously thought to be idiosyncratic or unpredictable, are a deadly form of adverse drug reactions with skin manifestations. Current pharmacogenomic studies of SCARs have made important strides, as the prevention of SCARs, to some extent, appears attainable with the identification of genetic variants for genes encoding drug-metabolizing enzymes and human leukocyte antigens (HLAs). Despite the improvement of incidence, a treatment guideline for this devastating condition is still unavailable, highlighting the inadequacy of contemporary accepted therapeutic interventions. Read More

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http://dx.doi.org/10.3390/ijms17111890DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133889PMC
November 2016
6 Reads

Hepatic porphyria: A narrative review.

Indian J Gastroenterol 2016 Nov 31;35(6):405-418. Epub 2016 Oct 31.

Department of Internal Medicine, UAB University of Alabama in Birmingham, Birmingham, AL, USA.

Porphyrias are a group of metabolic disorders, which result from a specific abnormality in one of the eight enzymes of the heme biosynthetic pathway. These have been subdivided based on the predominant site of enzyme defect into hepatic and erythropoietic types and based on clinical presentation into acute neurovisceral and cutaneous blistering porphyrias. This review focuses on hepatic porphyrias, which include acute intermittent porphyria (AIP), variegate porphyria (VP), hereditary coproporphyria (HCP), aminolevulinic acid dehydratase deficiency porphyria (ADP), and porphyria cutanea tarda (PCT). Read More

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http://dx.doi.org/10.1007/s12664-016-0698-0DOI Listing
November 2016
21 Reads

[Uncommon cutaneous presentation of visceral Leishmaniasis associated with HIV].

Ann Dermatol Venereol 2016 Dec 11;143(12):841-845. Epub 2016 Oct 11.

Service de maladies infectieuses et tropicales, CHU de Poitiers, 2, rue de la Milétrie, 86021 Poitiers, France.

Background: Visceral leishmaniasis is not normally expressed in skin. Herein, we describe the case of an HIV-positive patient who developed two unusual skin manifestations during an episode of visceral leishmaniasis.

Patients And Methods: A 48-year-old female patient consulted initially for infiltrated purpura of all four limbs. Read More

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http://dx.doi.org/10.1016/j.annder.2016.09.027DOI Listing
December 2016
7 Reads

Pulmonary Kaposi's sarcoma in a female patient: Case report.

Rev Assoc Med Bras (1992) 2016 Sep-Oct;62(5):395-8

Graduate degree - MD, Medical Clinic and Cardiology Resident, Hospital Barão de Lucena, Recife, PE, Brazil.

Kaposi's sarcoma (KS) is a multicentric lymphoproliferative malignancy. Most of the time this tumor is confined to the skin and subcutaneous tissue, but it can present with widespread visceral involvement, such as in the lung. Pulmonary KS is the most frequent form in young adult males, in a ratio of 15:1. Read More

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http://dx.doi.org/10.1590/1806-9282.62.05.395DOI Listing
April 2017
2 Reads

Kaposi's Sarcoma Presenting as Lymphadenopathy in an Immunocompetent Patient.

Eur J Case Rep Intern Med 2016 19;3(7):000493. Epub 2016 Sep 19.

Department of Internal Medicine, Rabta Hospital, Tunis, Tunisia.

Introduction: Kaposi's sarcoma (KS) is an angioproliferative disorder first described in 1872 by Moritz Kaposi. Four main clinical presentations of KS have been described: classic, endemic, iatrogenic and epidemic. KS involvement of the lymph nodes is extremely uncommon in the classical variant form, especially if it precedes the skin manifestations. Read More

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http://dx.doi.org/10.12890/2016_000493DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6346768PMC
September 2016

Kaposi Sarcoma of the eyelid as an initial manifestation of AIDS.

Dermatol Online J 2016 Jul 15;22(7). Epub 2016 Jul 15.

Department of Dermatovenereology of Centro Hospitalar de Lisboa Norte, Lisboa, Portugal.

Kaposi sarcoma (KS) is a multifocal systemic disease that originates in the vascular endothelium related to Human Herpes Virus 8 (HHV-8). In the early 1980s the first series of cases of disseminated Kaposi Sarcoma in HIV infected patients were reported. However, with the advent of highly active antiretroviral therapy (HAART) since 1997, these cases are less frequently observed by clinicians. Read More

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July 2016
27 Reads

Skin conditions in a South African tuberculosis hospital: Prevalence, description, and possible associations.

Int J Dermatol 2016 Nov;55(11):1234-1241

Division of Dermatology, Department of Medicine, University of Stellenbosch and Tygerberg Academic Hospital, Tygerberg, Cape Town, South Africa.

Background: The current pandemic of tuberculosis (TB) and human immunodeficiency virus (HIV) co-infection, the modern era of antiretroviral therapy, and the rising incidence of multidrug-resistant TB have led to a broader spectrum of skin conditions in patients hospitalized with TB. These factors also influence investigations into possible causal relationships with TB.

Objectives: The aim of this study was to describe mucocutaneous conditions found in patients hospitalized with TB and to report associated factors. Read More

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http://doi.wiley.com/10.1111/ijd.13355
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http://dx.doi.org/10.1111/ijd.13355DOI Listing
November 2016
6 Reads

MULTIFOCAL CHOROIDITIS IN DISSEMINATED SPOROTRICHOSIS IN PATIENTS WITH HIV/AIDS.

Retin Cases Brief Rep 2017 Winter;11(1):67-70

*Laboratório de Pesquisa Clínica em Oftalmologia Infecciosa, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; †Laboratório de Pesquisa Clínica em Dermatologia Infecciosa, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; ‡Centro Hospitalar do Instituto Nacional de Infectologia, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil; and §Laboratório de Micologia, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Purpose: In this article, the authors describe multifocal choroiditis related to disseminated sporotrichosis in patients with HIV/AIDS.

Methods: We conducted a retrospective observational study of three patients infected with HIV who presented with disseminated sporotrichosis characterized by cutaneous lesions, multifocal choroiditis, and other manifestations, including osteomyelitis and involvement of the bone marrow, larynx, pharynx, and nasal and oral mucosa.

Results: Five eyes of three patients with HIV/AIDS showed multifocal choroiditis related to disseminated sporotrichosis. Read More

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http://dx.doi.org/10.1097/ICB.0000000000000290DOI Listing
April 2017
7 Reads

Idiopathic Pyoderma Gangrenosum as a Novel Manifestation of the HIV Immune Reconstitution Inflammatory Syndrome: A Report of Three Cases.

J Assoc Physicians India 2015 Jul;63(7):72-6

The initiation of antiretroviral treatment for individuals with HIV may be accompanied by a paradoxical flare of underlying inflammatory diseases, the recurrence of dormant infections, or worsening of prior treated opportunistic infections, termed the immune reconstitution inflammatory syndrome (IRIS). Cutaneous manifestations of IRIS are common. Pyoderma gangrenosum is a neutrophilic dermatosis postulated to reflect disrupted innate immune regulation causing altered neutrophil chemotaxis. Read More

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July 2015
6 Reads

Atypical Cutaneous Manifestations in Syphilis.

Actas Dermosifiliogr 2016 May 23;107(4):275-83. Epub 2015 Dec 23.

Departamento de Microbiología, Centro Sanitario Sandoval, Madrid, España.

Although the diversity of the clinical manifestations of syphilis is well-known, atypical presentations can also occur. Such atypical presentations are associated with a high risk of transmission as a result of diagnostic confusion and treatment delays owing to the disease's ability to mimic other common skin diseases, deviate from classic clinical presentations, and adopt unique forms. Cases of atypical syphilis have been described most frequently in patients with concomitant human immunodeficiency virus (HIV) infection. Read More

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http://dx.doi.org/10.1016/j.ad.2015.11.002DOI Listing
May 2016
3 Reads

Effect of antiretroviral therapy on mucocutaneous manifestations among Human Immunodeficiency Virus-infected patients in a tertiary care centre in South India.

Indian J Sex Transm Dis AIDS 2015 Jul-Dec;36(2):166-73

Department of Dermatology, Jawaharlal Institute of Post Graduate Medical Education and Research, Puducherry, India.

Background: Human Immunodeficiency Virus (HIV) infection produces a wide range of infectious and noninfectious dermatoses which correlate with the degree of immunodeficiency. Since the introduction of highly active antiretroviral therapy (HAART), there has been a dramatic decrease in the incidence of HIV-associated dermatoses. However, HAART itself causes various cutaneous adverse drug reactions. Read More

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http://dx.doi.org/10.4103/0253-7184.167160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660558PMC
December 2015
8 Reads

Cutaneous tuberculosis overview and current treatment regimens.

Tuberculosis (Edinb) 2015 Dec 25;95(6):629-638. Epub 2014 Dec 25.

Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. Electronic address:

Tuberculosis is one of the oldest diseases known to humankind and it is currently a worldwide threat with 8-9 million new active disease being reported every year. Among patients with co-infection of the human immunodeficiency virus (HIV), tuberculosis is ultimately responsible for the most deaths. Cutaneous tuberculosis (CTB) is uncommon, comprising 1-1. Read More

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http://dx.doi.org/10.1016/j.tube.2014.12.006DOI Listing
December 2015
6 Reads

HPV Carcinomas in Immunocompromised Patients.

J Clin Med 2015 Jan 29;4(2):260-81. Epub 2015 Jan 29.

Medical School, the University of Texas Health Science Center at Houston, 1401 Binz, Suite 200, Houston, TX 77004, USA.

Human papillomavirus (HPV) infection is the most common sexually transmitted disease worldwide and can result in pre-malignancies or overt malignancies of the skin and mucosal surfaces. HPV-related illnesses are an important personal and public health problem causing physical, mental, sexual and financial detriments. Moreover, this set of malignancies severely affects the immunosuppressed population, particularly HIV-positive patients and organ-transplant recipients. Read More

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http://dx.doi.org/10.3390/jcm4020260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4470124PMC
January 2015
33 Reads

Cutaneous Cryptococcus: marker for disseminated infection.

BMJ Case Rep 2015 Jul 21;2015. Epub 2015 Jul 21.

Department of Dermatology and Venereology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.

Cryptococcosis is an infection caused by the encapsulated yeast, Cryptococcus neoformans, a dimorphic fungus recovered from pigeon excreta, soil, dust and human skin. After a primary infection in the lungs, the disease can disseminate via a haematogenous route to various organs, including the central nervous system and skin, in susceptible individuals. Cryptococcosis can present with a variety of skin and soft tissue manifestations including acneiform lesions, purpura, vesicles, nodules, abscesses, ulcers, granulomas, pustules, draining sinuses and cellulitis. Read More

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http://casereports.bmj.com/content/2015/bcr-2015-210898.full
Web Search
http://casereports.bmj.com/lookup/doi/10.1136/bcr-2015-21089
Publisher Site
http://dx.doi.org/10.1136/bcr-2015-210898DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4513468PMC
July 2015
12 Reads

[HIV/AIDS masks in a therapist's practice].

Ter Arkh 2015 ;87(4):41-46

V.I. Razumovsky Saratov State Medical University, Ministry of Health of Russia, Saratov, Russia.

Aim: To investigate clinical manifestations and diagnostic difficulties in patients with HIV/AIDS in the practice of therapeutic units of a multidisciplinary hospital.

Subjects And Methods: The investigation included 65 HIV/AIDS patients admitted to the therapy units of a Saratov Regional clinical hospital in 2007 to 2011. The clinical features of HIV/AIDS, immunological status, and viral load were studied. Read More

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http://dx.doi.org/10.17116/terarkh201587441-46DOI Listing
July 2015
10 Reads

[Imported histoplasmosis].

Dtsch Med Wochenschr 2015 Jun 12;140(12):913-6. Epub 2015 Jun 12.

Abteilung Infektiologie, Klinik für Innere Medizin II, Universitätsklinikum Freiburg.

Infections with Histoplasma capsulatum are rare in Germany, and mostly imported from endemic areas. Infections can present as localized or disseminated diseases in immunocompromised as well as immunocompetent hosts. A travel history may be a major clue for diagnosing histoplasmosis. Read More

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http://dx.doi.org/10.1055/s-0041-102040DOI Listing
June 2015
10 Reads