538 results match your criteria Cutaneous Manifestations of HIV Disease

Vasculitis in a case of rupioid syphilis in HIV.

Proc (Bayl Univ Med Cent) 2022 24;35(3):348-349. Epub 2022 Feb 24.

Trinity Vista Dermatology, Fort Worth, Texas.

Secondary syphilis can present with a diffuse, nonpruritic, contagious skin rash. The most common presentation of the rash consists of reddish-brown macules and papules seen on the palms and soles, often with papules and plaques on the torso and proximal extremities. However, the presentation may also include warty or raised mucous membrane lesions or patchy alopecia. Read More

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February 2022

Nasal cartilage destruction associated to cutaneous histoplasmosis in AIDS.

BMC Infect Dis 2022 Apr 14;22(1):377. Epub 2022 Apr 14.

Universidad Espíritu Santo, Samborondón, Ecuador.

Background: Systemic histoplasmosis is a disease of high morbidity and mortality in immunocompromised patients. Patients with AIDS get the infection through inhalation of spores, triggering a primary lung infection with a subsequent hematogenous spread to multiple organs, including the skin. Tissue necrosis have been documented in cutaneous histoplasmosis with multiple clinical manifestations that mimic other diseases. Read More

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Cutaneous tuberculosis. Part I: Pathogenesis, classification, and clinical features.

J Am Acad Dermatol 2022 Feb 8. Epub 2022 Feb 8.

Department of Dermatology, University College of Medical Sciences & GTB hospital, Delhi, India.

Tuberculosis is an ancient disease that continues to affect an estimated 10 million people per year and is responsible for 1.4 million deaths per year. Additionally, the HIV epidemic and multi-drug resistance present challenges to disease control. Read More

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February 2022

The Great Imitator: Atypical Cutaneous Manifestations of Primary Syphilitic Chancre.

Chin Med Sci J 2021 Dec;36(4):279-283

Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.

Objective To analyze the reasons of misdiagnosis of primary syphilitic chancre and strengthen the understanding of atypical features of this disease. Methods A case series of twenty-seven challenging primary syphilis patients who were not immediately recognized as chancre was included in our study. The clinical data including the patients' age, sex, skin lesions, HIV status, syphilis serologic test results, treatment, and follow-up results were collected. Read More

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December 2021

Acute HIV Infection Presenting With Diffuse Plaque Psoriasis Treated With Highly Active Antiretroviral Therapy.

Cureus 2021 Nov 17;13(11):e19680. Epub 2021 Nov 17.

Dermatology, Jamaica Hospital Medical Center, Queens, USA.

Cutaneous diseases such as psoriasis are often the first disease manifestations in HIV+ patients, with greater severity corresponding to a weaker immune system. Despite its prevalence, literature and placebo-controlled studies on the recognition of HIV as a cause of psoriasis are lacking, causing challenges to arise in its treatment. In this article, we illustrate a case of an HIV+ patient whose psoriasis drastically improved after the initiation of highly active antiretroviral therapy (HAART) consisting of bictegravir, emtricitabine, and tenofovir alafenamide. Read More

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November 2021

Onycho-mucocutaneous syndrome secondary to human immunodeficiency virus disease.

Indian J Sex Transm Dis AIDS 2021 Jul-Dec;42(2):150-153. Epub 2021 Jul 27.

Department of Dermatology, Venereology and Leprosy, Yenepoya Medical College, Yenepoya (Deemed to be) University, Mangalore, Karnataka, India.

Cutaneous, mucosal, and nail examination is the key to unveiling a plethora of systemic diseases. Mucocutaneous lesions directly related to human immunodeficiency virus (HIV) infection usually present as initial manifestations of immune deficiency, of which few lesions act as predictors of an immunocompromised state. Here, we report two cases who presented with onycho-mucocutaneous symptoms which raised the suspicion of and invariably led to the diagnosis of an underlying immunosuppression secondary to HIV infection. Read More

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Mucocutaneous mycoses in people living with human immunodeficiency virus in Indonesia.

Mycoses 2022 Mar 30;65(3):323-330. Epub 2021 Dec 30.

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia - dr. Cipto Mangunkusumo National Central General Hospital, Central Jakarta, Jakarta, Indonesia.

Background: To date, integrated care for people living with human immunodeficiency virus (PLHIV) has improved. However, although the management of mucocutaneous mycosis cases has improved, disease progression might be different in immunocompromised patients, which leads to variable clinical manifestations.

Objectives: To describe the characteristics of mucocutaneous mycosis cases in the PLHIV population and its associated factors in Indonesia. Read More

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First Subungual Cryptococcosis Described in an HIV Patient with Disseminated Cryptococcosis.

Skin Appendage Disord 2021 Nov 23;7(6):480-482. Epub 2021 Jun 23.

Department of Dermatology and Venerology, Ibn Rochd University Hospital, Casablanca, Morocco.

Background: Cutaneous cryptococcosis occurs in 10-15% of patients with disseminated cryptococcosis. It typically presents as papulonodular molluscum-like lesions, but it can also produce a wide variety of lesions. Cryptococcal infection of the nail unit has never been reported. Read More

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November 2021

Clinical Spectrum of Rheumatic Manifestations in HIV Infected Males at a Tertiary Care Hospital.

J Assoc Physicians India 2021 Oct;69(10):11-12

Physician and Endocrinologist, Command Hospital Air Force Bangalore, Karnataka.

Background: In the current era of effective Anti retroviral therapy (ART), and Human Immunodeficiency Virus (HIV) infection becoming a chronic illness, there has been a gradual rise in the prevalence of rheumatic manifestations associated with this disease. These are characterized by a modified clinical course and widened spectrum of a few emerging rheumatic manifestations seen with HIV infection.

Aims And Objectives: To assess the type, frequency, prevalence and clinical spectrum of rheumatic manifestations among &male patients followed at an HIV clinic of a tertiary care defence hospital. Read More

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October 2021

New-onset cutaneous kaposi's sarcoma following SARS-CoV-2 infection.

J Cosmet Dermatol 2021 Dec 3;20(12):3747-3750. Epub 2021 Nov 3.

Freelance Dermatologists, Rome, Italy.

Background: COVID-19 is associated with several cutaneous manifestations, including chilbain-like lesions, urticaria, erythema multiforme, and maculopapular lesions. Dermatoses may be directly linked to the viral infection or also represent a consequence of systemic therapies administrated for COVID-19. A potential role of SARS-CoV-2 in triggering the reactivation of other viruses, such as HHV-6, HHV-7 and Epstein-Barr virus has been hypothesized. Read More

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December 2021

Tattoo-Associated Viral Infections: A Review.

Philip R Cohen

Clin Cosmet Investig Dermatol 2021 23;14:1529-1540. Epub 2021 Oct 23.

Department of Dermatology, University of California, Davis Medical Center, Sacramento, CA, USA.

Tattoos, a decorative form of body art, are produced by inoculating pigment into the dermis. Tattoo-associated viral infections can be cutaneous and localized to the tattoo ink; however, viral pathogens acquired during inoculation can cause systemic disease. A comprehensive review of the literature only reveals a limited number of published reports regarding patients with tattoo-associated cutaneous viral lesions. Read More

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October 2021

Cutaneous manifestations and dermoscopic findings are important clues to the diagnosis of Talaromyces marneffei in HIV patients with immune reconstitution inflammatory syndrome: A case report and literature review.

J Dermatol 2022 Jan 15;49(1):168-172. Epub 2021 Oct 15.

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Talaromyces (formerly Penicillium) marneffei is a dimorphic fungus that causes talaromycosis (formerly penicilliosis). The condition is predominantly found in patients with HIV. Important diagnostic clues are a history of living or travelling in endemic areas, and central umbilicated skin lesions. Read More

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January 2022

A Case of Disseminated Cutaneous Herpes Simplex Virus-1 as the First Manifestation of Human Immunodeficiency Virus Infection.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211045245

Creighton University School of Medicine, Phoenix, AZ, USA.

Reported clinical manifestations of active herpes simplex virus type 1 (HSV-1) infection include typically painful vesicular cutaneous rash in a dermatomal distribution, temporal lobe encephalitis, and rarely, fulminant septic shock with multiorgan failure. In immunocompromised patients, the cutaneous rash can become disseminated. We report a case of a 33-year-old male patient with undiagnosed human immunodeficiency virus (HIV) infection who presented to our emergency department (ED) with a disseminated cutaneous rash. Read More

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October 2021

Dermatological Opportunistic Infections in HIV Seropositive Patients: An Observational Study.

Cureus 2021 Aug 3;13(8):e16852. Epub 2021 Aug 3.

Department of Internal Medicine, Pandit Deendayal Upadhyay Medical College, Rajkot, IND.

Background and objective In developing countries, the dermatological manifestation of the human immunodeficiency virus (HIV) has a high prevalence. Apart from the systemic infection that ensues HIV, skin manifestations form a major part of the disease burden. They can present with atypical forms, and necessary tools for diagnosis may not be available in rural and remote parts of the country. Read More

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Diffuse Lymphadenopathy Syndrome as a Flare-Up Manifestation in Lupus and Mixed Connective Tissue Disease Following Mild COVID-19.

Am J Case Rep 2021 Sep 10;22:e932751. Epub 2021 Sep 10.

Rheumatology Section, Clinical Hospital of the University of Chile, Santiago, Chile.

BACKGROUND Manifestations of Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, are highly variable among healthy populations. In connective tissue disease patients, the spectrum of clinical manifestations is even broader. In mild COVID-19 patients, diffuse lymphadenopathy (DL) has not been described as a late manifestation, and only severe COVID-19 has been associated with lupus flare-ups. Read More

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September 2021

Toxic epidermal necrolysis with systemic lupus erythematosus: case report and review of the literature.

Ann Palliat Med 2021 Aug 16. Epub 2021 Aug 16.

Emergency Department, Peking University Third Hospital, Beijing, China.

Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are potentially fatal mucocutaneous diseases characterized by extensive necrosis and exfoliation of the epidermis. TEN and SJS are most often caused by various kinds of drugs. Other risk factors for SJS/TEN include pneumonia infection, HIV infection, genetic factors, underlying immune diseases, and tumors. Read More

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An abdominal skin lesion: to lump or split? a case presentation.

Dermatol Online J 2021 Jun 15;27(6). Epub 2021 Jun 15.

School of Medicine, University of California San Francisco, San Francisco, CA.

Syphilis has many atypical morphologies which can present a diagnostic challenge, especially in patients with HIV/AIDS who may have multiple concurrent conditions. We describe a 41-year-old man with recently diagnosed HIV who was admitted for acute right vision loss and a diffuse rash with involvement of the palms and soles. He received diagnoses of secondary syphilis and Kaposi sarcoma in the setting of AIDS. Read More

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Histoplasma capsulatum var. duboisii: A KwaZulu-Natal, South Africa public sector perspective.

J Cutan Pathol 2022 Feb 25;49(2):139-146. Epub 2021 Aug 25.

Department of Anatomical Pathology, National Health Laboratory Service & School of Laboratory Medicine and Medical Sciences, University of KwaZulu-Natal, Durban, South Africa.

Background: Histoplasma capsulatum var. duboisii (H. duboisii) causes potentially fatal disease in the immunocompromised patient, and the literature on these cases is limited. Read More

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February 2022

Histopathology and immunophenotyping of late onset cutaneous manifestations of COVID-19 in elderly patients: Three case reports.

World J Clin Cases 2021 Jul;9(20):5744-5751

Department of Medical and Surgical Sciences, Infectious and Tropical Disease Unit, Magna Graecia University, Catanzaro 88100, Italy.

Background: Several cutaneous manifestations such as urticarial rash, erythematous patches and chilblain-like lesions have been described in young adults with coronavirus disease 2019 (COVID-19) and are present in up to 20% patients, but few reports exist describing histopathological and immunophenotypic characteristics of dermatological lesions in older patients. Our aim was to characterize skin lesions in elderly patients during late stages of COVID-19 from clinical, histological and immunophenotypic perspectives.

Case Summary: Three patients, admitted for COVID-19, and who developed cutaneous manifestations underwent skin biopsies. Read More

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Principles of evidence-based medicine: from Robert Kochs postulates to a current EBM concept.

Vladimír Bencko

Cas Lek Cesk 2021 ;160(2-3):93-96

The aim of the article is to describe the development of the principles of medicine based on the evidence (EBM) based on postulates of Robert Koch, Nobel prize winner, protagonist of the "Golden Age" medical bacteriology, founder of a concept of modern microbiology and infectology. Kochs work led to the discovery of a causal relationship between exposure to a specific pathogen and disease on the example of identifying the cause of anthrax - Bacillus anthracis, a disease whose symptoms vary depending on the mode of transmission (gastrointestinal ingestion, cutaneous form on contact and pulmonary manifestations when inhaled). Tuberculosis caused by Kochs bacillus, Mycobacterium tuberculosis, yet still affecting 1. Read More

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Unusual clinical manifestation and challenging serological interpretation of syphilis: insights from a case report.

BMC Infect Dis 2021 Jun 2;21(1):521. Epub 2021 Jun 2.

STI/HIV Unit, San Gallicano Dermatological Institute IRCCS, Rome, Italy.

Background: The clinical manifestations of recent syphilis can be variable, with typical and atypical patterns. Several conditions may cause atypical clinical aspects, including human immunodeficiency virus (HIV) co-infection. Besides the clinical features, co-infections may completely alter syphilis serological tests, causing interpretative difficulties and diagnostic delays. Read More

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Sociodemographic determinants and clinical risk factors associated with COVID-19 severity: a cross-sectional analysis of over 200,000 patients in Tehran, Iran.

BMC Infect Dis 2021 May 25;21(1):474. Epub 2021 May 25.

Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Background: Defining socio-demographic factors, clinical presentations and underlying diseases associated with COVID-19 severity could be helpful in its management. This study aimed to further clarify the determinants and clinical risk factors of the disease severity in patients infected with COVID-19.

Methods: A multi-centre descriptive study on all patients who have been diagnosed with COVID-19 in the province of Tehran from March 2020 up to Dec 2020 was conducted. Read More

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A disseminated Mycobacterium marinum infection in a renal transplant HIV-infected patient successfully treated with a bedaquiline-containing antimycobacterial treatment: A case report.

Int J Infect Dis 2021 Jun 16;107:176-178. Epub 2021 Apr 16.

Department of Infectious Diseases, Tourcoing Hospital, France.

Background: Disseminated Mycobacterium marinum infections occur rarely, in immunocompromised patients. Treatment with a prolonged multi-drug regimen exposes patients to drug-drug interactions and side effects.

Case Report: We report a case of disseminated M. Read More

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N-acetylcysteine and coronavirus disease 2019: May it work as a beneficial preventive and adjuvant therapy? A comprehensive review study.

J Res Med Sci 2020 26;25:109. Epub 2020 Nov 26.

Department of Dermatology, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran.

Background: Coronaviruses are major pathogens of respiratory system causing different disorders, including the common cold, Middle East respiratory syndrome, and severe acute respiratory syndrome. Today's global pandemic coronavirus disease 2019 (COVID-19) has high mortality rate, with an approximate of 20% in some studies, and is 30-60 times more fatal than the common annual influenza, However, there is still no gold standard treatment for it. N-acetylcysteine (NAC) is a well-known multi-potential drug with hypothetically probable acceptable effect on COVID-related consequences, which we completely focused in this comprehensive review. Read More

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November 2020

Vulvovaginal candidiasis in Iran: A systematic review and meta-analysis on the epidemiology, clinical manifestations, demographic characteristics, risk factors, etiologic agents and laboratory diagnosis.

Microb Pathog 2021 May 16;154:104802. Epub 2021 Mar 16.

Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Food Microbiology Research Center, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Vulvovaginal candidiasis is a global issue of concern due to its association with economic costs, sexually transmitted infections, and ascending genital tract diseases. This infection affects 75% of women on at least one occasion over a lifetime. The present systematic review and meta-analysis is the first to determine the prevalence of vulvovaginal candidiasis in Iranian women. Read More

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Cutaneous manifestations of patients with Human Immunodeficiency Virus (HIV) Infection: A retrospective review of a tertiary referral centre with clinicopathological correlation.

Australas J Dermatol 2021 Aug 17;62(3):286-291. Epub 2021 Mar 17.

Infectious Diseases Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

Introduction: The majority of patients with Human Immunodeficiency Virus (HIV) will have cutaneous manifestation during their disease course. We report the spectrum of cutaneous manifestations and clinicopathological concordance in the diagnosis of skin diseases in patients with HIV.

Methods: A retrospective review of all cutaneous manifestations of HIV-infected patients with skin biopsy-proven histopathological confirmation, treated in the University of Malaya Medical Centre, from 2016 till 2018, was performed. Read More

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Cutaneous and Mucocutaneous Leishmaniasis.

Actas Dermosifiliogr (Engl Ed) 2021 Feb 27. Epub 2021 Feb 27.

Servicio de Dermatología, Hospital Universitario Miguel Servet, Zaragoza, España.

Leishmaniasis is a chronic disease caused by flagellate protozoa of the genus Leishmania. It is a global disease, but most cases are seen in South America, the Mediterranean, and some areas of Asia and Africa. The 3 main types of leishmaniasis are cutaneous (the most common), mucocutaneous, and visceral (the most severe). Read More

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February 2021

Cutaneous smooth muscle tumors associated with Epstein-Barr virus in an adult patient with HIV.

An Bras Dermatol 2021 Mar-Apr;96(2):184-187. Epub 2021 Feb 4.

Dermatology Service, CES University, Medellín, Antioquia, Colombia.

Epstein Barr virus-associated smooth muscle tumors are an uncommon neoplasm that occurs in immunosuppressed patients of any age. Usually, it presents as multifocal tumors mainly in the spinal cord, epidural region, gastrointestinal tract and liver, upper respiratory tract and skin, the latest with few cases reported in the literature and related with human immunodeficiency virus infection and acquired immune deficiency syndrome. The authors present the first case of a Colombian adult patient with human immunodeficiency virus infection and multifocal Epstein Barr virus-associated smooth muscle tumors in the skin and epidural region, confirmed by histopathology, immunohistochemistry and in situ hybridization studies. Read More

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Cutaneous Histoplasmosis in HIV Seronegative Patients: A Clinicopathological Analysis.

Dermatology 2021 24;237(6):934-939. Epub 2021 Feb 24.

Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences, Dr. RML Hospital, New Delhi, India.

Background: Diagnosis of extrapulmonary histoplasmosis in HIV seronegative and immunocompetent patients is often challenging, so a high index of suspicion is required. Cutaneous manifestation of infection shows a wide spectrum of lesions including erythematous plaques; maculopapules; crusted, verrucous, or desquamative papules and nodules; abscesses; and mucocutaneous ulcers among others. Due to the variations in its clinical presentation, histopathology plays a very important role in the detection of spores and the confirmation of diagnosis. Read More

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February 2022

Varicella-Zoster Virus Meningitis and Encephalitis: An Understated Cause of Central Nervous System Infections.

Cureus 2020 Nov 20;12(11):e11583. Epub 2020 Nov 20.

Internal Medicine, University of Sucre, Sincelejo, COL.

Background Varicella-zoster virus (VZV) and herpes zoster cause infections of the central nervous system (CNS) manifesting as meningitis or encephalitis. As compared to enterovirus (EV) and herpes simplex virus 1 (HSV-1) and 2 (HSV-2), it is not often tested in CNS infections due to VZV and herpes zoster. There is a certain tendency to think that the findings in the cerebrospinal fluid in infections of the CNS by viruses are comparable among themselves. Read More

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November 2020