495 results match your criteria Cutaneous Manifestations of HIV Disease


Cutaneous manifestations associated with HIV infections: A great imitator.

Clin Dermatol 2020 Mar - Apr;38(2):160-175. Epub 2019 Oct 24.

Department of Dermatology, Şişli Hamidiye Etfal Research and Training Hospital, Health Science University, Istanbul, Turkey.

HIV is associated with an increased incidence of mucocutaneous disorders, with the overwhelming majority of HIV-infected individuals being afflicted with skin diseases during the course of the infection. Skin diseases in HIV patients are rarely fatal, but they have a significant effect on the quality of life. The immunologic stage of the infection and the use of highly active antiretroviral therapy (HAART) are the main elements that determine the spectrum of the mucocutaneous involvement. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.10.001DOI Listing
October 2019

: an underlying immunosuppression? Clinical manifestations, pathogenesis, diagnostic examinations and treatment.

Postepy Dermatol Alergol 2020 Apr 5;37(2):154-158. Epub 2020 May 5.

Department of Dermatology, Venereology and Allergology, Medical University of Gdansk, Gdansk, Poland.

Due to constantly growing population of immunocompromised patients the fungi became a widespread threat to modern medicine. HIV carriers, solid organ transplant recipients constitute most of those patients. Cryptococcosis is a frequent cause of life-threatening infections, affecting mostly immunosuppressed patients. Read More

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http://dx.doi.org/10.5114/ada.2020.94833DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262803PMC

Prevalence of pruritic papular eruption among HIV patients: A cross-sectional study.

Indian J Sex Transm Dis AIDS 2019 Jul-Dec;40(2):146-151

Science Health Allied Research and Education India Foundation, Hyderabad, Telangana, India.

Introduction: Pruritic papular eruption (PPE) remains as one of the most common cutaneous manifestations in HIV-infected patients. Proper knowledge about understanding the risk factors associated with this disease may help to decrease the prevalence of PPE.

Objective: The present study was conducted to determine the prevalence of PPE in HIV-infected patients and to correlate between the severity of PPE and individual CD4 count. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_69_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6896392PMC
January 2020

Cutaneous Cryptococcosis

Med Mycol J 2019 ;60(4):101-107

Department of Dermatology and Plastic Surgery, Kumamoto University.

Cutaneous cryptococcosis is classified either as primary or secondary based on the route of infection. The disease can also be classified either as localized cutaneous cryptococcosis or cutaneous manifestations of disseminated cryptococcosis. However, from a physician's point of view, whether lesions are localized to the skin or are disseminated/systemic is more important than the route of infection. Read More

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http://dx.doi.org/10.3314/mmj.19.008DOI Listing

Cutaneous Manifestations of Human Immunodeficiency Virus/AIDS Patients in Albania.

Int J Appl Basic Med Res 2019 Oct-Dec;9(4):197-200. Epub 2019 Oct 11.

Department of Epidemiology, Institute of Public Health, Tirana, Albania.

Context: Dermatologic diseases are common in the human immunodeficiency virus (HIV)-infected population. Cutaneous manifestations of HIV disease may result from HIV infection itself or from opportunistic disorders secondary to the declined immunocompetence due to the disease.

Aims: The aim of this study is to determine the pattern of c0utaneous manifestations in HIV in an adult HIV Clinic in Tirana. Read More

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http://dx.doi.org/10.4103/ijabmr.IJABMR_287_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6822325PMC
October 2019

Lower Gastrointestinal Kaposi Sarcoma in HIV/AIDS: A Diagnostic Challenge.

Gastrointest Tumors 2019 Aug 18;6(1-2):51-55. Epub 2019 Jul 18.

Department of General Internal Medicine, Morehouse School of Medicine, Atlanta, Georgia, USA.

Gastrointestinal Kaposi sarcoma (GI-KS) is the most common extra-cutaneous site of KS in HIV/AIDS, and the majority (75%) of affected patients are asymptomatic. GI-KS rarely occurs in the absence of cutaneous lesions. Opportunistic GI infections in HIV/AIDS and GI-KS can present with similar symptoms especially diarrhea, creating a diagnostic challenge. Read More

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http://dx.doi.org/10.1159/000500140DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6738214PMC
August 2019
3 Reads

Discrete cutaneous lesions in a critically ill patient treated only for AIDS and miliary tuberculosis: a case report of disseminated histoplasmosis.

Dermatol Online J 2019 Aug 15;25(8). Epub 2019 Aug 15.

Internal medicine resident of Nilton Lins Hospital (HNL), Manaus city, state of Amazon.

Histoplasmosis is a systemic mycosis caused by the dimorphic fungus Histoplasma capsulatum, with disseminated histoplasmosis (HD) being one of its clinical forms. As a consequence of the HIV-AIDS pandemic, HD has become prevalent not only in regions that are recognized as endemic but also in areas not considered endemic, such as Europe and Asia. Its clinical manifestations are varied and mimic several infectious diseases, mainly tuberculosis. Read More

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August 2019
5 Reads

Rowell Syndrome in Nigeria: Systemic Lupus Erythematosus Presenting as Recurrent Erythema Multiforme in a Young Woman.

Acta Dermatovenerol Croat 2019 Sep;27(3):200-201

Richard Akintayo, MD, Department of Medicine, University of Ilorin Teaching Hospital, Ilorin, Nigeria;

Dear Editor, Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease characterized by diverse patterns of auto-antibody production with multi-organ affectation. Cutaneous involvement, either alone or in association with other systemic illnesses, is one of its most common manifestations (1). Dermatologic disorders like malar and discoid rashes are quite suggestive of SLE. Read More

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September 2019
2 Reads

Rare presentation of bronchopulmonary Kaposi sarcoma.

BMJ Case Rep 2019 Aug 26;12(8). Epub 2019 Aug 26.

Department of Pulmonary Medicine, Aventura Hospital and Medical Center, Aventura, Florida, USA.

Kaposi sarcoma (KS) is an angioproliferative disorder that is commonly associated with human herpes virus 8 as well as the HIV. In fact, KS is one of the most common AIDS-defining illnesses. KS typically presents with diffuse, violaceous cutaneous nodules, and may have concomitant visceral involvement. Read More

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http://dx.doi.org/10.1136/bcr-2019-229436DOI Listing
August 2019
5 Reads

An unusual presentation of disseminated histoplasmosis in a non-HIV patient from Vietnam.

Rev Iberoam Micol 2019 Jul - Sep;36(3):147-150. Epub 2019 Aug 2.

Medical Technology School, Faculty of Science, Universidad Mayor, Huechuraba, Santiago, Chile. Electronic address:

Background: Histoplasmosis is a systemic infection caused by the dimorphic fungus Histoplasma capsulatum, naturally found in nitrogen-rich soil, whose main transmission route is the inhalation of conidia. Up to 95% of histoplasmosis cases are asymptomatic or transient, and the remaining 5% of cases have pathological manifestations in the lungs, bone marrow, liver, spleen, intestine, mucous membranes, and rarely on the skin. This mycosis has been reported from many endemic areas, mainly in immunosuppressed patients, such as HIV-positive patients, and its disseminated form is rarely reported. Read More

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http://dx.doi.org/10.1016/j.riam.2019.04.002DOI Listing
May 2020
2 Reads

Disseminated cutaneous-only histoplasmosis in a patient with AIDS.

Australas J Dermatol 2019 Nov 28;60(4):e330-e332. Epub 2019 Jun 28.

The Alfred Hospital, Prahran, Victoria, Australia.

Histoplasmosis is an opportunistic fungal infection that occurs predominantly in immunocompromised patients. Cutaneous lesions in histoplasmosis are rare and typically occur in the absence of extra-cutaneous manifestations. We present a rare case of disseminated cutaneous-only histoplasmosis in a patient with recently diagnosed AIDS. Read More

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http://dx.doi.org/10.1111/ajd.13108DOI Listing
November 2019
6 Reads
0.982 Impact Factor

Kaposi-like manifestations in a newly diagnosed AIDS transgendered patient with silicone embolism syndrome and disseminated tuberculosis.

Infez Med 2019 Jun;27(2):190-193

Fondazione Policlinico Universitario A. Gemelli IRCCS, Institute of Clinical Infectious Diseases, Rome, Italy; Università Cattolica del Sacro Cuore, Institute of Clinical Infectious Diseases, Rome, Italy.

The use of liquid silicone for cosmetic procedures can yield serious sequelae including embolization and pneumonia. We describe a recent case of silicone embolism syndrome occurring together with systemic tuberculosis in a transgendered patient newly diagnosed with AIDS. She presented with fever, hematochezia, lymphadenopathies, purple nodular lesions and lower limb edema. Read More

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June 2019
19 Reads

Cutaneous tuberculosis: A great imitator.

Clin Dermatol 2019 May - Jun;37(3):192-199. Epub 2019 Jan 11.

Department of Dermatology, Southwest Hospital, The Third Military Medical University, Chongqing, P.R. China.

Tuberculosis (TB) is still prevalent in many developing countries and can pose a new potential threat to global health due to international migration. As an uncommon form of extrapulmonary TB, cutaneous TB is complicated in its clinical manifestation, pathogenesis, and classification. Cutaneous TB can be divided into two major categories, true cutaneous TB and tuberculid, depending on the source of infection, the route of transmission, the amount of bacteria, and the immune state of the host. Read More

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http://dx.doi.org/10.1016/j.clindermatol.2019.01.008DOI Listing
December 2019
10 Reads

Metastatic squamous cell carcinoma of penis in an HIV-infected man presenting with cutaneous manifestations.

Int J STD AIDS 2019 05 4;30(6):613-616. Epub 2019 Feb 4.

Department of Dermatology, Topiwala National Medical College & B.Y.L. Nair Hospital, Mumbai, India.

The incidence of penile squamous cell carcinoma (SCC) varies widely in different parts of the world. It is rare in Western countries but common in developing countries like India. The glans and foreskin are the most commonly affected sites. Read More

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http://dx.doi.org/10.1177/0956462418813069DOI Listing
May 2019
6 Reads

Bone marrow involvement in sarcoidosis: an elusive extrapulmonary manifestation.

J Community Hosp Intern Med Perspect 2019 Apr 12;9(2):150-154. Epub 2019 Apr 12.

Department of Internal Medicine, SSM St. Mary's Hospital - St. Louis, St. Louis, MO, USA.

Sarcoidosis is a granulomatous disease with various extrapulmonary manifestations. We describe a 51-year-old African American woman with a history of cutaneous sarcoidosis admitted with bicytopenia. Suspicion for systemic sarcoidosis was established after contrast-enhanced computerized tomography of the chest, abdomen and pelvis showed a pulmonary nodule, diffuse lymphadenopathy and hepatosplenomegaly. Read More

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http://dx.doi.org/10.1080/20009666.2019.1575688DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6487444PMC
April 2019
20 Reads

Epidemiology and clinical characteristics of herpes zoster in a tertiary care hospital in Brazil.

Braz J Infect Dis 2019 Mar - Apr;23(2):143-145. Epub 2019 Mar 29.

Universidade Federal do Rio Grande do Sul, Hospital de Clínicas de Porto Alegre, Seção de Doenças Infecciosas, Porto Alegre, RS, Brazil. Electronic address:

Background: There is little information on herpes zoster from hospital registries in South America. The aim of this study was to describe the epidemiological and clinical aspects of herpes zoster (HZ) in hospitalized patients.'

Methods: We searched for hospital-based records during the period from March 2000 to January 2017 in a 700-bed tertiary-care hospital located in southern Brazil. Read More

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http://dx.doi.org/10.1016/j.bjid.2019.03.001DOI Listing
July 2019
13 Reads

Mucocutaneous manifestations of human immunodeficiency virus (HIV) infection in children in relation to the degree of immunosuppression.

Int J Dermatol 2019 Oct 29;58(10):1165-1171. Epub 2019 Mar 29.

Department of Dermatology, St. John's Medical College Hospital, Bangalore, India.

Background: Human immunodeficiency virus (HIV) infection in children is becoming a common occurrence. Worldwide, limited studies have been done on the mucocutaneous manifestations in HIV-positive children. The aim of our study was to analyze the spectrum of mucocutaneous manifestations of pediatric HIV infection and correlate to degree of immunosuppression. Read More

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http://dx.doi.org/10.1111/ijd.14440DOI Listing
October 2019
8 Reads

Psoriasis in HIV infection: an update.

Int J STD AIDS 2019 05 27;30(6):596-604. Epub 2019 Feb 27.

1 Dermatology and Venereology Department, Hospital de Santa Maria, Centro Hospitalar Lisboa Norte, Lisboa, Portugal.

Psoriasis is a prevalent systemic immune-mediated disease with cutaneous manifestations. In HIV-infected patients, psoriasis may have a higher incidence, present atypical and more exuberant clinical features, and is frequently recalcitrant to treatment. Despite this aggravated severity, treatment options for psoriasis in HIV-infected individuals remain limited due to the risk of fatal immunosuppression associated with both classical immunosuppressants and new biological drugs. Read More

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http://journals.sagepub.com/doi/10.1177/0956462419827673
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http://dx.doi.org/10.1177/0956462419827673DOI Listing
May 2019
6 Reads

[Histoplasmosis in AIDS patients without tegumentary manifestations].

Rev Chilena Infectol 2018;35(5):560-565

Unidad de Micología, Hospital de Enfermedades Infecciosas, Buenos Aires, Argentina.

Background: Histoplasmosis is a mycosis with a high prevalence in HIV/AIDS patients. Clinical presentation includes a wide spectrum of manifestations and diagnosis usually takes up to several weeks in patients who do not present cutaneous lesions.

Aim: To determine the clinical and microbiological characteristics as well as some biochemical parameters in patients with AIDS-associated histoplasmosis without tegumentary lesions, in order to develop a guideline which enables an early empiric treatment in cases of difficult diagnosis. Read More

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http://dx.doi.org/10.4067/s0716-10182018000500560DOI Listing
August 2019
13 Reads

Cutaneous cytomegalovirus manifestations, diagnosis, and treatment: a review.

Dermatol Online J 2019 Jan 15;25(1). Epub 2019 Jan 15.

McGovern Medical School of University of Texas Houston Health Science Center, Houston, Texas.

The possible presentations of cytomegalovirus (CMV) are vast not only in its systemic manifestations, but also in the various cutaneous lesions that may result. Cutaneous cytomegalovirus is rarely reported in the literature because the clinical and pathologic features can be difficult to identify. Its identification, however, is vital as cutaneous human CMV infection can signal systemic disease and an unfavorable prognosis. Read More

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January 2019
32 Reads

Unusual Clinical Manifestations of in an HIV-coinfected Patient and the Relevance of ITS1-PCR-RFLP: A Case Report.

Iran J Parasitol 2018 Oct-Dec;13(4):655-660

Laboratory of Parasitology, Institute of Tropical Medicine, University of São Paulo, São Paulo, Brazil.

Patients coinfected with /HIV can develop atypical forms of visceral leishmaniasis (VL), making it indispensable to identify the etiological agent. We are presenting a post-mortem specie definition by ITS1-PCR-RFLP in a larynx tissue of a patient presented coinfection /HIV. This patient was from a leishmaniasis endemic region in São Paulo (SP), Brazil, and was diagnosed clinically with mucocutaneous leishmaniasis. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6348215PMC
January 2019
8 Reads

Metagenomic Discovery of 83 New Human Papillomavirus Types in Patients with Immunodeficiency.

mSphere 2018 12 12;3(6). Epub 2018 Dec 12.

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland, USA.

Several immunodeficiencies are associated with high susceptibility to persistent and progressive human papillomavirus (HPV) infection leading to a wide range of cutaneous and mucosal lesions. However, the HPV types most commonly associated with such clinical manifestations in these patients have not been systematically defined. Here, we used virion enrichment, rolling circle amplification, and deep sequencing to identify circular DNA viruses present in skin swabs and/or wart biopsy samples from 48 patients with rare genetic immunodeficiencies, including patients with warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome, or epidermodysplasia verruciformis (EV). Read More

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http://msphere.asm.org/lookup/doi/10.1128/mSphereDirect.0064
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http://dx.doi.org/10.1128/mSphereDirect.00645-18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291628PMC
December 2018
59 Reads

Porphyria cutanea tarda and hepatoerythropoietic porphyria: Identification of 19 novel uroporphyrinogen III decarboxylase mutations.

Mol Genet Metab 2019 11 28;128(3):363-366. Epub 2018 Nov 28.

Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. Electronic address:

Porphyria Cutanea Tarda (PCT) is a cutaneous porphyria that results from the hepatic inhibition of the heme biosynthetic enzyme uroporphyrinogen decarboxylase (UROD), and can occur either in the absence or presence of an inherited heterozygous UROD mutation (PCT subtypes 1 and 2, respectively). A heterozygous UROD mutation causes half-normal levels of UROD activity systemically, which is a susceptibility factor but is not sufficient alone to cause type 2 PCT. In both Types 1 and 2 PCT, the cutaneous manifestations are precipitated by additional factors that lead to generation of an inhibitor that more profoundly reduces hepatic UROD activity. Read More

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http://dx.doi.org/10.1016/j.ymgme.2018.11.013DOI Listing
November 2019
20 Reads

Uncharted territory of the epidemiological burden of cutaneous leishmaniasis in sub-Saharan Africa-A systematic review.

PLoS Negl Trop Dis 2018 10 25;12(10):e0006914. Epub 2018 Oct 25.

Department of Public Health, Institute of Tropical Medicine, Antwerp, Belgium.

Introduction: Cutaneous leishmaniasis (CL) is the most frequent form of leishmaniasis, with 0.7 to 1.2 million cases per year globally. Read More

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http://dx.plos.org/10.1371/journal.pntd.0006914
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http://dx.doi.org/10.1371/journal.pntd.0006914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219817PMC
October 2018
14 Reads

Basidiobolomycosis in Togo: clinico-pathological study of a series of 12 presumed cases.

BMC Res Notes 2018 Sep 14;11(1):667. Epub 2018 Sep 14.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.

Objective: The purpose of our study was to describe the histological diagnosed of the Basidiobolomycosis cases from 1990 to 2017 (28 years) in the only Pathology Anatomy Laboratory in Togo.

Results: A total of 12 cases of suspected Basidiobolomycosis have been identified. The sex ratio (M/F) was 2. Read More

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http://dx.doi.org/10.1186/s13104-018-3777-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6137730PMC
September 2018
10 Reads

Epidemiological and Clinical Patterns of Kaposi Sarcoma: A 16-Year Retrospective Cross-Sectional Study from Yaoundé, Cameroon.

Dermatology 2018 11;234(5-6):198-204. Epub 2018 Sep 11.

Department of Internal Medicine and Specialties, Faculty of Medicine and Biomedical Sciences, University of Yaoundé I, Yaoundé, Cameroon.

Background: The burden of Kaposi sarcoma (KS) is increasing fast among HIV-infected populations, but the disease remains desperately underexplored in Cameroon, where the burden of HIV is high.

Methods: This is a retrospective cross-sectional study carried out over a period of 16 years (January 2001 to December 2016) at the HIV day care unit of the Central Hospital of Yaoundé, Cameroon. The diagnosis was based on clinical aspects and histological confirmation, and we used a preconstructed questionnaire for data collection through patients' electronic and physical files. Read More

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http://dx.doi.org/10.1159/000492175DOI Listing
March 2019
13 Reads

Various cutaneous tuberculosis with rare clinical manifestations: A case series.

Int J Mycobacteriol 2018 Jul-Sep;7(3):288-291

Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr. Hasan Sadikin General Hospital, Bandung, West Java, Indonesia.

Cutaneous tuberculosis (TB) has several clinical manifestations. The most common forms include cervical scrofuloderma and plaque type of lupus vulgaris (LV), otherwise the rare cases including inguinal scrofuloderma, ulcerative LV, and acute miliary TB. The highlight of this case series was to report various rare clinical manifestations of cutaneous TB. Read More

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http://dx.doi.org/10.4103/ijmy.ijmy_65_18DOI Listing
May 2019
8 Reads

A study of clinicopathological correlation of pruritic papular eruptions in HIV patients.

Indian J Sex Transm Dis AIDS 2018 Jan-Jun;39(1):44-49

Department of Skin and VD, Rajindra Hospital, GMC, Patiala, Punjab, India.

Context: Pruritic papular eruption (PPE) is a chronic eruption of papular and pruritic lesions of unknown etiology, symmetrically distributed over trunk and extremities. These are common cutaneous manifestations in HIV patients. It is an important cause of HIV-related morbidity. Read More

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http://dx.doi.org/10.4103/ijstd.IJSTD_10_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6111639PMC
September 2018
28 Reads

Secondary syphilis masquerading as lupus vulgaris in an HIV-infected patient: A diagnosis suggested by histology.

Int J STD AIDS 2018 12 31;29(14):1454-1456. Epub 2018 Aug 31.

Dermatology Unit, Department of Physiopathology and Transplantation, Università degli Studi di Milano, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.

We report a case of secondary syphilis mimicking lupus vulgaris in an HIV-infected patient. A 21-year-old Brazilian man presented with a two-month history of asymptomatic cutaneous lesions accompanied by fever and fatigue. Dermatological evaluation revealed an erythematous, crusted, large plaque on the neck with the 'apple jelly' sign on diascopy and two smaller scaly elements on the trunk and left palm. Read More

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http://dx.doi.org/10.1177/0956462418795590DOI Listing
December 2018
36 Reads

Non-cutaneous AIDS-associated Kaposi's sarcoma presenting as recurrent rectal abscesses.

BMJ Case Rep 2018 Aug 20;2018. Epub 2018 Aug 20.

Department of Surgery, NYU Langone Hospital-Brooklyn, Brooklyn, New York, USA.

Kaposi's sarcoma is a fatal disease that typically presents with cutaneous manifestations in immunocompromised individuals. There are a small number of documented cases where patients diagnosed with this disease present without cutaneous lesions. We present a 35-year-old man with recurrent rectal abscesses and fistula-in-ano, which required multiple drainage procedures. Read More

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http://dx.doi.org/10.1136/bcr-2018-225749DOI Listing
August 2018
58 Reads

Kaposi's sarcoma in persons living with HIV/AIDS: a case series in a tertiary referral hospital.

An Bras Dermatol 2018 Jul-Aug;93(4):524-528

Pathology Department, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém (PA), Brazil.

Background: Kaposi's sarcoma (KS) is a rare neoplasm with indolent progression. Since 1981, the Kaposi's sarcoma epidemic has increased as co-infection with HIV.

Objectives: The study aimed to identify the clinical and demographic characteristics and therapeutic approaches in HIV/AIDS patients in a regional referral hospital. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20186978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063130PMC
September 2018
20 Reads

[A rare and atypical cause of scrotal ulcerations].

Pan Afr Med J 2018 30;29:87. Epub 2018 Jan 30.

Service de Dermatologie-Vénéréologie, Hôpital Militaire d'Instruction Mohammed V, Rabat, Maroc.

Salmonelloses are bacterial infections of the faecal peril; they are endemic in some regions of the world. They can colonize almost any organ hematogenously, hence, severe forms may be observed. We report a case of typhoid fever in a 16-year old young adolescent with no medical history, sexually transmitted diseases or sexual intercourses, presenting with necrotic scrotal ulcerations evolving over the past 3 weeks in a context of fever, diarrhoea, weight loss and alteration of the general state. Read More

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http://dx.doi.org/10.11604/pamj.2018.29.87.14511DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5987151PMC
June 2018
15 Reads

Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review.

Clin Drug Investig 2018 Aug;38(8):653-671

Department of Clinical Experimental Oncology, Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy.

The process of finding new therapeutic indications for currently used drugs, defined as 'repurposing', is receiving growing attention. Chloroquine and hydroxychloroquine, with an original indication to prevent or cure malaria, have been successfully used to treat several infectious (HIV, Q fever, Whipple's disease, fungal infections), rheumatological (systemic lupus erythematosus, antiphospholipid antibody syndrome, rheumatoid arthritis, Sjögren's syndrome), and other immunological diseases. Indeed, they have anti-inflammatory, immunomodulating, anti-infective, antithrombotic, and metabolic effects. Read More

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http://link.springer.com/10.1007/s40261-018-0656-y
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http://dx.doi.org/10.1007/s40261-018-0656-yDOI Listing
August 2018
46 Reads

Real-time PCR applications for diagnosis of leishmaniasis.

Parasit Vectors 2018 05 2;11(1):273. Epub 2018 May 2.

Department of Biomolecular Sciences, University of Urbino Carlo Bo, via Saffi 2, 61029, Urbino, PU, Italy.

Leishmaniasis is a vector-borne disease caused by many Leishmania species, which can infect both humans and other mammals. Leishmaniasis is a complex disease, with heterogeneous clinical manifestations ranging from asymptomatic infections to lesions at cutaneous sites (cutaneous leishmaniasis), mucosal sites (mucocutaneous leishmaniasis) or in visceral organs (visceral leishmaniasis), depending on the species and host characteristics. Often, symptoms are inconclusive and leishmaniasis can be confused with other co-endemic diseases. Read More

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http://dx.doi.org/10.1186/s13071-018-2859-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5930967PMC
May 2018
12 Reads
3.430 Impact Factor

Non-primary nail-plate syphilis in an HIV-infected patient.

SAGE Open Med Case Rep 2018 28;6:2050313X18767229. Epub 2018 Mar 28.

Infectious Disease Clinic, Department of Medicine, University of Perugia, Perugia, Italy.

A 37-year-old Caucasian male, HIV-infected (CDC A2) in 2012 and on antiretroviral therapy, presented for a follow-up visit. On physical examination, a barely discernible light-colored macular rash was observed on the trunk, not involving the palms and soles. However, clear maculo-papular lesions were present over the proximal volar aspect of both forearms. Read More

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http://dx.doi.org/10.1177/2050313X18767229DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881977PMC
March 2018
21 Reads

[The changing face of medium-sized vasculitis].

Wiad Lek 2018;71(1 pt 1):64-72

Studia Doktoranckie, Zakład Farmakologii, Wydział Nauk o Zdrowiu, Uniwersytet Medyczny, Lublin.

Polyarteritis nodosa is a systemic necrotizing vasculitis which predominantly affects medium-sized arteries. It is a rare disease nowadays. Both the nomenclature and the classification of polyarteritis nodosa was amended several times in the past. Read More

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August 2018
17 Reads

Tegumentary leishmaniasis and coinfections other than HIV.

PLoS Negl Trop Dis 2018 03 1;12(3):e0006125. Epub 2018 Mar 1.

Department of Public Health, Institute of Tropical Medicine Antwerp, Antwerp, Belgium.

Background: Tegumentary leishmaniasis (TL) is a disease of skin and/or mucosal tissues caused by Leishmania parasites. TL patients may concurrently carry other pathogens, which may influence the clinical outcome of TL.

Methodology And Principal Findings: This review focuses on the frequency of TL coinfections in human populations, interactions between Leishmania and other pathogens in animal models and human subjects, and implications of TL coinfections for clinical practice. Read More

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http://dx.doi.org/10.1371/journal.pntd.0006125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5832191PMC
March 2018
27 Reads

Secondary pulmonary syphilis: Case report and review of literature.

Ann Dermatol Venereol 2018 Apr 17;145(4):278-287. Epub 2018 Feb 17.

Service de dermatologie, hôpital Emile-Muller, GHR Mulhouse-Sud Alsace, 20, avenue du Dr-René-Laennec, 68100 Mulhouse, France.

Introduction: Syphilis is a sexually transmitted disease that can affect numerous organs in its secondary or tertiary stages. We describe a case of secondary syphilis with pulmonary involvement and we present a literature review.

Patients And Methods: A 69-year-old male patient was admitted to hospital for dyspnoea and extended papular exanthema with palmoplantar involvement. Read More

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http://dx.doi.org/10.1016/j.annder.2017.11.015DOI Listing
April 2018
19 Reads

Mucocutaneous Manifestations of Infection by Histoplasma capsulatum in HIV-Negative Immunosuppressed Patients.

Actas Dermosifiliogr 2018 May 9;109(4):e27-e32. Epub 2018 Feb 9.

Servicio de Dermatología, Hospital Italiano de Buenos Aires, Ciudad Autónoma de Buenos Aires, Argentina.

Histoplasmosis is a systemic mycosis caused by the dimorphous fungus Histoplasma capsulatum (H. capsulatum). The fungus enters the body through the respiratory tract in the form of microconidia, which are transformed into intracellular yeast-like structures in the lungs before disseminating hematogenously. Read More

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http://dx.doi.org/10.1016/j.ad.2017.08.006DOI Listing
May 2018
5 Reads

Cutaneous Disseminated and Extracutaneous Sporotrichosis: Current Status of a Complex Disease.

J Fungi (Basel) 2017 Feb 10;3(1). Epub 2017 Feb 10.

Dermatology Service, Mycology Department, Hospital General de México "Eduardo Liceaga", Balmis 148, Colonia Doctores, CP: 03020. Cd. de México, México.

Sporotrichosis is an implantation or inoculation mycosis caused by species of complex; its main manifestations are limited to skin; however, cutaneous-disseminated, disseminated (visceral) and extracutaneous variants of sporotrichosis can be associated with immunosuppression, including HIV-AIDS, chronic alcoholism or more virulent strains. The most common extracutaneous form of sporotrichosis includes pulmonary, osteoarticular and meningeal. The laboratory diagnosis requires observing yeast forms and isolating the fungus; the two main causative agents are () and . Read More

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http://dx.doi.org/10.3390/jof3010006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715962PMC
February 2017
9 Reads

Correlation of mucocutaneous manifestations of HIV-infected patients in an ART center with CD4 counts.

Indian J Dent Res 2017 Sep-Oct;28(5):549-554

Department of Oral and Maxillofacial Pathology, Vokkaligara Sangha Dental College, Bengaluru, Karnataka, India.

Background: As the search for reliable clinical indicators for management of human immunodeficiency virus/AIDS continues, mucocutaneous manifestations of HIV are considered among key clinical indicators for prediction of underlying degree of immunosuppression, systemic opportunistic infections, and disease progression.

Objectives: (1) To study the prevalence of mucocutaneous manifestations in HIV-seropositive patients attending the ART center of our hospital (2) To correlate mucocutaneous manifestations with CD4 cell counts.

Materials And Methods: A total of 200 HIV-seropositive patients of adult age group visiting our hospital were included in the study. Read More

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http://dx.doi.org/10.4103/ijdr.IJDR_352_16DOI Listing
July 2018
9 Reads

Adrenal incidentaloma in a patient with HIV/AIDS.

J Surg Case Rep 2017 Jul 7;2017(7):rjx125. Epub 2017 Jul 7.

Department of General Surgery, Queen Elizabeth University Hospital, Glasgow, UK.

Human immunodeficiency virus (HIV) is well known to be associated with various neoplasms and opportunistic infections. Kaposi sarcoma (KS), associated with human herpes virus 8 (HHV8) infection, is the most common tumour in HIV positive patients and is also an acquired immune deficiency syndrome (AIDS) defining illness. Cutaneous manifestations are the most common presenting symptom; however, visceral involvement is also recognized. Read More

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http://dx.doi.org/10.1093/jscr/rjx125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570053PMC
July 2017
5 Reads

Histoplasmosis by var. duboisii Observed at the Laboratory of Pathological Anatomy of Lomé in Togo.

J Pathog 2017 18;2017:2323412. Epub 2017 Jul 18.

Department of Pathology, University Teaching Hospital of Lomé, Lomé, Togo.

Our study aimed to describe the epidemiological, clinical, and diagnostic aspects of African histoplasmosis in Togo through a descriptive and cross-sectional study on histological diagnosed African histoplasmosis in Pathology Department of Lomé from 2002 to 2016 (15 years). A total of 17 cases of African histoplasmosis were diagnosed. The sex ratio (M/F) was 1. Read More

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http://dx.doi.org/10.1155/2017/2323412DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5539941PMC
July 2017
95 Reads

Correlation of CD4 counts with clinical and histopathological findings in disseminated histoplasmosis: a 10-year retrospective study.

Int J Dermatol 2017 Sep 5;56(9):926-931. Epub 2017 Jul 5.

Department of Dermatovenerology, Medical Faculty Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia.

Background: Disseminated cutaneous histoplasmosis (DCH) is one of the manifestations of systemic histoplasmosis infection in HIV-positive patients. Interaction between host immune status and histoplasmosis infection is still poorly understood. It is thought that immune status, represented by CD4 counts, may be correlated with clinical and histopathological findings. Read More

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http://dx.doi.org/10.1111/ijd.13679DOI Listing
September 2017
13 Reads

Approach to skin and soft tissue infections in non-HIV immunocompromised hosts.

Curr Opin Infect Dis 2017 Aug;30(4):354-363

Section of Infectious Diseases and HIV Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA.

Purpose Of Review: Skin and soft tissue infections are frequent contributors to morbidity and mortality in the immunocompromised host. This article reviews the changing epidemiology and clinical manifestations of the most common cutaneous pathogens in non-HIV immunocompromised hosts, including patients with solid organ transplants, stem cell transplants, solid tumors, hematologic malignancies, and receiving chronic immunosuppressive therapy for inflammatory disorders.

Recent Findings: Defects in the innate or adaptive immune response can predispose the immunocompromised host to certain cutaneous infections in a predictive fashion. Read More

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http://dx.doi.org/10.1097/QCO.0000000000000378DOI Listing
August 2017
15 Reads

Unusual presentation of disseminated histoplasmosis in an immunocompetent patient.

Diagn Cytopathol 2017 Sep 4;45(9):848-850. Epub 2017 May 4.

Department of pathology, PGIMER, Dr. RML Hospital, New Delhi, India.

Disseminated histoplasmosis (DH) is a systemic granulomatous disease caused by the fungus Histoplasma capsulatum. This disease occurs mainly in immunocompromised individuals with CD 4 counts less than 200 cell/µL and is rarely noted in immunocompetent person. In India, this disease has been reported from several parts of the country of which most cases are from eastern India which is considered to be endemic for this disease. Read More

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http://dx.doi.org/10.1002/dc.23742DOI Listing
September 2017
9 Reads

Progressive cutaneous Cryptococcosis complicated with meningitis in a myasthenia gravis patient on long-term immunosuppressive therapy - a case report.

BMC Infect Dis 2017 04 26;17(1):311. Epub 2017 Apr 26.

Department of Dermatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Vietnam.

Background: Cryptococcosis is an opportunistic infection caused by the encapsulated yeast Cryptococcus neoformans and most remarkably manifests in HIV-infected individuals, especially in the settings of very low CD4 count. Development of cryptococcosis in HIV-uninfected individuals is exceedingly rare and usually signifies a marked immunodeficiency. Cryptococcosis in association with myasthenia gravis or thymoma has been previously documented in only very few cases in the literature. Read More

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http://dx.doi.org/10.1186/s12879-017-2415-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5406963PMC
April 2017
47 Reads

The Great Impostor: Transaminitis Masking the Coinfection of Syphilis and Human Immunodeficiency Virus.

Case Rep Med 2017 19;2017:2481961. Epub 2017 Mar 19.

St. John Providence Southfield Hospital, Southfield, MI, USA.

. The incidence of syphilis continues to rise in the United States over the past 15 years. This disease process is classified into stages and may present with a coinfection of Human Immunodeficiency Virus (HIV). Read More

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http://dx.doi.org/10.1155/2017/2481961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376408PMC
March 2017
16 Reads

Discoid Lupus and Human Immunodeficiency Virus: A Retrospective Chart Review to Determine the Prevalence and Progression of Co-occurrence of these Conditions at a Single Academic Center.

Indian J Dermatol 2017 Mar-Apr;62(2):226

Department of Dermatology, University of California, San Diego, CA, USA.

Context: Discoid lupus erythematosus (DLE) and human immunodeficiency virus (HIV) are both disorders of the immune system. The pathophysiology of these diseases varies greatly as DLE is characterized by an overactive immune system that attacks normal host cells, whereas HIV is characterized by an exogenous attack on the immune system that depletes it of key cell types. Although the reason is unknown, co-occurrence of DLE and HIV is rare. Read More

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http://dx.doi.org/10.4103/0019-5154.201750DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5363158PMC
April 2017
22 Reads

Cutaneous manifestations of subcutaneous and systemic fungal infections in tropical regions: a retrospective study from a referral center in southern Taiwan.

Int J Dermatol 2017 Jun 13;56(6):623-629. Epub 2017 Mar 13.

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: Deep cutaneous fungal infections, including subcutaneous mycoses and systemic fungal infection with cutaneous involvement, cause significant morbidity and mortality in light of increasing immunocompromised patients and global warming. Although a few studies reviewed deep fungal infections in temperate regions, a relevant study in tropical regions is lacking. We evaluated features of deep cutaneous fungal infections in southern Taiwan among the tropical regions. Read More

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http://dx.doi.org/10.1111/ijd.13497DOI Listing
June 2017
32 Reads