180,736 results match your criteria Cutaneous Manifestations Following Exposures to Marine Life


Cost-Effectiveness of Sentinel Lymph Node Biopsy for Head and Neck Cutaneous Squamous Cell Carcinoma.

J Surg Res 2019 Apr 17;241:15-23. Epub 2019 Apr 17.

Division of Surgical Oncology, Department of Surgery, Rutgers New Jersey Medical School, Newark, New Jersey. Electronic address:

Background: Sentinel lymph node biopsy (SLNB) has shown promise in identifying subclinical nodal metastasis in patients with high-risk cutaneous squamous cell carcinoma. However, low metastasis rates may indicate that performing such a procedure in all patients may be unnecessary and costly.

Materials And Methods: A decision model was developed to analyze costs and survival in patients with head and neck cutaneous squamous cell carcinoma based on their tumor and nodal metastasis staging and whether or not they received an SLNB. Read More

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http://dx.doi.org/10.1016/j.jss.2019.03.040DOI Listing

The impact of recent advances in lipidomics and redox lipidomics on dermatological research.

Free Radic Biol Med 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Medical University of Vienna, Austria; Christian Doppler Laboratory for the Biotechnology of Skin Aging, Vienna, Austria.

Dermatological research is a major beneficiary of the rapidly developing advances in lipid analytic technology and of bioinformatic tools which help to decipher and interpret the accumulating big lipid data. At its interface with the environment, the epidermis develops a blend of lipids that constitutes the epidermal lipid barrier, essential for the protection from water loss and entry of dangerous noxae. Apart from their structural role in the barrier, novel intra- and inter-cellular signaling functions of lipids and their oxidation products have been uncovered in most cutaneous cell types over the last decades, and the discovery rate has been boosted by the advent of high resolution and -throughput mass spectrometric techniques. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S08915849193015
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http://dx.doi.org/10.1016/j.freeradbiomed.2019.04.019DOI Listing
April 2019
1 Read

Rostrum: Itching as a systemic disease.

J Allergy Clin Immunol 2019 Apr 17. Epub 2019 Apr 17.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery and Miami Itch Center Miller School of Medicine University of Miami, Miami, FL. Electronic address:

Pruritus is a sensation that emanates from the skin and is transferred via peripheral nerve fibers to the central nervous system. It is easily understood that primary skin disorders such as atopic eczema, skin dryness, psoriasis, and urticaria can elicit pruritus. However certain systemic diseases can cause chronic pruritus that have significant impact on patients' quality of life. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S00916749193052
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http://dx.doi.org/10.1016/j.jaci.2019.04.005DOI Listing
April 2019
1 Read

Ingenol mebutate for mycosis fungoides.

Br J Dermatol 2019 Apr 20. Epub 2019 Apr 20.

Department of Dermatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Ingenol mebutate is a macrocyclic diterpene ester, naturally found in the sap of the Australian plant Euphorbia peplus, which proved efficacious for actinic keratosis. In clinical routine, we observed local improvement of MF upon application of ingenol mebutate in MF patients treated for coincidental actinic keratosis within direct proximity of/overlapping with MF skin lesions. Hence, the objective of this study was to assess the effect of topical ingenol mebutate on MF skin lesions. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/bjd.18018
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http://dx.doi.org/10.1111/bjd.18018DOI Listing
April 2019
5 Reads

Sunscreen or simulated sweat minimizes the impact of acute ultraviolet radiation on cutaneous microvascular function in healthy humans.

Exp Physiol 2019 Apr 20. Epub 2019 Apr 20.

Department of Kinesiology, The Pennsylvania State University, University Park, PA, 16802.

New Findings: What are the central questions of this study? Are UVR-induced increases in skin blood flow independent of skin erythema? Does broad-spectrum UVR exposure attenuate NO-mediated cutaneous vasodilation, and does sunscreen or sweat modulate this response? What are the main findings and their importance? Erythema and vascular responses to UVR are temporally distinct, and sunscreen prevents both responses. UVR exposure attenuates NO-mediated vasodilation in the cutaneous microvasculature; sunscreen or simulated sweat on the skin attenuate this response. Sun over-exposure may elicit deleterious effects on human skin that are separate from sunburn, and sunscreen or sweat on the skin may provide protection. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1113/EP087688
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http://dx.doi.org/10.1113/EP087688DOI Listing
April 2019
3 Reads

Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness.

Cancer Immunol Res 2019 Apr 19. Epub 2019 Apr 19.

Center for Personalized Cancer Therapy, Division of Blood and Marrow Transplantation, University of California San Diego Moores Cancer Center.

Advanced and metastatic squamous cell carcinomas (SCCs) are common and difficult-to-treat malignancies. We assessed 75 immunotherapy-treated SCC patients from a clinically annotated database of 2,651 patients, as well as 9,407 patients from a de-identified database for molecular features that might influence checkpoint blockade response. SCCs had higher tumor mutational burdens (TMB) than non-SCCs (P <0. Read More

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http://cancerimmunolres.aacrjournals.org/lookup/doi/10.1158/
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http://dx.doi.org/10.1158/2326-6066.CIR-18-0716DOI Listing
April 2019
1 Read

Kasabach-Merritt syndrome arising from a vascular fistula.

Am J Emerg Med 2019 Apr 10. Epub 2019 Apr 10.

Internal Medicine, San Camillo Hospital, Rome, Italy.

A 58-year-old woman presented with gum bleeding, hematuria, and cutaneous ecchymoses. Left hip replacement had been performed five years prior. The overall findings of our work-up were consistent with ongoing DIC triggered by the presence of an arterio-venous left femoral fistula. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S07356757193023
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http://dx.doi.org/10.1016/j.ajem.2019.04.013DOI Listing
April 2019
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Thrombin Preconditioning of Extracellular Vesicles Derived from Mesenchymal Stem Cells Accelerates Cutaneous Wound Healing by Boosting Their Biogenesis and Enriching Cargo Content.

J Clin Med 2019 Apr 18;8(4). Epub 2019 Apr 18.

Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.

The aim of this study was to determine the optimal preconditioning regimen for the wound healing therapeutic efficacy of mesenchymal stem cell (MSC)-derived extracellular vesicles (EVs). To this end, we compared various preconditioning regimens for both the quantitative and qualitative production of MSC-derived EVs, and their therapeutic efficacy for proangiogenic activity in vitro and cutaneous wound healing in vivo. After preconditioning with thrombin (40 U), HO (50 μM), lipopolysaccharide (1 μg/mL), or hypoxia (10% O), EV secretion was assessed quantitatively by measuring production per cell and protein quantification, and qualitatively by measuring a proteome profiler and an enzyme-linked immunosorbent assay (ELISA) contained within EVs. Read More

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http://dx.doi.org/10.3390/jcm8040533DOI Listing

Cutaneous nontuberculous mycobacteria infections: A retrospective case series of 78 patients from the Texas Gulf Coast region.

J Am Acad Dermatol 2019 Apr 16. Epub 2019 Apr 16.

Department of Dermatology, University of Texas Medical Branch, Galveston, TX.

Background: The incidence of cutaneous nontuberculous mycobacteria (NTM) infections is increasing. These infections are a diagnostic and therapeutic challenge.

Objective: We aimed to investigate clinical features, diagnosis and management of cutaneous NTM infections. Read More

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http://dx.doi.org/10.1016/j.jaad.2019.04.022DOI Listing

Light and transmission electron microscopic structure of skin glands and dermal scales of a caecilian amphibian Gegeneophis ramaswamii, with a note on antimicrobial property of skin gland secretion.

Microsc Res Tech 2019 Apr 19. Epub 2019 Apr 19.

Department of Animal Science, Central University of Kerala, Kasaragod, Kerala, India.

Amphibian skin secretions contain a variety of bioactive compounds that are involved in diverse roles such as communication, homeostasis, defence against predators, pathogens, and so on. Especially, the caecilian amphibians possess numerous cutaneous glands that produce the secretory material, which facilitate survival in their harsh subterranean environment. Inspite of the fact that India has a fairly abundant distribution of caecilian amphibians, there has hardly been any study on their skin and its secretion. Read More

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http://dx.doi.org/10.1002/jemt.23276DOI Listing

A pilot study of human mesenchymal stem cells from visceral and sub-cutaneous fat tissue and their differentiation to osteogenic phenotype.

Eur Rev Med Pharmacol Sci 2019 Apr;23(7):2924-2934

Department of Clinical and Experimental Medicine, University of Foggia, Foggia, Italy.

Objective: To evaluate the different behavior of two different human adult adipocytes derived stem cells (hASCs) during proliferation and osteogenic differentiation.

Patients And Methods: Human adult adipocytes stem cells (hAT-SCs) from visceral (hAV-SCs) and subcutaneous (hAS-SCs) sites were obtained after surgery procedures of seven patients. All samples were fully investigated and the different proliferation rates were evaluated. Read More

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http://dx.doi.org/10.26355/eurrev_201904_17572DOI Listing

Dynamic expression of glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1 in the mouse spinal cord dorsal horn under pathological pain states.

Neurol Res 2019 Apr 19:1-11. Epub 2019 Apr 19.

a Department of Physiology, Laboratory of Pain Neurobiology, Ribeirão Preto School of Medicine , University of São Paulo , Ribeirão Preto , Brazil.

Objective: Animal models of chronic pain have demonstrated that glial cells are promising target for development of analgesic drugs. However, preclinical studies on glial response under chronic pain conditions vary depending on the cellular markers, the species used, the experimental design and model. Therefore, we investigate the expression profile of GFAP and Iba-1 during the behavioral manifestation of sensory disorder in inflammatory and neuropathic pain models. Read More

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http://dx.doi.org/10.1080/01616412.2019.1603804DOI Listing

A novel player in the field: Merkel disk in touch, itch, and pain.

Exp Dermatol 2019 Apr 18. Epub 2019 Apr 18.

Department of Anesthesiology, The Center for the Study of Itch, Washington University School of Medicine, St. Louis, MO, 63110, United States.

Mammalian skin, comprising both hairy and glabrous skin, is innervated by various types of low-threshold mechanoreceptors (LTMRs), which renders skin into a mechanosensitive organ [1]. Based on the degree of axonal myelination and conduction velocity, LTMRs are further divided into C-, Aδ- and Aβ-LTMRs. Electrophysiological recordings from those LTMRs have revealed unique action potential firing patterns upon discriminative mechanical stimuli. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/exd.13945
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http://dx.doi.org/10.1111/exd.13945DOI Listing
April 2019
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Evaluation of Demodex mite viability using motility and scattered light intensity.

Exp Appl Acarol 2019 Apr 19. Epub 2019 Apr 19.

Charles Institute of Dermatology, University College Dublin, Dublin, Ireland.

Demodex mites have been suggested to have a role in various cutaneous and ocular disorders pathogenesis, such as rosacea or blepharitis. Evaluation of potential treatments with anti-Demodex effects is difficult because the viability of living mites needs to be evaluated during their exposure to the agent being tested. Mite viability is currently based solely on their observed movement. Read More

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http://dx.doi.org/10.1007/s10493-019-00358-4DOI Listing

Prevalence and Correlates of Vitamin D Deficiency in a Sample of 290 Inpatients With Mental Illness.

Front Psychiatry 2019 29;10:167. Epub 2019 Mar 29.

Department of Molecular and Developmental Medicine, University of Siena, Siena, Italy.

Vitamin D inadequacy or deficiency (VDID) has been reported in a high percentage of otherwise healthy individuals. Factors that may contribute to the high prevalence of VDID in people with mental disorders include diet low in vitamin D, poor sunlight exposure, decrease in cutaneous vitamin D synthesis, intake of certain medications, poor mobility, excessive alcohol intake, and tobacco smoking. VDID has been correlated to a host of adverse conditions, including rickets, osteoporosis, osteomalacia, muscle diseases, depression, cognitive dysfunction, and even certain cancers. Read More

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https://www.frontiersin.org/article/10.3389/fpsyt.2019.00167
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http://dx.doi.org/10.3389/fpsyt.2019.00167DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6455075PMC
March 2019
3 Reads

Nasopharyngeal carcinoma with cutaneous metastases.

Eur Ann Otorhinolaryngol Head Neck Dis 2019 Apr 15. Epub 2019 Apr 15.

Department of radiotherapy, Farhat Hached hospital, Sousse, Tunisia.

Introduction: Cutaneous metastases from nasopharyngeal carcinoma are extremely rare and associated with a poor prognosis.

Case Reports: We retrospectively reviewed 820 patients with nasopharyngeal carcinoma treated over a 20-year period in the radiotherapy department of Farhat Hached hospital in Sousse and Ibn Khaldoun Medical centre, Hammam Sousse. Two of these patients presented cutaneous metastases. Read More

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http://dx.doi.org/10.1016/j.anorl.2019.04.005DOI Listing
April 2019
2 Reads

Iatrogenic pediatric hydroxocobalamin overdose.

Am J Emerg Med 2019 Apr 10. Epub 2019 Apr 10.

University of Washington, Department of Emergency Medicine, United States of America.

Introduction: Hydroxocobalamin, a precursor molecule to vitamin B12, has emerged as the preferred empiric treatment for patients rescued from enclosed-space fires with concern for inhalational injury and potential concomitant cyanide toxicity. Limited data exist on the effects of hydroxocobalamin toxicity, particularly in pediatric patients.

Case Report: We report a case of a healthy three-year old girl who was rescued from an apartment fire and electively intubated by prehospital providers. Read More

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http://dx.doi.org/10.1016/j.ajem.2019.04.012DOI Listing

Perineural Invasion in Cutaneous Squamous Cell Carcinoma.

Actas Dermosifiliogr 2019 Apr 15. Epub 2019 Apr 15.

Servicio de Dermatología, Instituto Valenciano de Oncología, Valencia, España.

Cutaneous squamous cell carcinoma is sometimes characterized by an increased risk of locoregional recurrence and occasionally distant metastasis. Several clinical and pathological factors, including perineural invasion, have been shown to have prognostic value in this setting. Perineural invasion, that is, the spread of tumor cells into the space surrounding a nerve, is usually an incidental finding. Read More

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http://dx.doi.org/10.1016/j.ad.2018.10.006DOI Listing

Efficacy of miltefosine compared with glucantime for the treatment of cutaneous leishmaniasis: a systematic review and meta-analysis.

Epidemiol Health 2019 Mar 31:e2019011. Epub 2019 Mar 31.

Department of Epidemiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Objectives: The objective of this paper is a systematic review and meta-analysis of clinical trials that compared the efficacy of miltefosine and glucantime in the treatment of Cutaneous leishmaniasis (CL).

Methods: We searched the following databases: Cochrane, PubMed, Embase, Scopus, Web of Science, ProQuest, CENTRAL, ICTRP, Sid, irandoc, magiran, and clinicaltrials.gov. Read More

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http://dx.doi.org/10.4178/epih.e2019011DOI Listing

Cutaneous perfusion of the human lactating breast: a pilot study with laser Doppler perfusion monitoring.

Physiol Meas 2019 Apr 18. Epub 2019 Apr 18.

Biomedical Photonic Imaging, University of Twente, Drienerlolaan 5, building Zuidhorst 256, Enschede, Overijssel, 7500AE, NETHERLANDS.

<i>Objective</i>: Knowledge on the hemodynamics of the human lactating breast contributes to our understanding of lactation physiology, as well as the development and management of breastfeeding problems. The objective of this pilot study was to investigate whether laser Doppler perfusion monitoring (LDPM) can be employed to measure physiological changes in mammary cutaneous perfusion during milk extraction. <i>Approach</i>: We evaluated mammary cutaneous perfusion with LDPM in 9 lactating women during milk extraction in both the ipsilateral ('milk extracting') and contralateral ('passive') breast. Read More

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http://dx.doi.org/10.1088/1361-6579/ab1ad7DOI Listing
April 2019
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Post-irradiation recovery time strongly influences fractional laser-facilitated skin absorption.

Int J Pharm 2019 Apr 15;564:48-58. Epub 2019 Apr 15.

Research Center for Food and Cosmetic Safety and Research Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Kweishan, Taoyuan, Taiwan; Pharmaceutics Laboratory, Graduate Institute of Natural Products, Chang Gung University, Kweishan, Taoyuan, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Kweishan, Taoyuan, Taiwan. Electronic address:

Fractional CO laser treatment has been used in some clinical trials to promote topical drug delivery. Currently, there is no standard for laser settings to achieve a feasible therapy. The cutaneous recovery following laser treatment and its influence on drug absorption have not been well explored. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S03785173193030
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http://dx.doi.org/10.1016/j.ijpharm.2019.04.043DOI Listing
April 2019
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Oxidative stress-induced HMGB1 release from melanocytes: a paracrine mechanism underlying the cutaneous inflammation in vitiligo.

J Invest Dermatol 2019 Apr 15. Epub 2019 Apr 15.

Department of Dermatology, Xijing Hospital, Fourth Military Medical University, 127 Changle West Road, Xi'an, shaanxi, 710032, China. Electronic address:

Vitiligo is a cutaneous depigmentation disorder caused by the destruction of epidermal melanocytes. The generation and the skin infiltration of autoreactive CD8 cytotoxic T cells triggered by oxidative stress play a critical role in vitiligo. High-mobility group protein B1 (HMGB1) is a classic damage-associated molecular pattern (DAMP) molecule with strong proinflammatory effects in inflammatory reactions. Read More

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http://dx.doi.org/10.1016/j.jid.2019.03.1148DOI Listing

Leishmania infantum LeIF and its recombinant polypeptides induce the maturation of dendritic cells in vitro: an insight for dendritic cells based vaccine.

Immunol Lett 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Molecular Epidemiology and Experimental Pathology, Institut Pasteur de Tunis, Université Tunis El Manar, 13 Place Pasteur, BP 74, 1002 Tunis-Belvedère, Tunisia. Electronic address:

We previously showed that recombinant Leishmania infantum eukaryotic initiation factor (LieIF) was able to induce the secretion of cytokines IL-12, IL-10 and TNF-α by human monocytes. In this study, we explored in vitro the potential of LieIF to induce phenotypic maturation and functional differentiation of murine bone - marrow derived dendritic cells (BM-DCs). Moreover, in order to identify potential immunnomodulatory regions of LieIF, eight recombinant overlapping protein fragments covering the whole amino acid sequence ofprotein; were constructed and assessed in vitro for their ability to induce maturation of BM-DCs. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01652478183041
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http://dx.doi.org/10.1016/j.imlet.2019.04.001DOI Listing
April 2019
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Automated in vivo screen in zebrafish identifies clotrimazole as targeting a metabolic vulnerability in a melanoma model.

Dev Biol 2019 Apr 15. Epub 2019 Apr 15.

Laboratory of Experimental Cancer Biology, CIBIO Department, University of Trento, Via Sommarive 9, 38123 Povo TN, Italy. Electronic address:

Therapeutic approaches for cutaneous melanoma are flourishing, but despite promising results, there is an increasing number of reported primary or secondary resistance to the growing sets of drugs approved for therapy in the clinics. Combinatorial approaches may overcome resistance, as they may tackle specific weaknesses of melanoma cells, not sufficient on their own, but effective in combination with other therapies. The transgenic zebrafish line kita:ras develops melanoma with high frequency. Read More

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http://dx.doi.org/10.1016/j.ydbio.2019.04.005DOI Listing

Association of Anti-Programmed Cell Death 1 Cutaneous Toxic Effects With Outcomes in Patients With Advanced Melanoma.

JAMA Oncol 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1001/jamaoncol.2019.0046DOI Listing

Racial/ethnic differences in experimental pain sensitivity and associated factors - Cardiovascular responsiveness and psychological status.

PLoS One 2019 18;14(4):e0215534. Epub 2019 Apr 18.

Department of Pain and Translational Symptom Science, University of Maryland School of Nursing, Baltimore, Maryland, United States of America.

This study evaluated the contributions of psychological status and cardiovascular responsiveness to racial/ethnic differences in experimental pain sensitivity. The baseline measures of 3,159 healthy individuals-non-Hispanic white (NHW): 1,637, African-American (AA): 1,012, Asian: 299, and Hispanic: 211-from the OPPERA prospective cohort study were used. Cardiovascular responsiveness measures and psychological status were included in structural equation modeling based mediation analyses. Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0215534PLOS
April 2019
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Utilization of Laser Therapy During Pregnancy: A Systematic Review of the Maternal and Fetal Effects Reported From 1960 to 2017.

Dermatol Surg 2019 Apr 16. Epub 2019 Apr 16.

Skin Laser & Surgery Specialists of NY and NJ, New York, New York.

Background: Due to concerns regarding maternal and fetal safety and the absence of evidence to the contrary, laser treatment during pregnancy has traditionally been limited to situations of absolute necessity.

Objective: This review seeks to examine the available evidence to determine the safety of laser therapy during pregnancy.

Methods: Medical databases were searched for relevant reports from all specialties regarding the use of lasers during pregnancy from 1960 to 2017. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001912DOI Listing
April 2019
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Presumed Choroidal Granuloma Annulare Mimicking Choroidal Lymphoma.

Ophthalmic Surg Lasers Imaging Retina 2019 Apr;50(4):e128-e132

A 71-year-old white male presented with unilateral trace vitreous cell and hypopigmented choroidal lesions, corresponding to hyporeflective areas on optical coherence tomography (OCT). The lesions grew slowly during a period of 2.5 years, but the patient remained asymptomatic. Read More

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https://www.healio.com/doiresolver?doi=10.3928/23258160-2019
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http://dx.doi.org/10.3928/23258160-20190401-18DOI Listing
April 2019
1 Read

Hydroa vacciniforme: a distinctive form of Epstein-Barr virus-associated T-cell lymphoproliferative disorders.

Eur J Dermatol 2019 Feb;29(1):21-28

Department of Dermatology, Kawasaki Medical School,, Department of Dermatology, Kawasaki Medical School General Medical Center, Okayama, Japan.

Hydroa vacciniforme (HV) is a cutaneous subset of Epstein-Barr virus (EBV)-associated T/NK lymphoproliferative disorders (LPDs). Our previous case series study clearly showed a clinical spectrum of EBV-associated T/NK LPDs including HV, hypersensitivity to mosquito bites (HMB), chronic active EBV infection (CAEBV), and hemophagocytic lymphohistiocytosis (HLH). Patients with HV are divided into two groups: a benign subtype designated "classic HV" (cHV) and more serious systemic HV (sHV), also called "HV-like LPD" in the 2017 World Health Organization (WHO) classification. Read More

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http://dx.doi.org/10.1684/ejd.2018.3490DOI Listing
February 2019

Staging of primary cutaneous follicle centre B-cell lymphoma: bone marrow biopsy, CD10, BCL2 and t(14;18) are not relevant prognostic factors.

Eur J Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Dermatologie, Institut Universitaire du Cancer de Toulouse, Université Paul Sabatier, Hôpital Larrey et Oncopole, Toulouse.

Background: There is a certain degree of controversy as to whether bone marrow biopsy is required during the staging procedures for primary cutaneous follicle centre B-cell lymphoma (PCFCCL).

Objectives: Firstly, to determine extra-cutaneous involvement at initial diagnosis, in particular, based on bone marrow biopsy, and secondly, evaluate the phenotypic features associated with extra-cutaneous involvement during follow-up (in particular, the predictive value of BCL2 and CD10 coexpression and identification of t[14;18] in skin lesions, as well as bone marrow biopsy involvement at initial staging) in a cohort of patients with PCFCCL.

Materials & Methods: A bicentric retrospective study was established to investigate 75 cases of PCFCCL, for which 44 bone marrow biopsies were performed. Read More

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http://dx.doi.org/10.1684/ejd.2018.3489DOI Listing
April 2019
1 Read

The relationship between skin rash and outcome in dengue.

J Vector Borne Dis 2018 Oct-Dec;55(4):310-314

Department of General Medicine, Christian Medical College, Vellore, Tamil Nadu, India.

Background & Objectives: Dengue fever (DF) is a common cause of acute febrile illness. Skin involvement is seen in more than half of the patients. This study was aimed to compare the clinical profile and outcome in DF patients with or without skin involvement. Read More

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http://dx.doi.org/10.4103/0972-9062.256567DOI Listing
April 2019
2 Reads

Modeling spatial distribution of as the main reservoir host of zoonotic cutaneous leishmaniasis in northeastern Iran.

J Vector Borne Dis 2018 Oct-Dec;55(4):297-304

Department of Epidemiology and Biostatistics, Kerman University of Medical Sciences, Kerman, Iran.

Background & Objectives: Zoonotic cutaneous leishmaniasis (ZCL) is among the most endemic zoonotic diseases in Golestan Province of Iran. The aim of this study was to find the high risk areas of this infection by considering the distribution of reservoirs and human infection.

Methods: A cross-sectional study was conducted, in which Rhombomys opimus (Gerbils) were captured from different collection sites across the Golestan Province, Iran. Read More

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http://dx.doi.org/10.4103/0972-9062.256565DOI Listing
April 2019
1 Read

Intraparenchymal application of mature B lymphocytes improves structural and functional outcome after contusion traumatic brain injury.

J Neurotrauma 2019 Apr 18. Epub 2019 Apr 18.

Massachusetts General Hospital, Pediatric Critical Care Medicine, Boston, Massachusetts, United States ;

Cerebral contusion causes neurological dysfunction mediated in part by inflammatory responses to injury. B lymphocytes are dynamic regulators of the immune system that have not been systematically studied in traumatic brain injury (TBI). We showed previously that topically-applied mature B cells have immuno-modulatory properties and strongly promote tissue regeneration, including cutaneous nerve growth, in acute and chronic skin wounds. Read More

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http://dx.doi.org/10.1089/neu.2018.6368DOI Listing

Activated cytotoxic T cells within zoonotic cutaneous leishmaniasis lesions.

Immun Inflamm Dis 2019 Apr 17. Epub 2019 Apr 17.

Laboratory of Transmission, Control and Immunobiology of Infections, Pasteur Institute of Tunis, Tunis, Tunisia.

Introduction: Zoonotic cutaneous leishmaniasis (ZCL), due to infection by Leishmania (L). major, is characterized by polymorphic clinical manifestations which could be attributed to the host's immune response. In this study we investigated the involvement of cytotoxic cells on the outcome of the disease. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/iid3.240
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http://dx.doi.org/10.1002/iid3.240DOI Listing
April 2019
1 Read

NAV2 facilitates invasion of cutaneous melanoma cells by targeting SNAI2 through the GSK-3β/β-catenin pathway.

Arch Dermatol Res 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People's Republic of China.

Previous studies have identified neuron navigator 2(NAV2) as an oncogene in several human tumors. However, the NAV2 gene expression changes and its role in the pathogenesis of cutaneous melanoma have not been clearly illustrated. Further investigations of NAV2 in cutaneous melanoma may provide new mechanistic insight and treatment strategy for this disease. Read More

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http://dx.doi.org/10.1007/s00403-019-01909-wDOI Listing

BRAF mutation status might contribute an effect on both disease-free and overall survival in stage III cutaneous melanomas treated with intermediate dose interferon-alpha.

Cancer Chemother Pharmacol 2019 Apr 17. Epub 2019 Apr 17.

Department of Medical Oncology, Institute of Oncology, University of Istanbul, Capa, 34390, Istanbul, Turkey.

Purpose: The interaction between interferon treatment and BRAF mutation status among melanoma patients have yet to be evaluated. The present study aims to assess the intermediate dose interferon (IDI) in stage III melanoma patients with respect to BRAF mutation status.

Methods: A total of 46 adult lymph node-positive primary skin melanoma patients (23 BRAF-mutant and 23 BRAF-wild) with available information on the mutational status of the oncogene BRAF V600E were included in the analysis. Read More

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http://dx.doi.org/10.1007/s00280-019-03842-1DOI Listing

Effects of Light Touch on Balance in Patients with Stroke.

Open Med (Wars) 2019 9;14:259-263. Epub 2019 Apr 9.

Department of Physical Therapy, College of Health Science, Gachon University, Incheon, Republic of Korea, 191 Hambangmoe-ro, Yeonsu-gu, Inchon, 406-799, Republic of Korea.

Light touch is the combination of cutaneous and kinesthetic inputs. The literature suggests that light touch compensates for a reduced amount of center of pressure information in older peoples, blind subjects and patients with neurological disorder. This study investigated the effects of light touch applied to an external bar, on the postural sway in individuals with hemiparetic stroke. Read More

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http://www.degruyter.com/view/j/med.2019.14.issue-1/med-2019
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http://dx.doi.org/10.1515/med-2019-0021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6463820PMC
April 2019
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Atypical blastomycosis in a pregnant woman.

Int J Womens Dermatol 2019 Jun 29;5(2):131-133. Epub 2018 Dec 29.

University of Vermont College of Medicine.

Blastomycosis is a rare fungal infection that frequently involves the skin. Atypical presentations are important to identify, especially in pregnant patients, to initiate appropriate therapy and prevent complications. Uniquely, we describe a case of atypical blastomycosis that presented with painful cutaneous abscesses in a pregnant patient, with dissemination to the central nervous system. Read More

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http://dx.doi.org/10.1016/j.ijwd.2018.11.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451747PMC

Estrogen-deficient skin: The role of topical therapy.

Int J Womens Dermatol 2019 Jun 15;5(2):85-90. Epub 2019 Mar 15.

Montefiore Medical Center, Department of Medicine, Division of Dermatology, Bronx, New York.

Menopause is a major turning point in a woman's life that is characterized by declining ovarian function and decreased serum estrogen levels. The resulting hormonal changes particularly affect the skin, with postmenopausal symptoms such as loss of structural architecture and increased propensity to damage becoming rapidly noticeable. Interestingly, studies have shown that estrogen deprivation in postmenopausal conditions accelerates many skin changes, including dryness, atrophy, fine wrinkling, and poor wound healing. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S23526475193000
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http://dx.doi.org/10.1016/j.ijwd.2019.01.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451761PMC
June 2019
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Pembrolizumab-induced sarcoid granulomatous panniculitis and bullous pemphigoid in a single patient.

Clin Case Rep 2019 Apr 11;7(4):773-775. Epub 2019 Mar 11.

Department of Dermatology Peter MacCallum Cancer Centre Melbourne Victoria Australia.

Pembrolizumab is an immune checkpoint inhibitor with antitumor activity in other organ malignancies. We present this case -demonstrating multiple inflammatory adverse events associated with Pembrolizumab (in a single patient), in order to increase awareness and facilitate earlier identification of the wide-ranging cutaneous side effects associated with immunotherapy. Read More

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http://dx.doi.org/10.1002/ccr3.2090DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452463PMC

Primary cutaneous CD4+ small-/medium-sized T-cell lymphoproliferative disorder: A case report.

Clin Case Rep 2019 Apr 22;7(4):703-706. Epub 2019 Feb 22.

Department of Dermatology and Venereology Medical University of Lodz Lodz Poland.

Primary cutaneous CD4+ small-/medium-sized T-cell lymphoproliferative disorder is usually characterized by nodules and plaques affecting the upper part of the body. The present case presented with a large, single tumor located on a lower extremity. The patient did not respond to surgical therapy but responded to cyclophosphamide, methotrexate, and radiotherapy. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ccr3.2018
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http://dx.doi.org/10.1002/ccr3.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452474PMC
April 2019
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A case of palisaded neutrophilic granulomatous dermatitis with subsequent development of chronic myelomonocytic leukemia.

Clin Case Rep 2019 Apr 20;7(4):695-698. Epub 2019 Feb 20.

2nd Department of Dermatology and Venereology, General Hospital "Papageorgiou", Medical School Aristotle University of Thessaloniki Thessaloniki Greece.

Palisaded neutrophilic granulomatous dermatitis is a cutaneous marker of a systemic disease. Clinicians' goal should be directed toward determining an underlying condition. Even if the initial investigation is inconclusive, it may be necessary that some tests are repeated, since a serious underlying disease could be revealed in the course of time. Read More

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http://dx.doi.org/10.1002/ccr3.2072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452460PMC

Cutaneous lymphangioma circumscriptum: The relevance of clinical, dermoscopic, radiological, and histological assessments.

Clin Case Rep 2019 Apr 17;7(4):612-615. Epub 2019 Feb 17.

Dermatology Service of Clinics Hospital of Uberlandia (HCU/UFU) Federal University of Uberlandia (UFU) Uberlândia Brazil.

Cutaneous lymphangioma circumscriptum (CLC) is a rare congenital malformation of the superficial cutaneous lymphatic ducts. Case report: A 7-year-old boy presented plaque with grouped vesicles resembling a "frog spawn" on the upper left thigh, since 4 months old. The clinical, dermatoscopic and histopathological correlation is of great importance. Read More

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http://dx.doi.org/10.1002/ccr3.2007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6452527PMC

[Lamotrigine induced hypersensitivity syndrome in children: a case report].

Authors:
N X Cui X P Zhu

Beijing Da Xue Xue Bao Yi Xue Ban 2019 Apr;51(2):356-358

Department of Neonatology, Children's Hospital of Soochow University, Suzhou 215025, Jiangsu, China.

Drug induced hypersensitivity syndrome (DIHS) is often manifested as severe systemic drug trans-reactions characterized by acute and extensive skin lesions (mostly measles-like rash), fever, enlargement of lymph nodes, multiple organ involvement (hepatitis, nephritis, and pneumonia), eosinophilia and mononucleosis,within 2-6 weeks of the application of sensitizing drugs. In the early stage of the lesion, macular papules or erythema multiforme were common, and in severe cases, exfoliative dermatitis, Stevens-Johnson syndrome and toxic epidermal necrolysis were also common. Most of them developed after taking allergic drugs for 2-6 weeks (average: 3 weeks). Read More

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April 2019
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Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors.

Proc Natl Acad Sci U S A 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115;

Innocuous mechanical stimuli acting on the skin are detected by sensory neurons, known as low-threshold mechanoreceptors (LTMRs). LTMRs are classified based on their response properties, action potential conduction velocity, rate of adaptation to static indentation of the skin, and terminal anatomy. Here, we report organizational properties of the cutaneous and central axonal projections of the five principal hairy skin LTMR subtypes. Read More

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http://dx.doi.org/10.1073/pnas.1901378116DOI Listing
April 2019
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Polymeric micelle nanocarriers for targeted epidermal delivery of the hedgehog pathway inhibitor vismodegib: formulation development and cutaneous biodistribution in human skin.

Expert Opin Drug Deliv 2019 Apr 17. Epub 2019 Apr 17.

a School of Pharmaceutical Sciences , University of Geneva & University of Lausanne , 1 Rue Michel Servet, 1211 Geneva , Switzerland.

Background: The aim was to investigate cutaneous delivery and biodistribution of the hedgehog pathway inhibitor, vismodegib (VSD), indicated for basal cell carcinoma (BCC), from polymeric micelle formulations under infinite/finite dose conditions.

Methods: VSD-loaded micelles were characterized for drug content, particle size and shape; a micelle gel was characterized for its rheological behavior. Cutaneous deposition and biodistribution of VSD were determined using porcine and human skin in vitro with quantification by UHPLC-MS/MS. Read More

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http://dx.doi.org/10.1080/17425247.2019.1609449DOI Listing
April 2019
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Identification of dehydroxy isoquine and isotebuquine as promising antileishmanial agents.

Arch Pharm (Weinheim) 2019 Apr 17:e1800281. Epub 2019 Apr 17.

Laboratorio de Ingeniería Genética, Instituto de Biomedicina, Facultad de Medicina, Universidad Central de Venezuela, Caracas, Venezuela.

Traditional antimalarial drugs based on 4-aminoquinolines have exhibited good antiproliferative activities against Leishmania parasites; however, their clinical use is currently limited. To identify new 4-aminoquinolines to combat American cutaneous leishmaniasis, we carried out a full in vitro evaluation of a series of dehydroxy isoquines and isotebuquines against two Leishmania parasites such as Leishmania braziliensis and Leishmania mexicana. First, the antiproliferative activity of the quinolines was studied against the promastigote forms of L. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1002/ardp.2018002
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http://dx.doi.org/10.1002/ardp.201800281DOI Listing
April 2019
2 Reads

Interrater Reliability of Clinical Grading Measures for Cutaneous Chronic Graft-vs-Host Disease.

JAMA Dermatol 2019 Apr 17. Epub 2019 Apr 17.

Department of Dermatology, Duke University, Durham, North Carolina.

Importance: Cutaneous chronic graft-vs-host disease (cGVHD) is common after allogeneic hematopoietic stem cell transplant and is often associated with poor patient outcomes. A reliable and practical method for assessing disease severity and response to therapy among these patients is urgently needed.

Objective: To evaluate the interrater agreement and reliability of skin-specific and range of motion (ROM) variables of the 2014 National Institutes of Health (NIH) response criteria for cGVHD and a skin sclerosis grading scale (SSG). Read More

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http://archderm.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamadermatol.2018.5459DOI Listing
April 2019
2 Reads