200,894 results match your criteria Cutaneous Manifestations Following Exposures to Marine Life

MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.

Pain 2021 Jul;162(7):2120-2131

Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States.

Abstract: Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, nonpeptidergic C fibers also respond to mechanical input in the innocuous range, so the degree to which they contribute to nociception remains unclear. To address this gap, we investigated the function of nonpeptidergic afferents using the MrgprdCre allele. Read More

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Global Reach 2018: nitric oxide-mediated cutaneous vasodilation is reduced in chronic, but not acute, hypoxia independently of enzymatic superoxide formation.

Free Radic Biol Med 2021 Jun 12. Epub 2021 Jun 12.

Department of Kinesiology, University of Texas at Arlington, Arlington, TX, USA. Electronic address:

We tested the hypotheses that 1) cutaneous microvascular function is impaired by acute normobaric and chronic hypobaric hypoxia and 2) that the superoxide free radical (via NADPH oxidase or xanthine oxidase) contributes to this impairment via nitric oxide (NO) scavenging. Local heating-induced cutaneous hyperemia (39°C) was measured in the forearm of 11 male lowlanders at sea level (SL) and following 14-18 days at high altitude (HA; 4340 m in Cerro de Pasco, Peru), and compared to 11 highlanders residing permanently at this elevation. Cutaneous vascular conductance (CVC; laser-Doppler flux/mean arterial pressure) was not different during 39°C [control site: 73 (19) vs. Read More

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Localized Cutaneous Reaction to a mRNA COVID-19 Vaccine.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Department of Dermatology, Wayne State University, Detroit, Michigan, USA.

The corona virus disease (COVID-19) is a novel disease that can lead to fatal outcomes in infected individuals. Messenger RNA (mRNA) vaccines are two of the three Food and Drug Administration (FDA) approved vaccines in the United States (US) to date. Disclosed side effects by the Centers for Disease Control and Prevention (CDC) included tiredness, headache, muscle pain, chills, fever, and nausea. Read More

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Cutaneous long covid.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

NESMOS Dermatology Department, Sapienza University of Rome, Rome, Italy.

Researchers have defined the term 'long covid' as the inability to recover from the symptoms associated to COVID-19 even after months from the peak of the disease . Fatigue, myalgia, chest pain, shortness of breath, cardiac problems, like post-viral myocarditis, and diarrhea have been reported . Recently, Huang et al. Read More

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Comparison of injectable filler locations in men and women: An age-matched case analysis.

J Cosmet Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Laser & Skin Surgery Center of New York, New York, NY, USA.

In recent years, the popularity of fillers has risen significantly. Traditionally, women have undergone the vast majority of cosmetic procedures, but men have steadily shown increasing interest. Recently, significant research has been dedicated to understanding the anatomic differences between male and female facial structures and their clinical aesthetic implications, especially for filler placement. Read More

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Association of vaping with decreased vascular endothelial growth factor expression and decreased microvessel density in cutaneous wound healing tissue in rats.

Wound Repair Regen 2021 Jun 15. Epub 2021 Jun 15.

Boston University School of Medicine, Boston, Massachusetts, USA.

Vaping is suggested to be a risk factor for poor wound healing akin to smoking. However, the molecular and histologic mechanisms underlying this postulation remain unknown. Our study sought to compare molecular and histologic changes in cutaneous flap and non-flap tissue between vaping, smoking and control cohorts. Read More

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Combined surgical and endovascular treatment for spinal arteriovenous fistula associated with Parkes Weber syndrome.

Childs Nerv Syst 2021 Jun 15. Epub 2021 Jun 15.

Department of Neurosurgery, Shanghai Ninth People's Hospital, Affiliated to Shanghai JiaoTong University School of Medicine, NO.639 Shanghai Zhizaoju Road, Huangpu District, Shanghai, China.

Background: Parkes Weber syndrome (PWS) is a rare and congenital vascular malformation manifesting as hemihypertrophy of the extremities, cutaneous hemangiomas, varicose veins, and arteriovenous fistula of the affected limbs. The incidence rate of spinal arteriovenous fistula (AVF) associated with PWS is extremely rare.

Case Presentation: We reported a case of an adolescent girl with PWS who presented with a rupture spinal perimedullary AVF at the level of T12-L1. Read More

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[Treatment of locally advanced and metastatic cutaneous squamous cell carcinoma.]

Recenti Prog Med 2021 Jun;112(6):69e-74e

Oncologia Day Hospital, Azienda Ospedaliero-Universitaria di Modena.

Locally advanced and metastatic cutaneous squamous cell carcinoma (cSCC) of the skin is a rare entity and with a poor prognosis. Although less than 5% of patients with squamous carcinoma develop metastases or relapses locally after surgical removal, cSCC is difficult to treat. It tends to develop especially in elderly, frail or patients with important comorbidities and therefore not suitable for receiving aggressive treatments. Read More

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Lymph node and visceral progression without erythroderma or blood worsening in erythrodermic cutaneous T-cell lymphoma: nine cases.

Br J Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Dermatology department, AP-HP, Henri Mondor hospital, Créteil, France.

The prognosis of erythrodermic cutaneous T-cell lymphomas (ECTL) depends upon lymph node (N), visceral (M) involvement, and blood stage (B, i.e circulating Sézary cells, identified upon peripheral blood immunophenotyping, B0: absolute count <250/mm , B1: 250-1000/mm , and B2 stage, Sézary syndrome: ≥1000/mm ) with a 5-year overall survival of 36% for Sézary syndrome, the most common subtype of ECTL. Other prognostic markers include male sex, age >60 years, an elevated rate of lactate dehydrogenase (LDH), and histologic large-cell transformation (LCT). Read More

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Global data analysis supports smoking as the fundamental element associated with geographic gender disparities in hidradenitis suppurativa.

Br J Dermatol 2021 Jun 15. Epub 2021 Jun 15.

Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.

Hidradenitis suppurativa (HS), or acne inversa, is a painful and recurrent inflammatory cutaneous disorder involving the terminal hair follicles of intertriginous and gluteal areas. Epidemiological studies have revealed geographic differences regarding the demographic and clinical characteristics of HS. The gender distribution of HS patients is diverse among different countries. Read More

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Fibroblast-associated protein-α expression and BPV nucleic acid distribution in equine sarcoids.

Vet Pathol 2021 Jun 15:3009858211022696. Epub 2021 Jun 15.

Department of Veterinary Medical Sciences, 9296University of Bologna, Italy.

Sarcoids are the most common cutaneous tumor of equids and are caused by bovine papillomavirus (BPV). Different clinical subtypes of sarcoids are well characterized clinically but not histologically, and it is not known whether viral activity influences the clinical or histological appearance of the tumors. The aim of this study was to verify whether the development of different clinical types of sarcoids or the presence of certain histological features were associated with BPV distribution within the tumor. Read More

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Advanced Wound Diagnostics: Towards Transforming Wound Care into Precision Medicine.

Adv Wound Care (New Rochelle) 2021 Jun 15. Epub 2021 Jun 15.

Tufts University School of Medicine, 12261, Molecular Physiology and Pharmacology, Boston, Massachusetts, United States.

Significance Non-healing wounds are an ever-growing global pandemic with mortality rates and management costs exceeding many common cancers. Although our understanding of the molecular and cellular factors driving wound healing continues to grow, standards for diagnosing and evaluating wounds remain largely subjective and experiential, while therapeutic strategies fail to consistently achieve closure and clinicians are challenged to deliver individualized care protocols. There is a need to apply precision medicine practices to wound care by developing evidence-based approaches, which are predictive, prescriptive, and personalized. Read More

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Covid-19 skin manifestations: an update.

Curr Opin Pediatr 2021 Jun 14. Epub 2021 Jun 14.

Boston Children's Hospital, Dermatology Program Harvard Medical School, Boston, Massachusetts, USA.

Purpose Of Review: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or COVID-19 is a multisystemic disease manifesting mainly with dry cough, fever, and pneumonia and can present with a myriad of cutaneous manifestations. This chapter will review SARS-CoV-2 associated cutaneous findings, including incidence and relevance to the pediatric population.

Recent Findings: The most commonly reported cutaneous findings described for COVID-19 in adults and children were chilblains-like lesions, followed by maculopapular eruption, urticarial lesions, vesicular lesions, and livedoid lesions. Read More

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Leg ulceration due to cutaneous melioidosis in a returning traveller.

BMJ Case Rep 2021 Jun 14;14(6). Epub 2021 Jun 14.

Hospital for Tropical Diseases and Department of Dermatology, University College London Hospitals NHS Foundation Trust, London, UK.

A 26-year-old man, returned to the UK having travelled extensively in Asia. He was referred with a 3-month history of distal leg ulceration following an insect bite while in Thailand. Despite multiple courses of oral antibiotics, he developed two adjacent ulcers. Read More

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Metabolic Alterations and Therapeutic Opportunities in Rare Forms of Melanoma.

Trends Cancer 2021 Jun 11. Epub 2021 Jun 11.

Department of Cancer Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA; Sidney Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA. Electronic address:

Melanoma is derived from melanocytes located in multiple regions of the body. Cutaneous melanoma (CM) represents the major subgroup, but less-common subtypes including uveal melanoma (UM), mucosal melanoma (MM), and acral melanoma (AM) arise that have distinct genetic profiles. Treatments effective for CM are ineffective in UM, AM, and MM, and patient survival remains poor. Read More

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A comparative study on using superior thyroid artery perforator flaps versus traditional sternocleidomastoid myocutaneous flaps for reconstructions after oral cancer ablation: "New tricks for old dogs"?

Oral Oncol 2021 Jun 11:105374. Epub 2021 Jun 11.

Department of Oral Maxillofacial-Head Neck Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, China. Electronic address:

Objectives: To introduce new superior thyroid artery perforator flaps (STAPF), and to compare the clinical outcomes with sternocleidomastoid myocutaneous flaps (SCMMF) for their intraoral applications.

Materials And Methods: Between January 2013 and December 2020, forty-three oral cancer patients who received post-oncologic reconstructions with one of these two regional flaps were retrospectively collected. Their techniques and outcomes were compared. Read More

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[Lesions of the eyebrow].

Rev Med Interne 2021 Jun 11. Epub 2021 Jun 11.

Service de dermato-vénérologie, CHU Ibn Rochd, Casablanca, Maroc.

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A Novel Real-Time PCR Assay for Detection of HLA-A*31:01 in Individuals Being Considered for Carbamazepine Therapy.

CNS Spectr 2021 Apr;26(2):154-155

Genomind, Inc., King of Prussia, PA, USA.

Background: Carbamazepine, an anticonvulsant also used as a mood stabilizer and for trigeminal neuralgia, is associated with serious, sometimes fatal cutaneous adverse drug reactions, including Stevens Johnson Syndrome and toxic epidermal necrolysis1. Current literature demonstrates a genetic predisposition linked to specific class I and II human leukocyte antigen (HLA) types in various ethnic populations2. HLA-A*31:01 is one such HLA type, and is routinely identified by the tag SNP rs1061235. Read More

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Computer-aided clinical image analysis for non-invasive assessment of tumor thickness in cutaneous melanoma.

BMC Res Notes 2021 Jun 14;14(1):232. Epub 2021 Jun 14.

Department of Surgery, Helios University Hospital, Wuppertal, Germany.

Objective: Computerized clinical image analysis is shown to improve diagnostic accuracy for cutaneous melanoma but its effectiveness in preoperative assessment of melanoma thickness has not been studied. The aim of this study, is to explore how melanoma thickness correlates with computer-assisted objectively obtained color and geometric variables. All patients diagnosed with cutaneous melanoma with available clinical images prior to tumor excision were included in the study. Read More

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Clinical characteristics, visceral involvement, and mortality in at-risk or early diffuse systemic sclerosis: a longitudinal analysis of an observational prospective multicenter US cohort.

Arthritis Res Ther 2021 Jun 14;23(1):170. Epub 2021 Jun 14.

Division of Rheumatology and Scleroderma Program, Department of Internal Medicine, University of Michigan, Suite 7C27 300 North Ingalls Street, SPC 5422, Ann Arbor, MI, 48109, USA.

Background: Early diffuse cutaneous systemic sclerosis (dcSSc) has the highest case fatality among rheumatic diseases. We report baseline characteristics, current immunosuppressive therapies, progression of skin and internal organ involvement, and mortality in a multicenter prospective cohort from the United States (US) of America.

Methods: We performed a longitudinal analysis of participants from 12 US centers, from April 2012 to July 2020. Read More

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Agreement among different scales for causality assessment in drug-induced Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis.

Curr Drug Saf 2021 Jun 11. Epub 2021 Jun 11.

Department of Clinical Pharmacology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry-605006, India.

Background And Objective: Identification of the offending drug is crucial and challenging in cases of severe cutaneous adverse drug reactions (CADR) like Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Poor reproducibility and varying levels of agreement have been observed among different causality assessment tools (CATs) in assessing severe CADRs. This study was conducted to examine the agreement among four different CATs in assessing cases of drug-induced SJS, TEN and SJS/TEN overlap. Read More

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Metal-free carbon monoxide-releasing micelles undergo tandem photochemical reactions for cutaneous wound healing.

Chem Sci 2020 Apr 14;11(17):4499-4507. Epub 2020 Apr 14.

CAS Key Laboratory of Soft Matter Chemistry, Hefei National Laboratory for Physical Science at the Microscale, Department of Polymer Science and Engineering, University of Science and Technology of China Hefei 230026 Anhui China

Carbon monoxide (CO) has shown broad biomedical applications. The site-specific delivery and controlled release of CO is of crucial importance to achieve maximum therapeutic benefits. The development of carbon monoxide (CO)-releasing polymers (CORPs) can increase the stability, optimize pharmacokinetic behavior, and reduce the side effects of small molecule precursors. Read More

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Extra-anogenital giant cutaneous squamous cell carcinomas require multidisciplinary management.

Cancer Treat Res Commun 2021 Jun 2;28:100413. Epub 2021 Jun 2.

Dermatology, Antwerp University Hospital, Drie Eikenstraat 655, 2650, Edegem, Belgium.

Cutaneous squamous cell carcinoma (cSCC) is a highly prevalent cancer and the majority of cSCC have a good prognosis. However, a subset of cSCC can progress to advanced disease. We present the first reported case of a giant cSCC located on the breast. Read More

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ALA-PDT successfully treated multiple cSCC in situ and AK in a patient with Epidermodysplasia verruciformis.

Photodiagnosis Photodyn Ther 2021 Jun 11:102395. Epub 2021 Jun 11.

Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China. Electronic address:

5-aminolaevulinic acid photodynamic therapy (ALA-PDT) has emerged as a non-invasive treatment modality for premalignant and malignant skin lesions. It has the advantage of better tolerance and providing better cosmetic outcomes than conventional treatment methods. Herein, we report a patient who suffered from multiple cutaneous squamous cell carcinoma (cSCC) in situ and actinic keratosis (AK) scattered in the body's sun-exposed areas, which had led him to undergo multiple surgical resections since the age of 16. Read More

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Inhibition of desmoglein-1 by aspirin leads to synthetic lethality of keratinocytes in Shuanghuanglian-induced cutaneous eruption response.

Toxicol Lett 2021 Jun 11. Epub 2021 Jun 11.

Chinese Materia Medica College, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China; Tianjin State Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China. Electronic address:

Cutaneous eruptions caused by the combination of aspirin (ASA) and Shuanghuanglian preparations have attracted widespread attention; however, the underlying mechanism remains unclear. This study aimed to evaluate the potential mechanism of cutaneous eruptions caused by a combination of Shuanghuanglian injection powder (SHL) and ASA in vivo and in vitro. ASA and SHL co-administration induced inflammatory responses in HaCat cells, as evidenced by marked increases in the expression of IL-4 and TNF-α, and the level of apoptosis. Read More

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Targeting immunodominant Bet v 1 epitopes with monoclonal antibodies prevents the birch allergic response.

J Allergy Clin Immunol 2021 Jun 11. Epub 2021 Jun 11.

Regeneron Pharmaceuticals, Inc., Tarrytown, NY, USA. Electronic address:

Background: Blocking the major cat allergen, Fel d 1, with monoclonal antibodies (mAbs) was effective in preventing an acute cat-allergic response.

Objective: We sought to extend the allergen-specific antibody approach and demonstrate that a combination of mAbs targeting Bet v 1, the immunodominant and most abundant allergenic protein in birch pollen, can prevent the birch-allergic response.

Methods: Bet v 1-specific mAbs, REGN5713, REGN5714 and REGN5715, were isolated using the VelocImmune platform. Read More

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Parasite species variation and impact of spatial displacement of the population on cutaneous leishmaniasis in Rio de Janeiro, Brazil.

Trans R Soc Trop Med Hyg 2021 Jun 14. Epub 2021 Jun 14.

Departamento de Epidemiologia e Métodos Quantitativos em Saúde, Escola Nacional de Saúde Pública Sérgio Arouca, Fundação Oswaldo Cruz, Rua Leopoldo Bulhões, 1480, Manguinhos, Rio de Janeiro, CEP: 21041-210, RJ, Brazil.

Background: Cutaneous leishmaniasis results from complex interactions between human beings, vectors and the environment. Parasitic species differ in epidemiological and geographical contexts.

Methods: We studied a retrospective cohort of 696 patients with cutaneous leishmaniasis treated at a reference centre in the state of Rio de Janeiro, Brazil, between 2000 and 2015. Read More

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Clinical variants of mycosis fungoides in a cohort.

Gac Med Mex 2021 ;157(1):41-46

Centro Dermatológico "Dr. Ladislao de la Pascua", Mexico City, Mexico.

Introduction: Mycosis fungoides (MF) is the most common primary skin T-cell lymphoma, which is characterized for a heterogeneous clinical expressivity.

Objective: To report clinical variants and sociodemographic characteristics in patients with MF under the care of a dermatological hospital.

Methods: 290 patients with MF clinical and histopathological diagnosis attended to over the course of 11 years were included. Read More

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January 2021

Merkel cell carcinoma of the gluteal region: A rare case report and literature review.

J Pak Med Assoc 2021 Apr;71(4):1273-1276

Department of Medical Oncology, Adiyaman Training and Research Hospital, Adiyaman, Turkey.

Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine cancer that shows aggressive biological behaviour. Although it usually occurs on sun-exposed areas, it can sometimes be seen on non-sun-exposed sites. Here, we present the case of a 66-year-old woman with MCC arising from the right gluteal region that was treated with excision and adjuvant chemoradiotherapy. Read More

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Myiasis in Neglected Cutaneous Squamous Cell Carcinoma of the Head and Neck: Review of Management and Current Protocol Recommendations.

Adv Skin Wound Care 2021 Jul;34(7):372-378

Golda Grinblat, MD, is Senior Consultant, Otolaryngology and Head and Neck Surgery Department, Hillel Yaffe Medical Center, Hadera, Israel. Yulia Frenkel, MD, is Resident, Anesthesiology Department, Sheba Medical Center, Tel Aviv. Itzhak Shochat, MD, is Resident, Otolaryngology and Head and Neck Surgery Department, Hillel Yaffe Medical Center. Andro Košec, MD, PhD, FEBORL-HNS, is Consultant Surgeon, Department of Otorhinolaryngology and Head and Neck Surgery, University Hospital Center Sestre Milosrdnice, School of Medicine, University of Zagreb, Croatia. Ayelet Midbari, MD, is Unit Chief, Pain Relief Unit, Hillel Yaffe Medical Center. Roman Rysin, MD, is Pre-Resident, Plastic Surgery Department, Hillel Yaffe Medical Center. Manjunath Dandinarasaiah, MD, is Associate Professor, Karnataka Institute of Medical Sciences, Vidyanagar, Hubli, Karnataka, India. At the Hillel Yaffe Medical Center, Itzhak Braverman, MD, is Director, Otolaryngology and Head and Neck Surgery Department; and Yoram Wolf, MD, is Unit Chief, Plastic Surgery Department. Acknowledgments: The authors thank Mrs Shelly Rado, Registered Nurse of the Pain Unit at Hillel Yaffe Medical Center for her assistance in wound care. The authors have disclosed no financial relationships related to this article. Submitted June 17, 2020; accepted in revised form October 2, 2020.

Objective: To propose a first-aid management protocol for myiasis in neglected cutaneous squamous cell carcinoma (SCC) in the ED based on a recent literature review.

Data Sources: PubMed.

Study Selection: Inclusion criteria were all series and case reports of primary/secondary cutaneous SCC with myiasis of the head and neck, including orbital SCC cases, published after 2005. Read More

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