191,200 results match your criteria Cutaneous Manifestations Following Exposures to Marine Life


A case of anti-BP230 antibody-positive bullous pemphigoid receiving DPP-4 inhibitor.

Immunol Med 2020 Jul 7:1-3. Epub 2020 Jul 7.

Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan.

Bullous pemphigoid (BP) is a cutaneous autoimmune blistering disorder. Recently, it has been reported that dipeptidyl peptidase-4 inhibitors (DPP4i) is associated with the development of BP (DPP4i-BP). Patients with DPP4i-BP have autoantibodies (autoAbs) preferentially targeting full-length BP180, but not the BP180NC16a domain. Read More

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http://dx.doi.org/10.1080/25785826.2020.1787584DOI Listing

Octreotide-related exocrine pancreatic insufficiency (EPI) in congenital hyperinsulinism.

J Pediatr Endocrinol Metab 2020 Jul 7. Epub 2020 Jul 7.

Department of Pediatrics, Universidad Autónoma de Madrid, Madrid, Spain.

Background Congenital hyperinsulinism (CH) is the most frequent cause of persistent hypoglycemia in the newborn. Octreotide, a long-acting somatostatin receptor analog (SSRA), is a second line treatment for diazoxide unresponsive CH patients. Although it has been found to be a safe and effective treatment, long-term benefits and side effects, have not been thoroughly evaluated. Read More

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http://dx.doi.org/10.1515/jpem-2019-0565DOI Listing

Cutaneous lupus erythematosus: The impact of self-amplifying innate and adaptive immune responses and future prospects of targeted therapies.

Exp Dermatol 2020 Jul 7. Epub 2020 Jul 7.

Department of Dermatology and Allergy, University Hospital Bonn, Germany.

Cutaneous lupus erythematosus (CLE) is a heterogeneous autoimmune disease encompassing a broad spectrum of skin conditions including localized plaques or widespread lesions, which may be accompanied by systemic involvement (systemic lupus erythematosus (SLE)). The disease is characterized by necroptotic keratinocytes and a cytotoxic immune cell infiltrate at the dermo-epidermal junction (DEJ), orchestrated by interferon (IFN)-regulated proinflammatory cytokines. Molecular analyses revealed a strong upregulation of innate and adaptive immune pathways in lesional skin including DNA-recognition pathways, chemokine signalling, antigen-presentation as well as B- and T-cell activation, which are believed to interact in a complex self-amplifying network. Read More

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http://dx.doi.org/10.1111/exd.14146DOI Listing

Drug survival of dupilumab compared to cyclosporin in moderate-to-severe atopic dermatitis patients.

Dermatol Ther 2020 Jul 7. Epub 2020 Jul 7.

Section of Dermatology, Department of Medicine, University of Verona, Verona, Italy.

Dupilumab and cyclosporin are recommended treatments for moderate-to-severe atopic dermatitis (AD). The objective of this study was to investigate drug survival of dupilumab in comparison with CsA, reasons of drug discontinuation, and predictive parameters of drug survival in daily practice. Retrospective study including patients with moderate-to-severe AD treated with dupilumab or cyclosporin (CsA) from January 1, 2019 to April 30, 2020. Read More

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http://dx.doi.org/10.1111/dth.13979DOI Listing

When a mimicker wears strange faces: description of an osteogenic melanoma arising within an ovarian teratoma with focus on its late peritoneal relapse.

Eur Rev Med Pharmacol Sci 2020 Jun;24(12):6569-6575

Dipartimento Scienze della Salute della Donna, del Bambino e di Sanità Pubblica, Unità di Gineco-Patologia e Patologia Mammaria, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

Secondary malignancies arising within mature teratomas are a rare event, originating from malignant transformation of the tissues derived from one of the three germ cell layers. Osteogenic melanoma is exceedingly rare histologic variant of malignant melanoma, in which the melanoma is associated to an osteogenic sarcoma component. To the best of our knowledge, first case of osteogenic melanoma arising within mature ovarian teratoma in a 30-year-old woman without evidence of a primary cutaneous or visceral melanoma. Read More

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http://dx.doi.org/10.26355/eurrev_202006_21641DOI Listing

Chronic cutaneous lupus erythematosus induced by 5-fluorouracil.

Authors:
Philip R Cohen

Expert Rev Clin Pharmacol 2020 Jul 7. Epub 2020 Jul 7.

San Diego Family Dermatology , National City, CA.

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http://dx.doi.org/10.1080/17512433.2020.1793669DOI Listing

Interventions for mycosis fungoides.

Cochrane Database Syst Rev 2020 Jul 7;7:CD008946. Epub 2020 Jul 7.

Department of Dermatology, Venereology and Allergology, Johann Wolfgang Goethe-University Hospital, Frankfurt am Main, Germany.

Background: Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma, a malignant, chronic disease initially affecting the skin. Several therapies are available, which may induce clinical remission for a time. This is an update of a Cochrane Review first published in 2012: we wanted to assess new trials, some of which investigated new interventions. Read More

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http://dx.doi.org/10.1002/14651858.CD008946.pub3DOI Listing

Epidemiology of cutaneous sebaceous carcinoma.

Australas J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

South Australian Institute of Ophthalmology, Royal Adelaide Hospital, The University of Adelaide, Adelaide, Australia.

There has been uncertainty about the demographics and anatomical distribution of cutaneous sebaceous carcinoma. This study aims to investigate these uncertainties by analysing data from various countries. Data were obtained from cancer registries of the United States, England, Norway and Taiwan, and incidence rates were calculated with uniform age-adjustment. Read More

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http://dx.doi.org/10.1111/ajd.13387DOI Listing

Cannabinoids in multiple sclerosis: A neurophysiological analysis.

Acta Neurol Scand 2020 Jul 6. Epub 2020 Jul 6.

Neurology Unit, Department of Translational Medicine, University of Piemonte Orientale, Novara, Italy.

Objectives: To investigate the action of cannabinoids on spasticity and pain in secondary progressive multiple sclerosis, by means of neurophysiological indexes.

Material And Methods: We assessed 15 patients with progressive MS (11 females) using clinical scales for spasticity and pain, as well as neurophysiological variables (H/M ratio, cutaneous silent period or CSP). Testing occurred before (T0) and during (T1) a standard treatment with an oral spray containing delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD). Read More

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http://dx.doi.org/10.1111/ane.13313DOI Listing

Preparation and Characterization of Nanostructured Lipid Carriers for Improved Topical Drug Delivery: Evaluation in Cutaneous Leishmaniasis and Vaginal Candidiasis Animal Models.

AAPS PharmSciTech 2020 Jul 6;21(5):185. Epub 2020 Jul 6.

Department of Pharmacy, Quaid-i-Azam University, Islamabad, 45320, Pakistan.

The present study aimed to develop, characterize and evaluate the amphotericin B-loaded nanostructured lipid carriers (AmB-NLCs) for topical treatment of cutaneous leishmaniasis (CL) and vulvovaginal candidiasis (VVC). AmB-NLCs were characterized for particle size, zeta potential, encapsulation efficiency and surface morphology. Prepared NLCs were also characterized for in vitro drug release, ex vivo skin permeation and deposition before evaluating their in vitro and in vivo efficacy. Read More

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http://dx.doi.org/10.1208/s12249-020-01717-wDOI Listing

Clinicopathological study of blue nevi of the gastrointestinal (GI) tract: first case series.

J Clin Pathol 2020 Jul 6. Epub 2020 Jul 6.

Pathology, Johns Hopkins University, Baltimore, Maryland, USA.

Aim: Blue nevus (BN) is a benign melanocytic proliferation that is typically cutaneous. Extracutaneous BN is infrequent and is reported in the mucosa of various organs. Gastrointestinal (GI) tract BN is rare. Read More

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http://dx.doi.org/10.1136/jclinpath-2020-206757DOI Listing

Cutaneous ulcers revealing diphtheria: A re-emerging disease imported from Indian Ocean countries?

Ann Dermatol Venereol 2020 Jul 3. Epub 2020 Jul 3.

Department of dermatology and internal medicine, Felix Guyon university hospital, Saint-Denis, Reunion.

Introduction: Diphtheria due to Corynebacteriumdiphtheriae (C. diphtheriae) has become rare in developed countries. In France only 10 cases of toxigenic diphtheria have been reported since 1989, in all cases causing pharyngitis and all emanating from endemic countries with exception of one contact case. Read More

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http://dx.doi.org/10.1016/j.annder.2020.04.024DOI Listing

Risk Factors and Cancer Screening in Myositis.

Rheum Dis Clin North Am 2020 Aug 7;46(3):565-576. Epub 2020 Jun 7.

Myositis Center, Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, 3601 5th Avenue, Suite 2B, Pittsburgh, PA 15261, USA; UPMC Arthritis and Autoimmunity Center, Falk Medical Building, 3601 Fifth Avenue, Suite 2B, Pittsburgh, PA 15213, USA. Electronic address:

The idiopathic inflammatory myopathies, particularly dermatomyositis, are associated with an increased risk of cancer. Lung, ovarian, breast, colon, prostate, and cervical cancers, and hematologic malignancies, are among the most common associated cancers. Risk stratification for cancer in patients with myositis is based on clinical risk factors/red flags, myositis clinical subtypes, and myositis-specific autoantibodies. Read More

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http://dx.doi.org/10.1016/j.rdc.2020.05.006DOI Listing

Epidemiological trends of head and neck Cancer survivors in Alberta: towards improved understanding of the burden of disease.

J Otolaryngol Head Neck Surg 2020 Jul 6;49(1):46. Epub 2020 Jul 6.

Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada.

Background: With an increase in the incidence of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) and more favourable survival outcomes, there is now a population of head and neck cancer survivors that are different from preceding decades. In addition, their long-term survivorship issues have become increasing research interests. This study was undertaken to determine the changing epidemiological trends of head and neck cancer survivors in Alberta to better anticipate future demands on healthcare services. Read More

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http://dx.doi.org/10.1186/s40463-020-00443-4DOI Listing

A comparative study on clinical and serological characteristics between patients with rhupus and those with systemic lupus erythematosus and rheumatoid arthritis.

Lupus 2020 Jul 6:961203320938456. Epub 2020 Jul 6.

Rheumatology Department, Hospital Clínic, Barcelona, Spain.

Background: The concomitant presence of two autoimmune diseases - systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) - in the same patient is known as rhupus. We evaluated a group of patients with rhupus to clarify further their clinical, serological and immunogenic features in a multi-centre cohort. In addition, the study aimed to explore the utility of the 2019 European League Against Rheumatism/American College of Rheumatology (EULAR/ACR) SLE classification criteria in our group of patients with rhupus. Read More

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http://dx.doi.org/10.1177/0961203320938456DOI Listing

Clinical features, disease activity and outcomes of Malaysian children with paediatric systemic lupus erythematosus: A cohort from a tertiary centre.

Lupus 2020 Jul 6:961203320939185. Epub 2020 Jul 6.

Paediatric Rheumatology Unit, Selayang Hospital, Batu Caves, Malaysia.

Background: Paediatric systemic lupus erythematosus is a rare autoimmune disease with a wide spectrum of clinical presentation in different populations. We present a cohort of paediatric systemic lupus erythematosus in Malaysia where the disease features and outcomes are still largely unknown.

Methods: A retrospective review of all paediatric systemic lupus erythematosus patients with at least 6 months follow-up at Selayang Hospital from 2004 to 2016. Read More

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http://dx.doi.org/10.1177/0961203320939185DOI Listing

Nitric Oxide-Releasing -Nitrosoglutathione-Conjugated Poly(Lactic--Glycolic Acid) Nanoparticles for the Treatment of MRSA-Infected Cutaneous Wounds.

Pharmaceutics 2020 Jul 2;12(7). Epub 2020 Jul 2.

College of Pharmacy, Pusan National University, Busan 46241, Korea.

-nitrosoglutathione (GSNO) has emerged as a potent agent for the treatment of infected cutaneous wounds. However, fabrication of GSNO-containing nanoparticles has been challenging due to its high hydrophilicity and degradability. The present study aimed to fabricate nanoparticles using newly synthesized GSNO-conjugated poly(lactic--glycolic acid) (PLGA) (GSNO-PLGA; GPNPs). Read More

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http://dx.doi.org/10.3390/pharmaceutics12070618DOI Listing

Expression of miR-135b in Psoriatic Skin and Its Association with Disease Improvement.

Cells 2020 Jul 2;9(7). Epub 2020 Jul 2.

Dermatology Department, Instituto de Investigación Sanitaria Hospital Universitario de la Princesa (IISP), 28006 Madrid, Spain.

miRNAs have been associated with psoriasis since just over a decade. However, we are far from a complete understanding of their role during the development of this disease. Our objective was to characterize the cutaneous expression of miRNAs not previously described in psoriasis, the changes induced following the treatment with biologicals and their association with disease improvement. Read More

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http://dx.doi.org/10.3390/cells9071603DOI Listing

Integrated Assessment of Circulating Cell-Free MicroRNA Signatures in Plasma of Patients with Melanoma Brain Metastasis.

Cancers (Basel) 2020 Jun 25;12(6). Epub 2020 Jun 25.

Department of Translational Molecular Medicine, John Wayne Cancer Institute at Providence Saint John's Health Center, Santa Monica, CA 90404, USA.

Primary cutaneous melanoma frequently metastasizes to distant organs including the brain. Identification of cell-free microRNAs (cfmiRs) found in the blood can be used as potential body fluid biomarkers for detecting and monitoring patients with melanoma brain metastasis (MBM). In this pilot study, we initially aimed to identify cfmiRs in the blood of MBM patients. Read More

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http://dx.doi.org/10.3390/cancers12061692DOI Listing

Protective Effects of Dietary Grape on UVB-Mediated Cutaneous Damages and Skin Tumorigenesis in SKH-1 Mice.

Cancers (Basel) 2020 Jul 1;12(7). Epub 2020 Jul 1.

Department of Dermatology, University of Wisconsin, 1300 University Avenue, Madison, WI 53706, USA.

Non-melanoma skin cancers (NMSCs) are the most diagnosed cancers in the US and occur more frequently in males. We previously demonstrated chemoprotective effects of dietary grape powder (GP) against UVB-mediated skin tumorigenesis in female SKH-1 mice. To expand on this, here, we determined the effects of GP in a short-term UVB exposure protocol (0 or 5% GP, followed by UVB every other day for 2 weeks) in male and female SKH-1 mice, as well as explored any sex-related differences in UVB carcinogenesis via male SKH-1 mice (0, 3, or 5% GP; UVB twice weekly for 28 weeks). Read More

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http://dx.doi.org/10.3390/cancers12071751DOI Listing

Case Report of an Injectional Anthrax in France, 2012.

Microorganisms 2020 Jun 30;8(7). Epub 2020 Jun 30.

CNR-LE Charbon (National Reference Laboratory for Anthrax), Institut de Recherche Biomédicale des Armées, 1 Place Général Valérie André, 91220 Brétigny sur Orge, France.

(1) Background: is a spore-forming, Gram-positive bacterium causing anthrax, a zoonosis affecting mainly livestock. When occasionally infecting humans, provokes three different clinical forms: cutaneous, digestive and inhalational anthrax. More recently, an injectional anthrax form has been described in intravenous drug users. Read More

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http://dx.doi.org/10.3390/microorganisms8070985DOI Listing

Putative Roles for Peptidylarginine Deiminases in COVID-19.

Int J Mol Sci 2020 Jun 30;21(13). Epub 2020 Jun 30.

Tissue Architecture and Regeneration Research Group, School of Life Sciences, University of Westminster, London W1W 6UW, UK.

Peptidylarginine deiminases (PADs) are a family of calcium-regulated enzymes that are phylogenetically conserved and cause post-translational deimination/citrullination, contributing to protein moonlighting in health and disease. PADs are implicated in a range of inflammatory and autoimmune conditions, in the regulation of extracellular vesicle (EV) release, and their roles in infection and immunomodulation are known to some extent, including in viral infections. In the current study we describe putative roles for PADs in COVID-19, based on in silico analysis of BioProject transcriptome data (PRJNA615032 BioProject), including lung biopsies from healthy volunteers and SARS-CoV-2-infected patients, as well as SARS-CoV-2-infected, and mock human bronchial epithelial NHBE and adenocarcinoma alveolar basal epithelial A549 cell lines. Read More

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http://dx.doi.org/10.3390/ijms21134662DOI Listing

Tissue Levels of Flurbiprofen in the Rat Plantar Heel after Short-Duration Topical Iontophoresis are Sufficient to Induce Pharmacodynamic Responses to Local Pain Stimuli.

Pharmaceutics 2020 Jun 30;12(7). Epub 2020 Jun 30.

Laboratory for Drug Delivery & Translational Medicine, School of Pharmacy, Nantong University, 19 Qixiu Road, Nantong 226001, Jiangsu Province, China.

The objective of this study was to investigate the topical iontophoresis of flurbiprofen (FBF) as a means to enhance its local bioavailability and thereby provide an improved and targeted treatment of plantar heel pain. Initial in vitro experiments using porcine ear skin investigated iontophoretic transport of FBF under different conditions. Local FBF biodistribution in the rat paw in vivo was compared after topical or oral administration. Read More

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http://dx.doi.org/10.3390/pharmaceutics12070608DOI Listing

Treatment of high risk human papillomavirus infection in low grade cervical squamous intraepithelial lesion with mild local thermotherapy: Three case reports.

Medicine (Baltimore) 2020 Jul;99(27):e21005

Department of Dermatology, The First Hospital of China Medical University and Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Liaoning.

Introduction: Mild local hyperthermia at 44°C has been proven efficacious in the treatment of cutaneous warts induced by human papillomavirus (HPV), while its effect on cervical intraepithelial neoplasia (CIN) caused by high risk type of HPVs has not been reported.

Patient Concerns: Three patients with low grade CIN and positive high risk HPV types (HPV 16, 31, 52, 56, 58) are reported in this study.

Diagnosis: The diagnosis was based on identification of HPV types and abnormal cytological findings. Read More

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http://dx.doi.org/10.1097/MD.0000000000021005DOI Listing

Characterization of circulating myeloma tumor cells by next generation flowcytometry in scleromyxedema patient: a case report.

Medicine (Baltimore) 2020 Jul;99(27):e20726

Hamad Medical Corporation, Hematology and Medical Oncology Department.

Introduction: Scleromyxedema (rare cutaneous mucinosis), is characterized by the formation of lichenoid papules and presence of Serum monoclonal IgG in most cases, or all; after repeated testing.

Patient Concerns: The patient is a 51-year-old male presented with thick, disfiguring elephant-like erythematous skin folds over the forehead, papular shiny eruptions over ears and trunk and waxy erythematous papules over arms and hands without dysphagia or respiratory or neurologic symptoms DIAGNOSIS: : Skin biopsy from right arm was consistent with scleromyxedema. Serum cryoglobulin was reported negative. Read More

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http://dx.doi.org/10.1097/MD.0000000000020726DOI Listing

Human Skin Equivalents Demonstrate Need for Neuro-Immuno-Cutaneous System.

Adv Biosyst 2019 Jan 13;3(1):e1800283. Epub 2018 Dec 13.

Department of Biomedical Engineering, Tufts University, 4 Colby St., Medford, MA, 02155, USA.

A variety of human skin equivalents (HSEs) has been designed for clinical use or for exploratory skin research. In vitro HSE models have been used to target relationships between the skin and nervous or immune systems but have not yet considered the neuro-immuno-cutaneous (NIC) system. In this study, HSEs are described, with and without neural and immune components, to discern these types of effects. Read More

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http://dx.doi.org/10.1002/adbi.201800283DOI Listing
January 2019

Immunocompromised cutaneous district, isotopic and isopathic phenomena - systematic review.

J Cosmet Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Departments of Dermatology, Medical Sciences School, Unicamp, Campinas, State of São Paulo, Brazil.

Although the development of lesions in skin areas that have undergone injury has long been known, understanding of its pathogenesis is limited. Depending on their peculiarities, those events have been described as isomorphic, reverse isomorphic, pseudoisomorphic, isotopic and isopathic phenomena. Ruocco's immunocompromised cutaneous district (ICD) concept was proposed to include all those phenomena. Read More

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http://dx.doi.org/10.1111/jocd.13592DOI Listing

Miltefosine inhibits the membrane remodeling caused by phospholipase action by changing membrane physical properties.

Biochim Biophys Acta Biomembr 2020 Jul 3:183407. Epub 2020 Jul 3.

Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Córdoba, Argentina; Centro de Investigaciones en Química Biológica de Córdoba (CIQUIBIC), CONICET, Haya de la Torre y Medina Allende, Ciudad Universitaria, X5000HUA Córdoba, Argentina. Electronic address:

Miltefosine (hexadecylphosphocholine or HePC) is an alkylphosphocholine approved for the treatment of visceral and cutaneous Leishmaniasis. HePC exerts its effect by interacting with lipid membranes and affecting membrane-dependent processes. The molecular geometry of HePC suggests that the pharmacological function of HePC is to alter membrane curvature. Read More

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http://dx.doi.org/10.1016/j.bbamem.2020.183407DOI Listing

The influence of size and abiotic factors on cutaneous water loss.

Adv Physiol Educ 2020 Sep;44(3):387-393

Department of Biological Sciences, Southern Illinois University Edwardsville, Edwardsville, Illinois.

The greatest physiological threat to terrestrial life is dehydration; however, examining the factors that influence water balance in a teaching setting can be problematic. The proposed exercise examines cutaneous water loss using gelatin frogs. The use of models provides a unique approach to learning about water loss without the need of Institutional Animal Care and Use Committee approval or specialized equipment to measure dehydration from relatively small invertebrates. Read More

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http://dx.doi.org/10.1152/advan.00152.2019DOI Listing
September 2020

Most chilblains observed during the COVID-19 outbreak occur in patients who are negative for COVID-19 on PCR and serology testing.

Br J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Dermatology Department, University Hospital Bordeaux, Bordeaux, France.

Introduction: Acral lesions, mainly chilblains, are the most frequently reported cutaneous lesions associated with COVID-19. In more than 80% of tested patients, nasopharyngeal swabs were negative on RT-PCR for SARS-CoV-2 when performed, and serology was generally not performed.

Materials And Methods: A national survey was launched on March 30, 2020 by the French society of dermatology asking physicians to report cases of skin manifestations in patients with suspected or confirmed COVID-19 by using a standardized questionnaire. Read More

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http://dx.doi.org/10.1111/bjd.19377DOI Listing

COVID-19 related anagen effluvium.

J Dermatolog Treat 2020 Jul 6:1-4. Epub 2020 Jul 6.

Department of Dermatology and Venereology, Baghdad Teaching Hospital, Baghdad, Iraq.

New COVID-19 skin manifestations continue to be described. We present a patient with COVID-19 related anagen effluvium. The patient was treated with and responded to low dose systemic steroids to treat an accompanying extensive COVID-19-related urticaria and maculopapular rash. Read More

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http://dx.doi.org/10.1080/09546634.2020.1792400DOI Listing

Rare case of CD8+ CD56+ cytotoxic variant of mycosis fungoides clinically presenting with a combination of hypopigmentation and poikiloderma.

Int J Dermatol 2020 Jul 6. Epub 2020 Jul 6.

Department of Dermatology, Severance Hospital, Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Korea.

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http://dx.doi.org/10.1111/ijd.15045DOI Listing

Surgical management of recurrent cutaneous squamous cell carcinoma of the head and neck after definitive surgery and radiotherapy.

ANZ J Surg 2020 Jul 5. Epub 2020 Jul 5.

Division of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.

Background: Surgery is the primary treatment for patients with recurrent head and neck cutaneous squamous cell carcinoma (cSCC) who have previously been treated by definitive surgery and radiotherapy. There are limited published data to direct management and the role of immunotherapy is currently under evaluation.

Methods: This was a retrospective study of patients with at least stage III recurrent head and neck cSCC previously managed by definitive surgery and radiotherapy. Read More

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http://dx.doi.org/10.1111/ans.16095DOI Listing

Thermal imaging for microvascular free tissue transfer monitoring: Feasibility study using a low cost, commercially available mobile phone imaging system.

Head Neck 2020 Jul 6. Epub 2020 Jul 6.

Department of Otolaryngology-Head and Neck Surgery, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Background: The use of infrared thermography to evaluate the perfusion of tissue flaps have been studied. This study aims to evaluate the utility of thermal imaging for flap monitoring with a low-cost, readily available smartphone imaging device.

Methods: Adult subjects who underwent head and neck reconstruction using a microvascular free flap with a cutaneous paddle were recruited. Read More

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http://dx.doi.org/10.1002/hed.26350DOI Listing

Neurolymphomatosis, a rare manifestation of peripheral nerve involvement in lymphomas: suggestive features and diagnostic challenges.

J Peripher Nerv Syst 2020 Jul 5. Epub 2020 Jul 5.

Neurology Unit, Department of Neuroscience, University of Padova, Padova, Italy.

Background: Neurolymphomatosis, the infiltration of the peripheral nervous system from lymphoid cells, represents an uncommon manifestation of lymphomas. We describe the challenging diagnostic work-up in a patient with neurolymphomatosis.

Case Report: a 58-yr-old woman with previous breast diffuse large B-cell lymphoma (DLBCL) treated with chemo- and radiation-therapy, presented with dysesthesias, neuropathic pain at left abdomen and thigh, and weakness at left lower limb 9 years after disease remission. Read More

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http://dx.doi.org/10.1111/jns.12401DOI Listing

CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR‑1236‑3p in cutaneous squamous cell carcinoma.

Int J Oncol 2020 Aug 14;57(2):478-487. Epub 2020 May 14.

Department of Burn and Plastic Surgery, The Affiliated Huaian No. 1 People's Hospital of Nanjing Medical University, Huaian, Jiangsu 223300, P.R. China.

Circular ribonucleic acids (circRNAs) serve a vital role in the pathological processes of a number of diseases. Previous microarray results of circRNA expression revealed that hsa_circ_0070933 and hsa_circ_0070934, two circRNAs associated with the La ribonucleoprotein 1B gene, were highly expressed in cutaneous squamous cell carcinoma (CSCC). The present study aimed to explore the specific role of these circRNAs in CSCC. Read More

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http://dx.doi.org/10.3892/ijo.2020.5066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7307596PMC

Prognostic significance of serum lactate dehydrogenase in patients undergoing radical cystectomy for bladder cancer.

Urol Oncol 2020 Jul 2. Epub 2020 Jul 2.

Department of Urology, The No.1 Hospital of Shijiazhuang/Shijiazhuang People's Hospital, Shijiazhuang, China.

Background: To investigate the prognostic significance of preoperative serum lactate dehydrogenase (LDH) in patients undergoing radical cystectomy for bladder cancer (BCa).

Patients And Methods: A cohort of 263 patients undergoing open or laparoscopic radical cystectomy between 2011 and 2016 was studied. Baseline characteristics, hematological variables, follow-up data were collected. Read More

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http://dx.doi.org/10.1016/j.urolonc.2020.05.031DOI Listing

Topical aloe vera for the treatment of cetuximab-related acneiform rash in colorectal cancer: A case report.

J Oncol Pharm Pract 2020 Jul 5:1078155220937751. Epub 2020 Jul 5.

Faculty of Medicine, Department of Medical Oncology, Ankara University, Ankara, Turkey.

Introduction: Colorectal cancer is one of the most common cancers in the world. Cetuximab is an epidermal growth factor receptor (EGFR) inhibitor which provides survival benefit when combined with chemotherapy in RAS wild type metastatic colorectal cancer. Cutaneous toxicities associated with cetuximab have a significant impact on patient quality of life, treatment continuation and healthcare resource utilization. Read More

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http://dx.doi.org/10.1177/1078155220937751DOI Listing

Immunotherapy in sinonasal melanoma: treatment patterns and outcomes compared to cutaneous melanoma.

Int Forum Allergy Rhinol 2020 Jul 5. Epub 2020 Jul 5.

Department of Surgery, Division of Otolaryngology-Head and Neck Surgery, University of California San Diego Health, La Jolla, CA.

Background: Although treatment with checkpoint blockade is now accepted as standard of care for cutaneous melanoma, few studies have investigated its role in sinonasal melanoma (SNM). We aimed to evaluate whether immunotherapy was associated with improved survival in SNM and to compare the effect of immunotherapy in metastatic sinonasal and cutaneous melanoma.

Methods: This was a cohort study of patients included in the United States National Cancer Database who had been diagnosed with sinonasal or cutaneous melanoma between 2012 and 2015 and had complete information regarding immunotherapy status. Read More

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http://dx.doi.org/10.1002/alr.22628DOI Listing

Establishment of a Mouse Model for Post-Inflammatory Hyperpigmentation.

Pigment Cell Melanoma Res 2020 Jul 4. Epub 2020 Jul 4.

Department of Dermatology, Yamagata University, Faculty of Medicine, Yamagata, Japan.

Post-inflammatory hyperpigmentation (PIH) is a common cutaneous condition that can cause a disfigured appearance. However, the pathophysiology of PIH remains poorly understood, at least in part, because an appropriate animal model for research has not been established. In order to analyze the pathomechanism of PIH, we successfully induced PIH in a hairless version of transgenic mice (hk14-SCF Tg/HRM) that have a human-type epidermis containing melanin by repeated hapten application of 2,4-dinitrofluorobenzene. Read More

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http://dx.doi.org/10.1111/pcmr.12911DOI Listing

A case of primary cutaneous B-cell lymphoma with immature features in an old man. Diffuse Large B-cell Lymhpoma with immature features or B-cell Lymhpoblastic Lymphoma?

J Cutan Pathol 2020 Jul 4. Epub 2020 Jul 4.

Oncology and Hematology Unit, Department of Precision Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Primary cutaneous B-cell lymphomas are a heterogeneous group of lymphoid neoplasms primarily occurring in the skin. Although most cases are represented by primary cutaneous follicle center cell lymphoma, primary cutaneous marginal zone lymphoma and leg-type diffuse large B-cell lymphoma, other diffuse large B-cell lymphomas and B-cell lymphoblastic lymphoma may rarely present primarily in the skin. In this setting, the presence of histopathologic and immunohistochemical features of cellular immaturity is exceedingly rare and may represent a diagnostic challenge. Read More

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http://dx.doi.org/10.1111/cup.13795DOI Listing

Safe, Mild Ultraviolet-B Exposure: An Essential Human Requirement for Vitamin D and Other Vital Bodily Parameter Adequacy: A Review.

Authors:
J L M Hawk

Photodermatol Photoimmunol Photomed 2020 Jul 5. Epub 2020 Jul 5.

Emeritus Professor of Dermatological Photobiology and Former Head, Photobiology Department, St John's Institute of Dermatology, King's College London, UK.

The enigma of skin sunburning, skin ageing and skin cancer and essential vitamin D production both resulting from solar ultraviolet-B (280-315 nanometres, nm) (UVB) exposure has long puzzled photobiologists. Advice to patients by non-photobiological clinicians is now often to sunbathe to acquire vitamin D adequacy. However, modern work shows only mild UVB exposure is needed to maintain satisfactory levels, which have been demonstrated as very similar in summer and winter from about 25° to 70° north. Read More

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http://dx.doi.org/10.1111/phpp.12584DOI Listing

A rare case of lupoid leishmaniasis defying diagnosis for a decade.

J Cutan Pathol 2020 Jul 4. Epub 2020 Jul 4.

Yale University School of Medicine Department of Dermatology.

Cutaneous leishmaniasis is a common disease affecting millions in endemic areas worldwide. We present a case of lupoid leishmaniasis, a rare variant of cutaneous leishmaniasis, which clinically mimicked sarcoidosis and/or granulomatous rosacea for ten years until ultimate diagnosis. An 82-year-old U. Read More

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http://dx.doi.org/10.1111/cup.13793DOI Listing

Malignant Leakage After Sleeve Gastrectomy: Endoscopic and Surgical Approach.

Obes Surg 2020 Jul 4. Epub 2020 Jul 4.

General Endocrine Surgery Department, Lille University Hospital CHU Lille, Lille, France.

Purpose: Gastric leak occurs after sleeve gastrectomy (SG) in 2% of cases. Most staple-line disruptions (SLD) can be successfully treated with first-line endoscopic procedures. Less favorable situations may lead to more complex therapeutic strategies, like conversion to Roux-en-Y gastric bypass (RYGBP). Read More

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http://dx.doi.org/10.1007/s11695-020-04818-4DOI Listing

Cutaneous lupus erythematosus and cardiovascular disease: current knowledge and insights into pathogenesis.

Clin Rheumatol 2020 Jul 5. Epub 2020 Jul 5.

Harvard Medical School, Boston, MA, USA.

Multiple autoinflammatory diseases, including psoriasis, psoriatic arthritis, and systemic lupus erythematosus, have been linked to increased risk of cardiovascular disease. Inflammation is known to play a key role in the pathogenesis of atherosclerosis, thus the contribution of systemic immune dysregulation, which characterizes such inflammatory conditions, towards the development of cardiovascular disease has garnered considerable interest. Cutaneous lupus erythematosus (CLE) is a chronic inflammatory skin disease, but risk of cardiovascular disease amongst patients with cutaneous lupus is less well known. Read More

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http://dx.doi.org/10.1007/s10067-020-05257-3DOI Listing

The MelFo Study UK: Effects of a Reduced-Frequency, Stage-Adjusted Follow-Up Schedule for Cutaneous Melanoma 1B to 2C Patients After 3-Years.

Ann Surg Oncol 2020 Jul 4. Epub 2020 Jul 4.

Department of Surgical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Background: Evidence-based guidelines for follow-up treatment of American Joint Committee on Cancer (AJCC) stages 1B to 2C melanoma patients are lacking. The MELanoma FOllow-up study is an international phase 3 randomized trial, and the 3-year interim data were recently reported from the Netherlands. The study was undertaken concurrently with a British cohort for comparison and validation of the Dutch study. Read More

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http://dx.doi.org/10.1245/s10434-020-08758-2DOI Listing

Camrelizumab in advanced or metastatic solid tumour patients with DNA mismatch repair deficient or microsatellite instability high: an open-label prospective pivotal trial.

J Cancer Res Clin Oncol 2020 Jul 4. Epub 2020 Jul 4.

Shanghai East Hospital, Tongji University School of Medicine, No. 150 Ji-Mo Rd., Shanghai, 200120, China.

Purpose: Patients with DNA mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) cancers are prone to response to programmed cell death-1 (PD-1) checkpoint inhibitors. Therefore, we explored the efficacy and safety of a PD-1 checkpoint inhibitor camrelizumab in advanced or metastatic solid tumour with dMMR/MSI-H.

Methods: Patients with dMMR/MSI-H advanced or metastatic solid tumours who had received at least one line of prior systemic chemotherapy were recruited. Read More

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http://dx.doi.org/10.1007/s00432-020-03251-5DOI Listing

Ante-natal counseling in phacomatoses.

Childs Nerv Syst 2020 Jul 5. Epub 2020 Jul 5.

Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Objectives: Phacomatoses are a group of neuro-oculo-cutaneous syndromes/ neurocutaneous disorders, involving structures arising from the embryonic ectoderm. Most of phacomatoses including the most common ones:, neurofibromatosis type I and type II (NF1, NF2) and tuberosclerosis complex (TSC), are autosomal dominant genetic disorders with full penetrance and variable expression. As no effective treatment exists, the only way to prevent the disease, is by prenatal genetic diagnosis (either chorionic villus sampling-CVS or amniocentesis-AC) and termination of pregnancy or performing preimplantation genetic testing (PGT). Read More

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http://dx.doi.org/10.1007/s00381-020-04776-3DOI Listing

Chloroquine for prolonged skin analgesia in rats.

Neurosci Lett 2020 Jul 2:135233. Epub 2020 Jul 2.

Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan; Department of Physical Therapy, College of Health Care, China Medical University, Taichung, Taiwan. Electronic address:

The purpose of this study was to investigate the ability of chloroquine and chloroquine in combination with vasoconstrictor epinephrine to act as a local anesthetic in skin analgesia. After subcutaneous injection of drugs in rats, the inhibition of the cutaneous trunci muscle reflex (CTMR) is designed for evaluation of the cutaneous analgesic effect. The analgesic effect of chloroquine was compared with that of bupivacaine or coadministration of chloroquine and epinephrine. Read More

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http://dx.doi.org/10.1016/j.neulet.2020.135233DOI Listing

The spectrum of COVID-19-associated dermatologic manifestations: an international registry of 716 patients from 31 countries.

J Am Acad Dermatol 2020 Jul 2. Epub 2020 Jul 2.

Department of Dermatology, University of California San Francisco, San Francisco, CA.

Background: Coronavirus disease 2019 (COVID-19) has associated cutaneous manifestations.

Objective: To characterize the diversity of cutaneous manifestations of COVID-19, and facilitate understanding of underlying pathophysiology.

Methods: Case series from an international registry from the American Academy of Dermatology and International League of Dermatological Societies. Read More

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http://dx.doi.org/10.1016/j.jaad.2020.06.1016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7331510PMC