179,391 results match your criteria Cutaneous Manifestations Following Exposures to Marine Life


Lipid gene nanocarriers for the treatment of skin diseases: current state-of-the-art.

Eur J Pharm Biopharm 2019 Feb 19. Epub 2019 Feb 19.

Laboratory of Pharmaceutical Technology and Biopharmacy, CIRM, University of Liege, Belgium.

Nucleic acids carried by non-viral nanovectors have demonstrated high potential as a therapeutic strategy for gene-related diseases. The dermal or transdermal gene delivery allow to target local skin diseases or to reach the blood stream. However, the skin is the first defense barrier of the body and must be overcome to distribute nucleic acids. Read More

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http://dx.doi.org/10.1016/j.ejpb.2019.02.012DOI Listing
February 2019

Development of novel biocompatible thermosensitive anti-adhesive agents using human-derived acellular dermal matrix.

PLoS One 2019 22;14(2):e0212583. Epub 2019 Feb 22.

Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.

Postoperative adhesion is a natural phenomenon that occurs in damaged tissue cells. Several anti-adhesion agents are currently used, but there is no leading-edge product with excellent adhesion-preventive effects. The purpose of this study was to develop ideal anti-adhesive agents using human-derived acellular dermal matrix (ADM). Read More

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212583PLOS
February 2019

A Review of the Dermatologic Symptoms of Idiopathic Mast Cell Activation Syndrome

J Drugs Dermatol 2019 Feb;18(2):162-168

Since the first reported cases in 2007, idiopathic mast cell activation syndrome has been increasingly recognized. Understanding of the cutaneous manifestations of this condition is imperative for dermatologists given the substantial clinical heterogeneity in its presentation and high estimated prevalence. A review of PubMed® and SCOPUS® databases was performed in order to investigate the most common dermatologic manifestations of idiopathic mast cell activation syndrome. Read More

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February 2019

Metastasis of cutaneous squamous cell carcinoma in organ transplant recipients and the immunocompetent population: is there a difference? a systematic review and meta-analysis.

J Eur Acad Dermatol Venereol 2019 Feb 22. Epub 2019 Feb 22.

Department of dermatology, Leiden University Medical Centre, Leiden, the Netherlands.

Background: Organ transplant recipients (OTR) have a higher risk of developing cutaneous squamous cell carcinoma (cSCC) compared to the immunocompetent population. Immunosuppression is often stated as a risk factor for metastasis. However, evidence for this is scarce. Read More

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http://dx.doi.org/10.1111/jdv.15396DOI Listing
February 2019

Extensive cutaneous necrosis in monoclonal cryoglobulinemia: an example of monoclonal gammopathy of cutaneous significance.

Authors:
D Lipsker

J Eur Acad Dermatol Venereol 2019 Feb 22. Epub 2019 Feb 22.

Faculté de Médecine, Université de Strasbourg et Clinique Dermatologique, Hôpitaux Universitaires, Strasbourg, France.

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http://dx.doi.org/10.1111/jdv.15397DOI Listing
February 2019

Linear porokeratosis associated with Bardet-Biedl syndrome: A case report.

Pediatr Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Dermatology, University of Virginia Health System, Charlottesville, Virginia.

This case report presents a 17-year-old boy with Bardet-Biedl syndrome (BBS) and a long-standing hyperpigmented eruption on the left trunk and upper extremity, clinically and histologically consistent with linear porokeratosis (LP). BBS patients frequently require solid organ transplant, and subsequent immunosuppression places them at especially high risk for malignant transformation of premalignant skin lesions such as LP. Although BBS affects multiple organ systems, there are only a handful of case reports detailing associated cutaneous involvement, and, to our knowledge, this is the first reported case of linear porokeratosis occurring in patient with BBS. Read More

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http://dx.doi.org/10.1111/pde.13776DOI Listing
February 2019

spp. Infection Rate and Feeding Patterns of Sand Flies (Diptera: Psychodidae) from a Hyperendemic Cutaneous Leishmaniasis Community in Panamá.

Am J Trop Med Hyg 2019 Feb 18. Epub 2019 Feb 18.

Programa Centroamericano de Maestría en Entomología, Universidad de Panamá, Ciudad de Panamá, Panamá.

American cutaneous leishmaniasis (ACL) is a common and important vector-borne parasitic zoonosis in Panamá. Here, we study spp. infection rates and blood-feeding patterns among common sand flies in Trinidad de Las Minas, a rural community with hyperendemic ACL transmission, and where a deltamethrin fogging trial was performed. Read More

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http://dx.doi.org/10.4269/ajtmh.17-0628DOI Listing
February 2019

Patients' Global Impression of Change (PGIC) in the Management of Peripheral Neuropathic Pain: Clinical Relevance and Correlations in Daily Practice.

Eur J Pain 2019 Feb 21. Epub 2019 Feb 21.

Département d'Evaluation et Traitement de la Douleur, Centre Hospitalier Universitaire (CHU) de Nice, Fédération Hospitalo-Universitaire InovPain, Université Côte d'Azur, France.

Background: Patient-Reported Outcome (PRO) instruments have been developed to evaluate pain management in daily practice; the PGIC is particularly recommended by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT). The prospective non-interventional multicenter PRO-QURE study aimed at assessing correlations between PGIC and pain measurements and treatment effects in patients followed in French pain centers.

Methods: Respectively, 495 and 379 patients with peripheral neuropathic pain initiating treatment with capsaicin 8% cutaneous patch(es) (female, 62. Read More

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http://dx.doi.org/10.1002/ejp.1378DOI Listing
February 2019

Companion hamsters with dermatological lesions; a retrospective study of 102 cases at two university veterinary teaching hospitals (1985-2018).

Vet Dermatol 2019 Feb 22. Epub 2019 Feb 22.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 944 Garrod Dr, Davis, CA, 95616, USA.

Background: Hamsters are popular companion animals which may present to veterinarians for treatment of skin diseases. Most descriptions of dermatoses in hamsters have primarily been in case reports and in text books.

Hypothesis/objectives: To document skin diseases and their prevalence in companion hamsters examined in northern California, USA, and Nantes, France, and to investigate predilections for the most common conditions documented in medical records over a 33 year or 15 year period, respectively. Read More

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http://dx.doi.org/10.1111/vde.12730DOI Listing
February 2019

Time to recurrence after surgical excision of atypical fibroxanthoma-updated systematic review and meta-analysis.

Australas J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Medicine, Monash University, Melbourne, Victoria, Australia.

Atypical fibroxanthoma (AFX) remains a rare cutaneous dermally based fibrohistiocytic tumour with high rates of local recurrence. Mohs micrographic surgery (MMS) and wide local excision (WLE) with margins 1-2 cm are two surgical options. It is unclear whether timing of recurrence following surgical excision of AFX differs according to technique. Read More

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http://dx.doi.org/10.1111/ajd.13010DOI Listing
February 2019

CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma-Leg Type.

Case Rep Dermatol Med 2019 16;2019:3730915. Epub 2019 Jan 16.

Department of Anatomy-Histology-Embryology, Faculty of Medicine, School of Health Sciences, University of Ioannina, Ioannina, Greece.

Most primary cutaneous B-cell lymphomas (PCBCL) are CD5 negative, and only a few cases were found to express CD5. We report the first well-documented CD5+ primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT). A 71-year-old woman with a history of Multiple Sclerosis was admitted because of a nodule at the left thigh. Read More

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http://dx.doi.org/10.1155/2019/3730915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6354159PMC
January 2019

Neurocutaneous Melanosis in Association With Large Congenital Melanocytic Nevi in Children: A Report of 2 Cases With Clinical, Radiological, and Pathogenetic Evaluation.

Front Neurol 2019 7;10:79. Epub 2019 Feb 7.

Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan.

Melanocytic nevi present at birth, or within the first few months of life, are defined as congenital melanocytic nevi (CMN). Neurocutaneous melanosis (NCM) is a rare disorder, represents pigment cell tumors of the leptomeninges, and occurs in association with large or multiple CMN. NCM carries an extremely poor prognosis. Read More

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http://dx.doi.org/10.3389/fneur.2019.00079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6374324PMC
February 2019

Possible treatment for cutaneous lichen planus: An in vitro anti-inflammatory role of Angelica polysaccharide in human keratinocytes HaCaT.

Int J Immunopathol Pharmacol 2019 Jan-Dec;33:2058738418821837

Department of Dermatology, The Affiliated Hospital of Qingdao University, Qingdao, China.

Cutaneous lichen planus (CLP) is an autoimmune disease. Angelica polysaccharide (AP) has been found to exert immunomodulation activity. In this study, we explored the roles of AP in lipopolysaccharide (LPS)-induced inflammatory injury of human keratinocytes (HaCaT cells), as well as the underlying mechanisms. Read More

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http://dx.doi.org/10.1177/2058738418821837DOI Listing
February 2019

Proposal for Treatment of Severe Dupuytren Disease in 2 Steps: Progressive Distraction With External Fixator and Collagenase - A Preliminary Case Series.

Hand (N Y) 2019 Feb 22:1558944718822086. Epub 2019 Feb 22.

1 University Hospital of Verona, Italy.

Background: We want to describe a treatment for advanced Dupuytren disease using a spanning external fixator (EF) applied dorsally to produce progressive extension, followed by collagenase injection.

Methods: Between October 2014 and September 2016, a total of 22 fingers from 18 patients were treated with an EF. The devices were implanted under local anesthesia, and the patients were instructed to gradually extend the hinge to gain a progressive extension. Read More

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http://dx.doi.org/10.1177/1558944718822086DOI Listing
February 2019

Phytochemicals of Cinnamomi Cortex: Cinnamic Acid, but not Cinnamaldehyde, Attenuates Oxaliplatin-Induced Cold and Mechanical Hypersensitivity in Rats.

Nutrients 2019 Feb 19;11(2). Epub 2019 Feb 19.

Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Korea.

A chemotherapy drug, oxaliplatin, induces cold and mechanical hypersensitivity, but effective treatments for this neuropathic pain without side effects are still lacking. We previously showed that Cinnamomi Cortex suppresses oxaliplatin-induced pain behaviors in rats. However, it remains unknown which phytochemical of Cinnamomi Cortex plays a key role in that analgesic action. Read More

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http://dx.doi.org/10.3390/nu11020432DOI Listing
February 2019

Activated Protein C in Cutaneous Wound Healing: From Bench to Bedside.

Int J Mol Sci 2019 Feb 19;20(4). Epub 2019 Feb 19.

Sutton Arthritis Research Laboratory, Kolling Institute of Medical Research, Sydney Medical School, Northern Clinical School, University of Sydney, Sydney, NSW 2065, Australia.

Independent of its well-known anticoagulation effects, activated protein C (APC) exhibits pleiotropic cytoprotective properties. These include anti-inflammatory actions, anti-apoptosis, and endothelial and epithelial barrier stabilisation. Such beneficial effects have made APC an attractive target of research in a plethora of physiological and pathophysiological processes. Read More

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http://dx.doi.org/10.3390/ijms20040903DOI Listing
February 2019

Adipose tissue -derived mesenchymal stem cells and keratinocytes co-culture on Gelatin/Chitosan/β- Glycerol Phosphate Nanoscaffold in skin regeneration.

Cell Biol Int 2019 Feb 21. Epub 2019 Feb 21.

Stem Cell and Regenerative Medicine Research Group, Academic Center for Education, Culture and Research(ACECR), Razavi Khorasan Branch, Mashhad, Iran.

Using cell-based engineered skin is an emerging strategy for treating difficult-to-heal wounds To date, much endeavor has been devoted to the -fabrication of appropriate scaffolds with suitable biomechanical properties to support cell viability and growth in the microenvironment of a wound. The aim of this research was to assess the impact of adipose tissue-derived mesenchymal stem cells (AD-MSCs) and keratinocytes on Gelatin/Chitosan/β-Glycerol Phosphate (GCGP) nanoscaffold in full-thickness excisional skin wound healing of rats. . Read More

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http://dx.doi.org/10.1002/cbin.11119DOI Listing
February 2019

Folliculotropic mycosis fungoides in a pediatric patient mimicking black dot tinea capitis.

Pediatr Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Section of Pediatric Dermatology, Departments of Dermatology and Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin.

Immunosuppression following organ transplantation is a known risk factor for the development of lymphoproliferative disorders. Mycosis fungoides, a rare entity in pediatric patients, has seldom been reported as a post-transplant lymphoproliferative disorder. We report a case of folliculotropic mycosis fungoides in a pediatric patient following liver transplantation that was initially diagnosed as tinea capitis. Read More

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http://dx.doi.org/10.1111/pde.13768DOI Listing
February 2019

Chemoradiotherapy could improve overall survival of patients with stage IV cutaneous squamous cell carcinoma: analysis of 34 cases.

Br J Dermatol 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, University of Tsukuba, Tsukuba, Japan.

Cutaneous squamous cell carcinoma (cSCC) is the second most common non-melanoma skin cancer, comprising approximately 20% of all skin malignancies . The prognoses of patients with unresectable disease, such as locally advanced tumour or distant metastases, are known to be relatively poor due to lack of effective standardized systemic therapies . When surgery is not feasible, non-surgical approaches such as chemotherapy, radiation therapy (RT), and chemoradiotherapy (CRT; chemotherapy with radiation), are considered as alternative treatments . Read More

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http://dx.doi.org/10.1111/bjd.17792DOI Listing
February 2019

Obesity Decreases Hepatic 25-Hydroxylase Activity Causing Low Serum 25-Hydroxyvitamin D.

J Bone Miner Res 2019 Feb 21:e3686. Epub 2019 Feb 21.

Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia and the Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Normal vitamin D homeostasis is critical for optimal health; nevertheless, vitamin D deficiency is a worldwide public health problem. Vitamin D insufficiency is most commonly due to inadequate cutaneous synthesis of cholecalciferol and/or insufficient intake of vitamin D, but can also arise as a consequence of pathological states such as obesity. Serum concentrations of 25(OH)D (calcidiol) are low in obesity, and fail to increase appropriately after vitamin D supplementation. Read More

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http://dx.doi.org/10.1002/jbmr.3686DOI Listing
February 2019

Resolution of acenocoumarol-associated calciphylaxis with drug withdrawal.

Australas J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Clinical Hospital and University and School of Medicine of Santiago de Compostela, Santiago de Compostela, Spain.

Calciphylaxis is a syndrome of cutaneous ischaemic necrosis and ulceration due to arteriolar calcification with subsequent thrombosis, which rarely presents in patients without terminal kidney disease. Recently, several reports of coumarins-associated calciphylaxis have stressed the relevance of anticoagulant therapy as an important risk factor for the development of this condition. We report five cases of acenocoumarol-associated, biopsy-proven calciphylaxis in women aged between 64 and 92 years. Read More

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http://dx.doi.org/10.1111/ajd.13006DOI Listing
February 2019

Cutaneous findings in Bardet-Biedl syndrome.

Int J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Marshfield Medical Center, Marshfield, WI, USA.

Background: Bardet-Biedl syndrome (BBS) is a rare, pleiotropic syndrome and member of a diverse group of disorders known as ciliopathies. Improved understanding of dermatoses in BBS will further understanding of the syndrome and will help define the role of dermatologists in providing care for patients with BBS. The purpose of this study was to describe the cutaneous phenotype of BBS in patients attending a large, multispecialty BBS clinic. Read More

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http://dx.doi.org/10.1111/ijd.14412DOI Listing
February 2019

Successful Treatment of Generalized Eruptive Keratoacanthoma of Grzybowski with Acitretin.

Dermatol Ther (Heidelb) 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, Saint-Louis Hospital, AP-HP, INSERM U976, University of Paris 7 Paris Diderot, Paris, France.

Introduction: Keratoacanthomas (KA) are common cutaneous skin tumors originating from the hair follicles. Unlike squamous cell carcinoma, KA can regress spontaneously and have a benign evolution. Solitary KA is the most common form but familial multiple KA (Ferguson-Smith type), genetically predisposed KA (such as in xeroderma pigmentosum, or Muir-Torre syndrome), or sporadic multiple eruptive KA (Grzybowski type) have been described. Read More

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http://dx.doi.org/10.1007/s13555-019-0287-0DOI Listing
February 2019

Intralesional Methotrexate for the Treatment of Keratoacanthoma: The Neapolitan Experience.

Dermatol Ther (Heidelb) 2019 Feb 21. Epub 2019 Feb 21.

Department of Dermatology, University of Naples Federico II, Naples, Italy.

Introduction: Keratoacanthomas are cutaneous neoplasms known for their rapid growth and spontaneous regression over a long time period. Their treatment can be difficult because of the potentially large field size and number of lesions. Intralesional methotrexate constitutes an effective, nonsurgical treatment of keratoacanthomas, as proven by our experience. Read More

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http://dx.doi.org/10.1007/s13555-019-0286-1DOI Listing
February 2019

Multiple Cutaneous Nodules and Limb Swelling.

JAMA Oncol 2019 Feb 21. Epub 2019 Feb 21.

Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1001/jamaoncol.2018.6982DOI Listing
February 2019

Cutaneous Carcinosarcoma of the Medial Canthus Discovered on Mohs Debulk Analysis.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, UT Southwestern Medical Center, Dallas, Texas.

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http://dx.doi.org/10.1097/DSS.0000000000001840DOI Listing
February 2019

Erythematous Papules After Microneedle Therapy for Facial Rejuvenation.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Miami, Florida.

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http://dx.doi.org/10.1097/DSS.0000000000001727DOI Listing
February 2019

A Retrospective Cohort Study of Cutaneous Squamous Cell Carcinoma With Lymph Node Metastasis: Risk Factors and Clinical Course.

Dermatol Surg 2019 Feb 13. Epub 2019 Feb 13.

Department of Dermatology, Keck Medicine of the University of Southern California, Los Angeles, California.

Background: The single most important prognostic indicator for mortality in patients with cutaneous squamous cell carcinoma (SCC) is the development of nodal metastasis (NM).

Objective: To characterize the risk factors for and clinical course of cutaneous SCC with NM.

Methods: Ten-year retrospective cohort study (2006-2017) at an academic tertiary care center reviewing 53 cutaneous SCC tumors with NM. Read More

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http://dx.doi.org/10.1097/DSS.0000000000001828DOI Listing
February 2019

A population-based study of the treatment effect of first-line ipilimumab for metastatic or unresectable melanoma.

Melanoma Res 2019 Feb 14. Epub 2019 Feb 14.

Division of Cancer Care and Epidemiology, Cancer Research Institute.

Ipilimumab is an anti-CTLA4 monoclonal antibody with demonstrated efficacy for metastatic melanoma in randomized controlled trials, including in the first-line setting. Population-based outcomes directly compared with historic chemotherapy treatment in metastatic or unresectable melanoma are lacking. Using population-based data from the province of Ontario, the benefit of first-line ipilimumab was estimated by comparing outcomes of patients treated with first-line dacarbazine over the period 2007-2009 with patients treated over the period 2010-2015 with first-line ipilimumab. Read More

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http://dx.doi.org/10.1097/CMR.0000000000000582DOI Listing
February 2019

Confirmed Case of Buruli Ulcer, Senegal, 2018.

Emerg Infect Dis 2019 Mar;25(3):600-601

Buruli ulcer is a necrotizing skin disease caused by Mycobacterium ulcerans and is usually associated with tropical climates and exposure to slow-moving or stagnant water. We report a case of Buruli ulcer that may have originated in an urban semiarid area of Senegal. Read More

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http://dx.doi.org/10.3201/eid2503.180707DOI Listing

Role of the endocannabinoid system in the dorsal hippocampus in the cardiovascular changes and delayed anxiety-like effect induced by acute restraint stress in rats.

J Psychopharmacol 2019 Feb 21:269881119827799. Epub 2019 Feb 21.

1 Department of Pharmacology, Medical School of Ribeirão Preto, University of São Paulo (FMRP-USP), Ribeirão Preto, São Paulo, Brazil.

Background:: The dorsal hippocampus has a central role in modulating cardiovascular responses and behavioral adaptation to stress. The dorsal hippocampus also plays a key role in stress-associated mental disorders. The endocannabinoid system is widely expressed in the dorsal hippocampus and modulates defensive behaviors under stressful conditions. Read More

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http://dx.doi.org/10.1177/0269881119827799DOI Listing
February 2019

MIG in Cutaneous Systemic Lupus Erythematosus.

Authors:
I Ruffilli

Clin Ter 2019 Jan-Feb;170(1):e71-e76

Department of Clinical and Experimental Medicine, University of Pisa, Italy.

Many studies reported that monokine induced by interferon (IFN)-γ(MIG), and its receptor chemokine (C-X-C motif) receptor (CXCR)3, are expressed by T cells in different types of cutaneous damages associated with lupus, and that the CXCR3-activating chemokines are produced locally, suggesting that they play a significant role in the recruitment of T cells in these inflammatory lesions. Circulating MIG levels are increased in cutaneous Systemic Lupus Erythematosus (SLE) patients and strongly correlated with the disease activity. The data discussed in this review show that there is an increasing evidence that MIG may participate in the pathogenesis of a variety of the manifestations of cutaneous SLE, even if the exact role of MIG in the pathogenesis of this disease remains to be clarified. Read More

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http://dx.doi.org/10.7417/CT.2019.2111DOI Listing
February 2019

Clinical and immunological effects of a treatment with desentizating low-dose multicomponents in IgE mediated and non IgE mediated food allergies: observational retrospective pilot study.

Clin Ter 2019 Jan-Feb;170(1):e10-e15

Department of Pediatric Allergology, Nuovo Regina Margherita Hospital, Rome, Italy.

Background: Alimentary allergy has high impact on the quality of life (Qol) of patients and their families: it represents an economic burden for individuals and National Health System. The disease, particularly frequent in pediatric age, recognizes different pathogenetic mechanisms and expresses itself through the production of IgE (IgE mediated form) antibodies or through cell-mediated immunune responses (non IgE mediated forms). The aim of this clinical observational retrospective study is to evaluate the effect of a long-term treatment with Low Dose Medicine (LDM) drugs in pediatric patients affected by IgE and non IgE mediated food allergy. Read More

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http://dx.doi.org/10.7417/CT.2019.2102DOI Listing
February 2019

Cutaneous Chromoblastomycosis: A Prototypal Case.

J Cutan Med Surg 2019 Jan/Feb;23(1):98

2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1177/1203475418789029DOI Listing
February 2019

Antibiotics for Prevention of Postoperative Infection From Mohs on the Leg: A Survey of the American College of Mohs Surgery.

J Cutan Med Surg 2019 Jan/Feb;23(1):121-122

1 Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1177/1203475418800944DOI Listing
February 2019

Dasatinib for chronic myelogenous leukemia improves skin symptoms of systemic sclerosis.

Int J Hematol 2019 Feb 20. Epub 2019 Feb 20.

Department of Hematology, Ome Municipal General Hospital, 4-16-5, Higashiome, Ome, Tokyo, Japan.

A 64-year-old man was diagnosed with limited cutaneous systemic sclerosis 5 years prior to this report. His sclerotic skin symptoms did not respond to oral low-dose prednisone (5-10 mg/day). Five years after the diagnosis, the patient presented with leukocytosis 3. Read More

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http://dx.doi.org/10.1007/s12185-019-02618-wDOI Listing
February 2019

Lymph node ratio has impact on relapse and outcome in patients with stage III melanoma.

Int J Clin Oncol 2019 Feb 20. Epub 2019 Feb 20.

Department of Medical Oncology, Institute of Oncology, University of Istanbul, 34390, Istanbul, Capa, Turkey.

Background: Even though both the involvement of regional lymph nodes and the number of metastatic lymph nodes are regarded as major determinants of survival in cutaneous melanoma, the extent of node dissection has been analyzed as an independent prognostic indicator in only a few studies. This study aims to determine how the lymph node ratio (NR) (ratio of positive nodes to total nodes removed) might predict the disease relapse and survival in node-positive melanoma.

Materials And Methods: A total of 317 patients with stage III primary melanoma were included in the study and reviewed retrospectively. Read More

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http://dx.doi.org/10.1007/s10147-019-01410-4DOI Listing
February 2019

A pilot study on aesthetic treatments performed by qualified aesthetic practitioners: efficacy on health-related quality of life in breast cancer patients.

Qual Life Res 2019 Feb 20. Epub 2019 Feb 20.

Department of Oncology and Hematoncology (DIPO), University of Milan, Via Festa del Perdono 7, 20122, Milan, Italy.

Purpose: Cancer treatments often produce undesirable side-effects, such as skin toxicity, impacting on everyday functioning and health-related quality of life (HRQoL). This experimental study sought to determine whether aesthetic products and treatments could significantly decrease perceived skin symptoms, psychological distress and improve skin-related QoL (SRQoL).

Methods: An experimental group composed of 100 breast patients was enrolled for specialized aesthetic treatments at the European Institute of Oncology (IEO) and compared to a control group of 70 breast patients who did not receive any aesthetic treatment. Read More

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http://dx.doi.org/10.1007/s11136-019-02133-9DOI Listing
February 2019

Simultaneous polychromatic flow cytometric detection of multiple forms of regulated cell death.

Apoptosis 2019 Feb 20. Epub 2019 Feb 20.

Flow Cytometry Core Facility, The Blizard Institute, Barts and The London School of Medicine and Dentistry, Queen Mary London University, 4 Newark Street, London, E1 2AT, UK.

Currently the study of Regulated Cell Death (RCD) processes is limited to the use of lysed cell populations for Western blot analysis of each separate RCD process. We have previously shown that intracellular antigen flow cytometric analysis of RIP3, Caspase-3 and cell viability dye allowed the determination of levels of apoptosis (Caspase-3/RIP3), necroptosis (RIP3/Caspase-3) and RIP1-dependent apoptosis (Caspase-3/RIP3) in a single Jurkat cell population. The addition of more intracellular markers allows the determination of the incidence of parthanatos (PARP), DNA Damage Response (DDR, H2AX), H2AX hyper-activation of PARP (H2AX/PARP) autophagy (LC3B) and ER stress (PERK), thus allowing the identification of 124 sub-populations both within live and dead cell populations. Read More

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http://dx.doi.org/10.1007/s10495-019-01528-wDOI Listing
February 2019

Epidemiological Survey of Human Dermatophytosis due to Zoophilic Species in Tehran, Iran.

Iran J Public Health 2018 Dec;47(12):1930-1936

School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.

Background: Dermatophytosis is known as one of the most frequent cutaneous infections that lead to public health problems to human and animals. The purpose of this study was to determine the prevalence of human dermatophytosis due to zoophilic species in Tehran, Iran from 2014 to 2015.

Methods: Overall, 3989 patients with clinically suspected fungal infections were studied. Read More

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December 2018

Allergy in total knee replacement surgery: Is it a real problem?

World J Orthop 2019 Feb 18;10(2):63-70. Epub 2019 Feb 18.

Department of Orthopaedics and Traumatology, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome 00168, Italy.

Total knee arthroplasty is a common procedure, with extremely good clinical results. Despite this success, it produces 20% unsatisfactory results. Among the causes of these failures is metal hypersensitivity. Read More

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http://dx.doi.org/10.5312/wjo.v10.i2.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6379738PMC
February 2019

Treatment outcomes of patients with localized anal squamous cell carcinoma according to HIV infection: systematic review and meta-analysis.

J Gastrointest Oncol 2019 Feb;10(1):48-60

Department of Clinical Oncology, A.C. Camargo Cancer Center, Sao Paulo, SP, Brazil.

Background: Definitive chemoradiation (CRT) is the standard treatment for localized squamous cell carcinoma of the anus (SCCA). Because most phase III trials in SCCA have excluded patients with HIV, the evidence on treatment outcomes of these patients is lacking. We performed a systematic review and meta-analysis on the efficacy and toxicity profiles of HIV-positive SCCA patients treated with definitive CRT. Read More

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http://dx.doi.org/10.21037/jgo.2018.10.08DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6351309PMC
February 2019

Glucose as a cause of and treatment for cutaneous necrosis.

J Vasc Bras 2018 Oct-Dec;17(4):341-347

Pontifícia Universidade Católica de Goiás - PUC Goiás, Goiânia, GO, Brasil.

Sclerotherapy remains one of the procedures most frequently performed by Brazilian vascular surgeons. Knowledge of its complications is indispensable to enable us to avoid them. The severe side effects of this method of treatment for telangiectasias of the lower limbs are rare and are often associated with technical errors or the dose injected. Read More

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http://dx.doi.org/10.1590/1677-5449.004818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6375268PMC
February 2019

Cutaneous Polyarteritis Nodosa Treated with Pentoxifylline and Clobetasol Propionate: A Case Report.

Saudi J Med Med Sci 2018 May-Aug;6(2):104-107. Epub 2018 Apr 16.

Department of Dermatology, King Fahd Hospital of the University, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.

Cutaneous polyarteritis nodosa is a rare type of cutaneous vasculitis. It affects the small- and medium-sized arteries of the dermis and subcutaneous tissue without extracutaneous involvement. The diagnosis is by skin biopsy, and the characteristic finding is a leukocytoclastic vasculitis. Read More

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http://dx.doi.org/10.4103/sjmms.sjmms_148_16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6196709PMC

Sodium chloride is an ionic checkpoint for human T2 cells and shapes the atopic skin microenvironment.

Sci Transl Med 2019 Feb;11(480)

Institute of Virology, Technical University of Munich, 81675 Munich, Germany.

The incidence of allergic diseases has increased over the past 50 years, likely due to environmental factors. However, the nature of these factors and the mode of action by which they induce the type 2 immune deviation characteristic of atopic diseases remain unclear. It has previously been reported that dietary sodium chloride promotes the polarization of T helper 17 (T17) cells with implications for autoimmune diseases such as multiple sclerosis. Read More

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http://dx.doi.org/10.1126/scitranslmed.aau0683DOI Listing
February 2019

AIDS-Related Kaposi Sarcoma, Version 2.2019, NCCN Clinical Practice Guidelines in Oncology.

J Natl Compr Canc Netw 2019 Feb;17(2):171-189

UC San Diego Moores Cancer Center; Duke Cancer Institute; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Massachusetts General Hospital Cancer Center; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Fox Chase Cancer Center; University of Wisconsin Carbone Cancer Center; Huntsman Cancer Institute at the University of Utah; University of Michigan Rogel Cancer Center; Stanford Cancer Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Yale Cancer Center/Smilow Cancer Hospital; The University of Texas MD Anderson Cancer Center; Dana-Farber/Brigham and Women's Cancer Center; Fred & Pamela Buffett Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Vanderbilt-Ingram Cancer Center; City of Hope National Medical Center; Memorial Sloan Kettering Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Mayo Clinic Cancer Center; Moffitt Cancer Center; HIV + Aging Research Project - Palm Springs; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; UCSF Helen Diller Family Comprehensive Cancer Center; Roswell Park Comprehensive Cancer Center; and National Comprehensive Cancer Network.

As treatment of HIV has improved, people living with HIV (PLWH) have experienced a decreased risk of AIDS and AIDS-defining cancers (non-Hodgkin's lymphoma, Kaposi sarcoma, and cervical cancer), but the risk of Kaposi sarcoma in PLWH is still elevated about 500-fold compared with the general population in the United States. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for AIDS-Related Kaposi Sarcoma provide diagnosis, treatment, and surveillance recommendations for PLWH who develop limited cutaneous Kaposi sarcoma and for those with advanced cutaneous, oral, visceral, or nodal disease. Read More

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http://dx.doi.org/10.6004/jnccn.2019.0008DOI Listing
February 2019

Response to Anti-PD-1 in Uveal Melanoma Without High-Volume Liver Metastasis.

J Natl Compr Canc Netw 2019 Feb;17(2):114-117

Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee; Department of Medicine, University of Chicago, Chicago, Illinois; Department of Ophthalmology, Vanderbilt University Medical Center, Nashville, Tennessee; and Department of Medicine, Robert H. Lurie Cancer Center and Northwestern University, Chicago, Illinois.

Uveal melanoma (UM) is an uncommon melanoma subtype with poor prognosis. Agents that have transformed the management of cutaneous melanoma have made minimal inroads in UM. We conducted a single-arm phase II study of pembrolizumab in patients with metastatic UM and performed bioinformatics analyses of publicly available datasets to characterize the activity of anti-PD-1 in this setting and to understand the mutational and immunologic profile of this disease. Read More

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http://dx.doi.org/10.6004/jnccn.2018.7070DOI Listing
February 2019

Cardiovascular, antidepressant and immunosuppressive drug use in relation to risk of cutaneous melanoma: a protocol for a prospective case-control study.

BMJ Open 2019 Feb 20;9(2):e025246. Epub 2019 Feb 20.

Department of Research, Kreftregisteret, Oslo, Norway.

Introduction: The incidence of cutaneous melanoma (hereafter melanoma) has increased dramatically among fair-skinned populations worldwide. In Norway, melanoma is the most rapidly growing type of cancer, with a 47% increase among women and 57% among men in 2000-2016. Intermittent ultraviolet exposure early in life and phenotypic characteristics like a fair complexion, freckles and nevi are established risk factors, yet the aetiology of melanoma is multifactorial. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-025246DOI Listing
February 2019

Recent advances in localized immunotherapy of skin cancers.

Immunotherapy 2019 Apr;11(5):443-456

Unit of Dermatology, University of Padua, Via Gallucci 4, Padova 35128, Italy.

Skin cancer is the most frequent malignancy in humans. The immune system has long been known to have an important role in defeating cancer. Immunotherapy, which includes various strategies to enhance tumor immunity, currently represents an exciting option for the treatment of skin cancers. Read More

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http://dx.doi.org/10.2217/imt-2018-0139DOI Listing

Pediatric Acral Angioleiomyoma: Report of an Unusual Case and Review of the Literature.

Fetal Pediatr Pathol 2019 Feb 20:1-6. Epub 2019 Feb 20.

b Princess Alexandra Hospital , Pathology Queensland , Woolloongabba , Australia.

Background: Angioleiomyoma is a classic painful cutaneous tumor of the limbs of middle aged adults. They are usually a straight-forward histologic diagnosis, being well-circumscribed or encapsulated lesions with both smooth muscle and vascular components.

Case Report: We report the case of an angioleiomyoma on the toe of an 8-year-old girl which displayed an unusual plexiform growth pattern. Read More

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http://dx.doi.org/10.1080/15513815.2019.1576819DOI Listing
February 2019