119 results match your criteria Cutaneous Kikuchi Disease


Low-Dose Erlotinib Treatment in Elderly or Frail Patients With EGFR Mutation-Positive Non-Small Cell Lung Cancer: A Multicenter Phase 2 Trial.

JAMA Oncol 2020 May 14:e201250. Epub 2020 May 14.

Department of Respiratory Medicine and Medical Oncology, Yokohama Municipal Citizen's Hospital, Yokohama, Japan.

Importance: Although the efficacy of epidermal growth factor receptor tyrosine kinase inhibitors for EGFR gene mutation-positive non-small cell lung cancer is well established, optimal dosing remains to be established, especially in elderly or frail patients.

Objective: To investigate the efficacy and safety of low-dose erlotinib in elderly or frail patients with EGFR mutation-positive non-small cell lung cancer.

Design, Setting, And Participants: Single-arm phase 2 trial with the Southwest Oncology Group (SWOG) 2-stage design that enrolled frail patients from 21 Japanese institutions after meeting the inclusion criteria. Read More

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http://dx.doi.org/10.1001/jamaoncol.2020.1250DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7226294PMC

A Case of Kikuchi-Fujimoto Disease Associated with Erosive Lichen Planus.

Cureus 2020 Mar 18;12(3):e7312. Epub 2020 Mar 18.

Department of Dermatology, College of Medicine, King Saud University, Riyadh, SAU.

Kikuchi-Fujimoto disease (KFD), also known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting disorder with unknown etiology. The most frequent clinical manifestations include lymphadenopathy, fever, cutaneous lesions, arthritis, fatigue, and hepatosplenomegaly. Cutaneous manifestations of KFD, occurring in about one-third of patients, are typically non-specific, rarely presenting as symmetrically distributed lesions. Read More

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http://dx.doi.org/10.7759/cureus.7312DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7164705PMC

Human proliferative sparganosis update.

Parasitol Int 2020 Apr 10;75:102036. Epub 2019 Dec 10.

Department of Infectious Diseases, Division of Parasitology, Faculty of Medicine, University of Miyazaki, Japan. Electronic address:

Proliferative sparganosis is one of the most bizarre and mysterious parasitic diseases ever described. The causative parasite is Sparganum proliferum, which is a pseudophyllidean cestode distinct from Spirometra tapeworms. Here we overview this rare but fascinating disease with the all original case reports on human patients published in the last 115 years. Read More

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http://dx.doi.org/10.1016/j.parint.2019.102036DOI Listing

Skin Biopsy in the Context of Systemic Disease.

Actas Dermosifiliogr 2019 Nov 4;110(9):710-727. Epub 2019 Jun 4.

Servicio de Anatomía Patológica, Hospital El Bierzo, Ponferrada, León, España; Instituto de Investigación Biomédica de A Coruña, Grupo de Investigación CellCOM-SB, A Coruña, España; Servicio de Anatomía Patológica, Hospital de la Reina, Ponferrada, León, España. Electronic address:

The skin is the largest and most exposed organ in the human body and the ideal place to look for signs that aid in the early diagnosis of systemic diseases with cutaneous effects. As the concepts that underpin our understanding of many of these diseases have evolved or expanded in recent years, there have also been changes in the criteria we use for early diagnosis, including our approaches to skin biopsy and dermatopathologic evaluation. This review focuses on some of the systemic processes with skin manifestations for which our basic understanding has changed most in recent decades. Read More

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http://dx.doi.org/10.1016/j.ad.2019.02.012DOI Listing
November 2019
11 Reads

Cutaneous lupus with Kikuchi disease-like inflammatory pattern associated with myelodysplastic syndrome.

Rheumatology (Oxford) 2019 03;58(3):554-556

Department of Internal Medicine, APHP, Saint Antoine Hospital, Sorbonne Université, France.

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http://dx.doi.org/10.1093/rheumatology/key413DOI Listing
March 2019
30 Reads

Kikuchi's disease (histiocytic necrotizing lymphadenitis): A rare presentation with acute kidney injury, peripheral neuropathy, and aseptic meningitis with cutaneous involvement.

Indian J Pathol Microbiol 2018 Jan-Mar;61(1):113-115

Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Wardha, Maharashtra, India.

Kikuchi's disease (KD) also known as histiocytic necrotizing lymphadenitis is rare, idiopathic, generally self-limited cause of lymphadenitis. We present a case of twenty year young female who presented in critically ill state with fever, cervical and axillary lymphadenopathy, rash, vomiting and altered sensorium and found to have neurological, hepatic, renal and dermatological involvement. Kikuchi's disease should be considered in differential diagnosis of fever and lymphadenopathy and though benign can sometimes present with multi-organ involvement. Read More

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http://dx.doi.org/10.4103/IJPM.IJPM_256_17DOI Listing
November 2018
6 Reads

A case of sigmoid colon adenocarcinoma diagnosed as facial cutaneous metastasis for survival after operation for 37 months.

Clin J Gastroenterol 2017 Oct 3;10(5):420-425. Epub 2017 Aug 3.

Department of Surgery, Nippon Medical School, Tokyo, Japan.

Cutaneous metastasis of an internal malignancy is uncommon and is estimated to occur in 0.7-9% of patients with internal cancer including autopsy cases. We would like to report a case of long survival of sigmoid colon adenocarcinoma diagnosed as an instance of facial cutaneous metastasis. Read More

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http://dx.doi.org/10.1007/s12328-017-0767-7DOI Listing
October 2017
40 Reads

Epidemiology and Characteristics of Kikuchi-Fujimoto Disease in the African-Descent Population of Martinique, French West Indies.

Arthritis Care Res (Hoboken) 2016 12 21;68(12):1883-1887. Epub 2016 Oct 21.

Centre Hospitalier Universitaire Pierre Zobda Quitman, Fort de France, Martinique.

Objective: To provide an epidemiologic description of Kikuchi-Fujimoto disease (KFD), and to describe its relationship with systemic lupus erythematosus (SLE) in a population of sub-Saharan origin.

Methods: Patients were retrospectively included on the basis of lymph node histology compatible with KFD reported in Martinique from 1991 until 2013. In order to describe the characteristics of the disease in a larger cohort, we subsequently included more patients of Afro-Caribbean origin from Guadeloupe and French Guiana. Read More

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http://dx.doi.org/10.1002/acr.22898DOI Listing
December 2016
41 Reads

Kikuchi-Fujimoto disease: a diagnostic dilemma.

Int J Dermatol 2016 Oct 21;55(10):1069-75. Epub 2016 May 21.

Dermatology, Rutgers New Jersey Medical School and Rutgers University School of Public Affairs and Administration, Newark, NJ, USA.

Kikuchi-Fujimoto disease is a benign, self-limiting condition characterized by lymphadenopathy and fever. Its diagnosis can be challenging, as the disease must be differentiated from lymphoma and systemic lupus erythematosus. Patients can present with nonspecific cutaneous lesions. Read More

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http://dx.doi.org/10.1111/ijd.13314DOI Listing
October 2016
52 Reads

Thymoma-associated cutaneous graft-versus-host-like disease possibly treated with Narrow-band UVB phototherapy.

Eur J Dermatol 2016 Apr;26(2):208-9

Department of Dermatology The Jikei University School of Medicine 3-25-8 Nishishimbashi, Minato-ku, Tokyo, JAPAN 106-8461.

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http://dx.doi.org/10.1684/ejd.2015.2716DOI Listing
April 2016
20 Reads

Anti-RNA polymerase III antibody-associated scleroderma renal crisis in a patient with limited cutaneous systemic sclerosis: A case report.

Mod Rheumatol 2018 Mar 4;28(2):369-372. Epub 2016 Mar 4.

a Nephrology Center, Toranomon Hospital , Japan.

A 69-year-old Japanese man was presented with hypertensive crisis. Renal histology revealed malignant nephrosclerosis, including an onion skin pattern with fibrinoid necrosis of the small arteries from arterioles up to interlobular arteries. Immunological investigation clarified positive anti-RNA polymerase (RNAP) III antibody, and limited cutaneous systemic sclerosis (Lc SSc) was diagnosed by skin biopsy as the underlying disease causing scleroderma renal crisis (SRC). Read More

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http://dx.doi.org/10.3109/14397595.2015.1112873DOI Listing
March 2018
28 Reads

Simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn's disease during infliximab therapy.

BMC Pulm Med 2016 Feb 11;16:30. Epub 2016 Feb 11.

Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, 980-8574, Japan.

Background: Paradoxical inflammations during anti-TNF-α therapy are defined as adverse effects such as psoriasiform skin lesions, uveitis and sarcoidosis-like granulomas induced by immune reactions, not by infectious agents. Here, we report a very rare case of the simultaneous development of sarcoidosis and cutaneous vasculitis in a patient with refractory Crohn's disease during infliximab therapy and both of which resolved spontaneously without the cessation of infliximab.

Case Presentation: In September 2000, 23-year old Japanese male was diagnosed with Crohn's disease. Read More

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http://dx.doi.org/10.1186/s12890-016-0193-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750217PMC
February 2016
45 Reads

Kikuchi-Fujimoto Disease Associated With Subcutaneous Panniculitis-Like T-Cell Lymphoma.

Am J Dermatopathol 2016 Jun;38(6):e77-80

*Division of Dermatology, Department of Medicine, University of Washington, Seattle, WA; †Division of Hematology, Department of Medicine, University of Washington, Seattle, WA; ‡Division of Hematopathology, Department of Pathology, University of Washington, Seattle, WA; and §Division of Dermatopathology, Department of Pathology, University of Washington, Seattle, WA.

Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is a variant of cutaneous T-cell lymphoma that can mimic inflammatory panniculitis, particularly lupus erythematosus panniculitis, clinically and histologically. Patients with SPTL generally have a benign course, though SPTL can be complicated by hemophagocytic syndrome, which can negatively impact prognosis. We report a patient with recurrent SPTL and hemophagocytic syndrome accompanied by a necrotizing lymphadenitis consistent with Kikuchi-Fujimoto disease. Read More

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http://dx.doi.org/10.1097/DAD.0000000000000486DOI Listing
June 2016
14 Reads

Kikuchi Disease-Like Inflammatory Pattern in Cutaneous Inflammatory Infiltrates Without Lymph Node Involvement: A New Clue for the Diagnosis of Lupus?

Medicine (Baltimore) 2015 Nov;94(46):e2065

From the Department of Internal Medicine (L-HT, BG, NL); Department of Dermatology (SI-H-O, PW, OC); Department of Pathology (NO), AP-HP, CHU Henri-Mondor, UPEC University; EA EpiDermE (Epidemiology in Dermatology and Evaluation of Therapeutics), INSERM, CIC 1430 (SI-H-O, PW, OC); INSERM U955 team 9, Créteil (NO); C. Cap Orléans Laboratory, Orléans (LR, JK); and Department of Dermatology, CHG de Dreux, Dreux, France (VP).

Kikuchi-Fujimoto disease (KFD) is a rare and benign disorder that usually occurs in young adults with enlarged lymph nodes containing infiltrate of cytotoxic T cells and nuclear debris. It can be a manifestation of systemic lupus erythematosus (SLE) although the strength of this association has varied among studies. Although specific KFD cutaneous lesions are well described, pure cutaneous lesions have never been reported. Read More

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http://dx.doi.org/10.1097/MD.0000000000002065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4652827PMC
November 2015
76 Reads

Kikuchi's disease of the xanthomathous type with cutaneous manifestations.

An Bras Dermatol 2015 Mar-Apr;90(2):245-7

Hospital de Braga, Braga, Portugal.

Kikuchi's disease is a benign, self-limiting disease, whose pathogenesis remains unknown. Patients most often present with cervical lymphadenopathy, sometimes associated with fever and leukopenia. It has been reported that up to 40% of patients with Kikuchi's disease have also cutaneous eruptions, but no specific skin changes have been described. Read More

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http://dx.doi.org/10.1590/abd1806-4841.20153228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4371676PMC
July 2015
28 Reads

Transplanted bone marrow-derived circulating PDGFRα+ cells restore type VII collagen in recessive dystrophic epidermolysis bullosa mouse skin graft.

J Immunol 2015 Feb 19;194(4):1996-2003. Epub 2015 Jan 19.

Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita 565-0871, Japan;

Recessive dystrophic epidermolysis bullosa (RDEB) is an intractable genetic blistering skin disease in which the epithelial structure easily separates from the underlying dermis because of genetic loss of functional type VII collagen (Col7) in the cutaneous basement membrane zone. Recent studies have demonstrated that allogeneic bone marrow transplantation (BMT) ameliorates the skin blistering phenotype of RDEB patients by restoring Col7. However, the exact therapeutic mechanism of BMT in RDEB remains unclear. Read More

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http://dx.doi.org/10.4049/jimmunol.1400914DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319308PMC
February 2015
21 Reads

A case of Kikuchi's disease (histiocytic necrotizing lymphoadenitis) with histiocytic cutaneous involvement.

Rheumatol Int 2015 Jun 25;35(6):1111-3. Epub 2014 Nov 25.

Department of Dermatology, Kitasato University School of Medicine, 1-15-1 Kitasato, Sagamihara, Kanagawa, 252-0374, Japan,

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http://dx.doi.org/10.1007/s00296-014-3184-yDOI Listing
June 2015
19 Reads

Cutaneous lesions of Kikuchi's disease: evolution of histopathological findings.

J Dermatol 2014 Aug 9;41(8):736-8. Epub 2014 Jul 9.

Department of Dermatology, Asahikawa Medical University, Asahikawa, Japan.

We report a 38-year-old male patient who presented with cutaneous lesions mimicking widespread discoid lupus erythematosus with high-grade fever, arthralgia and lymphadenopathy. Additional lymph node and skin biopsies, however, revealed karyorrhectic debris without neutrophils and numerous CD68-positive cells, a characteristic finding of Kikuchi's disease (KD). Comparing skin biopsies on different occasions, we could see different forms of histopathology. Read More

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http://dx.doi.org/10.1111/1346-8138.12557DOI Listing
August 2014
12 Reads

Persistent pruritic papules and plaques associated with adult-onset Still's disease: report of six cases.

J Dermatol 2014 May 15;41(5):407-10. Epub 2014 Mar 15.

Department of Dermatology, Fukushima Medical University, Fukushima, Japan.

Typical skin rash, which appears and disappears along with respective rise and fall of fever, is well-known, and included as one of the major criteria of adult-onset Still's disease (AOSD) (Yamaguchi's criteria). In addition, various skin lesions are occasionally observed in association with AOSD. Persistent pruritic eruptions present with some clinical features, such as urticarial erythema, flagellate erythema, erythematous, slightly scaly or crusted papules, and/or plaques on the trunk and extremities. Read More

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http://dx.doi.org/10.1111/1346-8138.12426DOI Listing
May 2014
69 Reads

Exacerbation of pemphigus foliaceus after electron-beam radiation.

Acta Derm Venereol 2014 Nov;94(6):729-30

Department of Dermatology, Sapporo City General Hospital North 11, West 13, Chou-ku, Sapporo 060-8604, Japan.

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http://dx.doi.org/10.2340/00015555-1811DOI Listing
November 2014
7 Reads

Subacute cutaneous lupus erythematosus onset preceded by Kikuchi-Fujimoto disease.

Dermatol Pract Concept 2014 Jan 31;4(1):47-9. Epub 2014 Jan 31.

Pathology Unit, Arcispedale Santa Maria Nuova-IRCCS, Reggio Emilia, Italy.

Kikuchi-Fujimoto disease (KFD) is an uncommon clinicopathological entity characterized by fever and lymphadenopathy, predominantly involving cervical lymph nodes, accompanied by chills and leukopenia. The diagnosis relies primarily on the presence of typical morphological features in the swelling lymph nodes. KFD can occur as a benign and self-limiting lymphadenopathy, but it can sporadically precede, postdate or coincide with the diagnosis of systemic lupus erythematosus (SLE). Read More

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http://dx.doi.org/10.5826/dpc.0401a06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919839PMC
January 2014
7 Reads

Mimics of cutaneous lymphoma: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop.

Am J Clin Pathol 2013 Apr;139(4):536-51

AS-255C, UCLA Medical Center, CHS, 10833 LeConte Ave, Los Angeles, CA 90095, USA.

The Society for Hematopathology and European Association for Haematopathology workshop, from October 27 to 29, 2011, in Los Angeles, CA, exhibited many exemplary skin biopsy specimens with interesting inflammatory changes mimicking features of cutaneous lymphoma. This article reviews features observed in cutaneous lymphoid hyperplasia, cutaneous drug reactions, lupus-associated panniculitis, pityriasis lichenoides, hypereosinophilic syndrome, histiocytic necrotizing lymphadenitis, traumatic ulcerative granuloma with stromal eosinophils, and pigmented purpuric dermatosis, as well as a brief review of the pertinent literature and discussion of submitted conference cases. For the pathologist, it is important to be aware of diagnostic pitfalls as well as the limitations of ancillary testing (eg, clonality studies). Read More

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https://academic.oup.com/ajcp/article/139/4/536/1761353
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http://dx.doi.org/10.1309/AJCPX4BXTP2QBRKODOI Listing
April 2013
30 Reads

[An atypical presentation of Kikuchi-Fujimoto disease].

Rev Med Interne 2013 Jun 29;34(6):373-6. Epub 2012 Nov 29.

Service de médecine interne A, hôpital Lariboisière, université Paris Cité-Diderot, AP-HP, 2, rue Ambroise-Paré, 75010 Paris, France.

Introduction: Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease) is a rare clinical entity characterized by the association of enlarged lymph nodes in the posterior cervical region and fever. The disease is more frequent in young women.

Case Report: We report a 41-year-old African patient who presented with atypical features of Kikuchi's disease including cutaneous lupus, haemophagocytosis, and lymphocytic meningitis. Read More

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http://dx.doi.org/10.1016/j.revmed.2012.11.002DOI Listing
June 2013
10 Reads

Tuberculous cellulitis in a patient with chronic kidney disease and polymyalgia rheumatica.

Intern Med 2012 15;51(22):3203-6. Epub 2012 Nov 15.

Department of Internal Medicine, Mishuku Hospital, Japan.

An 89-year-old man with advanced renal failure, polymyalgia rheumatica and a past history of tuberculosis was admitted with a high fever. Erythema and swelling appeared in the femoral region. Since the cellulitis failed to respond to antibiotic therapy, a skin biopsy was performed. Read More

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http://dx.doi.org/10.2169/internalmedicine.51.8494DOI Listing
May 2013
17 Reads

Kikuchi-Fujimoto disease with cutaneous presentation in a patient with subacute cutaneous lupus erythematosus.

Dermatol Online J 2012 Sep 15;18(9). Epub 2012 Sep 15.

Department of Dermatology, Westmead Hospital, Westmead, New South Wales, Australia.

We report the case of a 45-year-old female patient previously diagnosed with subacute cutaneous lupus erythematosus who presented with a one-week history of fever, tender erythematous nodules on her limbs, and palpable lymphadenopathy. Two incisional biopsies showed histiocytic infiltrates with abundant nuclear debris in the dermis and at the dermosubcutaneous junction with absence of neutrophils, characteristic of Kikuchi-Fujimoto disease (KFD). The dermatologic and dermopathologic details of KFD are very heterogeneous and yet poorly described. Read More

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September 2012
15 Reads

Cutaneous manifestation of Kikuchi-Fujimoto disease in the setting of granulomatosis with polyangiitis (Wegener's).

J Gen Intern Med 2012 Sep 7;27(9):1220-2. Epub 2012 Mar 7.

Department of Internal Medicine, West Penn Allegheny Health System, Pittsburgh, PA 15212, USA.

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http://dx.doi.org/10.1007/s11606-012-2026-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3514983PMC
September 2012
15 Reads

Cutaneous Kikuchi disease-like eruption presenting as a paraneoplastic syndrome.

Clin Exp Dermatol 2012 Mar;37(2):207-9

Dermatology Department, Royal Infirmary of Edinburgh, Lothian University Hospital Division, Edinburgh, UK.

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http://dx.doi.org/10.1111/j.1365-2230.2011.04139.xDOI Listing
March 2012
5 Reads

Cutaneous manifestations associated with adult-onset Still's disease: important diagnostic values.

Rheumatol Int 2012 Aug 25;32(8):2233-7. Epub 2011 Dec 25.

Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima 960-1295, Japan.

Adult-onset Still's disease (AOSD) is a systemic inflammatory condition, characterized by a high spiking fever, leukocytosis with neutrophilia, arthralgia, and skin rash. Typical skin rash is an evanescent, salmon-pink erythema predominantly involving extremities, which is included as one of the diagnostic criteria; however, recent findings show that not only typical evanescent rash but also various skin lesions are associated with AOSD. The representative characteristic skin lesion among the non-classical skin rash is called persistent pruritic papules and plaques, which presents erythematous, slightly scaly papules with linear configuration on the trunk. Read More

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http://dx.doi.org/10.1007/s00296-011-2330-zDOI Listing
August 2012
16 Reads

Histiocytic necrotizing lymphadenitis in the context of systemic lupus erythematosus (SLE): Is histiocytic necrotizing lymphadenitis in SLE associated with skin lesions?

Lupus 2011 Jul 11;20(8):809-19. Epub 2011 May 11.

Department of Internal Medicine, Arthritis and Autoimmunity Research Center, Catholic University of Daegu School of Medicine, Daegu, South Korea.

Histiocytic necrotizing lymphadenitis (HNL), or Kikuchi's disease, is a benign and self-limiting lymphadenopathy that typically affects young Asian females. It presents with lymphadenopathy, usually cervical, accompanied by fever, chills and leukopenia. Although the association between systemic lupus erythematosus (SLE) and HNL is rare, the number of reports of HNL in SLE patients is increasing. Read More

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http://journals.sagepub.com/doi/10.1177/0961203310397684
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http://dx.doi.org/10.1177/0961203310397684DOI Listing
July 2011
7 Reads

Exogenous coproporphyrin III production by Corynebacterium aurimucosum and Microbacterium oxydans in erythrasma lesions.

J Med Microbiol 2011 Jul 10;60(Pt 7):1038-1042. Epub 2011 Mar 10.

Department of Biological Information, Graduate School of Biotechnology, Tokyo Institute of Technology, Midori-ku, Yokohama, Japan.

Erythrasma is a superficial skin disease caused by Gram-positive Corynebacterium species. Coral-red fluorescence under Wood's light, strongly suggestive of erythrasma, can be attributed to the presence of porphyrins. Fractionated porphyrin analysis in erythrasma lesions is yet to be reported. Read More

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http://dx.doi.org/10.1099/jmm.0.027276-0DOI Listing
July 2011
117 Reads

Whole-body 18F-fluorodeoxyglucose positron emission tomography/computed tomography images before and after chemotherapy for Kaposi sarcoma and highly active antiretrovirus therapy.

Jpn J Radiol 2010 Dec 30;28(10):759-62. Epub 2010 Dec 30.

Division of Nuclear Medicine, Department of Radiology, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.

Kaposi sarcoma is an acquired immunodeficiency syndrome-related disease that mainly involves the skin, gastrointestinal gut, and lungs. Whole-body 18F-fluorodeoxyglucose-positron emission tomography and computed tomography (FDG-PET/CT) scanning is useful for simultaneous detection of multiple lesions of Kaposi sarcoma. We present a 67-year-old man with a history of infection with human immunodeficiency virus who presented with numerous cutaneous lesions. Read More

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http://dx.doi.org/10.1007/s11604-010-0481-6DOI Listing
December 2010
23 Reads

Acute right heart failure and achalasia-like syndrome in a patient with limited cutaneous systemic sclerosis and primary biliary cirrhosis.

Intern Med 2010 13;49(16):1779-82. Epub 2010 Aug 13.

Department of Internal Medicine, Takanoko Hospital, Matsuyama, Japan.

We report a case of a 63-year-old woman who developed acute right heart failure and an achalasia-like syndrome with limited cutaneous systemic sclerosis (lcSSc) and primary biliary cirrhosis. Intravenous administration of diuretics improved her acute heart failure. Anti-centromere antibodies and anti-mitochondria antibodies were present. Read More

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http://dx.doi.org/10.2169/internalmedicine.49.3640DOI Listing
May 2011
8 Reads

Overview of common, rare and atypical manifestations of cutaneous lupus erythematosus and histopathological correlates.

Lupus 2010 Aug;19(9):1050-70

Baylor Institute for Immunology Research, Dallas, TX, USA.

The skin is the second most frequently affected organ system in lupus erythematosus. Although only very rarely life threatening--an example is lupus erythematosus-associated toxic epidermal necrolysis--skin disease contributes disproportionally to disease burden in terms of personal and psychosocial wellbeing, vocational disability, and hence in medical and social costs. Since several manifestations are closely associated with the presence and activity of systemic lupus erythematosus, prompt and accurate diagnosis of cutaneous lupus erythematosus is essential. Read More

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http://dx.doi.org/10.1177/0961203310370048DOI Listing
August 2010
49 Reads

A Case of Kikuchi's Disease Presenting with Unique Facial Involvement.

Ann Dermatol 2010 May 18;22(2):196-8. Epub 2010 May 18.

Department of Dermatology, College of Medicine, Korea University, Seoul, Korea.

Kikuchi's disease (KD), or histiocytic necrotizing lymphadenitis, is a rare, self-limited lymphadenopathy, typically in young women, that usually remits spontaneously and does not recur. KD is clinically characterized by cervical lymphadenopathy and a high fever. Extranodal involvement (skin, arthritis, meningitis) rarely occurs. Read More

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http://dx.doi.org/10.5021/ad.2010.22.2.196DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883425PMC
May 2010
22 Reads

Production-scale purification of the recombinant major house dust mite allergen Der f 2 mutant C8/119S.

J Biosci Bioeng 2010 Nov 12;110(5):597-601. Epub 2010 Jun 12.

Biologics Development & Production Department, The Chemo-Sero-Therapeutic Research Institute (Kaketsuken), 1314-1 Kyokushikawabe, Kikuchi, Kumamoto 869-1298, Japan.

A WHO position paper states that allergen immunotherapy is an effective treatment for allergic diseases, and well characterized allergens should be used in immunotherapy. The house dust mite is a major cause of allergic disease. However, the biological activity of the mite extracts currently used cannot be clearly determined, since these extracts contain various impurities. Read More

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http://dx.doi.org/10.1016/j.jbiosc.2010.05.010DOI Listing
November 2010
25 Reads

The cutaneous lesions of Kikuchi's disease: a comprehensive analysis of 16 cases based on the clinicopathologic, immunohistochemical, and immunofluorescence studies with an emphasis on the differential diagnosis.

Hum Pathol 2010 Sep;41(9):1245-54

Department of Pathology, Ajou University School of Medicine, Suwon, 443-721, Korea.

Kikuchi's disease is a self-limited necrotizing lymphadenitis that is characterized by cervical lymphadenopathy and fever. Although it has been reported that some patients with Kikuchi's disease have cutaneous manifestations, the specific skin changes of patients with Kikuchi's disease have not been fully described. We report here on 16 patients of Kikuchi's disease with cutaneous manifestations. Read More

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http://dx.doi.org/10.1016/j.humpath.2010.02.002DOI Listing
September 2010
20 Reads

Pneumonia due to varicella-zoster virus reinfection in a renal transplant recipient.

Transplant Proc 2009 Nov;41(9):3959-61

Department of Surgery, Sendai Shakaihoken Hospital, Sendai, Japan.

Varicella pneumonia is one of the serious complications of primary varicella zoster virus (VZV) infection in adults. A 36-year-old woman with end-stage renal disease underwent renal transplantation from a living donor in 1998, receiving immunosuppressive treatment with cyclosporine, mycophenolate mofetil, and methylprednisolone. She had a history of VZV infection during childhood. Read More

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http://linkinghub.elsevier.com/retrieve/pii/S004113450901332
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http://dx.doi.org/10.1016/j.transproceed.2009.06.195DOI Listing
November 2009
6 Reads

Augmented cerebral activation by lumbar mechanical stimulus in chronic low back pain patients: an FMRI study.

Spine (Phila Pa 1976) 2009 Oct;34(22):2431-6

Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima city, Fukushima, Japan.

Study Design: Cerebral activation by lumbar mechanical stimulus was investigated by functional magnetic resonance imaging in healthy subjects and patients with chronic low back pain (LBP).

Objectives: To characterize the cerebral substrates of LBP, and to explore a possible pathologic pattern of cerebral activation in chronic LBP patients.

Summary Of Background Data: The cerebral substrates of LBP have been poorly defined in contrast to those of cutaneous somatic pain. Read More

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http://pdfs.journals.lww.com/spinejournal/2009/10150/Augment
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http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:land
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http://dx.doi.org/10.1097/BRS.0b013e3181b1fb76DOI Listing
October 2009
32 Reads

Histologic features of cutaneous lupus erythematosus.

Autoimmun Rev 2009 May 20;8(6):467-73. Epub 2009 Jan 20.

Department of Dermatology, Medical University of Innsbruck, Innsbruck, Austria.

Histologic examination of lesions plays a key role in the diagnostics of cutaneous lupus erythematosus (LE). LE has a broad spectrum of histopathological signs, which are related to the stages of the lesions. In addition to the main subtypes of LE, we report on special manifestations like Rowell's-syndrome and Chilblain LE, and give an account of Kikuchi-Fujimoto disease (histiocytic necrotizing lymphadenitis), which may be associated with systemic LE. Read More

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http://dx.doi.org/10.1016/j.autrev.2008.12.014DOI Listing
May 2009
12 Reads

Interface dermatitis in skin lesions of Kikuchi-Fujimoto's disease: a histopathological marker of evolution into systemic lupus erythematosus?

Lupus 2008 Dec;17(12):1127-35

Department of Dermatology, Hospital Juan Canalejo, La Coruña, Spain.

Kikuchi's disease (KD) is a self-limiting histiocytic necrotizing lymphadenitis (HNL). Cutaneous manifestations are frequent and usually show histopathological findings similar to those observed in the involved lymph nodes. HNL with superposed histological features to KD has been described in patients with lupus erythematosus (LE), and a group of healthy patients previously reported as having HNL may evolve into LE after several months. Read More

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http://dx.doi.org/10.1177/0961203308092161DOI Listing
December 2008
7 Reads

Case of Sweet's syndrome with extensive necrosis and ulcers accompanied by myelodysplastic syndrome.

J Nippon Med Sch 2008 Jun;75(3):162-5

Department of Cutaneous and Mucosal Pathophysiology, Graduate School of Medicine, Nippon Medical School, Sendagi, Bunkyo-ku, Tokyo, Japan.

A 43-year-old woman presented with a persistent high fever of 39 degrees C and edematous erythema accompanied by pustules on the face, trunk and extremities. Conjunctivitis and nodules were also observed in the right eye. On the basis of the clinical symptoms and histopathological findings. Read More

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http://dx.doi.org/10.1272/jnms.75.162DOI Listing
June 2008
9 Reads

Kikuchi's disease: case report and systematic review of cutaneous and histopathologic presentations.

J Am Acad Dermatol 2008 Jul 7;59(1):130-6. Epub 2008 May 7.

Department of Dermatology, University of Wisconsin Hospitals and Clinics, Madison, Wisconsin 53715, USA.

Kikuchi's disease, also known as histiocytic necrotizing lymphadenitis, is a systemic illness with classic clinical findings of cervical lymphadenopathy and fever. Diagnosis is confirmed by lymph node histology, which reveals paracortical foci of necrosis and a histiocytic infiltrate. Kikuchi's disease has been associated with a number of infections, but no single source has been identified. Read More

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http://dx.doi.org/10.1016/j.jaad.2008.03.012DOI Listing
July 2008
6 Reads

[Pfeifer-Weber-Christian syndrome associated with Kikuchi syndrome in infliximab therapy: development of necrotizing allergic vasculitis].

Hautarzt 2007 Dec;58(12):1018, 1020-1

Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein der Technischen Universität München, Biedersteiner Strasse 29, 80802, München, Germany.

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http://dx.doi.org/10.1007/s00105-007-1426-6DOI Listing
December 2007
3 Reads

Examination of percutaneous application in a 26-week carcinogenicity test in CB6F1-TG rasH2 mice.

J Toxicol Sci 2007 Oct;32(4):367-75

Central Institute for Experimental Animals, Kawasaki, Japan.

We examined the possibility of expanding applications of rasH2 mice, which are genetically manipulated mice for short-term carcinogenicity tests, to percutaneous application. A 26-week short-term carcinogenicity study was performed on a total of 300 mice including 75 male and female rasH2 mice each, and 75 male and female non-Tg mice each from the same litter as the rasH2 mice divided into untreated group, an ethanol group, a white Vaseline group, an acetone group, and a phorbol 12-myristate 13-acetate (TPA) group. Only shaving of dorsal skin was performed on the untreated mice. Read More

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http://dx.doi.org/10.2131/jts.32.367DOI Listing
October 2007
6 Reads

Clinicopathological study of Kikuchi's disease.

Indian J Pathol Microbiol 2007 Jul;50(3):485-8

Department of Pathology, Kasturba Medical College, Mangalore, Karnataka.

Kikuchi's disease (KD) is a necrotizing lymphadenopathy with a self-limiting course commonly affecting young people. We conducted a clinico-pathological study of 20 cases of KD received at our department between July 2000 and December 2003. Our study confirmed that KD commonly involves the cervical lymph nodes of young adults, with a female predominance. Read More

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July 2007
9 Reads

Adverse antibiotic-induced eruptions associated with epstein barr virus infection and showing Kikuchi-Fujimoto disease-like histology.

Am J Dermatopathol 2006 Feb;28(1):48-55

Division of Dermatology, Department of Pathology, Albany Medical College, Albany, New York 12208, USA.

The antibiotic-induced eruption of infectious mononucleosis is a well-known clinical phenomenon. Latent viral infection with herpesviridae (eg, human herpes virus 6 (HHV-6) and Epstein-Barr virus (EBV)) is suspected to play a role in the drug hypersensitivity syndrome. The cutaneous pathologic findings have not been reported in the former, and are infrequently reported in the latter entity. Read More

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https://insights.ovid.com/crossref?an=00000372-200602000-000
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http://dx.doi.org/10.1097/01.dad.0000164604.56650.26DOI Listing
February 2006
7 Reads

Terbinafine-induced subacute cutaneous lupus erythematosus.

Dermatology 2006 ;212(1):59-65

Department of Dermatology 1, Saint Louis Hospital, Paris, France.

Background: Nearly 10% of lupus erythematosus (LE) are drug induced. More than 60 different drugs are involved in iatrogenic LE. We report herein 3 cases of terbinafine-induced LE. Read More

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https://www.karger.com/Article/FullText/89024
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http://dx.doi.org/10.1159/000089024DOI Listing
January 2006
15 Reads