177,714 results match your criteria Cutaneous Horn
Oncol Res Treat 2018 Dec 12;42(1-2). Epub 2018 Dec 12.
Introduction: Breast cancer is responsible for more than 50% of cutaneous metastases. One of the treatment options is electrochemotherapy (ECT). It is an effective method of local tumor ablation through the application of electroporation. Read More
Head Neck 2018 Dec 7. Epub 2018 Dec 7.
Department of Otolaryngology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Background: This study examined the potential use of our newly developed prevascularized oral mucosal cell sheet for the treatment of skin wounds.
Methods: Mucosal cell sheets containing cultured keratinocytes and plasma fibrin without (K sheet) or with a mixture of fibroblasts and endothelial progenitor cells (PV sheet) were transplanted into full-thickness skin excisional wounds of nude mice.
Results: This technique was successful for in vitro culture; expanding keratinocytes, fibroblasts, and endothelial progenitor cells; and generating prevascularized mucosal cell sheets. Read More
J Dtsch Dermatol Ges 2018 Dec;16(12):1459-1476
While epidemic typhus caused by Rickettsia prowazekii posed a significant threat in Europe before and throughout World War II due to its high mortality, the condition fortunately no longer plays a significant role. Nevertheless, rickettsioses, such as African tick bite fever, have been increasingly diagnosed in travelers returning from sub-Saharan Africa. Caused by Rickettsia africae, African tick bite fever presents with characteristic cutaneous findings such as eschar (tache noir) and a rash. Read More
J Dtsch Dermatol Ges 2018 Dec;16(12):1425-1432
Department of Dermatology and Venereology, Innsbruck Medical University, Innsbruck, Austria.
The nomenclature system agreed upon by the Chapel Hill Consensus Conference (CHCC) with respect to the terminology and precise definition of the various types of vasculitis has gained widespread interdisciplinary and international acceptance. As the revised version from 2012 (CHCC 2012) does not address the special features of vasculitis of the skin, it has recently been supplemented with an addendum containing the nomenclature of cutaneous vasculitides (D-CHCC). The present article provides the German translation of the terms and defintions of the D-CHCC as well as additional explanatory comments. Read More
J Dtsch Dermatol Ges 2018 Dec;16(12):1434-1442
Department of Dermatology, Eberhardt Karls University, Tübingen Germany.
Background: Cutaneous sarcomas are rare and characterized by pathogenetic heterogeneity. Knowledge about local infiltration patterns and recurrence rates may be useful in improving patient care and outcomes. The objective of the present study was to compare these two characteristics in sarcomas that had been treated using the identical surgical procedure. Read More
Head Neck 2018 Dec 10. Epub 2018 Dec 10.
Service of Dermatology, Hospital Universitario Central de Asturias, Universidad de Oviedo, Oviedo, Spain.
Background: Focal adhesion kinase (FAK) and cortactin overexpression is frequently detected in a variety of cancers, and has been associated with poor clinical outcome. However, there are no data in cutaneous squamous cell carcinoma (cSCC).
Objective: To investigate the relationship of FAK and cortactin expression with the clinicopathologic features and the impact on the prognosis of cSCC patients. Read More
Contact Dermatitis 2018 Dec 10. Epub 2018 Dec 10.
Department of Cutaneous Allergy, St John's Institute of Dermatology, Guy's & St Thomas' NHS Foundation Trust, London, UK.
There is a lack of published data on the role of patch testing in patients with so-called multiple chemical sensitivity (MCS), also known as idiopathic environmental intolerances (IEI). This disputed chronic condition is characterised by symptoms that the affected person attributes to low-level exposures to commonly used chemicals. Symptoms are typically vague and non-specific and may include fatigue, headaches, nausea, dizziness, a sensation of skin burning or pain. Read More
Int J Dermatol 2018 Dec 10. Epub 2018 Dec 10.
Department of Dermatology, University of Texas Medical School, Houston, TX, USA.
A number of pruritic skin conditions arising in immunocompromised patients are associated with viral infection. Recently, human polyomavirus 7 (HPyV7) has been implicated in the pathogenesis of eruptive pruritic parakeratotic and dyskeratotic dermatoses with distinct "peacock plumage" histology. While expression of HPyV7 viral protein, namely small tumor (sT) antigen, is prominent within lesional tissue, the functional role of HPyV7 in cutaneous pathobiology is not yet known. Read More
Head Neck 2018 Dec 7. Epub 2018 Dec 7.
Department of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, Iowa.
Background: Malignant melanomas on skin graft recipient sites are rare, with few cases reported in the literature.
Methods: We present a case report of a patient with recurrent cutaneous melanoma in the grafted anterolateral thigh flap of the tongue.
Results: A patient underwent hemiglossectomy with free flap reconstruction for squamous cell carcinoma of the tongue. Read More
Br J Dermatol 2018 Dec 7. Epub 2018 Dec 7.
Instituto de Investigación Hospital 12 de Octubre, Universidad Complutense de Madrid, Madrid, Spain.
Background: Reprogramming of energy metabolism to enhanced aerobic glycolysis has been defined as a hallmark of cancer.
Objective: To investigate the role of the mitochondrial proteins, β-subunit of the H -ATP synthase (β-F1-ATPase), and heat-shock protein 60 (HSP60), and the glycolytic markers, glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and pyruvate kinase M2 (PKM2), as well as the bioenergetic cellular (BEC) index, in melanoma progression.
Material And Methods: The expression of energy metabolism proteins were assessed on a set of different melanoma cells representing the natural biological history of the disease: primary cultures of melanocytes, radial (WM35) and vertical (WM278) growth phases, and poorly (C81-61-PA) and highly (C8161-HA) aggressive melanoma cells. Read More
J Cell Physiol 2018 Dec 7. Epub 2018 Dec 7.
Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Objectives: Impaired wound healing and skin dehydration are the mainstay of systemic sclerosis (SSc) cutaneous manifestations. Aquaporin-3 (AQP3) has a pivotal role in skin hydration and wound healing. Epidermal growth factor receptor (EGFR) activation is impaired in SSc fibroblasts. Read More
J Dermatol 2018 Dec 7. Epub 2018 Dec 7.
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Histiocytoses, including Langerhans cell histiocytosis (LCH), juvenile or adult xanthogranuloma (AXG) and Rosai-Dorfman disease (RDD), are rare disorders characterized by the proliferation of cells derived from monocyte/macrophage lineages. A few cases of LCH coexisting with xanthogranuloma or RDD have been reported. The etiology of these diseases remains unclear. Read More
Am J Hematol 2018 Dec 8. Epub 2018 Dec 8.
Division of Hematology, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Overview: Systemic mastocytosis (SM) results from a clonal proliferation of abnormal mast cells (MC) in extra-cutaneous organs.
Diagnosis: The major criterion is presence of multifocal clusters of abnormal MC in the bone marrow. Minor diagnostic criteria include elevated serum tryptase level, abnormal MC CD25 expression, and presence of KITD816V mutation. Read More
Head Neck 2018 Dec 7. Epub 2018 Dec 7.
Department of Otolaryngology, Head & Neck Surgery, Monash Health, Melbourne, Australia.
Current management of metastatic cutaneous squamous cell carcinoma (CSCC) to the parotid is surgical excision and postoperative radiotherapy. In the node-negative neck, there is debate about the role of elective neck dissection (END), irradiation or observation. This systematic review assesses the prevalence of occult cervical disease and the evidence for END. Read More
Pediatr Int 2018 Nov;60(11):1036-1037
Department of Pediatric Cardiology, Okinawa Children's Medical Center, Okinawa, Japan.
Adv Ther 2018 Dec 7. Epub 2018 Dec 7.
Amgen Ltd, Uxbridge, UK.
Introduction: Talimogene laherparepvec is a first-in-class oncolytic immunotherapy for intratumoral injection with proven efficacy and tolerability in patients with unresectable early metastatic melanoma (stage IIIB-IVM1a) in the pivotal phase III OPTiM study. The objective was to characterize melanoma patients treated with talimogene laherparepvec in routine clinical practice in Germany.
Methods: A retrospective chart review was conducted in unresectable stage IIIB-IVM1a melanoma patients. Read More
Rev Chilena Infectol 2018 Aug;35(4):445-447
Escuela de Medicina Humana, Universidad Científica del Sur, Lima, Perú.
Infection with Strongyloides stercoralis is a common parasitic infection in tropical and subtropical regions, including the Peruvian Amazon. The clinical manifestations are varied in patients with immunocompromised disease, and the systemic spread of the disease is frequent, compromising different organs and systems. Cutaneous manifestations are infrequent, being described in patients with some degree of immunosuppression. Read More
Rev Chilena Infectol 2018 ;35(3):266-275
Departamento de Dermatología, Pontificia Universidad Católica de Chile, Santiago, Chile.
Background: Loxoscelism is a common pathology in our environment with a broad spectrum of differential diagnoses and presentations, with potentially serious complications, even to the point of death. To date, there is no standard treatment for these patients.
Aim: To describe the clinical manifestations, main complications, therapeutic management, and evolution of loxoscelism in an inpatient setting from a tertiary hospital in Chile. Read More
Rom J Morphol Embryol 2018 ;59(3):977-983
Department of Plastic Surgery, "Grigore T. Popa" University of Medicine and Pharmacy, Iaşi, Romania;
Basal cell carcinoma (BCC) is the most common type of cancer located in the periocular area. We will present the clinical case of a 63-year-old male patient who was admitted to the 2nd Clinic of Neurosurgery, "Prof. Dr. Read More
Rom J Morphol Embryol 2018 ;59(3):949-953
"Victor Babeş" National Institute for Research and Development in Pathology and Biomedical Sciences, Bucharest, Romania;
Ionizing radiation was used in the past for treatment of several benign cutaneous conditions, and particularly hemangiomas. Even though radiotherapy was generally effective, it significantly augmented the risk for malignancies, resulting in a consequent heavy decline of its use for benign conditions. However, radiation-induced neoplasia is still encountered in adult patients irradiated during childhood or adolescence. Read More
Plast Reconstr Surg Glob Open 2018 Oct 3;6(10):e1953. Epub 2018 Oct 3.
Department of Pediatric Surgery, Meyer Children Hospital, Florence, Italy.
Ecthyma Gangrenosum is a manifestation of infection, usually occurring in immunocompromised patients, which can be associated with bacteremia with potentially lethal outcome. The clinical appearance is of an inflammatory cutaneous lesion with a central necrotic spot; the lesion then rapidly progresses to a gangrenous ulcer with a gray-black eschar extending in the deep soft tissues. Treatment of Ecthyma Gangrenosum includes both aggressive systemic antibiotic therapy and surgical procedures. Read More
Plast Reconstr Surg Glob Open 2018 Oct 2;6(10):e1927. Epub 2018 Oct 2.
Section of Plastic Surgery, Department of Surgery, University of Calgary, Calgary, Alberta.
Mucormycosis is a rare fungal infection caused by ubiquitous fungi in the order Mucorales. It is the most rapidly progressing fulminant fungal infection that mimics necrotizing soft-tissue infections. Overwhelming fungal sepsis develops quickly and mortality rates approach 70%. Read More
Plast Reconstr Surg Glob Open 2018 Oct 15;6(10):e1908. Epub 2018 Oct 15.
Department of Plastic and Reconstructive Surgery, Kansai Medical University, Osaka, Japan.
For medial canthal tendon reattachment, many kinds of surgical technique have previously been reported. They are complicated and generally require technical skill and prolonged operating times. We, for the first time, describe a novel device, the Caraji Anchor Suture System, used for reattaching the medial canthal tendon to the medial orbital wall after removal of squamous cell carcinoma. Read More
Int J Sports Phys Ther 2018 Dec;13(6):993-1007
Niederrhein University of Applied Sciences, Faculty of Health Care, Therapeutic Sciences, Reinarzstr. 49, 47805 Krefeld, Germany.
Background: Ankle sprains frequently result in persistent sensorimotor deficits. Sufficient evidence of effects of sensorimotor training using unstable devices on physical functions is lacking. There is no insight as to whether simultaneous tactile stimulation of plantar foot mechanoreceptors using textured surfaces may influence outcomes in people with a history of ankle sprain. Read More
J Inflamm (Lond) 2018 4;15:25. Epub 2018 Dec 4.
1Department of Forensic Pathology, China Medical University School of Forensic Medicine, No.77, Puhe Road, Shenyang North New Area, Shenyang, 110122 Liaoning Province People's Republic of China.
Background: The anti-inflammatory properties of the cannabinoid 2 receptor (CB2R) in injury and inflammatory diseases have been widely substantiated. Specifically, the anti-inflammatory effect of CB2R may be achieved by regulating macrophage polarisation. Several research findings suggested that the activation of CB2R could attenuate inflammation by reducing pro-inflammatory M1 macrophage polarisation and promoting anti-inflammatory M2 polarisation. Read More
J Cutan Aesthet Surg 2018 Jul-Sep;11(3):150-152
AboutSkin Dermatology and DermSurgery, Denver, Colorado, USA.
Background And Objective: Reconstructing the contours of the auricle is a unique challenge. Various bolster techniques have been tried to help prevent complications such as hematoma, seroma, and morbidity. Here, we describe a simple technique using a button to maintain the natural ear contour when it is at risk of a poor aesthetic outcome. Read More
Microbiol Resour Announc 2018 Oct 25;7(16). Epub 2018 Oct 25.
Guangdong Key Laboratory of Animal Conservation and Resource Utilization, Guangdong Public Laboratory of Wild Animal Conservation and Utilization, Guangdong Institute of Applied Biological Resources, Guangzhou, China.
Austwickia chelonae, a species of Actinobacteria, is one of the pathogens that cause dermatophilosis in animals. Here, we report the complete genome sequence of Austwickia chelonae LK16-18, which was isolated from cutaneous granulomas in crocodile lizards. Read More
JAAD Case Rep 2019 Jan 27;5(1):1-4. Epub 2018 Nov 27.
Dermatology Department, University Hospital of Bordeaux, Bordeaux, France.
Med Mycol Case Rep 2019 Mar 25;23:31-33. Epub 2018 Oct 25.
Laboratorio de Micologia y Fitopatologia (LAMFU), Departamento de Ciencias Biológicas, Facultad de ciencias, Universidad de los Andes, Bogota 111711, Colombia.
Chromoblastomycosis is a chronic cutaneous and subcutaneous mycosis, is caused by dematiaceous fungi, the most frequently implicated are and We report a woman who was treated before with mycological cure, but she experience a relapse requiring treatment again. Direct microscopic examination and skin biopsy with culture were necessary to identify a Exophiala psychrophila, and for our knowledge this is the first case reported. Read More
Case Rep Rheumatol 2018 4;2018:4216938. Epub 2018 Nov 4.
Department of Orthopedic Surgery, Tokyo Women's Medical University, Tokyo, Japan.
Psoriatic arthritis (PsA) is a type of inflammatory arthritis characterized by cutaneous psoriasis, peripheral joint damage, axial joint damage, and enthesitis and is usually diagnosed after the appearance of psoriatic skin disease. PsA mutilans is relatively rare in Japan. In the present case, the patient was diagnosed with PsA with foot mutilans deformity only. Read More
Gac Med Mex 2018 ;154(Supp 2):S36-S40
Presidente de Dermatología Comunitaria México, Subdirección de Enseñanza e Investigación. México.
Introduction: Community dermatology (CD) is integrated by dermatologists, epidemiologists and interested people. It has 27 years of experience at the Guerrero State. Due to unsafety issues, the teaching and medical attention model had to be changed from presential to virtual trough telemedicine. Read More
Gac Med Mex 2018 ;154(Supp 2):S41-S49
Unidad de Fototerapia. Hospital General Dr. Manuel Gea González, Ciudad de México, México.
Introduction: T-cell lymphoid dyscrasia is a group of different, infrequent, epitheliotropic inflammatory dermatosis that precede cutaneous T-cell lymphomas. Treatment with ultraviolet radiation is safe and efficacious.
Objective: To describe responses to treatment, secondary effects and complications. Read More
Gac Med Mex 2018 ;154(6):712-715
Instituto Mexicano del Seguro Social, Centro Médico Nacional Siglo XXI, Hospital de Oncología, Ciudad de México, México.
Most patients with cutaneous melanoma present with clinical stage 1 at diagnosis, i.e., with no evidence of lymph node or systemic metastases. Read More
Nature 2018 Dec 10. Epub 2018 Dec 10.
Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
Animals and humans display two types of response to noxious stimuli. The first includes reflexive defensive responses that prevent or limit injury; a well-known example of these responses is the quick withdrawal of one's hand upon touching a hot object. When the first-line response fails to prevent tissue damage (for example, a finger is burnt), the resulting pain invokes a second-line coping response-such as licking the injured area to soothe suffering. Read More
Plast Reconstr Surg 2018 Nov 26. Epub 2018 Nov 26.
Si-Zheng Zhou, Wen-Jin Wang and Shuang-Bai Zhou contributed equally to this work and should be considered co-first authors.
Background: Current rodent models of wound healing and scarring are flawed due to rapid wound contraction and inconspicuous scarring after healing, which is not closely parallel to the physiological process in human. This study was designed to establish a novel model of wound healing and scarring in rats.
Methods: Excisional wounds were generated in rat tail or dorsal skin and assessed in terms of histological changes and wound contraction 2, 10 and 16 days postinjury. Read More
Am J Dermatopathol 2018 Nov 27. Epub 2018 Nov 27.
Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, PA.
Am J Dermatopathol 2018 Nov 27. Epub 2018 Nov 27.
Unidad de Investigación Médica en Inmunoquímica, Hospital de Especialidades, Centro Médico Nacional SXXI, IMSS, Mexico City, México.
The role of Mycobacterium tuberculosis in the etiology and pathogenesis of cutaneous tuberculosis is controversial because of the difficulties associated with demonstrating the presence of these mycobacteria in tuberculid cutaneous lesions by routinely available microbiological and histological techniques. In this study, we aimed to demonstrate the presence of M. tuberculosis in cutaneous tuberculosis. Read More
Am J Dermatopathol 2018 Nov 22. Epub 2018 Nov 22.
Department of Pathology, University of Washington School of Medicine, Seattle, WA.
Palisaded encapsulated neuromas (PENs) are benign cutaneous nerve sheath proliferations that typically occur as flesh-colored papules solitarily on the head and neck in adults, with a slight predilection for females. Histopathologically, they are partially or completely encapsulated intradermal nodules with Schwann cells and axons in fascicles separated by clefts. Although these features are often characteristic, the hypercellular variant of PEN can pose a diagnostic challenge in distinguishing between other cellular neural and melanocytic lesions. Read More
Ann Plast Surg 2019 Jan;82(1):104-109
Division of Plastic Surgery, University of Kentucky, Lexington, KY.
Purpose: Postmastectomy radiation therapy is an important component of the multimodality approach to later-stage breast cancers. Unfortunately, despite its proven survival benefits, postmastectomy radiation therapy is deleterious to the skin and soft tissue, causing increased complications and worse aesthetic outcomes after breast reconstruction.There is currently no effective pharmaceutical agent to mitigate the soft tissue fibrosis and hypovascularity associated with soft tissue radiation. Read More
Appl Immunohistochem Mol Morphol 2018 Dec 7. Epub 2018 Dec 7.
Section of Dermatopathology, Division of Surgical Pathology-Cytopathology, University of Virginia Medical Center, Charlottesville, VA.
Basaloid tumors of the skin pose a diagnostic challenge to pathologists, because the differential diagnosis is broad, sometimes with subtle differentiating features. We evaluated SOX10 expression in 120 primary cutaneous tumors with epidermal, sweat glandular, neuroendocrine/neuroectodermal, follicular, and sebaceous lineages. Our findings were compared with those of previous studies that evaluated SOX10 in tumors of the skin. Read More
J Investig Med 2018 Dec 6. Epub 2018 Dec 6.
Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Henoch-Schönlein purpura (HSP) is a common autoimmune vasculitis in childhood. The detailed pathogenesis of HSP is still unclear, whereas several types of predisposing factors have been proved to be the initial step. The objectives of present study were to analyze the distribution of predisposing factors, association of the predisposing factors with clinical manifestations and HSP relapse/recurrence. Read More
Eur J Dermatol 2018 Oct;28(5):597-605
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, 4200-135 Porto, Portugal, Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup) - Cancer Signaling and Metabolism, Rua Dr. Roberto Frias, s/n, 4200-465 Porto, Portugal, Medical Faculty, University of Porto, Al. Prof. Hernâni Monteiro, 4200 Porto, Portugal, Department of Pathology, Medical Faculty of Porto University, Porto, Portugal.
In this review, the current knowledge of cutaneous squamous cell carcinogenesis (cSCC) is outlined based on an appraisal of the different features of cSCC, with particular emphasis on genetic alterations underlying aetiopathogenesis. When appropriate, diagnostic and/or prognostic biomarkers for cSCC are also considered. This review is intended to aid future investigation into the molecular characterization of cSCC. Read More
Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.
University Hospital of Tours, Department of Dermatology, Unit of Pediatric Dermatology, Center of Reference of Cutaneous Vascular Malformations (MAGEC), Tours, France.
Eur J Dermatol 2018 Dec 10. Epub 2018 Dec 10.
University of Pavia, Dermatologic Clinic, IRCCS Policlinico San Matteo, Pavia, Italy.
J Am Acad Dermatol 2018 Dec 6. Epub 2018 Dec 6.
Chief and profesor for dermatology department; Place where work was done: Universidad Autonoma de Nuevo León, Facultad de Medicina, Hospital Universitario ''Dr. José E. González'' Servicio de Dermatología, Monterrey, NL, México. Electronic address:
Acta Trop 2018 Dec 7. Epub 2018 Dec 7.
Université Côte d'Azur, Inserm, C3M, Nice Cedex 3, France. Electronic address:
Given the prevalence of cancer and leishmaniasis worldwide, the presence of these two pathologies in the same tissue sample may be merely fortuitous. The clinical outcome of both diseases is under the control of innate and adaptive immunity, and in both cases these progressive diseases are characterized by an impaired host Th1 response. As a consequence, the Th2 cytokine microenvironment occurring in progressive leishmaniasis may potentially promote tumor cell proliferation and vice versa. Read More
Burns 2018 Dec 7. Epub 2018 Dec 7.
Department of Paediatrics Otolaryngology Head & Neck Surgery, Princess Margaret Hospital for Children, Roberts Road, Subiaco, Western Australia 6008, Australia; Murdoch ENT, Wexford Medical Centre, St John of God Hospital (Murdoch), Suite 17-18, Level 1, 3 Barry Marshall Parade, Murdoch, Western Australia 6150, Australia; School of Surgery, University of Western Australia, Stirling Highway, Crawley, Perth, Western Australia 6009, Australia; St John of God Hospital (Murdoch), Wexford Medical Center, Suite 17-18, Level 1, 3 Barry Marshall Parade, Murdoch 6150, Western Australia, Australia.
Objective: To review and discuss the existing research on the pathophysiology, impact and management of inhalational injury on the larynx and lower respiratory tract.
Data Sources: A literature search was conducted on the PubMed, MedLine, Embase, Web of Science and Google Scholar databases based on the keywords "airway burn", "inhalational injury" and "larynx".
Review Methods: Inclusion criteria included English language studies containing original and review data on airway injury. Read More
Neoplasia 2018 Dec 4;21(1):82-92. Epub 2018 Dec 4.
Department of Dermatology, University of Wisconsin and the Middleton VA Medical Center, Madison, WI. Electronic address:
Advanced-stage cutaneous T-cell lymphoma (CTCL) is usually a fatal malignancy despite optimal use of currently available treatments. In this preclinical study of novel CTCL therapy, we performed in vitro and ex vivo experiments to determine the efficacy of combination treatment with a panel of BET bromodomain inhibitors (BETi) (JQ1, OTX015, CPI-0610, I-BET762) and HDAC inhibitors (HDACi) (SAHA/Vorinostat, Romidepsin). BETi/HDACi combinations were synergistic (combination index <1) against cell viability and induced G0/G1 cell cycle arrest. Read More
J Allergy Clin Immunol Pract 2018 Dec 6. Epub 2018 Dec 6.
Division of Dermatology, Department of Medicine, University of Cape Town, Cape Town, South Africa; Combined Drug Allergy Clinic, Groote, Schuur Hospital, Cape Town, South Africa. Electronic address:
J Allergy Clin Immunol Pract 2018 Dec 6. Epub 2018 Dec 6.
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea; Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul National University College of Medicine, Seoul, Korea; Regional Pharmacovigilance Center, Seoul National University Hospital, Seoul, Korea. Electronic address:
Background: Although HLA-B*58:01 is a well-known risk factor for the development of allopurinol-induced severe cutaneous adverse reactions (SCARs), most of the HLA-B*58:01 carriers do not suffer from SCARs despite a long-term use of allopurinol. This suggests that there are other risk factors that determine the fate of HLA-B*58:01 carriers.
Objective: The aim of this study was to investigate the additional genetic factors that increases the risk of allopurinol-induced SCARs in HLA-B*58:01 carriers. Read More