1,378 results match your criteria Cutaneous Horn


[Cutaneous horns: Clinical presentation of skin tumours].

Semergen 2022 May 16. Epub 2022 May 16.

Medicina Familiar y Comunitária, Centro de Salud Mar Báltico, Madrid, España.

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Perspectives on Use of the Cutaneous Direct Immunofluorescence Assay-Reply.

JAMA Dermatol 2022 May 11. Epub 2022 May 11.

MGPO Dermatopathology Associates, Newton, Massachusetts.

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Cutaneous horn over penis: A rare case report.

J Cutan Aesthet Surg 2021 Oct-Dec;14(4):454-455

Department of Pathology, IMS & SUM Hospital, Bhubaneswar, India.

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A rare case report of graft-versus-host disease-related cutaneous horns of the lower lip.

JAAD Case Rep 2022 Mar 8;21:59-62. Epub 2022 Jan 8.

Department of Oral and Maxillofacial Surgery, Hospital of Oost-Limburg, Schiepse Bos 6, Genk, Belgium.

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A syngeneic inoculation mouse model of endometriosis that develops multiple comorbid visceral and cutaneous pain like behaviours.

Pain 2021 Dec 15. Epub 2021 Dec 15.

Visceral Pain Research Group, College of Medicine and Public Health, Flinders Health and Medical Research Institute (FHMRI), Flinders University, Bedford Park, South Australia, Australia Hopwood Centre for Neurobiology, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia Discipline of Medicine, University of Adelaide, Adelaide, South Australia, Australia.

Abstract: Endometriosis is a chronic and debilitating condition, commonly characterised by chronic pelvic pain (CPP) and infertility. Chronic pelvic pain can be experienced across multiple pelvic organs, with comorbidities commonly effecting the bowel, bladder, and vagina. Despite research efforts into endometriosis pathophysiology, little is known about how endometriosis induces CPP, and as such, therapeutic interventions are lacking. Read More

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December 2021

Giant Cutaneous Horn (Cornu Cutaneum) Developing from a Hypertrophic Burn Scar.

Adv Skin Wound Care 2022 Feb;35(2):125-127

Nur Cihan Cosansu, MD, is Dermatologist, Sakarya University, Education and Research Hospital, Department of Dermatology, Sakarya, Turkey. Tuba Cetiner, MD, is Dermatologist, Izmit Seka State Hospital, Department of Dermatology, Kocaeli, Turkey. Gülcan Yuksekal, MD, is Dermatologist, Yenikent State Hospital, Department of Dermatology, Sakarya, Turkey. The authors have disclosed no financial relationships related to this article. Submitted January 2, 2021; accepted in revised form March 12, 2021.

Abstract: A cornu cutaneum (CC) is a rare lesion. This case report describes a 63-year-old woman with a giant CC lesion on her right hip arising from a hypertrophic burn scar at its base. To the authors' knowledge, this is the first case described in the literature of a CC that developed from a burn scar. Read More

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February 2022

Efficacy of cryotherapy in the treatment of cutaneous horn associated with papillomatosis in a dog.

Vet Dermatol 2022 Jun 18;33(3):243-246. Epub 2022 Jan 18.

Department of Veterinary Medicine and Surgery, Veterinary Institute, Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropédica, Brazil.

Cutaneous horn is a skin disease with low incidence and few citations in the literature. This report describes a dog with multiple cutaneous lesions of papillomatosis and one giant cutaneous horn on the face. Two sessions of cryotherapy achieved complete remission of the lesions. Read More

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Discrete field potentials produced by coherent activation of spinal dorsal horn neurons.

Exp Brain Res 2022 Feb 10;240(2):665-686. Epub 2022 Jan 10.

Department of Physiology, Biophysics and Neurosciences, Center for Research and Advanced Studies, National Polytechnic Institute, Ciudad de México, México.

In addition to the action potentials generated by the ongoing activation of single dorsal horn neurons in the anesthetized cat, we often recorded small negative field potentials with a fast-rising phase and a slow decay (dIFPs). These potentials could be separated in different classes, each with a specific and rather constant shape and amplitude. They were largest in spinal laminae III-V and gradually faded at deeper locations, without showing the polarity reversal displayed at these depths by the focal potentials produced by stimulation of muscle and cutaneous afferents. Read More

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February 2022

Cutaneous Horn Revisited: A Woman With a Verruca Vulgaris-Associated Cornu Cutaneum.

Cureus 2021 Nov 26;13(11):e19925. Epub 2021 Nov 26.

Dermatology, University of California Davis Medical Center, Sacramento, USA.

A cutaneous horn, sometimes referred to as cornu cutaneum, is a projection arising on the skin due to an overgrowth of the epidermal stratum corneum. This lesion is a clinical presentation of an underlying skin tumor. A woman with a verruca vulgaris-associated cutaneous horn is described. Read More

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November 2021

Spinal integration of hot and cold nociceptive stimuli by wide-dynamic-range neurons in anesthetized adult rats.

Pain Rep 2021 Nov-Dec;6(4):e983. Epub 2021 Dec 16.

Centre National de la Recherche Scientifique, University of Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, Strasbourg, France.

Introduction: Early neuronal processing of thermal noxious information relies mostly on molecular detectors of the transient receptor potential family expressed by specific subpopulation of sensory neurons. This information may converge to second-order wide-dynamic-range (WDR) neurons located in the deep layer of the dorsal horn of the spinal cord.

Method: Using a micro-Peltier thermode thermal contact stimulator II delivering various cold and hot noxious stimulations, we have characterized the extracellular electrophysiological responses of mechanosensitive WDR neurons in anesthetized adult male and female Wistar rats. Read More

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December 2021

Cutaneous horn on the penile shaft.

Indian J Sex Transm Dis AIDS 2021 Jul-Dec;42(2):177-178. Epub 2021 Jul 27.

Department of Dermatology, Venereology and Leprosy, GMC, Kota, Rajasthan, India.

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Recalcitrant Warts, Epidermodysplasia Verruciformis, and the Tree-Man Syndrome: Phenotypic Spectrum of Cutaneous Human Papillomavirus Infections at the Intersection of Genetic Variability of Viral and Human Genomes.

J Invest Dermatol 2022 May 27;142(5):1265-1269. Epub 2021 Nov 27.

Department of Dermatology & Cutaneous Biology, Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA; Jefferson Institute of Molecular Medicine, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Electronic address:

Human papillomavirus (HPV) infections can cause common warts, which usually resolve spontaneously or become recalcitrant, resistant to multiple treatments. In rare cases, they transform into cutaneous giant horns resulting in the tree-man syndrome (TMS). Defective β-HPVs can cause flat warts in epidermodysplasia verruciformis (EV), a genetic disorder. Read More

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Papillary eccrine adenoma presenting as a cutaneous horn.

Int J Dermatol 2021 Oct 30. Epub 2021 Oct 30.

Department of Dermatology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt.

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October 2021

Assessment of Clinical and Laboratory Use of the Cutaneous Direct Immunofluorescence Assay.

JAMA Dermatol 2021 Nov;157(11):1343-1348

Massachusetts General Physician Organization Dermatopathology Associates, Newton, Massachusetts.

Importance: Dermatologists submit direct immunofluorescence (DIF) biopsies on a daily basis, using an assay detecting immunoreactant deposition with a panel that has traditionally comprised immunoglobulin (Ig) G, IgA, IgM, C3, and fibrin, with or without albumin antibodies.

Objectives: To evaluate and compare the frequency of immunoreactants in DIF biopsies submitted over an 8-year period and assess use by dermatologists based on clinical impression.

Design, Setting, And Participants: A quality improvement study was conducted in a community outreach reference laboratory associated with a large academic medical center. Read More

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November 2021

From the inside out: oculocerebrocutaneous syndrome without dermatological manifestations.

Childs Nerv Syst 2021 Sep 29. Epub 2021 Sep 29.

Department of Radiology, Hospital de Clínicas da Universidade Federal Do Paraná, Curitiba, Paraná, Brazil.

Delleman-Oorthuys or oculocerebrocutaneous syndrome (OCCS) is an extremely rare condition which relies on three pillars of manifestations: ophthalmological, neurological, and dermatological. It was first described by Delleman and Oorthuys in 1981, and since then, very few other cases have been reported. We report the case of a 13-month-old boy, referred to an ophthalmological tertiary service for investigation of a microglobe with a cystic retrobulbar mass on translucency test. Read More

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September 2021

Cutaneous Horn Overlying Inverted Follicular Keratosis: A Rare Case Report.

Indian Dermatol Online J 2021 Jul-Aug;12(4):636-638. Epub 2021 Jun 20.

Belle'Skin Care and Laser Clinic, Ahilyadevi Holkar Marg, Near Tupsakhare Lawns, Mumbai Naka, Nashik, Maharashtra, India.

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Cutaneous Horn on Four-year-old Child's Arm: A Quiz.

Acta Derm Venereol 2021 Oct 12;101(10):adv00567. Epub 2021 Oct 12.

Department of Dermatology, CHU Tours, FR-37000 Tours, France.

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October 2021

Substances for regenerative wound healing during antler renewal stimulated scar-less restoration of rat cutaneous wounds.

Cell Tissue Res 2021 Oct 14;386(1):99-116. Epub 2021 Aug 14.

Institute of Antler Science and Product Technology, Changchun Sci-Tech University, Changchun, Jilin, 130600, China.

Scarification is the outcome of cutaneous wound healing under normal conditions. Although considerable effort has been expended in this field, scar-less healing has not been achieved satisfactorily. The lack of a good model of scar-free healing has contributed to this undesirable situation. Read More

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October 2021

Cutaneous involvement in anti-HMGCR positive necrotizing myopathy.

J Autoimmun 2021 09 28;123:102691. Epub 2021 Jul 28.

Department of Rheumatology and Immunology, University Hospital and, University of Bern, CH-3010, Bern, Switzerland; Medical Center Monbijou (MZM), CH-3011, Bern, Switzerland. Electronic address:

Objective: Anti-3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) positive immune-mediated necrotizing myopathy (IMNM) is a rare disease. It is induced by exogenous substances, most often by statins. Little is known about cutaneous manifestations of HMGCR positive IMNM and about HMGCR antibody positivity in other diseases. Read More

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September 2021

Angiosarcoma of the Face: A Case Study and Literature Review of Local and Metastatic Angiosarcoma.

Case Rep Oncol Med 2021 1;2021:8823585. Epub 2021 Jul 1.

Drexel Hematology/Oncology, 230 N Broad St, Philadelphia PA, USA.

Angiosarcomas are vascular malignancies with a tendency to spread extensively both locally and systemically. We report a case of cutaneous angiosarcoma of the face in a 53-year-old man that was originally misdiagnosed as an abscess. Initially small, the lesion enlarged over a four-to-six-month period and began to bleed. Read More

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Piezo2 mechanosensitive ion channel is located to sensory neurons and nonneuronal cells in rat peripheral sensory pathway: implications in pain.

Pain 2021 11;162(11):2750-2768

Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI, United States.

Abstract: Piezo2 mechanotransduction channel is a crucial mediator of sensory neurons for sensing and transducing touch, vibration, and proprioception. We here characterized Piezo2 expression and cell specificity in rat peripheral sensory pathway using a validated Piezo2 antibody. Immunohistochemistry using this antibody revealed Piezo2 expression in pan primary sensory neurons of dorsal root ganglia in naïve rats, which was actively transported along afferent axons to both central presynaptic terminals innervating the spinal dorsal horn (DH) and peripheral afferent terminals in the skin. Read More

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November 2021

Cutaneous horn of the lower eyelid: A hyperkeratotic tear!

J Fr Ophtalmol 2021 Oct 15;44(8):1286-1287. Epub 2021 Jul 15.

Ophthalmology department, Rabat Mohammed V University, Morocco.

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October 2021

Squamous cell carcinoma during long term hydroxyurea treatment: A case report.

Int J Surg Case Rep 2021 Aug 30;85:106160. Epub 2021 Jun 30.

Department of Stomatology, Oral and Maxillofacial Surgery, Hospital of August 20th, University Hospital, Casablanca, Morocco; Faculty of Medicine and Pharmacy, Hassan 2 University of Casablanca, Casablanca, Morocco.

Background: Hydroxyurea (HU) is a ribonucleotide diphosphate reductase inhibitor that interferes with the S phase of cell replication and inhibits DNA synthesis, with limited or no effect on RNA or protein synthesis. The cutaneous side effects of hydroxyurea treatment are diverse and frequent. Squamous cell carcinoma is one of the most challenging side-effect. Read More

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Cutaneous Horn of the Glans.

Case Rep Dermatol 2021 May-Aug;13(2):304-309. Epub 2021 Jun 17.

Sector of Dermatology and Post Graduation Course in Dermatology, University Hospital and School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.

Cutaneous horn is a protuberance constituted by compact keratinous material, with a hard consistence similar to a horn, which occurs more frequently in photoexposed areas. The authors describe a case of cutaneous horn on the glans considered a rare location. Verrucous carcinoma was the histopathological diagnosis of the base of the horn and lichen sclerosis, the precursor lesion. Read More

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Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy.

Cell 2021 07 1;184(14):3812-3828.e30. Epub 2021 Jul 1.

Zahedan University of Medical Sciences, 054 Zahedan, Iran.

We study a patient with the human papilloma virus (HPV)-2-driven "tree-man" phenotype and two relatives with unusually severe HPV4-driven warts. The giant horns form an HPV-2-driven multifocal benign epithelial tumor overexpressing viral oncogenes in the epidermis basal layer. The patients are unexpectedly homozygous for a private CD28 variant. Read More

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Extensive Facial Trichoblastoma - A Rare and Disfiguring Condition.

Am J Case Rep 2021 Jun 25;22:e932320. Epub 2021 Jun 25.

Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, Selangor, Malaysia.

BACKGROUND Trichoblastoma is a rare, benign, cutaneous adnexal neoplasm arising from rudimentary hair follicles. The incidence and prevalence in the general population is unknown. However, most cases occur in adults aged 40 years and older. Read More

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Responses of cutaneous C-fiber afferents and spinal microglia after hindlimb cast immobilization in rats.

J Physiol Sci 2021 Jun 23;71(1):19. Epub 2021 Jun 23.

Department of Physical Therapy, Faculty of Rehabilitation, Niigata University of Health and Welfare, 1398 Shimami-cho, Kita-ku, Niigata, 950-3198, Japan.

Previous studies have shown that persistent limb immobilization using a cast increases nociceptive behavior to somatic stimuli in rats. However, the peripheral neural mechanisms of nociception remain unclear. Using single-fiber electrophysiological recordings in vitro, we examined the general characteristics of cutaneous C-fiber afferents in the saphenous nerve and their responsiveness to mechanical and heat stimuli in a rat model of immobilization-induced pain by subjecting the rats to hindlimb cast immobilization for 4 weeks. Read More

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MrgprdCre lineage neurons mediate optogenetic allodynia through an emergent polysynaptic circuit.

Pain 2021 07;162(7):2120-2131

Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, United States.

Abstract: Most cutaneous C fibers, including both peptidergic and nonpeptidergic subtypes, are presumed to be nociceptors and respond to noxious input in a graded manner. However, mechanically sensitive, nonpeptidergic C fibers also respond to mechanical input in the innocuous range, so the degree to which they contribute to nociception remains unclear. To address this gap, we investigated the function of nonpeptidergic afferents using the MrgprdCre allele. Read More

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Clinical characteristics and therapy response in unresectable melanoma patients stage IIIB-IIID with in-transit and satellite metastases.

Eur J Cancer 2021 07 5;152:139-154. Epub 2021 Jun 5.

Dept. of Dermatology, University Hospital Essen, University of Duisburg-Essen, Hufelandstr. 55, 45122, Essen, Germany; German Cancer Consortium (DKTK), Heidelberg, Germany.

Introduction: Cutaneous melanoma is notorious for the development of in-transit metastases (ITM). For unknown biological reasons, ITM remain the leading tumour manifestation without progression to distant sites in some patients.

Methods: In total, 191 patients with initially unresectable stage III ITM and satellite metastases from 16 skin cancer centres were retrospectively evaluated for their tumour characteristics, survival and therapy response. Read More

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Facial cutaneous horn in three different conditions: A highlight of a malignancy risk.

Int J Surg Case Rep 2021 Jun 21;83:105999. Epub 2021 May 21.

Faculty of Medicine and Pharmacy, Hassan II University of Casablanca, Casablanca, Morocco; Oral and maxillofacial surgery department, CHU Ibn Rochd, Casablanca, Morocco.

Introduction: Cutaneous horns are nodules composed of compact keratin that project above the surface of the skin. The purpose of this work is to show the danger that can constitute the cutaneous horns.

Presentation Of Cases: In this paper, the authors report series of three cases of facial cutaneous horns, which were respectively diagnosed as trichilemmal horn in a 79-years old patient, a cutaneous horn underlying epidermoid carcinoma in a 59-years old patient, and a basal cell carcinoma in an 80-years old patient. Read More

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