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    1229 results match your criteria Cutaneous Horn

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    Claw foot A case report.
    Ann Ital Chir 2017 Jun 8;6. Epub 2017 Jun 8.
    A cutaneous horn could be defined as a conical projection on the surface of skin made of cornified material and resembling an animal horn. These lesions most commonly affect light-skinned men aged between 50 to 89 years and usually appear in sun exposed areas. Radiation, chronic irritation and even human papilloma virus-2 infection may be precipitating factors. Read More

    Presynaptic inhibition of nociceptive neurotransmission by somatosensory neuron-secreted suppressors.
    Sci China Life Sci 2017 Jun 15. Epub 2017 Jun 15.
    Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science, Chinese Academy of Sciences, Shanghai, 200031, China.
    Noxious stimuli cause pain by activating cutaneous nociceptors. The Aδ- and C-fibers of dorsal root ganglion (DRG) neurons convey the nociceptive signals to the laminae I-II of spinal cord. In the dorsal horn of spinal cord, the excitatory afferent synaptic transmission is regulated by the inhibitory neurotransmitter γ-aminobutyric acid and modulators such as opioid peptides released from the spinal interneurons, and by serotonin, norepinepherine and dopamine from the descending inhibitory system. Read More

    Keratoacanthoma of the Nasal Septum Secondary to Ranibizumab Use.
    Case Rep Pathol 2017 11;2017:8257590. Epub 2017 May 11.
    Department of Otolaryngology-Head and Neck Surgery, Crozer-Chester Medical Center, One Medical Center Boulevard, Upland, PA, USA.
    Keratoacanthoma (KA) is a benign epithelial tumor that typically presents as a firm, cone-shaped, flesh-colored nodule with a central horn-filled crater. KA is considered to be a low-grade variant of squamous cell carcinoma (SCC). We report a rare case of a 72-year-old male who presented with a KA involving the nasal septum, possibly related to ranibizumab use. Read More

    Conditioned pain modulation dampens the thermal grill illusion.
    Eur J Pain 2017 Jun 2. Epub 2017 Jun 2.
    Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, USA.
    Background: The thermal grill illusion (TGI) refers to the perception of burning heat and often pain that arises from simultaneous cutaneous application of innocuous warm and cool stimuli. This study utilized conditioned pain modulation (CPM) to help elucidate the TGI's underlying neural mechanisms, including the debated role of ascending nociceptive signals in generating the illusion.

    Methods: To trigger CPM, subjects placed the left hand in noxious cold (6 °C) water before placing the right volar forearm onto a thermal grill. Read More

    A Giant Cutaneous Horn Projecting from Verrucous Carcinoma of Buccal Mucosa: A Rare Case Report.
    J Clin Diagn Res 2017 Mar 1;11(3):ZD04-ZD05. Epub 2017 Mar 1.
    Reader, Department of Conservative Dentistry and Endodontics, Patna Dental College and Hospital, Patna, Bihar, India.
    Cutaneous horn is conical shape of compact keratin that resembles a miniature animal horn. Though morphologically similar to horns in animals they are histologically very different from them. It is a circumscribed, conical, hyperkeratotic dense protrusion with epithelial cornification above the skin surface in response to a wide range of underlying benign and malignant pathological changes. Read More

    Successful Excision of Cutaneous Horns in the Foot and Application of a Full-Thickness Pinch Skin Graft for Primary Closure.
    J Am Podiatr Med Assoc 2017 Mar;107(2):158-161
    Cutaneous horns (cornu cutaneum) are chronic, dense, hyperkeratotic cutaneous lesions resembling the horn of an animal. These lesions are associated with a variety of benign, premalignant, and malignant cutaneous diseases. Cutaneous horns are often found on the upper parts of the body, such as the face, neck, and shoulders. Read More

    Targeted next generation sequencing of mucosal melanomas identifies frequent NF1 and RAS mutations.
    Oncotarget 2017 Jun;8(25):40683-40692
    Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK), University of Duisburg-Essen, Duisburg/Essen, Germany.
    Purpose: Mucosal melanoma represents ~1% of all melanomas, frequently having a poor prognosis due to diagnosis at a late stage of disease. Mucosal melanoma differs from cutaneous melanoma not only in terms of poorer clinical outcome but also on the molecular level having e.g. Read More

    Cutaneous Horn Arising From a Burn Scar: A Case Report and Review of Literature.
    J Burn Care Res 2017 Mar 31. Epub 2017 Mar 31.
    From the *College of Medicine, Mosul University, Mosul, Iraq; and †Al-Jumhoori Teaching Hospital, Mosul, Iraq.
    We report a 36-year-old male presenting with a cutaneous horn from the anterior aspect of left knee burn scar. Cutaneous horn is a cone-shaped, hyperkeratotic lesion. It is seen in sun-exposed areas. Read More

    Peripheral and central anatomical organization of cutaneous afferent subtypes in a rat nociceptive intersegmental spinal reflex.
    J Comp Neurol 2017 Jun 29;525(9):2216-2234. Epub 2017 Mar 29.
    Departments of Neurology and Physiology, Emory University School of Medicine, Atlanta, Georgia.
    Stimulation of rat segmental dorsal cutaneous nerves (DCNs) evokes the nociceptive intersegmental cutaneus trunci muscle (CTM) reflex. The reflex consists of early and late responses, mediated by Aδ and C fibers, respectively, based on required stimulation strengths, and shows segmental differences in terms of amplitude and duration. We have now investigated whether the peripheral or central anatomy of nociceptive afferent subtypes in different DCNs also vary in a segmental manner. Read More

    Trichoadenoma of Nikolowski- A Rare Tumour with Unusual Presentation Over Vulva.
    J Clin Diagn Res 2017 Jan 1;11(1):ED05-ED06. Epub 2017 Jan 1.
    Associate Professor, Department of Pathology, Shaheed Hasan Khan Mewati, Government Medical College , Nalhar, Nuh, Haryana, India .
    Trichoadenoma is a rare benign, slowly growing, cutaneous tumour of the hair follicle first described by Nikolowski in 1958. It presents as a non-specific nodule over the face or buttocks. However, unusual sites such as the neck, upper arm, thigh, shoulder, and shaft of the penis may also be affected. Read More

    Slow brushing reduces heat pain in humans.
    Eur J Pain 2017 Aug 6;21(7):1173-1185. Epub 2017 Mar 6.
    Institute of Neuroscience and Physiology, University of Gothenburg, Sweden.
    Background: C-tactile (CT) afferents are unmyelinated low-threshold mechanoreceptors optimized for signalling affective, gentle touch. In three separate psychophysical experiments, we examined the contribution of CT afferents to pain modulation.

    Methods: In total, 44 healthy volunteers experienced heat pain and CT optimal (slow brushing) and CT sub-optimal (fast brushing or vibration) stimuli. Read More

    Functional Organization of Cutaneous and Muscle Afferent Synapses onto Immature Spinal Lamina I Projection Neurons.
    J Neurosci 2017 Feb 9;37(6):1505-1517. Epub 2017 Jan 9.
    Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267
    It is well established that sensory afferents innervating muscle are more effective at inducing hyperexcitability within spinal cord circuits compared with skin afferents, which likely contributes to the higher prevalence of chronic musculoskeletal pain compared with pain of cutaneous origin. However, the mechanisms underlying these differences in central nociceptive signaling remain incompletely understood, as nothing is known about how superficial dorsal horn neurons process sensory input from muscle versus skin at the synaptic level. Using a novel ex vivo spinal cord preparation, here we identify the functional organization of muscle and cutaneous afferent synapses onto immature rat lamina I spino-parabrachial neurons, which serve as a major source of nociceptive transmission to the brain. Read More

    The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn.
    Neuroscience 2017 Mar 3;344:157-166. Epub 2017 Jan 3.
    Université Clermont Auvergne, Inserm Neuro-Dol U1107, F-63000 Clermont-Ferrand, France; CHU Clermont-Ferrand, Service d'Odontologie, F-63100 Clermont-Ferrand, France. Electronic address:
    Nitric oxide donors are known to produce headache in healthy as well as migraine subjects, and to induce extracephalic cutaneous hypersensitivity in rodents. However, little is known on the effect of nitric oxide donors on cephalic cutaneous sensitivity. Combining behavioral, immunohistochemical, and in vivo electrophysiological approaches, this study investigated the effect of systemic administration of the nitric oxide donor, isosorbide dinitrate (ISDN), on cephalic and extracephalic cutaneous sensitivity and on neuronal activation within the medullary dorsal horn (MDH) in the rat. Read More

    TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity.
    Cell Rep 2016 Dec;17(11):2901-2912
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address:
    Peripheral nerve injury and tissue inflammation result in upregulation of the deubiquitinase USP5, thus causing a dysregulation of T-type calcium channel activity and increased pain sensitivity. Here, we have explored the role of afferent fiber activity in this process. Conditioning stimulation of optogenetically targeted cutaneous TRPV1 expressing nociceptors, but not that of non-nociceptive fibers, resulted in enhanced expression of USP5 in mouse dorsal root ganglia and spinal dorsal horn, along with decreased withdrawal thresholds for thermal and mechanical stimuli that abated after 24 hr. Read More

    Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia: electrophysiological and behavioral assessments.
    J Physiol Sci 2017 May 28;67(3):431-438. Epub 2016 Nov 28.
    Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, 444-8787, Japan.
    We investigated the spinal action of noradrenaline on cold-elicited hyperexcitation detected in dorsal horn neurons of rats with allodynia induced by an oxaliplatin (6 mg/kg, i.p.) injection. Read More

    Spinal cord thermosensitivity: An afferent phenomenon?
    Temperature (Austin) 2016 Apr-Jun;3(2):232-239. Epub 2016 Feb 26.
    Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
    We review the evidence for thermoregulatory temperature sensors in the mammalian spinal cord and reach the following conclusions. 1) Spinal cord temperature contributes physiologically to temperature regulation. 2) Parallel anterolateral ascending pathways transmit signals from spinal cooling and spinal warming: they overlap with the respective axon pathways of the dorsal horn neurons that are driven by peripheral cold- and warm-sensitive afferents. Read More

    Cutaneous Horn of the Eyelid in 13 Cases.
    Ophthal Plast Reconstr Surg 2017 Jul/Aug;33(4):233-236
    *Ocular Oncology Service and †Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
    Introduction: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid.

    Objective: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. Read More

    Safety and efficacy of anti-PD-1 in patients with baseline cardiac, renal, or hepatic dysfunction.
    J Immunother Cancer 2016 18;4:60. Epub 2016 Oct 18.
    Departments of Medicine, Vanderbilt Ingram Cancer Center, 777 PRB, 2220 Pierce Ave., Nashville, TN 37232 USA.
    Background: Anti-PD-1 therapy is increasingly used in various advanced malignancies. Patients with baseline organ dysfunction are largely excluded from clinical trials. Therefore it is unclear whether anti-PD-1 therapy is safe or effective in this setting. Read More

    Panfolliculoma with an endophytic architecture resembling a hair follicle: a report of three cases.
    J Cutan Pathol 2016 Nov 9;43(11):1074-1076. Epub 2016 Sep 9.
    The Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, NY, USA.
    Panfolliculoma is a benign follicular tumor comprised of all components of the hair follicle. We report three cases of panfolliculoma with a solid, endophytic architecture, which at scanning magnification had the profile of a hair follicle. The epithelial components included uniform dark blue germinative cells, matrical cells, clear cells and cells containing trichohyaline granules. Read More

    Novel Cutaneous Manifestations of Pleuroparenchymal Fibroelastosis.
    Am J Dermatopathol 2016 Oct;38(10):e140-3
    *Big Horn Basin Skin Center, Cody, WY; †Department of Dermatology, Cockerell Dermatopathology, UT Southwestern, Dallas, TX; ‡Penrose-St Francis Hospital, Colorado Springs, CO; and §Department of Dermatology, Cockerell Dermatopathology, UT Southwestern, Dallas, TX.
    Pleuroparenchymal fibroelastosis (PPFE) is a rare progressive disease that manifests as parenchymal fibrosis of the upper lobe and pleura. Approximately 100 cases have been reported. Cutaneous manifestations of PPFE have not previously been described. Read More

    Phase 3 evaluation of HP802-247 in the treatment of chronic venous leg ulcers.
    Wound Repair Regen 2016 09 26;24(5):894-903. Epub 2016 Sep 26.
    Smith & Nephew, Inc, Fort Worth, Texas.
    In 2012 we reported promising results from a phase 2 clinical trial of HP802-247, a novel spray-applied investigational treatment for chronic venous leg ulcers consisting of human, allogeneic fibroblasts and keratinocytes. We now describe phase 3 clinical testing of HP802-247, its failure to detect efficacy, and subsequent investigation into the root causes of the failure. Two randomized, controlled trials enrolled a total of 673 adult outpatients at 96 centers in North America and Europe. Read More

    Hymenoptera stings in the head region induce impressive, but not severe sting reactions.
    Allergy 2016 Nov 15;71(11):1632-1634. Epub 2016 Jul 15.
    Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria.
    Stings in the head region are considered to be a risk factor for severe systemic reactions to hymenoptera stings. We supposed that stings in skin areas, which are well supplied with blood, lead to more severe reactions and tested our hypothesis in 847 patients with confirmed hymenoptera venom allergy. However, symptom severity was independent from sting site: only 16. Read More

    Lamina specific postnatal development of PKCγ interneurons within the rat medullary dorsal horn.
    Dev Neurobiol 2017 Jan 30;77(1):102-119. Epub 2016 Jun 30.
    Neuro-Dol, Clermont Université, Université D'Auvergne, BP 10448, F-63000, Clermont-Ferrand & Inserm U1107, Clermont-Ferrand, F-63100, France.
    Protein kinase C gamma (PKCγ) interneurons, located in the superficial spinal (SDH) and medullary dorsal horns (MDH), have been shown to play a critical role in cutaneous mechanical hypersensitivity. However, a thorough characterization of their development in the MDH is lacking. Here, it is shown that the number of PKCγ-ir interneurons changes from postnatal day 3 (P3) to P60 (adult) and such developmental changes differ according to laminae. Read More

    Hypothesis: Hughlings Jackson and presynaptic inhibition: is there a big picture?
    J Neurophysiol 2016 Jul 27;116(1):41-50. Epub 2016 Apr 27.
    McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    Presynaptic inhibition is a very powerful inhibitory mechanism and, despite many detailed studies, its purpose is still only partially understood. One accepted function is that, by reducing afferent inflow to the spinal cord and brainstem, the tonic level of presynaptic inhibition prevents sensory systems from being overloaded. A corollary of this function is that much of the incoming sensory data from peripheral receptors must be redundant, and this conclusion is reinforced by observations on patients with sensory neuropathies or congenital obstetric palsy in whom normal sensation may be preserved despite loss of sensory fibers. Read More

    Imaging large-scale cellular activity in spinal cord of freely behaving mice.
    Nat Commun 2016 Apr 28;7:11450. Epub 2016 Apr 28.
    Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
    Sensory information from mechanoreceptors and nociceptors in the skin plays key roles in adaptive and protective motor behaviours. To date, very little is known about how this information is encoded by spinal cord cell types and their activity patterns, particularly under freely behaving conditions. To enable stable measurement of neuronal and glial cell activity in behaving mice, we have developed fluorescence imaging approaches based on two- and miniaturized one-photon microscopy. Read More

    Pyogenic granuloma underlying cutaneous horn in a young boy.
    Indian Dermatol Online J 2016 Mar-Apr;7(2):114-6
    Department of Dermatology and Venereology, Pramukhswami Medical College, Gujarat, India.
    Cutaneous horn is an elongated, keratinous projection that usually occurs over the sun-exposed areas. It is a clinical diagnosis and may overlie any benign, premalignant, or malignant conditions. Treatment includes wide surgical excision with careful histological examination to exclude a focus of malignancy. Read More

    Solitary Angiokeratoma Presenting as Cutaneous Horn over the Prepuce: A Rare Appearance.
    Indian J Dermatol 2016 Mar-Apr;61(2):236
    Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
    We present a case of a 47-year-old man with 4 months history of conical growth on the prepuce with a progressive increase in size. The patient had been treated for seminoma a decade ago. Histopathology of the growth showed features of angiokeratoma. Read More

    Spinal nociceptive transmission by mechanical stimulation of bone marrow.
    Mol Pain 2016 1;12. Epub 2016 Mar 1.
    Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
    Background: Since bone marrow receives innervation from A-delta and C-fibers and since an increase in intramedullary pressure in bone marrow may induce acute pain in orthopedic patients during surgery and chronic pain in patients with bone marrow edema, skeletal pain may partly originate from bone marrow. Intraosseous lesions, such as osteomyelitis and bone cancer, are also known to produce cutaneous hypersensitivity, which might be referred pain from bone. However, little is known about pain perception in bone marrow and referred pain induced by bone disease. Read More

    Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma.
    J Cutan Pathol 2016 May 6;43(5):422-9. Epub 2016 Apr 6.
    Dermatopathology Unit, Massachusetts General Hospital, Boston, MA, USA.
    Background: Cutaneous lymphadenoma (CL) is rare neoplasm that clinically and histologically resembles basal cell carcinoma (BCC). CL, composed of dermal basaloid epithelial islands with prominent admixed lymphocytes, characteristically contains cytokeratin 20 (CK20)-positive Merkel cells (MCs). However, CK20 may be of limited use because of low MC density in small samples. Read More

    Giant Ocular Horn Occurring in a 10-Year-Old Female.
    Ophthal Plast Reconstr Surg 2017 May/Jun;33(3S Suppl 1):S52-S54
    *Neuro-ophthalmology, Oculoplastics and Orbital Surgery, University of Southwestern Texas Medical Center, Dallas, Texas; †Oculoplastics and Orbital Surgery Service, ‡Pediatric Ophthalmology and Ocular Genetics Service, and §Department of Pathology, Wills Eye Hospital, Philadelphia, PA.
    Cutaneous horns uncommonly involve the periocular region. Involvement of the ocular surface is particularly rare. The authors present a patient who underwent a perinatal buccal mucosal graft for corneal perforation due to congenital corneal ectasia, most likely resulting from Peters anomaly. Read More

    Volar Central Portal in Wrist Arthroscopy.
    J Wrist Surg 2016 Mar 15;5(1):80-90. Epub 2016 Jan 15.
    Department of Human Anatomy and Embryology, School of Medicine, Complutense University of Madrid, Madrid, Spain.
    Background Nowadays, the wrist is not limited to a dorsal visualization; the joint can be thought of as a "box," which can be visualized from almost every perspective. The purpose of this study was to describe a new volar central portal for the wrist, following three principles: a single incision that allows access to both the radiocarpal and midcarpal joints, centered on the lunate, with the volar structures at risk protected not only by retractors, but also by tendons. Description of Technique The incision begins in the distal wrist crease and extended 1. Read More

    A rapidly growing giant cutaneous horn on the chest.
    J Dermatol Case Rep 2015 Dec 31;9(4):113-5. Epub 2015 Dec 31.
    Department of Dermatology, Davao Doctors Hospital, Davao City, Philippines;
    Background: A giant cutaneous horn (GCH) is a morphologic description of conical lesion with a dense, hyperkeratotic protrusion of more than 1 cm in height that resembles an animal horn but without its bony core. These can occur in association with benign, premalignant or malignant cutaneous diseases which can be determined by excision and histopathologic review of the base. A PubMed search (performed June 2015) revealed 54 cases of giant cutaneous horns in world literature. Read More

    Nonparalytic botulinum molecules for the control of pain.
    Pain 2016 May;157(5):1045-55
    aCell and Developmental Biology, University College London, London, United KingdombLaboratory of Neurophysiology of Integrative Autonomic System, Headache Sci. Ctr., "C. Mondino" Natl. Neurological Inst, Pavia, ItalycSchool of Medicine, Pharmacy and Health., Durham Univ., Stockton-on-Tees, United KingdomdDepartment of Brain and Behavior, University of Pavia, Pavia, ItalyeSchool of Life Science, University of Lincoln, Lincoln, United KingdomfDepartment of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
    Local injections of botulinum toxins have been reported to be useful not only for the treatment of peripheral neuropathic pain and migraine but also to cause long-lasting muscle paralysis, a potentially serious side effect. Recently, a botulinum A-based molecule ("BiTox") has been synthesized that retains neuronal silencing capacity without triggering muscle paralysis. In this study, we examined whether BiTox delivered peripherally was able to reduce or prevent the increased nociceptive sensitivity found in animal models of inflammatory, surgical, and neuropathic pain. Read More

    Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system.
    J Neurooncol 2016 May 7;127(3):435-44. Epub 2016 Jan 7.
    Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK) University of Duisburg-Essen, Duisburg-Essen, Germany.
    Melanocytic tumors originating in the central nervous system (MT-CNS) are rare tumors that generally have a favorable prognosis, however malignant tumors do occur. Pathogenetically MT-CNS are not well characterized. Similar to uveal melanoma and blue nevi, they frequently harbor activating GNAQ or GNA11 mutations. Read More

    Multiple Sebaceous Horn on the Penis-an Interesting Case Report.
    Indian J Surg 2015 Dec 30;77(Suppl 2):724-5. Epub 2013 Jan 30.
    Sree Balaji Medical College and Hospital, Chennai, 600044 India.
    Sebaceous horns (de la Pena Zarzuelo et al., Arch Esp Urol 54:367-368, 2001; Vera-Donoso, Scand J Urol Nephrol 43:92-93, 2009) are rare on the penis, as they are commonly seen only on sun-exposed areas. A 45-year-old male presenting with multiple sebaceous horns of the penis is reported here. Read More

    In vivo characterization of colorectal and cutaneous inputs to lumbosacral dorsal horn neurons in the mouse spinal cord.
    Neuroscience 2016 Mar 18;316:13-25. Epub 2015 Dec 18.
    School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia; Hunter Medical Research Institute (HMRI), Rankin Park, NSW, 2287, Australia. Electronic address:
    Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible for ongoing pain are unknown, clinical and preclinical evidence suggests lumbosacral spinal cord dorsal horn neurons contribute to these symptoms. At present, we know little about the intrinsic and synaptic properties of this population of neurons in either normal or inflammed conditions. Read More

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