Search our Database of Scientific Publications and Authors

I’m looking for a

    1213 results match your criteria Cutaneous Horn

    1 OF 25

    Functional Organization of Cutaneous and Muscle Afferent Synapses onto Immature Spinal Lamina I Projection Neurons.
    J Neurosci 2017 Feb 9;37(6):1505-1517. Epub 2017 Jan 9.
    Pain Research Center, Department of Anesthesiology, University of Cincinnati Medical Center, Cincinnati, Ohio 45267
    It is well established that sensory afferents innervating muscle are more effective at inducing hyperexcitability within spinal cord circuits compared with skin afferents, which likely contributes to the higher prevalence of chronic musculoskeletal pain compared with pain of cutaneous origin. However, the mechanisms underlying these differences in central nociceptive signaling remain incompletely understood, as nothing is known about how superficial dorsal horn neurons process sensory input from muscle versus skin at the synaptic level. Using a novel ex vivo spinal cord preparation, here we identify the functional organization of muscle and cutaneous afferent synapses onto immature rat lamina I spino-parabrachial neurons, which serve as a major source of nociceptive transmission to the brain. Read More

    The nitric oxide donor, isosorbide dinitrate, induces a cephalic cutaneous hypersensitivity, associated with sensitization of the medullary dorsal horn.
    Neuroscience 2017 Mar 3;344:157-166. Epub 2017 Jan 3.
    Université Clermont Auvergne, Inserm Neuro-Dol U1107, F-63000 Clermont-Ferrand, France; CHU Clermont-Ferrand, Service d'Odontologie, F-63100 Clermont-Ferrand, France. Electronic address:
    Nitric oxide donors are known to produce headache in healthy as well as migraine subjects, and to induce extracephalic cutaneous hypersensitivity in rodents. However, little is known on the effect of nitric oxide donors on cephalic cutaneous sensitivity. Combining behavioral, immunohistochemical, and in vivo electrophysiological approaches, this study investigated the effect of systemic administration of the nitric oxide donor, isosorbide dinitrate (ISDN), on cephalic and extracephalic cutaneous sensitivity and on neuronal activation within the medullary dorsal horn (MDH) in the rat. Read More

    TRPV1 Nociceptor Activity Initiates USP5/T-type Channel-Mediated Plasticity.
    Cell Rep 2016 Dec;17(11):2901-2912
    Department of Physiology and Pharmacology, Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada. Electronic address:
    Peripheral nerve injury and tissue inflammation result in upregulation of the deubiquitinase USP5, thus causing a dysregulation of T-type calcium channel activity and increased pain sensitivity. Here, we have explored the role of afferent fiber activity in this process. Conditioning stimulation of optogenetically targeted cutaneous TRPV1 expressing nociceptors, but not that of non-nociceptive fibers, resulted in enhanced expression of USP5 in mouse dorsal root ganglia and spinal dorsal horn, along with decreased withdrawal thresholds for thermal and mechanical stimuli that abated after 24 hr. Read More

    Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia: electrophysiological and behavioral assessments.
    J Physiol Sci 2016 Nov 28. Epub 2016 Nov 28.
    Department of Information Physiology, National Institute for Physiological Sciences, Okazaki, 444-8787, Japan.
    We investigated the spinal action of noradrenaline on cold-elicited hyperexcitation detected in dorsal horn neurons of rats with allodynia induced by an oxaliplatin (6 mg/kg, i.p.) injection. Read More

    Spinal cord thermosensitivity: An afferent phenomenon?
    Temperature (Austin) 2016 Apr-Jun;3(2):232-239. Epub 2016 Feb 26.
    Department of Anatomy and Neuroscience, University of Melbourne, Parkville, Victoria, Australia; Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
    We review the evidence for thermoregulatory temperature sensors in the mammalian spinal cord and reach the following conclusions. 1) Spinal cord temperature contributes physiologically to temperature regulation. 2) Parallel anterolateral ascending pathways transmit signals from spinal cooling and spinal warming: they overlap with the respective axon pathways of the dorsal horn neurons that are driven by peripheral cold- and warm-sensitive afferents. Read More

    Cutaneous Horn of the Eyelid in 13 Cases.
    Ophthal Plast Reconstr Surg 2016 Nov 2. Epub 2016 Nov 2.
    *Ocular Oncology Service and †Department of Ophthalmic Pathology, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania, U.S.A.
    Introduction: Cutaneous horn of the eyelid is uncommon. The authors evaluate the features of benign, premalignant, and malignant tumors at the base of cutaneous horn of the eyelid.

    Objective: To describe the clinical and histopathologic features of cutaneous horn of the eyelid. Read More

    Safety and efficacy of anti-PD-1 in patients with baseline cardiac, renal, or hepatic dysfunction.
    J Immunother Cancer 2016 18;4:60. Epub 2016 Oct 18.
    Departments of Medicine, Vanderbilt Ingram Cancer Center, 777 PRB, 2220 Pierce Ave., Nashville, TN 37232 USA.
    Background: Anti-PD-1 therapy is increasingly used in various advanced malignancies. Patients with baseline organ dysfunction are largely excluded from clinical trials. Therefore it is unclear whether anti-PD-1 therapy is safe or effective in this setting. Read More

    Panfolliculoma with an endophytic architecture resembling a hair follicle: a report of three cases.
    J Cutan Pathol 2016 Nov 9;43(11):1074-1076. Epub 2016 Sep 9.
    The Ronald O. Perelman Department of Dermatology, NYU School of Medicine, New York, NY, USA.
    Panfolliculoma is a benign follicular tumor comprised of all components of the hair follicle. We report three cases of panfolliculoma with a solid, endophytic architecture, which at scanning magnification had the profile of a hair follicle. The epithelial components included uniform dark blue germinative cells, matrical cells, clear cells and cells containing trichohyaline granules. Read More

    Novel Cutaneous Manifestations of Pleuroparenchymal Fibroelastosis.
    Am J Dermatopathol 2016 Oct;38(10):e140-3
    *Big Horn Basin Skin Center, Cody, WY; †Department of Dermatology, Cockerell Dermatopathology, UT Southwestern, Dallas, TX; ‡Penrose-St Francis Hospital, Colorado Springs, CO; and §Department of Dermatology, Cockerell Dermatopathology, UT Southwestern, Dallas, TX.
    Pleuroparenchymal fibroelastosis (PPFE) is a rare progressive disease that manifests as parenchymal fibrosis of the upper lobe and pleura. Approximately 100 cases have been reported. Cutaneous manifestations of PPFE have not previously been described. Read More

    Hymenoptera stings in the head region induce impressive, but not severe sting reactions.
    Allergy 2016 Nov 15;71(11):1632-1634. Epub 2016 Jul 15.
    Department of Dermatology and Venerology, Medical University of Graz, Graz, Austria.
    Stings in the head region are considered to be a risk factor for severe systemic reactions to hymenoptera stings. We supposed that stings in skin areas, which are well supplied with blood, lead to more severe reactions and tested our hypothesis in 847 patients with confirmed hymenoptera venom allergy. However, symptom severity was independent from sting site: only 16. Read More

    Lamina specific postnatal development of PKCγ interneurons within the rat medullary dorsal horn.
    Dev Neurobiol 2017 Jan 30;77(1):102-119. Epub 2016 Jun 30.
    Neuro-Dol, Clermont Université, Université D'Auvergne, BP 10448, F-63000, Clermont-Ferrand & Inserm U1107, Clermont-Ferrand, F-63100, France.
    Protein kinase C gamma (PKCγ) interneurons, located in the superficial spinal (SDH) and medullary dorsal horns (MDH), have been shown to play a critical role in cutaneous mechanical hypersensitivity. However, a thorough characterization of their development in the MDH is lacking. Here, it is shown that the number of PKCγ-ir interneurons changes from postnatal day 3 (P3) to P60 (adult) and such developmental changes differ according to laminae. Read More

    Hypothesis: Hughlings Jackson and presynaptic inhibition: is there a big picture?
    J Neurophysiol 2016 Jul 27;116(1):41-50. Epub 2016 Apr 27.
    McMaster University Health Sciences Centre, Hamilton, Ontario, Canada
    Presynaptic inhibition is a very powerful inhibitory mechanism and, despite many detailed studies, its purpose is still only partially understood. One accepted function is that, by reducing afferent inflow to the spinal cord and brainstem, the tonic level of presynaptic inhibition prevents sensory systems from being overloaded. A corollary of this function is that much of the incoming sensory data from peripheral receptors must be redundant, and this conclusion is reinforced by observations on patients with sensory neuropathies or congenital obstetric palsy in whom normal sensation may be preserved despite loss of sensory fibers. Read More

    Imaging large-scale cellular activity in spinal cord of freely behaving mice.
    Nat Commun 2016 Apr 28;7:11450. Epub 2016 Apr 28.
    Waitt Advanced Biophotonics Center, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
    Sensory information from mechanoreceptors and nociceptors in the skin plays key roles in adaptive and protective motor behaviours. To date, very little is known about how this information is encoded by spinal cord cell types and their activity patterns, particularly under freely behaving conditions. To enable stable measurement of neuronal and glial cell activity in behaving mice, we have developed fluorescence imaging approaches based on two- and miniaturized one-photon microscopy. Read More

    Pyogenic granuloma underlying cutaneous horn in a young boy.
    Indian Dermatol Online J 2016 Mar-Apr;7(2):114-6
    Department of Dermatology and Venereology, Pramukhswami Medical College, Gujarat, India.
    Cutaneous horn is an elongated, keratinous projection that usually occurs over the sun-exposed areas. It is a clinical diagnosis and may overlie any benign, premalignant, or malignant conditions. Treatment includes wide surgical excision with careful histological examination to exclude a focus of malignancy. Read More

    Solitary Angiokeratoma Presenting as Cutaneous Horn over the Prepuce: A Rare Appearance.
    Indian J Dermatol 2016 Mar-Apr;61(2):236
    Department of Dermatology, Christian Medical College, Vellore, Tamil Nadu, India.
    We present a case of a 47-year-old man with 4 months history of conical growth on the prepuce with a progressive increase in size. The patient had been treated for seminoma a decade ago. Histopathology of the growth showed features of angiokeratoma. Read More

    Spinal nociceptive transmission by mechanical stimulation of bone marrow.
    Mol Pain 2016 1;12. Epub 2016 Mar 1.
    Department of Anesthesiology and Resuscitology, Shinshu University School of Medicine, Matsumoto, Nagano, Japan.
    Background: Since bone marrow receives innervation from A-delta and C-fibers and since an increase in intramedullary pressure in bone marrow may induce acute pain in orthopedic patients during surgery and chronic pain in patients with bone marrow edema, skeletal pain may partly originate from bone marrow. Intraosseous lesions, such as osteomyelitis and bone cancer, are also known to produce cutaneous hypersensitivity, which might be referred pain from bone. However, little is known about pain perception in bone marrow and referred pain induced by bone disease. Read More

    Cytokeratin 17 is highly sensitive in discriminating cutaneous lymphadenoma (a distinct trichoblastoma variant) from basal cell carcinoma.
    J Cutan Pathol 2016 May 6;43(5):422-9. Epub 2016 Apr 6.
    Dermatopathology Unit, Massachusetts General Hospital, Boston, MA, USA.
    Background: Cutaneous lymphadenoma (CL) is rare neoplasm that clinically and histologically resembles basal cell carcinoma (BCC). CL, composed of dermal basaloid epithelial islands with prominent admixed lymphocytes, characteristically contains cytokeratin 20 (CK20)-positive Merkel cells (MCs). However, CK20 may be of limited use because of low MC density in small samples. Read More

    Giant Ocular Horn Occurring in a 10-Year-Old Female.
    Ophthal Plast Reconstr Surg 2016 Feb 12. Epub 2016 Feb 12.
    *Neuro-ophthalmology, Oculoplastics and Orbital Surgery, University of Southwestern Texas Medical Center, Dallas, Texas; †Oculoplastics and Orbital Surgery Service, ‡Pediatric Ophthalmology and Ocular Genetics Service, and §Department of Pathology, Wills Eye Hospital, Philadelphia, PA.
    Cutaneous horns uncommonly involve the periocular region. Involvement of the ocular surface is particularly rare. The authors present a patient who underwent a perinatal buccal mucosal graft for corneal perforation due to congenital corneal ectasia, most likely resulting from Peters anomaly. Read More

    Volar Central Portal in Wrist Arthroscopy.
    J Wrist Surg 2016 Mar 15;5(1):80-90. Epub 2016 Jan 15.
    Department of Human Anatomy and Embryology, School of Medicine, Complutense University of Madrid, Madrid, Spain.
    Background Nowadays, the wrist is not limited to a dorsal visualization; the joint can be thought of as a "box," which can be visualized from almost every perspective. The purpose of this study was to describe a new volar central portal for the wrist, following three principles: a single incision that allows access to both the radiocarpal and midcarpal joints, centered on the lunate, with the volar structures at risk protected not only by retractors, but also by tendons. Description of Technique The incision begins in the distal wrist crease and extended 1. Read More

    A rapidly growing giant cutaneous horn on the chest.
    J Dermatol Case Rep 2015 Dec 31;9(4):113-5. Epub 2015 Dec 31.
    Department of Dermatology, Davao Doctors Hospital, Davao City, Philippines;
    Background: A giant cutaneous horn (GCH) is a morphologic description of conical lesion with a dense, hyperkeratotic protrusion of more than 1 cm in height that resembles an animal horn but without its bony core. These can occur in association with benign, premalignant or malignant cutaneous diseases which can be determined by excision and histopathologic review of the base. A PubMed search (performed June 2015) revealed 54 cases of giant cutaneous horns in world literature. Read More

    Nonparalytic botulinum molecules for the control of pain.
    Pain 2016 May;157(5):1045-55
    aCell and Developmental Biology, University College London, London, United KingdombLaboratory of Neurophysiology of Integrative Autonomic System, Headache Sci. Ctr., "C. Mondino" Natl. Neurological Inst, Pavia, ItalycSchool of Medicine, Pharmacy and Health., Durham Univ., Stockton-on-Tees, United KingdomdDepartment of Brain and Behavior, University of Pavia, Pavia, ItalyeSchool of Life Science, University of Lincoln, Lincoln, United KingdomfDepartment of Biomedical Science, University of Sheffield, Sheffield, United Kingdom.
    Local injections of botulinum toxins have been reported to be useful not only for the treatment of peripheral neuropathic pain and migraine but also to cause long-lasting muscle paralysis, a potentially serious side effect. Recently, a botulinum A-based molecule ("BiTox") has been synthesized that retains neuronal silencing capacity without triggering muscle paralysis. In this study, we examined whether BiTox delivered peripherally was able to reduce or prevent the increased nociceptive sensitivity found in animal models of inflammatory, surgical, and neuropathic pain. Read More

    Targeted next generation sequencing reveals unique mutation profile of primary melanocytic tumors of the central nervous system.
    J Neurooncol 2016 May 7;127(3):435-44. Epub 2016 Jan 7.
    Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen and the German Cancer Consortium (DKTK) University of Duisburg-Essen, Duisburg-Essen, Germany.
    Melanocytic tumors originating in the central nervous system (MT-CNS) are rare tumors that generally have a favorable prognosis, however malignant tumors do occur. Pathogenetically MT-CNS are not well characterized. Similar to uveal melanoma and blue nevi, they frequently harbor activating GNAQ or GNA11 mutations. Read More

    Multiple Sebaceous Horn on the Penis-an Interesting Case Report.
    Indian J Surg 2015 Dec 30;77(Suppl 2):724-5. Epub 2013 Jan 30.
    Sree Balaji Medical College and Hospital, Chennai, 600044 India.
    Sebaceous horns (de la Pena Zarzuelo et al., Arch Esp Urol 54:367-368, 2001; Vera-Donoso, Scand J Urol Nephrol 43:92-93, 2009) are rare on the penis, as they are commonly seen only on sun-exposed areas. A 45-year-old male presenting with multiple sebaceous horns of the penis is reported here. Read More

    In vivo characterization of colorectal and cutaneous inputs to lumbosacral dorsal horn neurons in the mouse spinal cord.
    Neuroscience 2016 Mar 18;316:13-25. Epub 2015 Dec 18.
    School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW, 2308, Australia; Hunter Medical Research Institute (HMRI), Rankin Park, NSW, 2287, Australia. Electronic address:
    Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible for ongoing pain are unknown, clinical and preclinical evidence suggests lumbosacral spinal cord dorsal horn neurons contribute to these symptoms. At present, we know little about the intrinsic and synaptic properties of this population of neurons in either normal or inflammed conditions. Read More

    Human parasitic protozoan infection to infertility: a systematic review.
    Parasitol Res 2016 Feb 16;115(2):469-77. Epub 2015 Nov 16.
    Department of Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
    Protozoan parasitic diseases are endemic in many countries worldwide, especially in developing countries, where infertility is a major burden. It has been reported that such infections may cause infertility through impairment in male and female reproductive systems. We searched Medline, PubMed, and Scopus databases and Google scholar to identify the potentially relevant studies on protozoan parasitic infections and their implications in human and animal model infertility. Read More

    High-frequency modulation of rat spinal field potentials: effects of slowly conducting muscle vs. skin afferents.
    J Neurophysiol 2016 Feb 11;115(2):692-700. Epub 2015 Nov 11.
    Chair of Neurophysiology, Centre for Biomedicine and Medical Technology (CBTM), Medical Faculty Mannheim, Heidelberg University, Germany; and.
    Long-term potentiation (LTP) in rat spinal dorsal horn neurons was induced by electrical high-frequency stimulation (HFS) of afferent C fibers. LTP is generally assumed to be a key mechanism of spinal sensitization. To determine the contribution of skin and muscle afferents to LTP induction, the sural nerve (SU, pure skin nerve) or the gastrocnemius-soleus nerve (GS, pure muscle nerve) were stimulated individually. Read More

    Penile cutaneous horn: An enigma-newer insights and perspectives.
    Indian J Sex Transm Dis 2015 Jan-Jun;36(1):26-9
    Department of Dermatology and STD, Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Puducherry, India.
    Cutaneous horn refers to unusually cohesive keratinized material and not a true pathologic diagnosis. Though cutaneous horn has been described at various sites, horn over the penis is very rare and represents the most unusual site. The role of chronic irritation, phimosis, surgical trauma and radiotherapy have been implicated in penile horn formation. Read More

    Analysis of SDHD promoter mutations in various types of melanoma.
    Oncotarget 2015 Sep;6(28):25868-82
    Department of Dermatology, University Hospital Essen, University Duisburg-Essen, West German Cancer Center and the German Cancer Consortium (DKTK), Essen Germany.
    Objectives: Recently, recurrent mutations in regulatory DNA regions, such as promoter mutations in the TERT gene were identified in melanoma. Subsequently, Weinhold et al. reported SDHD promoter mutations occurring in 10% of melanomas and being associated with a lower overall survival rate. Read More

    MITF is a critical regulator of the carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in malignant melanoma.
    Pigment Cell Melanoma Res 2015 Nov;28(6):736-40
    Skin Cancer Unit of the Dermatology Department, Medical Faculty, West German Cancer Center, University Duisburg-Essen, Essen, Germany.
    The multifunctional Ig-like carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is neo-expressed in the majority of malignant melanoma lesions. CEACAM1 acts as a driver of tumor cell invasion, and its expression correlates with poor patient prognosis. Despite its importance in melanoma progression, how CEACAM1 expression is regulated is largely unknown. Read More

    Giant Cutaneous Horn Overlying A Verruca at an Uncommon Site: Medical Marvel vs Superstitious Dilemma.
    J Clin Diagn Res 2015 Apr 1;9(4):PD13-4. Epub 2015 Apr 1.
    Post Graduate, Department of General Surgery, Yenepoya Medical College, Yenepoya University , Mangalore, Karnataka, India .
    Cutaneous horn has been a matter of discussion to mankind since time immemorial and a subject of fascination for the layman. There have been instances where certain groups saw it with angst and disgust, with a person having a large cutaneous horn on an exposed area getting a dismal look. We present a case of a 64-year-old man with a giant cutaneous horn over his left gluteal region. Read More

    Primary afferent neurons containing calcitonin gene-related peptide but not substance P in forepaw skin, dorsal root ganglia, and spinal cord of mice.
    J Comp Neurol 2015 Dec 11;523(17):2555-69. Epub 2015 Jun 11.
    Department of Anatomy and Histology, and Centre for Neuroscience, Flinders University, Adelaide, South Australia, 5001, Australia.
    In mice dorsal root ganglia (DRG), some neurons express calcitonin gene-related peptide (CGRP) without substance P (SP; CGRP(+) SP(-) ). The projections and functions of these neurons are unknown. Therefore, we combined in vitro axonal tracing with multiple-labeling immunohistochemistry to neurochemically define these neurons and characterize their peripheral and central projections. Read More

    Cutaneous Penile Horn.
    Urology 2015 Jun 14;85(6):e45. Epub 2015 May 14.
    Division of Urology, Alameda Health System, Oakland, CA.
    A 70-year-old man presented with a slowly enlarging glans penis lesion measuring approximately 3 × 2 × 2 cm. On examination, the lesion was indurated with no induration of the glans penis deep to the lesion. He had no palpable lymphadenopathy. Read More

    Photoletter to the editor: Giant cutaneous horn associated with squamous cell carcinoma.
    J Dermatol Case Rep 2015 Mar 31;9(1):27-8. Epub 2015 Mar 31.
    Department of Dermatology, Venereology and Allergology, University Hospital Würzburg, Germany.
    A 90-year-old patient presented with a large cutaneous horn (cornu cutaneum) of nine-year duration arising at her right cheek. The lesion was removed by surgery. Histology was reported as cornu cutaneum with a well-differentiated squamous cell carcinoma at its base. Read More

    Drug targets of migraine and neuropathy: treatment of hyperexcitability.
    CNS Neurol Disord Drug Targets 2015 ;14(5):664-76
    Department of Neurology, University of Szeged, Semmelweis u. 6, H-6725, Szeged, Hungary.
    Migraine and neuropathic pain are common causes of chronic pain. The exact pathomechanism has not been fully clarified for either disorder, but their pathophysiological backgrounds involve several similar mechanisms. Peripheral sensitization occurs in the neuronal elements of the dorsal root ganglion or the trigeminal ganglion, while central sensitization appears in the second-order neurons in the dorsal horn of the spinal cord or the trigeminal nucleus caudalis. Read More

    Inhibition of temporomandibular joint input to medullary dorsal horn neurons by 5HT3 receptor antagonist in female rats.
    Neuroscience 2015 Jul 23;299:35-44. Epub 2015 Apr 23.
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, United States.
    Repeated forced swim (FS) conditioning enhances nociceptive responses to temporomandibular joint (TMJ) stimulation in female rats. The basis for FS-induced TMJ hyperalgesia remains unclear. To test the hypothesis that serotonin 3 receptor (5HT3R) mechanisms contribute to enhanced TMJ nociception after FS, ovariectomized female rats were treated with estradiol and subjected to FS for three days. Read More

    Spinal cord neuron inputs to the cuneate nucleus that partially survive dorsal column lesions: A pathway that could contribute to recovery after spinal cord injury.
    J Comp Neurol 2015 Oct 2;523(14):2138-60. Epub 2015 Jun 2.
    Department of Psychology, Vanderbilt University, Nashville, Tennessee, 37240, USA.
    Dorsal column lesions at a high cervical level deprive the cuneate nucleus and much of the somatosensory system of its major cutaneous inputs. Over weeks of recovery, much of the hand representations in the contralateral cortex are reactivated. One possibility for such cortical reactivation by hand afferents is that preserved second-order spinal cord neurons reach the cuneate nucleus through pathways that circumvent the dorsal column lesions, contributing to cortical reactivation in an increasingly effective manner over time. Read More

    Electrochemotherapy in advanced skin tumors and cutaneous metastases - a retrospective multicenter analysis.
    J Dtsch Dermatol Ges 2015 Apr;13(4):308-15
    Department of Dermatology, Venereology and Allergology, HELIOS St. Elisabeth Hospital Oberhausen, Germany.
    Background And Objectives: Once classic treatments such as chemotherapy or radiation therapy have been exhausted, only few therapeutic options remain for extensive skin tumors or cutaneous metastases. In such cases, electrochemotherapy may be considered as alternative therapy.

    Patients And Methods: In this retrospective study, clinical features, treatment response, and adverse effects were evaluated in 56 patients treated with electrochemotherapy at six German dermatology departments. Read More

    A huge cutaneous horn of ear.
    Facial Plast Surg 2015 Feb 12;31(1):88-90. Epub 2015 Mar 12.
    Department of Ear, Throat and Nose, Necmettin Erbakan University, School of Medicine, Konya, Turkey.
    A rare case of huge cutaneous horn of the ear was presented. The lesion was totally excised over the auricular cartilage with a 5-mm margin and the defect was closed with a full-thickness skin graft taken from the preauricular area. To the best of our knowledge, there is no any report of this kind of interesting cutaneous corn of the ear. Read More

    Incidental Merkel cell carcinoma in a cutaneous horn: a case report.
    Dermatol Pract Concept 2015 Jan 30;5(1):47-50. Epub 2015 Jan 30.
    Department of Pathology, London Health Sciences Centre and Western University, London, Ontario, Canada.
    Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine malignancy, which usually presents as an asymptomatic, rapidly growing, firm nodule on sun-damaged skin. We present a 93-year-old female who presented with a "cutaneous horn" on the face. On excision, histologic examination revealed a combined squamous cell carcinoma in situ with underlying MCC. Read More

    1 OF 25