1,345 results match your criteria Cutaneous Horn

Cutaneous Horn: A Very Rare Presentation of Nail Unit Squamous Cell Carcinoma.

Dermatol Surg 2021 Apr 19. Epub 2021 Apr 19.

Department of Dermatology and Venereology, Trakya University, Medical Faculty, Edirne, Turkey Department of Medical Pathology, Trakya University, Medical Faculty, Edirne, Turkey Department of Dermatology and Venereology, University of Health Sciences, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.

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Central, but not peripheral, nervous system ERK2 is essential for itch signals in murine allergic skin inflammation.

Allergy 2021 Apr 21. Epub 2021 Apr 21.

Department of Dermatology, National Defense Medical College, Tokorozawa, Japan.

Background: Itch is a common cutaneous symptom in a variety of dermatological diseases, but detailed neuropathological mechanisms remain to be fully elucidated. This study aimed to assess in vivo ERK2 functions in the nervous system for itch responses.

Methods: We generated conditional knockout mice deficient in ERK2 of the central nervous system (CNS) or peripheral nervous system (PNS), respectively, and assessed chemical and mechanical itch responses in vivo. Read More

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The encoding of cutaneous stimuli by lamina I projection neurons.

Pain 2021 Mar 24. Epub 2021 Mar 24.

Neurorestoration group, Wolfson Centre for Age-Related Diseases, King's College London, London, UK Spinal Cord Group, Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK.

Abstract: Lamina I of the dorsal horn, together with its main output pathway, lamina I projection neurons, have long been implicated in the processing of nociceptive stimuli, as well as the development of chronic pain conditions. However, the study of lamina I projection neurons is hampered by technical challenges, including the low throughput and selection biases of traditional electrophysiological techniques. Here we report on a technique which employs anatomical labelling strategies and in vivo imaging to simultaneously study a network of lamina I projection neurons in response to electrical and natural stimuli. Read More

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Cutaneous horn overlying verrucous carcinoma on face and its dermoscopic characterization.

Indian J Dermatol Venereol Leprol 2021 May-Jun;87(3):388-390

Department of Pathology, University College of Medical Sciences and GTB Hospital (University of Delhi), New Delhi, India.

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Factors related to delayed treatment: A case report of a huge cutaneous horn and review of the literature.

Ann Med Surg (Lond) 2020 Dec 10;60:384-388. Epub 2020 Nov 10.

Department of Medical and Surgical Sciences, Division of Plastic Surgery, University of Modena and Reggio Emilia, Policlinico of Modena, Largo Pozzo 71, 41124, Modena, Italy.

We present a case of a man with a giant cutaneous horn over his frontal region. This case has been presented for the size of the lesion, due to delayed treatment, and to illustrate the reasons why the growth of this lesion has been possible in a western country, in the 21st century. It was a solitary, not painful lesion which caused significant aesthetic problems. Read More

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December 2020

A Functional Topographic Map for Spinal Sensorimotor Reflexes.

Neuron 2021 01 11;109(1):91-104.e5. Epub 2020 Nov 11.

Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address:

Cutaneous somatosensory modalities play pivotal roles in generating a wide range of sensorimotor behaviors, including protective and corrective reflexes that dynamically adapt ongoing movement and posture. How interneurons (INs) in the dorsal horn encode these modalities and transform them into stimulus-appropriate motor behaviors is not known. Here, we use an intersectional genetic approach to functionally assess the contribution that eight classes of dorsal excitatory INs make to sensorimotor reflex responses. Read More

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January 2021

Histological and Immunohistochemical Features of Trichoblastoma in a Sarda Breed Sheep.

Animals (Basel) 2020 Nov 4;10(11). Epub 2020 Nov 4.

Department of Veterinary Medicine, University of Sassari, 07100 Sassari, Italy.

Skin tumors with adnexal differentiation are commonly reported in dogs and cats, while only anecdotal evidence is available in sheep. Here we illustrate the macroscopic, histologic, and immunohistochemical features of a cutaneous lesion with adnexal differentiation in a 6-year-old female Sarda breed sheep, surgically treated for a horn-like mass located in the left pinna. Additionally, we investigate a possible contribution of Ovine Papillomaviruses (OaPVs). Read More

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November 2020

A Curious Case of Cutaneous Horn.

Cureus 2020 Sep 5;12(9):e10253. Epub 2020 Sep 5.

Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND.

Cutaneous horns are uncommon lesions that occur as conical projections in various sun-exposed parts of the body. They are made of hyperkeratotic material and look similar to animal horns. These lesions lack a central bony core that differentiates them from the animal horns. Read More

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September 2020

Medical illustration in China: Lam Qua and his Western-style paintings.

Jessica S Yang

Clin Dermatol 2020 Jul - Aug;38(4):489-493. Epub 2020 Apr 16.

Rowan University School of Osteopathic Medicine, Stratford, New Jersey, USA. Electronic address:

Lam Qua, a Chinese artist who painted in the Western style, was hired by American ophthalmologist and missionary Peter Parker to paint Parker's Chinese patients. Most of Lam Qua's paintings depict patients with rather large tumors located in various areas across the body; there are a few that are also of dermatologic interest. This contribution explores Lam Qua's paintings that depict a cutaneous horn, gangrenous necrosis, and an ulcerating tumor. Read More

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October 2020

Correction to: Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia.

J Neural Transm (Vienna) 2020 Sep 22. Epub 2020 Sep 22.

Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.

The original version of this article unfortunately contained a mistake. Read More

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September 2020

Secondary Involvement of the Uterine Cervix by Nongynecologic Neoplasms: A Detailed Clinicopathologic Analysis.

Am J Surg Pathol 2020 12;44(12):1699-1711

Institute of Pathology, University Hospital of Leipzig, Germany.

Secondary involvement of the uterine cervix by nongynecologic neoplasms is rare accounting for <2% of metastases to the gynecologic tract. This study aimed to analyze the clinicopathologic features of cervical involvement by nongynecologic malignancies. A total of 47 cases were identified including 39 (83%) carcinomas, 6 lymphomas (12. Read More

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December 2020

Low-Threshold Mechanosensitive VGLUT3-Lineage Sensory Neurons Mediate Spinal Inhibition of Itch by Touch.

J Neurosci 2020 09 7;40(40):7688-7701. Epub 2020 Sep 7.

Dr. Phillip Frost Department of Dermatology & Cutaneous Surgery and Miami Itch Center, University of Miami Miller School of Medicine, Miami, Florida 33136

Innocuous mechanical stimuli, such as rubbing or stroking the skin, relieve itch through the activation of low-threshold mechanoreceptors. However, the mechanisms behind this inhibition remain unknown. We presently investigated whether stroking the skin reduces the responses of superficial dorsal horn neurons to pruritogens in male C57BL/6J mice. Read More

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September 2020

Involvement of astrocytes activation in orofacial hyperalgesia induced by experimental tooth movement.

Orthod Craniofac Res 2021 Feb 14;24(1):147-154. Epub 2020 Sep 14.

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Clinical Research Center for Oral Diseases, Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, Xi'an, China.

Objective: The study aimed to investigate the involvement of astrocytes in the medullary dorsal horn (MDH) in the orofacial hyperalgesia induced by experimental tooth movement (ETM) and related mechanism.

Materials And Methods: Experimental tooth movement was produced with nickel-titanium alloy closed-coil spring fixed between the left maxillary first molar and the left upper incisor. Fluorocitrate was administrated through medullary subarachnoid at 3 days after ETM. Read More

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February 2021

Modulation of mechanosensory vibrissal responses in the trigeminocervical complex by stimulation of the greater occipital nerve in a rat model of trigeminal neuropathic pain.

J Headache Pain 2020 Aug 6;21(1):96. Epub 2020 Aug 6.

Department of Anatomy, Histology and Neuroscience, Medical School, Autonoma University of Madrid, c/ Arzobispo Morcillo 2, 28029, Madrid, Spain.

Background: Stimulation of the occipital or trigeminal nerves has been successfully used to treat chronic refractory neurovascular headaches such as migraine or cluster headache, and painful neuropathies. Convergence of trigeminal and occipital sensory afferents in the 'trigeminocervical complex' (TCC) from cutaneous, muscular, dural, and visceral sources is a key mechanism for the input-induced central sensitization that may underlie the altered nociception. Both excitatory (glutamatergic) and inhibitory (GABAergic and glycinergic) mechanisms are involved in modulating nociception in the spinal and medullary dorsal horn neurons, but the mechanisms by which nerve stimulation effects occur are unclear. Read More

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Safety and Effectiveness of Yttrium-90 Radioembolization around the Time of Immune Checkpoint Inhibitors for Unresectable Hepatic Metastases.

J Vasc Interv Radiol 2020 Aug;31(8):1233-1241

Department of Radiology, Division of Interventional Radiology, New York University School of Medicine, 560 First Ave., 2nd Floor, New York, NY 10016. Electronic address:

Purpose: To assess the safety and effectiveness of yttrium-90 radioembolization and checkpoint inhibitor immunotherapy within a short interval for the treatment of unresectable hepatic metastases.

Materials And Methods: This single-institution retrospective study included 22 patients (12 men; median age, 65 y ± 11) with unresectable hepatic metastases and preserved functional status (Eastern Cooperative Oncology Group performance status 0/1) who received immunotherapy and radioembolization within a 15-month period (median, 63.5 d; interquartile range, 19. Read More

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Exophytic nodule resembling a horn - an unusual presentation of metastatic cutaneous leiomyosarcoma.

Australas J Dermatol 2021 Feb 20;62(1):77-78. Epub 2020 Jul 20.

Department of Pathology, Christian Medical College, Vellore, India.

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February 2021

BCL11B-related disorder in two canadian children: Expanding the clinical phenotype.

Eur J Med Genet 2020 Sep 10;63(9):104007. Epub 2020 Jul 10.

Schulich School of Medicine and Dentistry, Western University, Department of Pediatrics, Division of Medical Genetics, London Health Sciences Centre, London, Ontario, Canada; Children's Health Research Institute, London, Ontario, Canada. Electronic address:

The product of the BCL11B (B-Cell Leukemia 11) gene is a bi-functional transcriptional regulator that can act as either a repressor or an activator. It plays an important role in the development of the nervous, immune, and cutaneous systems, and is also involved in dental and craniofacial development. BCL11B-Related Disorder (BCL11BRD) is a novel rare neurodevelopmental disorder associated with mutations in BCL11B. Read More

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September 2020

Cutaneous horn associated to seborrheic keratosis in eyelid margin.

Arch Soc Esp Oftalmol 2020 Nov 18;95(11):e86. Epub 2020 Jun 18.

Servicio de Anatomía Patológica, Complejo Hospitalario Universitario, Santiago de Compostela, La Coruña, España.

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November 2020

Transcutaneous Lateral Alveolar Ostectomy for Standing Surgical Extraction of Mandibular First Molar in an 8-Year-Old Miniature Horse.

J Vet Dent 2020 Mar 5;37(1):29-34. Epub 2020 Jun 5.

Salem Valley Veterinary Clinic, Salem, CT, USA.

An 8-year-old, 125 kg (275 lb) female miniature horse was evaluated for a persistently thickened left mandible and cutaneous fistula. Pulp horn defects were identified in pulp horns 1 and 3 of tooth 309 and occlusal pulp exposure was detected with a dental explorer. Radiography of the left mandibular dental quadrant revealed changes consistent with apical infection of tooth 309. Read More

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The Pathways and Processes Underlying Spinal Transmission of Low Back Pain: Observations From Dorsal Root Ganglion Stimulation Treatment.

Neuromodulation 2020 Apr 23. Epub 2020 Apr 23.

Department of Pain Management, Cleveland Clinic, Cleveland, OH, USA.

Background: Dorsal root ganglion stimulation (DRG-S) is a novel approach to treat chronic pain. Lead placement at L2 has been reported to be an effective treatment for axial low back pain (LBP) primarily of discogenic etiology. We have recently shown, in a diverse cohort including cases of multilevel instrumentation following extensive prior back surgeries, that DRG-S lead placement at T12 is another promising target. Read More

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Activation of α-adrenoceptors depresses synaptic transmission of myelinated afferents and inhibits pathways mediating primary afferent depolarization (PAD) in the in vitro mouse spinal cord.

Exp Brain Res 2020 May 22;238(5):1293-1303. Epub 2020 Apr 22.

Departamento de Fisiología, Biofísica y Neurociencias, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Cinvestav del IPN, Av. IPN 2508, San Pedro Zacatenco, 07360, Ciudad de México, Mexico.

Somatosensory afferent transmission strength is controlled by several presynaptic mechanisms that reduce transmitter release at the spinal cord level. We focused this investigation on the role of α-adrenoceptors in modulating sensory transmission in low-threshold myelinated afferents and in pathways mediating primary afferent depolarization (PAD) of neonatal mouse spinal cord. We hypothesized that the activation of α-adrenoceptors depresses low threshold-evoked synaptic transmission and inhibits pathways mediating PAD. Read More

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Recurrent Small Cell Carcinoma of the Lung With Cutaneous Metastasis in Breast.

Oncology (Williston Park) 2020 Apr 10;34(4). Epub 2020 Apr 10.

Lung cancer remains the leading cause of cancer-related deaths and the second leading cause of new cancer cases in the United States. Although more commonly involving hilar nodes, the liver, adrenal glands, bones, and the brain, lung cancer can metastasize to almost any organ. Metastases, although rare in the skin may be the first sign of a lung cancer or cutaneous metastases may present as a sign of recurrent disease. Read More

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Cutaneous horn with underlying squamous cell carcinoma on the footpad of a guinea pig.

J Small Anim Pract 2020 Jun 15;61(6):389. Epub 2020 Apr 15.

Institute of Veterinary Pathology, Freie Universitaet Berlin, Robert-von-Ostertag-Straße, 14163, Berlin, Germany.

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Recent advances in our understanding of the organization of dorsal horn neuron populations and their contribution to cutaneous mechanical allodynia.

J Neural Transm (Vienna) 2020 04 2;127(4):505-525. Epub 2020 Apr 2.

Institute of Neuroscience and Psychology, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, UK.

The dorsal horns of the spinal cord and the trigeminal nuclei in the brainstem contain neuron populations that are critical to process sensory information. Neurons in these areas are highly heterogeneous in their morphology, molecular phenotype and intrinsic properties, making it difficult to identify functionally distinct cell populations, and to determine how these are engaged in pathophysiological conditions. There is a growing consensus concerning the classification of neuron populations, based on transcriptomic and transductomic analyses of the dorsal horn. Read More

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Healing activity of hydrogel containing nanoemulsified β-caryophyllene.

Eur J Pharm Sci 2020 May 20;148:105318. Epub 2020 Mar 20.

Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil. Electronic address:

β-caryophyllene is a sesquiterpene present in the oil of many plant species, such as Copaifera sp., which has been shown to possesses potent anti-inflammatory action; however, its healing activity remains under study. The objectives of the present study were to produce a nanoemulsion containing β-caryophyllene followed by a hydrogel containing nanoemulsified β-caryophyllene, to evaluate the permeation profile in vitro, and to assess the in vivo healing activity, which is so far unexplored in the literature for pure β-caryophyllene and in pharmaceutical formulation. Read More

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Ultrasound-mediated topical delivery of econazole nitrate with potential for treating Raynaud's phenomenon.

Int J Pharm 2020 Apr 14;580:119229. Epub 2020 Mar 14.

Department of Medicine, Division of Rheumatology, University of Toledo, Toledo, USA.

The study aims to assess the ultrasound-assisted econazole nitrate (EN) permeation from topically applied formulations with potential for treating Raynaud's phenomenon. Optimization of ultrasound parameters such as the distance of the horn, application time and amplitude were performed. In vitro percutaneous absorption studies were performed using econazole formulations (F2_HPMC dispersion, F4_Lipoderm® Activemax™ Cream) across the ultrasound-treated porcine skin and were compared with the control group (skin samples without ultrasound). Read More

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Onycholemmal variant of keratoacanthoma centrifugum marginatum as an expression of mutated committed stem cells in a conceptual pathway.

Australas J Dermatol 2020 Aug 12;61(3):e354-e357. Epub 2020 Mar 12.

Newcastle Dermatology, Georgetown, New South Wales, Australia.

We describe a 43-year-old woman with a 10-year history of grossly hyperkeratotic nodules which progressively extended over the right ring finger. These involuted leaving pale, atrophic skin in their wake. At presentation, the advancing border had an arciform series of nodules in the pattern of keratoacanthoma centrifugum marginatum. Read More

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Neuropeptide Y tonically inhibits an NMDAR➔AC1➔TRPA1/TRPV1 mechanism of the affective dimension of chronic neuropathic pain.

Neuropeptides 2020 Apr 24;80:102024. Epub 2020 Jan 24.

Department of Physiology, University of Kentucky Medical Center, Lexington, KY, USA; Department of Anesthesiology and Perioperative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Center for Pain Research, University of Pittsburgh, Pittsburgh, PA, USA; Pittsburgh Project to end Opioid Misuse, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address:

Transection of the sural and common peroneal branches of the sciatic nerve produces cutaneous hypersensitivity at the tibial innervation territory of the mouse hindpaw that resolves within a few weeks. We report that interruption of endogenous neuropeptide Y (NPY) signaling during remission, with either conditional NPY knockdown in NPY mice or intrathecal administration of the Y1 receptor antagonist BIBO3304, reinstated hypersensitivity. These data indicate that nerve injury establishes a long-lasting latent sensitization of spinal nociceptive neurons that is masked by spinal NPY-Y1 neurotransmission. Read More

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Squamous cell carcinoma of the nose presenting with a giant cutaneous horn: A unique clinical presentation.

J Dermatol 2020 May 2;47(5):e185-e186. Epub 2020 Mar 2.

Department of Dermatology, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan.

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