Altered intrinsic and synaptic properties of lumbosacral dorsal horn neurons in a mouse model of colitis.
- Kristen E Farrell,
- Simon Keely,
- Marjorie M Walker,
- Alan M Brichta,
- Brett A Graham,
- Robert J Callister
Neuroscience 2017 Aug 23;362:152-167. Epub 2017 Aug 23.
School of Biomedical Sciences & Pharmacy, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute (HMRI), Rankin Park, NSW 2305, Australia. Electronic address:
Visceral pain in inflammatory and functional gastrointestinal conditions is a major clinical problem. The exact mechanisms underlying the development of pain, during and after visceral inflammation are unknown. However, clinical and pre-clinical evidence suggests plasticity within the spinal cord dorsal horn is a contributing factor. Read More