1,291 results match your criteria Cutaneous Horn


Dynamic expression of glial fibrillary acidic protein and ionized calcium binding adaptor molecule 1 in the mouse spinal cord dorsal horn under pathological pain states.

Neurol Res 2019 Apr 19:1-11. Epub 2019 Apr 19.

a Department of Physiology, Laboratory of Pain Neurobiology, Ribeirão Preto School of Medicine , University of São Paulo , Ribeirão Preto , Brazil.

Objective: Animal models of chronic pain have demonstrated that glial cells are promising target for development of analgesic drugs. However, preclinical studies on glial response under chronic pain conditions vary depending on the cellular markers, the species used, the experimental design and model. Therefore, we investigate the expression profile of GFAP and Iba-1 during the behavioral manifestation of sensory disorder in inflammatory and neuropathic pain models. Read More

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http://dx.doi.org/10.1080/01616412.2019.1603804DOI Listing

Tiling and somatotopic alignment of mammalian low-threshold mechanoreceptors.

Proc Natl Acad Sci U S A 2019 Apr 17. Epub 2019 Apr 17.

Department of Neurobiology, Harvard Medical School, Boston, MA 02115;

Innocuous mechanical stimuli acting on the skin are detected by sensory neurons, known as low-threshold mechanoreceptors (LTMRs). LTMRs are classified based on their response properties, action potential conduction velocity, rate of adaptation to static indentation of the skin, and terminal anatomy. Here, we report organizational properties of the cutaneous and central axonal projections of the five principal hairy skin LTMR subtypes. Read More

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http://dx.doi.org/10.1073/pnas.1901378116DOI Listing
April 2019
2 Reads

Cutaneous Rhinosporidiosis Presenting as Cutaneous Horn and Verrucous Plaque.

Indian Dermatol Online J 2019 Mar-Apr;10(2):178-179

Department of Pathology, Bhubaneswar, Odisha, India.

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http://dx.doi.org/10.4103/idoj.IDOJ_106_18DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6434746PMC

Neuronal diversity in the somatosensory system: bridging the gap between cell type and function.

Curr Opin Neurobiol 2019 Apr 3;56:167-174. Epub 2019 Apr 3.

Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Rd, La Jolla, CA 92037, USA. Electronic address:

A recent flurry of genetic studies in mice have provided key insights into how the somatosensory system is organized at a cellular level to encode itch, pain, temperature, and touch. These studies are largely predicated on the idea that functional cell types can be identified by their unique developmental provenance and gene expression profile. However, the extent to which gene expression profiles can be correlated with functional cell types and circuit organization remains an open question. Read More

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http://dx.doi.org/10.1016/j.conb.2019.03.002DOI Listing
April 2019
2 Reads

The supra-iliac anterior quadratus lumborum block: a cadaveric study and case series.

Can J Anaesth 2019 Mar 11. Epub 2019 Mar 11.

Department of Anesthesia, Toronto Western Hospital, University of Toronto, Toronto, ON, Canada.

Purpose: The local anesthetic injectate spread with fascial plane blocks and corresponding clinical outcomes may vary depending on the site of injection. We developed and evaluated a supra-iliac approach to the anterior quadratus lumborum (QL) block and hypothesized that this single injection might successfully block the lumbar and sacral plexus in cadavers and provide analgesia for patients undergoing hip surgery.

Methods: Ultrasound-guided bilateral supra-iliac anterior QL blocks were performed with 30 mL of India ink dye in six fresh adult cadavers. Read More

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http://dx.doi.org/10.1007/s12630-019-01312-zDOI Listing
March 2019
7 Reads

Central expression of synaptophysin and synaptoporin in nociceptive afferent subtypes in the dorsal horn.

Sci Rep 2019 Mar 12;9(1):4273. Epub 2019 Mar 12.

Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS, 39216, USA.

Central sprouting of nociceptive afferents in response to neural injury enhances excitability of nociceptive pathways in the central nervous system, often causing pain. A reliable quantification of central projections of afferent subtypes and their synaptic terminations is essential for understanding neural plasticity in any pathological condition. We previously characterized central projections of cutaneous nociceptive A and C fibers, selectively labeled with cholera toxin subunit B (CTB) and Isolectin B4 (IB4) respectively, and found that they expressed a general synaptic molecule, synaptophysin, largely depending on afferent subtypes (A vs. Read More

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http://dx.doi.org/10.1038/s41598-019-40967-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6414693PMC
March 2019
2 Reads

Just a cutaneous (keratotic) horn?

BMJ 2019 Mar 7;364:l595. Epub 2019 Mar 7.

Silverdale Medical Practice, Salford, Manchester, UK.

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http://dx.doi.org/10.1136/bmj.l595DOI Listing

Distinct Modes of Presynaptic Inhibition of Cutaneous Afferents and Their Functions in Behavior.

Neuron 2019 Apr 27;102(2):420-434.e8. Epub 2019 Feb 27.

Department of Neurobiology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

Presynaptic inhibition (PSI) of primary sensory neurons is implicated in controlling gain and acuity in sensory systems. Here, we define circuit mechanisms and functions of PSI of cutaneous somatosensory neuron inputs to the spinal cord. We observed that PSI can be evoked by different sensory neuron populations and mediated through at least two distinct dorsal horn circuit mechanisms. Read More

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http://dx.doi.org/10.1016/j.neuron.2019.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6472967PMC
April 2019
1 Read

Intensity-modulated radiation therapy with simultaneous integrated boost for locally advanced breast cancer: a prospective study on toxicity and quality of life.

Sci Rep 2019 Feb 26;9(1):2759. Epub 2019 Feb 26.

Academic Department of Radiation Oncology, Centre Oscar Lambret, 3 rue Frédéric Combemale, F-59000, Lille, France.

Radiotherapy after breast conserving surgery and mastectomy with node positive disease has been shown to reduce risk of recurrence and mortality in the treatment of breast cancer. Intensity-modulated radiation therapy (IMRT) after conservative surgery offers several advantages over conventional RT including improved acute and late toxicity and quality of life (QoL). We undertook this study to prospectively evaluate acute (≤90 days after last dose of radiotherapy) and long-term (>90 days) cutaneous, esophageal, and fibrosis toxicity and QoL in breast cancer patients treated by adjuvant IMRT after breast surgery. Read More

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http://dx.doi.org/10.1038/s41598-019-39469-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391390PMC
February 2019
7 Reads

A new method of administering local anesthesia for calf disbudding: Findings from a comparative on-farm study in New Zealand.

J Dairy Sci 2019 Mar 11;102(3):2492-2506. Epub 2019 Jan 11.

Vetlife Temuka, Temuka 7920, New Zealand.

Anesthesia of the horn bud for calf disbudding commonly is attained by injection of local anesthetic over branches of the cornual nerve, with anesthesia achieved in 3 to 20 min. With experienced and trained staff, this method is effective in 88 to 100% of calves. Variability in response and time of onset can compromise calf welfare if calves are disbudded before anesthesia is attained. Read More

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http://dx.doi.org/10.3168/jds.2018-15033DOI Listing
March 2019
1 Read

Differential innervation within a transverse plane of spinal gray matter by sensorimotor cortices, with special reference to the somatosensory cortices.

J Comp Neurol 2019 Jun 1;527(8):1401-1415. Epub 2019 Feb 1.

Department of Physiology, Teikyo University School of Medicine, Tokyo, Japan.

The corticospinal (CS) neurons projecting to the cervical cord distribute not only in motor-related cortical areas, but also in somatosensory areas, including the primary somatosensory cortex (S1). The exact functions of these widely distributed CS neurons are largely unknown, however. In this study, we injected mice with adeno-associated virus encoding membrane-binding fluorescent proteins to investigate the distribution of axons from CS neurons in different regions within a broad cortical area. Read More

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http://doi.wiley.com/10.1002/cne.24626
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http://dx.doi.org/10.1002/cne.24626DOI Listing
June 2019
3 Reads

Multiple eruptive cutaneous horns on the scalp.

Clin Exp Dermatol 2019 Jan 2. Epub 2019 Jan 2.

University of Arizona, Department of Medicine, Division of Dermatology, Tucson, AZ, USA.

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http://doi.wiley.com/10.1111/ced.13866
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http://dx.doi.org/10.1111/ced.13866DOI Listing
January 2019
10 Reads

A Giant Cutaneous Horn on the Cheek.

Facial Plast Surg 2018 Dec 28;34(6):663-664. Epub 2018 Dec 28.

Department of Oral and Maxillofacial Surgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong, China.

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http://dx.doi.org/10.1055/s-0038-1675635DOI Listing
December 2018
2 Reads

Mediolateral and dorsoventral projection patterns of cutaneous afferents within transverse planes of the mouse spinal dorsal horn.

J Comp Neurol 2019 Apr 20;527(5):972-984. Epub 2018 Dec 20.

Department of Physiology, Teikyo University School of Medicine, Tokyo, Japan.

The central projection patterns of cutaneous afferents from the forelimb and shoulder of mice were studied in the spinal dorsal horn after intracutaneous injection of AlexaFluor 488-conjugated and/or 594-conjugated cholera toxin subunit B (CTB). Based on their dermatomes, the following eight skin regions are thought to be innervated by spinal nerves from the sixth to eighth cervical spinal nerve roots: the dorsal surface of the shoulder, brachium, proximal forearm, distal forearm, hand, palmar surface of the second and third digits, and palm. The termination areas of afferents from the dorsal surface of the shoulder and forearm were narrow, distributed in a dorsoventral direction, and aligned in order from lateral to medial within the sixth to eighth cervical dorsal horns. Read More

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http://dx.doi.org/10.1002/cne.24593DOI Listing
April 2019
7 Reads

Central neural substrates involved in temperature discrimination, thermal pain, thermal comfort, and thermoregulatory behavior.

Handb Clin Neurol 2018 ;156:317-338

Atkinson Research Laboratory, Barrow Neurological Institute, Phoenix, AZ, United States. Electronic address:

A phylogenetically novel pathway that emerged with primate encephalization is described, which conveys high-fidelity cutaneous thermosensory activity in "labeled lines" to a somatotopic map in the dorsal posterior insular cortex. It originates in lamina I of the superficial dorsal horn and ascends by way of the lateral spinothalamic tract and a distinct region in posterolateral thalamus. It evolved from the homeostatic sensory activity that represents the physiologic (interoceptive) condition of the body and drives the central autonomic network, which underlies all affective feelings from the body. Read More

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https://linkinghub.elsevier.com/retrieve/pii/B97804446391270
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http://dx.doi.org/10.1016/B978-0-444-63912-7.00019-9DOI Listing
March 2019
22 Reads

Involvement of mGluR5 and TRPV1 in visceral nociception in a rat model of uterine cervical distension.

Mol Pain 2018 Jan-Dec;14:1744806918816850. Epub 2018 Nov 16.

1 Department of Anesthesia, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.

Metabotropic glutamate receptor 5 (mGluR5) and transient receptor potential vanilloid subtype 1 (TRPV1) have been shown to play critical roles in the transduction and modulation of cutaneous nociception in the central nervous system. However, little is known regarding the possible involvement of mGluR5 and TRPV1 in regulating visceral nociception from the uterine cervix. In this study, we used a rat model of uterine cervical distension to examine the effects of noxious stimuli to the uterine cervix on expression of spinal mGluR5 and TRPV1. Read More

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http://dx.doi.org/10.1177/1744806918816850DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302284PMC
April 2019
17 Reads

Lamina-specific population encoding of cutaneous signals in the spinal dorsal horn using multi-electrode arrays.

J Physiol 2019 Jan 5;597(2):377-397. Epub 2018 Dec 5.

School of Life Sciences, The University of Nottingham, Nottingham, NG7 2UH, UK.

Key Points: Traditional, widely used in vivo electrophysiological techniques for the investigation of spinal processing of somatosensory information fail to account for the diverse functions of each lamina. To overcome this oversimplification, we have used multi-electrode arrays, in vivo, to simultaneously record neuronal activity across all laminae of the spinal dorsal horn. Multi-electrode arrays are sensitive enough to detect lamina- and region-specific encoding of different subtypes of afferent fibres and to detect short-lived changes in synaptic plasticity as measured by the application of cutaneous electrical stimulation of varying intensity and frequency. Read More

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http://doi.wiley.com/10.1113/JP277036
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http://dx.doi.org/10.1113/JP277036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6332738PMC
January 2019
17 Reads

Extrasynaptic αGABA receptors on proprioceptive afferents produce a tonic depolarization that modulates sodium channel function in the rat spinal cord.

J Neurophysiol 2018 12 26;120(6):2953-2974. Epub 2018 Sep 26.

Neuroscience and Mental Health Institute and Faculty of Rehabilitation Medicine, University of Alberta , Edmonton, AB , Canada.

Activation of GABA receptors on sensory axons produces a primary afferent depolarization (PAD) that modulates sensory transmission in the spinal cord. While axoaxonic synaptic contacts of GABAergic interneurons onto afferent terminals have been extensively studied, less is known about the function of extrasynaptic GABA receptors on afferents. Thus, we examined extrasynaptic αGABA receptors on low-threshold proprioceptive (group Ia) and cutaneous afferents. Read More

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https://www.physiology.org/doi/10.1152/jn.00499.2018
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http://dx.doi.org/10.1152/jn.00499.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6337028PMC
December 2018
4 Reads

Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis.

JAMA Oncol 2018 Dec;4(12):1721-1728

Vanderbilt Ingram Cancer Center, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.

Importance: Immune checkpoint inhibitors (ICIs) are now a mainstay of cancer treatment. Although rare, fulminant and fatal toxic effects may complicate these otherwise transformative therapies; characterizing these events requires integration of global data.

Objective: To determine the spectrum, timing, and clinical features of fatal ICI-associated toxic effects. Read More

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http://oncology.jamanetwork.com/article.aspx?doi=10.1001/jam
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http://dx.doi.org/10.1001/jamaoncol.2018.3923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6440712PMC
December 2018
42 Reads

Penile cutaneous horn: still an enigma.

BMJ Case Rep 2018 Sep 10;2018. Epub 2018 Sep 10.

Department of Urology, King George's Medical University, Lucknow, Uttar Pradesh, India.

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http://casereports.bmj.com/lookup/doi/10.1136/bcr-2018-22593
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http://dx.doi.org/10.1136/bcr-2018-225930DOI Listing
September 2018
3 Reads

Rheumatoid-nodule-like cutaneous granuloma associated with recombinase activating gene 1-deficient severe combined immunodeficiency: A rare case.

J Cutan Pathol 2018 Dec 9;45(12):940-943. Epub 2018 Oct 9.

Department of Pathology and Laboratory Services, Walter Reed National Military Medical Center, Bethesda, Maryland.

Cutaneous granulomas without detectable infectious etiology rarely occur in children and adults with primary immunodeficiency disorders. These cutaneous granulomas are primarily seen in combined variable immunodeficiency, ataxia-telangiectasia, and severe combined immunodeficiency (SCID) and can emulate the reaction patterns seen in sarcoidosis and granuloma annulare. To date, the literature has described only six cases of non-infectious cutaneous granulomas in SCID. Read More

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http://doi.wiley.com/10.1111/cup.13355
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http://dx.doi.org/10.1111/cup.13355DOI Listing
December 2018
10 Reads

Heterogenity of dermal fibroblasts: skin equivalent models that aim to recreate the cutaneous microenvironment.

Br J Dermatol 2018 Aug;179(2):248-250

Centre for Dermatology Research, Faculty of Biology, Medicine and Health, The University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PL, U.K.

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http://dx.doi.org/10.1111/bjd.16773DOI Listing
August 2018
1 Read

Neuritis and vinblastine-induced axonal transport disruption lead to signs of altered dorsal horn excitability.

Mol Pain 2018 Jan-Dec;14:1744806918799581. Epub 2018 Aug 21.

1 Department of Neuroscience, Brighton and Sussex Medical School, University of Sussex, UK.

Background: Many patients with neuropathic pain present without signs of nerve injury on routine clinical examination. Some of these patients may have inflamed peripheral nerves (neuritis). In this study, we have examined whether neuritis causes changes within the dorsal horn that may contribute to a central pain mechanism. Read More

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http://dx.doi.org/10.1177/1744806918799581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6243410PMC
February 2019
2 Reads

Penile Cutaneous Horn in a 22-month-old Child: A Rare Case Report.

J Indian Assoc Pediatr Surg 2018 Jul-Sep;23(3):167-168

Department of Pediatric Surgery, Sardar Patel Medical College, Bikaner, Rajasthan, India.

Cutaneous horn is a horn-like hyperkeratotic lesion. Its presence over penis is unusual and rare. Herein, we report a case of horn of penis in a 22-month-old child. Read More

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http://dx.doi.org/10.4103/jiaps.JIAPS_176_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6042168PMC
July 2018
1 Read

Chronic Inflammation Promotes Skin Carcinogenesis in Cancer-Prone Discoid Lupus Erythematosus.

J Invest Dermatol 2019 Jan 17;139(1):62-70. Epub 2018 Jul 17.

Center for Cancer Immunology and Cutaneous Biology Research Center, Department of Dermatology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

High-risk skin cancer is a rare, but severe, complication associated with discoid lupus erythematosus (DLE). Chronic scar, inflammation, UVR, and immunosuppressive medications are proposed explanations for this heightened skin cancer risk; however, the exact mechanism driving skin carcinogenesis in DLE is unknown. The distinct co-localization of multiple independent skin cancers with areas of active inflammation in two DLE patients followed over 8 years strongly suggested that lupus inflammation promotes skin carcinogenesis in DLE. Read More

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http://dx.doi.org/10.1016/j.jid.2018.06.185DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6309656PMC
January 2019
9 Reads

A facial cutaneous horn.

Pediatr Dermatol 2018 Jul;35(4):515-516

Section of Dermatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://dx.doi.org/10.1111/pde.13462DOI Listing
July 2018
1 Read

Late-onset solitary porokeratotic eccrine ostial and dermal duct nevus.

JAAD Case Rep 2018 Jun 30;4(5):434-436. Epub 2018 Apr 30.

Department of Dermatology, Roswell Park Cancer Institute, Buffalo, New York.

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http://dx.doi.org/10.1016/j.jdcr.2017.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031572PMC

Therapeutic potential of Pak1 inhibition for pain associated with cutaneous burn injury.

Mol Pain 2018 Jan-Dec;14:1744806918788648. Epub 2018 Jun 29.

1 Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA.

Painful burn injuries are among the most debilitating form of trauma, globally ranking in the top 15 leading causes of chronic disease burden. Despite its prevalence, however, chronic pain after burn injury is under-studied. We previously demonstrated the contribution of the Rac1-signaling pathway in several models of neuropathic pain, including burn injury. Read More

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http://dx.doi.org/10.1177/1744806918788648DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6053256PMC
December 2018
4 Reads

Squamous Cell Carcinoma Manifested as a Cutaneous Horn: A Key to Early Detection.

Yonago Acta Med 2018 Jun 18;61(2):140-141. Epub 2018 Jun 18.

Division of Dermatology, Department of Medicine of Sensory and Motor Organs, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8504, Japan.

We report a case of squamous cell carcinoma manifested as a cutaneous horn. A 92-year-old man was referred to our department for evaluation of a 3-month history of a keratotic cutaneous horn on the left side of his neck. The height of the cutaneous horn was larger than the diameter of erythema at the base. Read More

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6015795PMC
June 2018
2 Reads

Tumor CDKN2A-Associated JAK2 Loss and Susceptibility to Immunotherapy Resistance.

J Natl Cancer Inst 2018 Jun;110(6):677-681

Department of Dermatology, University Hospital Essen, University Duisburg-Essen, and German Cancer Consortium partner site Essen/Düsseldorf, Essen, Germany (DKTK).

Poor clinical responses to checkpoint blockade with anti-CTLA-4 and anti-PD-1 antibodies in melanoma have recently been associated with acquired IFNγ resistance that protects tumor cells from the antiproliferative and pro-apoptotic cytokine activity. IFNγ-resistant melanoma cells very often lack functional expression of the IFNγ signaling pathway gene JAK2 due to gene deletions or inactivating gene mutations. Analyzing melanoma cell lines (n = 46, applying next-generation targeted sequencing and single nucleotide polymorphism arrays) as well as available genomic data sets from The Cancer Genome Atlas (TCGA) tumor tissue samples (cutaneous melanoma n = 367, lung squamous cell carcinoma n = 501, bladder urothelial carcinoma n = 408, breast invasive carcinoma n = 768, colorectal adenocarcinoma n = 257), we demonstrate that the frequent chromosomal losses of the tumor suppressor CDKN2A in melanoma and other tumor entities enhance the susceptibility to IFNγ resistance by concomitant deletion of the JAK2 gene (odds ratio = 223. Read More

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http://dx.doi.org/10.1093/jnci/djx271DOI Listing
June 2018
4 Reads

Endothelial microparticles and vascular parameters in subjects with and without arterial hypertension and coronary artery disease.

Data Brief 2018 Aug 8;19:495-500. Epub 2018 May 8.

Division of Cardiology, Pulmonology, and Vascular Medicine, Medical Faculty, University Duesseldorf, Duesseldorf, Germany.

Endothelial microparticles (EMPs) are markers of endothelial injury and activation. The role of EMPs in arterial hypertension is not well understood and EMPs are increased both in arterial hypertension and coronary artery disease (CAD). The data presented here show EMPs as defined by CD31/41, CD62e, and CD144 surface markers and vascular hemodynamic parameters including office and central blood pressure, heart rate, aortic augmentation index, pulse wave velocity, flow-mediated dilation, nitroglycerin-mediated dilation, brachial artery diameter, hyperemic wall shear stress, and laser Doppler perfusion of the cutaneous microcirculation of normotensives and hypertensives with and without CAD. Read More

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http://dx.doi.org/10.1016/j.dib.2018.04.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5997624PMC
August 2018
4 Reads

The effects of a synthetic analogue of the Bovine Appeasing Pheromone on milk yield and composition in Valdostana dairy cows during the move from winter housing to confined lowland pastures.

J Dairy Res 2018 May;85(2):174-177

IRSEA Research Institute Semiochemistry and Applied Ethology,Apt,France.

This Research Communication describes the effects of a synthetic analogue of the Bovine Appeasing Pheromone (BAP) on milk parameters in Valdostana dairy cows during the first turning out from tie-stalls to confined lowland pastures around the farms. Thirty healthy lactating Valdostana cows were enroled in the study and randomly divided into 2 groups: experimental group (EG, n = 15) and control group (CG, n = 15). The two groups were separately housed in the same farm and managed outside in two different pens. Read More

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http://dx.doi.org/10.1017/S0022029918000262DOI Listing
May 2018
20 Reads
1.598 Impact Factor

Nail-patella syndrome: clinical clues for making the diagnosis.

Cutis 2018 Feb;101(2):126-129

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, Florida, USA.

Nail-patella syndrome (NPS) is a rare autosomal-dominant disorder characterized by the classic triad of fingernail dysplasia, patellar absence/hypoplasia, and presence of iliac horns. We describe the various features of NPS, focusing on dermatologic and musculoskeletal findings. A 69-year-old man presented to the dermatology clinic for a routine skin cancer screening. Read More

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February 2018
5 Reads

A case of cutaneous horn arising in verrucous epidermal nevus.

Indian J Dermatol Venereol Leprol 2019 Jan-Feb;85(1):74-75

Department of Pathology, AIIMS, Jodhpur, Rajasthan, India.

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http://dx.doi.org/10.4103/ijdvl.IJDVL_435_17DOI Listing
April 2019
3 Reads

Repeated touch and needle-prick stimulation in the neonatal period increases the baseline mechanical sensitivity and postinjury hypersensitivity of adult spinal sensory neurons.

Pain 2018 Jun;159(6):1166-1175

Department of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Kwok is now with the Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada.

Noxious stimulation at critical stages of development has long-term consequences on somatosensory processing in later life, but it is not known whether this developmental plasticity is restricted to nociceptive pathways. Here, we investigate the effect of repeated neonatal noxious or innocuous hind paw stimulation on adult spinal dorsal horn cutaneous mechanical sensitivity. Neonatal Sprague-Dawley rats of both sexes received 4 unilateral left hind paw needle pricks (NPs, n = 13) or 4 tactile (cotton swab touch) stimuli, per day (TC, n = 11) for the first 7 days of life. Read More

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http://dx.doi.org/10.1097/j.pain.0000000000001201DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5959002PMC
June 2018
5 Reads

Filiform Verrucous Sarcoidosis of the Face: A Warty Report.

J Cutan Med Surg 2018 Jul/Aug;22(4):424-426. Epub 2018 Mar 5.

1 Department of Dermatology, Texas Tech Health Sciences Center, Lubbock, TX, USA.

Sarcoidosis is a multisystem inflammatory condition of unknown etiology. Variability in the cutaneous features of sarcoidosis is profound, and its protean manifestations affirm the condition's designation as one of dermatology's "great mimics." Cutaneous phenotypes of sarcoidosis include but are by no means limited to ichthyosiform, alopecic, erythrodermic, angiolupoid, and verrucous variants. Read More

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http://dx.doi.org/10.1177/1203475418763590DOI Listing
December 2018
7 Reads

Skin lesions in Aubrac cows strongly associated with fly bites (Haematobia irritans).

Vet Dermatol 2018 Jun 1;29(3):254-e94. Epub 2018 Mar 1.

UP Interactions Cellules Environnement, VetAgro Sup, Université de Lyon, 1 Avenue Bourgelat, 69280, Marcy l'Etoile, France.

Background: The horn fly Haematobia irritans is known to cause problems in cattle including weight loss and decreased milk production; cutaneous lesions have not been widely reported and descriptions of the clinical manifestations are quite variable.

Hypothesis/objectives: This study describes the clinical and histopathological lesions of several Aubrac cows that presented with focal to confluent areas of alopecia, skin scaling and thickening, suspected to be induced by H. irritans bites. Read More

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http://dx.doi.org/10.1111/vde.12530DOI Listing
June 2018
10 Reads

Cutaneous horn: A mask to underlying malignancy.

J Oral Maxillofac Pathol 2018 Jan;22(Suppl 1):S87-S90

Department of Oral Pathology, Manubhai Patel Dental College, Vadodara, Gujarat, India.

Cutaneous horns () are uncommon lesions consisting of keratotic material resembling that of an animal horn. It is a conical- or cylindrical-shaped excessive hyperkeratosis of variable size ranging from few millimeters to several centimeters with a variable in size and shape, such as cylindrical, conical, pointed, transversely or longitudinally corrugated, or curved like a ram's horn. The lesions typically occur in sun-exposed areas, particularly the face, ear, nose, forearms and dorsum of hands. Read More

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http://dx.doi.org/10.4103/jomfp.JOMFP_156_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5824527PMC
January 2018
6 Reads

Urinary tract infections following radical cystectomy and urinary diversion: a review of 1133 patients.

World J Urol 2018 May 25;36(5):775-781. Epub 2018 Jan 25.

USC Institute of Urology, USC/Norris Comprehensive Cancer Center, University of Southern California, 1441 Eastlake Avenue, Suite 7416, Los Angeles, CA, 90089, USA.

Objective: To investigate the incidence and microbiology of urinary tract infection (UTI) within 90 days following radical cystectomy (RC) and urinary diversion.

Methods: We reviewed 1133 patients who underwent RC for bladder cancer at our institution between 2003 and 2013; 815 patients (72%) underwent orthotopic diversion, 274 (24%) ileal conduit, and 44 (4%) continent cutaneous diversion. 90-day postoperative UTI incidence, culture results, antibiotic sensitivity/resistance and treatment were recorded through retrospective review. Read More

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http://link.springer.com/10.1007/s00345-018-2181-2
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http://dx.doi.org/10.1007/s00345-018-2181-2DOI Listing
May 2018
20 Reads

Lumbar to sacral root rerouting to restore bladder function in a feline spinal cord injury model: Urodynamic and retrograde nerve tracing results from a pilot study.

Neurourol Urodyn 2018 Jan 4;37(1):153-162. Epub 2018 Jan 4.

Department of Anatomy and Cell Biology, Lewis Katz School of Medicine at Temple University, Philadelphia, Pennsylvania.

Aims: Lumbar to sacral rerouting surgery can potentially allow voiding via a skin-central nervous system-bladder reflex pathway. Here, we assessed if this surgery was effective in treating neurogenic bladder dysfunction/sphincter in felines.

Methods: Eight cats underwent spinal cord transection (SCT) at thoracic level 10/11. Read More

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http://dx.doi.org/10.1002/nau.23394DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5785433PMC
January 2018
20 Reads

[A long-standing swelling on the shoulder].

Ned Tijdschr Geneeskd 2017;161:D1649

Ziekenhuisgroep Twente, Almelo.

We present a 49-year-old woman with a cutaneous horn on the right shoulder since 20 years. Cutaneous horn is a clinical diagnosis referring to a benign or malignant lesion of the skin with a conical projection of cornified material. It is most common on sun-exposed skin. Read More

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December 2018
1 Read

Erosive Pustular Dermatosis of the Scalp with Urate-Like Crystals.

Case Rep Dermatol Med 2017 8;2017:1536434. Epub 2017 Oct 8.

Auckland University of Technology, Auckland 1142, New Zealand.

Follicular urate-like crystals were first described in Necrotizing Infundibular Crystalline Folliculitis (NICF), a rare cutaneous disorder with multiple waxy folliculocentric papules. Similar crystal accumulation may be seen within follicular infundibulae as an incidental finding. We describe a case showing identical crystals occurring within the horn-like crusts of a patient with erosive pustular dermatosis of the scalp (EPDS), a condition which due to its presentation can often be mistaken for nonmelanoma skin cancer. Read More

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http://dx.doi.org/10.1155/2017/1536434DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5651126PMC
October 2017
3 Reads

Downregulation of spinal astrocytic connexin43 leads to upregulation of interleukin-6 and cyclooxygenase-2 and mechanical hypersensitivity in mice.

Glia 2018 02 6;66(2):428-444. Epub 2017 Nov 6.

Department of Pharmacology, Hiroshima University Graduate School of Biomedical & Health Sciences, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Connexin43 (Cx43), involved in intercellular signaling, is expressed in spinal dorsal horn astrocytes and crucial in the maintenance of neuropathic pain. Downregulation of spinal astrocytic Cx43 in mice enhances glutamatergic neurotransmission by decreasing glutamate transporter GLT-1 expression, resulting in cutaneous hypersensitivity. Decreased expression of astrocytic Cx43 could lead to altered expression of other nociceptive molecules. Read More

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http://dx.doi.org/10.1002/glia.23255DOI Listing
February 2018
12 Reads

Soft-tissue infection secondary to cellulitis killed St. John of the Cross (1542-1591).

Infection 2018 Apr 31;46(2):267-269. Epub 2017 Oct 31.

Department of Medicine, "San Giovanni di Dio" Hospital, Gorizia, Italy.

Purpose: St. John of the Cross (1542-1591) died aged 49 years after 3 months of excruciating pain following a trivial lesion in his right foot. Erysipelas, a superficial bacterial infection of the skin, and subsequent sepsis were previously suggested as the cause of his death. Read More

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http://dx.doi.org/10.1007/s15010-017-1089-xDOI Listing
April 2018
13 Reads

Penile cutaneous horn: a rare case report and review of the literature.

Asian J Androl 2018 Jul-Aug;20(4):407-408

Department of Urology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai 200240, China.

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http://dx.doi.org/10.4103/aja.aja_48_17DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6038154PMC
November 2017
8 Reads

Baseline factors affecting closure of venous leg ulcers.

J Vasc Surg Venous Lymphat Disord 2017 11;5(6):829-835.e1

Smith & Nephew, Inc, Fort Worth, Tex; Department of Pediatrics, University of North Texas Health Science Center, Fort Worth, Tex.

Objective: The objective of this study was to characterize factors associated with closure of venous leg ulcers (VLUs) in a pooled analysis of subjects from three randomized clinical trials.

Methods: Closure of VLUs after treatment with HP802-247, an allogeneic living cell therapy consisting of growth-arrested human keratinocytes and fibroblasts, vs standard therapy with compression bandaging was evaluated in three phase 3 clinical trials of similar design. Two trials enrolled subjects with VLUs ranging from 2 cm to 12 cm in area with 12-week treatment periods; the third trial enrolled subjects with VLUs between >12 cm and ≤36 cm with a 16-week treatment period. Read More

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https://linkinghub.elsevier.com/retrieve/pii/S2213333X173035
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http://dx.doi.org/10.1016/j.jvsv.2017.06.017DOI Listing
November 2017
28 Reads

Managing actinic keratosis in primary care.

Practitioner 2016 10;260(1797):25-9

Actinic, or solar, keratosis is caused by chronic ultraviolet-induced damage to the epidermis. In the UK, 15-23% of individuals have actinic keratosis lesions. Risk factors include: advanced age; male gender; cumulative sun exposure or phototherapy; Fitzpatrick skin phototypes I-II; long-term immuno-suppression and genetic syndromes e. Read More

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October 2016
46 Reads

Delta Opioid Receptor Expression and Function in Primary Afferent Somatosensory Neurons.

Handb Exp Pharmacol 2018 ;247:87-114

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford Neurosciences Institute, Stanford University School of Medicine, Palo Alto, CA, USA.

The functional diversity of primary afferent neurons of the dorsal root ganglia (DRG) generates a variety of qualitatively and quantitatively distinct somatosensory experiences, from shooting pain to pleasant touch. In recent years, the identification of dozens of genetic markers specifically expressed by subpopulations of DRG neurons has dramatically improved our understanding of this diversity and provided the tools to manipulate their activity and uncover their molecular identity and function. Opioid receptors have long been known to be expressed by discrete populations of DRG neurons, in which they regulate cell excitability and neurotransmitter release. Read More

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http://link.springer.com/10.1007/164_2017_58
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http://dx.doi.org/10.1007/164_2017_58DOI Listing
January 2019
30 Reads

Spinal Circuits for Touch, Pain, and Itch.

Annu Rev Physiol 2018 02 27;80:189-217. Epub 2017 Sep 27.

Molecular Neurobiology Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037, USA; email:

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors and for the dynamic control of movement in response to external stimuli. This review outlines recent efforts using genetic approaches in the mouse to map the spinal cord circuits that transmit and gate the cutaneous somatosensory modalities of touch, pain, and itch. Recent studies have revealed an underlying modular architecture in which nociceptive, pruritic, and innocuous stimuli are processed by distinct molecularly defined interneuron cell types. Read More

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http://dx.doi.org/10.1146/annurev-physiol-022516-034303DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5891508PMC
February 2018
14 Reads

Malignant Melanoma With Massive Crust Mimicking a Cutaneous Horn: An Unexpected Finding.

Am J Dermatopathol 2018 11;40(11):869-871

Cátedra de Dermatología Prof. Dr. Miguel Martínez, Hospital de Clínicas Dr. Manuel Quintela, Montevideo, Uruguay.

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http://dx.doi.org/10.1097/DAD.0000000000001002DOI Listing
November 2018
7 Reads