Using an engineered glutamate-gated chloride channel to silence sensory neurons and treat neuropathic pain at the source.
- Greg A Weir,
- Steven J Middleton,
- Alex J Clark,
- Tarun Daniel,
- Nikita Khovanov,
- Stephen B McMahon,
- David L Bennett
Brain 2017 10;140(10):2570-2585
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
See Basbaum (doi:10.1093/brain/awx227) for a scientific commentary on this article. Peripheral neuropathic pain arises as a consequence of injury to sensory neurons; the development of ectopic activity in these neurons is thought to be critical for the induction and maintenance of such pain. Read More