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Acta Derm Venereol 2020 May 25. Epub 2020 May 25.

Department of Oncodermatology, Robert Debré Hospital, avenue du Général Koenig, FR-51092 Reims Cedex, France. E-mail:

Cutaneous involvement in Waldenström's macroglobulinaemia (WM) has been poorly characterized. To describe this involvement, a retrospective study of 19 patients with WM and cutaneous involvement of tumour B-cells was performed. Twelve patients (group 1) had lymphoplasmocytic, non-transformed cutaneous proliferation, while in 7 cases (group 2) cutaneous involvement corresponded to histological transformation. Read More

Int J Surg Pathol 2020 May 27:1066896920917212. Epub 2020 May 27.

National Health Laboratory Service, Tygerberg Hospital, Cape Town, South Africa.

Primary effusion lymphoma is a rare, clinically aggressive large B-cell neoplasm universally associated with human herpesvirus 8 that occurs in the setting of immune compromise. It is classically described as a lymphomatous effusion occurring within body cavities. Recently, however, solid tumor masses, and rarely an intravascular form, have been described. Read More

Acta Derm Venereol 2020 May 18. Epub 2020 May 18.

Department of Dermatology, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, 64239 Tel Aviv, Israel. E-mail:

Indian J Dermatol Venereol Leprol 2020 May 15. Epub 2020 May 15.

Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu, China.

Front Oncol 2020 28;10:662. Epub 2020 Apr 28.

Dermatology Unit, Department of Health Sciences, University of Florence Medical School, Florence, Italy.

Aging Clin Exp Res 2020 May 8. Epub 2020 May 8.

Department of Pharmacy, The Second Hospital of Shanxi Medical University, Shanxi, 030001, China.

Purpose: A few prognostic predicting systems existed for primary cutaneous B-cell lymphoma (PCBCL). However, none of them took age into consideration. We sought to declare the prognostic role of age in PCBCL. Read More

J Tissue Viability 2020 Apr 9. Epub 2020 Apr 9.

University of Health Sciences, Diskapi Yildirim Beyazit Training and Research Hospital, Department of Hematology, Ankara, Turkey.

Diffuse large B cell lymphoma (DLBCL) constitutes the most frequent subtype of all non-Hodgkin's lymphomas. DLBCL is an aggressive disease and extranodal involvement is seen in approximately 30% of patients and most common extranodal sites are gastointestinal tract and skin. Skin involvement may be either primary or secondary. Read More

J Clin Med 2020 Apr 23;9(4). Epub 2020 Apr 23.

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Korea.

Cutaneous lymphoid hyperplasia (CLH) is a heterogeneous type of reactive lymphocytic infiltration resembling cutaneous lymphoma clinically and histopathologically. Few studies describe the relationship between the causative agents and histopathological and immunohistochemical characteristics of CLH. We investigated the clinical and histopathological characteristics of 50 patients with cutaneous CLH and analyzed them according to causative factors and predominant cell types (B or T cells). Read More

Ann Dermatol Venereol 2020 Apr 22. Epub 2020 Apr 22.

Service de dermatologie, université Paris-Diderot-Paris VII, Sorbonne-Paris-Cité, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France. Electronic address:

Introduction: Cutaneous plasmacytosis is a rare skin condition first described in 1976 and it is seen mainly in patients of Asian descent. Patients usually present with multiple reddish-brown macules and nodules chiefly on the trunk and face, with clusters of well-differentiated plasma cells in the dermis. The aetiopathogenesis and nosological features of this entity remain obscure. Read More

Case Rep Dermatol Med 2020 7;2020:8310602. Epub 2020 Apr 7.

University of Massachusetts Medical School, Worcester, MA, USA.

Cutaneous B-cell lymphomas (CBCL) are rare heterogeneous neoplastic diseases composing about 22.5% of all cutaneous lymphomas. These diseases can be divided into primary and secondary cutaneous variants with primary cutaneous B-cell lymphoma (PCBCL) divided into three distinct entities including primary cutaneous marginal zone lymphoma, primary cutaneous follicle center lymphoma, and primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT). Read More

Am J Surg Pathol 2020 Apr 7. Epub 2020 Apr 7.

INSERM U1053 Team 3 Oncogenesis of Cutaneous Lymphomas, Bordeaux Univsersity, Bordeaux.

Primary cutaneous CD4 small/medium T-cell lymphoproliferative disorder (PCSMLPD) is a recently recognized entity in the 2017 World Health Organization (WHO) classification. It belongs to the T-follicular helper (TFH) lymphoproliferations. The clinical, pathologic, and molecular features of this localized disease are underresearched. Read More

Open Med (Wars) 2020 19;15:119-125. Epub 2020 Mar 19.

Pathology Unit, Department of Mental and Physical Health and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy.

Several types of B-cell lymphomas, including both primary cutaneous lymphomas and systemic lymphomas, may affect the skin, with partially overlapping clinical, morphological and immunohistochemical features. Currently, the World Health Organization (WHO) classification of primary cutaneous B-cell lymphomas does not include diffuse large B-cell lymphomas (DLBCL) and considers leg-type DLBCL the only primary cutaneous DLBCL. Here we report the case of a 72-year-old white woman with a primary cutaneous neoplasm comprised of large cells with round nuclei, irregularly clumped chromatin and one or more inconspicuous nucleoli. Read More

Comput Struct Biotechnol J 2020 19;18:668-675. Epub 2020 Mar 19.

Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China.

Microsatellite instability (MSI) is a genomic property of the cancers with defective DNA mismatch repair and is a useful marker for cancer diagnosis and treatment in diverse cancer types. In particular, MSI has been associated with the active immune checkpoint blockade therapy response in cancer. Most of computational methods for predicting MSI are based on DNA sequencing data and a few are based on mRNA expression data. Read More

Cancer Med 2020 Apr 6. Epub 2020 Apr 6.

Department of Radiation Oncology, Gustave Roussy, Université Paris-Saclay, Villejuif, France.

Purpose: In patients with indolent B-cell non-Hodgkin's lymphoma (B-NHL), one course of low-dose radiotherapy (LD-RT) 2 × 2 Gy is emerging as new option of therapy in palliative setting. Efficacy of LD-RT when repeated remains to be determinate. This study aims to assess the efficacy of repeated LD-RT given in patients with indolent B-NHL. Read More

Am J Hematol 2020 Apr 3. Epub 2020 Apr 3.

Department of Hematology, HagaZiekenhuis, The Hague, The Netherlands.

Dermatol Online J 2020 Feb 15;26(2). Epub 2020 Feb 15.

Cedars Dermatology, Cedars Sinai Medical Group, CA.

Thiotepa is a common alkylating agent known to precipitate cutaneous reactions consistent with toxic erythema of chemotherapy, including erythema and hyperpigmentation. Herein, we describe an atypical case of malignant intertrigo involving preferential erythema and desquamation not only of skin folds but also of occluded areas after thiotepa-based conditioning. The diagnosis was complicated by concurrent stomatitis and oral petechiae in the setting of autologous stem cell transplant 11 days prior for diffuse large B-cell lymphoma. Read More

Intern Med 2020 Apr 2. Epub 2020 Apr 2.

Department of General Medicine, National Defense Medical College, Japan.

Yale J Biol Med 2020 Mar 27;93(1):35-40. Epub 2020 Mar 27.

Department of Pathology, Yale University School of Medicine, New Haven, CT.

Intravascular large B-cell lymphoma (IVLBCL) is a rare subset of extranodal non-Hodgkin lymphoma characterized by neoplastic lymphocytes within the lumina of small to medium-sized blood vessels. IVLBCLs are B-cell tumors that can present in essentially any organ system, including the skin. Cutaneous manifestations vary greatly and can mimic other skin disease which may delay diagnosis; in the absence of skin lesions, blind skin biopsies can be utilized for diagnosis. Read More

Bol Med Hosp Infant Mex 2020 ;77(2):90-93

Universidad Veracruzana, Xalapa, Veracruz. México.

Background: Primary cutaneous lymphomas are a rare heterogeneous group of T and B cell skin neoplasms without any evidence of extracutaneous disease at the time of diagnosis, which show considerable differences in histology, phenotype and prognosis.

Case Reports: Five cases of cutaneous lymphomas treated at the Hospital Infantil de México Federico Gómez from 2010 to 2018 are described. The most frequent clinical presentations in these patients were dermatitis, blood scabs, and necrotic ulcers. Read More

Clin Nucl Med 2020 May;45(5):403-404

From the Unité de Médecine Nucléaire, Institut Godinot.

An 86-year-old woman was referred for a rare but aggressive subtype of primary cutaneous lymphoma of the right lower limb: diffuse large B-cell lymphoma leg type. Initial evaluation by whole-body F-FDG PET/CT showed intense hypermetabolic activity of multiple cutaneous and subcutaneous nodules of the distal third of the right leg. Follow-up evaluations by F-FDG PET/CT showed complete response after 4 and 8 cycles of appropriate rituximab combination with polychemotherapy. Read More

Indian J Dermatol 2020 Mar-Apr;65(2):145-147

Department of Otolaryngology-Head and Neck Surgery, The First Hospital of Jilin University, Changchun, Jilin Province, China.

Lymphoma over the nasal dorsum has never been reported. Herein, we report the case of a 74-year-old man who presented with a rapid swelling on the nasal dorsum. A physical examination revealed a firm, immobile, non-tender mass. Read More

Medicine (Baltimore) 2020 Feb;99(9):e18601

Acquired Immunodeficiency Research Center, Isfahan University of Medical Sciences.

Introduction: Primary immunodeficiency diseases (PIDs), a rare group of gene defects with different manifestations, are at great risk of malignancy. The incidence of diffuse large B-cell lymphoma in the sinusoidal tract is quite rare with nasal congestion, stuffiness, and pain in maxillary sinus manifestation. Human serine-threonine kinase 4 (STK4) deficiency affects the immune system with recurrent bacterial and viral infections, mucocutaneous candidiasis, cutaneous warts, skin abscesses, T- and B-cell lymphopenia, and neutropenia. Read More

J Immunol Res 2020 8;2020:1589191. Epub 2020 Feb 8.

Federal University of Rio de Janeiro, Institute of Biological Sciences, Laboratory of Cell Proliferation and Differentiation, Av. Carlos Chagas Filho 373 Room F2-01: 21941-902, Brazil.

Histone Deacetylase- (HDAC-) dependent epigenetic mechanisms have been widely explored in the last decade in different types of malignancies in preclinical studies. This effort led to the discovery and development of a range of new HDAC inhibitors (iHDAC) with different chemical properties and selective abilities. In fact, hematological malignancies were the first ones to have new iHDACs approved for clinical use, such as Vorinostat and Romidepsin for cutaneous T cell lymphoma and panobinostat for multiple myeloma. Read More

J Cutan Pathol 2020 Feb 22. Epub 2020 Feb 22.

Department of Dermatology, University of Minnesota, Minneapolis, Minnesota, USA.

Mycosis fungoides (MF) is an indolent, uncommon, non-Hodgkin T-cell lymphoma of the skin. It classically presents with patches, plaques, and tumors and may rarely show spread to internal organs or bone marrow. Up to 7. Read More

J Dermatol Sci 2020 Mar 25;97(3):187-193. Epub 2020 Jan 25.

Department of Dermatology, Kyoto Prefectural University of Medicine, Kyoto, Japan.

Background: The types of cutaneous lymphoma (CL) and their incidences can vary among geographic areas or ethnic groups.

Objective: This study aimed to investigate the incidence of various CL types in Japan using epidemiological data from a nationwide registration system for CL.

Methods: A questionnaire was sent to participating hospitals, all of which had been approved to conduct residency programs for board-certified dermatologists by the Japanese Dermatological Association. Read More

Diagn Cytopathol 2020 May 3;48(5):479-482. Epub 2020 Feb 3.

Department of Pathology, Government Medical College and Hospital, Chandigarh, India.

Primary adrenal lymphoma (PAL) is an extremely rare condition. We describe here, a case of bilateral adrenal lymphoma in a 62-year-old man. He later developed subcutaneous masses on the hand and the leg. Read More

PLoS One 2020 24;15(1):e0228046. Epub 2020 Jan 24.

Department of Dermatology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Background: While mycosis fungoides (MF) and Sézary syndrome (SS) are the most common cutaneous lymphomas (CLs), there is limited data about non-MF/SS CLs.

Objective: We aimed to evaluate clinical characteristics of non-MF/SS CLs.

Methods: A retrospective analysis evaluated patients with non-MF/SS CLs covering a period of 17 years. Read More

Australas J Dermatol 2020 May 16;61(2):e226-e228. Epub 2020 Jan 16.

Dermatology Department, Cutaneous Lymphoma Clinic, Medical School, "A. Sygros" Hospital for Skin Diseases, National & Kapodistrian University of Athens, Athens, Greece.

The role of tumor infiltrating immune cells in cancer development and progression is a new, promising field in oncological research. An increasing number of novel anti-cancer agents are focussing on the tumor microenvironment. Various studies have reported on B-cell infiltrates in mycosis fungoides (MF), but despite the substantial volume of interesting findings, solid evidence regarding their specific role in cancer is still vague. Read More

Pathologe 2020 Feb;41(1):79-94

Universitätshautklinik Würzburg, Universitätsklinikum Würzburg, Josef-Schneider-Str. 2, 97080, Würzburg, Deutschland.

Cutaneous lymphomas comprise different subgroups with distinct biological behavior. Mycosis fungoides, the most common cutaneous lymphoma, presents with patches, plaques, tumors and erythroderma. Therapeutic options depend on stage and comprise local skin-directed treatment in early stages, while later stages and Sézary syndrome require systemic therapies including bexarotene, interferon or brentuximab vedotin. Read More

Vet Dermatol 2020 Jun 12;31(3):250-e56. Epub 2020 Jan 12.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University California, Davis, One Garrod Drive, Davis, CA, 95616, USA.

Background: Reports of dermal sclerosis in dogs include scleroderma or morphea of unknown cause, cicatricial alopecia and congenital/hereditary fibrosis.

Clinical Summary: A 12-year-old, male castrated chihuahua-mix dog was evaluated for skin lesions of unknown duration. The dog had severe alopecia, skin thickening and marked peripheral lymphadenopathy. Read More

Semin Cancer Biol 2020 Jan 3. Epub 2020 Jan 3.

Department of Surgery, Yale School of Medicine, CT, United States. Electronic address:

Advances in immunotherapy, most notably antibodies targeting the inhibitory immune receptors cytotoxic T-lymphocyte associated protein 4 (CTLA-4/CD152), programmed death protein 1 (PD-1/CD279) and programmed death-ligand 1 (PD-L1/B7H1/CD274) have become effective standard therapies in advanced malignancies including melanoma,1-4 merkel cell carcinoma5, urological cancers6-8, non-small cell lung cancer9-11, mis-match repair (MMR) deficient tumors12, and Hodgkin lymphoma with response rates ranging from 25 to 60% in the first and second line settings13,14. FDA approval has also been given for treatment for hepatocellular carcinoma, gastric cancer, triple negative breast cancer, cervical and head and neck cancers with response rates closer to 15 %15. Additionally, some clinical efficacy has been observed in ovarian cancer, mesothelioma, prostate cancer, diffuse large B cell lymphoma, follicular lymphoma, and both cutaneous and peripheral T-cell lymphoma. Read More

JAAD Case Rep 2020 Jan 27;6(1):60-62. Epub 2019 Dec 27.

Department of Dermatology, University of Texas Medical Branch, Galveston, Texas.

Eur J Dermatol 2019 12;29(6):666-667

Division of Hematology/Oncology, Department of Medicine, Kameda Medical Center, Kamogawa, Japan.

Clin Case Rep 2019 Dec 6;7(12):2429-2432. Epub 2019 Nov 6.

Department of Geriatrics Universitary Hospital Gregorio Marañón Madrid Spain.

Intravascular B-cell Lymphoma is a rare lymphoproliferative disorder with a none specific clinical presentation. The association of cutaneous telangiectasia-like lesions and elevated inflammatory markers should be guaranteed a skin biopsy. Read More

Int Wound J 2020 Apr 29;17(2):514-515. Epub 2019 Dec 29.

Department of Clinical Medicine and Surgery, Section of Dermatology, University of Naples Federico II, Naples, Italy.

Open Access Maced J Med Sci 2019 Sep 30;7(18):3006-3008. Epub 2019 Jun 30.

Department of Dermatology, University of Rome "G. Marconi", Rome, Italy.

Background: Cutaneous B-cell lymphomas represent about 25% of all cutaneous lymphomas. Peripheral diffuse large B-cell lymphoma of the leg type is the most aggressive subtype seen mainly in elderly patients. Treatment is not standardised. Read More

Skin Appendage Disord 2019 Nov 2;5(6):379-385. Epub 2019 Jul 2.

Dr. Phillip Frost Department of Dermatology and Cutaneous Surgery, University of Miami Hospital, University of Miami Miller School of Medicine, Miami, Florida, USA.

Primary cutaneous follicle center lymphoma (PCFCL) is a rare type of indolent, low-grade cutaneous B-cell lymphoma with an excellent prognosis. It usually presents with erythematous nodules and plaques on the head, neck, or back. The diagnosis is primarily based on histopathology, immunohistochemistry, and molecular studies. Read More

An Bras Dermatol 2019 Nov - Dec;94(6):759-761. Epub 2019 Oct 26.

Pathology Service, Hospital Virgen de la Salud, Complejo Hospitalario de Toledo, Toledo, Spain.

Virchows Arch 2020 May 28;476(5):683-699. Epub 2019 Nov 28.

Department of Pathology, Queen Elizabeth University Hospital, Level 3, Laboratory Medicine Building, 1345 Govan Rd, Glasgow, G51 4TF, Scotland.

The major aim of Session 1 of the 2018 European Association of Hematopathology/Society for Hematopathology Workshop was to collect examples of cutaneous lymphomas, excluding mycosis fungoides/Sezary syndrome, as defined in the current WHO classification of tumours of the haemetopoietic and lymphoid tissues. Overall 42 cases were submitted. These were considered in four main categories: primary cutaneous B cell lymphomas (12 cases), primary cutaneous T cell lymphomas/lymphoproliferations with CD8+/cytotoxic phenotype (12 cases), primary cutaneous CD30-positive lymphoproliferative disorders (15 cases) and primary cutaneous T cell lymphomas/leukaemias with CD4+ phenotype (4 cases). Read More

Am J Surg Pathol 2020 Mar;44(3):424-427

INSERM U1053, Team 3 Oncogenesis of Cutaneous Lymphomas, University of Bordeaux, Bordeaux, France.

Strahlenther Onkol 2020 Feb 22;196(2):126-131. Epub 2019 Nov 22.

Department of Radiation Oncology, University Hospital Muenster, Albert-Schweitzer-Campus 1, Building A1, 48149, Muenster, Germany.

Objective: Radiotherapy (RT) has an established role in the curative treatment of indolent primary cutaneous B‑cell lymphoma (PCBCL). With the role of low-dose regimens such as 2 × 2 Gy being uncertain, we compared conventional-dose RT to a low-dose approach and investigated outcome and toxicities.

Materials And Methods: We retrospectively reviewed the medical records of 26 patients with 44 cutaneous lesions treated at our institution between 2007 and 2017, comprising 22 marginal zone lymphoma (PCMZL) lesions and 22 follicle center lymphoma (PCFCL) lesions. Read More

Hematol Oncol Clin North Am 2020 Feb;34(1):189-203

Department of Therapeutic Radiology, Smilow Cancer Center, Yale University, 35 Park Street, Lower Lobby, New Haven, CT 06510, USA.

Radiation plays an important role in the management of a variety of skin cancers. This article discusses the role of radiation in the treatment of cutaneous squamous cell carcinoma, basal cell carcinoma, Merkel cell carcinoma, cutaneous T-cell lymphoma, and B-cell lymphomas. Read More

Dermatol Online J 2019 Sep 15;25(9). Epub 2019 Sep 15.

Oregon Health and Science University, Portland, OR.

A 55-year-old man with relapsing-remitting multiple sclerosis on fingolimod presented to the dermatology clinic with skin lesions on the left temple and cheek. Histopathology showed a diffuse infiltrate of enlarged, atypical lymphocytes throughout the dermis with an overlying grenz zone and a subpopulation of scattered smaller lymphocytes and plasma cells. Epstein-Barr virus-encoded RNA in situ hybridization stain was positive. Read More

Pathology 2020 Jan 15;52(1):53-67. Epub 2019 Nov 15.

Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA. Electronic address:

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma, representing approximately one-third of all cases worldwide. In the World Health Organization (WHO) classification of lymphomas, most cases of DLBCL are designated as not otherwise specified (NOS). About 20% of cases, however, are designated as specific variants of DLBCL. Read More

J Eur Acad Dermatol Venereol 2020 Feb 5;34(2):260-266. Epub 2019 Dec 5.

Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.

Background: Lymphomatoid papulosis (LyP) can be associated with other haematological malignancies (HM), but reported percentages vary from 20% to over 50%.

Objective: To evaluate the frequency and prognostic significance of associated HM and non-HM in LyP patients.

Methods: In this multicentre cohort study, the complete Dutch LyP population was included from the Dutch Cutaneous Lymphoma Registry between 1985 and 2018. Read More

Int Immunopharmacol 2019 Dec 6;77:105999. Epub 2019 Nov 6.

Department of Haematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China; Malignant Lymphoma Diagnosis and Therapy Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China. Electronic address:

Background: Recently, unprecedented clinical efficacy was observed during treatment of many solid tumors because of the introduction of programmed cell death 1 (PD-1)/programmed cell death 1 ligand 1 (PD-L1) immune checkpoint inhibitors. Preliminary clinical data indicates that checkpoint inhibition also represents a promising therapeutic strategy for certain lymphoid malignancies. However, PD-1/PD-L1 expression levels on neoplastic cells and in the tumor microenvironment vary among subtypes and their prognostic implications remain uncertain. Read More

J Cutan Pathol 2020 Apr 27;47(4):394-397. Epub 2019 Nov 27.

Department of Dermatology, Mayo Clinic, Jacksonville, Florida.

Primary cutaneous follicle center cell lymphoma is the most prevalent type of primary cutaneous B-cell lymphoma and usually portends a favorable prognosis. Typically, the diagnosis can be rendered based on characteristic histopathologic features and immunohistochemical profile. Rarely, a diagnostically challenging variant with a predominant spindle morphology mimicking other malignant spindle cell neoplasms may be encountered. Read More