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BMJ Case Rep 2022 May 6;15(5). Epub 2022 May 6.

Department of Diagnostic Pathology, Shimada General Medical Center, Shimada, Shizuoka, Japan.

A woman in her 80s reported of generalised pruritus, which was treated with phototherapy and steroid administration. Two months after onset, lymph node biopsy revealed CD4+ angioimmunoblastic T-cell lymphoma with systemic superficial nodal involvement. Intractable prurigo was judged as T-cell lymphoma related. Read More

Dermatol Online J 2021 Dec 15;27(12). Epub 2021 Dec 15.

Departamento de Docencia e Investigacion, Escuela de Medicina, Universidad Internacional del Ecuador, Quito, Ecuador Servicio de Patologia, Hospital Metropolitano, Quito, Ecuador.

Primary cutaneous diffuse large B-cell lymphoma, leg type is a rare entity accounting for 4% of all primary cutaneous lymphomas whose clinical presentation encompasses a range of possibilities. COVID-19 has caused a delay in diagnosis of malignant neoplasms and consequently, this has resulted in poorer prognoses. A 62-year-old woman presented with two smooth-surfaced, mobile, well-circumscribed, oval, skin-colored nodules approximately one-cm in diameter with nonerythematous borders on the lower third of the left leg. Read More

Cancer Manag Res 2022 21;14:1507-1514. Epub 2022 Apr 21.

Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, People's Republic of China.

Philadelphia chromosome positive B cell lymphoblastic lymphoma (Ph+ B-LBL) is an extremely rare disease. We report a 27-year-old patient diagnosed with primary testicular and cutaneous Ph+ B-LBL without bone marrow involvement. The CCCG-LBL-2016 regimen (https://clinicaltrials. Read More

J Am Acad Dermatol 2022 Apr 24. Epub 2022 Apr 24.

Department of Dermatology, Yale School of Medicine, New Haven, CT. Electronic address:

PLoS One 2022 22;17(4):e0266978. Epub 2022 Apr 22.

Tumor Biology and Tumor Bank Department, University Hospital of Bordeaux, Bordeaux, France.

Primary cutaneous large B-cell lymphomas (PCLBCL) represent a diagnostic challenge because they are classified as PCLBCL, leg type (PCLBCL, LT) or primary cutaneous follicle centre lymphoma, large cell (PCFCL, LC), which differ by prognosis and therapeutic requirement. Unclassified cases with discordant clinical presentations, morphologies, and immunophenotypes may be classified into the not otherwise specified (PCLBCL, NOS) category based on ancillary molecular analyses. Cell-of-origin profiling as germinal centre (GC) type or non-GC type by immunohistochemistry is not considered reproducible because of variable CD10 expression. Read More

JAAD Case Rep 2022 May 10;23:73-75. Epub 2022 Mar 10.

Department of Dermatology, Duke University Medical Center, Durham, North Carolina.

BMJ Case Rep 2022 Mar 30;15(3). Epub 2022 Mar 30.

Department of Geriatrics Neurosciences and Orthopedics, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Roma, Lazio, Italy.

Primary lymphoma of the peripheral nerve is very rare and occurs most frequently in sciatic nerves. We describe the first patient reported in literature with a primary lymphoma in a pure sensory peripheral nerve of the upper limb. A woman in her 40s, with painful swelling and dysaesthesias in her left forearm in the past 3 months, was presented at our unit. Read More

Acta Derm Venereol 2022 04 4;102:adv00688. Epub 2022 Apr 4.

Centre Hospitalier de Valence, Service de dermatologie, Valence, France.

Cell Metab 2022 Apr 15;34(4):615-633.e8. Epub 2022 Mar 15.

Department of Innovative Medical Science, Tokai University School of Medicine, Isehara, Japan; Division of Hematological Malignancy, Institute of Medical Sciences, Tokai University, Isehara, Japan. Electronic address:

Extracellular vesicles (EVs) including exosomes act as intercellular communicators by transferring protein and microRNA cargoes, yet the role of EV lipids remains unclear. Here, we show that the pro-tumorigenic action of lymphoma-derived EVs is augmented via secreted phospholipase A (sPLA)-driven lipid metabolism. Hydrolysis of EV phospholipids by group X sPLA, which was induced in macrophages of Epstein-Barr virus (EBV) lymphoma, increased the production of fatty acids, lysophospholipids, and their metabolites. Read More

Neuropathology 2022 Mar 9. Epub 2022 Mar 9.

Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

Lymphomatosis cerebri (LC) is a rare variant of primary central nervous system lymphoma (PCNSL). It is characterized by diffuse infiltration of atypical lymphoid cells with no mass formation and little or no contrast enhancement on magnetic resonance imaging (MRI). Interestingly, some lymphoma cells form characteristic spindle shapes; these cells are found in some variants of malignant lymphoma, such as primary cutaneous follicle center lymphoma, but they have not been reported in PCNSL or LC. Read More

Case Rep Gastrointest Med 2022 27;2022:2687291. Epub 2022 Feb 27.

Pathology Department, Thingangyun General Hospital, Yangon, Myanmar.

Diffuse large B cell lymphoma (DLBCL) is the histological subtype of non-Hodgkin's lymphoma, representing approximately 30%. The most common primary extranodal sites of DLBCL are the gastrointestinal (GI) tract, the head and neck, and the skin/soft tissue. We report a case of DLBCL with cutaneous involvement presenting with skin nodules and GI manifestations such as obstructive jaundice and upper GI bleeding. Read More

J Am Vet Med Assoc 2022 Mar 8:1-10. Epub 2022 Mar 8.

Department of Pathology, Microbiology and Immunology, School of Veterinary Medicine, University of California-Davis, Davis, CA.

Objective: To determine the clinical and pathological findings of rabbits diagnosed with lymphoma.

Animals: 16 rabbits.

Procedures: The medical and pathology records database of the Veterinary Medical Teaching Hospital at the University of California, Davis was searched for rabbits diagnosed with lymphoma from 1996 to 2019. Read More

JAMA Dermatol 2022 Apr;158(4):414-425

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Rockville, Maryland.

Importance: Nonkeratinocyte skin cancers are an important cause of morbidity and mortality for immunosuppressed solid organ transplant recipients (SOTRs), but the spectrum of disease and risk factor characteristics are unknown.

Objective: To characterize the spectrum of disease and risk factors for common and rare nonkeratinocyte skin cancers in SOTRs.

Design, Setting, And Participants: This population-based cohort study included 444 497 SOTRs who underwent a transplant in the US between January 1, 1987, and December 31, 2017, using linked data from the national transplant registry and 32 cancer registries. Read More

J Dermatol 2022 Mar 1. Epub 2022 Mar 1.

Department of Dermatology, Sapporo Medical University School of Medicine, Sapporo, Japan.

J Investig Med High Impact Case Rep 2022 Jan-Dec;10:23247096211063066

The University of Toledo, OH, USA.

Malignancies have been associated with paraneoplastic syndromes, such as dermatomyositis. Subacute cutaneous lupus erythematosus (SCLE) can occur due to a wide array of cancers. Paraneoplastic SCLE obeys McLean's criteria and often regresses after the underlying malignancy has been treated appropriately. Read More

Dermatol Pract Concept 2022 Feb 1;12(1):e2022006. Epub 2022 Jan 1.

Dermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, Italy.

Pathol Res Pract 2022 Apr 22;232:153812. Epub 2022 Feb 22.

Department of Advanced Biomedical Sciences, Pathology Section, University of Naples "Federico II", Naples, Italy. Electronic address:

Aims: To assess the prognostic value of Bcl2 and Bcl6 in primary cutaneous diffuse large B-cell lymphoma (pcDLBCL), through a systematic review and meta-analysis.

Methods: Electronic databases were searched from their inception to April 2021 for studies reporting Bcl2 and Bcl6 expression and survival outcomes in pcDLBCL series. Kaplan-Meier and Cox regression survival analyses with hazard ratio calculation were performed for overall survival (OS), with a significant p-value< 0. Read More

Diagnostics (Basel) 2022 Jan 24;12(2). Epub 2022 Jan 24.

Haematopathology Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, 40138 Bologna, Italy.

The spectrum of cutaneous CD30-positive lymphoproliferative disorders encompasses both inflammatory and neoplastic conditions. CD30+ Hodgkin and Reed-Sternberg-like cells have been occasionally reported in primary cutaneous marginal zone lymphoma, where they are thought to represent a side neoplastic component within a dominant background of lymphomatous small B cells. Herein, we describe the histological and molecular findings of three cases of primary cutaneous marginal zone lymphomas with CD30+ H/RS cells, in which next-generation sequencing analysis revealed the clonal population to consist in less than 5% of the cutaneous B-cell infiltrate, providing a thought-provoking focus on a possible main role for CD30+ cells in primary cutaneous marginal zone lymphoproliferations. Read More

Acta Derm Venereol 2022 04 4;102:adv00687. Epub 2022 Apr 4.

Dermatology Clinic, Department of Medical Sciences University of Turin, Via Cherasco 23, IT-10121 Turin, Italy.

Acta Derm Venereol 2022 Mar 14;102:adv00668. Epub 2022 Mar 14.

Department of Dermatology and Venerology, Peking University First Hospital, Beijing 100034, China.

Pathol Res Pract 2022 Mar 16;231:153804. Epub 2022 Feb 16.

University of Salerno, Department of Medicine and Surgery, "Scuola Medica Salernitana", Salerno, Italy.

Objective: to assess whether immunohistochemical (IHC) algorithms used to classify the cell of origin (COO) of nodal Diffuse Large B-cell lymphoma (nDLBCL) in Germinal Center type (GCB) and non-GCB subtypes may be applied to Primary Cutaneous B-cell lymphoma (PCBCL) too, and which of these algorithms performs better on PCBCL.

Design: Retrospective case control study.

Setting: Pathology Department of the University Hospital "San Giovanni di Dio e Ruggi d'Aragona" Salerno, Italy. Read More

Am J Dermatopathol 2022 Mar;44(3):179-182

Department of Dermatology, First Affiliated Hospital, Zhengzhou University, Zhengzhou, China.

Abstract: Primary cutaneous lymphoma occurring at the site of lymphedema is a rare complication. A total of 13 cases of primary cutaneous lymphoma associated with chronic lymphedema have been reported in international studies. We reported a case of cutaneous diffuse large B-cell lymphoma (DLBCL) (leg type) secondary to chronic lymphedema of the lower limbs. Read More

J Eur Acad Dermatol Venereol 2022 Jun 10;36(6):836-845. Epub 2022 Mar 10.

Dermatologikum Hamburg, Hamburg, Germany.

Background: The role of Borrelia in the development of skin lymphomas has been under discussion for decades. A similar association has been shown for Helicobacter pylori and gastric lymphomas (MALT type). Nevertheless, few molecular studies investigated Borrelia in skin lymphomas and the results are controversial. Read More

J Cutan Med Surg 2022 Feb 15:12034754221077694. Epub 2022 Feb 15.

Department of Pathology, Sainte-Justine University Hospital Center, University of Montreal, Montreal, Quebec, Canada.

Background: Cutaneous hematologic malignancies are rare in children, and the literature about them is still sparse.

Objective: The purpose of our study was to report our experience with pediatric cases of cutaneous hematologic disorders and describe their clinical and histological features.

Methods: Data were retrospectively collected from the histopathologic database of the CHU Sainte-Justine, University of Montreal, Montreal, Canada. Read More

Dermatology 2022 Feb 14:1-10. Epub 2022 Feb 14.

Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.

Background: Primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL, LT) is an aggressive lymphoma variant. Anthracycline-based chemotherapy with rituximab is recommended as first-line treatment. Radiotherapy (RT) has been considered as a therapeutic option for local disease control in patients with solitary or localized lesions. Read More

Cureus 2022 Jan 10;14(1):e21083. Epub 2022 Jan 10.

Dermatology, University of California, Davis Medical Center, Sacramento, USA.

Tattoos, a common form of body adornment, have been associated with numerous cutaneous complications. These include not only benign neoplasms and malignant tumors but also lymphoid conditions occurring within the tattoo. Tattoo-associated dermatomyofibroma, epidermoid inclusion cyst, hemangioma, lipoma, milia, and pilomatricoma are benign lesions that have each only been described in one individual. Read More

Medicine (Baltimore) 2022 Feb;101(5):e28721

Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.

Rationale: Cytomegalovirus (CMV) disease is relatively uncommon in nontransplant hematological patients. Moreover, cutaneous manifestations of CMV diseases have scarcely been reported and are probably under-recognized.

Patient Concerns: We describe a patient with large B-cell lymphoma who developed a band-form, erythematous lesion over his left abdomen soon after the second course of rituximab, cyclophosphamide, doxorubicin, vincristine, prednisolone chemotherapy. Read More

Pediatr Dermatol 2022 Jan;39(1):e8-e10

Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.