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    12716 results match your criteria Cushing Syndrome

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    Familial Forms of Cushing Syndrome in Primary Pigmented Nodular Adrenocortical Disease Presenting with Short Stature and Insidious Symptoms: A Clinical Series.
    Horm Res Paediatr 2018 Jun 15:1-11. Epub 2018 Jun 15.
    Pediatric Endocrinology Unit, Cliniques universitaires Saint Luc, Université Catholique de Louvain, Brussels, Belgium.
    Cushing syndrome (CS) is a rare disease in children, frequently associated with subtle or periodic symptoms that may delay its diagnosis. Weight gain and growth failure, the hallmarks of hypercortisolism in pediatrics, may be inconsistent, especially in ACTH-independent forms of CS. Primary pigmented nodular adrenocortical disease (PPNAD) is the rarest form of ACTH-independent CS, and can be associated with endocrine and nonendocrine tumors, forming the Carney complex (CNC). Read More

    Adipokine and cytokine levels in non-functioning adrenal incidentalomas (NFAI).
    Endocr J 2018 Jun 5. Epub 2018 Jun 5.
    Department of Endocrinology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland.
    Due to the fact that overweight or obesity is accompanied by hormonally active adrenal tumors: Cushing Syndrome-(CS) and Subclinical Cushing Syndrome (SCS), it is of high interest the correlation between different adipokines and cytokines secreted by adipose tissue, with metabolic disorders and hormonal activity in this group. Even in non-functioning adrenal incidentalomas (NFAI) elevated risk for cardiovascular disease and metabolic syndrome was demonstrated. The aim of the study was to investigate plasma adiponectin, leptin, resistin, tumor necrosis factor α (TNFα), interleukin 6 (IL6) and monocyte chemoattractant protein 1 (MCP1) levels in patients with NFAIs and healthy subjects. Read More

    Surviving ectopic Cushing's syndrome: Quality of life, cardiovascular and metabolic outcomes in comparison to Cushing's disease during long-term follow-up.
    Eur J Endocrinol 2018 Jun 6. Epub 2018 Jun 6.
    M Reincke, Ludwig-Maximilians-Universität München, Medizinische Klinik Innenstadt, Munich, Germany
    OBJECTIVE Aim of our study was to analyze long-term outcome of patients with the ectopic Cushing's syndrome (ECS) compared to patients with Cushing's disease (CD) regarding cardiovascular, metabolic, musculoskeletal and psychiatric co-morbidities. DESIGN Cross-sectional study in patients with ECS and CD in two German academic tertiary-care centers. METHODS Standardized clinical follow-up examination was performed including health-related quality of life (QoL) in 21 ECS patients in long-term remission (≥ 18 months since successful surgery). Read More

    Design and synthesis of functionalized piperazin-1yl-(E)-stilbenes as inhibitors of 17α-hydroxylase-C17,20-lyase (Cyp17).
    Bioorg Med Chem Lett 2018 Jul 22;28(13):2270-2274. Epub 2018 May 22.
    GVK Biosciences Private Limited, Plot 28A, IDA Nacharam, Hyderabad 500076, India.
    The synthesis of steroid hormones is critical to human physiology and improper regulation of either the synthesis of these key molecules or activation of the associated receptors can lead to disease states. This has led to intense interest in developing compounds capable of modulating the synthesis of steroid hormones. Compounds capable of inhibiting Cyp19 (Aromatase), a key enzyme in the synthesis of estrogens, have been successfully employed as breast cancer therapies, while inhibitors of Cyp17 (17α-hydroxylase-17,20-lyase), a key enzyme in the synthesis of glucocorticoids, mineralocorticoids and steroidal sex hormones, are a key component of prostate cancer therapy. Read More

    Inflammatory myopathy in the context of an unusual overlapping laminopathy.
    Arch Endocrinol Metab 2018 May 17. Epub 2018 May 17.
    IDIS, CIMUS, University of Santiago de Compostela, Spain.
    Laminopathies are genetic disorders associated with alterations in nuclear envelope proteins, known as lamins. The LMNA gene encodes lamins A and C, and LMNA mutations have been linked to diseases involving fat (type 2 familial partial lipodystrophy [FPLD2]), muscle (type 2 Emery-Dreifuss muscular dystrophy [EDMD2], type 1B limb-girdle muscular dystrophy [LGMD1B], and dilated cardiomyopathy), nerves (type 2B1 Charcot-Marie-Tooth disease), and premature aging syndromes. Moreover, overlapping syndromes have been reported. Read More

    [Cyclic Cushings syndrome: a case study and overview].
    Vnitr Lek 2018 ;64(4):450-456
    Cushings syndrome and especially Cushing´s disease represent diagnostically and therapeutically complicated medical situations. In some patients, cyclic changes in cortisol production additionally hamper the diagnosis in terms of source identification and management of hormone overproduction. It may not be clear, whether the patient is cured or not even years after the treatment. Read More

    Assessment of vertebral microarchitecture in overt and mild Cushing's syndrome using trabecular bone score.
    Clin Endocrinol (Oxf) 2018 May 21. Epub 2018 May 21.
    Department of Endocrinology, Diabetes and Nutrition, University Hospital of Bordeaux, USN Haut Leveque, Bordeaux, France.
    Objective: Osteoporotic fractures associated with Cushing's syndrome (CS) may occur despite normal bone mineral density (BMD). Few studies have described alterations in vertebral microarchitecture in glucocorticoid-treated patients and during CS. Trabecular bone score (TBS) estimates trabecular microarchitecture from dual-energy X-ray absorptiometry acquisitions. Read More

    [Hypertension associated with paraparesis of the lower limbs revealing an adrenal adenoma].
    Ann Cardiol Angeiol (Paris) 2018 Jun 17;67(3):226-229. Epub 2018 May 17.
    Service de médecine interne, CHU Tidjani Demerdji, Université Abou Bekr Belkaid, Tlemcen 13000, Algérie. Electronic address:
    Cushing's syndrome is a rare cause of high blood pressure. The originally adrenal cause is found in 15% of cases. We describe the case of a patient with hypertension associated with paraparesis of the lower limbs revealing a Cushing syndrome due to a left adrenal adenoma. Read More

    Two types of ectopic Cushing syndrome or a continuum? Review.
    Pituitary 2018 May 15. Epub 2018 May 15.
    Department Endocrinology, Hospital Universitario de la Princesa, Madrid, Spain.
    Background: Two types of ectopic Cushing syndrome (ECS) are described: ECS associated with aggressive neoplasms, and ECS with indolent and occult tumors, however, there is a lack of studies that thoroughly review their characteristics.

    Methods: A systematic review was carried out on PUBMED of all the papers about the ECS, in order to better define the types of this subcategory of Cushing's syndrome, highlighting the differential aspects between these subgroups.

    Results: It was found that in 50% of cases the prototypic "aggressive" ECS is caused by small cell lung carcinomas (SCLC). Read More

    Cushing's Syndrome in Pediatrics: An Update.
    Endocrinol Metab Clin North Am 2018 Jun;47(2):451-462
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1E-3330, MSC1103, Bethesda, MD 20892, USA.
    Cushing syndrome (CS) is a multisystem disorder resulting from the prolonged exposure to excess glucocorticoids. In children, CS most commonly results from the exogenous administration of steroids and the typical presentation is height deceleration concomitant with weight gain. Endogenous and ectopic causes are rare. Read More

    Diagnosis of Cushing's Syndrome in the Modern Era.
    Endocrinol Metab Clin North Am 2018 Jun;47(2):259-273
    Diabetes, Endocrine, and Obesity Branch, The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Building 10, CRC, 1 East, Room 1-3140, 10 Center Drive, MSC 1109, Bethesda, MD 20892-1109, USA. Electronic address:
    Four challenges complicate the evaluation for Cushing syndrome. These challenges include increasing global prevalence of obesity and diabetes; increasing use of exogenous glucocorticoids, which cause a Cushing syndrome phenotype; the confusion caused by nonpathologic hypercortisolism not associated with Cushing syndrome, which may present with symptoms consistent with Cushing syndrome; and difficulty identifying pathologic hypercortisolism when it is extremely mild or cyclic or in renal failure, incidental adrenal masses, and pregnancy. Careful choice of screening tests, consideration of confounding conditions, and repeated testing when the results are ambiguous improve the accuracy of diagnosis. Read More

    Etomidate in the control of severe Cushing's syndrome by neuroendocrine carcinoma.
    Clin Case Rep 2018 May 12;6(5):851-854. Epub 2018 Mar 12.
    Department of Endocrinology and Metabolism Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán Vasco de Quiroga 15 Tlalpan, México City 14000 México.
    Etomidate is a very effective drug in severe Cushing's syndrome that is refractory to ketoconazol. Control of the serum cortisol levels in ectopic Cushing's syndrome can be obtained with infusion rates much lower than those used in anesthesia, without respiratory side effects. Read More

    Genomic insights into Cushing syndrome.
    Ann Endocrinol (Paris) 2018 Jun 4;79(3):119-122. Epub 2018 May 4.
    Service d'endocrinologie, centre de référence des maladies rares de la surrénale, Assistance publique-Hôpitaux de Paris, hôpital Cochin, 75014 Paris, France; Inserm U1016, CNRS 8104, institut Cochin, université Paris Descartes, 75014 Paris, France. Electronic address:
    In the setting of Cushing syndrome, genomic analyses can be performed either in tumors responsible for endogenous Cushing, or in patients exposed to glucocorticoid excess. Genomics of tumors identified several new genes - including ZNRF3 in adrenocortical carcinomas, PRKACA in cortisol-producing adrenal adenomas, ARMC5 in primary macronodular adrenal hyperplasia and USP8 in pituitary corticotroph adenomas. These genes shed new lights on the mechanisms responsible for these tumors. Read More

    The difficulties of pseudo-Cushing's syndrome (or "non-neoplastic hypercortisolism").
    Ann Endocrinol (Paris) 2018 Jun 30;79(3):138-145. Epub 2018 Apr 30.
    Service d'endocrinologie, faculté de médecine, unité mixte Inserm-CEA-UJF U1036 CEA, université Grenoble-Alpes, centre hospitalier universitaire Grenoble-Alpes, 38043 Grenoble, France. Electronic address:
    Pseudo-Cushing's syndrome covers different pathological conditions responsible for mild-to-moderate ACTH-dependent hypercortisolism, related not to an ACTH-secreting tumor but rather to CRH and/or AVP hypothalamic secretion through activation of various neural pathways, in patients generally displaying excess central adiposity. It is better termed "non-neoplastic hypercortisolism" (NNH). The main conditions implicated in NNH comprise: neuropsychiatric disorder, alcohol abuse, insulin-resistant obesity, polycystic ovary syndrome, and end-stage kidney disease. Read More

    Clinical Investigation of Adrenal Incidentalomas in Japanese Patients of the Fukuoka Region with Updated Diagnostic Criteria for Sub-clinical Cushing's Syndrome.
    Intern Med 2018 Apr 27. Epub 2018 Apr 27.
    Department of Endocrinology and Diabetes Mellitus, Fukuoka University Chikushi Hospital, Japan.
    Objectives We retrospectively investigated the clinical and endocrinological characteristics of adrenal incidentalomas. Methods We studied 61 patients who had been diagnosed with adrenal incidentalomas and had undergone detailed clinical and endocrinological evaluations while hospitalized. We used common criteria to diagnose the functional tumors, but for sub-clinical Cushing's syndrome, we used an updated set of diagnosis criteria: serum cortisol ≥1. Read More

    Cystic tumors of the pituitary infundibulum: seminal autopsy specimens (1899 to 1904) that allowed clinical-pathological craniopharyngioma characterization.
    Pituitary 2018 Apr 21. Epub 2018 Apr 21.
    Department of Pathology and Clinical Bacteriology, Jakob Erdheim Institute, Vienna, Austria.
    A heterogeneous group of epithelial cystic tumors developed at the infundibulum and the third ventricle disconcerted pathologists at the dawn of the twentieth century. Very little was known at that time about the physiological role played by the pituitary gland, and there was almost complete ignorance regarding the function of the hypothalamus. Acromegaly, or enlargement of acral body parts, described in 1886 by Pierre Marie, was the only disease linked to primary hypertrophies of the pituitary gland, known as "pituitary strumas". Read More

    Aberrant G-protein coupled hormone receptor in adrenal diseases.
    Best Pract Res Clin Endocrinol Metab 2018 Apr 31;32(2):165-187. Epub 2018 Jan 31.
    Division of Endocrinology, Department of Medicine and Research Center, Centre hospitalier de l'Université de Montréal (CHUM), Montréal, Québec, Canada. Electronic address:
    The regulation of cortisol or aldosterone production when ACTH of pituitary origin or the renin-angiotensin systems are suppressed in primary adrenal Cushing's syndrome or in primary aldosteronism is exerted by diverse genetic and molecular mechanisms. In addition to recently identified mutations in various genes implicated in the cyclic AMP or ion channel pathways, steroidogenesis is not really autonomous as it is frequently regulated by the aberrant adrenocortical expression of diverse hormone receptors, particularly G-protein coupled hormone receptors (GPCR) which can substitute for the normal function of ACTH or angiotensin-II. In addition, paracrine or autocrine production of ligands for the aberrant GPCR such as ACTH or serotonin is found in some adrenal tumors or hyperplasias and participates in a complex regulatory loop causing steroid excess. Read More

    Adrenocortical development: Lessons from mouse models.
    Ann Endocrinol (Paris) 2018 Jun 16;79(3):95-97. Epub 2018 Apr 16.
    GReD, CNRS, Inserm, université Clermont-Auvergne, 63001 Clermont-Ferrand, France. Electronic address:
    The adrenocortical gland undergoes structural and functional remodelling in the fetal and postnatal periods. After birth, the fetal zone of the gland undergoes rapid involution in favor of the definitive cortex, which reaches maturity with the emergence of the zona reticularis(zR) at the adrenarche. The mechanisms underlying the adrenarche, the process leading to pre-puberty elevation of plasma androgens in higher primates, remain unknown, largely due to lack of any experimental model. Read More

    Quality of life in patients with adrenal disease: A systematic review.
    Clin Endocrinol (Oxf) 2018 Apr 19. Epub 2018 Apr 19.
    Centre for Endocrinology, Barts and the London School of Medicine & Dentistry, William Harvey Research Institute, Queen Mary University of London, London, UK.
    Background: Evaluating the patient with adrenal disease is challenging due to the lack of precise clinical and biochemical parameters for disease control. Quality of life (QOL) evaluation aims to measure the patient's subjective experience.

    Objective: To describe how QOL is defined and measured in adrenal disease, critically appraise the use of QOL tools in published literature, discuss the implications of these findings and provide direction for further research in this field. Read More

    Activating PRKACB somatic mutation in cortisol-producing adenomas.
    JCI Insight 2018 Apr 19;3(8). Epub 2018 Apr 19.
    Cochin Institute, Paris Descartes University, CNRS (UMR 8104)/Inserm (U1016), Paris, France.
    Mutations in the gene encoding the protein kinase A (PKA) catalytic subunit α have been found to be responsible for cortisol-producing adenomas (CPAs). In this study, we identified by whole-exome sequencing the somatic mutation p.S54L in the PRKACB gene, encoding the catalytic subunit β (Cβ) of PKA, in a CPA from a patient with severe Cushing syndrome. Read More

    Non-adenomatous pituitary tumours mimicking functioning pituitary adenomas.
    Br J Neurosurg 2018 Apr 18:1-5. Epub 2018 Apr 18.
    b Key Laboratory of Pituitary Adenoma in Guangdong Province, Department of Neurosurgery , First Affiliated Hospital, SunYat-sen University , Guangzhou , China.
    Objective: Pituicytomas and granular cell tumours (GCTs) of the neurohypophysis are considered non-adenomatous neoplasms in the sellar region. The association between hormone hypersecretion and the tumours is seldom discussed and unclear. Therefore, we attempt to investigate this association based on our experience and a review of the literature. Read More

    MECHANISMS IN ENDOCRINOLOGY: A sense of time of the glucocorticoid circadian clock: from the ontogeny to the diagnosis of Cushing's syndrome.
    Eur J Endocrinol 2018 Jul 16;179(1):R1-R18. Epub 2018 Apr 16.
    Departments of Internal MedicineRibeirao Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil.
    The circadian rhythm of glucocorticoids has long been recognised within the last 75 years. Since the beginning, researchers have sought to identify basic mechanisms underlying the origin and emergence of the corticosteroid circadian rhythmicity among mammals. Accordingly, Young, Hall and Rosbash, laureates of the 2017 Nobel Prize in Physiology or Medicine, as well as Takahashi's group among others, have characterised the molecular cogwheels of the circadian system, describing interlocking transcription/translation feedback loops essential for normal circadian rhythms. Read More

    Do the diagnostic criteria for subclinical hypercortisolism exist?
    Ann Endocrinol (Paris) 2018 Jun 13;79(3):146-148. Epub 2018 Apr 13.
    Department of endocrinology, diabetes and nutrition, CHU de Bordeaux, hopital Haut-Lévêque, 33604 Pessac, France. Electronic address:
    "Subclinical hypercortisolism" (SH) refers to a condition associated with a mild chronic increase in cortisol secretion. By definition, patients with SH do not exhibit specific symptoms of overt Cushing's syndrome (such as purple striae, easy bruising, proximal muscle weakness), SH has been preferred to "subclinical Cushing's syndrome", a semantic ambiguity since Cushing's syndrome is, by definition, a set of symptoms; and to the term "preclinical Cushing syndrome" because the progression toward overt clinical hypercortisolism is very rare. However, SH still is misnomer as a number of studies suggest that this condition may induce long-term non-specific adverse conditions related to the mild cortisol excess (i. Read More

    Ectopic Cushing syndrome: Report of 9 cases.
    Endocrinol Diabetes Nutr 2018 May 11;65(5):255-264. Epub 2018 Apr 11.
    Servicio de Endocrinología y Nutrición, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, España.
    Introduction: Ectopic Cushing's syndrome (ECS) is a rare condition caused by ACTH secretion by extrapituitary tumors. Its low frequency makes it difficult to acquire experience in its management. The aim of this study was to describe patients with ECS seen at the endocrinology department of a tertiary hospital over 15 years. Read More

    Harvey Cushing's management of neurogenic thoracic outlet syndrome.
    J Neurosurg 2018 Apr 13:1-4. Epub 2018 Apr 13.
    Department of Neurosurgery, Mayo Clinic, Jacksonville, Florida.
    Harvey Cushing is widely regarded as one of the forefathers of neurosurgery, and is primarily associated with his work on intracranial pathology. However, he had a clinical and academic interest in peripheral nerve surgery. Through the courtesy of the Alan Mason Chesney Medical Archives, the surgical records of the Johns Hopkins Hospital from 1896 to 1912 were reviewed. Read More

    Contralateral adrenal width predicts the duration of prolonged post-surgical steroid replacement for subclinical Cushing syndrome.
    Int J Urol 2018 Jun 12;25(6):583-588. Epub 2018 Apr 12.
    Department of Urology, Chiba University Graduate School of Medicine, Chiba, Japan.
    Objectives: To identify pre-treatment factors affecting the duration of post-surgical steroid replacement in patients undergoing adrenalectomy for subclinical Cushing syndrome.

    Methods: The present retrospective analysis included 64 patients who underwent unilateral laparoscopic adrenalectomy for subclinical Cushing syndrome. Adrenal tumor and contralateral adrenal sizes together with various clinical factors were studied in association with the duration of post-surgical steroid replacement. Read More

    An update on Cushing syndrome in pediatrics.
    Ann Endocrinol (Paris) 2018 Jun 9;79(3):125-131. Epub 2018 Apr 9.
    Section on Endocrinology and Genetics (SEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), 10, Center Drive, CRC, Rm 1E-3216, 20892-1862 Bethesda, MD, USA. Electronic address:
    Cushing syndrome (CS) in childhood results mostly from the exogenous administration of glucocorticoids; endogenous CS is a rare disease. The latter is the main reason pediatric patients with CS escape diagnosis for too long. Other barriers to optimal care of a pediatric patient with CS include improper following of the proper sequence of testing for diagnosing CS, which stems from lack of understanding of pathophysiology of the hypothalamic-pituitary-adrenal axis; lack of access to proper (i. Read More

    Rebound thymic hyperplasia after adrenalectomy in a patient with Cushing syndrome caused by adrenocortical adenoma: A case report.
    Medicine (Baltimore) 2018 Apr;97(15):e0367
    Department of Pediatrics, Chonbuk National University Medical School.
    Rationale: The development of rebound thymic hyperplasia (RTH) has been reported in patients who have recovered from stressful conditions such as surgery and steroid therapy. We report a case of RTH following the resolution of hypercortisolism after adrenalectomy for the treatment of adrenocortical adenoma in a patient with Cushing syndrome.

    Patient Concerns: A 5-month-old female infant with a history of overeating, hirsutism, and excessive weight gain for the previous 2 months was referred to the hospital. Read More

    Kinetics and inhibition studies of the L205R mutant of cAMP-dependent protein kinase involved in Cushing's syndrome.
    FEBS Open Bio 2018 Apr 11;8(4):606-613. Epub 2018 Mar 11.
    Department of Medicinal ChemistrySchool of PharmacyVirginia Commonwealth UniversityRichmondVAUSA.
    Overproduction of cortisol by the hypothalamus-pituitary-adrenal hormone system results in the clinical disorder known as Cushing's syndrome. Genomics studies have identified a key mutation (L205R) in the α-isoform of the catalytic subunit of cAMP-dependent protein kinase (PKACα) in adrenal adenomas of patients with adrenocorticotropic hormone-independent Cushing's syndrome. Here, we conducted kinetics and inhibition studies on the L205R-PKACα mutant. Read More

    Quality of Life in Cushing's disease: A long term issue?
    Ann Endocrinol (Paris) 2018 Jun 4;79(3):132-137. Epub 2018 Apr 4.
    Endocrinology/Medicine Department, Research Center for Pituitary Diseases, Hospital Sant Pau, IIB-Sant Pau, Universitat Autònoma de Barcelona (UAB), Pare Claret 167, 08025 Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER, Unidad 747), ISCIII, Spain. Electronic address:
    The purpose of this review is to describe how quality of life (QoL) is impaired in patients with hypercortisolism due to Cushing's syndrome of any aetiology, including pituitary-dependent Cushing's disease. It is worse in active disease, but improvement after successful therapy is often incomplete, due to persistent physical and psychological co-morbidities, even years after endocrine "cure". Physical symptoms like extreme fatigability, central obesity with limb atrophy, hypertension, fractures, and different skin abnormalities severely impair the affected patients' everyday life. Read More

    Emberger syndrome: A rare association with hearing loss.
    Int J Pediatr Otorhinolaryngol 2018 May 7;108:82-84. Epub 2018 Feb 7.
    Department of Otolaryngology, Head and Neck Surgery, Hospital for Sick Children, Toronto, ON Canada; Department of Otolaryngology, Head and Neck Surgery, University of Toronto, Toronto, ON Canada; Archie's Cochlear Implant Laboratory, Hospital for Sick Children, Toronto, ON Canada. Electronic address:
    Emberger Syndrome (ES) is a rare genetic disorder characterized by lymphedema and myelodysplasia. It is also associated with hearing loss. The genetic mutations associated with ES are not part of the comprehensive 80 gene next generation sequencing (NGS) panel. Read More

    The Many Faces of Primary Aldosteronism and Cushing Syndrome: A Reflection of Adrenocortical Tumor Heterogeneity.
    Front Med (Lausanne) 2018 12;5:54. Epub 2018 Mar 12.
    Department of Pathology, University Health Network, Toronto, ON, Canada.
    Adrenal cortical tumors constitute a heterogeneous group of neoplasms with distinct clinical, morphological, and molecular features. Recent discoveries of specific genotype-phenotype correlations in adrenal cortical adenomas have transformed our understanding of their respective endocrine syndromes. Indeed, a proportion of patients with primary aldosteronism are now known to harbor adrenal cortical adenomas with heterogeneous molecular alterations (, and ) involving the calcium/calmodulin kinase signaling pathway. Read More

    Bone Health in Adrenal Disorders.
    Endocrinol Metab (Seoul) 2018 Mar;33(1):1-8
    Division of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
    Secondary osteoporosis resulting from specific clinical disorders may be potentially reversible, and thus continuous efforts to find and adequately treat the secondary causes of skeletal fragility are critical to ameliorate fracture risk and to avoid unnecessary treatment with anti-osteoporotic drugs. Among the hyperfunctional adrenal masses, Cushing's syndrome, pheochromocytoma, and primary aldosteronism are receiving particularly great attention due to their high morbidity and mortality mainly by increasing cardiovascular risk. Interestingly, there is accumulating experimental and clinical evidence that adrenal hormones may have direct detrimental effects on bone metabolism as well. Read More

    Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN.
    Clin Endocrinol (Oxf) 2018 Jun 16;88(6):787-798. Epub 2018 Apr 16.
    Institute of Medicine at Sahlgrenska Academy, University of Gothenburg and the Department of Endocrinology, Sahlgrenska University Hospital, Gothenburg, Sweden.
    Objective: Hypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS).

    Methods: Data from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. Read More

    Exogenous Cushing syndrome from an unexpected source of systemic steroids.
    Pediatr Dermatol 2018 May 25;35(3):e196-e197. Epub 2018 Mar 25.
    School of Medicine, Georgetown University, Washington, DC, USA.
    A 12-year-old Hispanic boy with chronic atopic dermatitis and cushingoid features presented to our institution. He was being treated with an unknown quantity of oral prednisolone 15 mg/5 mL, equivalent to 70 mg/m /d of oral prednisone, purchased over the counter in El Salvador. Systemic corticosteroids are not recommended for chronic therapy of atopic dermatitis because of their significant adverse effects. Read More

    Case-series of paraneoplastic Cushing syndrome in small-cell lung cancer.
    Endocrinol Diabetes Metab Case Rep 2018 8;2018. Epub 2018 Mar 8.
    Department of Endocrinology, Mount Lebanon Hospital, Beirut, Lebanon.
    The objective of this study is to report three cases of paraneoplastic or ectopic Cushing syndrome, which is a rare phenomenon of the adrenocorticotropic hormone (ACTH)-dependent Cushing syndrome. Three cases are reported in respect of clinical presentation, diagnosis and treatment in addition to relevant literature review. The results showed that ectopic ACTH secretion can be associated with different types of neoplasm most common of which are bronchial carcinoid tumors, which are slow-growing, well-differentiated neoplasms with a favorable prognosis and small-cell lung cancer, which are poorly differentiated tumors with a poor outcome. Read More

    Secreting ectopic adrenal adenoma: A rare condition to be aware of.
    Ann Endocrinol (Paris) 2018 Apr 7;79(2):75-81. Epub 2018 Mar 7.
    Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong, University School of Medicine, Xi'an, Shannxi 710061, PR China. Electronic address:
    Ectopic adrenal adenoma causing chronic Cushing's syndrome (CS) is a rare phenomenon. Diagnosis is usually made years after disease onset because of the insidious nature of the ectopic adrenal gland and because it overlaps with common symptoms, such as overweight and hypertension, in the general population (Kreitschmann-Andermahr et al., 2015). Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Management of Cushing's syndrome during pregnancy: solved and unsolved questions.
    Eur J Endocrinol 2018 Jun 9;178(6):R259-R266. Epub 2018 Mar 9.
    Aix-Marseille UniversitéInstitut National de la Santé et de la Recherche Médicale (INSERM), U1251, Marseille Medical Genetics, Marseille, France.
    With fewer than 200 reported cases, Cushing's syndrome (CS) in pregnancy remains a diagnostic and therapeutic challenge. In normal pregnancies, misleading signs may be observed such as striae or hypokalemia, while plasma cortisol and urinary free cortisol may rise up to 2- to 3-fold. While the dexamethasone suppression test is difficult to use, reference values for salivary cortisol appear valid. Read More

    [Homeostasis and Disorder of Musculoskeletal System.Influence of steroid therapy on muscuoskeletal system.]
    Clin Calcium 2018;28(3):402-409
    Division of Rheumatology, Center for Antibody and Vaccine Therapy/Department of Rheumatology & Allergy, IMSUT Hospital, Institute of Medical Science, University of Tokyo, Japan.
    Muscle atrophy occurs when glucocorticoid steroids are administered in pharmacological doses or in Cushing syndrome, and such pathological condition is termed as steroid myopathy. Its molecular mechanism is clarified from the study of the gene expression regulation mechanism mediated by steroid receptors in skeletal muscle, progressing to translational research and also addressing the mechanism by which steroids participate in the regulation of whole body energy metabolism via skeletal muscle. Read More

    Case Of Iatrogenic Cushing's Syndrome By Topical Triamcinolone.
    J Ayub Med Coll Abbottabad 2018 Jan-Mar;30(1):121-123
    Rush University, Chicago, Illinois-USA.
    Cushing's syndrome is a collection of signs and symptoms due to hypercortisolism. Prolong use of topical steroid may cause this syndrome and suppression of hypothalamic and pituitary function, however such events are more common with oral and parenteral route. There are very few cases of Cushing's syndrome with a topical application amongst which triamcinolone is the rarest drug. Read More

    Evaluation of individual low-dose dexamethasone suppression test patterns in naturally occurring hyperadrenocorticism in dogs.
    J Vet Intern Med 2018 May 2;32(3):967-977. Epub 2018 Mar 2.
    University College Dublin Veterinary Hospital, University College Dublin, Belfield, Dublin, Ireland.
    Background: Dogs with hyperadrenocorticism (HAC) may be more mildly affected at the time of diagnosis today, which could influence the prevalence of associated clinical and clinicopathological abnormalities and diagnostic test performance. Different low-dose dexamethasone suppression test (LDDST) result patterns have not been evaluated individually.

    Objectives: To assess the current features of HAC and evaluate if the diagnostic test performance of individual LDDST result patterns differ. Read More

    DIAGNOSIS OF ENDOCRINE DISEASE: The role of the desmopressin test in the diagnosis and follow-up of Cushing's syndrome.
    Eur J Endocrinol 2018 May 22;178(5):R201-R214. Epub 2018 Feb 22.
    Department of EndocrinologyDiabetes and Metabolism, Evangelismos Hospital, Athens, Greece
    Desmopressin is a vasopressin analogue selective for type 2 vasopressin receptors that mediate renal water retention. In contrast to the native hormone arginine vasopressin, a well-known ACTH secretagogue, desmopressin, exerts minimal or no activity on ACTH excretion. However, in a substantial proportion of patients with ACTH-dependent Cushing's syndrome (CS), desmopressin elicits an ACTH and cortisol response, which contrasts with the minimal responses obtained in healthy subjects. Read More

    Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France.
    Eur J Endocrinol 2018 May 22;178(5):447-458. Epub 2018 Feb 22.
    Department of EndocrinologyAix Marseille Universite, CNRS UMR7286, Assistance Publique-Hopitaux de Marseille, La Conception Hospital, Marseille, France.
    Objective: Ketoconazole (KTZ) is one of few available treatments for Cushing's syndrome (CS). Although KTZ has been associated with severe hepatotoxicity, little information is available about hepatic safety in CS. The aim of this study was to document changes in liver function in patients with CS treated with KTZ. Read More

    MANAGEMENT OF ENDOCRINE DISEASE: Can we cure Cushing's disease? A personal view.
    Eur J Endocrinol 2018 May 21;178(5):R183-R200. Epub 2018 Feb 21.
    Service des Maladies Endocriniennes et MétaboliquesCentre de Référence des Maladies Rares de la Surrénale, Hôpital Cochin, Faculté de Médecine Paris Descartes, Université Paris 5, Paris, France
    One of today's challenges in endocrinology is the treatment of Cushing's disease: Although pituitary surgery has the potential to 'cure' the patient and restore a completely normal pituitary adrenal axis, there are immediate failures and late recurrences that will ultimately require alternate therapeutic approaches. Their high number is in direct correlation with their serious limitations and they all appear to be 'default options'. This 'personal view' tries to shed some light on the inescapable difficulties of the current treatments of Cushing's disease and to provide some optimistic view for the future where the pituitary adenoma should be the 'reasonable obsession' of a successful therapeutist. Read More

    Incidence of Autoimmune and Related Disorders After Resolution of Endogenous Cushing Syndrome in Children.
    Horm Metab Res 2018 Apr 19;50(4):290-295. Epub 2018 Feb 19.
    Section on Endocrinology and Genetics, Eunice Kennedy Shriver Institute of Child Health and Human Development (NICHD), National Institutes of Health, Bethesda, Maryland, USA.
    Glucocorticoids are widely used for immunosuppression in autoimmune diseases. After the resolution of hypercortisolemia, the immune system recovers allowing for autoimmune diseases to manifest. Here we investigated the presence of autoimmune and related diseases that developed after cure of endogenous Cushing syndrome (CS) in children. Read More

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