12,861 results match your criteria Cushing Syndrome


Local hyperthermia cleared multifarious viral warts in a patient with Cushing's syndrome.

Dermatol Ther 2019 Jan 11:e12815. Epub 2019 Jan 11.

NHC/Ministry of Education/Liaoning Province Key Laboratory of Immunodermatology(China Medical University)The First Hospital of China Medical University, No.155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province,, P.R.China.

A female Cushing's syndrome patient had been suffering from extensive viral warts for months. She was diagnosed with flat warts, common warts and plantar warts. The plantar warts on her right foot were initially treated using local hyperthermia at 44°C for 30 minutes according to a defined protocol, followed by treatment targeting a common wart on her left thumb. Read More

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http://dx.doi.org/10.1111/dth.12815DOI Listing
January 2019
1 Read

Three Novel MEN1 Variants in AIP-Negative Familial Isolated Pituitary Adenoma Patients.

Pathobiology 2019 Jan 10:1-7. Epub 2019 Jan 10.

Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Turkey.

Objectives: Pituitary adenomas (PAs) may rarely occur in well-defined hereditary conditions, like multiple endocrine neoplasia type 1 (MEN1) syndrome and familial isolated pituitary adenoma (FIPA) associated with germline mutations in MEN1 and AIP, respectively. This study aimed to assess MEN1 genetic abnormalities in AIP mutation-negative FIPA patients, not associated with MEN1 components.

Methods: Among 20 patients evaluated in 13 FIPA families, 12 were previously reported as AIP mutation-negative. Read More

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http://dx.doi.org/10.1159/000495252DOI Listing
January 2019

Hepatic Lesions Associated with McCune Albright Syndrome.

J Pediatr Gastroenterol Nutr 2019 Jan 4. Epub 2019 Jan 4.

Division of Gastroenterology, Hepatology and Nutrition, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA, USA.

McCune Albright Syndrome (MAS) results from a GNAS gene mutation. It is associated with café-au-lait macules, fibrous dysplasia, and several endocrinopathies to include gonadotropin-independent precocious puberty, growth hormone excess, Cushing syndrome, thyroid disease, and renal phosphate wasting. It is recognised to be a rare cause of neonatal cholestasis. Read More

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http://dx.doi.org/10.1097/MPG.0000000000002266DOI Listing
January 2019

Optical Imaging Technology: A Useful Tool to Identify Remission in Cushing Disease After Surgery.

Horm Metab Res 2019 Jan 2. Epub 2019 Jan 2.

Section on Endocrinology and Genetics Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, Maryland, USA.

We recently reported the use of optical imaging technology to quantify facial plethora in endogenous Cushing syndrome (CS). In the present study, we studied a larger cohort of patients with Cushing disease (CD) and examined water content fraction as well as blood volume fraction as bio-optic markers for determining the efficacy of this methodology as a predictor of lasting remission after surgery for CS. We imaged 49 patients before and after transsphenoidal surgery (TSS) for Cushing disease (CD); 22 patients were also seen at 3-6 months, and 13 patients 12 months post-operatively. Read More

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http://dx.doi.org/10.1055/a-0801-8917DOI Listing
January 2019
2 Reads

Unilateral Adrenalectomy Could Be a Valid Option for Primary Nodular Adrenal Disease: Evidence From Twins.

J Endocr Soc 2019 Jan 24;3(1):129-134. Epub 2018 Oct 24.

Division of Endocrinology, Hôpital Erasme, Brussels, Belgium.

Primary pigmented nodular adrenal disease (PPNAD) accounts for <1% of ACTH-independent Cushing syndrome. We describe the case of twin female patients with PPNAD who both had sustainable disease control after unilateral adrenalectomy, which corroborates current evidence in favor of unilateral adrenalectomy for a subset of patients with PPNAD. Patient A presented with a 10-kg weight gain over the past year and facial plethora. Read More

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http://dx.doi.org/10.1210/js.2018-00261DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302904PMC
January 2019

Avascular necrosis of the femoral head: An exceptional complication of cushing's disease.

Ann Afr Med 2018 Oct-Dec;17(4):225-227

Department of Endocrinology and Diabetology, University Hospital of Fez, Fez, Morocco.

Avascular necrosis (AVN) of the femoral head is a well-recognized complication of steroid treatment. Exogenous glucocorticoids' administration and alcoholism are the most common nontraumatic etiologies. AVN secondary to endogenous hypercortisolism (HC) is rare; very few case reports are available on this complication. Read More

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http://dx.doi.org/10.4103/aam.aam_75_17DOI Listing
December 2018
4 Reads

Development of Iatrogenic Cushing Syndrome After Peri-articular Glucocorticoid Injection in an Human Immunodeficiency Virus Patient on Protease Inhibitor Therapy.

J Clin Rheumatol 2018 Dec 5. Epub 2018 Dec 5.

Rheumatology Department Ramón y Cajal University, Hospital Madrid, Spain Rheumatology Department Ramón y Cajal University Hospital Madrid, Spain. Infectious Diseases Department Ramón y Cajal University Hospital Madrid, Spain.

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http://dx.doi.org/10.1097/RHU.0000000000000940DOI Listing
December 2018

Peripheral primitive neuroectodermal tumor associated with paraneoplastic Cushing's syndrome: The rare case.

Ann Med Surg (Lond) 2019 Jan 29;37:21-24. Epub 2018 Nov 29.

Iran University of Medical Science, Tehran, Iran.

Introduction: Primitive neuroectodermal tumors (PNET) form a group of tumors defined by their appearance that are thought to develop from primitive (undifferentiated) nerve cells in the brain. They are rare tumors and their incidence is not well defined.

Case Presentation: An 18-month-old male presenting with typical Cushingoid appearance (moon face, central obesity, hirsutism and growth arrest) was admitted for evaluation of endocrine problems. Read More

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http://dx.doi.org/10.1016/j.amsu.2018.11.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287080PMC
January 2019

Drug design strategies for Cushing's syndrome.

Expert Opin Drug Discov 2018 Dec 20:1-9. Epub 2018 Dec 20.

a Institute of Bioorganic Chemistry of the National Academy of Science of Belarus , Minsk , Republic of Belarus.

Introduction: Cushing's syndrome (CS) is a metabolic disorder caused by chronic hypercortisolism. CS is associated with cardiovascular, metabolic, skeletal and psychological dysfunctions and can be fatal if left untreated. The first-line treatment for all forms of CS is a surgery. Read More

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http://dx.doi.org/10.1080/17460441.2019.1559146DOI Listing
December 2018
3 Reads

[Cushing's syndrome during pregnancy : diagnostic and therapeutic difficulties].

Rev Med Liege 2018 Dec;73(12):603-609

Service d`Endocrinologie, CHU de Liège, Liège, Belgique.

Cushing's syndrome (CS), which is often associated with infertility, exceptionally occurs in pregnancy, and markedly increases maternal and fetal morbidity and mortality. Gestational CS may be challenging. Indeed, symptoms of hypercorticism may overlap with physiological hyperactivity of the hypothalamus-pituitary-adrenal axis in normal pregnancy. Read More

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December 2018
1 Read

A challenging case of laparoscopic synchronous bilateral adrenalectomy for Cushing's disease. Case report.

Ann Med Surg (Lond) 2018 Dec 8;36:261-263. Epub 2018 Sep 8.

University-Hospital of Parma, Department of Urology, Via Gramsci 14, Parma, 43126, Italy.

Introduction: Laparoscopic adrenalectomy is a treatment option in patients with Cushing's syndrome. Preoperative comorbities as well as surgical and anesthesiological difficulties can make the procedure challenging.

Presentation Of The Case: We present the case of a 53-year-old obese man diagnosed with Cushing's syndrome, also suffering from other endocrine pathologies, neurofibromatosis type 2, cardiomiopathy with severe hypertrophy and diastolic dysfunction, deep vein thrombosis (DVT) and obstructive sleep apnea syndrome (OSAS). Read More

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http://dx.doi.org/10.1016/j.amsu.2018.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6287572PMC
December 2018

Cholestatic drug induced liver injury caused by mifepristone.

Hepatology 2018 Dec 18. Epub 2018 Dec 18.

Department of Internal Medicine, Medical University of South Carolina, 96 Jonathan Lucas Street, Suite 803.

Mifepristone (also known as RU-486, which has been used historically with misoprostol to induce abortion), is now being used to inhibit excess cortisol activity in adults with endogenous Cushing's Syndrome. To our knowledge, no prior reports of liver injury associated with its use exist. This article is protected by copyright. Read More

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http://doi.wiley.com/10.1002/hep.30465
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http://dx.doi.org/10.1002/hep.30465DOI Listing
December 2018
4 Reads

Continuous Etomidate Infusion for the Management of Severe Cushing Syndrome: Validation of a Standard Protocol.

J Endocr Soc 2019 Jan 26;3(1):1-12. Epub 2018 Oct 26.

Endocrine Center and Clinics, Froedtert Hospital and the Medical College of Wisconsin, Menomonee Falls, Wisconsin.

Objective: Demonstrate the safety and efficacy of a standardized intravenous etomidate infusion protocol in normalizing cortisol levels in patients with severe and life-threatening hypercortisolism.

Methods: A retrospective case series of seven patients representing nine episodes of severe hypercortisolism at two large academic medical centers was conducted. Patients were included in this series if they received an etomidate infusion for the treatment of severe and life-threatening hypercortisolism. Read More

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http://dx.doi.org/10.1210/js.2018-00269DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6291660PMC
January 2019

An ectopic adrenocortical adenoma in renal hilum presenting with Cushing's syndrome: A case report and literature review.

Medicine (Baltimore) 2018 Dec;97(50):e13322

Department of Endocrinology, Peking University First Hospital, China.

Rationale: Ectopic adrenal tissue is the adrenal rests along the path from gonads to adrenal glands during embryogenesis. Ectopic adrenocortical adenoma is a rare disease represented with over-production of cortisol by the ectopic adrenocortical tissue.

Patient Concerns: An 18-year-old Chinese female patient was presented with weight-gain for 6 months. Read More

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http://dx.doi.org/10.1097/MD.0000000000013322DOI Listing
December 2018

An update on the genetics of benign pituitary adenomas in children and adolescents.

Curr Opin Endocr Metab Res 2018 Aug 24;1:19-24. Epub 2018 Apr 24.

Section on Endocrinology & Genetics (SEGEN), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892, USA.

Pituitary adenomas in children and adolescents are rare tumors that often result from a tumor predisposition syndrome. Several inherited causes for pituitary adenomas have been identified in the last few years, including multiple endocrine neoplasia type 1 and 4, Carney's complex, Tuberous sclerosis, DICER1 syndrome, neurofibromatosis type 1, McCune Albright syndrome, familial isolated pituitary adenoma, and pituitary adenoma association due to defects in succinate dehydrogenase genes. Recently, our group discovered X-linked acrogigantism (X-LAG), a new pediatric disorder that is caused by an Xq26. Read More

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http://dx.doi.org/10.1016/j.coemr.2018.04.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6289528PMC

Concurrent pituitary and adrenocortical lesions on computed tomography imaging in dogs with spontaneous hypercortisolism.

J Vet Intern Med 2018 Dec 11. Epub 2018 Dec 11.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.

Background: Spontaneous hypercortisolism or Cushing's syndrome in dogs is either pituitary or adrenal dependent, but concurrent pituitary and adrenal hypercortisolism also has been reported.

Objective: To determine how often concurrent pituitary and adrenal lesions are present in dogs with spontaneous hypercortisolism.

Animals: Two hundred one client-owned dogs with spontaneous hypercortisolism. Read More

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http://dx.doi.org/10.1111/jvim.15378DOI Listing
December 2018
1 Read

The coexistence of Cushing syndrome and gynecomastia as the manifestations of adrenocortical carcinoma.

Kaohsiung J Med Sci 2018 12 4;34(12):705-706. Epub 2018 Jul 4.

Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Excellence Center in Diabetes, Hormones and Metabolism, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. Electronic address:

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http://dx.doi.org/10.1016/j.kjms.2018.06.004DOI Listing
December 2018
1 Read

Carcinoid tumors of the thymus and Cushing's syndrome: Clinicopathologic features and current best evidence regarding the cell of origin of these unusual neoplasms.

Ann Diagn Pathol 2018 Nov 22;38:71-79. Epub 2018 Nov 22.

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, United States of America.

It is uncertain whether thymic neuroendocrine tumors (NET) associated with Cushing's syndrome (CS) produce corticotropin-releasing hormone (CRH) and adrenocorticotropin hormone (ACTH) and whether the thymus contains ACTH and/or CRH cells that could originate NET. The clinicopathologic features of 5 typical (TC) and 6 atypical carcinoids (ATC), 10 additional non-neoplastic thymi, 6 adrenal glands with bilateral nodular hyperplasia and 8 adrenal cortical adenomas were reviewed. Representative slides were immunostained for ACTH and CRH. Read More

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http://dx.doi.org/10.1016/j.anndiagpath.2018.11.006DOI Listing
November 2018
2 Reads

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma.

N Engl J Med 2019 01 1;380(1):45-56. Epub 2018 Dec 1.

From the Lymphoma Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia (S.J.S.); the Hematopoietic Cellular Therapy Program, University of Chicago Medicine, Chicago (M.R.B.); Peter MacCallum Cancer Centre, St. Vincent's Hospital and University of Melbourne, Melbourne, VIC (C.S.T.), and the Royal Prince Alfred Hospital and Department of Medicine, University of Sydney, Sydney (P.J.H.) - both in Australia; Winship Cancer Institute of Emory University, Bone Marrow and Stem Cell Transplant Center, Atlanta (E.K.W.); the Department of Hematology and Oncology, University Hospital of Cologne, Cologne (P.B.), and the Würzburg University Medical Center, Center for Allogeneic Stem Cell Transplantation, Würzburg (S.M.) - both in Germany; the Division of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Cancer Center, Kansas City (J.P.M.); the Department of Medicine I, Division of Hematology and Hemostaseology, Medical University of Vienna, Vienna (U.J.); James Cancer Hospital and Solove Research Institute, Ohio State University Comprehensive Cancer Center, Columbus (S.J.); the Department of Hematology and Blood and Marrow Transplant, University of California, San Francisco, Helen Diller Family Comprehensive Cancer Center, San Francisco (C.A.); the Department of Lymphoma and Myeloma, Division of Cancer Medicine, University of Texas M.D. Anderson Cancer Center, Houston (J.R.W.); Maisonneuve-Rosemont Hospital, University of Montreal, Montreal (I.F.), and the Juravinski Hospital and Cancer Centre, McMaster University, Hamilton, ON (S.R.F.) - both in Canada; the Division of Hematology, Oncology, and Transplantation, University of Minnesota, Minneapolis (V.B.); Karolinska Institutet and University Hospital, Department of Laboratory Medicine/Department of Cell Therapy and Allogeneic Stem Cell Transplantation, Stockholm (S.M.); University of Michigan Comprehensive Cancer Center, Ann Arbor (J.M.M.); the Department of Oncology, Oslo University Hospital, Oslo (H.H.); Novartis Pharma, Basel, Switzerland (S.P., O.A.); Novartis Pharmaceuticals (L.B.P., J.C.) and Novartis Institutes for BioMedical Research (R.A.), East Hanover, NJ; the Department of Hematology, Hospices Civils de Lyon, Université de Lyon, Lyon, France (G.S.); and the Center for Hematologic Malignancies, Oregon Health and Science University Knight Cancer Institute, Portland (R.T.M.).

Background: Patients with diffuse large B-cell lymphoma that is refractory to primary and second-line therapies or that has relapsed after stem-cell transplantation have a poor prognosis. The chimeric antigen receptor (CAR) T-cell therapy tisagenlecleucel targets and eliminates CD19-expressing B cells and showed efficacy against B-cell lymphomas in a single-center, phase 2a study.

Methods: We conducted an international, phase 2, pivotal study of centrally manufactured tisagenlecleucel involving adult patients with relapsed or refractory diffuse large B-cell lymphoma who were ineligible for or had disease progression after autologous hematopoietic stem-cell transplantation. Read More

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http://www.nejm.org/doi/10.1056/NEJMoa1804980
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http://dx.doi.org/10.1056/NEJMoa1804980DOI Listing
January 2019
9 Reads

[Pediatric pancreoblastoma with Cushing syndrome].

Authors:
L Song G Y Wang H Pan

Zhonghua Er Ke Za Zhi 2018 Dec;56(12):952-953

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http://dx.doi.org/10.3760/cma.j.issn.0578-1310.2018.12.013DOI Listing
December 2018
2 Reads

Neurosurgical treatment of Cushing disease in pediatric patients: case series and review of literature.

Childs Nerv Syst 2018 Nov 28. Epub 2018 Nov 28.

Pediatric Endocrinology and Adolescent Divisions, Department of Pediatrics, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey.

Aim: Pituitary adenomas are rare in childhood in contrast with adults. Adrenocorticotropic hormone (ACTH)-secreting adenomas account for Cushing's disease (CD) which is the most common form of ACTH-dependent Cushing's syndrome (CS). Treatment strategies are generally based on data of adult CD patients, although some difficulties and differences exist in pediatric patients. Read More

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http://dx.doi.org/10.1007/s00381-018-4013-5DOI Listing
November 2018
1 Read

Hormonal aggressiveness according to the expression of cellular markers in corticotroph adenomas.

Endocrine 2018 Nov 24. Epub 2018 Nov 24.

Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea.

Purpose: The molecular mechanisms underlying tumor growth in Cushing's disease (CD) still remain a challenge. Moreover, clinical manifestations of CD may vary depending on hormonal activity; however, factors involved in the hormonal aggressiveness of adrenocorticotropic hormone (ACTH)-secreting pituitary tumors have not been fully clarified. We investigated the association between the expression of cellular markers regarding pituitary tumor progression and initial or postoperative hormone levels in patients with CD. Read More

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http://dx.doi.org/10.1007/s12020-018-1815-xDOI Listing
November 2018

An update on adrenal endocrinology: significant discoveries in the last 10 years and where the field is heading in the next decade.

Hormones (Athens) 2018 Dec 19;17(4):479-490. Epub 2018 Nov 19.

Section on Endocrinology and Genetics & Inter-Institute Endocrinology Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), NIH-Clinical Research Center, 10 Center Drive, Building 10, Room 1-3330, MSC1103, Bethesda, MD, 20892, USA.

The last 10 years have produced an amazing number of significant discoveries in the field of adrenal endocrinology. The development of the adrenal gland was linked to specific molecules. Cortisol-producing lesions were associated mostly with defects of the cyclic AMP (cAMP) signaling pathway, whereas aldosterone-producing lesions were found to be the result of defects in aldosterone biosynthesis or the potassium channel KCNJ5 and related molecules. Read More

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http://dx.doi.org/10.1007/s42000-018-0072-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294814PMC
December 2018
1 Read

Comparison of Constructive Interference in Steady-State and T1-Weighted MRI Sequence at Detecting Pituitary Adenomas in Cushing's Disease Patients.

J Neurol Surg B Skull Base 2018 Dec 10;79(6):593-598. Epub 2018 May 10.

Department of Neurosurgery, Neurological Institute, Cleveland Clinic, Cleveland, Ohio, United States.

 T1-weighted magnetic resonance imaging (MRI) remains the standard pituitary imaging sequence. However, up to 50% of pituitary adenomas are missed with standard imaging in Cushing's disease (CD) patients. Utility of other imaging sequences needs be explored. Read More

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http://dx.doi.org/10.1055/s-0038-1642032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6239881PMC
December 2018
11 Reads

Calcifying nested stromal epithelial tumor of the liver in a patient with Klinefelter syndrome: a case report and review of the literature.

World J Surg Oncol 2018 Nov 19;16(1):227. Epub 2018 Nov 19.

Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine, 5, Zaifu, Hirosaki, Aomori, 036-8562, Japan.

Background: Calcifying nested stromal epithelial tumor (CNSET) is a primary neoplasm of the liver, characterized by well-demarcated nests consisting of spindle and epithelioid cells with calcification and bone formation. An association of Cushing syndrome with CNSET has drawn attention, but the origin of CNSET has not been clarified.

Case Presentation: We report here the case of a 20-year-old male with Klinefelter syndrome who underwent liver resection for an increasing liver tumor that was pathologically diagnosed with CNSET. Read More

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http://dx.doi.org/10.1186/s12957-018-1528-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6245822PMC
November 2018
1 Read

Carney Syndrome Presented as a Pathological Spine Fracture in a 35-Year-Old Male.

Am J Case Rep 2018 Nov 16;19:1366-1369. Epub 2018 Nov 16.

Fifth Surgical Clinic, Department of Surgery, National and Kapodistrian University of Athens School of Medicine, Athens, Greece.

BACKGROUND Carney complex (CNC) is a genetic disorder that presents as an adrenocorticotropic hormone (ACTH)-independent variant of endogenous Cushing syndrome. It was first reported in 1985 and was described as a form of multiple endocrine hyperplasia associated with mutations of the c-AMP-dependent protein kinase (PRKAR1A) gene that causes bilateral adrenal hyperplasia. We report a case of an incidentally found CNC in a 35-year-old male, and this case report focuses on the diagnostic scheme as well as the surgical treatment of this rare challenging condition. Read More

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https://www.amjcaserep.com/abstract/index/idArt/911962
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http://dx.doi.org/10.12659/AJCR.911962DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251001PMC
November 2018
5 Reads

Carney Complex.

Exp Clin Endocrinol Diabetes 2018 Nov 14. Epub 2018 Nov 14.

Section on Endocrinology and Genetics & Endocrinology Inter-institute Training Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA.

Carney complex is a rare, autosomal dominant, multiple endocrine neoplasia and lentiginosis syndrome, caused in most patients by defects in the gene, which encodes the regulatory subunit type 1α of protein kinase A. Inactivating defects of lead to aberrant cyclic-AMP-protein kinase A signaling. Patients may develop multiple skin abnormalities and a variety of endocrine and non-endocrine tumors. Read More

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http://www.thieme-connect.de/DOI/DOI?10.1055/a-0753-4943
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http://dx.doi.org/10.1055/a-0753-4943DOI Listing
November 2018
6 Reads

Corticotropin hormone assay interference: A case series.

Clin Biochem 2019 Jan 10;63:143-147. Epub 2018 Nov 10.

Division of Endocrinology, Diabetes, Metabolism, and Nutrition, Mayo Clinic, Rochester, MN, United States. Electronic address:

Measuring the plasma corticotropin (ACTH) concentration is an important step in determining the underlying cause in patients with hypercortisolemia. Interfering substances in immunoassays can lead to erroneous results impacting clinical management. We describe a case series of 12 patients, the majority of whom were being investigated for possible Cushing's syndrome and in whom inconsistencies between the clinical picture and biochemical testing raised concerns of assay interference. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2018.11.006DOI Listing
January 2019

Secondary Arterial Hypertension: From Routine Clinical Practice to Evidence in Patients with Adrenal Tumor.

High Blood Press Cardiovasc Prev 2018 Dec 10;25(4):345-354. Epub 2018 Nov 10.

Endocrinology Unit, Department of Medicine DIMED, University-Hospital of Padova, Via Ospedale Civile, 105, 35128, Padova, Italy.

Prevalence of arterial hypertension is up to 30-40% in epidemiological studies, it increases with aging and affects the cardiovascular risk. Essential form of hypertension is the most frequent; however, 5-10% of patients are affected by a specific and potentially reversible cause of increased blood pressure levels, called secondary hypertension. In general, all patients with young onset-age (< 40-50 years) or resistant hypertension should be screened for secondary forms. Read More

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http://link.springer.com/10.1007/s40292-018-0288-6
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http://dx.doi.org/10.1007/s40292-018-0288-6DOI Listing
December 2018
14 Reads

Thromboelastometry. Reproducibility of duplicate measurement performed by the RoTem® device.

Thromb Res 2018 12 31;172:139-141. Epub 2018 Oct 31.

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center and Fondazione Luigi Villa, Milan, Italy.

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http://dx.doi.org/10.1016/j.thromres.2018.10.030DOI Listing
December 2018

Accuracy of new recommendations for adrenal incidentalomas in the evaluation of excessive cortisol secretion and follow-up.

Eur J Clin Invest 2018 Nov 9:e13048. Epub 2018 Nov 9.

Department of Endocrinology and Nutrition, Joan XXIII University Hospital, Tarragona, Spain.

Objective: To evaluate whether the 2016 European Society of Endocrinology (ESE) recommendations for the management of adrenal incidentalomas accurately classifies those patients who do not require further follow-up.

Design And Methods: Single centre retrospective study. From 2010 to 2015, 130 patients with adrenal incidentaloma were evaluated and followed-up. Read More

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http://dx.doi.org/10.1111/eci.13048DOI Listing
November 2018

Support Needs of Patients with Cushing's Disease and Cushing's Syndrome: Results of a Survey Conducted in Germany and the USA.

Int J Endocrinol 2018 9;2018:9014768. Epub 2018 Oct 9.

Department of Neurosurgery, University of Duisburg-Essen, 45147 Essen, Germany.

Background: Cushing's disease (CD) and Cushing's syndrome (CS) are chronic illnesses, characterized by symptoms of prolonged hypercortisolism, which often changes to hypocortisolism after successful treatment. In view of the high disease burden of CD/CS patients and long-term impaired quality of life, the present survey was conducted to gain information about subjective illness distress and patients' specific needs in terms of supportive measures beyond medical interventions.

Patients And Methods: Cross-sectional questionnaire study including patients with CD treated in 2 German neurosurgical tertiary referral centers and CD/CS patient members of a US-based patient support group completed a survey inquiring about disease burden, coping strategies, and support needs. Read More

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http://dx.doi.org/10.1155/2018/9014768DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198616PMC
October 2018
10 Reads

Ectopic adrenocorticotropic hormone syndrome associated with olfactory neuroblastoma: acquirement of adrenocorticotropic hormone expression during disease course as shown by serial immunohistochemistry examinations.

J Int Med Res 2018 Nov;46(11):4760-4768

1 Department of Internal Medicine, Division of Diabetes, Endocrinology and Metabolism, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya, Hyogo, Japan.

Ectopic adrenocorticotropic hormone (ACTH) syndrome (EAS) is a condition of endogenous hypercortisolism sustained by an extrapituitary ACTH-secreting tumor. Olfactory neuroblastoma (ONB) is a rare malignant neoplasm of the sinonasal tract and is derived from the olfactory epithelium. Because the paranasal sinus is not a common site of EAS, the development of ONB in patients with EAS is rare. Read More

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http://journals.sagepub.com/doi/10.1177/0300060517754026
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http://dx.doi.org/10.1177/0300060517754026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6259372PMC
November 2018
6 Reads

Hypothalamic Vasopressin-Producing Tumors: Often Inappropriate Diuresis But Occasionally Cushing Disease.

Am J Surg Pathol 2019 Feb;43(2):251-260

Endocrine Oncology Site Group, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Tumors of hypothalamic neurons that produce vasopressin are rare. We retrieved all cases of vasopressin-positive tumors in the sellar region from the database of the Department of Pathology. Five cases fulfilled the selection criteria, representing the first series of such tumors. Read More

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http://dx.doi.org/10.1097/PAS.0000000000001185DOI Listing
February 2019
1 Read

TRH-induced secretion of adrenocorticotropin and cortisol in dogs with pituitary-dependent hypercortisolism.

Vet Q 2018 Dec;38(1):72-78

a Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine , Utrecht University , Utrecht , The Netherlands.

Background: In dogs, spontaneous Cushing's syndrome is most often pituitary-dependent and caused by hypersecretion of adrenocorticotropic hormone (ACTH), resulting in increased adrenocortical glucocorticoid secretion similar to horses. In horses with Cushing's syndrome (or pituitary pars intermedia dysfunction [PPID]) a thyrotropin-releasing hormone (TRH) stimulation test can be used for diagnosis, as TRH administration results in increased circulating ACTH and cortisol concentrations in affected horses.

Objective: The aim of this study was to investigate the effect of TRH administration on the circulating ACTH and cortisol concentrations in dogs with pituitary-dependent hypercortisolism (PDH). Read More

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https://www.tandfonline.com/doi/full/10.1080/01652176.2018.1
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http://dx.doi.org/10.1080/01652176.2018.1521537DOI Listing
December 2018
15 Reads

Treating canine Cushing's syndrome: Current options and future prospects.

Vet J 2018 Nov 27;241:42-51. Epub 2018 Sep 27.

Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 108, 3584 CM Utrecht, The Netherlands. Electronic address:

Naturally occurring hypercortisolism, also known as Cushing's syndrome, is a common endocrine disorder in dogs that can be caused by an adenocorticotrophic hormone (ACTH)-producing pituitary adenoma (pituitary-dependent hypercortisolism, PDH; 80-85% of cases), or by an adrenocortical tumor (ACT; 15-20% of cases). To determine the optimal treatment strategy, differentiating between these two main causes is essential. Good treatment options are surgical removal of the causal tumor, i. Read More

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http://dx.doi.org/10.1016/j.tvjl.2018.09.014DOI Listing
November 2018
1 Read

Diagnostic Testing for Elevated Cortisol in the Setting of an Adrenal Mass.

JAMA 2018 Oct;320(13):1373-1374

Division of Endocrinology, Department of Medicine, University of Florida, Gainesville.

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http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.20
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http://dx.doi.org/10.1001/jama.2018.13351DOI Listing
October 2018
7 Reads

Should we avoid using ketoconazole in patients with severe Cushing’s syndrome and increased levels of liver enzymes?

Eur J Endocrinol 2018 Oct 12;179(5):L1-L2. Epub 2018 Oct 12.

Department of Endocrinology, University Hospital of Bordeaux, Bordeaux, France

We read with interest the paper of Young et al. in which the authors recommend avoiding ketoconazole in the treatment of Cushing’s syndrome when patients display increased liver enzymes (>2-fold the upper limit of normal (ULN)). We found in a small series of patients that We read with interest the paper of Young et al. Read More

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http://dx.doi.org/10.1530/EJE-18-0694DOI Listing
October 2018

ACTH-Secreting Neuroendocrine Carcinoma of the Cecum: Case Report and Review of the Literature.

Clin Colorectal Cancer 2018 Aug 11. Epub 2018 Aug 11.

Division of Medical Oncology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. Electronic address:

Background: Approximately 30% of neuroendocrine tumors (NETs) present with secretory syndromes or develop one during the course of the disease. Cushing syndrome caused by a gastrointestinal tract NET is rare, with limited published information. We describe a patient with florid Cushing syndrome due to ectopic adrenocorticotropic hormone (ACTH) from a NET of colonic origin. Read More

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http://dx.doi.org/10.1016/j.clcc.2018.07.013DOI Listing
August 2018
1 Read

Is Prophylactic Steroid Treatment Mandatory for Subclinical Cushing Syndrome After Unilateral Laparoscopic Adrenalectomy?

Surg Laparosc Endosc Percutan Tech 2018 Oct 8. Epub 2018 Oct 8.

Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing.

Objective: This study aimed to provide rational guidelines for patients with subclinical Cushing syndrome (SCS), who are undergoing laparoscopic adrenalectomy, in order to avoid the risk of overtreatment.

Methods: A total of 59 patients diagnosed with SCS caused by unilateral adrenal adenoma, who underwent laparoscopic adrenalectomy from 2010 to 2017, were included into the study. These patients did not receive prophylactic steroid treatment. Read More

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http://Insights.ovid.com/crossref?an=00129689-900000000-9946
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http://dx.doi.org/10.1097/SLE.0000000000000585DOI Listing
October 2018
5 Reads

Dysregulation of Cortisol Metabolism in Equine Pituitary Pars Intermedia Dysfunction.

Endocrinology 2018 Nov;159(11):3791-3800

University/British Heart Foundation Centre for Cardiovascular Science, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.

Equine Cushing disease [pituitary pars intermedia dysfunction (PPID)] is a common condition of older horses, but its pathophysiology is complex and poorly understood. In contrast to pituitary-dependent hyperadrenocorticism in other species, PPID is characterized by elevated plasma ACTH but not elevated plasma cortisol. In this study, we address this paradox and the hypothesis that PPID is a syndrome of ACTH excess in which there is dysregulation of peripheral glucocorticoid metabolism and binding. Read More

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https://academic.oup.com/endo/advance-article/doi/10.1210/en
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http://dx.doi.org/10.1210/en.2018-00726DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202856PMC
November 2018
3 Reads

Surgery for Cushing's disease in pregnancy: our experience and a literature review.

Ann R Coll Surg Engl 2019 Jan 5;101(1):e26-e31. Epub 2018 Oct 5.

Department of Endocrinology, University Hospital Birmingham , Birmingham , UK.

Cushing's syndrome in pregnancy is a rare phenomenon and there is limited literature on its management. Cushing's disease in pregnancy is even less common and there is little guidance to help in the treatment for this patient group. Diagnosis of Cushing's syndrome in pregnancy is often delayed due to overlap of symptoms. Read More

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http://dx.doi.org/10.1308/rcsann.2018.0175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6303815PMC
January 2019
10 Reads

[Update on endocrine hypertension].

Internist (Berl) 2018 Nov;59(11):1163-1179

Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, Campus Innenstadt, Ziemssenstr. 1, 80336, München, Deutschland.

Endocrine disorders are the most common causes of secondary hypertension. Early diagnosis and specific treatment are crucial for improvement of the prognosis. This article provides an overview on which clinical constellations point to an increased risk of secondary causes of hypertension. Read More

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http://dx.doi.org/10.1007/s00108-018-0505-3DOI Listing
November 2018
2 Reads

Paraneoplastic Syndrome Secondary to Treatment Emergent Neuroendocrine Tumor in Metastatic Castration-resistant Prostate Cancer: A Unique Case.

Clin Genitourin Cancer 2018 Sep 7. Epub 2018 Sep 7.

Feinstein Institute for Medical Research, Manhasset, NY; Northwell Health Cancer Institute, Lake Success, NY. Electronic address:

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http://dx.doi.org/10.1016/j.clgc.2018.09.002DOI Listing
September 2018
3 Reads

Cushing Syndrome due to Inappropriate Corticosteroid Topical Treatment of Undiagnosed Scabies.

Trop Med Infect Dis 2018 Aug 3;3(3). Epub 2018 Aug 3.

Department of Dermatology and Mycology Acapulco General Hospital, Health Secretary Guerrero, Community Dermatology Mexico C.A., 39355 Acapulco, Guerrero, Mexico.

The uncontrolled sale of topical corticosteroids has become an important risk factor for the development of iatrogenic Cushing syndrome in children, especially in countries where medications are sold over the counter. This is exacerbated by the lack of information for both the patients and pharmacists. This report documents a series of eight cases of iatrogenic Cushing syndrome secondary to an inappropriate use of topical steroids, due to a misdiagnosis of scabies. Read More

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http://www.mdpi.com/2414-6366/3/3/82
Publisher Site
http://dx.doi.org/10.3390/tropicalmed3030082DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6161154PMC
August 2018
3 Reads

Transmastoid access in branchio-oto-renal syndrome: A reappraisal of computed tomography imaging.

Int J Pediatr Otorhinolaryngol 2018 Nov 27;114:92-96. Epub 2018 Aug 27.

Department of Otolaryngology-Head and Neck Surgery, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.

Objective: To evaluate for temporal bone abnormalities that might affect transmastoid surgery such as cochlear implantation in cases of branchio-oto-renal syndrome (BOR).

Study Design: Retrospective review.

Methods: Qualitative assessment of temporal bone computed tomography imaging was performed by a neuroradiologist for 30 individuals with BOR (60 ears) and 20 controls with normal hearing (20 ears). Read More

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https://linkinghub.elsevier.com/retrieve/pii/S01655876183043
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http://dx.doi.org/10.1016/j.ijporl.2018.08.030DOI Listing
November 2018
4 Reads

Hair cortisol analysis: An update on methodological considerations and clinical applications.

Clin Biochem 2019 Jan 24;63:1-9. Epub 2018 Sep 24.

Division of Clinical Pharmacology, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, Canada; Division of Endocrinology and Metabolism, Department of Medicine, Schulich School of Medicine and Dentistry, Western University, Canada. Electronic address:

Background: Hair cortisol analysis is increasingly being appreciated and applied in both research and medicine, aiding endocrinologists with diagnosis.

Content: We provide an overview of hair cortisol research in general and an update on methodological considerations including the incorporation of cortisol into hair, hair growth rates, and sampling procedures, mincing vs. grinding of samples during preparation for extraction, various extraction protocols, and quantification techniques. Read More

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http://dx.doi.org/10.1016/j.clinbiochem.2018.09.010DOI Listing
January 2019
2 Reads

Oncocytic neoplasms; rare adrenocortical tumours - a report of eleven patients.

Endokrynol Pol 2018 27;69(6):682-687. Epub 2018 Sep 27.

Department of Internal Medicine, Division of Endocrinology and Metabolism, Kastamonu State Hospital, Kastamonu, Turkey.

Introduction: Oncocytomas of adrenal glands are extremely rare and usually present as incidentally detected masses. We aimed to present a series of patients with adrenal oncocytomas and review the literature.

Material And Methods: Electronic database of patients with adrenal tumours, who were admitted to the internal medicine and endocrinology and metabolism outpatient clinics of Uludag University Medical Faculty between January 2005 and November 2016, were assessed retrospectively. Read More

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http://dx.doi.org/10.5603/EP.a2018.0066DOI Listing
September 2018
1 Read