13,656 results match your criteria Cushing Syndrome


Thiobarbituric acid reactive substances in dogs with spontaneous hypercortisolism.

Domest Anim Endocrinol 2021 May 15;77:106634. Epub 2021 May 15.

Department of Veterinary Clinical Pathology, School of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre-RS, Brazil.

Thiobarbituric acid reactive substances (TBARS) are laboratory markers of oxidative stress, which can be used to evaluate the lipid peroxidation that characterizes cell membrane damage caused by excess free radicals. This prospective study aimed to assess TBARS as a parameter of lipid peroxidation in dogs with spontaneous hypercortisolism (HC) at the time of diagnosis, and after trilostane treatment. Furthermore, it aimed to investigate the correlations between TBARS levels, and laboratory and cardiovascular parameters. Read More

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Atypical Carcinoid Tumor of the Mediastinum Presenting as Cushing's Syndrome in an Otherwise Healthy Young Male.

Cureus 2021 May 10;13(5):e14940. Epub 2021 May 10.

Medicine, Icahn School of Medicine, Queens Hospital Center, New York City, USA.

Primary neuroendocrine tumors (NETs) are rare types of malignancies that can have a variety of presentations due to the ubiquitous distribution of neuroendocrine cells within the body. While mediastinal masses are not uncommon, NETs arising from the anterior mediastinum are rare and often originate from the thymus gland. A subset of NETs, atypical carcinoids, are more commonly seen in the lungs or gastrointestinal organs and often present with endocrine syndromes, chiefly Cushing's syndrome. Read More

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Incidentally discovered myelolipomatous adrenal adenomas, including six cases presenting with hypercortisolism.

Pathol Res Pract 2021 Jun 6;224:153508. Epub 2021 Jun 6.

Department of Pathology, Indiana University, Indianapolis, IN, 46202, USA.

Most adrenal incidentalomas are non-functioning adenomas that require no treatment. The presence of a myelolipomatous component of adrenal incidentalomas is a rare, but well-known occurrence in both hyperplastic and neoplastic lesions of the adrenal cortex. Although the improvements in abdominal imaging have increased identification of myelolipomatous adrenal cortical adenomas radiologically, due to the rarity of this lesion, the clinical pathological features of these lesions are unclear and can sometimes cause diagnostic difficulty. Read More

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The role of bilateral inferior petrosal sinus sampling in determining the preoperative localization of ACTH-secreting pituitary microadenomas in Cushing's disease: Experience of a tertiary center.

Clin Neurol Neurosurg 2021 Jun 1;207:106724. Epub 2021 Jun 1.

Yildirim Beyazit University Faculty of Medicine, Department of Endocrinology and Metabolism, Ankara, Turkey. Electronic address:

Introduction: Bilateral inferior petrosal sinus sampling (BIPSS) is an important procedure in the diagnostic work-up of Cushing's syndrome (CS). In this study, we investigated the diagnostic performance of BIPSS in detecting the source of adrenocorticotropic hormone (ACTH) secretion in Cushing's disease (CD) without radiological evidence.

Methods: Thirty-five consecutive patients who underwent BIPSS due to ACTH-dependent CS between 2010 and 2019 in our clinic and subsequently underwent transsphenoidal surgery were included. Read More

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Tinea Incognito Mimicking Pustular Psoriasis in a Patient With Psoriasis and Cushing Syndrome.

Authors:
Gerhard Eichhoff

Cutis 2021 Apr;107(4):E30-E32

Dermatology Service Capital and Coast District Health Board, Wellington Regional Hospital, New Zealand.

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Nelson Syndrome: A Case Report and Literature Review.

AACE Clin Case Rep 2021 Mar-Apr;7(2):141-144. Epub 2020 Dec 28.

Endocrinology and Metabolism Department, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico.

Objective: Nelson syndrome (NS) is a rare clinical disorder that can occur after total bilateral adrenalectomy (TBA), performed as a treatment for Cushing disease. NS is defined as the accelerated growth of an adrenocorticotropic hormone-producing pituitary adenoma. Our objective is to describe a case of NS and discuss it based on existing knowledge of this syndrome. Read More

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December 2020

Intratumoral steroid profiling of adrenal cortisol-producing adenomas by liquid chromatography- mass spectrometry.

J Steroid Biochem Mol Biol 2021 Jun 2;212:105924. Epub 2021 Jun 2.

Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address:

Endogenous Cushing syndrome (CS) is an endocrine disorder marked by excess cortisol production rendering patients susceptible to visceral obesity, dyslipidemia, hypertension, osteoporosis and diabetes mellitus. Adrenal CS is characterized by autonomous production of cortisol from cortisol-producing adenomas (CPA) via adrenocorticotropic hormone-independent mechanisms. A limited number of studies have quantified the steroid profiles in sera from patients with CS. Read More

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Cushing syndrome and glucocorticoids: T-cell lymphopenia, apoptosis and rescue by IL-21.

J Allergy Clin Immunol 2021 Jun 2. Epub 2021 Jun 2.

Immunology Service, Department of Laboratory Medicine, NIH Clinical Center, NIH, Bethesda, MD, USA, 20892. Electronic address:

Background: Pediatric endogenous Cushing syndrome is mainly caused by pituitary corticotropin-producing adenomas and most glucocorticoid-dependent effects progressively regress upon tumor removal. Endogenous Cushing syndrome reproduces long-term high-dose glucocorticoid therapy, representing a clean, natural and unbiased model in which to study glucocorticoid bona-fide effects on immunity.

Objectives: To perform extensive immunologic studies in otherwise healthy pediatric patients with endogenous Cushing syndrome before and 6-13 months after tumor resection, as well as in in-vitro glucocorticoid-treated control cells. Read More

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Ectopic Cushing Syndrome in Adenocarcinoma of the Lung: Case Report and Literature Review.

Cureus 2021 Apr 28;13(4):e14733. Epub 2021 Apr 28.

Internal Medicine, Richmond University Medical Center, Staten Island, USA.

Paraneoplastic syndromes are rare disorders that occur with many types of tumors. Ectopic cushing syndrome (ECS) is the second most common paraneoplastic syndrome that is only seen in 1-5% of all small cell lung cancers (SCLC), with limited papers reporting this syndrome since it was first described by Brown in 1928 or in carcinoid tumors. It is also found to be associated to a lesser extent with pheochromocytoma, thymic tumors, pancreatic carcinoma, and anaplastic thyroid carcinoma. Read More

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A most versatile kinase: The catalytic subunit of PKA in T-cell biology.

Authors:
Thomas S Postler

Int Rev Cell Mol Biol 2021 27;361:301-318. Epub 2021 Jan 27.

Department of Microbiology & Immunology, Vagelos College of Physicians & Surgeons, Columbia University Irving Medical Center, New York, NY, United States. Electronic address:

The cAMP-dependent protein kinase, more commonly referred to as protein kinase A (PKA), is one of the most-studied enzymes in biology. PKA is ubiquitously expressed in mammalian cells, can be activated in response to a plethora of biological stimuli, and phosphorylates more than 250 known substrates. Indeed, PKA is of central importance to a wide range of organismal processes, including energy homeostasis, memory formation and immunity. Read More

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January 2021

The importance of adrenal venous sampling in ACTH-independent Cushing syndrome: A case report and literature review.

Exp Ther Med 2021 Jul 18;22(1):772. Epub 2021 May 18.

Discipline of Pediatric Surgery, Faculty of Medicine, 'Carol Davila' University of Medicine and Pharmacy, 020021 Bucharest, Romania.

Independent Cushing's adrenocorticotropic hormone (ACTH) syndrome can have several causes, including adrenal carcinoma or simple adrenal hyperplasia. Although the distinction between malignant and benign can be effectively made through imaging investigations, in the situation where there are bilateral formations, their hormonal activity is impossible to appreciate via non-invasive techniques. The present study includes the presentation of a clinical case on the basis of which a literature review was made. Read More

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Acute elevation of interleukin 6 and matrix metalloproteinase 9 during the onset of pituitary apoplexy in Cushing's disease.

Pituitary 2021 May 26. Epub 2021 May 26.

Department of Genetics, Cell Biology and Development, University of Minnesota, 321 Church St. SE., 6-160 Jackson Hall, Minneapolis, MN, 55455, USA.

Purpose: Pituitary apoplexy is a rare endocrine emergency. The purpose of this study is to characterize physiological changes involved in pituitary apoplexy, especially during the acute phase.

Methods: A Cushing's disease patient experienced corticotroph releasing hormone (CRH)-induced pituitary apoplexy during inferior petrosal sinus sampling (IPSS). Read More

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Avascular femoral necrosis as part of Cushing syndrome presentation: a case report.

J Med Case Rep 2021 May 26;15(1):287. Epub 2021 May 26.

Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universitário de São João, 4200-319, Porto, Portugal.

Background: The clinical characteristics and complications of Cushing syndrome (CS) are well known and described in the literature. Nevertheless, rare, atypical presentations may go unnoticed. Osteonecrosis is a well-documented complication of glucocorticoid therapy. Read More

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Ectopic Cushing syndrome in Colombia.

Arch Endocrinol Metab 2021 May;64(6):687-694

Departamento de Neoplasia Endocrina y Trastornos Hormonales, Universidad de Texas, MD Anderson Cancer Center, Houston Texas.

Objective: The aim was to describe the clinical features of patients with ectopic Cushing syndrome (ECS) from Colombia and compare these findings with other series to provide the best management for these patients.

Methods: Records of patients with ECS from 1986 to 2017 were retrospectively reviewed; patients with a diagnosis of adrenal or pituitary Cushing syndrome (CS) were excluded.

Results: Fourteen patients with ECS were analyzed in this study. Read More

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The Pioneer Neuropharmacologist Alfred Fröhlich (1871-1953) and the Origins of Neuroendocrinology: A Sesquicentennial Remembrance.

Neuroscientist 2021 May 24:10738584211016777. Epub 2021 May 24.

Laboratory of Theoretical and Applied Neuroscience, University of Macedonia School of Social Sciences, Humanities and Arts, Thessalonica, Greece.

The birth of neuroendocrinology as a scientific discipline is traced back to 1900-1901, when Joseph Babinski, Alfred Fröhlich, and Harvey Cushing independently identified adiposogenital dystrophy (Fröhlich syndrome), and related gonadal underdevelopment and obesity to a tumor near the pituitary gland. This discovery prompted decades of research into the brain mechanisms responsible for the control of peripheral metabolism and endocrine functions. On the occasion of the 150th anniversary of Fröhlich's birth, this study traces the origins of his intellectual formation and his association with renowned contemporaries in Austria, England, Italy, and finally Cincinnati, Ohio, where he sought refuge after Austria's annexation by Nazi Germany. Read More

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The New York State SARS-CoV-2 Testing Consortium: Regional Communication in Response to the COVID-19 Pandemic.

Acad Pathol 2021 Jan-Dec;8:23742895211006818. Epub 2021 May 7.

Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA.

The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2, created an unprecedented need for comprehensive laboratory testing of populations, in order to meet the needs of medical practice and to guide the management and functioning of our society. With the greater New York metropolitan area as an epicenter of this pandemic beginning in March 2020, a consortium of laboratory leaders from the assembled New York academic medical institutions was formed to help identify and solve the challenges of deploying testing. This report brings forward the experience of this consortium, based on the real-world challenges which we encountered in testing patients and in supporting the recovery effort to reestablish the health care workplace. Read More

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Development of Cushing Syndrome After Serial In-office Subglottic Steroid Injections.

Laryngoscope 2021 May 18. Epub 2021 May 18.

Caruso Department of Otolaryngology-Head and Neck Surgery, Keck School of Medicine, University of Southern California, Los Angeles, California, U.S.A.

In-office subglottic intralesional steroid injections (SILSI) have gained popularity as an adjunct to operating room dilation in the treatment of subglottic stenosis. They are generally thought to have a low risk profile for development of systemic side effects. Here, we present a case of a 55 year old woman who developed symptoms of Cushing syndrome after receiving SILSI, including weight gain, striae, dorsal hump and alopecia. Read More

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Image of the month: Diagnostic and therapeutic challenges in the management of ectopic ACTH syndrome: a perfect storm of hypercortisolism, hyperglycaemia and COVID-19.

Authors:
Tejhmal Rehman

Clin Med (Lond) 2021 05;21(3):231-234

Shifa International Hospital, Islamabad, Pakistan

Cushing's syndrome is a rare endocrine disorder requiring a high degree of clinical suspicion and meticulous investigations to diagnose and manage optimally. Delayed diagnosis and suboptimal treatment are associated with increased morbidity and mortality. Uncontrolled hypercortisolism leads to multiple cardiovascular and metabolic complications. Read More

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Method-Specific Cortisol and Dexamethasone Thresholds Increase Clinical Specificity of the Dexamethasone Suppression Test for Cushing Syndrome.

Clin Chem 2021 May 17. Epub 2021 May 17.

Department of Internal Medicine I, Division of Endocrinology and Diabetes, University Hospital Würzburg, Würzburg, Germany.

Background: The dexamethasone suppression test (DST) is the recommended first-tier test for suspected Cushing syndrome (CS). Missed dexamethasone intake or insufficient dexamethasone serum exposure may yield false positive results. Quantification of serum dexamethasone in DST samples may therefore improve test performance. Read More

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Consideration triggered by the choice of heterophilic antibody interference detection tests in measuring ACTH for a teenager boy with a rare adrenal disease.

Clin Chim Acta 2021 Aug 12;519:210-213. Epub 2021 May 12.

Department of Clinical Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Science, Beijing 100730, PR China. Electronic address:

Background: Plasma ACTH is an important marker for Cushing syndrome; inaccurate measurement of ACTH concentrations due to the serum heterophile antibody may mislead diagnosis by physicians. We describe the case of a teenage boy with a rare adrenal disease who presented falsely increased ACTH concentrations (20.3 pg/ml; Siemens Immulite). Read More

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Postmenopausal hyperandrogenism.

Authors:
T Yoldemir

Climacteric 2021 May 14:1-9. Epub 2021 May 14.

Department of Obstetrics and Gynaecology, Marmara University Hospital, Istanbul, Turkey.

Postmenopausal hyperandrogenism is a state of relative or absolute androgen excess originating from the adrenal glands and/or ovaries clinically manifested by the presence of terminal hair in androgen-dependent areas of the body, and other manifestations of hyperandrogenism such as acne and alopecia or the development of virilization. In such circumstances, physicians must exclude the possibility of rare but serious androgen-producing tumors of the adrenal glands or ovaries. Worsening of undiagnosed hyperandrogenic disorders such as polycystic ovary syndrome, congenital adrenal hyperplasia, ovarian hyperthecosis, Cushing syndrome and iatrogenic hyperandrogenism should be considered for differential diagnosis. Read More

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Hypoglycemia in a Patient with Hypercortisolism and Adrenocortical Carcinoma: A Paradoxical Entity.

J Adolesc Young Adult Oncol 2021 May 12. Epub 2021 May 12.

Department of Internal Medicine, Guthrie Robert Packer Hospital, Sayre, Pennsylvania, USA.

Adrenal cortical carcinoma is a rare and aggressive cancer with poor prognosis. Cases usually present with signs and symptoms of excessive hormone production. Hyperglycemia and Cushing syndrome are common, but tumor-associated hypoglycemia due to paraneoplastic secretion of insulin-like growth factor-2 (termed Anderson's syndrome) is uncommon. Read More

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Risk of miscarriage in women with chronic diseases in Norway: A registry linkage study.

PLoS Med 2021 May 10;18(5):e1003603. Epub 2021 May 10.

Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway.

Background: Increased risk of miscarriage has been reported for women with specific chronic health conditions. A broader investigation of chronic diseases and miscarriage risk may uncover patterns across categories of illness. The objective of this study was to study the risk of miscarriage according to various preexisting chronic diseases. Read More

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Divergent and self-reactive immune responses in the CNS of COVID-19 patients with neurological symptoms.

Cell Rep Med 2021 May 3;2(5):100288. Epub 2021 May 3.

Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA.

Individuals with coronavirus disease 2019 (COVID-19) frequently develop neurological symptoms, but the biological underpinnings of these phenomena are unknown. Through single-cell RNA sequencing (scRNA-seq) and cytokine analyses of cerebrospinal fluid (CSF) and blood from individuals with COVID-19 with neurological symptoms, we find compartmentalized, CNS-specific T cell activation and B cell responses. All affected individuals had CSF anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies whose target epitopes diverged from serum antibodies. Read More

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Pediatric Cushing syndrome: An early sign of an underling cancer predisposition syndrome.

Am J Med Genet A 2021 May 7. Epub 2021 May 7.

Department of Pediatrics, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Beckwith-Wiedemann syndrome (BWS) is a genetic overgrowth and cancer predisposition syndrome that can be associated with a spectrum of clinical features including isolated lateralized overgrowth, macrosomia, macroglossia, organomegaly, omphalocele/umbilical hernia, and distinct facial features. Because of a range of clinical presentations and molecular defects involving Chromosome 11p15, many cases will fall within what is now being defined as the Beckwith-Wiedemann spectrum (BWSp). Cushing syndrome (CS) in infants is a rare neuroendocrinological disease associated with hypercortisolism that has rarely been reported in patients with BWS. Read More

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Iatrogenic Cushing's Syndrome in Patients with Superficial Dermatophytosis.

Indian Dermatol Online J 2021 Mar-Apr;12(2):237-243. Epub 2021 Mar 2.

Department of Endocrinology and Metabolism University College of Medical Sciences and GTB Hospital (University of Delhi), Delhi, India.

Background: The epidemic-like scenario of superficial fungal infections in India has been complicated by the prescription of systemic and topical potent steroids. As a result, alarming number of patients are presenting with exogenous Cushing's syndrome.

Methods: This cross-sectional study involved 23 patients of superficial dermatophytosis on steroids who presented with clinical features like that of Cushing's syndrome. Read More

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Functional Adrenocortical Carcinoma: A Rare Case With Thrombus Extension Into the Inferior Vena Cava and a Presentation of Cushing Syndrome.

Cureus 2021 Apr 1;13(4):e14239. Epub 2021 Apr 1.

Faculty of Medicine, Memorial University of Newfoundland, St. John's, CAN.

Adrenocortical carcinoma (ACC) is a rare, highly malignant endocrine tumor, often associated with a poor prognosis. Most patients who develop ACC are either children of ages 1-6, or adults in their fourth to fifth decade of life. Individuals with a functional cortisol-secreting ACC frequently present with Cushing syndrome. Read More

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Ectopic ACTH secretion from a metastatic gastric carcinoma with neuroendocrine component.

BMJ Case Rep 2021 May 6;14(5). Epub 2021 May 6.

Department of Diabetes and Endocrinology, Mater Dei Hospital, Msida, Malta.

An elderly gentleman was admitted to hospital with severe hypokalaemia of 1.75mmol/L. A background of a recently diagnosed metastatic gastric carcinoma with a neuroendocrine component pointed towards the diagnosis of ectopic ACTH secretion causing this dangerous electrolyte imbalance. Read More

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Adrenal and Hepatic Venous Sampling in a Case of Aldosterone-Producing Adrenocortical Carcinoma with Hepatic Metastasis.

Case Rep Endocrinol 2021 14;2021:5584198. Epub 2021 Apr 14.

Division of Endocrinology and Metabolism, Japanese Red Cross Musashino Hospital, Tokyo, Japan.

Background: Adrenocortical carcinoma (ACC) is a rare and highly aggressive malignancy. ACCs often secrete adrenal steroid hormones including cortisol and androgens; however, aldosterone-producing ACC is very rare. Although adrenal production of aldosterone is assessed by adrenal venous sampling, the use of sampling from the relevant vein to assess aldosterone production from a tumor arising from ACC metastasis has not been previously reported. Read More

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Diagnostic Role of PET/CT Tracers in the Detection and Localization of Tumours Responsible for Ectopic Cushing's Syndrome.

Anticancer Res 2021 May;41(5):2477-2484

Department of Biomedical Imaging and Image-guided Therapy, Division of Nuclear Medicine, Medical University of Vienna, Vienna, Austria.

Background/aim: Positron emission tomography/computed tomography (PET/CT) plays an important role in cancer localization in ectopic Cushing's syndrome (ECS). However, the choice of the optimal tracer for investigation of this disease is still unclear. We aimed to evaluate the diagnostic feasibility of [F]fluoro-2-deoxyglucose ([F]FDG), [F]fluoro-L-dihydroxyphenylalanine ([F] FDOPA), and [Ga]-DOTA-1-Nal3-octreotide ([Ga]-DOTANOC) in ECS. Read More

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