13,342 results match your criteria Cushing Syndrome


Invasive Thymoma with Right Upper Lobe Endobronchial Lesion and Autoimmune Enteropathy.

Case Rep Pulmonol 2020 20;2020:6396915. Epub 2020 Jun 20.

Department of Pulmonary Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Thymomas are slow-growing neoplasia arising from the epithelial cells of the thymus that usually present with respiratory symptoms, superior vena cava syndrome, or parathymic syndromes. Approximately 30% of thymomas develop myasthenia gravis. An additional 5% of patients with thymomas have other systemic syndromes, including rheumatoid arthritis, thyroiditis, red cell aplasia, systemic lupus erythematosus, and Cushing syndrome. Read More

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http://dx.doi.org/10.1155/2020/6396915DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322609PMC

Pediatric adrenocortical tumours.

Best Pract Res Clin Endocrinol Metab 2020 Jul 3:101448. Epub 2020 Jul 3.

St. Jude Children's Research Hospital, Memphis, TN, USA.

Childhood adrenocortical tumors (ACTs) are rare, representing ∼0.2% of all pediatric malignancies and having an incidence of 0.2-0. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101448DOI Listing

Spinal epidural lipomatosis with osteoporotic vertebral fracture presenting as acute thoracic myelopathy in a 33-year-old man with Cushing's disease.

World Neurosurg 2020 Jul 4. Epub 2020 Jul 4.

Department of Otolaryngology, Sir HN Reliance Foundation Hospital and Research Center, Mumbai, Maharashtra, India.

Background: Steroid-related spinal epidural lipomatosis (SEL) is a well-known condition most commonly encountered in patients taking chronic steroid medications. Endogenous Cushing's syndrome is a rare cause of SEL. The authors report an unusual presentation of acute thoracic myelopathy due to SEL with osteoporotic vertebral compression fractures in a patient with Cushing's disease. Read More

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http://dx.doi.org/10.1016/j.wneu.2020.06.212DOI Listing

Liver metastases from pituitary carcinomas mimicking visceral well-differentiated neuroendocrine tumors: a series of four cases.

Diagn Pathol 2020 Jul 4;15(1):81. Epub 2020 Jul 4.

Division of Anatomic Pathology, Mayo Clinic, 200 First St SW, Rochester, MN, 55905, USA.

Background: Pathologists frequently encounter neuroendocrine tumors (NETs) presenting as multiple liver masses in routine practice. Most often, these are well-differentiated tumors with characteristic histologic features. In contrast, pituitary carcinoma is very rare, and there is limited data on its natural history and pathologic characterization. Read More

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http://dx.doi.org/10.1186/s13000-020-00997-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7335443PMC

Paediatric population pharmacokinetic modelling to assess hydrocortisone replacement dosing regimens in young children.

Eur J Endocrinol 2020 Jul 1. Epub 2020 Jul 1.

C Kloft, Department of Clinical Pharmacy and Biochemistry, Freie Universität Berlin Institute of Pharmacy, Berlin, 12169, Germany.

Context: Accurate hydrocortisone dosing in children with adrenal insufficiency is important to avoid the risks of over and under treatment including iatrogenic Cushing`s syndrome and adrenal crisis.

Objective: To establish a population pharmacokinetic model of hydrocortisone in children and use this to refine hydrocortisone replacement regimens.

Design And Methods: Pharmacokinetic study of hydrocortisone granules, available in 0. Read More

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http://dx.doi.org/10.1530/EJE-20-0231DOI Listing

Glucocorticoid excess in patients with pheochromocytoma compared to paraganglioma and other forms of hypertension.

J Clin Endocrinol Metab 2020 Jul 1. Epub 2020 Jul 1.

Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Germany.

Context: Catecholamines and adrenocortical steroids are important regulators of blood pressure. Bidirectional relationships between adrenal steroids and catecholamines have been established but whether this is relevant to patients with pheochromocytoma is unclear.

Objective: This study addresses the hypothesis that patients with pheochromocytoma and paraganglioma (PPGL) have altered steroid production compared to primary hypertensives. Read More

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http://dx.doi.org/10.1210/clinem/dgaa423DOI Listing

Ectopic Cushing syndrome in Colombia.

Arch Endocrinol Metab 2020 Jun 29. Epub 2020 Jun 29.

Departamento de Neoplasia Endocrina y Trastornos Hormonales, Universidad de Texas, MD Anderson Cancer Center, Houston Texas.

Objective: The aim was to describe the clinical features of patients with ectopic Cushing syndrome (ECS) from Colombia and compare these findings with other series to provide the best management for these patients.

Materials And Methods: Records of patients with ECS from 1986 to 2017 were retrospectively reviewed; patients with a diagnosis of adrenal or pituitary Cushing syndrome (CS) were excluded.

Results: Fourteen patients with ECS were analyzed in this study. Read More

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http://dx.doi.org/10.20945/2359-3997000000271DOI Listing

Circulating Plasma microRNA to Differentiate Cushing's Disease From Ectopic ACTH Syndrome.

Front Endocrinol (Lausanne) 2020 5;11:331. Epub 2020 Jun 5.

The National Medical Research Centre for Endocrinology, Moscow, Russia.

Corticotropinomas and adrenocorticotropic hormone (ACTH)-secreting neuroendocrine tumors exhibit differential levels of some microRNAs (miRs) compared to normal tissue. Because miRs can be released from tissues into circulation, they offer promise as novel disease biomarkers. To evaluate whether miRs are differentially detected in plasma samples of patients with ACTH-dependent Cushing's syndrome (CS). Read More

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http://dx.doi.org/10.3389/fendo.2020.00331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7291947PMC

Cushing syndrome cardiomyopathy: an unusual manifestation of small-cell lung cancer.

ESC Heart Fail 2020 Jun 23. Epub 2020 Jun 23.

Department of Medicine, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, CT, 06030-2202, USA.

Cushing syndrome is a rare cause of dilated cardiomyopathy and heart failure with reduced ejection fraction. Cases describing this association are scarce. We describe a patient presenting with acute heart failure, new cardiomyopathy, refractory hypokalaemia, severe hyperglycaemia, and uncontrolled hypertension who was found to have hypercortisolism secondary to an ectopic adrenocorticotropic hormone-secreting primary lung neoplasm. Read More

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http://dx.doi.org/10.1002/ehf2.12860DOI Listing

CHEK2 Mutation in Patient with Multiple Endocrine Glands Tumors. Case Report.

Int J Environ Res Public Health 2020 Jun 18;17(12). Epub 2020 Jun 18.

Department of Gynecological Endocrinology, Poznan University of Medical Sciences, 61-701 Poznan, Poland.

Background: Many studies show the occurrence of several multiple endocrine neoplasia syndromes caused by different mutations, for example, in MEN1 and RET genes. Nevertheless, there are less common mutations causing multiple endocrine glands tumors. Examples of such mutations are CHEK2 gene mutations, causing breast, kidney, gastric, colorectal, prostate, lung, ovarian, and thyroid cancers. Read More

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http://dx.doi.org/10.3390/ijerph17124397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7344706PMC

Ectopic Cushing syndrome caused by a pancreatic neuroendocrine tumor: A case report.

Radiol Case Rep 2020 Jul 26;15(7):1014-1017. Epub 2020 May 26.

The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, JHOC 3140E, 601 North Caroline St, Baltimore, MD, USA.

Cushing syndrome is a disorder that occurs when the body is exposed to a higher than normal level of the hormone cortisol. It is most commonly caused by exogenous glucocorticoids, and less commonly due to endogenous sources. Ectopic adrenocorticotropic hormone (ACTH) syndrome is one of the rare causes of endogenous Cushing syndrome engendered by oversecretion of ACTH from a tumor outside of the pituitary or adrenal glands. Read More

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http://dx.doi.org/10.1016/j.radcr.2020.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283937PMC

Transcriptome analysis reveals the mechanism of fluorine exposure on memory loss of common carp.

Environ Pollut 2020 Jun 9;265(Pt A):114927. Epub 2020 Jun 9.

College of Animal Science and Technology, Jilin Agricultural University, Changchun, 130118, China; Ministry of Education Laboratory of Animal Production and Quality Security, Jilin Agricultural University, Changchun, 130118, China. Electronic address:

Fluorine, an environmental toxicant in our daily life, has been reported to have adverse effects on nervous system. Previous studies demonstrated that fluorine exposure could induce brain injury in fish and human. However, the possible mechanism remains unclear. Read More

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http://dx.doi.org/10.1016/j.envpol.2020.114927DOI Listing

Laboratory assessment of trilostane treatment in dogs with pituitary-dependent hyperadrenocorticism.

J Vet Intern Med 2020 Jun 13. Epub 2020 Jun 13.

Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, California, USA.

Background: Results of ACTH stimulation test (ACTHst), pre- and post-trilostane serum cortisol concentrations (SCCs), urine concentration (urine-specific gravity [USG]), and urine cortisol : creatinine ratios (UCCRs) are common variables used to monitor trilostane treatment of dogs with pituitary-dependent hyperadrenocorticism (PDH). However, none has consistently discriminated dogs receiving an adequate dose (A) from those overdosed (O) or underdosed (U).

Objectives: To assess and compare recommended monitoring variables, including serial SCCs in a cohort of dogs with PDH treated with trilostane. Read More

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http://dx.doi.org/10.1111/jvim.15830DOI Listing

Clinical Performance of SARS-CoV-2 Molecular Testing.

J Clin Microbiol 2020 Jun 8. Epub 2020 Jun 8.

Department of Pathology & Cell Biology, Columbia University Irving Medical Center, New York, NY

Molecular testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the gold standard for diagnosis of coronavirus disease 2019 (COVID-19), but the clinical performance of these tests is still poorly understood, particularly with regard to disease course, patient-specific factors, and viral shedding. From 3/10/2020-5/1/2020 NewYork-Presbyterian laboratories performed 27,377 SARS-CoV-2 molecular assays from 22,338 patients. Repeat testing was performed for 3,432 patients, of which 2,413 had initial negative and 802 had initial positive results. Read More

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http://dx.doi.org/10.1128/JCM.00995-20DOI Listing

Dietary sodium intake and cortisol measurements.

Clin Endocrinol (Oxf) 2020 Jun 8. Epub 2020 Jun 8.

Division of Endocrinology, Diabetes and Hypertension, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Objectives: To assess the influence of a dietary sodium intake intervention on cortisol measurements within the general population.

Design: Cross-over intervention.

Patients: Six hundred thirty adults without known Cushing syndrome, cardiovascular or renal disease completed a restricted dietary sodium diet (10 mmol/d, 230 mg/d) followed by cross-over to a liberalized dietary sodium diet (200 mmol/d, 4600 mg/d). Read More

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http://dx.doi.org/10.1111/cen.14262DOI Listing

Shotgun Transcriptome and Isothermal Profiling of SARS-CoV-2 Infection Reveals Unique Host Responses, Viral Diversification, and Drug Interactions.

bioRxiv 2020 May 1. Epub 2020 May 1.

Department of Physiology and Biophysics, Weill Cornell Medicine, NY, USA.

The Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused thousands of deaths worldwide, including >18,000 in New York City (NYC) alone. The sudden emergence of this pandemic has highlighted a pressing clinical need for rapid, scalable diagnostics that can detect infection, interrogate strain evolution, and identify novel patient biomarkers. To address these challenges, we designed a fast (30-minute) colorimetric test (LAMP) for SARS-CoV-2 infection from naso/oropharyngeal swabs, plus a large-scale shotgun metatranscriptomics platform (total-RNA-seq) for host, bacterial, and viral profiling. Read More

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http://dx.doi.org/10.1101/2020.04.20.048066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255793PMC

Adrenocortical tumorigenesis: Lessons from genetics.

Best Pract Res Clin Endocrinol Metab 2020 May 23:101428. Epub 2020 May 23.

Section on Endocrinology and Genetics & Inter-Institute Endocrinology Fellowship Program, Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, 20892, USA. Electronic address:

Advances in genomics over the past two decades have allowed for elucidation of the genetic alterations leading to the development of adrenocortical tumors and/or hyperplasias. These molecular changes were initially discovered through the study of rare familial tumor syndromes such as McCune-Albright Syndrome, Carney complex, Li-Fraumeni syndrome, and Beckwith-Wiedemann syndrome, with the identification of alterations in genes and molecular pathways that subsequently led to the discovery of aberrations in these or related genes and pathways in sporadic tumors. Genetic alterations in GNAS, PRKAR1A, PRKACA, PRKACB, PDE11A, and PDE8B, that lead to aberrant cyclic adenosine monophosphate-protein (cAMP) kinase A signaling, were found to play a major role in the development of benign cortisol-producing adrenocortical tumors and/or hyperplasias, whereas genetic defects in KCNJ5, ATP1A1, ATP2B3, CACNA1D, CACNA1H, and CLCN2 were implicated in the development of benign aldosterone-producing tumors and/or hyperplasias through modification of intracellular calcium signaling. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101428DOI Listing

SARS-CoV-2 antibody characterization in emergency department, hospitalized and convalescent patients by two semi-quantitative immunoassays.

Clin Chim Acta 2020 Jun 4;509:117-125. Epub 2020 Jun 4.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, USA; New York-Presbyterian Hospital, Weill Cornell Medicine, New York, NY, USA. Electronic address:

Background: In the ongoing COVID-19 pandemic, there is an urgent need for comprehensive performance evaluation and clinical utility assessment of serological assays to understand the immune response to SARS-CoV-2.

Methods: IgM/IgG and total antibodies against SARS-CoV-2 were measured by a cyclic enhanced fluorescence assay (CEFA) and a microsphere immunoassay (MIA), respectively. Independent performance evaluation included imprecision, reproducibility, specificity and cross-reactivity (CEFA n = 320, MIA n = 364). Read More

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http://dx.doi.org/10.1016/j.cca.2020.06.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272145PMC

Neonatal Cushing Syndrome.

Indian J Pediatr 2020 Jun 4. Epub 2020 Jun 4.

Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

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http://dx.doi.org/10.1007/s12098-020-03363-3DOI Listing
June 2020
0.919 Impact Factor

Inhibin A as a tumor marker for primary bilateral macronodular adrenal hyperplasia.

Endocrinol Diabetes Metab Case Rep 2020 Apr 29;2020. Epub 2020 Apr 29.

Section on Endocrinology and Genetics, Eunice Kennedy Shriver National Institute of Child Health and Human Development.

Summary: Primary bilateral macronodular adrenal hyperplasia (PBMAH) is a rare cause of ACTH-independent Cushing syndrome (CS). This condition is characterized by glucocorticoid and/or mineralocorticoid excess, and is commonly regulated by aberrant G-protein coupled receptor expression may be subclinical, allowing the disease to progress for years undetected. Inhibin A is a glycoprotein hormone and tumor marker produced by certain endocrine glands including the adrenal cortex, which has not been previously investigated as a potential tumor marker for PBMAH. Read More

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http://dx.doi.org/10.1530/EDM-20-0006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7219132PMC

Pregnancy during the course of Cushing's syndrome: a case report and literature review.

Endocrinol Diabetes Metab Case Rep 2020 Apr 12;2020. Epub 2020 Apr 12.

Division of Endocrinology, Guillermo Almenara Irigoyen National Hospital, Lima, Peru.

Summary: Cushing's syndrome is an endocrine disorder that causes anovulatory infertility secondary to hypercortisolism; therefore, pregnancy rarely occurs during its course. We present the case of a 24-year-old, 16-week pregnant female with a 10-month history of unintentional weight gain, dorsal gibbus, nonpruritic comedones, hirsutism and hair loss. Initial biochemical, hormonal and ultrasound investigations revealed hypokalemia, increased nocturnal cortisolemia and a right adrenal mass. Read More

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http://dx.doi.org/10.1530/EDM-20-0022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7159255PMC

[Exogenous Cushing syndrome due to drug interaction of ritonavir and inhaled fluticasone. Report of three pediatric cases].

Arch Argent Pediatr 2020 06;118(3):e278-e283

Servicio de Infectología, Centro de Referencia de Sida Pediátrico, Hospital de Niños "Dr. Ricardo Gutiérrez", Buenos Aires, Argentina.

The increase in life expectancy with the advent of highly effective antiretroviral therapy poses challenges in terms of toxicity and drug interactions. Exogenous Cushing syndrome by interaction between ritonavir and inhaled fluticasone in children diagnosed with human immunodeficiency virus infection and chronic pulmonary pathology is rare. So far, there are 20 cases reported. Read More

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http://dx.doi.org/10.5546/aap.2020.e278DOI Listing

Iatrogenic Cushing Syndrome And Hypertension In An Infant Girl Due To Use Of Nappy Rash Cream Containing A Potent Topical Steroid.

J Ayub Med Coll Abbottabad 2020 Jan- Mar;32(1):152

Department of Paediatrics, Ayub Medical College, Abbottabad, Pakistan.

Eleven months old female patient presented to paediatric out patient with parents concerned about her facial swelling. Upon examination child's weight and height for age were normal on her percentiles, she had a cushingoid facies with plethoric cheeks (Figure-1,2) though generalized oedema was absent and there was centripetal obesity with some muscle wasting (Figure-3,4). Systemic examination was normal excluding blood pressure which was high for her age. Read More

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Iatrogenic Cushing syndrome and multifocal osteonecrosis caused by the interaction between inhaled fluticasone and ritonavir.

BMJ Case Rep 2020 May 27;13(5). Epub 2020 May 27.

Serviço de Endocrinologia, Universidade de Lisboa Faculdade de Medicina, Lisboa, Portugal

Inhaled corticosteroids are generally considered safe and do not usually lead to systemic adverse events since their plasma concentrations are low due to hepatic metabolism by the cytochrome P450 3A4. However, when associated with inhibitors of this cytochrome, such as ritonavir, they may lead to iatrogenic Cushing syndrome by the systemic accumulation of corticosteroids and consequent suppression of the hypothalamic-pituitary-adrenal axis. We present a case of iatrogenic Cushing syndrome complicated by multifocal osteonecrosis in a patient with HIV infection on antiretroviral therapy with protease inhibitors boosted with ritonavir, after the association of inhaled fluticasone. Read More

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http://dx.doi.org/10.1136/bcr-2019-233712DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7259854PMC

[Bilateral pneumonia in a patient with Cushing's syndrome].

Rev Esp Quimioter 2020 May 28. Epub 2020 May 28.

Juan Monte Armenteros, Servicio de Medicina Interna, Hospital Universitario Cruces, Barakaldo, Spain.

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http://dx.doi.org/10.37201/req/001.2020DOI Listing

Diagnostic challenges and considerations of cyclical Cushing's syndrome in a 15-year-old female.

Pediatr Endocrinol Diabetes Metab 2020 ;26(2):104-107

Pediatrics, University of Missouri School of Medicine, United States.

Cyclical Cushing's syndrome (CS) is a rare disorder in which cortisol secretion is cyclical and intermittent. This phenomenon makes for a challenging diagnosis, as patterns of cycling can vary widely among patients and as patients with cyclical CS do not exhibit unique clinical features compared to those without cycling. Current research suggests that cyclical CS may be present in approximately 15% of adult cases, with an even lower reported prevalence in the pediatric population. Read More

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http://dx.doi.org/10.5114/pedm.2020.95620DOI Listing
January 2020

Obstetric and Neonatal Outcome of Pregnancy in Carney Complex: A Case Report.

Front Endocrinol (Lausanne) 2020 8;11:296. Epub 2020 May 8.

Department of Obstetrics and Gynecology, University Bonn Medical School, Bonn, Germany.

Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome with autosomal dominant inheritance. Affected individuals present with mucocutaneous lentigines/blue nevi, cardiac and noncardiac myxomatous tumors, and multiple endocrine tumors. Mutations in have been identified as genetic cause of the disease. Read More

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http://dx.doi.org/10.3389/fendo.2020.00296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7225262PMC

[Often Only a Side Event, but Sometimes Groundbreaking - an Ectopic ACTH Secretion as an Example of a Paraneoplastic Syndrome].

Praxis (Bern 1994) 2020 ;109(7):517-519

Innere Medizin, Kantonsspital Graubünden, Chur.

Often Only a Side Event, but Sometimes Groundbreaking - an Ectopic ACTH Secretion as an Example of a Paraneoplastic Syndrome Various tumors can cause a paraneoplastic ACTH production, particularly small-cell lung cancers. Patients suffer from a secondary Cushing syndrome with hypokalemia, hypertension, hyperglycemia and edema. There are three therapeutic approaches: treatment of the underlying disease, hormonal inhibition and symptomatic treatment. Read More

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http://dx.doi.org/10.1024/1661-8157/a003433DOI Listing
January 2020

[An Uncommon Cause of Arterial Hypertension].

Praxis (Bern 1994) 2020 ;109(7):513-516

Klinik und Poliklinik für Innere Medizin, Universitätsspital Zürich.

An Uncommon Cause of Arterial Hypertension A 54-year-old patient was suffering from arterial hypertension, which was not treated sufficiently despite an antihypertensive therapy with three different types of drugs. In addition, the patient complained an increase in weight of ten kilos during the last year and a new onset of diabetes mellitus type 2. Investigations as to secondary forms of hypertension by MRI revealed an adrenal tumor with a diameter of approx. Read More

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http://dx.doi.org/10.1024/1661-8157/a003398DOI Listing
January 2020

Etomidate infusion at low doses is an effective and safe treatment for severe Cushing's syndrome outside intensive care.

Eur J Endocrinol 2020 Aug;183(2):161-167

Endocrinology Department, Cliniques Universitaires Saint Luc, Brussels, Belgium.

Introduction: Intravenous etomidate infusion is effective to rapidly lower cortisol levels in severe Cushing's syndrome (CS) in the intensive care unit (ICU). Recently, etomidate treatment has also been proposed at lower doses in non-ICU wards, but it is not yet clear how this approach compares to ICU treatment.

Methods: We compared data from patients with severe CS treated with high starting doses of etomidate (median: 0. Read More

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http://dx.doi.org/10.1530/EJE-20-0380DOI Listing

Megacolon in the context of long-standing Cushing syndrome.

Endocrinol Diabetes Nutr 2020 May 19. Epub 2020 May 19.

Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen del Rocío, Sevilla, España.

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http://dx.doi.org/10.1016/j.endinu.2020.02.004DOI Listing

Cushing's syndrome in pregnancy, diagnosed after delivery.

Yeungnam Univ J Med 2020 May 22. Epub 2020 May 22.

Park Kyung Dae Clinic of Internal Medicine, Gyeongju, Korea.

Cushing's syndrome (CS) is rare in pregnancy, and few cases have been reported to date. Women with untreated CS rarely become pregnant because of the ovulatory dysfunction induced by hypercortisolism. It is difficult to diagnose CS in pregnancy because of its very low incidence, the overlap between the clinical signs of hypercortisolism and the physiological changes that occur during pregnancy and the changes in hypothalamus-pituitary-adrenal axis activity that occur during pregnancy and limit the value of standard diagnostic testing. Read More

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http://dx.doi.org/10.12701/yujm.2020.00290DOI Listing

Different Potent Glucocorticoids, Different Routes of Exposure but The Same Result: Iatrogenic Cushing's syndrome and Adrenal Insufficiency.

Authors:
Ayla Güven

J Clin Res Pediatr Endocrinol 2020 May 20. Epub 2020 May 20.

Health Science University Medical Faculty, Zeynep Kamil Women and Children Hospital, Pediatric Endocrinology Clinic.

Objectives: Potent glucocorticoids (GC) cause iatrogenic Cushing Syndrome (ICS) due to suppression of hypothalamo-hypophyseal-adrenal (HPA) axis and later even adrenal insufficiency (AI). The aim of this study is to review the clinical and laboratory findings of patients with ICS and to demonstrate other serious side effects.

Methods: The possibility of AI was investigated by low-dose ACTH test. Read More

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http://dx.doi.org/10.4274/jcrpe.galenos.2020.2019.0220DOI Listing

Late-Night Salivary Cortisol in Healthy, Community-Dwelling Asian Indians Assessed by Second-Generation ECLIA.

J Clin Endocrinol Metab 2020 Aug;105(8)

Department of Endocrinology & Metabolism, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India.

Background: Late-night salivary cortisol (LNSC) is used as a screening test for Cushing syndrome (CS), but there is no community-derived normative data for the normal upper limit in the South Asian population. This study aimed to determine the upper limit of normal (97.5th percentile) for LNSC in an Asian Indian population using a commercially available second-generation electrochemiluminiscence immunoassay (ECLIA). Read More

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http://dx.doi.org/10.1210/clinem/dgaa269DOI Listing
August 2020
6.209 Impact Factor

Open angle glaucoma secondary to endogenous cortisone due to pituitary microadenoma in a young patient, a case report.

Arch Soc Esp Oftalmol 2020 Jul 15;95(7):353-356. Epub 2020 May 15.

Departamento de Oftalmología, Hospital Puerta de Hierro Majadahonda, Madrid, España; Departamento de Oftalmología, Universidad de Castilla La Mancha, Albacete, España.

Case Report: A 31-year-old male was referred for evaluation after being diagnosed with Cushing syndrome secondary to a pituitary microadenoma. He presented with a reduced visual acuity and high intraocular pressure (IOP) of 48mmHg in both eyes. The examination with biomicroscopy showed normal anterior segment, increased cup to disc ratio, and open angle. Read More

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http://dx.doi.org/10.1016/j.oftal.2020.03.008DOI Listing

Open vs laparoscopic adrenalectomy for localized adrenocortical carcinoma.

Clin Endocrinol (Oxf) 2020 May 18. Epub 2020 May 18.

Department of Endocrinology, University Hospital Centre Zagreb, Zagreb, Croatia.

Objective: The purpose of the study was to compare the long-term outcomes of patients with localized adrenocortical carcinoma (ACC) subjected to open vs laparoscopic surgery.

Design: Retrospective study.

Patients: This retrospective study included 46 patients with the ACC ENSAT stage I-stage III of whom 23 underwent open surgery (OA group), whereas 23 were subjected to laparoscopic adrenalectomy (LA group). Read More

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http://dx.doi.org/10.1111/cen.14251DOI Listing

Cushing syndrome: Old and new genes.

Best Pract Res Clin Endocrinol Metab 2020 Mar 2;34(2):101418. Epub 2020 Apr 2.

Section on Genetics and Endocrinology, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, 20892, MD, USA. Electronic address:

Cushing syndrome (CS) describes the signs and symptoms caused by exogenous or endogenous hypercortisolemia. Endogenous CS is caused by either ACTH-dependent sources (pituitary or ectopic) or ACTH-independent (adrenal) hypercortisolemia. Several genes are currently known to contribute to the pathogenesis of CS. Read More

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http://dx.doi.org/10.1016/j.beem.2020.101418DOI Listing

Prevalence and Incidence of Atrial Fibrillation in a Large Cohort of Adrenal Incidentalomas: A Long-Term Study.

J Clin Endocrinol Metab 2020 Aug;105(8)

Endocrinology and Diabetes Prevention and Care Unit, Department of Medical and Surgical Sciences, University Alma Mater Studiorum of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.

Context: Chronic glucocorticoids excess leads to morphological and functional cardiac alterations, a substrate for arrhythmias. Autonomous cortisol secretion (ACS) in adrenal incidentalomas is a model of chronic endogenous hypercortisolism.

Objective: To investigate prevalence and incidence of atrial fibrillation (AF) in a large cohort of patients with ACS. Read More

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http://dx.doi.org/10.1210/clinem/dgaa270DOI Listing

Ectopic ACTH Secretion in a Child With Metastatic Ewing's Sarcoma: A Case Report.

Front Oncol 2020 28;10:574. Epub 2020 Apr 28.

Department of Paediatric Haematology/Oncology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.

Ectopic ACTH syndrome is rare in pediatric age. Sarcomas that cause Ectopic ACTH Syndrome (EAS) are even more uncommon. Currently, only three cases of EAS caused by Ewing' sarcoma have been reported. Read More

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http://dx.doi.org/10.3389/fonc.2020.00574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7198717PMC

Molecular skin changes in Cushing syndrome and the effects of treatment.

J Endocrinol Invest 2020 May 14. Epub 2020 May 14.

Department of Endocrinology, Yeditepe University Medical School, Istanbul, Turkey.

Objective: We investigated newly diagnosed patients with endogenous CS for molecular changes in skin by biopsy before and a year after treatment of CS.

Patients And Methods: 26 Patients with CS and 23 healthy controls were included. All the patients were evaluated before and a year after treatment. Read More

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http://dx.doi.org/10.1007/s40618-020-01285-7DOI Listing

Bilateral Adrenalectomy: Differences between Cushing Disease and Ectopic ACTH-Producing Tumors.

Ann Surg Oncol 2020 May 9. Epub 2020 May 9.

Department of Surgery, Mayo Clinic, Rochester, MN, USA.

Background: Bilateral adrenalectomy (BA) is a curative treatment for hypercortisolism in patients with corticotropin (ACTH)-dependent Cushing syndrome. Indications include refractory Cushing's disease (CD) following failed pituitary surgery, and occult or unresectable ectopic ACTH-producing neoplasms (EA).

Methods: This was a single-center, retrospective review (1995-2017) of patients undergoing BA for CD or EA. Read More

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http://dx.doi.org/10.1245/s10434-020-08451-4DOI Listing

Comparison of Two High-Throughput Reverse Transcription-Polymerase Chain Reaction Systems for the Detection of Severe Acute Respiratory Syndrome Coronavirus 2.

J Clin Microbiol 2020 May 7. Epub 2020 May 7.

Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has emerged as the cause of a worldwide pandemic. Many commercial SARS-CoV-2 reverse transcription-polymerase chain reaction (RT-PCR) assays have received Emergency Use Authorization from the United States Food and Drug Administration. However, there are limited data describing their performance, in particular the performance of high-throughput SARS-CoV-2 RT-PCR systems. Read More

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http://dx.doi.org/10.1128/JCM.00890-20DOI Listing

ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of Cushing's syndrome.

Eur J Endocrinol 2020 Jul;183(1):G1-G7

Service d'Endocrinologie - Diabète et Nutrition, CHU de Bordeaux, Bordeaux, France.

Clinical evaluation should guide those needing immediate investigation. Strict adherence to COVID-19 protection measures is necessary. Alternative ways of consultations (telephone, video) should be used. Read More

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http://dx.doi.org/10.1530/EJE-20-0352DOI Listing

ARE THERE RELIABLE PREDICTORS FOR THE IMPAIRED QUALITY OF LIFE IN PATIENTS WITH CUSHING'S SYNDROME?

Acta Endocrinol (Buchar) 2019 Oct-Dec;15(4):482-490

Medical University Sofia, Faculty of Medicine - Department of Endocrinology, Sofia, Bulgaria.

Context: Patients with Cushing's syndrome (CS) of any etiology experience a number of physical and psychological symptoms which impact negatively on health-related quality of life (HRQoL).

Subjects And Methods: HRQoL was measured using CushingQoL questionnaire.

Results: The first part of our study was a cross-sectional analysis of 141 patients with CS over a 10-year period. Read More

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http://dx.doi.org/10.4183/aeb.2019.482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7200113PMC

Iatrogenic Cushing's syndrome due to topical steroid abuse in a child with Psoriasis presenting as septicaemia.

Dermatol Ther 2020 May 6:e13514. Epub 2020 May 6.

Department of Dermatology, Venereology and Leprosy, Dr. Ram Manohar Lohia Hospital and Atal Bihari Vajpayee Institute of Medical Sciences, New Delhi, Delhi, India.

Psoriasis vulgaris is a chronic inflammatory disorder that affects the skin and joints. Mild disease is treated with topical corticosteroids (CS) which forms the first line of treatment for localized disease. While it is well established that prolonged use of oral or parenteral corticosteroids can lead to iatrogenic Cushing's syndrome and suppression of hypothalamic pituitary axis; development of these complications secondary to use of topical CS is rarely described. Read More

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http://dx.doi.org/10.1111/dth.13514DOI Listing

Cryptogenic Cushing Syndrome Due to a White Lie.

Clin Chem 2020 May;66(5):658-663

Department of Chemical Pathology, National Health Laboratory Service, University of the Witwatersrand, Johannesburg, South Africa, University of the Witwatersrand, Johannesburg, South Africa.

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http://dx.doi.org/10.1093/clinchem/hvaa035DOI Listing

Commentary on Cryptogenic Cushing Syndrome Due to a White Lie.

Authors:
Stefan K G Grebe

Clin Chem 2020 May;66(5):662-663

Department of Laboratory Medicine and Pathology, Division of Clinical Biochemistry and Immunology, and Department of Medicine, Division of Endocrinology, Mayo Clinic, Rochester, MN.

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http://dx.doi.org/10.1093/clinchem/hvaa037DOI Listing

Commentary on Cryptogenic Cushing Syndrome Due to a White Lie.

Clin Chem 2020 May;66(5):661-662

Department of Internal Medicine III, Technische Universität Dresden, Dresden, Germany.

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http://dx.doi.org/10.1093/clinchem/hvaa036DOI Listing