1,142,294 results match your criteria Current protocols in immunology / edited by John E. Coligan ... [et al.][Journal]


[Current view on obstructive sleep apnea in idiopathic pulmonary fibrosis].

Authors:
Q Y Li A L Song

Zhonghua Yi Xue Za Zhi 2019 Feb;99(6):416-418

Wuxi Branch of Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Wuxi 214000, China.

View Article

Download full-text PDF

Source
http://dx.doi.org/10.3760/cma.j.issn.0376-2491.2019.06.006DOI Listing
February 2019
1 Read

[Pedicled Flaps in the Reconstruction of Complex Wounds at the Lower Extremity].

Z Orthop Unfall 2019 Feb 20;157(1):95-108. Epub 2019 Feb 20.

The present refresher article highlights the current role of pedicled flaps in the reconstruction of complex wounds at the lower extremity. Due to the increasing standardization and ongoing improvements in microsurgery and in view of the fact that local tissue limitation and elevated rates of wound healing disorders reduced the attraction of pedicled flaps to the lower extremity, free flaps became a serious alternative. However, in consideration of the individual patient demand pedicled flaps to the lower extremity still have their eligibility and can be superior to free flaps in selected cases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1055/s-0043-124091DOI Listing
February 2019

Assessing image artifacts from radiotherapy electromagnetic transponders with metal-artifact reduction imaging.

Magn Reson Imaging 2019 Feb 17. Epub 2019 Feb 17.

Department of Physics & Astronomy, University of Manitoba, Canada; Medical Physics, CancerCare Manitoba, Canada.

Image artifacts due to 14 gauge radiotherapy electromagnetic (EM) transponders were assessed on conventional spin echo images, and corrected using metal artifact reduction techniques: high bandwidth, view angle tilting (VAT), and slice encoding for metal artifact correction (SEMAC). Large areas of signal loss and/or pile-up were produced in an area extending up to 15.3 mm in radius for 14G transponders in standard imaging. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.mri.2019.02.005DOI Listing
February 2019

An industry perspective: a streamlined screening strategy using alternative models for chemical assessment of developmental neurotoxicity.

Neurotoxicology 2019 Feb 17. Epub 2019 Feb 17.

Toxicology & Environmental Research and Consulting, The Dow Chemical Company, Midland, Michigan. Electronic address:

Developmental neurotoxicity (DNT) is an important endpoint for the safety assessment of chemicals. However, the current in vivo animal model for DNT assessment is resource-intensive and may not fully capture all mechanisms that may be relevant to DNT in humans. As a result, there is a growing need for more reliable, time- and cost-efficient approaches for DNT evaluation. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.neuro.2019.02.010DOI Listing
February 2019

Using A Developmental Ecology Framework to Align Fear Neurobiology Across Species.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Department of Psychology, Columbia University, New York, NY 10027, USA; email: , , ,

Children's development is largely dependent on caregiving; when caregiving is disrupted, children are at increased risk for numerous poor outcomes, in particular psychopathology. Therefore, determining how caregivers regulate children's affective neurobiology is essential for understanding psychopathology etiology and prevention. Much of the research on affective functioning uses fear learning to map maturation trajectories, with both rodent and human studies contributing knowledge. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-clinpsy-050718-095727DOI Listing
February 2019

History of Psychopharmacology.

Annu Rev Clin Psychol 2019 Feb 20. Epub 2019 Feb 20.

Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California, Los Angeles, California 90095-1759, USA; email:

We live in an age of psychopharmacology. One in six persons currently takes a psychotropic drug. These drugs have profoundly shaped our scientific and cultural understanding of psychiatric disease. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-clinpsy-050718-095514DOI Listing
February 2019

Molecular Interactions Between Plants and Insect Herbivores.

Annu Rev Plant Biol 2019 Feb 20. Epub 2019 Feb 20.

Department of Plant Molecular Biology, University of Lausanne, 1015 Lausanne, Switzerland; email:

Diverse molecular processes regulate the interactions between plants and insect herbivores. Here, we review genes and proteins that are involved in plant-herbivore interactions and discuss how their discovery has structured the current standard model of plant-herbivore interactions. Plants perceive damage-associated and, possibly, herbivore-associated molecular patterns via receptors that activate early signaling components such as Ca, reactive oxygen species, and MAP kinases. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-arplant-050718-095910DOI Listing
February 2019

Mammalian Respiratory Complex I Through the Lens of Cryo-EM.

Annu Rev Biophys 2019 Feb 20. Epub 2019 Feb 20.

Medical Research Council Mitochondrial Biology Unit, University of Cambridge, Cambridge CB2 0XY, United Kingdom; email: , , ,

Single-particle electron cryomicroscopy (cryo-EM) has led to a revolution in structural work on mammalian respiratory complex I. Complex I (mitochondrial NADH:ubiquinone oxidoreductase), a membrane-bound redox-driven proton pump, is one of the largest and most complicated enzymes in the mammalian cell. Rapid progress, following the first 5-Å resolution data on bovine complex I in 2014, has led to a model for mouse complex I at 3. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-biophys-052118-115704DOI Listing
February 2019

International Divergence in Gene Patenting.

Annu Rev Genomics Hum Genet 2019 Feb 20. Epub 2019 Feb 20.

Centre for IT and IP Law, KU Leuven, 3000 Leuven, Belgium.

This review explores the recent divergence in international patent law relating to the patenting of genes and related subject matter. This divergence stems primarily from decisions of the highest courts in the United States and Australia on the eligibility of patent claims relating to the BRCA gene sequences. Patent offices, courts, and policy makers have struggled for many years to clearly articulate the bounds of patent claims on isolated and synthetic DNA and related products and processes, including methods for their use in genetic diagnostics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-genom-083118-015112DOI Listing
February 2019

Alterations in Synovial Fluid Biomarker Levels in Knees With Meniscal Injury as Compared With Asymptomatic Contralateral Knees.

Am J Sports Med 2019 Feb 20:363546519825498. Epub 2019 Feb 20.

Division of Sports Medicine, Department of Orthopaedic Surgery, NYU Langone Health, New York, New York, USA.

Background:: Changes in the joint microenvironment after an injury to the articular surface of the knee have been implicated in the pathogenesis of osteoarthritis. While prior studies focused on changes in this microenvironment after anterior cruciate ligament ruptures, few have explored the biomarker changes that occur in the setting of meniscal injuries.

Purpose:: To determine whether meniscal injury results in significant alterations to synovial fluid biomarker concentrations as compared with noninjured contralateral knees. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1177/0363546519825498DOI Listing
February 2019

Prevention of Opioid Abuse and Treatment of Opioid Addiction: Current Status and Future Possibilities.

Annu Rev Biomed Eng 2019 Feb 20. Epub 2019 Feb 20.

Weldon School of Biomedical Engineering and College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, USA; email:

Prescription opioid medications have seen a dramatic rise in misuse and abuse, leading regulators and scientists to develop policies and abuse-deterrent technologies to combat the current opioid epidemic. These abuse-deterrent formulations (ADFs) are intended to deter physical and chemical tampering of opioid-based products, while still providing safe and effective delivery for therapeutic purposes. Even though formulations with varying abuse-deterrent technologies have been approved, questions remain about their effectiveness. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1146/annurev-bioeng-060418-052155DOI Listing
February 2019

Chromatin-Associated RNA Sequencing (ChAR-seq).

Curr Protoc Mol Biol 2019 Feb 20:e87. Epub 2019 Feb 20.

Department of Biochemistry, Stanford University School of Medicine, Stanford, California.

RNA is a fundamental component of chromatin. Noncoding RNAs (ncRNAs) can associate with chromatin to influence gene expression and chromatin state; many also act at long distances from their transcriptional origin. Yet we know almost nothing about the functions or sites of action for most ncRNAs. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/cpmb.87DOI Listing
February 2019

Current state-of-the-art and future perspectives of the three main modern implant-dentistry concerns: aesthetic requirements, mechanical properties and peri-implantitis prevention.

J Biomed Mater Res A 2019 Feb 20. Epub 2019 Feb 20.

Nanomaterials and Nanotechnology Research Centre (CINN), Consejo Superior de Investigaciones Científicas (CSIC), Universidad de Oviedo (UO), Principado de Asturias (PA), Avenida de la Vega 4-6, 33940 El Entrego, Asturias, Spain.

The idea of permanent tooth replacement goes back to the year 2000 BC at least, when carved bamboo pegs were used to replace missing teeth in ancient China. The phenomenon of osseointegration, however, was not verified until the mid-1960's, when Pr. Branemark discovered that titanium could integrate to bone. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbm.a.36661DOI Listing
February 2019

WSe Photovoltaic Device Based on Intramolecular p-n Junction.

Small 2019 Feb 20:e1805545. Epub 2019 Feb 20.

Key Laboratory of Space Active Opto-Electronics Technology, and State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai, 200083, China.

High quality p-n junctions based on 2D layered materials (2DLMs) are urgent to exploit, because of their unique properties such as flexibility, high absorption, and high tunability which may be utilized in next-generation photovoltaic devices. Based on transfer technology, large amounts of vertical heterojunctions based on 2DLMs are investigated. However, the complicated fabrication process and the inevitable defects at the interfaces greatly limit their application prospects. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/smll.201805545DOI Listing
February 2019

CARDIAC-SPECIFIC OVEREXPRESSION OF CAVEOLIN-3 PRESERVES T-TUBULAR I DURING HEART FAILURE IN MICE.

Exp Physiol 2019 Feb 20. Epub 2019 Feb 20.

School of Physiology, Pharmacology & Neuroscience, Biomedical Sciences Building, University of Bristol, Bristol, BS8 1TD, UK.

New Findings: What is the central question of this study? Overexpression of caveolin-3 (Cav-3 OE) appears to protect the heart against many of the features of heart failure (HF) normally observed in vivo. The present study investigates the cellular basis of this protection. What is the main finding and its importance? Cav-3 OE has little effect in normal ventricular myocytes but reduces cellular hypertrophy and preserves t-tubular I but not local t-tubular Ca release, in HF induced by pressure-overload in mice. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1113/EP087304DOI Listing
February 2019

Coordinating Tissue Regeneration through TGF-β Activated Kinase 1 (TAK1) In-activation and Re-activation.

Stem Cells 2019 Feb 20. Epub 2019 Feb 20.

Department of Surgery, University of Michigan, Ann Arbor, Michigan.

Aberrant wound healing presents as inappropriate or insufficient tissue formation. Using a model of musculoskeletal injury, we demonstrate that loss of TGF-β activated kinase 1 (TAK1) signaling reduces inappropriate tissue formation (heterotopic ossification) through reduced cellular differentiation. Upon identifying increased proliferation with loss of TAK1 signaling, we considered a regenerative approach to address insufficient tissue production through coordinated inactivation of TAK1 to promote cellular proliferation, followed by re-activation to elicit differentiation and extracellular matrix (ECM) production. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/stem.2991DOI Listing
February 2019

Nursing people with intellectual disability and dementia experiencing pain: An integrative review.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

Department of Nursing and Midwifery, University of Limerick, Ireland.

Aim: To explore the current evidence of nurses caring for people with Intellectual Disability and dementia who experience pain.

Background: People with intellectual disability are ageing and are experiencing age related health conditions including dementia and conditions associated with pain, but at an earlier age. Addressing the needs of people with intellectual disability who develop dementia is a new challenge for nurses. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocn.14834DOI Listing
February 2019

Adherence assessment practices in haemodialysis settings: a qualitative exploration of nurses and pharmacists' perspectives.

J Clin Nurs 2019 Feb 20. Epub 2019 Feb 20.

School of Healthcare, University of Leeds, Leeds, United Kingdom.

Aims And Objectives: To explore clinician assessment of patient adherence, and identify strategies to improve adherence assessment practices in haemodialysis settings.

Background: Patients with chronic kidney disease undergoing haemodialysis are typically prescribed complex regimens; as such, they are at high risk of medication nonadherence. Current clinical practices focus on prescribing medications, however, little attention is paid to measuring and ensuring patient adherence to their prescribed treatments. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/jocn.14821DOI Listing
February 2019

Crowdsourcing to delineate skin affected by chronic graft-vs-host disease.

Skin Res Technol 2019 Feb 20. Epub 2019 Feb 20.

Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee.

Background: Estimating the extent of affected skin is an important unmet clinical need both for research and practical management in many diseases. In particular, cutaneous burden of chronic graft-vs-host disease (cGVHD) is a primary outcome in many trials. Despite advances in artificial intelligence and 3D photography, progress toward reliable automated techniques is hindered by limited expert time to delineate cGVHD patient images. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/srt.12688DOI Listing
February 2019

Critical Review of Styrene Genotoxicity Focused on the Mutagenicity/Clastogenicity Literature and Using Current OECD Guidance.

Environ Mol Mutagen 2019 Feb 20. Epub 2019 Feb 20.

Ramboll, 124 West Capitol Avenue, Suite 1605, Little Rock, AR 72201, USA.

Styrene is an important high production volume chemical used to manufacture polymeric products. In 2018, IARC classified styrene as probably carcinogenic to humans; NTP lists styrene as reasonably anticipated to be a human carcinogen. The genotoxicity literature for styrene and its primary metabolite, styrene 7,8-oxide (SO), begins in the 1970s. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/em.22278DOI Listing
February 2019

Anticipating the Era of Dermatology Disease Trackers.

Br J Dermatol 2019 Feb 20. Epub 2019 Feb 20.

University of Arizona, Department of Medicine, Division of Dermatology, Tucson, AZ, USA.

The current era of patient-centered medicine is characterized by widespread accessibility to medical information and self-driven involvement in disease management. This movement is evident in the rapid expansion of medical mobile applications (apps) for personal electronic devices. Between 2014 and 2017, dermatology-specific mobile apps increased by 81% from 291 to 526, with a growing selection of disease tracking apps for various dermatologic conditions. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1111/bjd.17635DOI Listing
February 2019

A Simplified Approach to Reducing Cardiovascular Risk.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

University of New Mexico Health Sciences Center, Department of Internal Medicine, Division of Endocrinology.

Clinical Issue: Cardiovascular disease remains the number one cause of morbidity and mortality in the United States despite major advances in our understanding of its pathogenesis and prevention. One reason for this continued epidemic is the poor adherence to treatment guidelines by caregivers and the lack of understanding by patients relative to its reversibility with treatment. Current guidelines are complex and often contradictory as there are at least 21 organizations publishing guidelines. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02509DOI Listing
February 2019

FEMALE PATTERN HAIR LOSS AND ANDROGEN EXCESS: A REPORT FROM THE MULTIDISCIPLINARY ANDROGEN EXCESS AND PCOS COMMITTEE.

J Clin Endocrinol Metab 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology and Medicine, Duke University Medical Center, Durham, NC, USA.

Objective: To determine the current state of knowledge and provide evidence-based recommendations that could be valid for all specialists taking care of female pattern hair loss (FPHL), a common form of hair loss in women that is characterized by the reduction of hair density in the central area of the scalp, while the frontal hairline is generally well conserved.

Participants: An expert task force appointed by Androgen Excess and PPCOS society, which included specialists from dermatology, endocrinology, and reproductive endocrinology.

Evidence: Levels of evidence were assessed and graded from A to D. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1210/jc.2018-02548DOI Listing
February 2019
1 Read

[Notes for a Psychiatry based on narrations].

Vertex 2018 Sep;XXIX(141):361-367

Servicio de Psiquiatría del Hospital Italiano de Buenos Aires.

In this paper some ideas about the possible relationships between literature and psychiatry are presented. To carry out this task, the work "The initial form: conversations in Princeton" by the argentine writer Ricardo Piglia is analyzed, with the aim of installing a reflection on the current moment of the specialty. Read More

View Article

Download full-text PDF

Source
September 2018

[From treatment-resistant epilepsy to psychosis: Literature review and case report].

Vertex 2018 Sep;XXIX(141):325-329

Universidad de Caen, Francia.

The authors present a case in which they describe the challenges posed by the diagnosis of epileptic patients who suffer a psychotic episode. They also give a detailed account of current practice guidelines in French psychiatry, as well as a discussion regarding the art of everyday clinical practice. Read More

View Article

Download full-text PDF

Source
September 2018

[Sustainable development goals and mental health].

Vertex 2018 Nov;XXIX(142):300-303

Centre for Global Mental Health, King's College London, Institute of Psychiatry.

In 2015, the United Nations Sustainable Development Goals (SDGs) set the course for a more equitable distribution of resources globally. For the first time in history, this collective global commitment explicitly included mental health-related objectives, and manifested them as targets in the health SDG 3. This represents a unique opportunity to increase coverage and quality of services, especially in low- and middle-income countries, in which the current treatment gap surpasses 80% even for the most severe disorders. Read More

View Article

Download full-text PDF

Source
November 2018

Sexual dimorphism of acute doxorubicin-induced nephrotoxicity in C57Bl/6 mice.

PLoS One 2019 20;14(2):e0212486. Epub 2019 Feb 20.

Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota, United States of America.

Doxorubicin (DOX) is a chemotherapeutic agent that has been reported to cause nephrotoxicity in rodent models and to a lesser degree in cancer patients. Female rodents have been shown to be protected against several features of DOX-induced nephrotoxicity. Nevertheless, the underlying mechanisms of this sexual dimorphism are not fully elucidated. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212486PLOS
February 2019

The risk factors for diabetic peripheral neuropathy: A meta-analysis.

PLoS One 2019 20;14(2):e0212574. Epub 2019 Feb 20.

Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education, Department of Toxicology, School of Public Health, Guizhou Medical University, Guiyang, Guizhou, China.

Diabetic peripheral neuropathy (DPN), the most common chronic complication of diabetes, has become an important public health crisis worldwide. Given that DPN is extremely difficult to treat, determining its risk factors and controlling it at an early stage is critical to preventing its serious consequences and the burden of social disease. Current studies suggest that the risk factors for diabetic peripheral neuropathy are the duration of diabetes, age, glycosylated hemoglobin A1c (HbA1c), diabetic retinopathy (DR), smoking, and body mass Index (BMI). Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0212574PLOS
February 2019

An artificial habitat facilitates a climate-mediated range expansion into a suboptimal novel ecosystem.

PLoS One 2019 20;14(2):e0211638. Epub 2019 Feb 20.

Department of Biology, Brigham Young University, Provo, UT.

As the geographic ranges of tropical species and ecosystems continue to shift poleward with climate change, it is critical to prediction and management to identify factors that facilitate these expansions. This is especially true for range shifts that involve the decoupling of a shifting species from its historic ecosystem and the colonization of an ecosystem that it has not previously inhabited (i.e. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211638PLOS
February 2019

Transverse tendon stiffness is reduced in people with Achilles tendinopathy: A cross-sectional study.

PLoS One 2019 20;14(2):e0211863. Epub 2019 Feb 20.

Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, Canada.

Objectives: The objective of the current cross-sectional study was to examine Achilles tendon transverse stiffness in a group of recreational runners with Achilles tendinopathy, in comparison to an asymptomatic group of runners with similar training history. We also aimed to determine the between-week intra-individual reliability of this measurement technique.

Design: Cross-sectional cohort study. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211863PLOS
February 2019

The effect of cycling on cognitive function and well-being in older adults.

PLoS One 2019 20;14(2):e0211779. Epub 2019 Feb 20.

School of Psychology and Clinical Language Sciences, University of Reading, Reading, United Kingdom.

It has been demonstrated that, on their own, both exercise and stimulation from the environment can improve cognitive function and well-being in older adults. The combined effect of exercising in the outdoor environment on psychological function is less well studied. The aim of the current study was to investigate the effect of an outdoor cycling intervention on cognitive function and mental health and well-being in older adults. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211779PLOS
February 2019

Identifying indicators of aesthetics in the Great Barrier Reef for the purposes of management.

PLoS One 2019 20;14(2):e0210196. Epub 2019 Feb 20.

Pollinate, Sydney, New South Wales, Australia.

The aesthetic appreciation of natural places is one of the most fundamental ways in which people relate to their environment. It provides wellbeing, an opportunity for recreation and reflection, a sense of place, and cultural enrichment. It also motivates people to take care of natural places and to conserve them for current and future appreciation. Read More

View Article

Download full-text PDF

Source
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0210196PLOS
February 2019

Hospice UK National Conference 2018.

Int J Palliat Nurs 2019 Feb;25(2):81-90

Patient Services Director, Heart of Kent Hospice.

Foreword Hospice UK's annual conference is the national hospice and palliative care charity's flagship event, bringing together everyone involved in leading hospice, palliative and end-of-life care for adults, children and young people. In 2018, the conference spanned two days and was held at the International Centre in Telford, Shropshire. Its theme was Transforming Palliative Care and it provided a unique forum for delegates to discuss current and forthcoming issues facing the hospice and palliative care community, and to discover new ways of thinking from outside of the sector. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.12968/ijpn.2019.25.2.81DOI Listing
February 2019

Capsaicin causes robust reduction in glycinergic transmission to rat hypoglossal motor neurons via a TRPV1-independent mechanism.

J Neurophysiol 2019 Feb 20. Epub 2019 Feb 20.

Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, Australia.

The effect of capsaicin on glycinergic synaptic transmission to juvenile rat hypoglossal motoneurons in acute brainstem slices was evaluated in the presence of TTX. Capsaicin caused a robust decrease in miniature IPSC frequency, amplitude and half-width, showing that this effect is independent of action potential generation. In the presence of capsazepine, a classic TRPV1 antagonist, capsaicin was still able to reduce spontaneous IPSC amplitude and frequency. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1152/jn.00059.2019DOI Listing
February 2019

Contributions of Rho-kinase and AMP-related kinase (AMPK) Signaling Pathways to Endothelium-Derived Contracting Factors (EDCF)-mediated Responses in Diabetic Rat Aorta.

Can J Physiol Pharmacol 2019 Feb 20. Epub 2019 Feb 20.

Bezmialem Vakif Universitesi, 221265, Faculty of Pharmacy Department of Pharmacology , Bezmialem Vakif University Faculty of Pharmacy , Department of Pharmacology , Maltepe , Istanbul, Turkey , 34093 ;

Diabetes-induced endothelium damage leads to vascular dysfunction. The current study was designed to determine the effects of short-term (4-week) streptozotocin (STZ)-induced diabetes on endothelium-derived contracting factors (EDCF)-mediated responses with possible contributions of Rho-kinase and AMP-activated kinase (AMPK) signaling pathways. The effects of STZ-diabetes on vascular functions were examined in isolated thoracic aorta preparations of 30-week-old rats. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1139/cjpp-2018-0698DOI Listing
February 2019

The activity of transient receptor potential channel C-6 modulates the differentiation of fat cells.

FASEB J 2019 Feb 20:fj201801518RR. Epub 2019 Feb 20.

School of Life Sciences, Faculty of Science, The Chinese University of Hong Kong, Hong Kong, China.

Previously, the V1-3 isoforms of the transient receptor potential channel (TRP) have been shown to promote or prevent adipocyte differentiation. In the current study, the C isoforms were screened for blocking adipogenesis. The hypothesis that the TRP classic or canonical (TRPC) deters adipocyte differentiation was investigated in 3T3-L1 cells employing the channel-specific activator and antagonist, silencing, and overexpression techniques. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1096/fj.201801518RRDOI Listing
February 2019

MoS-Based Optoelectronic Gas Sensor with Sub-Part-per-Billion Limit of NO Gas Detection.

ACS Nano 2019 Feb 20. Epub 2019 Feb 20.

Red light illumination with photon energy matching the direct bandgap of CVD grown single-layer MoS with Au metal electrodes was used to induce a photocurrent which was employed instead of dark current for NO gas sensing. Resulted Au/MoS/Au optoelectronic gas sensor showed a significant enhancement of the device sensitivity S toward ppb level of NO gas exposure reaching S=4.8%/ppb (4800%/ppm), where S is a slope of dependence of relative change of the sensor resistance on NO concentration. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.8b08778DOI Listing
February 2019

Fabrication of SnS/MnSnS/Carbon Heterostructures for Sodium-Ion Batteries with High Initial Coulombic Efficiency and Cycling Stability.

ACS Nano 2019 Feb 22. Epub 2019 Feb 22.

Guangzhou Key Laboratory for Surface Chemistry of Energy Materials, New Energy Research Institute, School of Environment and Energy , South China University of Technology , Guangzhou 510006 , People's Republic of China.

SnS has been extensive studied as an anode material for sodium storage owing to its high theoretical specific capacity, whereas the unsatisfied initial Coulombic efficiency (ICE) caused by the partial irreversible conversion reaction during the charge/discharge process is one of the critical issues that hamper its practical applications. Hence, heterostructured SnS/MnSnS/carbon nanoboxes (SMS/C NBs) have been developed by a facial wet-chemical method and utilized as the anode material of sodium ion batteries. SMS/C NBs can deliver an initial capacity of 841. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1021/acsnano.9b00375DOI Listing
February 2019

Materials and Designs for Wearable Photodetectors.

Adv Mater 2019 Feb 20:e1808138. Epub 2019 Feb 20.

Department of Materials Science, Fudan University, Shanghai, 200433, P. R. China.

Photodetectors (PDs), as an indispensable component in electronics, are highly desired to be flexible to meet the trend of next-generation wearable electronics. Unfortunately, no in-depth reviews on the design strategies, material exploration, and potential applications of wearable photodetectors are found in literature to date. Thus, this progress report first summarizes the fundamental design principles of turning "hard" photodetectors "soft," including 2D (polymer and paper substrate-based devices) and 1D PDs (fiber shaped devices). Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1002/adma.201808138DOI Listing
February 2019

Association of Antipsychotic Polypharmacy vs Monotherapy With Psychiatric Rehospitalization Among Adults With Schizophrenia.

JAMA Psychiatry 2019 Feb 20. Epub 2019 Feb 20.

Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.

Importance: The effectiveness of antipsychotic polypharmacy in schizophrenia relapse prevention is controversial, and use of multiple agents is generally believed to impair physical well-being.

Objective: To study the association of specific antipsychotic combinations with psychiatric rehospitalization.

Design, Setting, And Participants: In this nationwide cohort study, the risk of psychiatric rehospitalization was used as a marker for relapse among 62 250 patients with schizophrenia during the use of 29 different antipsychotic monotherapy and polypharmacy types between January 1, 1996, and December 31, 2015, in a comprehensive, nationwide cohort in Finland. Read More

View Article

Download full-text PDF

Source
http://archpsyc.jamanetwork.com/article.aspx?doi=10.1001/jam
Publisher Site
http://dx.doi.org/10.1001/jamapsychiatry.2018.4320DOI Listing
February 2019
7 Reads

Clinical Features and Comorbidities of Patients With Necrobiosis Lipoidica With or Without Diabetes.

JAMA Dermatol 2019 Feb 20. Epub 2019 Feb 20.

Department of Dermatology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

Importance: Necrobiosis lipoidica (NL) is a rare granulomatous condition. Current knowledge of its key features is based on a limited number of studies and case reports, leading to wide variability in the characterization of its defining features, with limited comparison of patients with or without diabetes.

Objective: To evaluate the epidemiologic characteristics, clinical features, and disease associations of NL in patients with or without type 1 or 2 diabetes. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1001/jamadermatol.2018.5635DOI Listing
February 2019

Lack of evidence of seronegative infection in an endemic area of Chagas disease.

Rev Inst Med Trop Sao Paulo 2019 Feb 14;61:e11. Epub 2019 Feb 14.

Universidade de São Paulo, Instituto de Medicina Tropical de São Paulo, São Paulo, São Paulo, Brazil.

The diagnosis of Chagas disease is based on the detection of Trypanosoma cruzi (T. cruzi)-specific antibodies. Nonetheless, there is concern about the sensitivity of current serological assays due to reports of T. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S1678-9946201961011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376933PMC
February 2019

Death and dying: contributions to a practice based on nursing theoretical frameworks.

Rev Gaucha Enferm 2019 Feb 18;40:e20180139. Epub 2019 Feb 18.

Centro de Investigação em Tecnologias e Serviços de Saúde (CINTESIS). Porto, Portugal.

Objective: To identify nurses' agreement on nursing conceptions with the potential to support their practice in the death and dying process context.

Method: An exploratory and descriptive study with a quantitative approach was carried out with 3,451 nurses from 36 hospitals in Portugal, from July 2015 to March 2016. Data collection was carried out with the use of questionnaires and data analysis was carried out by means of descriptive and inferential statistics. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1983-1447.2019.20180139DOI Listing
February 2019

The latent structure of the Young Schema Questionnaire-Short Form.

Braz J Psychiatry 2019 Feb 18. Epub 2019 Feb 18.

Departamento de Psicologia, Universidade Federal de Pelotas (UFPel), Pelotas, RS, Brazil.

Objective: The current study aimed to examine the latent structure of a web-based, Brazilian Portuguese version of the Young Schema Questionnaire-Short Form (YSQ-SF).

Method: The sample consisted of 15,557 adult participants - 4,702 men and 10,855 women - with age ranging from 18 to 60 years. Confirmatory factor analysis was used to test the a priori conceptual 15-factor model presumed to underlie the YSQ-SF item set. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1516-4446-2018-0261DOI Listing
February 2019

DIGESTIVE DISEASES IN ELDERLY AND FACTORS ASSOCIATED WITH LENGTH OF STAY IN THE HEPATOLOGY AND GASTROENTEROLOGY UNIT OF THE CAMPUS TEACHING HOSPITAL OF LOME (TOGO).

Arq Gastroenterol 2018 Oct-Dec;55(4):369-374

Hepatology and Gastroenterology Unit of the Campus Teaching Hospital of Lome, Togo.

Background: The digestive pathologies are frequent in the elderly and often have a latent and atypical symptomatology.

Objective: To assess the epidemiological and evolutionary current data on digestive diseases in the elderly, and look for factors associated with length of hospital stay.

Methods: Retrospective study of 10 years, including patients aged 60 and over hospitalized for digestive diseases in the Gastroenterology Department of the Campus Teaching Hospital of Lome, Togo. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/S0004-2803.201800000-80DOI Listing

[Access to public physical activity programs in Brazil: National Health Survey, 2013].

Cad Saude Publica 2019 Feb 18;35(2):e00008618. Epub 2019 Feb 18.

Universidade Federal de Pelotas, Pelotas, Brasil.

The article sought to describe awareness of public physical activity programs, practice of physical activity in public programs and barriers related to non-participation in these programs in a national representative sample according to sex, age, skin color, income, state and having been visited by a family health team (EqSF, in Portuguese) in the previous year. This is a cross-sectional survey with data from the Brazilian National Health Survey, 2013. We carried out descriptive analyses using the distribution of relative frequencies and their respective 95% confidence intervals, weighted in the sample design. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/0102-311X00008618DOI Listing
February 2019

Fatty acid composition of vegetable oil blend and in vitro effects of pharmacotherapeutical skin care applications.

Braz J Med Biol Res 2019 Feb 14;52(2):e8209. Epub 2019 Feb 14.

Programa de Pós-Graduação em Ciências Farmacêuticas, Laboratório de Produtos Naturais, Universidade Vila Velha, Vila Velha, ES, Brasil.

Vegetable oils have been used for a plethora of health benefits by their incorporation in foods, cosmetics, and pharmaceutical products, especially those intended for skin care. This study aimed to investigate the cutaneous benefits of a vegetable oil blend (VOB) formulation and its fatty acid composition. The anti-inflammatory activity was studied in macrophages of RAW 264. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1590/1414-431X20188209DOI Listing
February 2019

Electrochemical flow cell enabling operando probing of electrocatalyst surfaces by X-ray spectroscopy and diffraction.

Phys Chem Chem Phys 2019 Feb 20. Epub 2019 Feb 20.

Joint Center for Artificial Photosynthesis, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. and Chemical Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA.

The rational improvement of current and developing electrochemical technologies requires atomistic understanding of electrode-electrolyte interfaces. However, examining these interfaces under operando conditions, where performance is typically evaluated and benchmarked, remains challenging, as it necessitates incorporating an operando probe during full electrochemical operation. In this study, we describe a custom electrochemical flow cell that enables near-surface-sensitive operando investigation of planar thin-film catalysts at significant hydrogen evolution reaction (HER) rates (in excess of -100 mA cm-2) using grazing incidence X-ray methods. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.1039/c8cp07423bDOI Listing
February 2019

Evaluating Information Quality of Revised Patient Education Information on Colonoscopy: It Is New But Is It Improved?

Interact J Med Res 2019 Feb 20;8(1):e11938. Epub 2019 Feb 20.

Inflammatory Bowel Disease Clinical and Research Centre, University of Manitoba, Winnipeg, MB, Canada.

Background: Previous research indicates that patients and their families have many questions about colonoscopy that are not fully answered by existing resources. We developed revised forms on colonoscopy bowel preparation and on the procedure itself.

Objective: As the goal of the revised materials is to have improved information relative to currently available information, we were interested in how revised information compared with what is currently available in terms of information quality and patient preference. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2196/11938DOI Listing
February 2019

Use of Mobile and Computer Devices to Support Recovery in People With Serious Mental Illness: Survey Study.

JMIR Ment Health 2019 Feb 20;6(2):e12255. Epub 2019 Feb 20.

Westat, Inc, Lebanon, NH, United States.

Background: Mental health recovery refers to an individual's experience of gaining a sense of personal control, striving towards one's life goals, and meeting one's needs. Although people with serious mental illness own and use electronic devices for general purposes, knowledge of their current use and interest in future use for supporting mental health recovery remains limited.

Objective: This study aimed to identify smartphone, tablet, and computer apps that mental health service recipients use and want to use to support their recovery. Read More

View Article

Download full-text PDF

Source
http://dx.doi.org/10.2196/12255DOI Listing
February 2019
  • Page 1 of 22846