1,158,137 results match your criteria Current protocols in immunology / edited by John E. Coligan ... [et al.][Journal]


Organic or conventional dairy farming in northern Spain: impacts on cow reproductive performance.

Reprod Domest Anim 2019 Apr 21. Epub 2019 Apr 21.

Universidade de Santiago de Compostela, Departamento de Patoloxía Animal, Facultade de Veterinaria, 27002, Lugo, Spain.

Organic farming has traditionally given preference to indigenous breeds that are well adapted to local conditions; however, current trends towards increased yields may produce less robust animals with potentially low fertility. The Holstein-Friesian breed dominates dairy sector, although there is a general concern that these cows may not be well adapted to organic systems. This study aims to evaluate the reproductive performance of organic dairy herds in northern Spain, by comparing organically-reared Holstein-Friesian with their counterparts reared on conventional farms and also with other organically reared breeds and crosses. Read More

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http://dx.doi.org/10.1111/rda.13446DOI Listing

Dermoscopy of Pagetoid reticulosis, with dermoscopic-pathologic correlation.

Photodermatol Photoimmunol Photomed 2019 Apr 21. Epub 2019 Apr 21.

First Dermatology Department, Aristotle University of Thessaloniki, Greece.

Pagetoid reticulosis (PR), also known as Woringer-Kolopp disease, is a rare variant of mycosis fungoides with distinctive clinicopathologic features. It clinically manifests as a solitary, erythematous, gradually enlarging, scaly or verrucous plaque on the lower extremities, and due to its indolent course and non-specific clinical features, may remain undiagnosed for years. In the current we describe the clinical and dermoscopic characteristics of a rare case of PR disease, and correlate them with the corresponding histopathologic findings. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/phpp.12472
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http://dx.doi.org/10.1111/phpp.12472DOI Listing
April 2019
4 Reads

Incretin-based Therapies for the Management of NAFLD in Patients with Type 2 Diabetes.

Authors:
Kenneth Cusi

Hepatology 2019 Apr 21. Epub 2019 Apr 21.

Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, FL.

The prevalence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetes (T2DM) is believed to be ~70% and that of advanced fibrosis ~20%. Given the magnitude of the problem, there is a real sense of urgency to identify the best pharmacological approach for to treat both diabetes and NASH in this population. Vitamin E is recommended for patients with biopsy-proven NASH without diabetes but did not have similar efficacy in a recent proof-of-concept RCT in patients with T2DM. Read More

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http://dx.doi.org/10.1002/hep.30670DOI Listing

Testosterone deficiency in men with Type 2 diabetes: pathophysiology and treatment.

Diabet Med 2019 Apr 21. Epub 2019 Apr 21.

Department of Medicine Austin Health, University of Melbourne.

Epidemiological studies consistently demonstrate that lowered serum testosterone is not only common in men with established Type 2 diabetes, but also predicts future diabetic risks and increased mortality. Preclinical studies report plausible mechanisms by which low testosterone could mediate dysglycaemia. Exogenous testosterone treatment consistently reduces fat mass, increases muscle mass and improves insulin resistance in some studies, but the majority of currently available randomized controlled trials (RCTs) do not report a consistent glycaemic benefit. Read More

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http://dx.doi.org/10.1111/dme.13977DOI Listing

Rainfall exclusion and thinning can alter the relationships between forest functioning and drought.

New Phytol 2019 Apr 21. Epub 2019 Apr 21.

CEFE CNRS, 1919 route de Mende, 34293, Montpellier, Cedex 5.

Increasing drought caused by the on-going climate change, and forest management by thinning that aims at mitigating its impact, may modify the current relationships between forest functions and drought intensity and preclude our ability to forecast future ecosystem responses. We used 15 years of data from an experimental rainfall exclusion (-27% of rainfall) combined with thinning (-30% stand basal area) to investigate differences in the drought-functioning relationships for each component of aboveground net primary productivity (ANPP) and stand transpiration in a Mediterranean Quercus ilex stand. Rainfall exclusion reduced stand ANPP by 10%, mainly because of lowered leaf and acorn production, while wood production remained unaffected. Read More

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https://onlinelibrary.wiley.com/doi/abs/10.1111/nph.15860
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http://dx.doi.org/10.1111/nph.15860DOI Listing
April 2019
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Haloperidol discontinuation for people with schizophrenia.

Cochrane Database Syst Rev 2019 Apr 21;4:CD011408. Epub 2019 Apr 21.

Community Mental Health, Counties Manukau Health, Building 6, 17 Lambie Drive,, Manukau, Auckland, New Zealand, 2241.

Background: Schizophrenia is a disabling serious mental illness that can be chronic. Haloperidol, one of the first generation of antipsychotic drugs, is effective in the treatment of schizophrenia but can have adverse side effects. The effects of stopping haloperidol in people with schizophrenia who are stable on their prescription are not well researched in the context of systematic reviews. Read More

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http://dx.doi.org/10.1002/14651858.CD011408.pub2DOI Listing
April 2019
1 Read

M51R and Delta-M51 matrix protein of the vesicular stomatitis virus induce apoptosis in colorectal cancer cells.

Mol Biol Rep 2019 Apr 20. Epub 2019 Apr 20.

Cell and Molecular Research center, Golestan University of Medical Science, 1 Shastcola Ave, 5 km Sari Rd, Gorgan, Iran.

Colorectal cancer (CRC) is the third most common cancer in both men and women. Oncolytic viral-based therapy methods seem to be promising for CRC treatment. Vesicular stomatitis virus (VSV) is considered as a potent candidate in viral therapy for several tumors. Read More

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http://dx.doi.org/10.1007/s11033-019-04799-3DOI Listing

Pharmacovigilance Systems in Arab Countries: Overview of 22 Arab Countries.

Drug Saf 2019 Apr 20. Epub 2019 Apr 20.

College of Pharmacy, Department of Clinical Pharmacy, University of Hail, P.O. Box 6166, Hail, 81442, Saudi Arabia.

Pharmacovigilance has received much attention in Arab countries recently due to the development of new regulations. However, there are differences in the progression of pharmacovigilance systems by regulatory agencies in these countries because only some are able to meet the requirements for conducting pharmacovigilance activities. Only 45% of Arab countries are official members of the World Health Organization (WHO) Collaborating Centre for International Drug Monitoring. Read More

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http://link.springer.com/10.1007/s40264-019-00807-4
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http://dx.doi.org/10.1007/s40264-019-00807-4DOI Listing
April 2019
3 Reads

A Genome-Wide Association Study of Bisphosphonate-Associated Atypical Femoral Fracture.

Calcif Tissue Int 2019 Apr 20. Epub 2019 Apr 20.

Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Atypical femoral fracture is a well-documented adverse reaction to bisphosphonates. It is strongly related to duration of bisphosphonate use, and the risk declines rapidly after drug withdrawal. The mechanism behind bisphosphonate-associated atypical femoral fracture is unclear, but a genetic predisposition has been suggested. Read More

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http://dx.doi.org/10.1007/s00223-019-00546-9DOI Listing

On prognostic estimates of radiation risk in medicine and radiation protection.

Radiat Environ Biophys 2019 Apr 20. Epub 2019 Apr 20.

Department of Physics, Science Faculty, University of Zürich, Winterthurerstrasse 190, 8057, Zurich, Switzerland.

The problem of expressing cumulative detrimental effect of radiation exposure is revisited. All conventionally used and computationally complex lifetime or time-integrated risks are based on current population and health statistical data, with unknown future secular trends, that are projected far into the future. It is shown that application of conventionally used lifetime or time-integrated attributable risks (LAR, AR) should be limited to exposures under 1 Gy. Read More

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http://dx.doi.org/10.1007/s00411-019-00794-1DOI Listing

Association of changes in bone mineral parameters with mortality in haemodialysis patients: insights from the ARO cohort.

Nephrol Dial Transplant 2019 Apr 21. Epub 2019 Apr 21.

Department of Nephrology, Division of Nephrology and Clinical Immunology, RWTH University of Aachen, Aachen, Germany.

Background: There is little information in haemodialysis (HD) patients on whether temporal changes in serum calcium, phosphate or intact parathyroid hormone (iPTH) are associated with mortality.

Methods: We analysed associations of phosphate, total calcium and iPTH with all-cause and cardiovascular mortality in 8817 incident HD patients from the European second Analyzing Data, Recognizing Excellence and Optimizing Outcomes (AROii) cohort enrolled in 2007-09, which were prospectively followed for a median of 3 years, using time-dependent Cox proportional hazards models. We evaluated changes in risk over time depending on changes in phosphate, calcium or iPTH. Read More

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https://academic.oup.com/ndt/advance-article/doi/10.1093/ndt
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http://dx.doi.org/10.1093/ndt/gfz060DOI Listing
April 2019
1 Read

Next-generation reference intervals for pediatric hematology.

Clin Chem Lab Med 2019 Apr 22. Epub 2019 Apr 22.

Department of Pediatrics and Adolescent Medicine, University Hospital Erlangen, Erlangen, Germany.

Background Interpreting hematology analytes in children is challenging due to the extensive changes in hematopoiesis that accompany physiological development and lead to pronounced sex- and age-specific dynamics. Continuous percentile charts from birth to adulthood allow accurate consideration of these dynamics. However, the ethical and practical challenges unique to pediatric reference intervals have restricted the creation of such percentile charts, and limitations in current approaches to laboratory test result displays restrict their use when guiding clinical decisions. Read More

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http://dx.doi.org/10.1515/cclm-2018-1236DOI Listing

Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol.

BMJ Open 2019 Apr 20;9(4):e028444. Epub 2019 Apr 20.

The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada.

Introduction: People living with HIV (PLWH) on antiretroviral therapy (ART) do not progress to AIDS. However, they still suffer from an increased risk of inflammation-associated complications. HIV persists in long-lived CD4+ T cells, which form the major viral reservoir. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-028444DOI Listing

Oral anticoagulation therapy use in patients with atrial fibrillation after the introduction of non-vitamin K antagonist oral anticoagulants: findings from the French healthcare databases, 2011-2016.

BMJ Open 2019 Apr 20;9(4):e026645. Epub 2019 Apr 20.

University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team Pharmacoepidemiology - UMR 1219, Bordeaux, France.

Objectives: To describe (i) the trend in oral anticoagulant (OAC) use following the introduction of non-vitamin K antagonist oral anticoagulant (NOAC) therapy for stroke prevention in atrial fibrillation (AF) patients and (ii) the current patterns of use of NOAC therapy in new users with AF in France.

Design: (i) Repeated cross-sectional study and (ii) population-based cohort study.

Setting: French national healthcare databases (50 million beneficiaries). Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026645DOI Listing

International prospective observational study on intracranial pressure in intensive care (ICU): the SYNAPSE-ICU study protocol.

BMJ Open 2019 Apr 20;9(4):e026552. Epub 2019 Apr 20.

Department of Public Health, Erasmus MC, Rotterdam, Netherlands.

Introduction: Intracranial pressure (ICP) monitoring is commonly used in neurocritical care patients with acute brain injury (ABI). Practice about indications and use of ICP monitoring in patients with ABI remains, however, highly variable in high-income countries, while data on ICP monitoring in low and middle-income countries are scarce or inconsistent. The aim of the SYNAPSE-ICU study is to describe current practices of ICP monitoring using a worldwide sample and to quantify practice variations in ICP monitoring and management in neurocritical care ABI patients. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-026552DOI Listing
April 2019
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Pathways and associated costs of care in patients with confirmed and presumptive tuberculosis in Tanzania: A cross-sectional study.

BMJ Open 2019 Apr 20;9(4):e025079. Epub 2019 Apr 20.

Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.

Objective: To assess pathways and associated costs of seeking care from the onset of symptoms to diagnosis in patients with confirmed and presumptive tuberculosis (TB).

Design: Cross-sectional study.

Setting: District hospital in Dar es Salaam, Tanzania. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02507
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http://dx.doi.org/10.1136/bmjopen-2018-025079DOI Listing
April 2019
1 Read

Serogroup-specific meningococcal carriage by age group: a systematic review and meta-analysis.

BMJ Open 2019 Apr 20;9(4):e024343. Epub 2019 Apr 20.

Sanofi Pasteur, Inc., Swiftwater, Pennsylvania, USA.

Objective: carriage prevalence has known variation across the lifespan, but it is unclear whether carriage varies among meningococcal capsular groups. Therefore, we aimed to characterise group-specific meningococcal carriage by age group and world region from 2007 to 2016.

Design: Systematic review and meta-analysis. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-024343DOI Listing

Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study.

BMJ Open 2019 Apr 20;9(4):e024210. Epub 2019 Apr 20.

Division of Population Medicine, School of Medicine, Wales Centre for Primary and Emergency Care Research (PRIME Centre Wales), Cardiff University, Cardiff, UK.

Introduction: Current guidelines advise the prompt diagnosis and treatment of urinary tract infection (UTI) in children to improve both short and longer term outcomes. However, the risk of long-term complications following childhood UTI is unclear.UTI is relatively common but difficult to diagnose in children as symptoms are non-specific. Read More

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http://bmjopen.bmj.com/lookup/doi/10.1136/bmjopen-2018-02421
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http://dx.doi.org/10.1136/bmjopen-2018-024210DOI Listing
April 2019
1 Read

Exploring the clinical context of adopting an instrumented insole: a qualitative study of clinicians' preferences in England.

BMJ Open 2019 Apr 20;9(4):e023656. Epub 2019 Apr 20.

Department of Surgery and Cancer, Imperial College London, London, UK.

Objectives: This study explores clinicians' views of the clinical uptake of a smart pressure-sensing insole, named Flexifoot, to enhance the care and management of patients with osteoarthritis (OA). Clinicians are key users of wearable technologies, and can provide appropriate feedback for a specific device for successful clinical implementation.

Design: Qualitative study with in-depth, semi-structured interviews, analysed using inductive analysis to generate key themes. Read More

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http://dx.doi.org/10.1136/bmjopen-2018-023656DOI Listing

Molecular signature characterisation of different inflammatory phenotypes of systemic juvenile idiopathic arthritis.

Ann Rheum Dis 2019 Apr 20. Epub 2019 Apr 20.

Department of Paediatric Rheumatology and Immunology, University of Münster, Münster, Germany

Objectives: The International League of Associations for Rheumatology classification criteria define systemic juvenile idiopathic arthritis (SJIA) by the presence of fever, rash and chronic arthritis. Recent initiatives to revise current criteria recognise that a lack of arthritis complicates making the diagnosis early, while later a subgroup of patients develops aggressive joint disease. The proposed biphasic model of SJIA also implies a 'window of opportunity' to abrogate the development of chronic arthritis. Read More

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http://ard.bmj.com/lookup/doi/10.1136/annrheumdis-2019-21505
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http://dx.doi.org/10.1136/annrheumdis-2019-215051DOI Listing
April 2019
1 Read

Heated tobacco products use in Chinese adults in Hong Kong: a population-based cross-sectional study.

Tob Control 2019 Apr 20. Epub 2019 Apr 20.

School of Public Health, The University of Hong Kong, Hong Kong, China.

Introduction: We investigated heated tobacco products (HTPs) use and associated factors in Chinese adults in Hong Kong where HTPs are not formally marketed yet, and cigarette smoking prevalence was the lowest in the developed world.

Methods: A population-based landline telephone survey in 2017 interviewed 5131 (45.2% male; 26. Read More

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http://tobaccocontrol.bmj.com/lookup/doi/10.1136/tobaccocont
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http://dx.doi.org/10.1136/tobaccocontrol-2018-054719DOI Listing
April 2019
1 Read

Theoretical study of the cis-pinonic acid and its atmospheric hydrolysate participation in the atmospheric nucleation.

Sci Total Environ 2019 Apr 1;674:234-241. Epub 2019 Apr 1.

Environment Research Institute, Shandong University, Jinan 250100, PR China.

cis-Pinonic acid (CPA), one of the major photooxidation products of α-pinene, is believed to contribute to the formation of aerosols formed over forested areas. In the current study, we implement quantum chemical calculation to investigate the interaction between sulfuric acid (SA) and CPA as well as the hydrolysate of CPA (HCPA) in the presence of water or ammonia in the atmosphere. The lowest free energy configurations, reactants, transition states, intermediates, and products were optimized at 298/278 K and 1 atm at the M06-2X/6-311+G(3df,3pd) level. Read More

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http://dx.doi.org/10.1016/j.scitotenv.2019.03.479DOI Listing

24-Epibrassinolide alters DNA cytosine methylation of Linum usitatissimum L. under salinity stress.

Plant Physiol Biochem 2019 Apr 13;139:478-484. Epub 2019 Apr 13.

Institute of Biotechnology, Urmia University, Urmia, Iran; Department of Plant Breeding and Biotechnology, Faculty of Agriculture, Urmia University, Urmia, Iran.

Salinity is a common environmental challenge limiting worldwide agricultural crop yield. Plants employ epigenetic regulatory strategies, such as DNA methylation which relatively allows rapid adaptation to new conditions in response to environmental stresses. Brassinosteroids (BRs) are a novel group of phytohormones recognized as transcription and translation regulators which are able to mitigate the impact of environmental stresses on the plants. Read More

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http://dx.doi.org/10.1016/j.plaphy.2019.04.010DOI Listing

Beam brightness and its reduction in a 1.2-MV cold field-emission transmission electron microscope.

Ultramicroscopy 2019 Apr 11;202:107-113. Epub 2019 Apr 11.

Center for Exploratory Research, Research & Development Group, Hitachi, Ltd. Hatoyama, Saitama 350-0395, Japan.

In this paper we discuss probe properties in terms of probe currents, probe sizes, energy spread, virtual source sizes, and brightness in a 1.2-MV cold field-emission (cold FE) transmission electron microscope (TEM) equipped with a magnetic gun lens. The probe size increased gradually in proportion to the (3/8)th power of the probe current, very unusual behavior in cold FE guns but typical behavior in thermionic guns. Read More

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http://dx.doi.org/10.1016/j.ultramic.2019.04.002DOI Listing

Mechanical properties of bovine erythrocytes derived from ion current measurements using micropipettes.

Bioelectrochemistry 2019 Apr 13;128:204-210. Epub 2019 Apr 13.

The MacDiarmid Institute for Advanced Materials and Nanotechnology, New Zealand; Department of Physics, The University of Auckland, New Zealand; School of Chemical Sciences, The University of Auckland, New Zealand. Electronic address:

Synchronized data from ion currents and optical microscopy have been used to measure the mechanical properties of individual soft microparticles. This new experimental method draws on the signals generated by each particle as it passes through the tip of a pipette. The technique represents an advance on micropipette aspiration (MA), which uses optical microscopy in isolation. Read More

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http://dx.doi.org/10.1016/j.bioelechem.2019.04.013DOI Listing

Teratogenic potential of third-generation antiepileptic drugs: Current status and research needs.

Pharmacol Rep 2019 Jan 31;71(3):491-502. Epub 2019 Jan 31.

Neurobiology Lab, Department of Zoology, University of Allahabad, Allahabad, India. Electronic address:

The aim of this review was to scrutinize the current literature available on teratogenic safety of third-generation antiepileptic drugs (TGAEDs) considering their clinical implications and to highlight for further research need in the interest of the diseased population in general and women with epilepsy in particular. For evaluation of the teratogenic potential of TGAEDs, this review summarized the existing information on controlled clinical trials conducted by the pharmaceutical companies, case reports, scholarly articles (prospective and retrospective studies), and experimental tests carried out so far. Firstly, clinical reports have reviewed on each drug followed by non-clinical studies reported hitherto. Read More

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http://dx.doi.org/10.1016/j.pharep.2019.01.011DOI Listing
January 2019

Neuroticism and chronicity as predictors of 9-year course of individual depressive symptoms.

J Affect Disord 2019 Apr 15;252:484-492. Epub 2019 Apr 15.

Department of Psychiatry, Leiden University Medical Center, PO Box 9600, 2300 RC, Leiden, the Netherlands.

Background: The large between-person differences in symptomatology suggest that major depressive disorder (MDD) is a heterogeneous psychiatric disorder. However, symptom-specific prospective studies are scarce. We hypothesized that chronicity (i. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.052DOI Listing

Pilot trial of home-administered transcranial direct current stimulation for the treatment of depression.

J Affect Disord 2019 Apr 10;252:475-483. Epub 2019 Apr 10.

School of Psychiatry, University of New South Wales/Black Dog Institute, Hospital Road, Randwick, NSW 2031, Australia; St George Hospital, South Eastern Sydney Health, Level 2, James Laws House, Gray St, Kogarah, NSW 2217, Australia.

Background: Transcranial Direct Current Stimulation (tDCS) is a non-invasive, neuromodulation approach with promising efficacy for treating depression. To date, tDCS has been limited to clinical or research centre settings with treatment administered by staff. The aim of this study is to examine the efficacy, tolerability and feasibility of home-administered, remotely-supervised tDCS for depression. Read More

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http://dx.doi.org/10.1016/j.jad.2019.04.041DOI Listing

Geniposide, a sonic hedgehog signaling inhibitor, inhibits the activation of hepatic stellate cell.

Int Immunopharmacol 2019 Apr 18;72:330-338. Epub 2019 Apr 18.

Department of Pharmacy, The Second Affiliated Hospital Of Bengbu Medical College, Hongye Road, Bengbu 233000, China. Electronic address:

Liver fibrosis is a continuous wound-healing process, which is due to excessive deposition of extracellular matrix (ECM) caused by activated Hepatic Stellate Cells (HSCs). Geniposide (GP) is a naturally occurring iridoid glucoside and is extracted from Gardenia jasminoides Ellis. GP has long been speculated to play a vital role in the treatment of hyperlipidemia and fatty liver. Read More

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http://dx.doi.org/10.1016/j.intimp.2019.04.016DOI Listing

An FPSE-HPLC-PDA method for rapid determination of solar UV filters in human whole blood, plasma and urine.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 16;1118-1119:40-50. Epub 2019 Apr 16.

International Forensic Research Institute, Department of Chemistry and Biochemistry, Florida International University, Miami, FL, USA. Electronic address:

This paper reports a novel fabric phase sorptive extraction-high performance liquid chromatography-photodiode array detection (FPSE-HPLC-PDA) method for the simultaneous extraction and analysis of six benzophenone derivative UV filters including benzophenone (BZ); 5-benzoyl-4-hydroxy-methoxybenzenesulfonic acid (BP-4); bis(4-hydroxyphenyl)methanone (4-DHB); bis(2,4-dihydroxyphenyl)methanone (BP-2); (2,4-dihydroxybenzophenone) (BP-1) and 2,2'-dihydroxy-4-methoxybenzophenone (DHMB) in human whole blood, plasma and urine samples. Chromatographic separation method was conducted using a Spherisorb ODS 1 (C) column in isocratic elution mode with a run time <25 min. The FPSE-HPLC-PDA method was validated in the range from 0. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.028DOI Listing

Untargeted gas chromatography-mass spectrometry-based metabolomics analysis of kidney and liver tissue from the Lewis Polycystic Kidney rat.

J Chromatogr B Analyt Technol Biomed Life Sci 2019 Apr 12;1118-1119:25-32. Epub 2019 Apr 12.

Separation Science and Metabolomics Laboratory, Murdoch University, 90 South Street, Murdoch, WA 6150, Australia; Metabolomics Australia, Western Australia Node, Murdoch University, 90 South Street, Murdoch, WA 6150, Australia.

Polycystic kidney disease (PKD) encompasses a spectrum of inherited disorders that lead to end-stage renal disease (ESRD). There is no cure for PKD and current treatment options are limited to renal replacement therapy and transplantation. A better understanding of the pathobiology of PKD is needed for the development of new, less invasive treatments. Read More

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http://dx.doi.org/10.1016/j.jchromb.2019.04.021DOI Listing

Diabetic retinopathy, a vascular and inflammatory disease: therapeutic implications.

Diabetes Metab 2019 Apr 18. Epub 2019 Apr 18.

Department of Medicine and Health Sciences 'V. Tiberio', University of Molise, Via Francesco De Sanctis 1, 86100 Campobasso, Italy. Electronic address:

Diabetic retinopathy (DR) is the most common microvascular complication of diabetes and the leading cause of visual impairment in the working-age population in the Western world. Diabetic macular oedema (DME) is one of the major complications of DR. Therapy with intravitreal injections of anti-vascular endothelial growth factor (anti-VEGF) drugs has become the gold standard treatment for DR and its complications. Read More

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http://dx.doi.org/10.1016/j.diabet.2019.04.002DOI Listing

Toward high-resolution in situ structural biology with cryo-electron tomography and subtomogram averaging.

Authors:
Florian Km Schur

Curr Opin Struct Biol 2019 Apr 18;58:1-9. Epub 2019 Apr 18.

Institute of Science and Technology Austria, Am Campus 1, A-3400 Klosterneuburg, Austria. Electronic address:

Cryo-electron tomography (cryo-ET) provides unprecedented insights into the molecular constituents of biological environments. In combination with an image processing method called subtomogram averaging (STA), detailed 3D structures of biological molecules can be obtained in large, irregular macromolecular assemblies or in situ, without the need for purification. The contextual meta-information these methods also provide, such as a protein's location within its native environment, can then be combined with functional data. Read More

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http://dx.doi.org/10.1016/j.sbi.2019.03.018DOI Listing

Ring and bring drug services: Delivery dealing and the social life of a drug phone.

Int J Drug Policy 2019 Apr 18;69:8-15. Epub 2019 Apr 18.

Centre for Alcohol and Drug Research, Aarhus University, Denmark. Electronic address:

Background: Illegal drug dealers no longer compete for customers only through the quality of their products, but also in convenience and speed of delivery. This article investigates "ring and bring" drug dealing, and argues that a focus on dealers' use of mobile phones is useful for exploring current changes within retail level drug markets.

Methods: The article is based on 21 face-to-face in-depth interviews with active drug dealers in Denmark all of whom were involved in the delivery of drugs (mainly cannabis and cocaine) often to buyers' homes. Read More

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http://dx.doi.org/10.1016/j.drugpo.2019.02.003DOI Listing

Natural products as a perspective for cancer pain management: A systematic review.

Phytomedicine 2018 Nov 22;58:152766. Epub 2018 Nov 22.

Departamento de Fisiologia, Laboratório de Neurociências e Ensaios Farmacológicos (LANEF). Universidade Federal de Sergipe, São Cristovão, Sergipe, Brazil.

Background: Cancer is the leading cause of death in the world and one of the main symptoms affecting these individuals is chronic pain, which must be evaluated and treated in its various components. Several drugs are currently used, but beyond the high cost, they have harmful side effects to patients or are transitorily effective. Ergo, there is a need to look for new options for cancer pain relief. Read More

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http://dx.doi.org/10.1016/j.phymed.2018.11.026DOI Listing
November 2018

Wound dressing properties of cationized cotton fabric treated with carrageenan/cyclodextrin hydrogel loaded with honey bee propolis extract.

Int J Biol Macromol 2019 Apr 18. Epub 2019 Apr 18.

Pre-Treatment and Finishing of Cellulosic Fabric Department, Textile Research Division, National Research Center, 33 El-Behooth St, Dokki, Giza 12311, Egypt. Electronic address:

The current study was set to prepare a delivery system based on a mixture of biodegradable polymeric hydrogel (i.e., carrageenan (κ-CAR) and β-cyclodextrin (β-CD)) for encapsulating honey bee propolis extract (HBP). Read More

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http://dx.doi.org/10.1016/j.ijbiomac.2019.04.065DOI Listing

Joint toxic effects of cadmium and four pesticides on the earthworm (Eisenia fetida).

Chemosphere 2019 Apr 13;227:489-495. Epub 2019 Apr 13.

State Key Laboratory Breeding Base for Zhejiang Sustainable Pest and Disease Control / Key Laboratory for Pesticide Residue Detection of Ministry of Agriculture / Laboratory (Hangzhou) for Risk Assessment of Agricultural Products of Ministry of Agriculture, Institute of Quality and Standard for Agro-products, Zhejiang Academy of Agricultural Sciences, Hangzhou, 310021, Zhejiang, China.

The contaminants, instead of single contaminants, are usually found as chemical mixtures in terrestrial environment. However, little information is now available about the joint effects of heavy metals and farm chemicals on the soil organism. Our current study aimed to assess the combined toxicity of cadmium (Cd) and four pesticides (atrazine, chlorpyrifos, lambda-cyhalothrin and abamectin) to the earthworm (Eisenia fetida) with binary, ternary, quaternary and quinquenary mixtures. Read More

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http://dx.doi.org/10.1016/j.chemosphere.2019.04.064DOI Listing
April 2019
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The CCL2 elevation in primary afferent fibers produces zymosan-induced hyperalgesia through microglia-mediated neuronal activation in the spinal dorsal horn.

Brain Res Bull 2019 Apr 18. Epub 2019 Apr 18.

Department of Pharmacology, Institute for Medical Science, Chonbuk National University Medical School, Jeonju, 54907, Republic of Korea. Electronic address:

Although C-C motif chemokine ligand 2 (CCL2) plays a critical role in the pathogenesis of neuropathic pain through neuron-microglia interactions, its pronociceptive function underlying inflammatory pain remains to be fully understood. The present study aimed to elucidate the potential role of CCL2 in pain sensitization following zymosan-induced inflammation. Intraplantar injection of zymosan into the rat hind paw significantly increased the expression of CCL2 in both dorsal root ganglions and the superficial dorsal horn. Read More

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http://dx.doi.org/10.1016/j.brainresbull.2019.04.014DOI Listing

Role of multidimensional assessment of frailty in predicting outcomes in elderly glioblastoma patients treated with adjuvant concurrent chemo-radiation.

J Geriatr Oncol 2019 Apr 17. Epub 2019 Apr 17.

Radiation Oncology Unit, AUSL - IRCCS di Reggio Emilia, Italy.. Electronic address:

Background: Our aim was to evaluate the impact of comorbidities, clinical and biological factors on outcomes in elderly GBM patients treated with surgery followed by concurrent radiation (RT) and Temozolomide (TMZ).

Materials And Methods: Our sample includes 34 elderly patients with GBM who treated from January 2013 to December 2017. We collected data regarding age, extension of surgery, use of current medications, KPS, presenting symptoms, Prognostic Nutritional Index (PNI), Charlson Co-morbidity Index (CCI) and Frailty Index (FI). Read More

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http://dx.doi.org/10.1016/j.jgo.2019.03.009DOI Listing

Stress, Epigenetics and Depression: A Systematic Review.

Neurosci Biobehav Rev 2019 Apr 18. Epub 2019 Apr 18.

Mood Disorders Psychopharmacology Unit, University Health Network, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Department of Pharmacology, University of Toronto, Toronto, ON, Canada; Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Brain and Cognition Discovery Foundation, Toronto, ON, Canada.

Environmental stressors, such as childhood maltreatment, have been recognized to contribute to the development of depression. Growing evidence suggests that epigenetic changes are a key mechanism by which stressors interact with the genome leading to stable changes in DNA structure, gene expression, and behaviour. The current review aimed to evaluate the relationship between stress-associated epigenetic changes and depression. Read More

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http://dx.doi.org/10.1016/j.neubiorev.2019.04.010DOI Listing
April 2019
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Cause of Death in Utah Avalanche Fatalities, 2006-2007 through 2017-2018 Winter Seasons.

Wilderness Environ Med 2019 Apr 17. Epub 2019 Apr 17.

Utah Avalanche Center, Salt Lake City, UT.

Introduction: Understanding patterns of avalanche fatalities can aid prevention and rescue strategies. In 2007, we published a report reviewing avalanche deaths in Utah between the 1989-1990 and 2005-2006 winter seasons. In the current report, we discuss Utah avalanche fatalities from the 2006-2007 to 2017-2018 seasons. Read More

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http://dx.doi.org/10.1016/j.wem.2019.02.007DOI Listing

Adverse Childhood Experiences in Mothers with Chronic Pain and Intergenerational Impact on Children.

J Pain 2019 Apr 18. Epub 2019 Apr 18.

Department of Pediatrics, Institute on Development and Disability, Oregon Health & Science University.

Adverse childhood experiences (ACEs; e.g., parental divorce, physical or sexual abuse) are more prevalent in individuals with chronic pain compared to the general population. Read More

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http://dx.doi.org/10.1016/j.jpain.2019.04.004DOI Listing

Capnography: A support tool for the Detection of Return of Spontaneous Circulation in Out-of-Hospital Cardiac Arrest.

Resuscitation 2019 Apr 18. Epub 2019 Apr 18.

Department of Emergency Medicine.University of Texas SouthWestern Medical Center (UTSW).Dallas, United States.

Background: Automated detection of return of spontaneous circulation (ROSC) is still an unsolved problem during cardiac arrest. Current guidelines recommend the use of capnography, but most automatic methods are based on the analysis of the ECG and thoracic impedance (TI) signals. This study analysed the added value of EtCO for discriminating pulsed (PR) and pulseless (PEA) rhythms and its potential to detect ROSC. Read More

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http://dx.doi.org/10.1016/j.resuscitation.2019.03.048DOI Listing

Untangling the ethical intersection of epidemiology, human subjects research, and public health.

Ann Epidemiol 2019 Mar 27. Epub 2019 Mar 27.

Division of Epidemiology and Population Sciences, Department of Public Health Sciences, University of Miami, Miami, FL.

Purpose: Members of the American College of Epidemiology (ACE) Ethics Committee identified current ethics and epidemiology topic areas to consider for further discussion, consultation, teaching opportunities, and conference presentation. This article reflects on the activities of the Committee at the ACE Annual Meeting in New Orleans, Louisiana, September 24-26, 2017.

Methods: The overall aim for the Ethics Committee was to engage members of the College and other audiences and highlight the evolution of ethics and epidemiology since the inception of the original Ethics Guidelines published by the ACE Ethics and Standards of Practice Committee in 2000. Read More

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http://dx.doi.org/10.1016/j.annepidem.2019.03.009DOI Listing

Long-Term All-Cause and Cause-Specific Mortality in Asymptomatic Patients With CAC ≥1,000: Results From the CAC Consortium.

JACC Cardiovasc Imaging 2019 Mar 15. Epub 2019 Mar 15.

Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:

Objectives: This study thoroughly explored the demographic and imaging characteristics, as well as the all-cause and cause-specific mortality risks of patients with a coronary artery calcium (CAC) score ≥1,000 in the largest dataset of this population to date.

Background: CAC is commonly used to quantify cardiovascular risk. Current guidelines classify a CAC score of >300 or 400 as the highest risk group, yet little is known about the potentially unique imaging characteristics and mortality risk in individuals with a CAC score ≥1,000. Read More

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http://dx.doi.org/10.1016/j.jcmg.2019.02.005DOI Listing
March 2019
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Lightweight Lead Aprons: The Emperor's New Clothes in the Angiography Suite?

Eur J Vasc Endovasc Surg 2019 Apr 18. Epub 2019 Apr 18.

Department of Vascular and Endovascular Surgery, Royal Adelaide Hospital, Port Road, Adelaide, SA 5000, Australia; The University of Adelaide, SA, Australia.

Objective: The aim was to determine whether lead containing and lead free composite garments in current use provide the level of radiation protection stated by manufacturers.

Methods: Fifteen garments, produced by five different manufacturers using eight different composites, were randomly selected for testing from four hospitals in South Australia. Labelling, material composition, design, and condition of the garments were assessed by direct garment examination, garment label, and product information. Read More

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http://dx.doi.org/10.1016/j.ejvs.2019.01.031DOI Listing

Psychological and Psychosocial Interventions for Depression and Anxiety in Patients With Age-Related Macular Degeneration: A Systematic Review.

Am J Geriatr Psychiatry 2019 Mar 7. Epub 2019 Mar 7.

Centre of Psychology, Faculty of Psychology and Educational Sciences (NN, EC), University of Porto, Porto, Portugal.

Objective: To review the current literature on psychosocial and psychological interventions to prevent and treat depression and anxiety in patients with age-related macular degeneration (AMD).

Methods: The authors conducted a systematic review of literature evaluating psychosocial and psychological interventions for depression and anxiety in patients with AMD. Primary searches of PubMed, Cochrane library, EMBASE, Global Health, Web of Science, EBSCO, and Science Direct were conducted to include all articles published up to April 21, 2018. Read More

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http://dx.doi.org/10.1016/j.jagp.2019.03.001DOI Listing

PD-1/PD-L1 Combinations in Advanced Urothelial Cancer: Rationale and Current Clinical Trials.

Clin Genitourin Cancer 2019 Mar 29. Epub 2019 Mar 29.

New York University Perlmutter Cancer Center, New York, NY.

Chemotherapy is no longer the only viable option for patients with locally advanced or metastatic urothelial carcinoma. Immunotherapy, as checkpoint inhibition, has received United States Food and Drug Administration approval in the preceding several years, both in the second-line and first-line for cisplatin-ineligible patients. Those who respond often do so durably; however, response rates in the first line are 23% to 24%, and are lower in the second line. Read More

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http://dx.doi.org/10.1016/j.clgc.2019.03.009DOI Listing

Patterns of Youth Cigarette Experimentation and Onset of Habitual Smoking.

Am J Prev Med 2019 Apr 11. Epub 2019 Apr 11.

Department of Health Policy and Management, Yale School of Public Health, New Haven, Connecticut.

Introduction: Although research suggests that youth e-cigarette experimentation is associated with later combustible cigarette experimentation, it is unclear how this relates to habitual smoking. This study assesses how minors' patterns of combustible cigarette and e-cigarette experimentation relate to habitual smoking at ages 18-21 years.

Methods: Between November 2016 and May 2017, a cross-sectional, online survey of current and retrospective cigarette use was fielded among individuals aged 18-21 years who had tried combustible cigarettes or e-cigarettes (n=1,424). Read More

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http://dx.doi.org/10.1016/j.amepre.2019.02.009DOI Listing
April 2019
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